CN106668396A - Pharmaceutical composition for preventing and treating postpartum bodily pain and preparation method thereof - Google Patents

Pharmaceutical composition for preventing and treating postpartum bodily pain and preparation method thereof Download PDF

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CN106668396A
CN106668396A CN201611133196.7A CN201611133196A CN106668396A CN 106668396 A CN106668396 A CN 106668396A CN 201611133196 A CN201611133196 A CN 201611133196A CN 106668396 A CN106668396 A CN 106668396A
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herba
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating postpartum bodily pain and a preparation method thereof. The pharmaceutical composition is prepared from the following active pharmaceutical ingredients: common anotis herb, Hydrangea xanthoneura root, cucurbitacin C, fimbristylis and Lysimachia heterogenea. The pharmaceutical composition can be made into various preparation formulations by conventional preparation techniques, and has obvious curative effects on preventing and treating postpartum bodily pain.

Description

A kind of pharmaceutical composition of preventing and treating puerperal general pain and preparation method thereof
Technical field
The invention belongs to technical field of Chinese medicines, more particularly to a kind of pharmaceutical composition and its preparation side of preventing and treating puerperal general pain Method.
Background technology
Puerperal general pain, names of disease of tcm.Puerpera is referred within puerperal, limbs is occurred or joint is miserable, pain, numbness, weight The person of wearing, referred to as " puerperal general pain ".Also known as " pantalgia after delivery ", " arthralgia in puerperal ", " postpartum arthralgia ", " puerperal arthralgia ", custom Claim " puerperal exposure to wind ".The arthralgia that causes because of rheumatism, rheumatoid in western medicine puerperal, sciatica in puerperal, polymyositiss, There is similar symptom in postpartum thrombophlebitis, can mutually join with primary disease.If primary disease is treated in time, prognosis bona.But also there is portion Patient is divided to cause flaccidity syndrome and arthralgia syndrome disabled.Actually it is subordinate to motherland's medical science arthromyodynia category.Primary disease is mainly ferritic weakness, wound of just before giving birth losing blood Rule, hundred sections are hollow, passages through which vital energy circulates lose it is foster in moistening, in addition in puerperal health preserving accidentally, wind, cold, wet heresy is taken advantage of a weak point in opponent's defence in joint, meridians, flesh The natural fibre line of meat and cause, as《Shengji Zonglu》Cloud:" puerperal, QI and blood feared weak, and pathogen is easily attacked, and was hidden between the skin natural fibre line of meat, fought with positive gas phase, then make head Pain body aches ".《Medicine Comprehended》Say:" pantalgia after delivery, good to save the first transaction of a day's business by when producing hundred, blood vessels are hollow, flourish can not support ".It is comprehensive its Pathogenesis is nothing more than deficiency in origin and excess in superficiality, so paying attention to righting, giving consideration to both the incidental and fundamental, benefiting QI and nourishing blood, nourishing liver and kidney, warming the meridian and network in treatment.
Hydrangea xanthoncura Diels root：This product is Saxifragaceae silk ball platymiscium Huang arteries and veins silk ball Hydrangea xanthoneura The root of Diels.【Nature and flavor】It is pungent, temperature.【Indication】Blood circulation promoting and blood stasis dispelling, reunion of bone.Cure mainly fracture, rheumatic lumbago.【Character】 Root cylinder, distortion is about 8cm or longer, diameter about 2mm.Surface taupe, there is vertical wrinkle and radicula or root trace.Crust is easy Come off, the place that comes off is aobvious faint yellow.Matter is tough, and difficulty fractures, section yellow-white, fibroids.Feeble QI, acrid in the mouth.Record in dictionary of medicinal plant.
Herba Anotis ingratae：For Rubiaceae vacation plants of Hedyotis Herba Anotis ingratae Anotis ingrata (wall.) Hook. F. The herb of [Neanotis yngrata (Wall.ex Hook .f) W.H.Lewis].Summer, autumn receive adopt herb, eliminate soil, Debris, dry standby.【Nature and flavor】Acrid in the mouth；It is cool in nature.【Return through】The heart；Liver Channel.【Indication】Purging liver-fire.Main innominate toxic swelling；Mesh It is crimson swollen；Venom.【Former phytomorph】Renascent herb, up to 1m.Stem branch or does not have minority branch, it is upright or under The sleeping ground in portion.Leaf opposite；Petiole is short；The nearly triangle in stipule bottom, Colaesce is born between two petioles, edge tool fine hair；Blade , to ovum shape lanceolar, long 4-9cm, wide about 1.8cm, tip is tapering, base portion wedge shape, full edge for papery, oval or long oval, Two sides is by pubescence.Dichasium basidixed, total bennet and branch have narrow aliform corner angle；Floral white, without obstructing or have short Stalk；Calyx 4 splits, sliver triangular shape lanceolar, and corolla is about 5mm, and hat manages slightly wider, interior raw pubescence；Stamen 4, flower pesticide exposes corolla Outward；Ovary is the next, and Room 2, stigma 2 splits.Capsule is subsphaeroidal, slightly flat-sided, wide about 2mm.Seed is little and most, plano-convex, there is little wart point. The month at florescence 6-7, the fruiting period 7-8 month.Record in dictionary of medicinal plant.
Herba Fimbristylis dichotomae：For qi Herba Fimbristylis dichotomae Fimbristylis dichotoma (L) Vahl of Cyperaceae genus fimbristylis plant two [Scirpus dichotomus L.;S.annuus All.;Fimbristylis annua(All.)Roem.et Schult] Herb.Summer, autumn harvesting, clean, and dry.【Nature and flavor】It is lightly seasoned；It is cold in nature.【Return through】Kidney；Bladder warp.【Indication】Heat clearing away profit Urine；Removing toxic substances.Main dysuria；Damp and hot edema；Gonorrhea；Infantile carbuncle.【Chemical analysis】Containing dihydrocyperaquinone (dihydrooyperaqnone), tetrahydrocyperaquinone.(tetrahydrocyperaquinone), cyperaquinone (cyperapuinone), hydroxyl cyperaquinone (hydroxycyperapuinone), nor- cyperaquinone (demethylcyperapuinone).【Former phytomorph】Not tally Herba Fimbristylis dichotomae, draft.Stalk is grown thickly, high 20-50cm.Herb without Hair has thin pubescence.Leaf is linear, is shorter than stalk, and wide 1-2.5mm, tip is suddenly sharp or blunt；Sheath base portion keratin.Lobate bract under inflorescence 3-4, normal 1-2 pieces, is longer than inflorescence.Cyme is appeared again or simply；Small ear is avette or long round shape is avette, long 5-12mm, wide 2- 3mm, there is most flowers；Scale is avette or Long Circle, long 2-2.5mm, and sepia is glossy, there is 3-5 arteries and veins, and tip has short point；Stamen 2-3；Style is flat, and echinid is arranged at top；Stigma 2.Pyrene width obovate, biconvex shape, long 1-1.2mm, white to filbert, Surface is grown crosswise circular reticulate pattern, and longitudinal rib 7-9 bar, significant protuberance has brown short handle.Flower, the fruiting period 7-10 month.Record diction big in Chinese medicine Allusion quotation.
Black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis)：This product is the black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) Lysimachia heterogenea of Primulaceae Lysimachia plant Klatt. the herb of [L.paludicola Hemsl.].Summer, autumn harvesting, dry.【Nature and flavor】It is bitter；It is pungent；It is mild-natured.【Function master Control】Promoting blood circulation；Antidote against snake bite.Main amenorrhea；Venom.【Former phytomorph】Perennial herb.Stem is upright, high 40-80cm, Herb Without hair.Four prismatics, seamed edge has narrow wing and black gland point, and middle part above multi-branched, branch pole is carried out.Basal leaf piece cochlear, long 1- 6cm, wide 0.6-3.8cm, tip circle is blunt, and base portion is downward into wing handle, and flower does not exist often；Stem leaf opposite, stockless；Blade drapes over one's shoulders pin Shape or wire lanceolar, few long round shape lanceolar, long 4-13cm, wide 1-3cm, tip is slightly sharp sharp or blunt, and base portion is blunt or ear Half armful of stem, the granular gland point of the close raw black in two sides.Raceme is born in stem end and branch end, long 8-13cm；Bract is lobate, lanceolar, Upwards gradual change is little, is longer than or near etc. is longer than bennet；The long 3-5mm of bennet；The long 4-5mm of calyx, 5 divisions closely reach base portion, sliver wire Lanceolar, tip is tapering and crimps to back：Corolla white, is about 7mm, and base portion symphysis part is about 2.5mm, 5 divisions, sliver Ovate Long Circle；Vertebra stamen 5, the middle part of filigree adhesion to corolla closely isometric with corolla, separate section is about 3mm, flower pesticide gland shape, It is about 1.5mm, connective tip tool calluss shape tip；Ovary is upper without hair, and Room 1, style is about 6mm, and stigma expands.Capsule ball Shape, diameter about 3mm.The black purple of seed.The month at florescence 5-7, the fruiting period 8-10 month.Record in dictionary of medicinal plant.
Cucurbitacin C（Cucurbitacin C）：CAS 5988-76-1, molecular formula C32H48O8, molecular weight 560.73.【Into Divide source】Fructus Cucumidis sativi Cucumis sativus, bitter Fructus Cucumidis sativi Cucumis sativus var.hanzil.
Cucurbitacin C（Cucurbitacin C）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition of effective preventing and treating puerperal general pain And preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for making the crude drug of the pharmaceutical composition of the preventing and treating puerperal general pain be：
Herba Anotis ingratae 480-490 weight portion Hydrangea xanthoncura Diels root 450-460 weight portion cucurbitacin C5-7 weight portion Herba Fimbristylis dichotomae 380- The black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 346-348 weight portions of 390 weight portions.
The pharmaceutical composition of preventing and treating puerperal general pain is preferably used in, is made up of the crude drug of following weight portion：
The black gland of the weight portion of 485 weight portion Hydrangea xanthoncura Diels root of Herba Anotis ingratae, 455 weight portion cucurbitacin C6 weight portions Herba Fimbristylis dichotomae 385 is precious The weight portion of pearl dish 347.
A kind of pharmaceutical composition of preventing and treating puerperal general pain, it is characterised in that pharmaceutical composition can adopt the routine of galenic pharmacy Method prepares piece agent or capsule or drop pill.
A kind of pharmaceutical composition of preventing and treating puerperal general pain, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine Preventing and treating puerperal general pain medicine.
A kind of preparation method of the pharmaceutical composition of preventing and treating puerperal general pain, it is characterised in that prepare as follows：
The composition and weight portion of crude drug be：Herba Anotis ingratae 480-490 weight portion Hydrangea xanthoncura Diels root 450-460 weight portion cucurbitacins The black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 346-348 weight portions of C5-7 weight portion Herba Fimbristylis dichotomae 380-390 weight portions；
Preparation method：
（1）Herba Anotis ingratae, Hydrangea xanthoncura Diels root, cucurbitacin C, Herba Fimbristylis dichotomae, black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) are taken by crude drug proportioning, is mixed, use weight The ethanol of percent concentration 36% is extracted as solvent in 32 DEG C of warm macerating, and extraction time is 15 times, and each extraction time is 15 hours, Every time solvent load is 36 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.07, filtration, medicinal liquid is first washed with water by HZ-801 macroporous adsorptive resins, then uses weight percent concentration 22% ethanol solution eluting HZ-801 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, Concentrate drying, obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 42% as solvent, heating and refluxing extraction 22 times, carries every time The time is taken for 0.1 hour, each solvent load is 10 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.03 is concentrated into, is filtered, medicinal liquid is first washed with water by DM-7HP macroporous adsorptive resins, then with again The amount ethanol solution eluting DM-7HP macroporous adsorptive resins of percent concentration 59%, collect the ethanol elution of weight percent concentration 59% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
The preparation method of the pharmaceutical composition of preferred a kind of preventing and treating puerperal general pain, it is characterised in that make as follows It is standby：
The composition and weight portion of crude drug be：The weight portion cucurbitacin C6 weight portions of 485 weight portion Hydrangea xanthoncura Diels root of Herba Anotis ingratae 455 The black weight portion of gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 347 of the weight portion of Herba Fimbristylis dichotomae 385；
Preparation method：
（1）Herba Anotis ingratae, Hydrangea xanthoncura Diels root, cucurbitacin C, Herba Fimbristylis dichotomae, black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) are taken by crude drug proportioning, is mixed, use weight The ethanol of percent concentration 36% is extracted as solvent in 32 DEG C of warm macerating, and extraction time is 15 times, and each extraction time is 15 hours, Every time solvent load is 36 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.07, filtration, medicinal liquid is first washed with water by HZ-801 macroporous adsorptive resins, then uses weight percent concentration 22% ethanol solution eluting HZ-801 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, Concentrate drying, obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 42% as solvent, heating and refluxing extraction 22 times, carries every time The time is taken for 0.1 hour, each solvent load is 10 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.03 is concentrated into, is filtered, medicinal liquid is first washed with water by DM-7HP macroporous adsorptive resins, then with again The amount ethanol solution eluting DM-7HP macroporous adsorptive resins of percent concentration 59%, collect the ethanol elution of weight percent concentration 59% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition of preventing and treating puerperal general pain, it is characterised in that pharmaceutical composition can be using system The conventional method of agent prepares piece agent or capsule or drop pill.
A kind of preparation method of the pharmaceutical composition of preventing and treating puerperal general pain, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine composition preventing and treating puerperal general pain medicine.
Pharmaceutical composition preventing and treating puerperal general pain is evident in efficacy.
Specific embodiment
Embodiment 1：Pharmaceutical composition of preventing and treating puerperal general pain and preparation method thereof
Preventing and treating puerperal general pain pharmaceutical composition crude drug composition and weight portion be：Herba Anotis ingratae 485g Hydrangea xanthoncura Diels roots The black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 347g of 455g cucurbitacin C6g Herba Fimbristylis dichotomae 385g；
Preparation method：
（1）Herba Anotis ingratae, Hydrangea xanthoncura Diels root, cucurbitacin C, Herba Fimbristylis dichotomae, black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) are taken by crude drug proportioning, is mixed, use weight The ethanol of percent concentration 36% is extracted as solvent in 32 DEG C of warm macerating, and extraction time is 15 times, and each extraction time is 15 hours, Every time solvent load is 36 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.07, filtration, medicinal liquid is first washed with water by HZ-801 macroporous adsorptive resins, then uses weight percent concentration 22% ethanol solution eluting HZ-801 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, Concentrate drying, obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 42% as solvent, heating and refluxing extraction 22 times, carries every time The time is taken for 0.1 hour, each solvent load is 10 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.03 is concentrated into, is filtered, medicinal liquid is first washed with water by DM-7HP macroporous adsorptive resins, then with again The amount ethanol solution eluting DM-7HP macroporous adsorptive resins of percent concentration 59%, collect the ethanol elution of weight percent concentration 59% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Pharmaceutical composition of preventing and treating puerperal general pain and preparation method thereof
Preventing and treating puerperal general pain pharmaceutical composition crude drug composition and weight portion be：Herba Anotis ingratae 480g Hydrangea xanthoncura Diels roots The black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 346g of 460g cucurbitacin C5g Herba Fimbristylis dichotomae 390g；
Preparation method：
（1）Herba Anotis ingratae, Hydrangea xanthoncura Diels root, cucurbitacin C, Herba Fimbristylis dichotomae, black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) are taken by crude drug proportioning, is mixed, use weight The ethanol of percent concentration 36% is extracted as solvent in 32 DEG C of warm macerating, and extraction time is 15 times, and each extraction time is 15 hours, Every time solvent load is 36 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.07, filtration, medicinal liquid is first washed with water by HZ-801 macroporous adsorptive resins, then uses weight percent concentration 22% ethanol solution eluting HZ-801 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, Concentrate drying, obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 42% as solvent, heating and refluxing extraction 22 times, carries every time The time is taken for 0.1 hour, each solvent load is 10 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.03 is concentrated into, is filtered, medicinal liquid is first washed with water by DM-7HP macroporous adsorptive resins, then with again The amount ethanol solution eluting DM-7HP macroporous adsorptive resins of percent concentration 59%, collect the ethanol elution of weight percent concentration 59% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Pharmaceutical composition of preventing and treating puerperal general pain and preparation method thereof
Preventing and treating puerperal general pain pharmaceutical composition crude drug composition and weight portion be：Herba Anotis ingratae 490g Hydrangea xanthoncura Diels roots The black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 348g of 450g cucurbitacin C7g Herba Fimbristylis dichotomae 380g；
Preparation method：
（1）Herba Anotis ingratae, Hydrangea xanthoncura Diels root, cucurbitacin C, Herba Fimbristylis dichotomae, black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) are taken by crude drug proportioning, is mixed, use weight The ethanol of percent concentration 36% is extracted as solvent in 32 DEG C of warm macerating, and extraction time is 15 times, and each extraction time is 15 hours, Every time solvent load is 36 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.07, filtration, medicinal liquid is first washed with water by HZ-801 macroporous adsorptive resins, then uses weight percent concentration 22% ethanol solution eluting HZ-801 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, Concentrate drying, obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 42% as solvent, heating and refluxing extraction 22 times, carries every time The time is taken for 0.1 hour, each solvent load is 10 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.03 is concentrated into, is filtered, medicinal liquid is first washed with water by DM-7HP macroporous adsorptive resins, then with again The amount ethanol solution eluting DM-7HP macroporous adsorptive resins of percent concentration 59%, collect the ethanol elution of weight percent concentration 59% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 73g of Example 1, adds starch 143g, mixes, and granulation is dried, plus Microcrystalline Cellulose 34g, stearic acid Magnesium 3g, mixes, and is pressed into 600, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 237g of Example 2, adds starch 143g, mixes, and granulation is dried, granulate, adds appropriate stearic acid Magnesium, mixes, and encapsulated 1200, obtains final product medicament composition capsule.
Embodiment 6：The preparation of drop pill
Weigh (80 DEG C) heating of polyethylene glycol 6000 310g water-baths and boil molten, add the pharmaceutical composition 15g of embodiment 3, fully stir Mix uniform, with liquid paraffin as coolant, put glass tubing（4*80cm）In, chilling temperature is -3 DEG C, and drip internal-and external diameter is 7.0/ 2.0 (mm/mm), drip is 2.4cm away from liquid level, and drop speed, as optimum condition, with cotton the cold of drop pill surface is blotted with per point 59 drops Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：The pharmaceutical composition of preventing and treating puerperal general pain
Preventing and treating puerperal general pain pharmaceutical composition crude drug composition and weight portion be：
The black weight portion of gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 300 of the weight portion of 489 weight portion Herba Fimbristylis dichotomae of Herba Anotis ingratae 350.
Embodiment 8：The pharmaceutical composition of preventing and treating puerperal general pain
Preventing and treating puerperal general pain pharmaceutical composition crude drug composition and weight portion be：
The black weight portion of gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 200 of the weight portion of cucurbitacin C1 weight portions Herba Fimbristylis dichotomae 190.
Embodiment 9：The pharmaceutical composition of preventing and treating puerperal general pain
Preventing and treating puerperal general pain pharmaceutical composition crude drug composition and weight portion be：
The black weight portion of gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 140 of the weight portion of cucurbitacin C4 weight portions Herba Fimbristylis dichotomae 300.
Experimental example 1：The experimental study of preventing and treating puerperal general pain
1 clinical data
1.1 case selection
This group 36, is outpatient, and the age is minimum 20 years old, maximum 40 years old, 31.5 years old mean age, wherein 20-30 year 24 Example, 31-40 year 12.The course of disease is most short 2 months, most long 2.5 years, average 5.5 months, 14 within 3 months, -1 year 4 months 12 Example, more than 1 year 10.
1.2 clinical manifestation
All cases have different degrees of limbs joint pain, miserable, numbness and uncomfortableness, and pale complexion, expression pain, pain is difficult Bear.Wherein migratory pain, the indefinite person of migration 6, pain as being stabbed, localized pain person；Waist-leg patient 6, with dizzy headache Person 5, prolonged lochiorrhea person 4；Leukorrhagia white or many persons of yellow skin amount 3, hypogastric region cold type of pain person 2, lab testing resists " O " (+) person 2, rheumatoid factor positive person 1, erythrocyte sedimentation rate rising person 2.
2 Therapeutic Method
Give self-control pharmaceutical composition（The pharmaceutical composition lot number 20110825 of embodiment 1）Treatment, plus-minus:If prolonged lochiorrhea person drinks Plus Crinis Carbonisatus, Platycladi Cacumen carbonisatum；Hypogastric region cold type of pain person drinks plus Fructus Foeniculi, Fructus Evodiae；Profuse leukorrhea person is drunk with Semen Euryaless, Os Sepiae；Head Dizzy headache person adds Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii；Waist-leg patient drinks to add and processs Radix Aconiti, Radix Aconiti Kusnezoffii Preparata, daily 1 dose（Every dose of pharmaceutical composition 2.5g）, The sub-service of decocting morning and evening, serve on 10 days for 1 course for the treatment of.
3 criterions of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Cure:Clinical symptom disappearance, sign and every inspections recover normal；It is effective:Symptom, sign and every inspection are obvious Improve；Do not heal:The state of an illness is unchanged after treatment.
3.2 therapeutic outcome
1-2 course for the treatment of of this group of case medication 21, the 3-4 course for the treatment of 15, wherein curing 28, takes a turn for the better 6, not more 2, always has Efficiency is 94.44%, and treatment time is most short 10 days, and most long nearly 40 days, the short person's curative effect of the course of disease is good.
4 model cases
Ma, female, 27 years old, in the first visit of October 12 in 2012.Patient catches a cold for 15 days before and after half a year, general joint pain occurs Bitterly, miserable numb, joint stuffiness, gradually increases, and Jing takes Chinese medicine and western medicine, acupuncture and naturopathy, does not improve, symptoms include limb all over Body pain, lumbago increases, it is difficult to stand as rolled on Changes in weather general joint pain, with dizziness headache, leukorrhagia polychrome it is white and It is dilute.Check:Pale complexion, look pain, extremity and waist have no abnormal changes, and joint motion is still normal, and joint is without substantially swollen Swollen, skin temperature is also normal, lab testing:ESR28mm/m, RF (-), ASO (-), pulse condition carefully delays, corpulent tongue tongue is white, and card category is new to be produced Deficiency of qi and blood afterwards, hundred sections are hollow, and passages through which vital energy circulates loses foster in moistening, and feels exopathogen again in addition, and it is stagnant and obstructed to keep meridians, joint, muscle, control with Blood yiqi, promoting the flow of QI in the collateral by warming the meridian, side is selected from pharmacy compositions（The pharmaceutical composition lot number 20110825 of embodiment 1）Treatment plus taste, Daily 1 dose（Every dose of pharmaceutical composition 2.5g）, the sub-service of decocting morning and evening serve on 7 doses, and dizziness headache is healed, and lumbago and skelalgia is clearly better, Leukorrhagia is reduced, and 10 doses of following the service is had rosy cheeks, and all illness disappear, and extremities joint activity freely, checks erythrocyte sedimentation rate, anti-O, rheumatoid factor Normal, follow-up 1 year is not recurred again.

Claims (8)

1. it is a kind of preventing and treating puerperal general pain pharmaceutical composition, it is characterised in that make the pharmaceutical composition crude drug composition and Weight portion is：
Herba Anotis ingratae 480-490 weight portion Hydrangea xanthoncura Diels root 450-460 weight portion cucurbitacin C5-7 weight portion Herba Fimbristylis dichotomae 380- The black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 346-348 weight portions of 390 weight portions.
2. according to claim 1 it is a kind of preventing and treating puerperal general pain pharmaceutical composition, it is characterised in that make the drug regimen The composition and weight portion of the crude drug of thing be：
The black gland of the weight portion of 485 weight portion Hydrangea xanthoncura Diels root of Herba Anotis ingratae, 455 weight portion cucurbitacin C6 weight portions Herba Fimbristylis dichotomae 385 is precious The weight portion of pearl dish 347.
3. a kind of pharmaceutical composition of preventing and treating puerperal general pain according to claim 1, it is characterised in that pharmaceutical composition can be with Piece agent or capsule or drop pill are prepared using the conventional method of galenic pharmacy.
4. according to claim 1 it is a kind of preventing and treating puerperal general pain pharmaceutical composition, it is characterised in that pharmaceutical composition with change Learn the preventing and treating puerperal general pain medicine of medicine or Chinese medicine composition.
5. it is a kind of preventing and treating puerperal general pain pharmaceutical composition preparation method, it is characterised in that prepare as follows：
The composition and weight portion of crude drug be：Herba Anotis ingratae 480-490 weight portion Hydrangea xanthoncura Diels root 450-460 weight portion cucurbitacins The black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 346-348 weight portions of C5-7 weight portion Herba Fimbristylis dichotomae 380-390 weight portions；
Preparation method：
（1）Herba Anotis ingratae, Hydrangea xanthoncura Diels root, cucurbitacin C, Herba Fimbristylis dichotomae, black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) are taken by crude drug proportioning, is mixed, use weight The ethanol of percent concentration 36% is extracted as solvent in 32 DEG C of warm macerating, and extraction time is 15 times, and each extraction time is 15 hours, Every time solvent load is 36 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.07, filtration, medicinal liquid is first washed with water by HZ-801 macroporous adsorptive resins, then uses weight percent concentration 22% ethanol solution eluting HZ-801 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, Concentrate drying, obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 42% as solvent, heating and refluxing extraction 22 times, carries every time The time is taken for 0.1 hour, each solvent load is 10 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.03 is concentrated into, is filtered, medicinal liquid is first washed with water by DM-7HP macroporous adsorptive resins, then with again The amount ethanol solution eluting DM-7HP macroporous adsorptive resins of percent concentration 59%, collect the ethanol elution of weight percent concentration 59% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. according to claim 5 it is a kind of preventing and treating puerperal general pain pharmaceutical composition preparation method, it is characterised in that by such as It is prepared by lower step：
The composition and weight portion of crude drug be：The weight portion cucurbitacin C6 weight portions of 485 weight portion Hydrangea xanthoncura Diels root of Herba Anotis ingratae 455 The black weight portion of gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 347 of the weight portion of Herba Fimbristylis dichotomae 385；
Preparation method：
（1）Herba Anotis ingratae, Hydrangea xanthoncura Diels root, cucurbitacin C, Herba Fimbristylis dichotomae, black gland Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) are taken by crude drug proportioning, is mixed, use weight The ethanol of percent concentration 36% is extracted as solvent in 32 DEG C of warm macerating, and extraction time is 15 times, and each extraction time is 15 hours, Every time solvent load is 36 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.07, filtration, medicinal liquid is first washed with water by HZ-801 macroporous adsorptive resins, then uses weight percent concentration 22% ethanol solution eluting HZ-801 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, Concentrate drying, obtains final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 42% as solvent, heating and refluxing extraction 22 times, carries every time The time is taken for 0.1 hour, each solvent load is 10 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.03 is concentrated into, is filtered, medicinal liquid is first washed with water by DM-7HP macroporous adsorptive resins, then with again The amount ethanol solution eluting DM-7HP macroporous adsorptive resins of percent concentration 59%, collect the ethanol elution of weight percent concentration 59% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. according to claim 5 it is a kind of preventing and treating puerperal general pain pharmaceutical composition preparation method, it is characterised in that medicine Compositionss can adopt the conventional method of galenic pharmacy to prepare piece agent or capsule or drop pill.
8. according to claim 5 it is a kind of preventing and treating puerperal general pain pharmaceutical composition preparation method, it is characterised in that medicine Compositionss and chemical drugs or Chinese medicine composition preventing and treating puerperal general pain medicine.
CN201611133196.7A 2016-12-10 2016-12-10 Pharmaceutical composition for preventing and treating postpartum bodily pain and preparation method thereof Withdrawn CN106668396A (en)

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Application publication date: 20170517