CN106728624A - A kind of pharmaceutical composition for preventing and treating viral pharyngitis and preparation method thereof - Google Patents
A kind of pharmaceutical composition for preventing and treating viral pharyngitis and preparation method thereof Download PDFInfo
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- CN106728624A CN106728624A CN201611133089.4A CN201611133089A CN106728624A CN 106728624 A CN106728624 A CN 106728624A CN 201611133089 A CN201611133089 A CN 201611133089A CN 106728624 A CN106728624 A CN 106728624A
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- 230000002607 hemopoietic effect Effects 0.000 description 1
- CBZFLMNNXKRPHN-UHFFFAOYSA-N hopene-a Natural products C12CCC3C4(C)CCCC(C)(C)C4CCC3(C)C1(C)CCC1C2(C)CCC1=C(C)C CBZFLMNNXKRPHN-UHFFFAOYSA-N 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- -1 hydroxyl cyperaquinone Chemical compound 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000004441 taeniasis Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
- KYBLAIAGFNCVHL-PMVHANJISA-N zeorin Chemical compound C([C@]1(C)[C@H]2CC[C@H]34)CCC(C)(C)[C@@H]1[C@@H](O)C[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@@H]1C(C)(O)C KYBLAIAGFNCVHL-PMVHANJISA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
- A61K36/8895—Calamus, e.g. rattan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/10—Bryophyta (mosses)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
The invention discloses a kind of pharmaceutical composition for preventing and treating viral pharyngitis and preparation method thereof, pharmaceutical composition of the present invention is with Doryopteris concolor (Langsd et Fisch.) Kuhn, bladdernut, saikosaponin C, 10000 years moss, dichotomous fimbristylis herbs as bulk drug, proportioning is formed, routinely various formulations can be made by preparation process, preventing and treating viral pharyngitis is evident in efficacy.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for preventing and treating viral pharyngitis and its preparation
Method.
Background technology
Viral infection there is no specific drugs at present.Acute viral pharyngitis is clinically common disease, frequently-occurring disease, in belonging to
The category of medical science " larynx numbness ".More because wind-heat exopathogen is attacked in throat, perverse trend text bridle, and it is not smooth to cause blood to run, the raw hemostasis of change.In
Medical science " having all diseases of throat to come under fire " is said.《Danxi's experiential therapy》:Larynx numbness is mostly hot phlegm, and heat evil is followed through throat of burning, and makes pharynx
Larynx swells and ache, and the pharyngalgia that arrives.Antiviral, anti-infectives, but viral multi-Vari being used western medical treatment, treatment there is no special side more
Method, and curative effect appearance is later, antiviral, anti-infectives have certain side effect to some patientss, and pain is injected in addition, are difficult
It is accepted by patients.Chinese medicine is antiviral to be different from Western medicine, and he is not directed to certain several virus, but work is killed in the suppression for having wide spectrum to virus
With.Hit the interpretation of the cause, onset and process of an illness, satisfactory effect.
Bladdernut：This product is Palmae herba fibraureae recisae platymiscium herba fibraureae recisae Daemonorops margaritae（Hance）Becc.
[Calamus margaritae Hance ］ stem.Whole year can be adopted, and segment is dried.【Nature and flavor】Bitter；It is mild-natured.【Function master
Control】Expelling parasite；It is treating stranguria；Wind dispelling is relieved pain.Main roundworm；Pinworm；Taeniasis；Urine leaching pain；Dentalgia.【Former phytomorph】Herba fibraureae recisae, spinosity
Big liana.Stem is upright at the beginning, after climb up by holding on to shape.Leaf pinniform is totally cleaved, total length 2-3m, and rachis top extends into the fine whip of tool claw-like thorn；
The nearly opposite of sliver, 50-75 pairs, strip lanceolar, 25-45cm long, l-2cm wide, tip is tapering, and the rachis back side differs in size down
Curved or rigidness thorn；Leaf sheath is without fine whip but has flat thorn.Spadix bloom before for spathe encloses, in spindle, 25- long
30cm, Zhu Duan shape of tail are tapering, and the close straight thrust by brown, flat in 1 piece of outside, the spathe of the inside is pierced or stingless less, is yielded positive results
Spathe comes off afterwards.Rachilla on male inflorescence is intensive, is about 3cm, spends intensive, and male flower round shape long is avette, 5mm long；Calyx cup
Shape, shallow 3 tooth；Corolla 3 splits, and about 2 times are longer than calyx；Stamen 6, is about 3.5mm, involucre tazza shape.Female flower：Calyx short cylinder shaped, first
Hold 3 fissures；Petal lanceolar, be about calyx 2 times long；Ovary is avette, 3 pieces of column cap.Fruit is spherical, diameter 1.8-2cm, has
The scale of 18-20 row files, scale has a 10-20, yellow and bright on every 1 row, there is groove.The seed kidney shape is spherical.Florescence 5
Month, the fruiting period 6-10 months.Record in dictionary of medicinal plant.
Doryopteris concolor (Langsd et Fisch.) Kuhn：This product is Sinopteridaceae Doryopteris concolor (Langsd et Fisch.) Kuhn platymiscium Doryopteris concolor (Langsd et Fisch.) Kuhn Doryopteris concolor（Langsd.
Et Fisch.）The herb of Kuhn [Pteris concolor Langsd. Et Fisch.].Summer, autumn harvesting, clean, and shine
It is dry.【Nature and flavor】Slight bitter；It is puckery；It is cool.【Return through】Enter bladder, the warp of liver two.【Indication】Reducing fever and causing diuresis；Hemostasis.Main stranguria；Wound goes out
Blood.【Chemical analysis】Leaf contains 22（29）- hopenen [hop-22（29）- ene], hopanol（hydroxyhopane）, 6,22- what
Handkerchief glycol（zeorin）, freidelin（friedelin）, fern -9（11）- alkene [fern-9（11）- ene], squalene
（squalene）.【Former phytomorph】Terrestrial pteridophyte, plant 20-35cm high.Rhizome is short and tiny, near upright, is draped over one's shoulders pin
There is 1 chestnut black middle rib of thickness in shape scale, light brown, center.Leaf papery, fasciation, a type；Petiole, rachis and pinna rachis are bright
Atropurpureus, petiole 6-24cm long is dredged by brown undercoat, and rear dipped beam is slided, and base portion is by scale；The nearly pentagon of blade, length and width are closely equal,
4-8cm, acumen, the wealthy heart-shaped or halberd shape of base portion, several to be split for third, central 1 wealthy rhombus, pinniform drastic crack, 3.5-5cm long is wide
2-4cm, base portion wealthy wedge shape is downward in rachis, and base portion 1 is maximum to pinnule, pinniform partly split or it is shallow split, side life accessory pinna triangle,
3-4.5cm long, 2.5-3.5cm wide, the downward wealthy wing downward with central 1 of base portion are connected, lower base pinnule speciality, pinniform
Drastic crack, the 2nd pinnule has bastard, and remaining full edge, upside pinnule is short, full edge；Vein pinniform, scun dichotomy.Spore
Sorus is distributed along sliver both sides of the edge, tip and incises infertility；Indusium full edge.Record in dictionary of medicinal plant.
10000 years moss：This product is ten thousand Nian Xian sections, 10000 years Rhodobryum plants, 10000 years moss Climacium dendroides（Hedw.）
The plant of Web.et Mohr ［ Leskea dendroides Hedw. ］.Spring, summer harvesting, clean, and dry.【Nature and flavor】It is bitter；
It is cold.【Indication】Removing damp-heat；Stimulate the circulation of the blood and cause the muscles and joints to relax.Main rheumatism internal lesion caused by overexertion；Arthralgia and myalgia.【Chemical analysis】Containing cupreol (β-
Sitosterol), stigmasterol (stigmasterol), ergosterol (ergosterol), campesterol (campesterol),
Cyclolaudenol (cyclolaudenol), 31- removes first cyclolaudenol (31-norcyclolaudenol), and metal
Elemental iron, manganese, zinc, copper etc..【Former phytomorph】Plant is thick in tree-like, and subterranean stem crawls to grow wild, and has rhizoid and film quality squama
Shape leaflet.The aerial stem of plant is upright, multi-branched, up to 15-20cm, the densely covered green palea of branch.The leaf on stem top and branched base part
Blade is in ovate triangle wide or ovum shape lanceolar, and base portion is slightly downward.Middle rib is single, and up in termination before blade tip, blade top is thin
The narrow rhombus of born of the same parents, leaf corner cell is circular, semi-transparent clear.The blade on branch top is smaller, long and narrow lanceolar, leaf edge sawtooth reach in
Middle part.Dioecism.Seta is elongated, 2-4cm long, red；Sporangium is upright, and cylindricality long has more；The female shape of opercule circle high；Capsule balaclava
Shape, the full sporangium of clad.Record in dictionary of medicinal plant.
Dichotomous fimbristylis herb：It is Cyperaceae genus fimbristylis plant two qi dichotomous fimbristylis herb Fimbristylis dichotoma (L) Vahl
[Scirpus dichotomus L.;S.annuus All.;Fimbristylis annua(All.)Roem.et Schult]
Herb.Summer, autumn harvesting, clean, and dry.【Nature and flavor】It is lightly seasoned；It is cold in nature.【Return through】Kidney；Bladder warp.【Indication】Heat-clearing profit
Urine；Removing toxic substances.Main difficult urination；Damp and hot edema；Gonorrhoea；Infant fetal toxin.【Chemical analysis】Containing dihydrocyperaquinone
(dihydrooyperaqnone), tetrahydrocyperaquinone.(tetrahydrocyperaquinone), cyperaquinone
(cyperapuinone), hydroxyl cyperaquinone (hydroxycyperapuinone), removes first cyperaquinone
(demethylcyperapuinone).【Former phytomorph】Not tally dichotomous fimbristylis herb, draft.Stalk is grown thickly, 20-50cm high.Complete stool without
Hair has thin pubescence.Leaf is linear, is shorter than stalk, and 1-2.5mm wide, tip is suddenly sharp or blunt；Sheath base portion keratin.Lobate bract under inflorescence
3-4, normal 1-2 pieces, is longer than inflorescence.Cyme is appeared again or simply；Small ear is avette or round shape long is avette, 5-12mm long, 2- wide
3mm, there is most flowers；Scale is avette or Long Circle, 2-2.5mm long, and sepia is glossy, there is 3-5 arteries and veins, and tip has short point；Stamen
2-3；Style is flat, and echinid is arranged at top；Column cap 2.Pyrene obovate wide, biconvex shape, 1-1.2mm long, white to filbert,
Surface is grown crosswise circular reticulate pattern, and longitudinal rib 7-9 bars, significant protuberance has brown short handle.Flower, the fruiting period 7-10 months.Record in the big diction of Chinese medicine
Allusion quotation.
Saikosaponin C（ Saikosaponin C）：CAS 20736-08-7, molecular formula C48H78O17, molecular weight
927.12.【Ingredient origin】Radix bupleuri Bupleurum chinense, RADIX BUPLEURI SCORZONERIFOLII Bupleurum scorzonerifolium.
1 bulk drug chemical constitution：
Saikosaponin C（ Saikosaponin C）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of drug regimen of effective preventing and treating viral pharyngitis
Thing and preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition of the preventing and treating viral pharyngitis be：
Doryopteris concolor (Langsd et Fisch.) Kuhn 86-88 weight portion bladdernut 60-64 weight portion saikosaponin C 1-1.2 10000 years moss 50-52 weight of weight portion
Part dichotomous fimbristylis herb 30-36 weight portions.
The pharmaceutical composition of preventing and treating viral pharyngitis is preferably used in, is made up of the bulk drug of following weight portion：
87 weight portion bladdernut of Doryopteris concolor (Langsd et Fisch.) Kuhn, 62 weight portion saikosaponin C, 1.1 weight portion, 10000 years weight portion dichotomous fimbristylis herbs 33 of moss 51
Weight portion.
A kind of pharmaceutical composition for preventing and treating viral pharyngitis, it is characterised in that pharmaceutical composition can be using the normal of galenic pharmacy
Rule method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for preventing and treating viral pharyngitis, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine
Preventing and treating viral pharyngitis medicine.
A kind of preparation method of the pharmaceutical composition for preventing and treating viral pharyngitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Doryopteris concolor (Langsd et Fisch.) Kuhn 86-88 weight portion bladdernut 60-64 weight portion saikosaponin Cs 1-1.2
10000 years moss 50-52 weight portion dichotomous fimbristylis herb 30-36 weight portions of weight portion；
Preparation method：
（1）Doryopteris concolor (Langsd et Fisch.) Kuhn, bladdernut, saikosaponin C, 10000 years moss, dichotomous fimbristylis herbs are taken by bulk drug proportioning, is mixed, use percentage by weight
The ethanol of concentration 32% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 59 hours, molten every time
Agent consumption is 70 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close
Degree 1.02, filtration, liquid is first washed with water by SP825 large pore resin absorption columns, then with the ethanol of weight percent concentration 16%
Eluant solution SP825 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 16%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 46% as solvent, heating and refluxing extraction 24 times is carried every time
The time is taken for 0.3 hour, each solvent load is 30 times of dregs of a decoction A weight, filtration obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed
Ethanol, is concentrated into relative density 1.06, and filtration, liquid is first washed with water, then use weight by DM-7HP large pore resin absorption columns
The ethanol solution of percent concentration 63% elutes DM-7HP large pore resin absorption columns, collects the ethanol elution of weight percent concentration 63%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
The preparation method of preferred a kind of pharmaceutical composition for preventing and treating viral pharyngitis, it is characterised in that make as follows
It is standby：
The composition and weight portion of bulk drug be：The weight portion of 87 weight portion bladdernut of Doryopteris concolor (Langsd et Fisch.) Kuhn, 62 weight portion saikosaponin C 1.1
10000 years weight portions of 51 weight portion dichotomous fimbristylis herb of moss 33；
Preparation method：
（1）Doryopteris concolor (Langsd et Fisch.) Kuhn, bladdernut, saikosaponin C, 10000 years moss, dichotomous fimbristylis herbs are taken by bulk drug proportioning, is mixed, use percentage by weight
The ethanol of concentration 32% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 59 hours, molten every time
Agent consumption is 70 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close
Degree 1.02, filtration, liquid is first washed with water by SP825 large pore resin absorption columns, then with the ethanol of weight percent concentration 16%
Eluant solution SP825 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 16%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 46% as solvent, heating and refluxing extraction 24 times is carried every time
The time is taken for 0.3 hour, each solvent load is 30 times of dregs of a decoction A weight, filtration obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed
Ethanol, is concentrated into relative density 1.06, and filtration, liquid is first washed with water, then use weight by DM-7HP large pore resin absorption columns
The ethanol solution of percent concentration 63% elutes DM-7HP large pore resin absorption columns, collects the ethanol elution of weight percent concentration 63%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for preventing and treating viral pharyngitis, it is characterised in that pharmaceutical composition can be used
The conventional method of galenic pharmacy prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for preventing and treating viral pharyngitis, it is characterised in that pharmaceutical composition and chemical drugs
Or Chinese medicine composition preventing and treating viral pharyngitis medicine.
Pharmaceutical composition preventing and treating viral pharyngitis is evident in efficacy.
Specific embodiment
Embodiment 1：Prevent and treat pharmaceutical composition of viral pharyngitis and preparation method thereof
Prevent and treat viral pharyngitis pharmaceutical composition bulk drug composition and weight portion be：Doryopteris concolor (Langsd et Fisch.) Kuhn 87g bladdernut 62g bavins
10000 years moss 51g dichotomous fimbristylis herbs 33g of Hu saponin(e C1.1g；
Preparation method：
（1）Doryopteris concolor (Langsd et Fisch.) Kuhn, bladdernut, saikosaponin C, 10000 years moss, dichotomous fimbristylis herbs are taken by bulk drug proportioning, is mixed, use percentage by weight
The ethanol of concentration 32% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 59 hours, molten every time
Agent consumption is 70 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close
Degree 1.02, filtration, liquid is first washed with water by SP825 large pore resin absorption columns, then with the ethanol of weight percent concentration 16%
Eluant solution SP825 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 16%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 46% as solvent, heating and refluxing extraction 24 times is carried every time
The time is taken for 0.3 hour, each solvent load is 30 times of dregs of a decoction A weight, filtration obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed
Ethanol, is concentrated into relative density 1.06, and filtration, liquid is first washed with water, then use weight by DM-7HP large pore resin absorption columns
The ethanol solution of percent concentration 63% elutes DM-7HP large pore resin absorption columns, collects the ethanol elution of weight percent concentration 63%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Prevent and treat pharmaceutical composition of viral pharyngitis and preparation method thereof
Prevent and treat viral pharyngitis pharmaceutical composition bulk drug composition and weight portion be：Doryopteris concolor (Langsd et Fisch.) Kuhn 86g bladdernut 64g bavins
10000 years moss 52g dichotomous fimbristylis herbs 30g of Hu saponin(e C1g；
Preparation method：
（1）Doryopteris concolor (Langsd et Fisch.) Kuhn, bladdernut, saikosaponin C, 10000 years moss, dichotomous fimbristylis herbs are taken by bulk drug proportioning, is mixed, use percentage by weight
The ethanol of concentration 32% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 59 hours, molten every time
Agent consumption is 70 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close
Degree 1.02, filtration, liquid is first washed with water by SP825 large pore resin absorption columns, then with the ethanol of weight percent concentration 16%
Eluant solution SP825 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 16%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 46% as solvent, heating and refluxing extraction 24 times is carried every time
The time is taken for 0.3 hour, each solvent load is 30 times of dregs of a decoction A weight, filtration obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed
Ethanol, is concentrated into relative density 1.06, and filtration, liquid is first washed with water, then use weight by DM-7HP large pore resin absorption columns
The ethanol solution of percent concentration 63% elutes DM-7HP large pore resin absorption columns, collects the ethanol elution of weight percent concentration 63%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Prevent and treat pharmaceutical composition of viral pharyngitis and preparation method thereof
Prevent and treat viral pharyngitis pharmaceutical composition bulk drug composition and weight portion be：Doryopteris concolor (Langsd et Fisch.) Kuhn 88g bladdernut 60g bavins
10000 years moss 50g dichotomous fimbristylis herbs 36g of Hu saponin(e C1.2g；
Preparation method：
（1）Doryopteris concolor (Langsd et Fisch.) Kuhn, bladdernut, saikosaponin C, 10000 years moss, dichotomous fimbristylis herbs are taken by bulk drug proportioning, is mixed, use percentage by weight
The ethanol of concentration 32% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 59 hours, molten every time
Agent consumption is 70 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close
Degree 1.02, filtration, liquid is first washed with water by SP825 large pore resin absorption columns, then with the ethanol of weight percent concentration 16%
Eluant solution SP825 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 16%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 46% as solvent, heating and refluxing extraction 24 times is carried every time
The time is taken for 0.3 hour, each solvent load is 30 times of dregs of a decoction A weight, filtration obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed
Ethanol, is concentrated into relative density 1.06, and filtration, liquid is first washed with water, then use weight by DM-7HP large pore resin absorption columns
The ethanol solution of percent concentration 63% elutes DM-7HP large pore resin absorption columns, collects the ethanol elution of weight percent concentration 63%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 269g of Example 1, adds starch 383g, mixes, and granulation is dried, plus microcrystalline cellulose 243g, stearic
Sour magnesium 8g, mixes, and is pressed into 2500, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 1900g of Example 2, adds starch 2900g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid
Magnesium, mixes, and encapsulated 9000, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 1240g water-baths and boil molten, add the pharmaceutical composition 53g of embodiment 3, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is -7 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.5cm away from liquid level, and drop speed is optimum condition with every point 60 drop, and the cold of dripping pill surface is blotted with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：Prevent and treat the pharmaceutical composition of viral pharyngitis
Prevent and treat viral pharyngitis pharmaceutical composition bulk drug composition and weight portion be：
83 weight portion of Doryopteris concolor (Langsd et Fisch.) Kuhn, 10000 years weight portions of 65 weight portion dichotomous fimbristylis herb of moss 40.
Embodiment 8：Prevent and treat the pharmaceutical composition of viral pharyngitis
Prevent and treat viral pharyngitis pharmaceutical composition bulk drug composition and weight portion be：
2 weight portion of saikosaponin C, 10000 years weight portions of 36 weight portion dichotomous fimbristylis herb of moss 50.
Embodiment 9：Prevent and treat the pharmaceutical composition of viral pharyngitis
Prevent and treat viral pharyngitis pharmaceutical composition bulk drug composition and weight portion be：
4 weight portion of saikosaponin C, 10000 years weight portions of 50 weight portion dichotomous fimbristylis herb of moss 45.
Experimental example 1：Prevent and treat the experimental study of viral pharyngitis
1 clinical data
1.1 diagnostic criteria
Viral pharyngitis Western medicine diagnostic criteria:By rhinovirus, adenovirus, influenza virus, parainfluenza virus and enterovirus, exhale
Road syncytial virus etc. is inhaled to cause, clinical manifestation for pharynx itch with burning heat sensation, pharyngalgia not substantially, cough rare.The anemofrigid cold traditional Chinese medical science is examined
Disconnected standard:Aversion to cold weight, heating is light, lossless, and headache, podomere is miserable, has a stuffy nose low voice speaking, when clear nasal discharge, larynx itches, coughs, and phlegm is told thin
Color is white, tongue fur Bobai, floating pulse or floating tight.
1.2 case histories are selected
The Western medicine diagnostic criteria for meeting viral pharyngitis and the tcm diagnosis standard for meeting cold disease, after morbidity in 24h
Do not take other similar drugs, and body temperature≤38 DEG C, and exclude gestation, women breast-feeding their children, insane and merge intentionally,
The serious primary patient of Liver and kidney function, hemopoietic system, severe allergy constitution person.It is selected 20 altogether, 17~54 years old age, at random
It is divided into two groups, wherein observation group's (pharmaceutical composition of embodiment 1) 10, man 5, female 5；Control group (Yanyan slice)
10, man 5, female 5.
1.3 treatment methods
Observation group:Pharmaceutical composition（The pharmaceutical composition of embodiment 1）1.4g/ times, 3 times/day, orally；Control group:Yanyan slice
5 pieces/times, 3 times/day of (Shaanxi moral good fortune comes medicine company, lot number 2011119)；Two groups are 5 days 1 courses for the treatment of, in medication 3 days and
Follow-up in 6 days.
1.4 criterions of therapeutical effect
Clinical recovery:Treat clinical symptoms, sign disappearance within 5 d；
It is effective:Clinical observation symptom within 5 d, sign is treated to be obviously improved；
Effectively:Symptom within 5 d, sign is treated to take a favorable turn；
It is invalid:Treat clinical symptoms within 5 d, sign to be not improved, or even aggravate.
2 results
Observation group's clinical cure 4, effective 3, effective 2, invalid 1, total effective rate 90%.Control group clinical cure
2, effective 2, effective 3, invalid 3, total effective rate 70%.Two groups are compared, and it is right that observation group's total effective rate is substantially better than
According to group (P ＜ 0.05).
3 medical records are illustrated
Patient, still so-and-so, female, 38 years old, main cause:Aversion to cold weight, heating are light, and lossless, pharynx is itched, cough, Muscular stiffness 1 day, in
On November 6th, 2013 goes to a doctor.Have a medical check-up:37.6 DEG C of body temperature, 90 times/min of pulse swallows mild hyperaemia, and pharynx rear wall is shown in multiple pouring
Bar folliculus.Thin white fur of tongue, floating and tense pulse.Physico-chemical examination:Blood routine leucocyte 3 × 109/ L, lymphocyte 46%, urine, feces routine
Normally, hepatic and renal function is normal, and electrocardiogram, Chest X-rays are normal.Clinical diagnosis:Viral pharyngitis (Chinese medical discrimination is chill disease).Control
Treat:Pharmaceutical composition（The pharmaceutical composition of embodiment 1）1.4g/ times, 3 times/day, orally, further consultation in 5 days is used in conjunction, without heating, trembled with fear
War, itches without pharynx.Have a medical check-up:36.5 DEG C of body temperature, 75 times/min of pulse is swallowed without hyperemia, and cardiopulmonary (-), tongue nature is light red, and tongue is thin white,
Arteries and veins is thin, and physico-chemical examination is normal.
Claims (8)
1. it is a kind of prevent and treat viral pharyngitis pharmaceutical composition, it is characterised in that be made the composition of the bulk drug of the pharmaceutical composition
It is with weight portion：
Doryopteris concolor (Langsd et Fisch.) Kuhn 86-88 weight portion bladdernut 60-64 weight portion saikosaponin C 1-1.2 10000 years moss 50-52 weight of weight portion
Part dichotomous fimbristylis herb 30-36 weight portions.
2. according to claim 1 it is a kind of prevent and treat viral pharyngitis pharmaceutical composition, it is characterised in that be made the medicine group
The composition and weight portion of the bulk drug of compound be：
87 weight portion bladdernut of Doryopteris concolor (Langsd et Fisch.) Kuhn, 62 weight portion saikosaponin C, 1.1 weight portion, 10000 years weight portion dichotomous fimbristylis herbs 33 of moss 51
Weight portion.
3. according to claim 1 it is a kind of prevent and treat viral pharyngitis pharmaceutical composition, it is characterised in that pharmaceutical composition can
Piece agent or capsule or dripping pill are prepared with using the conventional method of galenic pharmacy.
4. according to claim 1 it is a kind of prevent and treat viral pharyngitis pharmaceutical composition, it is characterised in that pharmaceutical composition with
The preventing and treating viral pharyngitis medicine of chemical drugs or Chinese medicine composition.
5. it is a kind of prevent and treat viral pharyngitis pharmaceutical composition preparation method, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Doryopteris concolor (Langsd et Fisch.) Kuhn 86-88 weight portion bladdernut 60-64 weight portion saikosaponin Cs 1-1.2
10000 years moss 50-52 weight portion dichotomous fimbristylis herb 30-36 weight portions of weight portion；
Preparation method：
（1）Doryopteris concolor (Langsd et Fisch.) Kuhn, bladdernut, saikosaponin C, 10000 years moss, dichotomous fimbristylis herbs are taken by bulk drug proportioning, is mixed, use percentage by weight
The ethanol of concentration 32% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 59 hours, molten every time
Agent consumption is 70 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close
Degree 1.02, filtration, liquid is first washed with water by SP825 large pore resin absorption columns, then with the ethanol of weight percent concentration 16%
Eluant solution SP825 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 16%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 46% as solvent, heating and refluxing extraction 24 times is carried every time
The time is taken for 0.3 hour, each solvent load is 30 times of dregs of a decoction A weight, filtration obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed
Ethanol, is concentrated into relative density 1.06, and filtration, liquid is first washed with water, then use weight by DM-7HP large pore resin absorption columns
The ethanol solution of percent concentration 63% elutes DM-7HP large pore resin absorption columns, collects the ethanol elution of weight percent concentration 63%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. according to claim 5 it is a kind of prevent and treat viral pharyngitis pharmaceutical composition preparation method, it is characterised in that press
It is prepared by following steps：
The composition and weight portion of bulk drug be：The weight portion of 87 weight portion bladdernut of Doryopteris concolor (Langsd et Fisch.) Kuhn, 62 weight portion saikosaponin C 1.1
10000 years weight portions of 51 weight portion dichotomous fimbristylis herb of moss 33；
Preparation method：
（1）Doryopteris concolor (Langsd et Fisch.) Kuhn, bladdernut, saikosaponin C, 10000 years moss, dichotomous fimbristylis herbs are taken by bulk drug proportioning, is mixed, use percentage by weight
The ethanol of concentration 32% takes as solvent in 29 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 59 hours, molten every time
Agent consumption is 70 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close
Degree 1.02, filtration, liquid is first washed with water by SP825 large pore resin absorption columns, then with the ethanol of weight percent concentration 16%
Eluant solution SP825 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 16%, reclaim ethanol, and concentration is dry
It is dry, obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 46% as solvent, heating and refluxing extraction 24 times is carried every time
The time is taken for 0.3 hour, each solvent load is 30 times of dregs of a decoction A weight, filtration obtains dregs of a decoction B and extract solution B, and extract solution B is reclaimed
Ethanol, is concentrated into relative density 1.06, and filtration, liquid is first washed with water, then use weight by DM-7HP large pore resin absorption columns
The ethanol solution of percent concentration 63% elutes DM-7HP large pore resin absorption columns, collects the ethanol elution of weight percent concentration 63%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. according to claim 5 it is a kind of prevent and treat viral pharyngitis pharmaceutical composition preparation method, it is characterised in that medicine
Compositions can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. according to claim 5 it is a kind of prevent and treat viral pharyngitis pharmaceutical composition preparation method, it is characterised in that medicine
Compositions and chemical drugs or Chinese medicine composition preventing and treating viral pharyngitis medicine.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560997A (en) * | 2016-01-25 | 2016-05-11 | 济南星懿医药技术有限公司 | Medicine composition for treating pharyngitis |
| CN106038633A (en) * | 2016-06-30 | 2016-10-26 | 济南星懿医药技术有限公司 | Pharmaceutical composition capable of treating breast cancer |
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2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560997A (en) * | 2016-01-25 | 2016-05-11 | 济南星懿医药技术有限公司 | Medicine composition for treating pharyngitis |
| CN106038633A (en) * | 2016-06-30 | 2016-10-26 | 济南星懿医药技术有限公司 | Pharmaceutical composition capable of treating breast cancer |
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