CN106540027A - It is a kind of to prevent and treat pharmaceutical composition of laryngitis and preparation method thereof - Google Patents
It is a kind of to prevent and treat pharmaceutical composition of laryngitis and preparation method thereof Download PDFInfo
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- CN106540027A CN106540027A CN201611133099.8A CN201611133099A CN106540027A CN 106540027 A CN106540027 A CN 106540027A CN 201611133099 A CN201611133099 A CN 201611133099A CN 106540027 A CN106540027 A CN 106540027A
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 55
- 201000008197 Laryngitis Diseases 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000003814 drug Substances 0.000 claims abstract description 48
- 229940079593 drug Drugs 0.000 claims abstract description 36
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- 238000000105 evaporative light scattering detection Methods 0.000 claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 140
- 239000000284 extract Substances 0.000 claims description 56
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- 238000010521 absorption reaction Methods 0.000 claims description 28
- 238000000605 extraction Methods 0.000 claims description 28
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- 239000002904 solvent Substances 0.000 claims description 28
- 239000012467 final product Substances 0.000 claims description 24
- 238000001914 filtration Methods 0.000 claims description 21
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- 239000012141 concentrate Substances 0.000 claims description 14
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- 235000016831 stigmasterol Nutrition 0.000 description 2
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- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/10—Bryophyta (mosses)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of prevent and treat pharmaceutical composition of laryngitis and preparation method thereof, pharmaceutical composition of the present invention is with prairie fire rope, bladdernut, HPLC-ELSD, katydid, 10000 years moss as bulk drug, proportioning is formed, and routinely can be made various formulations by preparation process, be prevented and treated laryngitis evident in efficacy.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of prevent and treat pharmaceutical composition of laryngitis and preparation method thereof.
Background technology
Laryngopharyngeal reflux disease (laryngopharyngeal reflux disease, LPRD) is by more next in recent years
More concerns.In LPRD, rear portion laryngitis is modal disease, and its clinical manifestation is obscured, and common symptom has pharyngeal different
Thing sense, hawk repeatedly, sore-throat, sound change etc..It is presently recommended that treatment except improving dietary, it is outer to give up tobacco and wine etc.,
Mainly antiacid treatment, including the application of H2 acceptor inhibitors and proton pump inhibitor.But it is current to the curative effect of antiacid treatment
Dispute is still suffered from, some patients' curative effect is not good enough, some reasons are probably that pepsic reflux is also assisted in addition to acid reflux
Its morbidity is relevant.Laryngopharyngeal reflux rear portion laryngitis belongs to traditional Chinese medicine globus hysteriocus disease category.The record earliest to the disease is Zhang Zhong
Scape, in the banxia houpu decoction of its treatment " married woman pharynx in if any process a small slice of meat ", i.e., to control the panacea tuber of pinellia of vomitting as main ingredient.Illustrate that ancient times cure
Although family due to the limitation of diagnostic techniques, the pathology in throat and laryngopharynx portion cannot be observed, have recognized that foreign body in pharynx sense with
There is correlation in alimentary canal reflux.Taste are lacked of proper care, and stomach Qi upward reversal is general in phlegm wet, tie stagnant in pharynx so that sarolemma fertilizer is swollen, long and
Do not heal, and cause pharynx to hinder like thing, choke between larynx.Although alimentary canal reflux is the sick Etiological, the performance of pathology is presented many
Sample, individual difference is clearly.
Bladdernut：This product is Palmae herba fibraureae recisae platymiscium herba fibraureae recisae Daemonorops margaritae（Hance）Becc.
[Calamus margaritae Hance ］ stem.Whole year can adopt, and segment is dried.【Nature and flavor】Bitter；It is mild-natured.【Function master
Control】Expelling parasite；It is treating stranguria；Wind dispelling pain relieving.Main roundworm；Pinworm；Taeniasis；Urine leaching pain；Dentalgia.【Former phytomorph】Herba fibraureae recisae, spinosity
Big liana.Stem is upright at the beginning, after climb up by holding on to shape.Leaf pinniform is totally cleaved, total length 2-3m, and rachis top extends into the fine whip of tool claw-like thorn；
The nearly opposite of sliver, 50-75 pair, strip lanceolar, long 25-45cm, wide l-2cm, tip are tapering, and the rachis back side differs in size down
The thorn of curved or rigidness；Leaf sheath is without fine whip but has flat thorn.Spadix is enclose for spathe before blooming, in spindle, long 25-
30cm, Zhu Duan shape of tail is tapering, and the close straight thrust by brown, flat in 1 piece of outside, the spathe of the inside are pierced less or stingless, yielded positive results
Spathe comes off afterwards.Rachilla on male inflorescence is intensive, is about 3cm, spends intensive, and the long round shape of male flower is avette, long 5mm；Calyx cup
Shape, shallow 3 tooth；Corolla 3 splits, and about 2 times are longer than calyx；Stamen 6, is about 3.5mm, involucre tazza shape.Female flower：Calyx short cylinder shaped, first
Hold 3 fissures；Petal lanceolar, long be about calyx 2 times；Ovary is avette, 3 pieces of column cap.Fruit is spherical, diameter 1.8-2cm, has
The scale of 18-20 row files, scale have 10-20 on per 1 row, yellow and it is bright, have groove.The seed kidney shape is spherical.Florescence 5
Month, the fruiting period 6-10 month.Record in dictionary of medicinal plant.
Prairie fire rope：This product be Tiliaceae load bar platymiscium comospore bilobed grewia Grewia eriocarpa Juss.
G.lantsangensis Hu ］ root white skin.Autumn, winter take root, strip root skin, remove cork, and segment is dried.【Property
Taste】It is puckery；Slight bitter；It is cool.【Indication】Hemostasis；Synthetism；Myogenic；Removing toxic substances.Main traumatism and bleeding；Weapons are damaged；Fracture；Boil is red
It is swollen.【Original shape state】Comospore bilobed grewia shrub or dungarunga, up to 8m.Spray is by the starlike soft fine hair of taupe.Leaf alternate；Shi Bing
Long 5-10mm；Stipule wire lanceolar, long 5-10mm；Blade papery, tiltedly avette to ovate Long Circle, long 6-13cm, wide 3-
6cm, tip is tapering or anxious point, base portion deflection, tiltedly circular or bevel shape, above scattered stellate hair, it is dry after become pitchy, below quilt
The starlike soft fine hair of grey, there is serration at edge；Trinervious two lateral vein rises 3/4 up to leaf length, and the middle arteries first half has lateral vein 3-4
It is right.Cyme 1-3 branches armpit is given birth to, long 1.5-3cm, the long 3-8mm of common peduncle；The long 3-5mm of anthocaulus；Bract lanceolar；Flower both sexes；Calyx
The long and narrow circle of piece, long 6-8mm, inside and outside two sides is without hair；The long 3mm of petal；Body of gland is short and small；Androgynophore is by hair；Stamen is from life, long
It is short to differ, it is shorter than sepal；By hair, style has a pubescence to ovary, column cap peltate, and 4 shallow split or do not divide.Drupe is subsphaeroidal, diameter
6-8mm, by stellate hair, has shallow ridges.Record in dictionary of medicinal plant.
Katydid：This product is that Tettigoniidae katydid belongs to animal katydid Gampsaocleis gratiosa Brunner
Wattenwyl. entirety.Summer, autumn catch, and catch rear boiling water and scald dead, dry or dry.【Nature and flavor】Taste is pungent；Micro-sweet；It is mild-natured.【Work(
Can cure mainly】Inducing diuresis for removing edema；Remove obstruction in channels to relieve pain.Main oedema oliguria；Waist and knee swells and ache；Weak foot due to dampness.【Proterties】It is in Long Circle that this product is all, grey
Green or yellowish-brown.Slightly rounded, 1 pair, the compound eye of head, oval, feeler 1 pair, length are whiplike, come off more；Pronotary is slightly in elongated
Cylinder, middle metathorax is by wing；Pereiopoda 3 pairs, comes off more, and metapedes is larger.Gas raw meat.Record in dictionary of medicinal plant.
10000 years moss：This product is ten thousand Nian Xian sections, 10000 years Rhodobryum plants, 10000 years moss Climacium dendroides（Hedw.）
The plant of Web.et Mohr ［ Leskea dendroides Hedw. ］.Spring, summer harvesting, clean, dry.【Nature and flavor】It is bitter；
It is cold.【Indication】Removing damp-heat；Stimulate the circulation of the blood and cause the muscles and joints to relax.Main rheumatism internal lesion caused by overexertion；Arthralgia and myalgia.【Chemical analysis】Containing cupreol (β-
Sitosterol), stigmasterol (stigmasterol), ergosterol (ergosterol), campesterol (campesterol),
Cyclolaudenol (cyclolaudenol), 31- remove first cyclolaudenol (31-norcyclolaudenol), and metal
Elemental iron, manganese, zinc, copper etc..【Former phytomorph】Plant is thick in tree-like, and subterranean stem crawls to grow wild, tool rhizoid and film quality squama
Shape leaflet.The aerial stem of plant is upright, multi-branched, up to 15-20cm, the densely covered green palea of branch.The leaf and branched base part on stem top
, in wide ovate triangle or ovum shape lanceolar, base portion is slightly downward for blade.Middle rib is single, terminates up to before blade tip, and blade top is thin
The narrow rhombus of born of the same parents, leaf corner cell are circular, semi-transparent clear.The blade on branch top is less, long and narrow lanceolar, leaf edge sawtooth up in
Middle part.Dioecism.Seta is elongated, long 2-4cm, red；Sporangium is upright, and long cylindricality has more；The female shape of the high circle of opercule；Capsule balaclava
Shape, the full sporangium of clad.Record in dictionary of medicinal plant.
HPLC-ELSD（Phytolaccasaponin A）：CAS 65497-07-6, molecular formula C42H66O16, molecular weight
826.96.【Biologically active】Anti-inflammatory activity.【Ingredient origin】Phytolacca acinosa Phytolacca esculenta [Syn.
Phytolacca acinosa]。
1 bulk drug chemical constitution：
HPLC-ELSD（Phytolaccasaponin A）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition for effectively preventing and treating laryngitis and its
Preparation method.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for making the bulk drug of the pharmaceutical composition for preventing and treating laryngitis be：
Prairie fire rope 356-358 weight portion bladdernut 360-364 weight portion HPLC-ELSD 12-14 weight portion katydid 350-352
10000 years moss 330-336 weight portions of weight portion.
The pharmaceutical composition for preventing and treating laryngitis is preferably used in, is made up of the bulk drug of following weight portion：
Prairie fire rope 357 weight portion bladdernut, 362 weight portion HPLC-ELSD, 13 weight portion katydid, 351 weight portion, 10000 years moss 333
Weight portion.
A kind of pharmaceutical composition for preventing and treating laryngitis, it is characterised in that pharmaceutical composition can adopt the conventional method of galenic pharmacy
Prepare piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for preventing and treating laryngitis, it is characterised in that the preventing and treating that pharmaceutical composition is constituted with chemical drugs or Chinese medicine
Laryngitis medicine.
A kind of preparation method of the pharmaceutical composition for preventing and treating laryngitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Prairie fire rope 356-358 weight portion bladdernut 360-364 weight portion esculentosides
A12-14 weight portion katydid 350-352 10000 years moss 330-336 weight portions of weight portion；
Preparation method：
（1）Prairie fire rope, bladdernut, HPLC-ELSD, katydid, 10000 years moss are taken by bulk drug proportioning, is mixed, it is dense with percentage by weight
28% ethanol being spent as solvent, being taken in 35 DEG C of temperature extractions, extraction time is 8 times, and each extraction time is 57 hours, each solvent
52 times for bulk drug gross weight of consumption, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into relative density
1.08, filtration, liquid are first washed with water by LK001 large pore resin absorption columns, then molten with 18% ethanol of weight percent concentration
Liquid wash-out LK001 large pore resin absorption columns, collection 18% ethanol eluate of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 57% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time
The time is taken for 0.2 hour, 26 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 77% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 77% ethanol elution of weight percent concentration
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for preventing and treating laryngitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：357 weight portion bladdernut of prairie fire rope, 362 weight portion HPLC-ELSD, 13 weight portion
351 weight portion of katydid, 10000 years 333 weight portions of moss；
Preparation method：
（1）Prairie fire rope, bladdernut, HPLC-ELSD, katydid, 10000 years moss are taken by bulk drug proportioning, is mixed, it is dense with percentage by weight
28% ethanol being spent as solvent, being taken in 35 DEG C of temperature extractions, extraction time is 8 times, and each extraction time is 57 hours, each solvent
52 times for bulk drug gross weight of consumption, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into relative density
1.08, filtration, liquid are first washed with water by LK001 large pore resin absorption columns, then molten with 18% ethanol of weight percent concentration
Liquid wash-out LK001 large pore resin absorption columns, collection 18% ethanol eluate of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 57% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time
The time is taken for 0.2 hour, 26 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 77% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 77% ethanol elution of weight percent concentration
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for preventing and treating laryngitis, it is characterised in that pharmaceutical composition can adopt galenic pharmacy
Conventional method prepare piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for preventing and treating laryngitis, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine
Composition prevents and treats laryngitis medicine.
It is evident in efficacy that pharmaceutical composition prevents and treats laryngitis.
Specific embodiment
Embodiment 1：Prevent and treat pharmaceutical composition of laryngitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of laryngitis be：Prairie fire rope 357g bladdernut 362g Phytolacca acinosa soaps
Glycosides A13g katydids 10000 years moss 333g of 351g；
Preparation method：
（1）Prairie fire rope, bladdernut, HPLC-ELSD, katydid, 10000 years moss are taken by bulk drug proportioning, is mixed, it is dense with percentage by weight
28% ethanol being spent as solvent, being taken in 35 DEG C of temperature extractions, extraction time is 8 times, and each extraction time is 57 hours, each solvent
52 times for bulk drug gross weight of consumption, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into relative density
1.08, filtration, liquid are first washed with water by LK001 large pore resin absorption columns, then molten with 18% ethanol of weight percent concentration
Liquid wash-out LK001 large pore resin absorption columns, collection 18% ethanol eluate of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 57% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time
The time is taken for 0.2 hour, 26 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 77% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 77% ethanol elution of weight percent concentration
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Prevent and treat pharmaceutical composition of laryngitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of laryngitis be：Prairie fire rope 356g bladdernut 364g Phytolacca acinosa soaps
Glycosides A12g katydids 10000 years moss 330g of 352g；
Preparation method：
（1）Prairie fire rope, bladdernut, HPLC-ELSD, katydid, 10000 years moss are taken by bulk drug proportioning, is mixed, it is dense with percentage by weight
28% ethanol being spent as solvent, being taken in 35 DEG C of temperature extractions, extraction time is 8 times, and each extraction time is 57 hours, each solvent
52 times for bulk drug gross weight of consumption, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into relative density
1.08, filtration, liquid are first washed with water by LK001 large pore resin absorption columns, then molten with 18% ethanol of weight percent concentration
Liquid wash-out LK001 large pore resin absorption columns, collection 18% ethanol eluate of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 57% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time
The time is taken for 0.2 hour, 26 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 77% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 77% ethanol elution of weight percent concentration
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Prevent and treat pharmaceutical composition of laryngitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of laryngitis be：Prairie fire rope 358g bladdernut 360g Phytolacca acinosa soaps
Glycosides A14g katydids 10000 years moss 336g of 350g；
Preparation method：
（1）Prairie fire rope, bladdernut, HPLC-ELSD, katydid, 10000 years moss are taken by bulk drug proportioning, is mixed, it is dense with percentage by weight
28% ethanol being spent as solvent, being taken in 35 DEG C of temperature extractions, extraction time is 8 times, and each extraction time is 57 hours, each solvent
52 times for bulk drug gross weight of consumption, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into relative density
1.08, filtration, liquid are first washed with water by LK001 large pore resin absorption columns, then molten with 18% ethanol of weight percent concentration
Liquid wash-out LK001 large pore resin absorption columns, collection 18% ethanol eluate of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 57% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time
The time is taken for 0.2 hour, 26 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 77% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 77% ethanol elution of weight percent concentration
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
1 pharmaceutical composition 97g of Example, adds starch 158g, mixes, and granulation is dried, plus microcrystalline cellulose 38g, stearic acid
Magnesium 5g, mixes, is pressed into 600, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
2 pharmaceutical composition 190g of Example, adds starch 140g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid
Magnesium, mixes, encapsulated 800, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 350g water-baths and boil molten, add 3 pharmaceutical composition 14g of embodiment, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is -4 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip are 2.6cm away from liquid level, and drop speed is per dividing 55 drops as optimum condition, to blot the cold of dripping pill surface with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：Prevent and treat the pharmaceutical composition of laryngitis
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of laryngitis be：
383 weight portion katydid of prairie fire rope, 365 weight portion, 10000 years 340 weight portions of moss.
Embodiment 8：Prevent and treat the pharmaceutical composition of laryngitis
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of laryngitis be：
12 weight portion katydid of HPLC-ELSD, 136 weight portion, 10000 years 250 weight portions of moss.
Embodiment 9：Prevent and treat the pharmaceutical composition of laryngitis
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of laryngitis be：
14 weight portion katydid of HPLC-ELSD, 350 weight portion, 10000 years 345 weight portions of moss.
Experimental example 1：Prevent and treat the experimental study of laryngitis
1 physical data
All cases are hospital of city hals,Nasen und Ohrenheilkunde outpatient, totally 25, wherein the male sex 15, women 10；Age
26-55 year, average 36.35 years old；The course of disease -2 years on the 10th.All patients are relaxed as foreign matter obstruction, feed are not hindered or disliked with pharyngeal
Take as main performance, wherein with itching throat and dry cough person 9, sound abnormal change person 8 of occurring together, with pharyngalgia person 8.All cases are equal
The inspection of Jing electrolaryngoscopes, swelling 10 under Shao Jian areas congestion and edema 8, postcricoid area swelling 7, vocal cords and glottis.All cases
The diseases such as esophageal tumor, niche are excluded on inspection.Treatment group 13 is randomly divided into, control group 12, two groups of cases are typically provided
Material no difference of science of statistics (P>0.05), with comparativity.
2 treatment methods
2.1 treatment group
Combination of oral medication (1 pharmaceutical composition of embodiment), square medicine:1 pharmaceutical composition 5g of embodiment.The glutted person of the middle part of gastric cavity, plus
Buddha's hand 5g；Loose stool person, plus coptis 5g；White and greasy fur person, plus eupatorium 8g.Daily 1 dose, 2 decoctions sooner or later.January is 1 course for the treatment of, altogether
2 courses for the treatment of of treatment.
2.2 control group
Omeprazole enteric-coated capsules, each 20mg are oral, and 2 times a day (before early, supper)；Dispersible Mosapride citrate tablets, often
Secondary 5mg is oral, and 3 times a day.January is 1 course for the treatment of, treats 2 courses for the treatment of altogether.
3 observation of curative effect
3.1 criterion of therapeutical effect
Cure:Pharynx foreign body sensation disappears, and pronounces distinctly.Electrolaryngoscope checks throat without hyperemia without swelling.Follow-up 3 months is without recurrence.
Take a turn for the better:Pharynx foreign body sensation disappears, and pronounces distinctly.Electrolaryngoscope check part sign mitigates.
It is invalid:Symptom and sign is not improved.
3.2 result
In 25 cases, treatment group totally 13 cures 8, takes a turn for the better 4, invalid 1, total effective rate 92.31%；Control group totally 12
Example, cures 3, takes a turn for the better 4, invalid 5, total effective rate 58.33%.Two groups of total effective rates compare, P<0.05, difference has system
Meter learns meaning.
Claims (8)
1. a kind of pharmaceutical composition for preventing and treating laryngitis, it is characterised in that make the composition and weight of the bulk drug of the pharmaceutical composition
Part it is：
Prairie fire rope 356-358 weight portion bladdernut 360-364 weight portion HPLC-ELSD 12-14 weight portion katydid 350-352
10000 years moss 330-336 weight portions of weight portion.
2. a kind of pharmaceutical composition for preventing and treating laryngitis according to claim 1, it is characterised in that make the pharmaceutical composition
The composition and weight portion of bulk drug be：
Prairie fire rope 357 weight portion bladdernut, 362 weight portion HPLC-ELSD, 13 weight portion katydid, 351 weight portion, 10000 years moss 333
Weight portion.
3. a kind of pharmaceutical composition for preventing and treating laryngitis according to claim 1, it is characterised in that pharmaceutical composition can be adopted
The conventional method of galenic pharmacy prepares piece agent or capsule or dripping pill.
4. a kind of pharmaceutical composition for preventing and treating laryngitis according to claim 1, it is characterised in that pharmaceutical composition and chemical drugs
Or Chinese medicine composition prevent and treat laryngitis medicine.
5. a kind of preparation method of the pharmaceutical composition for preventing and treating laryngitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Prairie fire rope 356-358 weight portion bladdernut 360-364 weight portion esculentosides
A12-14 weight portion katydid 350-352 10000 years moss 330-336 weight portions of weight portion；
Preparation method：
（1）Prairie fire rope, bladdernut, HPLC-ELSD, katydid, 10000 years moss are taken by bulk drug proportioning, is mixed, it is dense with percentage by weight
28% ethanol being spent as solvent, being taken in 35 DEG C of temperature extractions, extraction time is 8 times, and each extraction time is 57 hours, each solvent
52 times for bulk drug gross weight of consumption, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into relative density
1.08, filtration, liquid are first washed with water by LK001 large pore resin absorption columns, then molten with 18% ethanol of weight percent concentration
Liquid wash-out LK001 large pore resin absorption columns, collection 18% ethanol eluate of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 57% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time
The time is taken for 0.2 hour, 26 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 77% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 77% ethanol elution of weight percent concentration
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for preventing and treating laryngitis according to claim 5, it is characterised in that by following step
It is rapid to prepare：
The composition and weight portion of bulk drug be：357 weight portion bladdernut of prairie fire rope, 362 weight portion HPLC-ELSD, 13 weight portion
351 weight portion of katydid, 10000 years 333 weight portions of moss；
Preparation method：
（1）Prairie fire rope, bladdernut, HPLC-ELSD, katydid, 10000 years moss are taken by bulk drug proportioning, is mixed, it is dense with percentage by weight
28% ethanol being spent as solvent, being taken in 35 DEG C of temperature extractions, extraction time is 8 times, and each extraction time is 57 hours, each solvent
52 times for bulk drug gross weight of consumption, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into relative density
1.08, filtration, liquid are first washed with water by LK001 large pore resin absorption columns, then molten with 18% ethanol of weight percent concentration
Liquid wash-out LK001 large pore resin absorption columns, collection 18% ethanol eluate of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 57% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time
The time is taken for 0.2 hour, 26 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 77% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 77% ethanol elution of weight percent concentration
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for preventing and treating laryngitis according to claim 5, it is characterised in that drug regimen
Thing can adopt the conventional method of galenic pharmacy to prepare piece agent or capsule or dripping pill.
8. a kind of preparation method of the pharmaceutical composition for preventing and treating laryngitis according to claim 5, it is characterised in that drug regimen
Thing prevents and treats laryngitis medicine with chemical drugs or Chinese medicine composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611133099.8A CN106540027A (en) | 2016-12-10 | 2016-12-10 | It is a kind of to prevent and treat pharmaceutical composition of laryngitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611133099.8A CN106540027A (en) | 2016-12-10 | 2016-12-10 | It is a kind of to prevent and treat pharmaceutical composition of laryngitis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106540027A true CN106540027A (en) | 2017-03-29 |
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ID=58397087
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| CN201611133099.8A Withdrawn CN106540027A (en) | 2016-12-10 | 2016-12-10 | It is a kind of to prevent and treat pharmaceutical composition of laryngitis and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN106540027A (en) |
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2016
- 2016-12-10 CN CN201611133099.8A patent/CN106540027A/en not_active Withdrawn
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Application publication date: 20170329 |