CN106539838A - Prevent and treat the pharmaceutical composition of neurodermatitis - Google Patents
Prevent and treat the pharmaceutical composition of neurodermatitis Download PDFInfo
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a kind of prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof, pharmaceutical composition of the present invention is with poly- algae, purple fiber crops, cycloartanol, acetovanillone, black gland loosestrife as bulk drug, proportioning is formed, routinely various formulations can be made by preparation process, prevent and treat neurodermatitis evident in efficacy.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for preventing and treating neurodermatitis and its preparation
Method.
Background technology
Neurodermatitis, the traditional Chinese medical science are referred to as neurodermatitis, often occur in neck, patella ulnaris joint, tail energy portion etc..Show as play
Itch, skin of scratching for a long time can thicken to form papule block, and lichenification then, area have pigmentation for 1 to several centimeters, often have bran
Furfur can affect sleep, not heal in the course of disease slow constant year.This disease is divided into wind-heat phase, insufficiency of the spleen with overabundance of dampness phase, liver depression blood addiction phase by the traditional Chinese medical science, and one
As go to a doctor when after two phases it is in the majority.
The neurodermatitis cause of disease is not completely clear and definite, but fatigue, it is nervous and scratch, rub, it is Exposure to Sunlight, many
Sweat, drink or the physical stimulating factor of mechanicalness can inspire the disease, aggravate disease.The course of disease is delayed, and is easy to recurrence.It is logical
Cross herbal fumigation and quickly can fully expand human peripheral capilary and rete vasculosum, improve human bloodstream state quickly, especially
It is the microcirculating state for being obviously improved human body.Under smoked swallow dipping state, because heat energy dissipates, drug microparticles easily pass through skin
Directly absorb, into passages through which vital energy circulates blood network, pleased cloth whole body and play the therapeutic action of medicine.
Poly- algae：This product is Haloragaceae Myriophyllum plant spike watermifoil Ntruiogtkkyn soucatyn L.'s
Herb.From April to October, harvested 1 time every 2 months, harvest in pond 1/2 poly- algae every time, dry or dry.【Nature and flavor】Taste
It is sweet；It is light；It is cold in nature.【Indication】Heat-clearing；Cool blood, removing toxic substances.Main pyreticosis polydipsia；Dysentery；Erysipelas；Boil；Scald.【Chemistry into
Part】Containing substantial amounts of chlorophyllide (chlorophyllide).【Original shape state】The perennial heavy pasture and water sheet of spike watermifoil.
Root-like stock is crawled, raw fibrous root on section.Stem cylinder, elongation, normal branch are different according to the depth of water and length differs, internode length 3-
4cm.4 pieces of leaf is verticillate；Stockless；Bottle green, to lanceolar, long 2-3cm, pinniform drastic crack, sliver are linear, fine and closely woven, 13- for oblong
More than 20 is right, alternate and nearly opposite.Spike basidixed, long 5-10cm are stood upright in the water surface, fruiting period submerged in the water；Flower unisexuality, 4 to
Most verticillate, male and female flowering homophyletics；Male flower occupies top, and bract green, edge are red, and Long Circle, squamella are avette, calyx pipe mitriform,
Calyx 4, ovate triangle, petal 4, red greening, navicular cochlear are caducous, stamen 8, light green or yellow green, long 2mm；Female flower
Give birth to portion, calyx pipe is several truncate or has a shallow tooth, petal 4, and oval, tip are blunt, pink, caducous, and ovary is the next, Room 4, column cap 4,
Pinniform, outwards inverts.Really spherical, diameter 1.5-3mm is divided into 4 mericarps.The month at florescence 4-10.Record in dictionary of medicinal plant.
Purple fiber crops：This product is purple fiber crops platymiscium purple fiber crops Oreocnide frutescens (Thunb.) Miq. ［ Ur- of Urticaceae
Tica frutescens Thunb. ］ complete stool.Summer, autumn harvesting, clean, dry.【Nature and flavor】It is sweet；It is cool in nature.【Indication】
It is clearing heat and detoxicating；The promoting flow of qi and blood circulation；Promoting eruption.Main cold, fever；Traumatic injury；Toothache；Measles without adequate eruption；Early stage of pyogenic infection of skin.【Proterties】Complete stool hairiness,
Up to lm.There is rib groove on stem.Leaf shrinkage, ovate Long Circle or ovum shape lanceolar after flattening, long 4-12cm, wide 1.7-5cm, tip
It is tapering, base portion wedge shape, there is sawtooth at edge；The long 1-4cm of petiole.Fruit is avette.Gas is micro-, and taste is micro- sweet.Record in dictionary of medicinal plant.
Black gland loosestrife：This product is the black gland loosestrife Lysimachia heterogenea of Primulaceae Lysimachia plant
Klatt. the herb of [L.paludicola Hemsl.].Summer, autumn harvesting, dry.【Nature and flavor】It is bitter；It is pungent；It is mild-natured.【Function master
Control】Promoting blood circulation；Antidote against snake bite.Main amenorrhoea；Venomous snake bite.【Former phytomorph】Perennial herb.Stem is upright, high 40-80cm, complete stool
Without hair.Four prismatics, seamed edge have narrow wing and black gland point, and middle part above multi-branched, branch pole are carried out.Basal leaf piece cochlear, long 1-
6cm, wide 0.6-3.8cm, tip circle are blunt, and base portion is downward into wing handle, and flower is not present often；Stem leaf opposite, stockless；Blade drapes over one's shoulders pin
Shape or wire lanceolar, few long round shape lanceolar, long 4-13cm, wide 1-3cm, tip are slightly sharp sharp or blunt, and base portion is blunt or ear
Half armful of stem, the granular gland point of the close raw black in two sides.Raceme is born in stem end and branch end, long 8-13cm；Bract is lobate, lanceolar,
Gradual change is little upwards, is longer than or near etc. is longer than bennet；The long 3-5mm of bennet；The long 4-5mm of calyx, 5 divisions closely reach base portion, sliver wire
Lanceolar, tip is tapering and crimps to back：Corolla white, is about 7mm, and base portion symphysis part is about 2.5mm, 5 divisions, sliver
Ovate Long Circle；Vertebra stamen 5, the middle part of filigree adhesion to corolla closely isometric with corolla, separate section are about 3mm, flower pesticide gland shape,
It is about 1.5mm, connective tip tool callosity shape tip；Ovary is without hair, upper, and Room 1, style are about 6mm, and column cap expands.Capsule ball
Shape, diameter about 3mm.The black purple of seed.The month at florescence 5-7, the fruiting period 8-10 month.Record in dictionary of medicinal plant.
Cycloartanol（Cycloartanol）：CAS 4657-58-3, molecular formula C30H52O, molecular weight 428.75.
【Pharmacological action】With antiinflammatory action.【Ingredient origin】Soya-bean oil, the fruit of Chinese wolfberry, Huo Yang le, the wall fern.
Acetovanillone（Acetovanillone）：CAS 498-02-2, molecular formula C9H10O3, molecular weight 166.18.【Medicine
Reason is acted on】Choleretic effect is shown as to rabbit.There are contraction rat uterus and suppress the effect of the frog heart.【Purposes】It is stable, cholagogic, effect
In uterus.【Ingredient origin】Ginseng section plant Huang side Picrorrhiza kurrooa Royle ex Benth, Apocynaceae plant
Thing, apocynum cannabinum Apocynum cannabinum L. rhizomes, Androsace umbellata leaf tea flower Apocynum
Androsaemifolium Linn. rhizomes.
2 bulk drug chemical constitutions：
Acetovanillone（Acetovanillone）Cycloartanol（Cycloartanol）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of drug regimen for effectively preventing and treating neurodermatitis
Thing and preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for making the bulk drug of the pharmaceutical composition for preventing and treating neurodermatitis be：
Poly- algae 520-530 weight portions purple fiber crops 512-520 weight portion cycloartanol 24-28 weight portion acetovanillone 20-26
The black gland loosestrife 540-550 weight portions of weight portion.
The pharmaceutical composition for preventing and treating neurodermatitis is preferably used in, is made up of the bulk drug of following weight portion：
The black gland of 525 weight portion of the poly- algae numb 517 weight portion cycloartanol of purple, 26 weight portion acetovanillone, 23 weight portion is precious
545 weight portion of pearl dish.
A kind of pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition can adopt the normal of galenic pharmacy
Rule method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine
Prevent and treat neurodermatitis medicine.
A kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Poly- algae 520-530 weight portions purple fiber crops 512-520 weight portion cycloartanols
The black gland loosestrife 540-550 weight portions of 24-28 weight portion acetovanillone 20-26 weight portions；
Preparation method：
（1）Poly- algae, purple fiber crops, cycloartanol, acetovanillone, black gland loosestrife are taken by bulk drug proportioning, is mixed, with weight hundred
Divide 29% ethanol of specific concentration as solvent, 32.5 DEG C of temperature extractions take, and extraction time is 10 times, and each extraction time is 20 hours, often
33 times for bulk drug gross weight of secondary solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid are first washed with water, then use weight percent concentration by LKS02 large pore resin absorption columns
47.5% ethanol solution elutes LKS02 large pore resin absorption columns, collects 47.5% ethanol eluate of weight percent concentration, reclaims second
Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 65% ethanol of weight percent concentration as solvent, heating and refluxing extraction 7 times, is carried every time
The time is taken for 0.3 hour, 20 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, liquid is first washed with water, then uses weight by DM18 large pore resin absorption columns
84% ethanol solution of percent concentration elutes DM18 large pore resin absorption columns, collects 84% ethanol eluate of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that make as follows
It is standby：
The composition and weight portion of bulk drug be：Purple numb 517 weight portion cycloartanol, 26 weight portion of 525 weight portion of poly- algae
Black 545 weight portion of gland loosestrife of 23 weight portion of acetovanillone；
Preparation method：
（1）Poly- algae, purple fiber crops, cycloartanol, acetovanillone, black gland loosestrife are taken by bulk drug proportioning, is mixed, with weight hundred
Divide 29% ethanol of specific concentration as solvent, 32.5 DEG C of temperature extractions take, and extraction time is 10 times, and each extraction time is 20 hours, often
33 times for bulk drug gross weight of secondary solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid are first washed with water, then use weight percent concentration by LKS02 large pore resin absorption columns
47.5% ethanol solution elutes LKS02 large pore resin absorption columns, collects 47.5% ethanol eluate of weight percent concentration, reclaims second
Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 65% ethanol of weight percent concentration as solvent, heating and refluxing extraction 7 times, is carried every time
The time is taken for 0.3 hour, 20 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, liquid is first washed with water, then uses weight by DM18 large pore resin absorption columns
84% ethanol solution of percent concentration elutes DM18 large pore resin absorption columns, collects 84% ethanol eluate of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition can be adopted
The conventional method of galenic pharmacy prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition and chemical drugs
Or Chinese medicine composition prevents and treats neurodermatitis medicine.
It is evident in efficacy that pharmaceutical composition prevents and treats neurodermatitis.
Specific embodiment
Embodiment 1：Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：Poly- algae 525g purple fiber crops 517g rings wood
The black gland loosestrife 545g of pineapple alkanol 26g acetovanillone 23g；
Preparation method：
（1）Poly- algae, purple fiber crops, cycloartanol, acetovanillone, black gland loosestrife are taken by bulk drug proportioning, is mixed, with weight hundred
Divide 29% ethanol of specific concentration as solvent, 32.5 DEG C of temperature extractions take, and extraction time is 10 times, and each extraction time is 20 hours, often
33 times for bulk drug gross weight of secondary solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid are first washed with water, then use weight percent concentration by LKS02 large pore resin absorption columns
47.5% ethanol solution elutes LKS02 large pore resin absorption columns, collects 47.5% ethanol eluate of weight percent concentration, reclaims second
Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 65% ethanol of weight percent concentration as solvent, heating and refluxing extraction 7 times, is carried every time
The time is taken for 0.3 hour, 20 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, liquid is first washed with water, then uses weight by DM18 large pore resin absorption columns
84% ethanol solution of percent concentration elutes DM18 large pore resin absorption columns, collects 84% ethanol eluate of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：Poly- algae 520g purple fiber crops 520g rings wood
The black gland loosestrife 540g of pineapple alkanol 24g acetovanillone 26g；
Preparation method：
（1）Poly- algae, purple fiber crops, cycloartanol, acetovanillone, black gland loosestrife are taken by bulk drug proportioning, is mixed, with weight hundred
Divide 29% ethanol of specific concentration as solvent, 32.5 DEG C of temperature extractions take, and extraction time is 10 times, and each extraction time is 20 hours, often
33 times for bulk drug gross weight of secondary solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid are first washed with water, then use weight percent concentration by LKS02 large pore resin absorption columns
47.5% ethanol solution elutes LKS02 large pore resin absorption columns, collects 47.5% ethanol eluate of weight percent concentration, reclaims second
Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 65% ethanol of weight percent concentration as solvent, heating and refluxing extraction 7 times, is carried every time
The time is taken for 0.3 hour, 20 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, liquid is first washed with water, then uses weight by DM18 large pore resin absorption columns
84% ethanol solution of percent concentration elutes DM18 large pore resin absorption columns, collects 84% ethanol eluate of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：Poly- algae 530g purple fiber crops 512g rings wood
The black gland loosestrife 550g of pineapple alkanol 28g acetovanillone 20g；
Preparation method：
（1）Poly- algae, purple fiber crops, cycloartanol, acetovanillone, black gland loosestrife are taken by bulk drug proportioning, is mixed, with weight hundred
Divide 29% ethanol of specific concentration as solvent, 32.5 DEG C of temperature extractions take, and extraction time is 10 times, and each extraction time is 20 hours, often
33 times for bulk drug gross weight of secondary solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid are first washed with water, then use weight percent concentration by LKS02 large pore resin absorption columns
47.5% ethanol solution elutes LKS02 large pore resin absorption columns, collects 47.5% ethanol eluate of weight percent concentration, reclaims second
Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 65% ethanol of weight percent concentration as solvent, heating and refluxing extraction 7 times, is carried every time
The time is taken for 0.3 hour, 20 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, liquid is first washed with water, then uses weight by DM18 large pore resin absorption columns
84% ethanol solution of percent concentration elutes DM18 large pore resin absorption columns, collects 84% ethanol eluate of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
1 pharmaceutical composition 130g of Example, adds starch 220g, mixes, and granulation is dried, plus microcrystalline cellulose 120g, stearic
Sour magnesium 10g, mixes, is pressed into 1800, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
2 pharmaceutical composition 310g of Example, adds starch 420g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid
Magnesium, mixes, encapsulated 2100, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 205g water-baths and boil molten, add 3 pharmaceutical composition 14g of embodiment, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 3 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip are 2.8cm away from liquid level, and drop speed is per dividing 57 drops as optimum condition, to blot the cold of dripping pill surface with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：Prevent and treat the pharmaceutical composition of neurodermatitis
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：
Black 360 weight portion of gland loosestrife of numb 580 weight portion acetovanillone, 25 weight portion of purple.
Embodiment 8：Prevent and treat the pharmaceutical composition of neurodermatitis
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：
Black 350 weight portion of gland loosestrife of 40 weight portion acetovanillone of cycloartanol, 12 weight portion.
Embodiment 9：Prevent and treat the pharmaceutical composition of neurodermatitis
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：
Black 650 weight portion of gland loosestrife of 70 weight portion acetovanillone of cycloartanol, 50 weight portion.
Experimental example 1：Prevent and treat the experimental study of neurodermatitis
1. clinical data
In 18, man 8, female 10；Age 13-48 year；Course of disease 1-3 person 6, more than 3 years persons 12.All patients are accorded with
Close neurodermatitis diagnostic criteria.And have interruption oral anti-allergy medicine and externally applied drug history.When medical, patient's four limbs, thoracic dorsal, neck
Napex skin plays rash, pachyderma, coarse drying, itching or flush, knot corridor, ooze out, the infringement of the different skin such as pain.
2. treatment method
2.1 prescriptions of traditional Chinese medicine
Pharmaceutical composition：1 pharmaceutical composition of embodiment（Lot number 20110305）.
2.2 fumigating method
With the production of Chinese Yancheng Economic Developing medical supplies factory with type automatic fumigation Medicated bath device.Chlorohexidene first with l% is molten
Liquid is cleaned or spray disinfectant affected part, and pharmaceutical composition is put by (to there is the possible patient's fumigation apparatus of infection special, periodically sterilizing)
In people's digester plus suitable quantity of water, switch on power, grasp fumigation temperature and time, generally preferably use 43 DEG C -45 DEG C, 20-30min
Temperature can be reduced by 1 DEG C -2 DEG C by combination, body heat person, and heat-resisting individuality is available 45 DEG C -47 DEG C, and temperature can be automatically adjusted, every time
30min, it is daily 1-2 time.During treatment, head is fully exposed to outer.Due to excessive sweating, suitably should drink water in the treatment.It is used in conjunction 10
It is the l courses for the treatment of, and effectively but not healing person can continual cure.
3. treatment results
In 18, cure (pachyderma, coarse, knot silly, itching, ooze out, the clinical symptoms such as pain are wholly absent, follow-up after l
Do not recur) 14, take a turn for the better (above-mentioned clinical symptoms disappear, and after l, during follow-up skin, phlegm is itched, but papule does not occur) 4；1
The individual course for the treatment of cures 8, and 2 courses for the treatment of cure 4, and 3 courses for the treatment of cure 2.
Claims (8)
1. a kind of pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that make the composition of the bulk drug of the pharmaceutical composition
With weight portion it is：
Poly- algae 520-530 weight portions purple fiber crops 512-520 weight portion cycloartanol 24-28 weight portion acetovanillone 20-26
The black gland loosestrife 540-550 weight portions of weight portion.
2. a kind of pharmaceutical composition for preventing and treating neurodermatitis according to claim 1, it is characterised in that make the medicine group
The composition and weight portion of the bulk drug of compound be：
The black gland of 525 weight portion of the poly- algae numb 517 weight portion cycloartanol of purple, 26 weight portion acetovanillone, 23 weight portion is precious
545 weight portion of pearl dish.
3. a kind of pharmaceutical composition for preventing and treating neurodermatitis according to claim 1, it is characterised in that pharmaceutical composition can
Piece agent or capsule or dripping pill are prepared with the conventional method using galenic pharmacy.
4. a kind of pharmaceutical composition for preventing and treating neurodermatitis according to claim 1, it is characterised in that pharmaceutical composition with
What chemical drugs or Chinese medicine were constituted prevents and treats neurodermatitis medicine.
5. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Poly- algae 520-530 weight portions purple fiber crops 512-520 weight portion cycloartanols
The black gland loosestrife 540-550 weight portions of 24-28 weight portion acetovanillone 20-26 weight portions；
Preparation method：
（1）Poly- algae, purple fiber crops, cycloartanol, acetovanillone, black gland loosestrife are taken by bulk drug proportioning, is mixed, with weight hundred
Divide 29% ethanol of specific concentration as solvent, 32.5 DEG C of temperature extractions take, and extraction time is 10 times, and each extraction time is 20 hours, often
33 times for bulk drug gross weight of secondary solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid are first washed with water, then use weight percent concentration by LKS02 large pore resin absorption columns
47.5% ethanol solution elutes LKS02 large pore resin absorption columns, collects 47.5% ethanol eluate of weight percent concentration, reclaims second
Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 65% ethanol of weight percent concentration as solvent, heating and refluxing extraction 7 times, is carried every time
The time is taken for 0.3 hour, 20 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, liquid is first washed with water, then uses weight by DM18 large pore resin absorption columns
84% ethanol solution of percent concentration elutes DM18 large pore resin absorption columns, collects 84% ethanol eluate of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis according to claim 5, it is characterised in that press
It is prepared by following steps：
The composition and weight portion of bulk drug be：Purple numb 517 weight portion cycloartanol, 26 weight portion of 525 weight portion of poly- algae
Black 545 weight portion of gland loosestrife of 23 weight portion of acetovanillone；
Preparation method：
（1）Poly- algae, purple fiber crops, cycloartanol, acetovanillone, black gland loosestrife are taken by bulk drug proportioning, is mixed, with weight hundred
Divide 29% ethanol of specific concentration as solvent, 32.5 DEG C of temperature extractions take, and extraction time is 10 times, and each extraction time is 20 hours, often
33 times for bulk drug gross weight of secondary solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid are first washed with water, then use weight percent concentration by LKS02 large pore resin absorption columns
47.5% ethanol solution elutes LKS02 large pore resin absorption columns, collects 47.5% ethanol eluate of weight percent concentration, reclaims second
Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 65% ethanol of weight percent concentration as solvent, heating and refluxing extraction 7 times, is carried every time
The time is taken for 0.3 hour, 20 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned
Ethanol is received, relative density 1.16 is concentrated into, is filtered, liquid is first washed with water, then uses weight by DM18 large pore resin absorption columns
84% ethanol solution of percent concentration elutes DM18 large pore resin absorption columns, collects 84% ethanol eluate of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis according to claim 5, it is characterised in that medicine
Compositions can adopt the conventional method of galenic pharmacy to prepare piece agent or capsule or dripping pill.
8. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis according to claim 5, it is characterised in that medicine
Compositions prevent and treat neurodermatitis medicine with chemical drugs or Chinese medicine composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611133235.3A CN106539838A (en) | 2016-12-10 | 2016-12-10 | Prevent and treat the pharmaceutical composition of neurodermatitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611133235.3A CN106539838A (en) | 2016-12-10 | 2016-12-10 | Prevent and treat the pharmaceutical composition of neurodermatitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106539838A true CN106539838A (en) | 2017-03-29 |
Family
ID=58397120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611133235.3A Withdrawn CN106539838A (en) | 2016-12-10 | 2016-12-10 | Prevent and treat the pharmaceutical composition of neurodermatitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106539838A (en) |
-
2016
- 2016-12-10 CN CN201611133235.3A patent/CN106539838A/en not_active Withdrawn
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Application publication date: 20170329 |