CN106619979A - Pharmaceutical composition for preventing and treating neurodermatitis - Google Patents
Pharmaceutical composition for preventing and treating neurodermatitis Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for preventing and treating neurodermatitis and a preparation method thereof. The pharmaceutical composition is prepared from root of Gomphandra hainanensis, herb of oblongleaf heterostemma, herb of Mazus stachydifolius, capillarisin, nepitrin, and cucurbitacin L; the pharmaceutical composition may be prepared into various forms of drug according to conventional pharmaceutical processes to significantly prevent and treat neurodermatitis.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for preventing and treating neurodermatitis and its preparation
Method.
Background technology
Neurodermatitis, the traditional Chinese medical science is referred to as neurodermatitis, often occurs in neck, patella ulnaris joint, tail energy portion etc..Show as play
Itch, skin of scratching for a long time can thicken to form papule block, and lichenification then, area has pigmentation for 1 to several centimeters, often there is bran
Furfur can affect sleep, not heal in the course of disease slow constant year.This disease is divided into wind-heat phase, insufficiency of the spleen with overabundance of dampness phase, liver depression blood addiction phase by the traditional Chinese medical science, and one
As go to a doctor when after two phases it is in the majority.
The neurodermatitis cause of disease is not completely clear and definite, but fatigue, it is nervous and scratch, rub, it is Exposure to Sunlight, many
Sweat, drink or the physical stimulating factor of mechanicalness can inspire the disease, aggravate disease.The course of disease delay, is easy to recurrence.It is logical
Crossing herbal fumigation quickly can fully expand human peripheral capilary and rete vasculosum, human bloodstream state be improved quickly, especially
It is the microcirculating state for being obviously improved human body.Under smoked swallow dipping state, dissipate because of heat energy, drug microparticles easily pass through skin
Directly absorb, into passages through which vital energy circulates blood network, pleased cloth whole body and play the therapeutic action of medicine.
Black bone is galloped along on horseback:This product is that Icacinaceae must stamen fogfruit crin wood Gomphandra tetrandra(Wall.et
Roxb.)Sleum [ Lasian theratetrandra Wall.et Roxb.;Gomphandra hainanensis Merr. ]
Root.Whole year can excavate, and clean, and section is dried.【Nature and flavor】It is bitter;It is flat.【Indication】Clearing away damp-heat;Relieving heat toxin.Master is damp and hot
Vomit and diarrhoea;Carbuncle sore tumefacting virus.【Former phytomorph】Crin wood shrub or dungarunga, high 2-10m.Bark grey, spray green, then
Raw branch is become without hair later by pubescence.Leaf alternate, the long 0.5-1.5cm of petiole, just by pubescence;Leaf papery, narrow lanceolar, length
Oval or oblong, long 6-15cm, wide 2-6cm, tip is tapering, base portion wedge shape, full edge, two sides without hair or during children below quilt
Faint yellow pubescence, above it is dark green, below slightly weaker, middle arteries overleaf significant protuberance, lateral vein about 6-8 pair, net vein is not obvious.Male and female
Different strain, cyme and leaf opposite, armpit life sometimes, long 2-4cm is close by yellow-white pubescence, has common peduncle, the long 0.2- of bennet
0.5cm;Male flower yellow-white or white green, 5 numbers are about 5mm, and corolla is bell, long 3-4mm, the nearly triangle of petal sliver, and length is about
The 1/3 of corolla, inward curl, outside is without hair;Stamen 4-5, filigree is longer than corolla;Female flower yellow-white, is about 5mm, calyx micro- 5
Split, it is long less than 5mm;Corolla is bell, is about 0.5mm, and petal sliver Yangtze River Delta shape is curved in tip;Obsolete stamen in female flower
Isometric with ovary, ovary is cylindric, and without hair or sometimes by hair, column cap is little, 5 split it is slightly downward in ovary.Drupe is oval, is about
1.2-2.5cm, footpath 0.5-1.2cm, white when ripe, berry shape has obvious vertical rib after doing, and carpopodium is slightly by pubescence.Flower, fruiting period
It is annual.Record in dictionary of medicinal plant.
Oblongleaf Heterostemma:This product is dicotyledon medicine Asclepiadaceae Winged Heterostemma platymiscium Oblongleaf Heterostemma Hetrostemma
The complete stool of oblongifolium Cost..Autumn harvests, and dries.【Nature and flavor】It is slight bitter, sweet;It is flat.【Return through】Liver Channel.【Function master
Control】Lactagogue.Qi and blood stasis after main product;Agalactia.【Former phytomorph】Weak winding liana.Complete stool has milk, and stem is by 2 row
Pubescence.Leaf opposite;The long 2-4cm of petiole;Blade Long Circle, dilute ovate Long Circle, long 7.5-11cm, wide 3.5-4.5cm, tip is sharp
Point, basal circular;Per side 5-7 bars, arc rises lateral vein.Umbrella shape shape cyme armpit is given birth to, and long 2-3cm is blossomed 4-5;Calyx 5
Drastic crack, inner face base portion has body of gland about 10;Corolla outside light green, inner face yellow, spoke shape, diameter 1-1.5cm;Corolla splits levies 5,
Cover to the right;Paracorolla five-pointed star aristiform, the every room 1 of massula, square circular, uprightly.Follicle radish fruit wire lanceolar, is up to
12cm, diameter about 1cm, it is tapering to tip.Seed is up to 2cm, wide about 3mm, white thin,tough silk matter kind hair of the seed tool up to 3cm.Flower
Month phase 8-10, the fruiting period 9-12 month.Record in dictionary of medicinal plant.
Betonyleaf mazus herb:This product is Scrophulariaceae Mazus plant betonyleaf mazus herb Mazus stachydifolius
(Turcz.)Maxim. herb.Harvest when yielding positive results, dry.【Nature and flavor】Taste micro-pungent;It is cool in nature.【Indication】Heat-clearing solution
Poison;Cool blood dissipates the stasis of blood.Blood under main constipation;Sore furuncle poison;Venomous snake bite;Traumatic injury.【Original shape state】Perennial herb, high 10-
50cm.Sturdy, complete stool is by white long pubescence.Root-like stock is short;Stem is upright, dilute rising, cylinder, not branch or base portion branch, always
When base portion lignifying.Basal leaf cochlear, there is short handle, often early withered;Stem leaf opposite, the normal alternate on top, stockless;Blade length is oval
Shape is to ovum shape lanceolar;Papery, long 2-7cm is big with the amount in the middle part of stem, edge tool sawtooth.Raceme basidixed, long 2-
20cm, spends sparse;Bract triangle;Calyx funnel-form, long 0.5-1cm is longer than bennet, and calyx tooth is slightly longer than cylinder portion, and tip length is sharp
Point;Corolla purple is with long 1.5-2cm;Tube is closely isometric with lip, and upper lip is short, and 2 split, sliver long-narrow triangular mesh, end point, under
Lip is roomy, carries out, and 3 split, and middle sliver is little compared with side sliver, and subcircular is slightly projected, have two the through throat of gauffer of raw glandular hairs;
4 pieces of stamen, the last two;Ovary top is by long bristle.The flat ovoid of capsule, long 2-4mm.The month at florescence 4-6, the fruiting period 7-9 month.Record in
Dictionary of medicinal plant.
Capillarisin(Capillarisin):CAS 56365-38-9, molecular formula C16H12O7, molecular weight 316.26.
【Pharmacological action】Cholagogic.【Ingredient origin】Feverfew Artemisia capillaris aerial part.
Nepeta glycosides(Nepetin-7-glucoside):CAS 569-90-4, molecular formula C22H22O12, molecular weight
478.40.【Ingredient origin】Common Sage Herb Salvia plebeian..
Cucurbitacin L( Cucurbitacin L):CAS 1110-02-7, molecular formula C30H44O7, molecular weight 516.67.【It is raw
Thing activity】Antitumor (animal Ehrlich ascites carcinoma in vivo, increase in life span 38%~42%), cell toxicant(KB in
Vitro, ED50=0.01~0.1ug/ml, HeLa in vitro, ED50=0.1ug/ml).【Ingredient origin】Cowbind
Bryonia alba, squirting cucumber Ecballium elaterium, without tendril watermelon Citrullus ecirrhosus, coloquintida
Citrullus colocynthis。
The chemical constitution of 3 bulk drugs:
Nepeta glycosides(Nepetin-7-glucoside)
Capillarisin(Capillarisin)Cucurbitacin L( Cucurbitacin L).
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of drug regimen for effectively preventing and treating neurodermatitis
Thing and preparation method thereof.
The present invention adopts the following technical scheme that realization:
The composition and weight portion for making the bulk drug of the pharmaceutical composition for preventing and treating neurodermatitis be:
Black bone is galloped along on horseback 800-810 weight portion Oblongleaf Heterostemma 750-758 weight portion betonyleaf mazus herb 740-750 weight portion oriental wormwood colors
Former ketone 65-70 weight portions Nepeta glycosides 30-40 weight portion cucurbitacin L20-24 weight portions.
The pharmaceutical composition for preventing and treating neurodermatitis is preferably used in, is made up of the bulk drug of following weight portion:
Black bone is galloped along on horseback the weight portion of 805 weight portion Oblongleaf Heterostemma, 754 weight portion betonyleaf mazus herb, 745 weight portion capillarisin 68
The weight portion cucurbitacin L22 weight portions of Nepeta glycosides 35.
A kind of pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition can adopt the normal of galenic pharmacy
Rule method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine
Prevent and treat neurodermatitis medicine.
A kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that prepare as follows:
The composition and weight portion of bulk drug be:Black bone is galloped along on horseback 800-810 weight portion Oblongleaf Heterostemma 750-758 weight portion bullet knives
Dish 740-750 weight portion capillarisin 65-70 weight portion Nepeta glycosides 30-40 weight portion cucurbitacins L20-24 weights
Amount part;
Preparation method:
(1)By bulk drug proportioning take Oblongleaf Heterostemma, betonyleaf mazus herb, black bone gallop along on horseback, capillarisin, Nepeta glycosides, cucurbitacin L,
Mix, with the ethanol of weight percent concentration 37% as solvent, take in 30.5 DEG C of temperature extractions, extraction time is 9 times, is extracted every time
Time is 6 hours, and each solvent load is 13 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extract A, and extract A is returned
Ethanol is received, relative density 1.10 is concentrated into, is filtered, liquid is first washed with water by LKS02 large pore resin absorption columns, then with again
Amount percent concentration 21% ethanol solution wash-out LKS02 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 21%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 56% as solvent, heating and refluxing extraction 12 times, carries every time
The time is taken for 0.9 hour, each solvent load is 17 times of dregs of a decoction A weight, filters, obtain dregs of a decoction B and extract B, extract B is returned
Ethanol is received, relative density 1.05 is concentrated into, is filtered, liquid is first washed with water by XDA-7 large pore resin absorption columns, then with again
Amount percent concentration 79% ethanol solution wash-out XDA-7 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 79%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that make as follows
It is standby:
The composition and weight portion of bulk drug be:Black bone is galloped along on horseback the weight of 805 weight portion Oblongleaf Heterostemma, 754 weight portion betonyleaf mazus herb 745
The weight portion cucurbitacin L22 weight portions of 68 weight portion Nepeta glycosides of amount part capillarisin 35;
Preparation method:
(1)By bulk drug proportioning take Oblongleaf Heterostemma, betonyleaf mazus herb, black bone gallop along on horseback, capillarisin, Nepeta glycosides, cucurbitacin L,
Mix, with the ethanol of weight percent concentration 37% as solvent, take in 30.5 DEG C of temperature extractions, extraction time is 9 times, is extracted every time
Time is 6 hours, and each solvent load is 13 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extract A, and extract A is returned
Ethanol is received, relative density 1.10 is concentrated into, is filtered, liquid is first washed with water by LKS02 large pore resin absorption columns, then with again
Amount percent concentration 21% ethanol solution wash-out LKS02 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 21%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 56% as solvent, heating and refluxing extraction 12 times, carries every time
The time is taken for 0.9 hour, each solvent load is 17 times of dregs of a decoction A weight, filters, obtain dregs of a decoction B and extract B, extract B is returned
Ethanol is received, relative density 1.05 is concentrated into, is filtered, liquid is first washed with water by XDA-7 large pore resin absorption columns, then with again
Amount percent concentration 79% ethanol solution wash-out XDA-7 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 79%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition can be adopted
The conventional method of galenic pharmacy prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition and chemical drugs
Or Chinese medicine composition prevents and treats neurodermatitis medicine.
It is notable that pharmaceutical composition prevents and treats neurodermatitis effect.
Specific embodiment
Embodiment 1:Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be:Black bone is galloped along on horseback 805g Oblongleaf Heterostemmas
754g betonyleaf mazus herb 745g capillarisin 68g Nepeta glycosides 35g cucurbitacin L22g;
Preparation method:
(1)By bulk drug proportioning take Oblongleaf Heterostemma, betonyleaf mazus herb, black bone gallop along on horseback, capillarisin, Nepeta glycosides, cucurbitacin L,
Mix, with the ethanol of weight percent concentration 37% as solvent, take in 30.5 DEG C of temperature extractions, extraction time is 9 times, is extracted every time
Time is 6 hours, and each solvent load is 13 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extract A, and extract A is returned
Ethanol is received, relative density 1.10 is concentrated into, is filtered, liquid is first washed with water by LKS02 large pore resin absorption columns, then with again
Amount percent concentration 21% ethanol solution wash-out LKS02 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 21%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 56% as solvent, heating and refluxing extraction 12 times, carries every time
The time is taken for 0.9 hour, each solvent load is 17 times of dregs of a decoction A weight, filters, obtain dregs of a decoction B and extract B, extract B is returned
Ethanol is received, relative density 1.05 is concentrated into, is filtered, liquid is first washed with water by XDA-7 large pore resin absorption columns, then with again
Amount percent concentration 79% ethanol solution wash-out XDA-7 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 79%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2:Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be:Black bone is galloped along on horseback 800g Oblongleaf Heterostemmas
758g betonyleaf mazus herb 740g capillarisin 70g Nepeta glycosides 30g cucurbitacin L24g;
Preparation method:
(1)By bulk drug proportioning take Oblongleaf Heterostemma, betonyleaf mazus herb, black bone gallop along on horseback, capillarisin, Nepeta glycosides, cucurbitacin L,
Mix, with the ethanol of weight percent concentration 37% as solvent, take in 30.5 DEG C of temperature extractions, extraction time is 9 times, is extracted every time
Time is 6 hours, and each solvent load is 13 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extract A, and extract A is returned
Ethanol is received, relative density 1.10 is concentrated into, is filtered, liquid is first washed with water by LKS02 large pore resin absorption columns, then with again
Amount percent concentration 21% ethanol solution wash-out LKS02 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 21%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 56% as solvent, heating and refluxing extraction 12 times, carries every time
The time is taken for 0.9 hour, each solvent load is 17 times of dregs of a decoction A weight, filters, obtain dregs of a decoction B and extract B, extract B is returned
Ethanol is received, relative density 1.05 is concentrated into, is filtered, liquid is first washed with water by XDA-7 large pore resin absorption columns, then with again
Amount percent concentration 79% ethanol solution wash-out XDA-7 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 79%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3:Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be:Black bone is galloped along on horseback 810g Oblongleaf Heterostemmas
750g betonyleaf mazus herb 750g capillarisin 65g Nepeta glycosides 40g cucurbitacin L20g;
Preparation method:
(1)By bulk drug proportioning take Oblongleaf Heterostemma, betonyleaf mazus herb, black bone gallop along on horseback, capillarisin, Nepeta glycosides, cucurbitacin L,
Mix, with the ethanol of weight percent concentration 37% as solvent, take in 30.5 DEG C of temperature extractions, extraction time is 9 times, is extracted every time
Time is 6 hours, and each solvent load is 13 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extract A, and extract A is returned
Ethanol is received, relative density 1.10 is concentrated into, is filtered, liquid is first washed with water by LKS02 large pore resin absorption columns, then with again
Amount percent concentration 21% ethanol solution wash-out LKS02 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 21%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 56% as solvent, heating and refluxing extraction 12 times, carries every time
The time is taken for 0.9 hour, each solvent load is 17 times of dregs of a decoction A weight, filters, obtain dregs of a decoction B and extract B, extract B is returned
Ethanol is received, relative density 1.05 is concentrated into, is filtered, liquid is first washed with water by XDA-7 large pore resin absorption columns, then with again
Amount percent concentration 79% ethanol solution wash-out XDA-7 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 79%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4:The preparation of tablet
The pharmaceutical composition 350g of Example 1, adds starch 450g, mixes, and granulation is dried, plus microcrystalline cellulose 60g, stearic
Sour magnesium 8g, mixes, and is pressed into 2500, obtains final product medicinal composition tablets.
Embodiment 5:The preparation of capsule
The pharmaceutical composition 180g of Example 2, adds starch 180g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid
Magnesium, mixes, and encapsulated 900, obtains final product medicament composition capsule.
Embodiment 6:The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 250g water-baths and boil molten, add the pharmaceutical composition 10g of embodiment 3, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube(4*80cm)In, chilling temperature is 2 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.3cm away from liquid level, and drop speed, as optimum condition, with cotton the cold of dripping pill surface is blotted with per point 40 drops
Solidifying agent, obtains final product medicament composition dropping pills.
Experimental example 1:Prevent and treat the experimental study of neurodermatitis
1. clinical data
In 15, man 7, female 8;Age 13-48 year;Course of disease 1-3 person 7, more than 3 years persons 8.All patients meet
Neurodermatitis diagnostic criteria.And have an interruption oral anti-allergy medicine and externally applied drug history.When medical, patient's four limbs, thoracic dorsal, neck
Portion's skin plays rash, pachyderma, coarse drying, itching or flush, knot corridor, ooze out, the infringement of the different skin such as pain.
2. treatment method
2.1 prescriptions of traditional Chinese medicine
Pharmaceutical composition:The pharmaceutical composition of embodiment 1(Lot number 20110305).
2.2 fumigating method
With the production of Chinese Yancheng Economic Developing medical supplies factory with type automatic fumigation Medicated bath device.Chlorohexidene first with l% is molten
Liquid is cleaned or spray disinfectant affected part, and (to there is the possible patient's fumigation apparatus of infection special, periodically sterilization) puts pharmaceutical composition
In people's digester plus suitable quantity of water, switch on power, grasp fumigation temperature and time, generally preferably use 43 DEG C -45 DEG C, 20-30min
Temperature can be reduced by 1 DEG C -2 DEG C by combination, body heat person, and heat-resisting individuality is available 45 DEG C -47 DEG C, and temperature can be automatically adjusted, every time
30min, it is daily 1-2 time.Head is fully exposed to outer during treatment.Due to excessive sweating, should suitably drink water in the treatment.It is used in conjunction 10
It is the l courses for the treatment of, and effectively but not healing person can continual cure.
3. treatment results
In 15, cure (pachyderma, coarse, knot silly, itching, ooze out, the clinical symptoms such as pain are wholly absent, follow-up after l
Do not recur) 14, take a turn for the better (above-mentioned clinical symptoms disappear, after l during follow-up skin and phlegm is itched, but there is not papule) 1;1
The individual course for the treatment of cures 9, and 2 courses for the treatment of cure 5, and 3 courses for the treatment of cure 1.
Claims (8)
1. a kind of pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that make the composition of the bulk drug of the pharmaceutical composition
It is with weight portion:
Black bone is galloped along on horseback 800-810 weight portion Oblongleaf Heterostemma 750-758 weight portion betonyleaf mazus herb 740-750 weight portion oriental wormwood colors
Former ketone 65-70 weight portions Nepeta glycosides 30-40 weight portion cucurbitacin L20-24 weight portions.
2. a kind of pharmaceutical composition for preventing and treating neurodermatitis according to claim 1, it is characterised in that make the medicine group
The composition and weight portion of the bulk drug of compound be:
Black bone is galloped along on horseback the weight portion of 805 weight portion Oblongleaf Heterostemma, 754 weight portion betonyleaf mazus herb, 745 weight portion capillarisin 68
The weight portion cucurbitacin L22 weight portions of Nepeta glycosides 35.
3. a kind of pharmaceutical composition for preventing and treating neurodermatitis according to claim 1, it is characterised in that pharmaceutical composition can
To prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for preventing and treating neurodermatitis according to claim 1, it is characterised in that pharmaceutical composition with
What chemical drugs or Chinese medicine were constituted prevents and treats neurodermatitis medicine.
5. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that prepare as follows:
Black bone is galloped along on horseback 800-810 weight portion Oblongleaf Heterostemma 750-758 weight portion betonyleaf mazus herb 740-750 weight portion oriental wormwood colors
Former ketone 65-70 weight portions Nepeta glycosides 30-40 weight portion cucurbitacin L20-24 weight portions;
Preparation method:
(1)By bulk drug proportioning take Oblongleaf Heterostemma, betonyleaf mazus herb, black bone gallop along on horseback, capillarisin, Nepeta glycosides, cucurbitacin L,
Mix, with the ethanol of weight percent concentration 37% as solvent, take in 30.5 DEG C of temperature extractions, extraction time is 9 times, is extracted every time
Time is 6 hours, and each solvent load is 13 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extract A, and extract A is returned
Ethanol is received, relative density 1.10 is concentrated into, is filtered, liquid is first washed with water by LKS02 large pore resin absorption columns, then with again
Amount percent concentration 21% ethanol solution wash-out LKS02 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 21%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 56% as solvent, heating and refluxing extraction 12 times, carries every time
The time is taken for 0.9 hour, each solvent load is 17 times of dregs of a decoction A weight, filters, obtain dregs of a decoction B and extract B, extract B is returned
Ethanol is received, relative density 1.05 is concentrated into, is filtered, liquid is first washed with water by XDA-7 large pore resin absorption columns, then with again
Amount percent concentration 79% ethanol solution wash-out XDA-7 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 79%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis according to claim 5, it is characterised in that press
It is prepared by following steps:
Black bone is galloped along on horseback the weight portion of 805 weight portion Oblongleaf Heterostemma, 754 weight portion betonyleaf mazus herb, 745 weight portion capillarisin 68
The weight portion cucurbitacin L22 weight portions of Nepeta glycosides 35;
Preparation method:
(1)By bulk drug proportioning take Oblongleaf Heterostemma, betonyleaf mazus herb, black bone gallop along on horseback, capillarisin, Nepeta glycosides, cucurbitacin L,
Mix, with the ethanol of weight percent concentration 37% as solvent, take in 30.5 DEG C of temperature extractions, extraction time is 9 times, is extracted every time
Time is 6 hours, and each solvent load is 13 times of bulk drug gross weight, filters, and obtains dregs of a decoction A and extract A, and extract A is returned
Ethanol is received, relative density 1.10 is concentrated into, is filtered, liquid is first washed with water by LKS02 large pore resin absorption columns, then with again
Amount percent concentration 21% ethanol solution wash-out LKS02 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 21%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract A;
(2)Take step(1)Dregs of a decoction A, with the ethanol of weight percent concentration 56% as solvent, heating and refluxing extraction 12 times, carries every time
The time is taken for 0.9 hour, each solvent load is 17 times of dregs of a decoction A weight, filters, obtain dregs of a decoction B and extract B, extract B is returned
Ethanol is received, relative density 1.05 is concentrated into, is filtered, liquid is first washed with water by XDA-7 large pore resin absorption columns, then with again
Amount percent concentration 79% ethanol solution wash-out XDA-7 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 79%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B;
(3)Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis according to claim 5, it is characterised in that medicine
Compositions can adopt the conventional method of galenic pharmacy to prepare piece agent or capsule or dripping pill.
8. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis according to claim 5, it is characterised in that medicine
Compositions prevent and treat neurodermatitis medicine with chemical drugs or Chinese medicine composition.
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2016
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