CN106511924B - For hair growth, the externally-applied medicinal composition for promoting hair tonic and preparation method thereof - Google Patents
For hair growth, the externally-applied medicinal composition for promoting hair tonic and preparation method thereof Download PDFInfo
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- CN106511924B CN106511924B CN201610975084.XA CN201610975084A CN106511924B CN 106511924 B CN106511924 B CN 106511924B CN 201610975084 A CN201610975084 A CN 201610975084A CN 106511924 B CN106511924 B CN 106511924B
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- A—HUMAN NECESSITIES
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Abstract
The invention discloses for hair growth, the externally-applied medicinal composition for promoting hair tonic and preparation method thereof, belong to the field of Chinese medicines.Externally-applied medicinal composition of the invention is by including that the bulk pharmaceutical chemicals component of following parts by weight is made: 60-120 parts of eclipta, 30-60 parts of the fleece-flower root, 50-100 parts of mulberry leaf, 30-60 parts of cacumen biotae, 50-100 parts of Radix Salviae Miltiorrhizae, 20-110 parts of cedar wood alcohol, 5-10 parts of pumpkin seed oil.Or it can also increase the bulk pharmaceutical chemicals component of following parts by weight: 30-50 parts of caulis trachelospermi, 25-55 parts of ginger, 10-20 parts of lilac daphne.The present invention uses traditional Chinese medicine extraction component, and the metabolic function of scalp and hair root nutrients can not only be promoted to absorb, effective hair growth, and can be with activating microcirculation and removing stasis medicinal, hair follicle stimulating growth to reach the effect of promoting hair restoration.
Description
Technical field
It is the present invention relates to a kind of Chinese medicine composition, in particular to a kind of for hair growth, the external drug of promotion hair tonic
Composition and preparation method thereof belongs to technical field of Chinese medicine.
Background technique
Record in relation to alopecia sees "Nei Jing" earliest, and referred to as hair is pulled out, dealt with, sending out pendant.With social development, work section
It plays, the variation of the external environments such as life style, alopecia is not only to be caused by void, even more due to the increase of stress and drink
A kind of hair loss disorder of unbalance caused simulataneous insufficiency and excessive of food.Alopecia is modern clinic common disease, though it is not belonging to serious disease
Disease, but spirit, psychology and the image of people are influenced, alopecia also brings endless worry to people's lives.People are to cosmetology
Requirement be increasingly urgent to, modern medicine and traditional medicine also increasingly pay attention to the research to alopecia.
Alopecia (alopecia) disease is belonged to the sick range such as Chinese medicine " alopecia areata " " alopecia areata ", is clinical common disease, is subtracted with hair
It is characterized less.Alopecia is a kind of multifactor lysis for participating in leading to morbidity, and infection, hormone, immune, heredity are all its morbidities
Important factor in order in the process, the inflammatory injury of hair follicle may be the immediate cause for leading to epilation.Alopecia disease
Including alopecia areata, androgenetic alopecia (also known as male pattern alopecia, alopecia seborrheica), alopecia due to chemotherapy, alopecia senilis, scar
The property types such as alopecia and psychogenic alopecia.Hair loss patient, which is frequently due to certain factors, causes hair to enter hair too early by growth period
Long resting stage, hair follicle and ball top atrophy occurs, is become thin hair from terminal hair and is caused.
Alopecia areata is mostly limitation patch shape baldness, and the small number of patients state of an illness is more serious, may occur in which whole alopecia or general alopecia.Pathogenic factor
It is unclear that thinking related with nervous and fatigue more.Mostly since kidney deficiency and liver, ailment said due to cold or exposure are taken advantage of a weak point or stagnation of QI due to depression of the liver, hair
It sends out caused by dystrophy.Alopecia areata often occurs suddenly, more no conscious symptons, in non-cicatrical, the inflammatory round or ellipse of limitation
Patch shape alopecia, not of uniform size, boundary is obvious.The hair development in patients with alopecia areata early stage in visible growth period is bad, perifollicolar
CD4 +T cell infiltration.Advanced stage visible hair follicle atrophy, hair and papilla become smaller, the new non-full-shape of setation, and intradermal is visible
Vasculitis and periangiitis, blood vessel reticular density are reduced.
Androgenetic alopecia has family history, is the hereditary alopecia disease of androgen-dependent.Account for about the 90% of all alopecias.
Generally believe that the disease is a kind of disease of multifactorial inheritance of Androgen-dependent in recent years.Androgenetic alopecia includes male pattern alopecia
And female alopecia, it is mainly shown as the gradual alopecia at the head area E Nie and top, androgen levels of hair loss patient and normal
People is close, the hair follicle of this patient is congenital to Androgen-sensitive, can be gathered in hair follicle due to 5- α protona and inhibit its generation
It apologizes for having done sth. wrong journey.Its cause of disease and pathogenesis are complicated, it is now recognized that the metabolic disorder of genetic predisposition and scalp hair follicles local androgen
It is to lead to this pathogenetic principal element.
Alopecia seborrheica is then more common in male person between twenty and fifty, often shows as from the beginning of forehead and two sides baldness, gradually symmetrically to head
Top extends, the very thin rareness of hair, conscious itch, and vigorous with scalp sebum secretion.Main pathological manifestations are resting stage
Hair follicle quantity increases, and the hair follicle quantity of growth terminal phase is reduced, and hair follicle is obviously miniaturized, and growth period shortens, and course of disease latter stage can have
Inflammation and fibrosis.Alopecia seborrheica is mostly asthenia in origin and asthenia in superficiality or simulataneous insufficiency and excessive disease, and long-term psychological unbalance, germ infection, diet lose
It adjusts, stress can induce or aggravate the state of an illness.
The product of hair growth is many and diverse on the market now, and western medicine baldness is mainly hormone regulator, hormone control
Agent has endocrine therapy agent and estrogen-mediated agent etc., but these drug prices are higher, and side effect is relatively large, is also easy to produce drug resistance
Property, be not suitable for patient and be used for a long time；The Chinese medicine hair growth disease time is very long, and slow effect also compare the effect of head hair follicle
It is limited, and have the possibility for aggravating lesions of liver and kidney；The also hair care product of some hair growths, but complex chemical composition, contain
There are the chemical products being harmful to the human body, side effect is larger, is not easy to be used for a long time, so the drug in lesion affected part can really be reached very
It is limited.
The present invention studies alopecia etiology and pathogenesis on the basis of diagnosis and treatment, each to treat to adjust qi and blood, detoxification and removing stasis
The alopecia disease of seed type, can not only boost metabolism function, promote hair root nutrients to absorb, and can be with activating microcirculation and removing stasis medicinal
It is grown with hair follicle stimulating.The present invention uses natural Chinese traditional medicines extract component, promotes hair restoration, and therapeutic effect is significant, and poison is secondary to be made
It is the specific drug of hair growth with small.
Summary of the invention
The purpose of the present invention is to provide can be used for hair growth, the externally-applied medicinal composition for promoting hair tonic and its preparation side
Method.
In order to achieve the above object, present invention employs following technological means:
Of the invention is a kind of for hair growth, the externally-applied medicinal composition of promotion hair tonic, by the original of following parts by weight
Material medicine is made: 60-120 parts of eclipta, 30-60 parts of the fleece-flower root, 50-100 parts of mulberry leaf, 30-60 parts of cacumen biotae, Radix Salviae Miltiorrhizae 50-100
Part, 20-110 parts of cedar wood alcohol and 5-10 parts of pumpkin seed oil.
In the present invention, it is preferred to, the externally-applied medicinal composition is made of the bulk pharmaceutical chemicals of following parts by weight: ink drought
80-100 parts of lotus, 40-50 parts of the fleece-flower root, 60-90 parts of mulberry leaf, 30-60 parts of cacumen biotae, 60-90 parts of Radix Salviae Miltiorrhizae, 40-90 parts of cedar wood alcohol
And 5-10 parts of pumpkin seed oil.
It is furthermore preferred that the externally-applied medicinal composition is made of the bulk pharmaceutical chemicals of following parts by weight: 90 parts of eclipta, what
45 parts of the tuber of multiflower knotweed, 75 parts of mulberry leaf, 45 parts of cacumen biotae, 75 parts of Radix Salviae Miltiorrhizae, 65 parts of cedar wood alcohol and 7 parts of pumpkin seed oil.
Another of the invention is for hair growth, the externally-applied medicinal composition of promotion hair tonic, by following parts by weight
Bulk pharmaceutical chemicals are made: 60-120 parts of eclipta, 30-60 parts of the fleece-flower root, 50-100 parts of mulberry leaf, 30-60 parts of cacumen biotae, Radix Salviae Miltiorrhizae 50-100
Part, 20-110 parts of cedar wood alcohol, 30-50 parts of caulis trachelospermi, 25-55 parts of ginger, 10-20 parts of lilac daphne and 5-10 parts of pumpkin seed oil.
In the present invention, it is preferred to, the externally-applied medicinal composition is made of the bulk pharmaceutical chemicals of following parts by weight: ink drought
80-100 parts of lotus, 40-50 parts of the fleece-flower root, 60-90 parts of mulberry leaf, 30-60 parts of cacumen biotae, 60-90 parts of Radix Salviae Miltiorrhizae, 40-90 parts of cedar wood alcohol,
35-45 parts of caulis trachelospermi, 30-45 parts of ginger, 10-15 parts of lilac daphne and 5-10 parts of pumpkin seed oil.
It is furthermore preferred that the externally-applied medicinal composition is made of the bulk pharmaceutical chemicals of following parts by weight: 90 parts of eclipta, what
45 parts of the tuber of multiflower knotweed, 75 parts of mulberry leaf, 45 parts of cacumen biotae, 75 parts of Radix Salviae Miltiorrhizae, 65 parts of cedar wood alcohol, 40 parts of caulis trachelospermi, 40 parts of ginger, 15 parts of lilac daphne
And 7 parts of pumpkin seed oil.
In Chinese medicine composition for hair growth of the invention, the function of each component is as follows:
Eclipta also known as Eclipta prostrata, Eclipta prostrata, Herba Ecliptae belong to the plant of composite family Eclipta prostrata.For the herb of compositae plant Eclipta prostrata, often
Nian Xia, Qiu Liangji extract herb, remove silt, drying or drying in the shade can be used as medicine.This product original name Eclipta prostrata, first recorded in Tang Materia Medica.
" figure is through book on Chinese herbal medicine " claims Eclipta prostrata.Li Shizhen (1518-1593 A.D.) is said: " non-irrigated lotus has two kinds: one seedlings like sheathed and grey thin person, is Eclipta prostrata；A kind of flower
Huang is purple and ties room such as lotus pod person, is that small lotus sticks up ... ".Ming Dynasty's Li Shizhen (1518-1593 A.D.) is write in Compendium of Material Medica: " eclipta, crow
Beard and hair, kidney-nourishing yin ".He thinks in Chinese herbal medicine, even if can make the optimal drug Eclipta prostrata of white hair blackening.Herb is medicinal, also
There is the effect of convergence, hemostasis, nourishing liver and kidney.Nature and flavor: it is sweet, sour, it trembles with fear.Channel tropism: return kidney, Liver Channel.Major function: nourishing liver and kidney, cool blood
Hemostasis.For tooth mobility, poliosis, dizziness and tinnitus, soreness and weakness of waist and knees, YinXuXueRe, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux collapses
Leak down blood, traumatic hemorrhage.
The fleece-flower root also known as spend more knotweed, purple black rattan, tuber fleeceflower stem etc..It is that the polygonaceae knotweed race fleece-flower root belongs to perennial winding liana plant
Object, root tuber is plump, oblong, dark brown.Raw mountain valley shrubbery, hillside hayashishita, ditch curb gap.Its root tuber is used as medicine, and can be calmed the nerves, be supported
Blood, active, removing toxic substances (preventing malaria), disappear carbuncle.Nature and flavor: bitter sweet is puckery, tepor.Channel tropism: enter liver and kidney channel.Major function: nourishing the blood and yin；Profit
Intestines defaecation；Preventing malaria；Wind-dispelling；Removing toxic substances.Main deficiency of blood Light-headedness；Palpitaition；Insomnia；The soreness and weakness of waist and knees of the deficiency of liver-yin and kidney-yin；Poliosis；Ear
Ring；Spermatorrhea；Dry constipation of intestines；Chronic malaria body void；Rubella itch；Sore carbuncle；Scrofula；Hemorrhoid.
Mulberry leaf are dried leaf also known as mulberry, thorn mulberry, mulberry fruit tree, yellow wood of moraceae plants mulberry etc..China, various regions, north and south are extensive
Mulberry tree is planted, mulberry yield is abundant, and gas is light, and mildly bitter flavor is puckery, medicinal it is generally acknowledged that the person's of adopting matter is good after frost.Nature and flavor: bitter；It is sweet；Property
It is cold.Channel tropism: enter lung, Liver Channel.Major function: dispelling wind and heat from the body；Clearing lung-heat；Improving eyesight.Main anemopyretic cold；Wind-warm syndrome is from the beginning of, fever and headache, sweat
Foul wind out, pectoralgia of coughing；Or dryness of the lung dry cough without phlegm；Dry throat and mouth；It is disturbed on wind-heat and liver-yang；Red eye, swell pain.For anemopyretic cold,
Lung-heat type cough, dizziness headache, red eyes and dim-sighted.
Cacumen biotae also known as Japan cypress, gold zone cypress are aiphyllium, and spray, Ye Jiguo can all be used as medicine, bitter, puckery, and property is micro-
It is cold, enter lung, liver, large intestine channel, there is the effect of cooling blood and hemostasis, black beard and hair, cough-relieving asthma.It is mainly used for hemorrhage caused by blood-heat bleeding
Disease, and have the effects of antibechic, eliminating the phlegm, decompression, Anti-hair loss.Kernel in its fruit then has the effect of mental-tranquilization, relax bowel and defecation.
Nature and flavor: it is bitter, puckery, it trembles with fear.Channel tropism: return lung, liver, the spleen channel.Effect: cooling blood and hemostasis, preventing phlegm from forming and stopping coughing, growing and blacking hair.
Radix Salviae Miltiorrhizae also known as red ginseng, wild ginseng, radix salviae miltiorrhizae, red root etc. are the dry root and rhizome of Lamiaceae plant Radix Salviae Miltiorrhizae.Spring, autumn
The excavation of two seasons removes silt, dry.National most area is all distributed.Nature and flavor: bitter, tepor.Channel tropism: enter the heart, Liver Channel.Function
Can be the major functions: promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness and restlessness, cool blood to disappear carbuncle.For chest impediment and cardialgia, stomach duct and abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, heat
Numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhea menostasis, sore swell and ache curative.
Cedar wood alcohol is also known as cedrol and cedrol, is widely present in the volatile oil of the various plants such as Cupressaceae, Taxodiaceae and Pinaceae
In.It is applied not only to the production of fragrance, also there is anti-inflammatory, antibacterial, calmness, solution spasm, anti-cardiovascular disease, anti-aging and antitumor
Etc. multiple pharmacological effects and biological activity.
Caulis trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide.Winter to secondary spring is tapped, and is removed impurity, is dried.
Cold nature, bitter.Dispelling wind and removing obstruction in the meridians, cool blood detumescence.For beriberoid pyretic arthralgia, muscle arteries and veins contraction, soreness of waist and knee joint, sore throat, carbuncle swells, falls and flutter damage
Wound.It is distributed in the ground such as Henan, Shandong, Anhui, Jiangsu, Zhejiang, Fujian.
Ginger is the fresh rhizome of Zingiber herbaceos perennial ginger, and rhizome, cork, the Ye Junke of ginger are used as medicine.Ginger exists
There is diverging, preventing or arresting vomiting, cough-relieving and other effects in traditional Chinese medicine and pharmacy.Major function: delivering, cold dispelling, preventing or arresting vomiting opens phlegm.Cure cold chill, vomits
It spits, phlegm retention is breathed with cough, turgor, diarrhea；Solve the tuber of pinellia, rhizoma arisaematis and ichthyophagy crab, birds and beasts meat poisoning.
The dry flower of lilac daphne Isolated From Thymelaeaceae Species lilac daphne, root white skin (double-layer fur) also hyoscine.When spring flower is not open
Harvesting removes impurity.It is dry.Nature and flavor: arduous, temperature.Channel tropism: enter lung, the spleen channel.Major function: removing water retention by purgation；Expelling phlegm and arresting coughing；Solution
Kill worm.Main oedema；Expansion；Phlegm retention hydrothorax；It breathes with cough；Carbuncle furuncle sore tinea.
Pumpkin seed oil is called pumpkin seeds oil, pumpkin seed oil.Pumpkin seed oil is using high-quality pumpkin kernel as raw material, with tradition
Squeezing process refines, and is sufficiently reserved the nutrition essence of pumpkin seed, is the health-nutrition oil for having prominent male health-care effect.
Pumpkin seed oil unsaturated fatty acid rich in, such as linolenic acid, linoleic acid.In addition, pumpkin seed oil also contain phytosterol,
The various bioactivators such as amino acid, vitamin, minerals, especially zinc, magnesium, calcium, phosphorus content are high.
Bulk pharmaceutical chemicals used in the present invention can be commercially available from common pharmacy, and specification meets national medicine mark
It is quasi-.
Further, the present invention provides the preparation method of the hair growth, the externally-applied medicinal composition for promoting hair tonic, packets
Include following steps:
(1) each bulk pharmaceutical chemicals are weighed by parts by weight of the present invention；
(2) it extracts:
Other bulk pharmaceutical chemicals in addition to pumpkin seed oil and cedar wood alcohol are set in extractor, are added water to cook twice, are added for the first time
Enter the water of 8-10 times of weight of total medicinal material, decoct 1-2 hours, take decocting liquid, adds 8-10 times of total medicinal material into the dregs of a decoction for the second time and weigh
The water of amount, decoct 1-2 hour, take twice decocting liquid merging, filtering, be concentrated under reduced pressure into relative density at 60 DEG C be 1.10~
The concentrate of 1.30g/ml, then into concentrate be added 2-3 times of volume ethanol solution, filtering, collect concentrate；
(3) it mixes:
The moisturizer of 50-120 parts by weight is added to concentrate, is uniformly mixed；It is eventually adding pumpkin seed oil and cedar wood alcohol, is stirred
Dissolution is mixed, is uniformly mixed to get the externally-applied medicinal composition.
In method of the present invention, it is preferred that the mass percent concentration of ethanol solution described in step (2) is
70%-80%.
In method of the present invention, it is preferred that moisturizer described in step (3) is selected from glycerol, polyethylene glycol, the third two
The combination of one or more of alcohol, chitin, hyaluronic acid and pyrrolidone sodium carboxylate.
Further, the invention also provides the externally-applied medicinal compositions to prepare hair growth, promote hair tonic
External drug in purposes.
The present invention studies alopecia etiology and pathogenesis on the basis of diagnosis and treatment, using traditional Chinese medicine extraction component, with adjust qi and blood,
Detoxification and removing stasis treats various types of alopecia diseases, and the metabolic function of scalp and hair root nutrients can not only be promoted to inhale
It receives, effective hair growth, and the effect of promoting hair restoration can be reached with activating microcirculation and removing stasis medicinal, hair follicle stimulating growth.It is suitable for
Clinic for hair growth, promotes hair tonic to achieve ideal therapeutic effect.
Specific embodiment
The present invention is further described in conjunction with specific embodiments below by experiment, and the advantages and features of the present invention will be with
Description and it is apparent.But examples are merely exemplary for these, and it is not intended to limit the scope of the present invention in any way.Ability
Field technique personnel should be understood that without departing from the spirit and scope of the invention can be to the details of technical solution of the present invention
It modifies or replaces with form, but these modifications and replacement are fallen within the protection scope of the present invention.
The preparation of 1 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight:
Eclipta 90g, fleece-flower root 45g, mulberry leaf 75g, cacumen biotae 45g, Radix Salviae Miltiorrhizae 75g, cedar wood alcohol 65g, caulis trachelospermi 40g, life
Ginger 40g, lilac daphne 15g and pumpkin seed oil 7g；
(2) it extracts:
Eclipta, the fleece-flower root, mulberry leaf, cacumen biotae, Radix Salviae Miltiorrhizae, caulis trachelospermi, ginger, lilac daphne are set in extractor, added water to cook
Twice, the water of total 10 times of weight of medicinal material is added for the first time, decocts 2 hours, takes decocting liquid, adds total medicinal material into the dregs of a decoction for the second time
The water of 8 times of weight decocts 1.5 hours, takes decocting liquid merging twice, filtering, be concentrated under reduced pressure into relative density is at 60 DEG C
1.20g/ml concentrate.The ethanol solution that the mass percent concentration of 2-3 times of volume is 75% is added into concentrate again,
Concentrate is collected in filtering；
(3) it mixes:
50g glycerol and 50g polyethylene glycol 400 are added into concentrate, is uniformly mixed；It is eventually adding pumpkin seed oil and cypress
Alcohol, stirring and dissolving are uniformly mixed to get medical fluid.
The preparation of 2 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight:
Eclipta 120g, fleece-flower root 60g, mulberry leaf 80g, cacumen biotae 60g, Radix Salviae Miltiorrhizae 80g, cedar wood alcohol 100g, caulis trachelospermi 50g,
Ginger 50g, lilac daphne 20g and pumpkin seed oil 10g；
(2) it extracts:
Eclipta, the fleece-flower root, mulberry leaf, cacumen biotae, Radix Salviae Miltiorrhizae, caulis trachelospermi, ginger, lilac daphne are set in extractor, added water to cook
Twice, the water of total 10 times of weight of medicinal material is added for the first time, decocts 1.5 hours, takes decocting liquid, adds total medicine into the dregs of a decoction for the second time
The water of 9 times of weight of material decocts 1.5 hours, takes decocting liquid merging twice, filtering, be concentrated under reduced pressure into relative density is at 60 DEG C
1.15g/ml concentrate.The ethanol solution that the mass percent concentration of 2-3 times of volume is 80% is added into concentrate again,
Concentrate is collected in filtering；
(3) it mixes:
80g glycerol and 50g propylene glycol are added into concentrate, is uniformly mixed；It is eventually adding pumpkin seed oil and cedar wood alcohol, is stirred
Dissolution is mixed, is uniformly mixed to get medical fluid.
The preparation of 3 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight:
Eclipta 60g, fleece-flower root 30g, mulberry leaf 50g, cacumen biotae 40g, Radix Salviae Miltiorrhizae 50g, cedar wood alcohol 20g, caulis trachelospermi 30g, life
Ginger 25g, lilac daphne 10g and pumpkin seed oil 5g；
(2) it extracts:
Eclipta, the fleece-flower root, mulberry leaf, cacumen biotae, Radix Salviae Miltiorrhizae, caulis trachelospermi, ginger, lilac daphne are set in extractor, added water to cook
Twice, the water of total 8 times of weight of medicinal material is added for the first time, decocts 1.5 hours, takes decocting liquid, adds total medicine into the dregs of a decoction for the second time
The water of 8 times of weight of material decocts 1 hour, takes decocting liquid merging twice, filtering, be concentrated under reduced pressure into relative density is at 60 DEG C
1.20g/ml concentrate.The ethanol solution that the mass percent concentration of 2-3 times of volume is 70% is added into concentrate again,
Concentrate is collected in filtering；
(3) it mixes:
120g polyethylene glycol 400 is added into concentrate, is uniformly mixed；It is eventually adding pumpkin seed oil and cedar wood alcohol, is stirred
Dissolution is uniformly mixed to get medical fluid.
The preparation of 4 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight:
Eclipta 70g, fleece-flower root 60g, mulberry leaf 60g, cacumen biotae 50g, Radix Salviae Miltiorrhizae 80g, cedar wood alcohol 40g, caulis trachelospermi 30g, life
Ginger 30g, lilac daphne 20g and pumpkin seed oil 6g；
(2) it extracts:
Eclipta, the fleece-flower root, mulberry leaf, cacumen biotae, Radix Salviae Miltiorrhizae, caulis trachelospermi, ginger, lilac daphne are set in extractor, added water to cook
Twice, the water of total 10 times of weight of medicinal material is added for the first time, decocts 2 hours, takes decocting liquid, adds total medicinal material into the dregs of a decoction for the second time
The water of 10 times of weight decocts 2 hours, takes decocting liquid merging twice, filtering, being concentrated under reduced pressure into relative density at 60 DEG C is 1.30g/
The concentrate of ml.The ethanol solution that the mass percent concentration of 2-3 times of volume is 80% is added into concentrate again, filters,
Collect concentrate；
(3) it mixes:
The polyethylene glycol 400 of 100g is added into concentrate, is uniformly mixed；It is eventually adding pumpkin seed oil and cedar wood alcohol, is stirred
Dissolution is mixed, is uniformly mixed to get medical fluid.
The preparation of 5 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight:
Eclipta 100g, fleece-flower root 40g, mulberry leaf 80g, cacumen biotae 40g, Radix Salviae Miltiorrhizae 60g, cedar wood alcohol 80g, caulis trachelospermi 50g, life
Ginger 40g, lilac daphne 15g and pumpkin seed oil 10g；
(2) it extracts:
Eclipta, the fleece-flower root, mulberry leaf, cacumen biotae, Radix Salviae Miltiorrhizae, caulis trachelospermi, ginger, lilac daphne are set in extractor, added water to cook
Twice, the water of total 9 times of weight of medicinal material is added for the first time, decocts 2 hours, takes decocting liquid, filters, is added for the second time into the dregs of a decoction total
The water of 9 times of weight of medicinal material decocts 2 hours, takes decocting liquid merging twice, filtering, be concentrated under reduced pressure into relative density is at 60 DEG C
1.20g/ml concentrate.The ethanol solution that the mass percent concentration of 2-3 times of volume is 75% is added into concentrate again,
Concentrate is collected in filtering；
(3) it mixes:
The hyaluronic acid of 80g is added into concentrate, is uniformly mixed；It is eventually adding pumpkin seed oil and cedar wood alcohol, is stirred molten
Solution is uniformly mixed to get medical fluid.
The preparation of 6 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight:
Eclipta 90g, fleece-flower root 45g, mulberry leaf 75g, cacumen biotae 45g, Radix Salviae Miltiorrhizae 75g, cedar wood alcohol 65g and pumpkin seed oil
7g；
(2) it extracts:
Eclipta, the fleece-flower root, mulberry leaf, cacumen biotae, Radix Salviae Miltiorrhizae are set in extractor, added water to cook twice, is added for the first time total
The water of 10 times of weight of medicinal material decocts 2 hours, takes decocting liquid, adds the water of total 8 times of weight of medicinal material into the dregs of a decoction for the second time, decocts
1.5 hours, decocting liquid merging twice is taken, filtering, being concentrated under reduced pressure into relative density at 60 DEG C is the concentrate of 1.10g/ml.It is past again
The ethanol solution that the mass percent concentration of 2-3 times of volume is 75% is added in concentrate, concentrate is collected in filtering；
(4) it mixes:
The glycerol and 50g pyrrolidone sodium carboxylate of 60g are added into concentrate, is uniformly mixed；Be eventually adding cedar wood alcohol and
Pumpkin seed oil, stirring and dissolving are uniformly mixed to get medical fluid.
The preparation of 7 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight:
Eclipta 70g, fleece-flower root 60g, mulberry leaf 60g, cacumen biotae 50g, Radix Salviae Miltiorrhizae 80g, cedar wood alcohol 40g and pumpkin seed oil
6g；
(2) it extracts:
Eclipta, the fleece-flower root, mulberry leaf, cacumen biotae, Radix Salviae Miltiorrhizae are set in extractor, added water to cook twice, is added for the first time total
The water of 9 times of weight of medicinal material decocts 2 hours, takes decocting liquid, adds the water of total 8 times of weight of medicinal material into the dregs of a decoction for the second time, decocts
1.5 hours, decocting liquid merging twice is taken, filtering, being concentrated under reduced pressure into relative density at 60 DEG C is the concentrate of 1.15g/ml.It is past again
The ethanol solution that the mass percent concentration of 2-3 times of volume is 75% is added in concentrate, concentrate is collected in filtering；
(4) it mixes:
70g polyethylene glycol 400 and 50g chitin are added into concentrate, is uniformly mixed；It is eventually adding cedar wood alcohol and pumpkin
Seed oil, stirring and dissolving are uniformly mixed to get medical fluid.
The preparation of 8 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight:
Eclipta 100g, fleece-flower root 40g, mulberry leaf 80g, cacumen biotae 40g, Radix Salviae Miltiorrhizae 60g, cedar wood alcohol 80g and pumpkin seed oil
10g；
(2) it extracts:
Eclipta, the fleece-flower root, mulberry leaf, cacumen biotae, Radix Salviae Miltiorrhizae are set in extractor, added water to cook twice, is added for the first time total
The water of 8 times of weight of medicinal material decocts 1.5 hours, takes decocting liquid, adds the water of total 8 times of weight of medicinal material into the dregs of a decoction for the second time, decocts
1 hour, decocting liquid merging twice is taken, filtering, being concentrated under reduced pressure into relative density at 60 DEG C is the concentrate of 1.20g/ml.Again toward dense
The ethanol solution that the mass percent concentration of 2-3 times of volume is 80% is added in contracting liquid, concentrate is collected in filtering；
(3) it mixes:
60g glycerol and 50g hyaluronic acid are added into concentrate, is uniformly mixed；It is eventually adding cedar wood alcohol and pumpkin seed oil,
Stirring and dissolving is uniformly mixed to get medical fluid.
Pharmacodynamics test of the pharmaceutical composition of the invention of experimental example 1 to mouse hair growth
Experimental material: the externally-applied medicinal composition of anthology inventive embodiments 1, embodiment 2, embodiment 3, embodiment 6；101
Hair-loss preventing and hair-restoring agent (Beijing Zhangguang 101 Technology Co., Ltd., product batch number: 20120301)；Distilled water.
60 inbred mouses are taken, cleaning grade is female, 6-7 week old, and weight 18-20g is numbered by weight, is divided into 6 groups, adopts
It is divided into pharmaceutical composition example 1 group, 2 groups of embodiment, 3 groups of embodiment, 6 groups of embodiment, positive control with random alignment table method
Group (smearing 101 hair-loss preventing and hair-restoring agent), blank control group (smearing distilled water), every group 10.Mouse after etherization with rosin/
Mineral wax mixture (1: 1) heat is applied to back after melting, it is to be solidified be hardened after throw off, smooth with back of mice, no wound is without hair root
Only, its hair is induced to enter growth period by stand-down, lose hair or feathers area about 2cm × 2cm.Respectively at hair removal section from the 2nd day after depilation
Relative medicine is smeared, 2 times a day, each 0.2mL/ only, is observed continuously 30 days.
1, mouse epilation position goes out the situation of change of hair time
From after coating the 2nd day, the variation of the observation back of mice epilation daily color of area skin determined the growth of hair follicle
State and the intuitive observation hair removal section hair growth situation of naked eyes, record every mouse and hair-fields skin color are gone to be become by pink
Time of grey, grey are to growing mao time and cover with the time of hair.
Experimental result is as shown in table 1, and after mouse depilation, pink is presented in skin, and hair enters stand-down, 6~7d of coating
Example 1 group starts blackening afterwards, starts blackening for 2 groups of embodiment after 6~8d, after 7~9d, 3 groups of embodiment, 6 groups of embodiment and sun
Property control group skin starts to black, and after 13~15d, blank group starts blackening.There is conspicuousness between each group and blank control group
Difference, wherein example 1 group, there are significant difference (P < 0.05) with positive controls for 2 groups of embodiment；After 13~14d of coating
2 groups of dark skins of example 1 group and embodiment start it is elongated go out hair, after 14~16d, 3 groups of embodiment, 6 groups of embodiment and sun
Property control group dark skin starts to grow hair, and after 19~20d, blank group starts to grow hair.Each group is equal with blank control group
Have a significant difference, example 1 group, 2 groups of embodiment and positive controls there are significant difference (P < 0.05), 3 groups of embodiment,
There was no significant difference between positive controls for 6 groups of embodiment；After 26~30d is administered, positive controls and embodiment each group are equal
Hair is covered with, and there are extremely significant sex differernce (P < 0.01), 2 groups of embodiment and positive controls with positive controls for example 1 group
There is also significant difference (P < 0.05) for group.
1 each group back of mice of table epilation area's skin color transformation period compares (x ± s, n=10)
| Group | Skin is pink to arrive the graying time | Ashen skin grows a mao time | Skin covers with a mao time |
| Blank control group | 14.86±1.36 | 20.02±0.56 | 30.16±0.91 |
| Example 1 group | 7.25±0.34* | 14.23±0.96* | 27.19±0.32** |
| 2 groups of embodiment | 7.86±1.03* | 14.98±1.06* | 27.56±0.35* |
| 3 groups of embodiment | 8.51±0.96 | 15.65±0.75 | 28.21±0.36 |
| 6 groups of embodiment | 8.65±1.12 | 15.32±1.03 | 28.16±1.32 |
| Positive controls | 8.43±0.84 | 15.23±0.89 | 28.94±0.35 |
Note: compared with positive controls control group, * P < 0.05, P < 0.01 * *.
2, to the situation of change of mouse neonatal hair length and weight
It tests last day cervical dislocation and puts to death mouse, take and most become mildewed 3 in every mouse bilateral hair removal section antimere, swim
Calliper to measure length is marked, and calculates average value, as each mouse hair removal section new life hair length；Test block hair removal section skin is taken simultaneously
Skin (4cm2), same size skin graft is laid with punch, whole hairs on skin graft is removed and weighs, as each mouse neonatal hair
Weight.
Experimental result is as shown in table 2, example 1 group, 2 groups of embodiment, 3 groups of embodiment, 6 groups of embodiment and positive controls
The newborn staple length and weight of mouse are significantly increased compared with blank, and it is poor to there is with blank control group extremely significant property between each group
Not, wherein example 1 group and 2 groups of embodiment of newborn staple length and weight with positive controls there are difference (P <
0.05)。
The comparison (x ± s, n=10) of 2 each group back of mice new life hair length of table and weight
| Group | Newborn hair length (mm) | New piliation weight (mg) |
| Blank control group | 4.12±0.74 | 2.11±0.14 |
| Example 1 group | 8.73±0.75* | 4.77±0.86* |
| 2 groups of embodiment | 8.51±1.11* | 4.36±0.21* |
| 3 groups of embodiment | 7.14±0.46 | 3.89±0.25 |
| 6 groups of embodiment | 7.58±0.73 | 3.13±0.47 |
| Positive controls | 7.42±0.48 | 3.44±0.35 |
Note: compared with positive controls control group, * P < 0.05.
3, each group back of mice skin major histological situation of change
It tests last day cervical dislocation and puts to death mouse, by every mouse hair removal section skin (4cm2) gross weight removes, take wherein
Ten needle hair film-makings, microphotograph and the variation for observing hair follicle.Finally by the skin histology of test block, fixed with 10% formaldehyde,
It is organized along hair follicle longitudinal direction section, carries out conventional organization dehydration, paraffin embedding, HE dyeing, light microscopic microscopy observes mouse skin group
It knits.Observation item includes: (1) high dermis blood vessels caliber (um), (2) high dermis blood vessel number (a), with 200 times of visual field sizes
It counts (3) high dermis hair follicles outgrowth number (a), with 100 times of big subtotal figures in the visual field.
Experimental result is as shown in table 3, example 1 group, 2 groups of embodiment, 3 groups of embodiment, 6 groups of embodiment and positive controls
To the high dermis hair follicles outgrowth number, high dermis blood vessel number, high dermis blood vessels caliber of mouse skin compared with blank control group
There is difference, wherein the high dermis hair follicles outgrowth number of example 1 group mouse skin, high dermis blood vessel number, corium are shallow
Layer blood vessels caliber and positive controls have extremely significant gender gap (P < 0.01), and the high dermis of 2 groups of mouse skins of embodiment is newborn
Hair follicle number, high dermis blood vessel number, high dermis blood vessels caliber and positive controls have difference (P < 0.05).
3 each group back of mice skin major histological of table changes (x ± s, n=10)
Note: compared with positive controls control group, * P < 0.05, * * P < 0.01.
In summary three the experimental results showed that, pharmaceutical composition provided by the invention can effectively promote the new old of scalp
Metabolic function and hair root nutrients absorb, and achieve the purpose that effective hair growth, pass through mouse high dermis hair follicle number, capillary
It is tested with blood vessels caliber, more it can be seen that pharmaceutical composition of the invention can increase local amount of blood supply, improves local microcirculation,
Reinforce hair follicle nutrition, promote hair growth and regeneration, by activating microcirculation and removing stasis medicinal come hair follicle stimulating growth, more general product for improving hair-growing is more
The palingenesis that hair can be excited, the therapeutic effect for being finally reached hair growth, promoting hair tonic, and cheap, production technology
Simply, it is suitble to clinical use and large-scale production.
Claims (10)
1. a kind of for hair growth, the externally-applied medicinal composition of promotion hair tonic, which is characterized in that by the original of following parts by weight
Material medicine is made: 60-120 parts of eclipta, 30-60 parts of the fleece-flower root, 50-100 parts of mulberry leaf, 30-60 parts of cacumen biotae, Radix Salviae Miltiorrhizae 50-100
Part, 20-110 parts of cedar wood alcohol and 5-10 parts of pumpkin seed oil.
2. externally-applied medicinal composition according to claim 1, which is characterized in that by the bulk pharmaceutical chemicals system of following parts by weight
At: 80-100 parts of eclipta, 40-50 parts of the fleece-flower root, 60-90 parts of mulberry leaf, 30-60 parts of cacumen biotae, 60-90 parts of Radix Salviae Miltiorrhizae, cedar wood alcohol
40-90 parts and 5-10 parts of pumpkin seed oil.
3. externally-applied medicinal composition according to claim 2, which is characterized in that by the bulk pharmaceutical chemicals system of following parts by weight
At: 90 parts of eclipta, 45 parts of the fleece-flower root, 75 parts of mulberry leaf, 45 parts of cacumen biotae, 75 parts of Radix Salviae Miltiorrhizae, 65 parts of cedar wood alcohol and pumpkin seed oil 7
Part.
4. a kind of for hair growth, the externally-applied medicinal composition of promotion hair tonic, which is characterized in that by the original of following parts by weight
Material medicine is made: 60-120 parts of eclipta, 30-60 parts of the fleece-flower root, 50-100 parts of mulberry leaf, 30-60 parts of cacumen biotae, Radix Salviae Miltiorrhizae 50-100
Part, 20-110 parts of cedar wood alcohol, 30-50 parts of caulis trachelospermi, 25-55 parts of ginger, 10-20 parts of lilac daphne and 5-10 parts of pumpkin seed oil.
5. externally-applied medicinal composition according to claim 4, which is characterized in that by the bulk pharmaceutical chemicals system of following parts by weight
At: 80-100 parts of eclipta, 40-50 parts of the fleece-flower root, 60-90 parts of mulberry leaf, 30-60 parts of cacumen biotae, 60-90 parts of Radix Salviae Miltiorrhizae, cedar wood alcohol
40-90 parts, 35-45 parts of caulis trachelospermi, 30-45 parts of ginger, 10-15 parts of lilac daphne and 5-10 parts of pumpkin seed oil.
6. externally-applied medicinal composition according to claim 5, which is characterized in that by the bulk pharmaceutical chemicals system of following parts by weight
At: 90 parts of eclipta, 45 parts of the fleece-flower root, 75 parts of mulberry leaf, 45 parts of cacumen biotae, 75 parts of Radix Salviae Miltiorrhizae, 65 parts of cedar wood alcohol, 40 parts of caulis trachelospermi,
40 parts of ginger, 15 parts of lilac daphne and 7 parts of pumpkin seed oil.
7. a kind of method for preparing 1-6 described in any item externally-applied medicinal compositions of claim, which is characterized in that the system
Preparation Method the following steps are included:
(1) each bulk pharmaceutical chemicals are weighed by parts by weight described in any one of claims 1-6；
(2) it extracts:
Other bulk pharmaceutical chemicals in addition to pumpkin seed oil and cedar wood alcohol are set in extractor, are added water to cook twice, are added for the first time total
The water of 8-10 times of weight of medicinal material decocts 1-2 hours, takes decocting liquid, adds 8-10 times of weight of total medicinal material into the dregs of a decoction for the second time
Water decocts 1-2 hours, takes decocting liquid merging twice, filtering, being concentrated under reduced pressure into relative density at 60 DEG C is 1.10~1.30g/ml
Concentrate, then into concentrate be added 2-3 times of volume ethanol solution, filtering, collect concentrate；
(3) it mixes:
The moisturizer of 50-120 parts by weight is added to concentrate, is uniformly mixed；It is eventually adding pumpkin seed oil and cedar wood alcohol, is stirred molten
Solution is uniformly mixed to get the externally-applied medicinal composition.
8. preparation method according to claim 7, which is characterized in that the quality percentage of ethanol solution described in step (2)
Specific concentration is 70%-80%.
9. preparation method according to claim 7, which is characterized in that moisturizer described in step (3) is selected from glycerol, gathers
The combination of one or more of ethylene glycol, propylene glycol, chitin, hyaluronic acid and pyrrolidone sodium carboxylate.
10. externally-applied medicinal composition described in any one of claims 1-6 is in the external drug for preparing hair growth, promoting hair tonic
In purposes.
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| CN107890556A (en) * | 2017-12-04 | 2018-04-10 | 张致恒 | A kind of Traditional Chinese medicine tincture preparation of hair growth and preparation method thereof |
| KR102171818B1 (en) * | 2018-01-18 | 2020-10-29 | (주)나디안바이오 | Composition for preventing or alleviating alopecia containing dunnione as an active ingredient |
| CN111265592A (en) * | 2019-12-31 | 2020-06-12 | 云南素颜素心生物科技有限公司 | Agent for hair or scalp and method for producing the same |
| CN112206249A (en) * | 2020-10-13 | 2021-01-12 | 安徽大学 | Medicine for treating female alopecia and preparation method thereof |
| CN113730452A (en) * | 2021-10-12 | 2021-12-03 | 遵义医科大学 | Application of eclipta petroleum ether extract in preparation of preparation for preventing and/or treating chemotherapy-induced alopecia |
| CN115779028B (en) * | 2022-08-30 | 2024-05-07 | 北京博奥晶方生物科技有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100928A (en) * | 1993-09-27 | 1995-04-05 | 王本喜 | Hair growth liquor and preparation method thereof |
| CN1305800A (en) * | 2000-12-05 | 2001-08-01 | 廖启明 | Hair-protecting ginseng lotion |
| CN103655890A (en) * | 2012-09-18 | 2014-03-26 | 青岛医防消毒专业技术中心 | Compound liniment for preventing and treating alopecia areata |
| CN104548011A (en) * | 2014-12-29 | 2015-04-29 | 余德常 | Hair generating and growing agent and production process thereof |
| CN104623089A (en) * | 2015-01-09 | 2015-05-20 | 赵义军 | Health composition for preventing alopecia, protecting hairs and blackening hairs |
-
2016
- 2016-10-27 CN CN201610975084.XA patent/CN106511924B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100928A (en) * | 1993-09-27 | 1995-04-05 | 王本喜 | Hair growth liquor and preparation method thereof |
| CN1305800A (en) * | 2000-12-05 | 2001-08-01 | 廖启明 | Hair-protecting ginseng lotion |
| CN103655890A (en) * | 2012-09-18 | 2014-03-26 | 青岛医防消毒专业技术中心 | Compound liniment for preventing and treating alopecia areata |
| CN104548011A (en) * | 2014-12-29 | 2015-04-29 | 余德常 | Hair generating and growing agent and production process thereof |
| CN104623089A (en) * | 2015-01-09 | 2015-05-20 | 赵义军 | Health composition for preventing alopecia, protecting hairs and blackening hairs |
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Effective date of registration: 20171018 Address after: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Applicant after: HARBIN KUAIHAO PHARMACEUTICAL CO.,LTD. Address before: 150025 middle section of Beijing Road, Limin economic and Technological Development Zone, Harbin City, Heilongjiang Applicant before: LOCTITE HARBIN PHARMACEUTICAL Co.,Ltd. |
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Address after: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Patentee after: Letai Pharmaceutical Co.,Ltd. Address before: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Patentee before: HARBIN KUAIHAO PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20200724 Address after: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Co-patentee after: Heilongjiang Letai Pharmaceutical Co.,Ltd. Patentee after: Letai Pharmaceutical Co.,Ltd. Address before: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Patentee before: Letai Pharmaceutical Co.,Ltd. |
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Address after: 150025 Zhuhai Road, Limin development area, Hulan District, Harbin, Heilongjiang, China Patentee after: Letai Pharmaceutical Co.,Ltd. Patentee after: Loctite Pharmaceutical (Lanxi) Co.,Ltd. Address before: 150025 Zhuhai Road, Limin development area, Hulan District, Harbin, Heilongjiang, China Patentee before: Letai Pharmaceutical Co.,Ltd. Patentee before: Heilongjiang Letai Pharmaceutical Co.,Ltd. |
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