CN105362511B - A kind of Chinese medicine composition and its preparation for treating fibroid - Google Patents
A kind of Chinese medicine composition and its preparation for treating fibroid Download PDFInfo
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- CN105362511B CN105362511B CN201510909680.3A CN201510909680A CN105362511B CN 105362511 B CN105362511 B CN 105362511B CN 201510909680 A CN201510909680 A CN 201510909680A CN 105362511 B CN105362511 B CN 105362511B
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Abstract
The invention discloses a kind of Chinese medicine composition for treating fibroid, including 100 180 parts of Poria cocos, 70 120 parts of cattail pollens, 5 15 portions of pseudo-ginseng, 80 120 parts of cassia twig, 30 70 parts of safflowers, 80 130 portions of radix cyathulaes, 75 115 parts of Radix Salviae Miltiorrhizaes, 80 125 parts of radix paeoniae rubrathe, 80 110 portions of motherworts, 80 110 parts of peach kernels, 120 160 portions of ecliptas and 80 120 parts of Herba Lycopi.Using a kind of Chinese medicine composition for treating fibroid provided by the present invention, fibroid significant effect is cured, curative effect is fast.
Description
Technical field
The present invention relates to technical field of Chinese medicine, more particularly to a kind of Chinese medicine composition and its system for treating fibroid
Agent.
Background technology
Fibroid is made of smooth muscle and connective tissue, therefore also known as leiomyoma of uterus, is that women is most normal
The benign tumour seen.More than 90% Uterine Leiomyoma is in corpus.It forms more and deficiency of vial QI, disorder of qi and blood, gas
The stagnant product block for waiting condensation to form of blood stasis.This disease belongs to traditional Chinese medical science uterine bleeding, Disorder lumps in the abdomen, stone lump in the abdomen category.The multi-purpose promoting the circulation of qi blood-breaking of clinic, softening hardness to remove stagnation of food
Method, tonification and purgation in combination, Coryza Treated by Syndrome Differentiation.Due to definite etiology unknown, modern Western medicine takes sex hormone or surgical resection therapy, still
Without other preferable therapies.Operative treatment causes local failure to the whole organ of human body, and add patient pain and
Financial burden, inevitably produces sequelae after operation.
Currently on the market treat fibroid Chinese patent drug kind it is very few, it is impossible to satisfy social needs, on the other hand these
The effect of old kind medicine is not still especially desirable, there is the traditional Chinese patent medicine that curative effect yet-to-be developed further improves.
The content of the invention
In view of this, the present invention provides a kind of Chinese medicine composition for treating fibroid, solution to treat currently on the market
The problem of Chinese patent drug less varieties of fibroid, unsatisfactory curative effect.
The technological means that the present invention uses is as follows：A kind of Chinese medicine composition for treating fibroid, including following parts by weight
Component：100-180 parts of Poria cocos, 70-120 parts of cattail pollens, 5-15 portions of pseudo-ginseng, 80-120 parts of cassia twig, 30-70 parts of safflowers, 80-130
Part radix cyathulae, 75-115 parts of Radix Salviae Miltiorrhizaes, the 80-125 parts of radix paeoniae rubrathe, 80-110 portions of motherworts, 80-110 parts of peach kernels, 120-160 parts of ink droughts
Lotus and 80-120 parts of Herba Lycopi.
Preferably, a kind of Chinese medicine composition for treating fibroid includes the component of following parts by weight：150 parts of Poria cocos, 100
Part cattail pollen, 10 portions of pseudo-ginseng, 100 parts of cassia twig, 50 parts of safflowers, 100 portions of radix cyathulaes, 100 parts of Radix Salviae Miltiorrhizaes, 100 parts of radix paeoniae rubrathe, 100 parts of benefits are female
Grass, 100 parts of peach kernels, 150 portions of ecliptas and 100 parts of Herba Lycopi.
Preferably, a kind of active ingredient for the preparation for treating fibroid is a kind of Chinese traditional medicine composition for treating fibroid
Thing.
Preferably, a kind of preparation for treating fibroid is one kind in capsule, particle or oral liquid.
Using a kind of Chinese medicine composition for treating fibroid provided by the present invention, fibroid significant effect is cured,
Curative effect is fast.
Embodiment
The principles and features of the present invention are described below, and illustrated embodiment is served only for explaining the present invention, is not intended to
Limit the scope of the present invention.
Following basis《Chinese Pharmacopoeia》、《Dictionary of medicinal plant》And《Chinese draft》Introduce source, the shape of primary raw material medicine
The basic conditions such as shape, performance and application.
Poria cocos：For the dry sclerotia of Polyporaceae plant Poria cocos.
Medicine materical crude slice character：This product is in blockage, and about 6-10 millimeters of diameter, off-white color, matter is hard, it is lightly seasoned chew stick to one's teeth.
Physics and chemistry differentiates：Take Indian buead tablet or powder a small amount of, add potassium iodide test solution 1 to drip, in peony.
Cattail pollen：For Typhaceae plant raupo and its belong to the dry pollen of other plant together.
Medicine materical crude slice character：This product is in foresythia fine powder, and hand sth. made by twisting has lubrication to feel, and easily enters water on attachment finger and do not sink, taste
It is light.
Physics and chemistry differentiates：This product 0.2g is taken, adds water 10ml, temperature leaching, filtration, takes filtrate 1ml to add ferric trichloride test solution 1 to drip, be in
Light green is to brown.
Pseudo-ginseng：For the dry root of panax araliaceae plant.
Medicine materical crude slice character：This product is slightly in spindle or class cone, and 1-6 centimetres long, there is footpath trace on top, around has warty to dash forward
Go out, surface is smooth, and grey sepia, matter is solid, smashes rear skin zone and is often separated with woody part, cross section celadon or yellow green, center
Xylem is deeper, and cutin shape has a radial texture, sweet tea after bitter.
Microscopical characters：Powder lark；How irregular amylum body Quito, shape be；Resin canal fragment secretion containing yellow；It is even
You see calcium oxalate cluster crystal.
Cassia twig：For the dry twig of rutaceae Chinese cassia tree.
Medicine materical crude slice character：This product is thin slice, and surface brown to rufous, matter is hard and crisp, frangibility, and section skin zone is thin in brown red
Color, woody part yellow-white to lark, there is special fragrance, sweet pungent, and skin zone's taste is denseer.
Safflower：For the dry flower of feverfew safflower.
Medicine materical crude slice character：Floral tube shape, surface reddish yellow or red, tube is elongated, and upper end 5 is split, gas micro-perfume, mildly bitter flavor.
Microscopical characters：This product powder is orange-yellow；Corolla, filigree, column cap fragment are common, have elongated tubular secretory cell, containing Huang
Brown is to rufous secretion；Pollen grain similar round, ellipse or olive shape；Calcium oxalate prismatic crystal is present in parenchyma cell.
Radix cyathulae：For the dry root of amaranthaceous plant radix cyathulae.
Medicine materical crude slice shape：This product is in slab-like, surface brown color or taupe, and matter is flexible, is not easily broken, and cross section is light yellow
Or brown color, and having grease exudation, it is seen that many yellow dots are arranged in several layers of concentric ring, sweet.
Microscopical characters：This product cross section phellem layer is ordered series of numbers cell, cortex is relatively narrow, and vascular bundle intermittent arrangement is taken turns into 2-4, shape
Stratification connection cyclization, xylem are made of conduit, wood-fibred and parenchyma cell, and juvenile wood integrates 2-3 groups, and parenchyma cell contains
Calcium oxalate sand crystal.
Radix Salviae Miltiorrhizae：For the yellow dry cauline leaf of labiate pachyrhizus.
Medicine materical crude slice shape：This product is in oblique sheet, surface brownish red or reddish dark brown more, section skin zone brownish red, woody part sallow
Color or puce, it is seen that yellow-white point-like fibre bundle.It is mildly bitter flavor, puckery.
Physics and chemistry differentiates：Powder 5g is taken, adds water 50ml, decocts 15-20 minutes, lets cool, is filtered, filtrate is put and is concentrated into water-bath
Thick, after letting cool plus ethanol 3-5ml is allowed to dissolve, and filters, and access drop filtrate is dropped on filter paper bar, is seen under dry postposition ultraviolet lamp
Examine, in light blue grey fluorescence.
The radix paeoniae rubrathe：For the dry root of cohosh Chinese herbaceous peony.
Medicine materical crude slice shape：This product is in slab-like, surface skin crineous or sepia, unilateral white powder or pink, completely
The visible flaxen chrysanthemum texture of section, gas micro-perfume, bitter and puckery flavor.
Physics and chemistry differentiates：This product powder 0.5g is taken, adds water 10ml to boil, is filtered, filtrate adds ferric trichloride test solution 1 to drip, and generates
Black-and-blue precipitation.
Motherwort：For the drying herb of labiate motherwort.
Medicine materical crude slice shape：This product is in section shape, and stem is square, and section has the marrow of white, and leaf comes off more or shrinkage, complete person lower part
Leaf palmate 3 is split, upper leaf pinniform drastic crack or it is shallow be cleaved into 3, take turns umbrella inflorescence axillary, bract thorn-like, corolla has often fallen de-, calyx cylinder
Shape, acrid flavour are bitter.
Peach kernel：For the dry mature seed of rosaceous plant peach and mountain peach.
Medicine materical crude slice shape：Seed long avette, flat, top point, middle part expands, base portion blunt circle and deflection, plant Beijing opera brown or
Rufous, mildly bitter flavor.
Net peach kernel is taken to put in boiling water pot, heating is scalded to kind skin microdilatancy, is pulled out to be put in cold water and is slightly steeped, and kind of a skin is removed in stranding, is shone
Kernel-taking after dry.
Eclipta：For the drying herb of feverfew Eclipta prostrata.
Medicine materical crude slice character：This product is section shape, and the green and brown color of stem cylinder, leaf rolling shrinkage or broken, complete person drapes over one's shoulders point in length
The green and brown color of shape, full edge or the shallow tooth of tool, it is in then black to rub its cauline leaf after immersion with the hands, lightly seasoned micro- salty.
Herba Lycopi：For the yellow dry cauline leaf of labiate.
Medicine materical crude slice character：This product is section shape, and stem is square, surface yellowish-brown or with purple, and purple at section, matter is crisp easily broken, section
Yellow-white, marrow is more in cavity.Leaf is to life, dirty-green or micro-strip yellow, and more shrinkages, it is in lanceolar oval to be unfolded, first end margin
There is a sawtooth, remaining bract and sepal after visible flowers come off between axil are lightly seasoned.
Embodiment one：
A kind of Chinese medicine composition for treating fibroid, including 100g Poria cocos, 70g cattail pollens, 5g pseudo-ginseng, 80g cassia twig, 30g
Safflower, 80g radix cyathulaes, 75g Radix Salviae Miltiorrhizaes, the 80g radix paeoniae rubrathe, 80g motherworts, 80g peach kernels, 120g ecliptas and 80g Herba Lycopi.
A kind of method that Chinese medicine composition for treating fibroid prepares capsule comprises the following steps：
Step 1：70g cattail pollens are taken, when being fried with moderate heat to sepia, proper amount of clear water is sprayed, takes out, airing, dry be made is fried
Cattail pollen；
Step 2：The 80g radix paeoniae rubrathe, 70g is taken to fry cattail pollen, 5g pseudo-ginseng and put in drying box, with 70 DEG C of dryings, co-grinding is into coarse powder
It is spare；
Step 3：By 100g Poria cocos, 80g cassia twig, 30g safflowers, 80g radix cyathulaes, 75g Radix Salviae Miltiorrhizaes, 80g motherworts, 80g peaches
Benevolence, 120g ecliptas and 80g Herba Lycopi are placed in jacketed pan, and amount of water is higher by powder about 15-20cm and boils twice, every time 1.5 it is small when,
Merge liquid twice, it is 1.25 clear creams to be concentrated into proportion, spare；
Step 4：The coarse powder of clear cream and step 2 is mixed into softwood, coarse granule is made, is placed in drying box, with 70 DEG C
Fine powder is dry, pulverize into, loads capsule shells, up to capsule.
Embodiment two：
A kind of Chinese medicine composition for treating fibroid, including 150g Poria cocos, 100g cattail pollens, 10g pseudo-ginseng, 100g cassia twig,
50g safflowers, 100g radix cyathulaes, 100g Radix Salviae Miltiorrhizaes, the 100g radix paeoniae rubrathe, 100g motherworts, 100g peach kernels, 150g ecliptas and 100g pools
It is blue.
A kind of method that Chinese medicine composition for treating fibroid prepares capsule comprises the following steps：
Step 1：100g cattail pollens are taken, when being fried with moderate heat to sepia, proper amount of clear water is sprayed, takes out, airing, it is dry to be made
Fry cattail pollen；
Step 2：Take the 100g radix paeoniae rubrathe, 100g to fry cattail pollen, 10g pseudo-ginseng and put in drying box, with 70 DEG C of dryings, co-grinding into
Coarse powder is spare；
Step 3：By 150g Poria cocos, 100g cassia twig, 50g safflowers, 100g radix cyathulaes, 100g Radix Salviae Miltiorrhizaes, 100g motherworts,
100g peach kernels, 150g ecliptas and 100g Herba Lycopi are placed in jacketed pan, and amount of water is higher by powder about 15-20cm and boils twice, every time
1.5 it is small when, merge liquid twice, it is 1.25 clear creams to be concentrated into proportion, spare；
Step 4：The coarse powder of clear cream and step 2 is mixed into softwood, coarse granule is made, is placed in drying box, with 70 DEG C
Fine powder is dry, pulverize into, loads capsule shells, up to capsule.
Embodiment three：
A kind of Chinese medicine composition for treating fibroid, including 180g Poria cocos, 120g cattail pollens, 15g pseudo-ginseng, 120g cassia twig,
70g safflowers, 130g radix cyathulaes, 115g Radix Salviae Miltiorrhizaes, the 125g radix paeoniae rubrathe, 110g motherworts, 110g peach kernels, 160g ecliptas and 120g pools
It is blue.
A kind of method that Chinese medicine composition for treating fibroid prepares capsule comprises the following steps：
Step 1：120g cattail pollens are taken, when being fried with moderate heat to sepia, proper amount of clear water is sprayed, takes out, airing, it is dry to be made
Fry cattail pollen；
Step 2：Take the 125g radix paeoniae rubrathe, 120g to fry cattail pollen, 15g pseudo-ginseng and put in drying box, with 70 DEG C of dryings, co-grinding into
Coarse powder is spare；
Step 3：By 180g Poria cocos, 120g cassia twig, 70g safflowers, 130g radix cyathulaes, 115g Radix Salviae Miltiorrhizaes, 110g motherworts,
110g peach kernels, 160g ecliptas and 120g Herba Lycopi are placed in jacketed pan, and amount of water is higher by powder about 15-20cm and boils twice, every time
1.5 it is small when, merge liquid twice, it is 1.25 clear creams to be concentrated into proportion, spare；
Step 4：The coarse powder of clear cream and step 2 is mixed into softwood, coarse granule is made, is placed in drying box, with 70 DEG C
Fine powder is dry, pulverize into, loads capsule shells, up to capsule.
Example IV：
A kind of Chinese medicine composition for treating fibroid, including 100g Poria cocos, 100g cattail pollens, 15g pseudo-ginseng, 110g cassia twig,
70g safflowers, 130g radix cyathulaes, 100g Radix Salviae Miltiorrhizaes, the 120g radix paeoniae rubrathe, 110g motherworts, 110g peach kernels, 160g ecliptas and 120g pools
It is blue.
A kind of method that Chinese medicine composition for treating fibroid prepares capsule comprises the following steps：
Step 1：100g cattail pollens are taken, when being fried with moderate heat to sepia, proper amount of clear water is sprayed, takes out, airing, it is dry to be made
Fry cattail pollen；
Step 2：Take the 120g radix paeoniae rubrathe, 100g to fry cattail pollen, 15g pseudo-ginseng and put in drying box, with 70 DEG C of dryings, co-grinding into
Coarse powder is spare；
Step 3：By 100g Poria cocos, 110g cassia twig, 70g safflowers, 130g radix cyathulaes, 100g Radix Salviae Miltiorrhizaes, 110g motherworts,
110g peach kernels, 160g ecliptas and 120g Herba Lycopi.It is placed in jacketed pan, amount of water is higher by powder about 15-20cm and boils twice, every time
1.5 it is small when, merge liquid twice, it is 1.25 clear creams to be concentrated into proportion, spare；
Step 4：The coarse powder of clear cream and step 2 is mixed into softwood, coarse granule is made, is placed in drying box, with 70 DEG C
Fine powder is dry, pulverize into, loads capsule shells, up to capsule.
Embodiment five：
A kind of Chinese medicine composition for treating fibroid, including 120g Poria cocos, 120g cattail pollens, 8g pseudo-ginseng, 100g cassia twig,
50g safflowers, 80g radix cyathulaes, 75g Radix Salviae Miltiorrhizaes, the 110g radix paeoniae rubrathe, 100g motherworts, 110g peach kernels, 150g ecliptas and 110g Herba Lycopi.
A kind of method that Chinese medicine composition for treating fibroid prepares capsule comprises the following steps：
Step 1：120g cattail pollens are taken, when being fried with moderate heat to sepia, proper amount of clear water is sprayed, takes out, airing, it is dry to be made
Fry cattail pollen；
Step 2：The 120g radix paeoniae rubrathe, 100g is taken to fry cattail pollen, 8g pseudo-ginseng and put in drying box, with 70 DEG C of dryings, co-grinding is into thick
Powder is spare；
Step 3：By 120g Poria cocos, 100g cassia twig, 50g safflowers, 80g radix cyathulaes, 75g Radix Salviae Miltiorrhizaes, 100g motherworts, 110g
Peach kernel, 150g ecliptas and 110g Herba Lycopi.It is placed in jacketed pan, amount of water is higher by powder about 15-20cm and boils twice, and every time 1.5
Hour, merge liquid twice, it is 1.25 clear creams to be concentrated into proportion, spare；
Step 4：The coarse powder of clear cream and step 2 is mixed into softwood, coarse granule is made, is placed in drying box, with 70 DEG C
Fine powder is dry, pulverize into, loads capsule shells, up to capsule.
Reference examples：The GUIZHI FULING JIAONANG of in the market
Clinical trial curative effect：
Capsule is made in embodiment one to five, comparative example and makees clinical trial, 60 palace myomata cases are randomly divided into two groups,
Every group of 15 cases, one group for the treatment of, two groups for the treatment of, three groups for the treatment of, four groups for the treatment of, treatment five groups and control group.Palace myomata case
Diagnostic criteria be：Hyper-menorrhea or menostaxis, or Irregular vagina bleeding, inferior belly gas pain or pain, the soreness of waist, abortion, no
It is pregnant.There is the solid tumor mass of clear border in B ultrasound prompting uterine wall, you can be diagnosed as palace myomata.
The each grammes per square metre of capsule prepared by the embodiment of the present invention one to 5 is 3g, and administrated method and the course for the treatment of are respectively：
Treat one group：The capsule 5 of the preparation of the embodiment of the present invention one is once taken, three times a day, warm water delivery service, 3
Month 1 course for the treatment of.
Treat two groups：The capsule 5 of the preparation of the embodiment of the present invention two is once taken, three times a day, warm water delivery service, 3
Month 1 course for the treatment of.
Treat three groups：The capsule 5 of the preparation of the embodiment of the present invention three is once taken, three times a day, warm water delivery service, 3
Month 1 course for the treatment of.
Treat four groups：The capsule 5 of the preparation of the embodiment of the present invention four is once taken, three times a day, warm water delivery service, 3
Month 1 course for the treatment of.
Treat five groups：The capsule 5 of the preparation of the embodiment of the present invention five is once taken, three times a day, warm water delivery service, 3
Month 1 course for the treatment of.
Control group：The capsule 5 of reference examples is once taken, three times a day, warm water delivery service, 3 months 1 courses for the treatment of.
Pass through following observation of curative effect：1st, sign symptom；2nd, B ultrasound：Its fibroid size variation is observed, calculates its maximum diameter
Product (M=transverse diameters * indulges footpath).
Treat one group:Cure 5 (33.3%), effective 4 (26.7%), effective 4 (26.7%), invalid 2
(13.3%)；
Treat two groups:Cure 8 (53.3%), effective 4 (26.7%), effective 3 (20.0%), invalid 0
(0%)；
Treat three groups：Cure 6 (40.0%), effective 5 (33.3%), effective 3 (20.0%), invalid 1
(6.6%)；
Treat four groups：Cure 6 (40.0%), effective 4 (26.7%), effective 4 (26.7%), invalid 1
(6.6%)；
Treat five groups：Cure 5 (33.3%), effective 5 (33.3%), effective 4 (26.7%), invalid 1
(6.6%)；
Control group：Cure 2 (13.3%), effective 3 (20.0%), effective 3 (20.0%), invalid 6
(40.0%).
It can determine whether by clinical effectiveness, capsule prepared by a kind of Chinese medicine composition for treating fibroid of the invention is used for
Treat fibroid 3 months, cure rate is up to 33%, and for high efficiency up to 90%, curative effect is better than control group, and the glue of embodiment two
Capsule curative effect is optimal.
In a further embodiment, a kind of Chinese medicine composition for treating fibroid of the invention can also pass through conventional side
Method is prepared into the preparations such as decoction of medicinal ingredients, oral liquid, particle, is respectively provided with good fibroid therapeutic effect.
In conclusion using a kind of Chinese medicine composition for treating fibroid provided by the present invention, fibroid is cured
Significant effect, curative effect are fast.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
God and any modification, equivalent substitution, improvement and etc. within principle, done, should be included within the scope of protection of the invention.
Claims (4)
- A kind of 1. Chinese medicine composition for treating fibroid, it is characterised in that：The Chinese medicine composition by following parts by weight group Divide and form：100-180 parts of Poria cocos, 70-120 parts of cattail pollens, 5-15 portions of pseudo-ginseng, 80-120 parts of cassia twig, 30-70 parts of safflowers, 80-130 Part radix cyathulae, 75-115 parts of Radix Salviae Miltiorrhizaes, the 80-125 parts of radix paeoniae rubrathe, 80-110 portions of motherworts, 80-110 parts of peach kernels, 120-160 parts of ink droughts Lotus and 80-120 parts of Herba Lycopi.
- A kind of 2. Chinese medicine composition for treating fibroid according to claim 1, it is characterised in that：The Chinese traditional medicine composition Thing is made of the component of following parts by weight：150 parts of Poria cocos, 100 parts of cattail pollens, 10 portions of pseudo-ginseng, 100 parts of cassia twig, 50 parts of safflowers, 100 Part radix cyathulae, 100 parts of Radix Salviae Miltiorrhizaes, 100 parts of radix paeoniae rubrathe, 100 portions of motherworts, 100 parts of peach kernels, 150 portions of ecliptas and 100 parts of Herba Lycopi.
- A kind of 3. preparation for treating fibroid, it is characterised in that：The active ingredient of the preparation is described in claim 1 or 2 A kind of Chinese medicine composition for treating fibroid.
- A kind of 4. preparation for treating fibroid according to claim 3, it is characterised in that：The preparation for capsule, One kind in grain or oral liquid.
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| Title |
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| 宫肌瘤消胶囊联合子宫动脉栓塞治疗子宫肌瘤的临床研究;林海珍;《硕士学位论文》;20110928;第21-22页，尤其是第21页第2段 * |
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