CN105169330A - Traditional Chinese medicine preparation for treating dysmenorrhea - Google Patents
Traditional Chinese medicine preparation for treating dysmenorrhea Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation for treating dysmenorrhea. The traditional Chinese medicine preparation is prepared from medicinal materials as follows: marsdenia tinctoria, ginger leaves, herb of cochinchina centranthera, motherwort fruits, kadsura root-bark, rhizomes of featherleaf rodgersflower, fructus litseae, dutchmanspipe vine, ivy glorybind rhizomes, giant st.john's wort, gynura japonica, silkworm shit, acer mono maxim., fruits of combined spicebush, fructus litseae, burmann cinnamon barks, notholirion hyacinthinum (Wils.) stapf, herb of stickyhair pearleverlasting, citron fruit, oblongleaf kadsura stems or roots, caulis polygoni multiflori, holothuria nobilis(Selenka), flastem milkvetch seeds, fructus polygoni orientalis and cucubalus roots. The traditional Chinese medicine preparation has the efficacy of activation of blood circulation, removal of blood stasis, promotion of qi circulation, relief of pains, meridian warming, coldness removal, blood nourishment and kidney tonification.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of dysmenorrhea, belong to the field of Chinese medicines.
Background technology
Dysmenorrhea refers to gynecologic menstrual or front and back of passing through, and periodically occurs lower abdomen spasmic pain, or falling inflation sense, or pain draws waist sacrum, and with the symptom such as Nausea and vomiting, cold extremities time serious, even severe pain is fainted, and belongs to motherland's medical science " abdominal pain during menstruation " category.2 large classes can be divided into clinically: a class is that the dysmenorrhea caused by the clear and definite disease of genitals is called secondary dysmenorrhea; One class is the primary dysmenorrhea of genitals without significant organic pathological changes.According to the literature, in global women, 80% has dysmenorrhea in various degree, and wherein about 3/4 affects work, and main generation colony is adolescent girls and young woman that is unmarried or that do not educate.This disease of dysmenorrhea has had a strong impact on the quality of life of patient.
Motherland's medical science is thought, the sick position of dysmenorrhea is appointed in punching, uterus, dirty closely related with kidney,spleen,liver three, changes in QI and blood, shows as pain disease." stagnation of QI and blood may bring about pain ", " not Rong Ze pain " are the Etiological pathogenesis causing dysmenorrhea to occur." stagnation of QI and blood may bring about pain " has volt in excess pathogen, how owing to feeling depressed or excessive anger impairing the liver, and stagnation of QI due to depression of the liver, qi depression to blood stasis; Or on the occasion of puerperal in menstrual period, experience cold-evil, eating cold and uncooked food excessively, cold visitor's punching is appointed, and fights and ties, cause coagulation of QI-blood with blood; Or experience damp and hot heresy, heat and blood are fought, so that stagnation of QI-blood is not smooth; " not Rong Ze pain " is because uterus loses in moistening foster, or due to congenital deficiency of kidney-QI; Or prolonged illness, exhaustion due to sexual indulgence, fecund, deficiency of kidney essence insufficiency of blood; Or ferritic insufficiency of vital energy and blood; Or weakness of the spleen and stomach, change source not enough, when passing through, QI and blood virtual loss is more appointed in punching, and vessels of the uterus loses supports and makes dysmenorrhea.Dysmenorrhea is the large class of deficiency and excess two clinically, and excess syndrome mostly is qi depression to blood stasis, cold and stagnate, dampness and heat stasis; Deficiency syndrome mostly are deficient qi and blood, deficient two types of Liver and kidney.
Doctor trained in Western medicine many employings NSAID (non-steroidal anti-inflammatory drug), spasmolytic tranquilizer, receptor agonism agent medicine are treated, though can respite pain, late result be unsatisfactory, and have dyspepsia, nauseating, heartburn, diarrhoea, constipation, headache, dizziness, the side effect such as drowsiness.If these medicines of life-time service, women's endocrine can be caused to lack of proper care.And Chinese medicine dysmenorrhea has unique advantage, and have clinical efficacy significantly and side effect less.
Summary of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of dysmenorrhea.Chinese medicine preparation of the present invention can be eliminated or relieving dysmenorrhea symptom, plays treating both the principal and secondary aspects of a disease effect.It has determined curative effect, advantage that toxic and side effects is little.
Present inventor is through clinical experience for many years, and research is groped repeatedly, by the checking of clinical trial, finally have found the Chinese medicinal components proportioning of determined curative effect, thus completes the present invention.
Side's medicine of the present invention selects Caulis Marsdeniae tinctoriae, Folium Zingiberis, Herba Centrantherae Cochinchinensis blood circulation promoting and dispersing pathogen accumulation, and blood-activating analgetic, can be monarch drug.Fructus Leonuri, Cortex cercis chinensis, Rhizoma Rodgersiae, Cortex fici lacoris promoting blood flow to regulate menstruation, four medicines match, and are ministerial drug, all the other Herba Aristolochiaes, and all medicines of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) are adjuvant, wherein select Herba Aristolochiae, energy promoting flow of QI and blood; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Hyperici, can invigorating spleen to remove dampness, promoting blood flow to regulate menstruation.Be equipped with Radix Gynurae, Five Dragons skin, Bombyx mori L., analgesic therapy effect of invigorating blood circulation in reinforcement side; Be equipped with Fructus Linderae, Fructus Litseae again, Cortex Cinnamomi Burmannii can warming spleen and stomach for dispelling cold; Select again with Bullus Notholirionis Bulbuliferi, Herba Clematidis Meyenianae, Fructus Citri, Caulis Seu Radix Kadsurae Oblongifoliae, can promoting the circulation of QI to relieve pain; Caulis Polygoni Multiflori, Wu Nican, Semen Astragali Complanati, Fructus Polygoni Orientalis, Radix Cucubali is added again in rearmost, can nourishing the liver and kidney, nourishing blood for regulating menstruation.All medicines are harmonious, and make full side have blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, dispelling cold by warming the meridian, effect of blood rearing interpolating kidney.Originally can effectively treat dysmenorrhea disease, play treating both the principal and secondary aspects of a disease object.
Source and the efficacy effect of Chinese medicine of the present invention are as follows: wherein,
Caulis Marsdeniae tinctoriae: be asclepiadaceae Caulis Marsdeniae tinctoriae MarsdeniatinctoriaR.Brown, is used as medicine with fruit.Nature and flavor, pungent, bitter, warm in nature.Effect: expelling wind and removing dampness; Blood stasis-eliminating and stagnation-dissipating.
Folium Zingiberis: be the stem and leaf of zingiber ZingiberofficinaleRosc.Nature and flavor, pungent, warm in nature.Effect: blood circulation promoting and dispersing pathogen accumulation.
Herba Centrantherae Cochinchinensis: be the herb of goatweed Herba Centrantherae Cochinchinensis Centrantheracochinchinensis.Nature and flavor, warm in nature, sour in the mouth, micro-fiber crops.Effect: detumescence dissipating blood stasis, hemostasis and pain-relieving.
Fructus Leonuri: be the dry mature fruit of labiate Herba Leonuri LeonurusjaponicusHoutt..Property, acrid in the mouth, hardship, be slightly cold.Effect: promoting blood flow to regulate menstruation, liver heat removing and eyesight improving.
Cortex cercis chinensis: be the bark of Magnoliaceae Kadsura Fructus Schisandrae Sphenantherae KadsuralongepedunculataFin.etGagnep.Property, bitter in the mouth is flat.Effect: promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, removing toxic substances.
Rhizoma Rodgersiae: be Saxifragaceae Rodgersia podophylla A. Gray platymiscium southwest Rodgersia podophylla A. Gray RodgersiasambucifoliaHemsl., be used as medicine with root stock and root.Nature and flavor are bitter, puckery, cool.Effect: clearing away heat and cooling blood, menstruction regulating and pain relieving.
Cortex fici lacoris: be the bark of the yellow Ge Shu of moraceae plants.Nature and flavor are bitter; Acid; Warm in nature.Effect: dispelling wind and removing obstruction in the collateral; Killing parasites for relieving itching.
Herba Aristolochiae: be the dry aerial parts of aristolochiaceae plant Fructus Aristolochiae AristolochiadebilisSieb.etZucc..Nature and flavor, bitter, temperature.Effect: promoting flow of QI and blood, inducing diuresis to remove edema.
Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae): be herb or the root of dicotyledon scammonia section plant DAWANHUA CalystegiahederaceaWall.Nature and flavor, sweet micro-hardship, flat.Effect: invigorating spleen to remove dampness, regulating menstruation.
Herba Hyperici: be Hypericaceae hypericum Herba Hyperici HypericumascyronL., with all herbal medicine.Nature and flavor are bitter, cold.Effect: cooling blood for hemostasis, heat-clearing and toxic substances removing
Radix Gynurae: be leaf or the herb of feverfew Radix Gynurae.Nature and flavor, sweet, flat.Effect: promoting blood circulation and hemostasis, removing toxic substances.
Bombyx mori L.: be the dry feces of Bombycidae animal bombyx mori larva BombyxmoriL.Nature and flavor, sweet in the mouth; Pungent; Warm in nature.Effect: expelling wind and removing dampness; Regulating the function of the stomach to resolve the turbidity; Promoting blood circulation to restore menstrual flow.
Five Dragons skin: Aceraceae Five Dragons skin AcermonoMaxim, is used as medicine with branch, leaf.Nature and flavor, pungent, temperature.Effect: expelling wind and removing dampness, blood circulation and removing stasis.
Fructus Linderae: be the fruit of canella Radix Linderae Linderaaggregata.Nature and flavor, pungent, temperature.Effect: cold expelling recuperating depleted YANG; Warming middle-JIAO for easing the stomach.
Fructus Litseae: be the dry mature fruit of canella cubeb litsen tree Litseacubeba (Lour.) Pers..Nature and flavor, pungent, temperature.Effect: warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain
Cortex Cinnamomi Burmannii: be the bark of the cloudy fragrant Cinnamomumburmannii of canella.Nature and flavor, pungent, micro-sweet, warm in nature.Effect: warming spleen and stomach for dispelling cold, wind-damp dispelling.
Bullus Notholirionis Bulbuliferi: for Liliaceae Bulbus Notholirionis hyacinthini platymiscium Bulbus Notholirionis hyacinthini NotholirionhyacinthinumStapf is used as medicine with clove.Nature and flavor, pungent, temperature.Effect: the chest stuffiness relieving is regulated the flow of vital energy, cough-relieving pain relieving.
Herba Clematidis Meyenianae: the peaceful MoslasoochouensisMatsuda of Labiatae shepherd's purse peaceful platymiscium Suzhou shepherd's purse, with ground all herbal medicine.Nature and flavor, pungent, temperature.Effect: detoxicating, relieving inflammation, promoting diuresis and easing pain.
Fructus Citri: be the dry mature fruit of rutaceae citron CitrusmedicaL..Nature and flavor, pungent, bitter, sour, temperature.Effect: liver-smoothing, qi-regulating, alleviating distention in middle-JIAO, reduces phlegm.
Caulis Seu Radix Kadsurae Oblongifoliae: be rattan or the root of Schisandraceae Plant cold meal rattan KadsuraoblongifoliaMerr.Nature and flavor, sweet, temperature.Effect: expelling wind and removing dampness, promoting the circulation of QI to relieve pain.
Caulis Polygoni Multiflori: be the dry rattan of polygonum multiflorum thunb PolygonummultiflorumThunb..Nature and flavor, sweet, flat.Effect: nourishing blood to tranquillize the mind, dispelling wind and removing obstruction in the collateral.
Wu Nican: be the entirety of Holothuriidae animal Holothuria nobilis Selenka Holothurianobilis.Nature and flavor, sweet, salty, temperature.Effect: the kidney invigorating, YIN nourishing, lactogenesis.
Semen Astragali Complanati: be the seed of leguminous plant astragatus complanatus or Seem Astragali.Nature and flavor, sweet, temperature.Effect: temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.
Fructus Polygoni Orientalis: be the dry mature fruit of polygonaceae plant smartweed PolygonumorientaleL..Nature and flavor, salty, be slightly cold.Effect: loose blood eliminating mass, removing food stagnancy pain relieving.
Radix Cucubali: be root or the herb of pinkwort Brachystemma calycina D. Don. BrachystemmacalycinuD.Don.Nature and flavor, sweet, bitter, property is put down.Effect: blood circulation promoting and blood stasis dispelling, treating stranguria let out turbid, removing toxic substances and promoting subsidence of swelling.
The object of the present invention is achieved like this, the present invention treats the Chinese medicine preparation of dysmenorrhea, it is be made up of the raw material of following weight portion: Caulis Marsdeniae tinctoriae 80 ~ 100 parts, Folium Zingiberis 50 ~ 70 parts, Herba Centrantherae Cochinchinensis 50 ~ 70 parts, Fructus Leonuri 50 ~ 70 parts, Cortex cercis chinensis 40 ~ 60 parts, Rhizoma Rodgersiae 40 ~ 60 parts, Cortex fici lacoris 40 ~ 60 parts, Herba Aristolochiae 20 ~ 40 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 20 ~ 40 parts, Herba Hyperici 20 ~ 40 parts, Radix Gynurae 20 ~ 40 parts, Bombyx mori L. 10 ~ 30 parts, Five Dragons skin 30 ~ 50 parts, Fructus Linderae 30 ~ 50 parts, Fructus Litseae 20 ~ 40 parts, Cortex Cinnamomi Burmannii 30 ~ 50 parts, Bullus Notholirionis Bulbuliferi 30 ~ 50 parts, Herba Clematidis Meyenianae 10 ~ 30 parts, Fructus Citri 30 ~ 50 parts, Caulis Seu Radix Kadsurae Oblongifoliae 30 ~ 50 parts, Caulis Polygoni Multiflori 30 ~ 50 parts, crow Buddhist nun joins 20 ~ 40 parts, Semen Astragali Complanati 10 ~ 30 parts, Fructus Polygoni Orientalis 20 ~ 40 parts, Radix Cucubali 20 ~ 40 parts.
Preferred as Chinese medicine preparation of the present invention, be made up of the raw material of following weight portion: Caulis Marsdeniae tinctoriae 90 parts, Folium Zingiberis 60 parts, Herba Centrantherae Cochinchinensis 60 parts, Fructus Leonuri 60 parts, Cortex cercis chinensis 50 parts, Rhizoma Rodgersiae 50 parts, Cortex fici lacoris 50 parts, Herba Aristolochiae 30 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 30 parts, Herba Hyperici 30 parts, Radix Gynurae 30 parts, Bombyx mori L. 20 parts, Five Dragons skin 40 parts, Fructus Linderae 40 parts, Fructus Litseae 30 parts, Cortex Cinnamomi Burmannii 40 parts, Bullus Notholirionis Bulbuliferi 40 parts, Herba Clematidis Meyenianae 20 parts, Fructus Citri 40 parts, Caulis Seu Radix Kadsurae Oblongifoliae 40 parts, Caulis Polygoni Multiflori 40 parts, black Buddhist nun join 30 parts, Semen Astragali Complanati 20 parts, Fructus Polygoni Orientalis 30 parts, Radix Cucubali 30 parts.
Preferred as Chinese medicine preparation of the present invention, be made up of the raw material of following weight portion: Caulis Marsdeniae tinctoriae 80 parts, Folium Zingiberis 50 parts, Herba Centrantherae Cochinchinensis 70 parts, Fructus Leonuri 50 parts, Cortex cercis chinensis 40 parts, Rhizoma Rodgersiae 60 parts, Cortex fici lacoris 60 parts, Herba Aristolochiae 40 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 20 parts, Herba Hyperici 20 parts, Radix Gynurae 40 parts, Bombyx mori L. 30 parts, Five Dragons skin 30 parts, Fructus Linderae 50 parts, Fructus Litseae 20 parts, Cortex Cinnamomi Burmannii 50 parts, Bullus Notholirionis Bulbuliferi 30 parts, Herba Clematidis Meyenianae 10 parts, Fructus Citri 30 parts, Caulis Seu Radix Kadsurae Oblongifoliae 50 parts, Caulis Polygoni Multiflori 50 parts, black Buddhist nun join 40 parts, Semen Astragali Complanati 10 parts, Fructus Polygoni Orientalis 40 parts, Radix Cucubali 20 parts.
Preferred as Chinese medicine preparation of the present invention, be made up of the raw material of following weight portion: Caulis Marsdeniae tinctoriae 100 parts, Folium Zingiberis 70 parts, Herba Centrantherae Cochinchinensis 50 parts, Fructus Leonuri 70 parts, Cortex cercis chinensis 60 parts, Rhizoma Rodgersiae 40 parts, Cortex fici lacoris 40 parts, Herba Aristolochiae 20 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 40 parts, Herba Hyperici 40 parts, Radix Gynurae 20 parts, Bombyx mori L. 10 parts, Five Dragons skin 50 parts, Fructus Linderae 30 parts, Fructus Litseae 40 parts, Cortex Cinnamomi Burmannii 30 parts, Bullus Notholirionis Bulbuliferi 50 parts, Herba Clematidis Meyenianae 30 parts, Fructus Citri 50 parts, Caulis Seu Radix Kadsurae Oblongifoliae 30 parts, Caulis Polygoni Multiflori 30 parts, black Buddhist nun join 20 parts, Semen Astragali Complanati 30 parts, Fructus Polygoni Orientalis 20 parts, Radix Cucubali 40 parts.
The preparation method of Chinese medicine preparation of the present invention, is made up of following steps:
(1) Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Cortex fici lacoris, excrementum bombycis meal are broken into fine powder;
(2) get Caulis Polygoni Multiflori, Fructus Leonuri, Fructus Citri medical material, adding medical material weight ratio is 8 ~ 10 times amount 50 ~ 70% ethanol, heating and refluxing extraction 2 times, each 0.5 ~ 2h, filter, merging filtrate also reclaims ethanol extremely without after alcohol taste, concentrate drying, and be ground into dried cream powder, sieve, medicinal residues are for subsequent use;
(3) step medicinal residues are (2) merged with Caulis Marsdeniae tinctoriae, Folium Zingiberis, Herba Centrantherae Cochinchinensis, Cortex cercis chinensis, Rhizoma Rodgersiae, Herba Aristolochiae, Herba Hyperici, Radix Gynurae, Five Dragons skin, Fructus Linderae, Fructus Litseae, Cortex Cinnamomi Burmannii, Bullus Notholirionis Bulbuliferi, Herba Clematidis Meyenianae, Caulis Seu Radix Kadsurae Oblongifoliae, Wu Nican, Semen Astragali Complanati, Fructus Polygoni Orientalis, Radix Cucubali medical material again, adding with medical material weight ratio is the soak by water 1 ~ 3 time of 9 ~ 11 times amount, each 0.5 ~ 2h, filter, merging filtrate, concentrating under reduced pressure is dry, and is ground into dried cream powder, for subsequent use;
(4) get above-mentioned steps (1) in fine powder, step (2), (3) in dried cream powder, after mixing, obtain Traditional Chinese drug mixture, then to add on pharmaceutics conventional adjuvant and make various different oral formulations, to obtain final product.
Preferably, the preparation method of Chinese medicine preparation of the present invention, is made up of following steps:
(1) Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Cortex fici lacoris, excrementum bombycis meal are broken into fine powder;
(2) get Caulis Polygoni Multiflori, Fructus Leonuri, Fructus Citri medical material, adding medical material weight ratio is 9 times amount 60% ethanol, heating and refluxing extraction 2 times, each 1h, filters, and merging filtrate also reclaims ethanol extremely without after alcohol taste, concentrate drying, and is ground into dried cream powder, and sieve, medicinal residues are for subsequent use;
(3) step medicinal residues are (2) merged with Caulis Marsdeniae tinctoriae, Folium Zingiberis, Herba Centrantherae Cochinchinensis, Cortex cercis chinensis, Rhizoma Rodgersiae, Herba Aristolochiae, Herba Hyperici, Radix Gynurae, Five Dragons skin, Fructus Linderae, Fructus Litseae, Cortex Cinnamomi Burmannii, Bullus Notholirionis Bulbuliferi, Herba Clematidis Meyenianae, Caulis Seu Radix Kadsurae Oblongifoliae, Wu Nican, Semen Astragali Complanati, Fructus Polygoni Orientalis, Radix Cucubali medical material again, adding with medical material weight ratio is the soak by water 2 times of 10 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure is dry, and is ground into dried cream powder, for subsequent use;
(4) get above-mentioned steps (1) in fine powder, step (2), (3) in dried cream powder, after mixing, obtain Traditional Chinese drug mixture, then to add on pharmaceutics conventional adjuvant and make various different oral formulations, to obtain final product.
The dosage form of Chinese medicine preparation of the present invention is that peroral dosage form comprises: capsule, tablet, granule.
The dosage form of Chinese medicine preparation of the present invention is preferably capsule.
The beneficial effect that Chinese medicine preparation of the present invention has is: each crude drug component in Chinese medicine preparation of the present invention and proportioning thereof, gropes out through differential diagnosis in tcm compatibility and clinical empirical summary.Its each medical material compatibility complements each other using, and has synergism.QI and blood is in harmonious proportion, and menses are smooth, and the two makes punching appoint unimpeded and prevent or eliminate the gesture of uterus paralysis resistance, thus reaches the object of " general rule is not bitterly ".Also full side is made to have blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, dispelling cold by warming the meridian, effect of blood rearing interpolating kidney, to adapt to the treatment requirement of the complicated state of an illness.
Compared with prior art, Chinese medicine preparation of the present invention has evident in efficacy, and toxic and side effects is little, the advantage that relapse rate is low.Chinese medicine preparation of the present invention can improve microcirculation disturbance in patient body, prostaglandin excretion level in balance endometrium.Through clinical verification, the effective percentage of the clinical cure of Chinese medicine preparation of the present invention is up to 95.7%, and all cases all have no adverse reaction.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
(1), by Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 30g, Cortex fici lacoris 50g, Bombyx mori L. 20g, be ground into fine powder;
(2) get Caulis Polygoni Multiflori 40g, Fructus Leonuri 60g, Fructus Citri 40g, adding medical material weight ratio is 9 times amount 60% ethanol, heating and refluxing extraction 2 times, each 1h, filter, merging filtrate also reclaims ethanol extremely without after alcohol taste, concentrate drying, and be ground into dried cream powder, sieve, medicinal residues are for subsequent use;
(3) step medicinal residues are (2) joined 30g, Semen Astragali Complanati 20g, Fructus Polygoni Orientalis 30g, Radix Cucubali 30g with Caulis Marsdeniae tinctoriae 90g, Folium Zingiberis 60g, Herba Centrantherae Cochinchinensis 60g, Cortex cercis chinensis 50g, Rhizoma Rodgersiae 50g, Herba Aristolochiae 30g, Herba Hyperici 30g, Radix Gynurae 30g, Five Dragons skin 40g, Fructus Linderae 40g, Fructus Litseae 30g, Cortex Cinnamomi Burmannii 40g, Bullus Notholirionis Bulbuliferi 40g, Herba Clematidis Meyenianae 20g, Caulis Seu Radix Kadsurae Oblongifoliae 40g, black Buddhist nun again, adding with medical material weight ratio is the soak by water 3 times of 9 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure is dry, and be ground into dried cream powder, for subsequent use;
(4) get above-mentioned steps (1) in fine powder, step (2), (3) in dried cream powder, after mixing fully after mixing, add suitable adjuvant, granulate, encapsulated, make hard capsule.
Embodiment 2
(1), by Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 20g, Cortex fici lacoris 60g, Bombyx mori L. 30g, be ground into fine powder;
(2) get Caulis Polygoni Multiflori 50g, Fructus Leonuri 50g, Fructus Citri 30g, adding medical material weight ratio is 8 times amount 70% ethanol, heating and refluxing extraction 2 times, each 2h, filter, merging filtrate also reclaims ethanol extremely without after alcohol taste, concentrate drying, and be ground into dried cream powder, sieve, medicinal residues are for subsequent use;
(3) step medicinal residues are (2) joined 40g, Semen Astragali Complanati 10g, Fructus Polygoni Orientalis 40g, Radix Cucubali 20g with Caulis Marsdeniae tinctoriae 80g, Folium Zingiberis 50g, Herba Centrantherae Cochinchinensis 70g, Cortex cercis chinensis 40g, Rhizoma Rodgersiae 60g, Herba Aristolochiae 40g, Herba Hyperici 20g, Radix Gynurae 40g, Five Dragons skin 30g, Fructus Linderae 50g, Fructus Litseae 20g, Cortex Cinnamomi Burmannii 50g, Bullus Notholirionis Bulbuliferi 30g, Herba Clematidis Meyenianae 10g, Caulis Seu Radix Kadsurae Oblongifoliae 50g, black Buddhist nun again, adding with medical material weight ratio is the soak by water 2 times of 10 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure is dry, and be ground into dried cream powder, for subsequent use;
(4) get above-mentioned steps (1) in fine powder, step (2), (3) in dried cream powder, with appropriate dextrin, sucrose after mixing, mixing, granulates, dry, makes granule.
Embodiment 3
(1), by Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 40g, Cortex fici lacoris 40g, Bombyx mori L. 10g, be ground into fine powder;
(2) get Caulis Polygoni Multiflori 30g, Fructus Leonuri 70g, Fructus Citri 50g, adding medical material weight ratio is 10 times amount 50% ethanol, heating and refluxing extraction 2 times, each 0.5h, filter, merging filtrate also reclaims ethanol extremely without after alcohol taste, concentrate drying, and be ground into dried cream powder, sieve, medicinal residues are for subsequent use;
By step medicinal residues (2) again with Caulis Marsdeniae tinctoriae 100g, Folium Zingiberis 70g, Herba Centrantherae Cochinchinensis 50g, Cortex cercis chinensis 60g, Rhizoma Rodgersiae 40g, Herba Aristolochiae 20g, Herba Hyperici 40g, Radix Gynurae 20g, Five Dragons skin 50g, Fructus Linderae 30g, Fructus Litseae 40g, Cortex Cinnamomi Burmannii 30g, Bullus Notholirionis Bulbuliferi 50g, Herba Clematidis Meyenianae 30g, Caulis Seu Radix Kadsurae Oblongifoliae 30g, black Buddhist nun join 20g, Semen Astragali Complanati 30g, Fructus Polygoni Orientalis 20g, Radix Cucubali 40g, adding with medical material weight ratio is the soak by water 1 time of 11 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure is dry, and be ground into dried cream powder, for subsequent use;
(4) get above-mentioned steps (1) in fine powder, step (2), (3) in dried cream powder, after mixing, obtain Traditional Chinese drug mixture, mix with appropriate amount of starch, dextrin, granulate, be pressed into tablet.
In order to verify the curative effect of Chinese medicine preparation of the present invention further, the Chinese medicine preparation of preparation in above-mentioned specific embodiment 1 has been carried out corresponding clinical trial by us, existing that report the test is as follows.
The clinical observation to dysmenorrhea of Chinese medicine preparation of the present invention
1. physical data
Accept dysmenorrhea patient totally 132 examples for medical treatment, after obtaining patient's agreement, be divided into treatment group 69 example and matched group 63 example at random.18 ~ 42 years old treatment group age, year mean age (29.3 ± 2.5), the course of disease 3 months ~ 3 years, average course of disease (1.9 ± 0.6) year; Matched group, 17 ~ 39 years old age, year mean age (27.9 ± 2.3), the course of disease 5 months ~ 4 years, average course of disease (2.4 ± 0.8) year, through statistical procedures no significant difference (P > 0.05) between two groups of patient ages, the course of disease, severity extent, there is comparability.
2. diagnostic criteria
Patient all meets " new Chinese medicine guideline of clinical investigations " and " doctor trained in Western medicine obstetrics and gynecology " clinical criteria, specific as follows: 1. to occur the symptom such as hypogastralgia, falling inflation before and after patient menstrual, affects minimal invasive treatment and work.2. patient carries out gynecological's coherence check and ultrasound diagnosis without detailed organic disease.3. patient age was at 18 years old ~ 42 years old.4. patient does not receive other treatment before treatment.
3. Therapeutic Method
Matched group: give TIANQI TONGJING JIAONANG (Lijing pharmaceutcal corporation, Ltd of YUNNAN BAIYAO group) oral medication, menstrual period or premenstrual 5 days one time 3,3 times on the one 2 weeks is a course for the treatment of, serve on 3 courses for the treatment of.
Treatment group: according to the method for the embodiment of the present invention 1 group, obtained Chinese medicine capsules, oral, menstrual period or premenstrual 5 days one time 3,3 times on the one 2 weeks is a course for the treatment of, serve on 3 courses for the treatment of, evaluates its curative effect.
4. efficacy assessment standard
Recovery from illness: patient's dysmenorrhea clinical symptoms disappears completely, and menstruation can arrive on time.Effective: the clinical symptoms such as patient's dysmenorrhea make moderate progress, and patient menstrual does not arrive once in a while on time.Effective: the symptoms such as patient's dysmenorrhea, hypogastralgia are taken a turn for the better, and needs of patients is lain up and faced.Invalid: patients symptomatic does not change or occurs adding reconstructed image.
5. therapeutic outcome
Table 1 liang group patient clinical comparitive study
From the experimental result of table 1, the total effective rate for the treatment of group of the present invention is 95.7%, and the patient's effective percentage taking matched group (TIANQI TONGJING JIAONANG) is 76.2%.Result shows, the clinical efficacy of Chinese medicine preparation of the present invention in treatment dysmenorrhea is remarkable, is obviously better than matched group.And in therapeutic process, do not find any untoward reaction.And in the patient of clinical cure, leave hospital latter 6 months, pay a return visit, treatment group also finds no the situation of recurrence.This illustrates, Chinese medicine Chinese medicine preparation of the present invention treats determined curative effect in dysmenorrhea disease in preparation, remarkable, relapse rate is low, and clinic is applied.
6. model case
Case 1, Tang, female, 22 years old, suffers from dysmenorrhea more than 1 year, and before medical, namely patient suffers from dysmenorrhea from menarche, abdominal pain in menstruation, feels sick, and myasthenia of limbs, cold perspiration, fear of cold of being afraid of cold, has a strong impact on study, and once carried out multiple treatment, effect is bad.After take after capsule of the present invention carries out 1 course for the treatment of of treatment, patients symptomatic obviously alleviates, and continues to take 2 courses for the treatment of, and patient clinical symptom and stomachache disappear, and cure.Follow up a case by regular visits to and have no recurrence half a year.
Case 2, model, female, 28 years old, patient suffered from dysmenorrhea more than 3 years.Namely be dysmenorrhea after menstrual onset, unbearably, even need to take analgesic, menstruation color secretly holds block under the arm to each menstrual pain.Through gynecologial examination, after getting rid of the mechanical injuries of reproductive system organs in pelvic cavity, after patient takes 3 courses for the treatment of of capsule of the present invention, the eumenorrhea, pain disappears, and follows up a case by regular visits to and have no recurrence after half a year.
Case 3, Wu, female, 38 years old, dysmenorrhea was more than 2 years.Patient per's lower abdomen in menstrual period pain, Hypomenorrhea, dark through color, have clot, distention and pain of breast before menstruation, stringy and thready pulse, the dark tongue of light red tongue is white, and yellowish urine, defecates partially dry.Patient is irascible temperament usually, and before passing through, temper is large at every turn, easily irritated, irritability.After patient takes 3 courses for the treatment of of Chinese medicine capsules of the present invention, when passing through, stomachache disappears, and follows up a case by regular visits to and have no recurrence after half a year.
Claims (9)
1. treat the Chinese medicine preparation of dysmenorrhea for one kind, it is characterized in that, its raw material primarily of following weight portion is made: Caulis Marsdeniae tinctoriae 80 ~ 100 parts, Folium Zingiberis 50 ~ 70 parts, Herba Centrantherae Cochinchinensis 50 ~ 70 parts, Fructus Leonuri 50 ~ 70 parts, Cortex cercis chinensis 40 ~ 60 parts, Rhizoma Rodgersiae 40 ~ 60 parts, Cortex fici lacoris 40 ~ 60 parts, Herba Aristolochiae 20 ~ 40 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 20 ~ 40 parts, Herba Hyperici 20 ~ 40 parts, Radix Gynurae 20 ~ 40 parts, Bombyx mori L. 10 ~ 30 parts, Five Dragons skin 30 ~ 50 parts, Fructus Linderae 30 ~ 50 parts, Fructus Litseae 20 ~ 40 parts, Cortex Cinnamomi Burmannii 30 ~ 50 parts, Bullus Notholirionis Bulbuliferi 30 ~ 50 parts, Herba Clematidis Meyenianae 10 ~ 30 parts, Fructus Citri 30 ~ 50 parts, Caulis Seu Radix Kadsurae Oblongifoliae 30 ~ 50 parts, Caulis Polygoni Multiflori 30 ~ 50 parts, crow Buddhist nun joins 20 ~ 40 parts, Semen Astragali Complanati 10 ~ 30 parts, Fructus Polygoni Orientalis 20 ~ 40 parts, Radix Cucubali 20 ~ 40 parts.
2. treat the Chinese medicine preparation of dysmenorrhea as claimed in claim 1, it is characterized in that, its raw material primarily of following weight portion is made: Caulis Marsdeniae tinctoriae 90 parts, Folium Zingiberis 60 parts, Herba Centrantherae Cochinchinensis 60 parts, Fructus Leonuri 60 parts, Cortex cercis chinensis 50 parts, Rhizoma Rodgersiae 50 parts, Cortex fici lacoris 50 parts, Herba Aristolochiae 30 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 30 parts, Herba Hyperici 30 parts, Radix Gynurae 30 parts, Bombyx mori L. 20 parts, Five Dragons skin 40 parts, Fructus Linderae 40 parts, Fructus Litseae 30 parts, Cortex Cinnamomi Burmannii 40 parts, Bullus Notholirionis Bulbuliferi 40 parts, Herba Clematidis Meyenianae 20 parts, Fructus Citri 40 parts, Caulis Seu Radix Kadsurae Oblongifoliae 40 parts, Caulis Polygoni Multiflori 40 parts, crow Buddhist nun joins 30 parts, Semen Astragali Complanati 20 parts, Fructus Polygoni Orientalis 30 parts, Radix Cucubali 30 parts.
3. treat the Chinese medicine preparation of dysmenorrhea as claimed in claim 1, it is characterized in that, its raw material primarily of following weight portion is made: Caulis Marsdeniae tinctoriae 80 parts, Folium Zingiberis 50 parts, Herba Centrantherae Cochinchinensis 70 parts, Fructus Leonuri 50 parts, Cortex cercis chinensis 40 parts, Rhizoma Rodgersiae 60 parts, Cortex fici lacoris 60 parts, Herba Aristolochiae 40 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 20 parts, Herba Hyperici 20 parts, Radix Gynurae 40 parts, Bombyx mori L. 30 parts, Five Dragons skin 30 parts, Fructus Linderae 50 parts, Fructus Litseae 20 parts, Cortex Cinnamomi Burmannii 50 parts, Bullus Notholirionis Bulbuliferi 30 parts, Herba Clematidis Meyenianae 10 parts, Fructus Citri 30 parts, Caulis Seu Radix Kadsurae Oblongifoliae 50 parts, Caulis Polygoni Multiflori 50 parts, crow Buddhist nun joins 40 parts, Semen Astragali Complanati 10 parts, Fructus Polygoni Orientalis 40 parts, Radix Cucubali 20 parts.
4. treat the Chinese medicine preparation of dysmenorrhea as claimed in claim 1, it is characterized in that, its raw material primarily of following weight portion is made: Caulis Marsdeniae tinctoriae 100 parts, Folium Zingiberis 70 parts, Herba Centrantherae Cochinchinensis 50 parts, Fructus Leonuri 70 parts, Cortex cercis chinensis 60 parts, Rhizoma Rodgersiae 40 parts, Cortex fici lacoris 40 parts, Herba Aristolochiae 20 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 40 parts, Herba Hyperici 40 parts, Radix Gynurae 20 parts, Bombyx mori L. 10 parts, Five Dragons skin 50 parts, Fructus Linderae 30 parts, Fructus Litseae 40 parts, Cortex Cinnamomi Burmannii 30 parts, Bullus Notholirionis Bulbuliferi 50 parts, Herba Clematidis Meyenianae 30 parts, Fructus Citri 50 parts, Caulis Seu Radix Kadsurae Oblongifoliae 30 parts, Caulis Polygoni Multiflori 30 parts, crow Buddhist nun joins 20 parts, Semen Astragali Complanati 30 parts, Fructus Polygoni Orientalis 20 parts, Radix Cucubali 40 parts.
5. the preparation method of the Chinese medicine preparation for the treatment of dysmenorrhea as described in as arbitrary in claim 1-4, it is characterized in that, described preparation method is made up of following steps:
(1) Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Cortex fici lacoris, excrementum bombycis meal are broken into fine powder;
(2) get Caulis Polygoni Multiflori, Fructus Leonuri, Fructus Citri medical material, adding medical material weight ratio is 8 ~ 10 times amount 50 ~ 70% ethanol, heating and refluxing extraction 2 times, each 0.5 ~ 2h, filter, merging filtrate also reclaims ethanol extremely without after alcohol taste, concentrate drying, and be ground into dried cream powder, sieve, medicinal residues are for subsequent use;
(3) step medicinal residues are (2) merged with Caulis Marsdeniae tinctoriae, Folium Zingiberis, Herba Centrantherae Cochinchinensis, Cortex cercis chinensis, Rhizoma Rodgersiae, Herba Aristolochiae, Herba Hyperici, Radix Gynurae, Five Dragons skin, Fructus Linderae, Fructus Litseae, Cortex Cinnamomi Burmannii, Bullus Notholirionis Bulbuliferi, Herba Clematidis Meyenianae, Caulis Seu Radix Kadsurae Oblongifoliae, Wu Nican, Semen Astragali Complanati, Fructus Polygoni Orientalis, Radix Cucubali medical material again, adding with medical material weight ratio is the soak by water 1 ~ 3 time of 9 ~ 11 times amount, each 0.5 ~ 2h, filter, merging filtrate, concentrating under reduced pressure is dry, and is ground into dried cream powder, for subsequent use;
(4) get above-mentioned steps (1) in fine powder, step (2), (3) in dried cream powder, after mixing, obtain Traditional Chinese drug mixture, then to add on pharmaceutics conventional adjuvant and make various different oral formulations, to obtain final product.
6. treat the preparation method of the Chinese medicine preparation of dysmenorrhea as claimed in claim 5, it is characterized in that, described preparation method is made up of following steps:
(1) Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Cortex fici lacoris, excrementum bombycis meal are broken into fine powder;
(2) get Caulis Polygoni Multiflori, Fructus Leonuri, Fructus Citri medical material, adding medical material weight ratio is 9 times amount 60% ethanol, heating and refluxing extraction 2 times, each 1h, filters, and merging filtrate also reclaims ethanol extremely without after alcohol taste, concentrate drying, and is ground into dried cream powder, and sieve, medicinal residues are for subsequent use;
(3) step medicinal residues are (2) merged with Caulis Marsdeniae tinctoriae, Folium Zingiberis, Herba Centrantherae Cochinchinensis, Cortex cercis chinensis, Rhizoma Rodgersiae, Herba Aristolochiae, Herba Hyperici, Radix Gynurae, Five Dragons skin, Fructus Linderae, Fructus Litseae, Cortex Cinnamomi Burmannii, Bullus Notholirionis Bulbuliferi, Herba Clematidis Meyenianae, Caulis Seu Radix Kadsurae Oblongifoliae, Wu Nican, Semen Astragali Complanati, Fructus Polygoni Orientalis, Radix Cucubali medical material again, adding with medical material weight ratio is the soak by water 2 times of 10 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure is dry, and is ground into dried cream powder, for subsequent use;
(4) get above-mentioned steps (1) in fine powder, step (2), (3) in dried cream powder, after mixing, obtain Traditional Chinese drug mixture, then to add on pharmaceutics conventional adjuvant and make various different oral formulations, to obtain final product.
7. the Chinese medicine preparation for the treatment of dysmenorrhea as described in as arbitrary in claim 1-4, it is characterized in that, the dosage form of described Chinese medicine preparation is peroral dosage form.
8. treat the Chinese medicine preparation of dysmenorrhea as claimed in claim 7, it is characterized in that, the dosage form of described Chinese medicine preparation is preferably capsule.
9. the application of the Chinese medicine preparation as described in as arbitrary in claim 1-4 in preparation treatment dysmenorrhea medicine.
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| CN105999065A (en) * | 2016-06-15 | 2016-10-12 | 唐家婷 | Traditional Chinese medicine preparation for treating diabetes and preparation method thereof |
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Application publication date: 20151223 |