CN106822261A - Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof - Google Patents
Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof Download PDFInfo
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Abstract
Pharmaceutical composition of neurodermatitis and preparation method thereof is prevented and treated the invention discloses a kind of, pharmaceutical composition of the present invention is with Lonicera caerulea, Herba oxygraphis glacialis, Oblongleaf Heterostemma, goose egg-shell, Radix Thyrocarpi sampsonii as bulk drug, proportioning is formed, routinely various formulations can be made by preparation process, prevent and treat neurodermatitis evident in efficacy.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for preventing and treating neurodermatitis and its preparation
Method.
Background technology
Neurodermatitis, also known as lichen simplex chronicus, is Major Clinical table with strange the itching of skin lichenification and paroxysmal
It is existing, it is a kind of cutaneous nerve functional disorder disease.Because its course of disease is long, easy recurrent exerbation, stubbornness is refractory to be also called " stubborn dermatitis ".This
Disease is more common in person between twenty and fifty, and the elderly is more rare, and children do not fall ill typically, and pathogenesis is complicated.Modern medicine thinks, itself and plant
Neurological dysfunction, cerebral cortex be excited and process of inhibition dysequilibrium, minimal invasive treatment's environment and psychological factor etc. are relevant,
Wherein psychoneural factor, irritable food, local excitation is considered as main inducing, cryptorrhea and infectious lesionses
In the presence of can also fall ill.With special curative effect, it is the main side for treating the disease that clinically medicine is applied outward at present to this disease of Chinese traditional treatment
Effectively, but there is certain adverse reaction in method, local injection or oral glucocorticoid, the state of an illness is easily repeatedly.Diagnosis and prescription, because people because
Disease and it is different, be independent of hormone, it is evident in efficacy, it is intended to dispel the cause of disease, prevent recurrence, favored by patient.Neurodermatitis belongs to
Neuropsychiatric disorders dermatoses, the cause of disease is not yet clear and definite.Motherland's medical science thought because main within the disease, and smooth, mind is not or not feelings will
Peace heart-fire hyperactivity etc. can cause energy and blood of human body uncomfortable, and with the passing of time impairment of yin is taken offence hematozemia, then blood-deficiency and wind-dry, it is impossible to the foster skin of honor and send out
Disease；With the passing of time external cause can gather because experiencing the perverse trend such as wind, wet and hot falls ill in skin.Factors, the essences such as the work of today's society family
Refreshing overstretched and anxiety, the fluctuation of mood can all turn into the inducement of its morbidity and recurrent exerbation.
Lonicera caerulea：It is Caprifoliaceae woodbine Lonicera caerulea Lonicera caerulea L.var .edulis
Turcdz. the fruit of Ex Herd..Gathered after 8-9 month fruit maturations, dried.【Nature and flavor】Bitter；It is cool in nature.【Indication】Clearly
Thermal detoxification；Dissipate carbuncle detumescence.Main furunculosis；Acute mastitis；Acute appendicitis；Erysipelas；Damp-heat dysentery.【Pharmacological action】Antihypertensive effect：Lonicera caerulea is concentrated
Every 80ml of fruit juice, duodenal tube administration, the blood pressure to normotensive anesthetized dog has no significant effect, but to drip-feed
Adrenalin hydrochloride makes the elevated dog of blood pressure, and 26 minutes blood pressures start slow decline after administration, and 2 hourly averages decline 3.58kPa
（27mmHg）, and the hypertension of non-medication group animal is hardly reduced.The characteristics of Lonicera caerulea juice antihypertensive effect is rapid-action, effect
It is gentle and lasting, have no adverse reaction.【Former phytomorph】Lonicera caerulea machaka, 1.5m high.Sprout by hair, old branch rufous,
Often there is the stipule of big shape plate-like in vigorous branches section portion.Leaf opposite；Petiole is extremely short；Leaf ground paper matter, blade Long Circle, ovate Long Circle, ovum
Shape is oval, dilute avette, 2-5cm long, 1-3cm wide, and tip is sharp or slightly blunt, basal circular, the nearly full edge of leaf margin, has cilium, two sides
Dredge by raw undercoat, below middle arteries hair it is closeer, it is sometimes several without hair.Total bennet 2-10mm long；Bract bar shaped, 2-3 times of a length of calyx tube；
Corolla yellow-white, tubular infundibulate, 1-1.3cm long, outer by pubescence, base portion has shallow capsule, sliver 5；Stamen 5, slightly stretch out corolla it
Outward；Style is stretched out outside corolla without hair.Berry is black-and-blue, oval, 1.5cm is about, slightly by white powder.The month at florescence 5-6, fruiting period 8-9
Month.Record in dictionary of medicinal plant.
Herba oxygraphis glacialis：This product is Ranunculaceae Herba oxygraphis glacialis platymiscium Herba oxygraphis glacialis Oxygraphis glacialis (Fisch.)
The herb of Bunpe [Ficaria glacialis Fisch.ex DC.].The 7-8 months pick flowers or herb, clean, and dry.【Nature and flavor】
Mildly bitter flavor；It is cold in nature.【Return through】Lung；Liver Channel.【Indication】Stasis-dispelling and pain-killing；Heat-clearing and damp-drying drug；Removing toxic substances.Main head injury；Hemostasis aches
Bitterly；Sore.【Proterties】Rhizome is shorter, diameter 3-6mm.Fibrous root is grown thickly, brown to dark brown, and long up to 20cm, diameter is less than
1mm, the vertical straight burr of tool；Plane of rupture brown.Leafage life, yellow green, blade oval or Long Circle, 0.2-2.8cm long, 0.5- wide
2.2cm；Petiole 1-4cm long, narrow wing is arranged at top.Flower shrinkage is agglomerating, sepal 5, subcircular, yellow green；Petal brown, takes off sometimes
Fall, stamen is most.Gas is fragrant, taste is pungent.Record in dictionary of medicinal plant.
Radix Thyrocarpi sampsonii：The herb of Boraginaceae Radix Thyrocarpi sampsonii platymiscium Radix Thyrocarpi sampsonii Thyrocarpus sampsonii Hance.4~6
The moon adopts herb, dries.【Nature and flavor】It is bitter；It is cool.【Return through】The heart；Large intestine channel.【Indication】Clearing heat, releasing toxin, removing swelling.Main carbuncle swells；Malignant boil
Sore；Have sore throat；Diarrhea；Dysentery.【Proterties】Stem is thinner, and 1 to several, cylinder, 10-30cm long, the withered green in surface has greyish white
Color rough hair, the crisp frangibility of matter, section white.Basal leaf is grown thickly, shrinkage curling, and after moistening is launched, cochlear has handle, 3.5- long
19cm, 1-5cm wide, withered green or bottle green, two sides have canescence coarse wool, and stem leaf is smaller, stockless.Blade is slightly thick.Sometimes
It can be seen that blue or purple little Hua.Or having the pyrene of the bowl-shape projection of two-layer, base top exterior layer has upright gear, and internal layer is close to side
Edge.The micro- mildly bitter flavor of gas.Record in dictionary of medicinal plant.
Oblongleaf Heterostemma：This product is dicotyledon medicine Asclepiadaceae Winged Heterostemma platymiscium Oblongleaf Heterostemma Hetrostemma
The complete stool of oblongifolium Cost..Autumn harvests, and dries.【Nature and flavor】It is slight bitter, sweet；It is flat.【Return through】Liver Channel.【Function master
Control】Lactagogue.Qi and blood stasis after main product；Agalactia.【Former phytomorph】Weak winding liana.Complete stool has milk, and stem is by 2 row
Pubescence.Leaf opposite；Petiole 2-4cm long；Blade Long Circle, dilute ovate Long Circle, 7.5-11cm long, 3.5-4.5cm wide, tip is sharp
Point, basal circular；Per side 5-7 bars, arc rises lateral vein.Umbrella shape shape cyme axillary, 2-3cm long is blossomed 4-5；Calyx 5
Drastic crack, inner face base portion has body of gland about 10；Corolla outside light green, inner face yellow, spoke shape, diameter 1-1.5cm；Corolla splits levies 5,
Cover to the right；Paracorolla five-pointed star aristiform, the every room 1 of massula, square circular, uprightly.Follicle radish fruit wire lanceolar, is up to
12cm, diameter about 1cm, it is tapering to tip.Seed is up to 2cm, about 3mm wide, white thin,tough silk matter kind hair of the seed tool up to 3cm.Flower
Month phase 8-10, the fruiting period 9-12 months.Record in dictionary of medicinal plant.
Goose egg-shell：This product belongs to the ovum of animal man goose Anser cygnoides domestica Brisson. for Anatidae wild goose
Shell.During edible goose egg, eggshell is collected, cleaned, dried or dry.【Nature and flavor】It is sweet；It is light；It is flat.【Return through】Lung channel.【Indication】Pull out
Malicious apocenosis；Regulating qi-flowing for relieving pain.Main ulcer purulence is burst into hardly possible；Hernia；Difficult labour.【Proterties】Fragment shape is presented, outer surface white is slightly coarse more,
It is easily rupturable；Inner surface is smooth, and matter is crisp frangible.Gas is micro-, lightly seasoned.Record in dictionary of medicinal plant.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of drug regimen for effectively preventing and treating neurodermatitis
Thing and preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition for preventing and treating neurodermatitis be：
Lonicera caerulea 220-226 weight portion Herba oxygraphis glacialis 230-238 weight portion Oblongleaf Heterostemma 210-214 weight portion goose egg-shells 130-134
Weight portion Radix Thyrocarpi sampsonii 110-112 weight portions.
The pharmaceutical composition for preventing and treating neurodermatitis is preferably used in, is made up of the bulk drug of following weight portion：
The weight portion Radix Thyrocarpi sampsonii 111 of 212 weight portion goose egg-shell of Lonicera caerulea 223 weight portion Herba oxygraphis glacialis, 234 weight portion Oblongleaf Heterostemma 132
Weight portion.
A kind of pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition can be using the normal of galenic pharmacy
Rule method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine
Prevent and treat neurodermatitis medicine.
A kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Lonicera caerulea 220-226 weight portion Herba oxygraphis glacialis 230-238 weight portion Oblongleaf Heterostemmas 210-
214 weight portion goose egg-shell 130-134 weight portion Radix Thyrocarpi sampsonii 110-112 weight portions；
Preparation method：
（1）Lonicera caerulea, Herba oxygraphis glacialis, Oblongleaf Heterostemma, goose egg-shell, Radix Thyrocarpi sampsonii are taken by bulk drug proportioning, is mixed, use weight percent concentration
43% ethanol takes as solvent in 28 DEG C of temperature extractions, and extraction time is 14 times, and each extraction time is 11 hours, and each solvent is used
It is 18 times of bulk drug gross weight to measure, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density
1.05, filtration, liquid is first washed with water by LK001 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 54%
Liquid wash-out LK001 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 54%, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 61% as solvent, heating and refluxing extraction 8 times is carried every time
The time is taken for 1.2 hours, each solvent load is 31 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns
The ethanol solution of weight percent concentration 83% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 83%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that make as follows
It is standby：
The composition and weight portion of bulk drug be：The weight portion goose of 223 weight portion Herba oxygraphis glacialis of Lonicera caerulea, 234 weight portion Oblongleaf Heterostemma 212
The weight portion of 132 weight portion Radix Thyrocarpi sampsonii of eggshell 111；
Preparation method：
（1）Lonicera caerulea, Herba oxygraphis glacialis, Oblongleaf Heterostemma, goose egg-shell, Radix Thyrocarpi sampsonii are taken by bulk drug proportioning, is mixed, use weight percent concentration
43% ethanol takes as solvent in 28 DEG C of temperature extractions, and extraction time is 14 times, and each extraction time is 11 hours, and each solvent is used
It is 18 times of bulk drug gross weight to measure, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density
1.05, filtration, liquid is first washed with water by LK001 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 54%
Liquid wash-out LK001 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 54%, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 61% as solvent, heating and refluxing extraction 8 times is carried every time
The time is taken for 1.2 hours, each solvent load is 31 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns
The ethanol solution of weight percent concentration 83% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 83%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition can be used
The conventional method of galenic pharmacy prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that pharmaceutical composition and chemical drugs
Or Chinese medicine composition prevents and treats neurodermatitis medicine.
It is evident in efficacy that pharmaceutical composition prevents and treats neurodermatitis.
Specific embodiment
Embodiment 1：Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：Lonicera caerulea 223g Herba oxygraphis glacialis 234g
Oblongleaf Heterostemma 212g goose egg-shell 132g Radix Thyrocarpi sampsoniis 111g；
Preparation method：
（1）Lonicera caerulea, Herba oxygraphis glacialis, Oblongleaf Heterostemma, goose egg-shell, Radix Thyrocarpi sampsonii are taken by bulk drug proportioning, is mixed, use weight percent concentration
43% ethanol takes as solvent in 28 DEG C of temperature extractions, and extraction time is 14 times, and each extraction time is 11 hours, and each solvent is used
It is 18 times of bulk drug gross weight to measure, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density
1.05, filtration, liquid is first washed with water by LK001 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 54%
Liquid wash-out LK001 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 54%, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 61% as solvent, heating and refluxing extraction 8 times is carried every time
The time is taken for 1.2 hours, each solvent load is 31 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns
The ethanol solution of weight percent concentration 83% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 83%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：Lonicera caerulea 220g Herba oxygraphis glacialis 238g
Oblongleaf Heterostemma 210g goose egg-shell 134g Radix Thyrocarpi sampsoniis 110g；
Preparation method：
（1）Lonicera caerulea, Herba oxygraphis glacialis, Oblongleaf Heterostemma, goose egg-shell, Radix Thyrocarpi sampsonii are taken by bulk drug proportioning, is mixed, use weight percent concentration
43% ethanol takes as solvent in 28 DEG C of temperature extractions, and extraction time is 14 times, and each extraction time is 11 hours, and each solvent is used
It is 18 times of bulk drug gross weight to measure, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density
1.05, filtration, liquid is first washed with water by LK001 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 54%
Liquid wash-out LK001 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 54%, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 61% as solvent, heating and refluxing extraction 8 times is carried every time
The time is taken for 1.2 hours, each solvent load is 31 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns
The ethanol solution of weight percent concentration 83% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 83%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：Lonicera caerulea 226g Herba oxygraphis glacialis 230g
Oblongleaf Heterostemma 214g goose egg-shell 130g Radix Thyrocarpi sampsoniis 112g；
Preparation method：
（1）Lonicera caerulea, Herba oxygraphis glacialis, Oblongleaf Heterostemma, goose egg-shell, Radix Thyrocarpi sampsonii are taken by bulk drug proportioning, is mixed, use weight percent concentration
43% ethanol takes as solvent in 28 DEG C of temperature extractions, and extraction time is 14 times, and each extraction time is 11 hours, and each solvent is used
It is 18 times of bulk drug gross weight to measure, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density
1.05, filtration, liquid is first washed with water by LK001 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 54%
Liquid wash-out LK001 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 54%, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 61% as solvent, heating and refluxing extraction 8 times is carried every time
The time is taken for 1.2 hours, each solvent load is 31 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns
The ethanol solution of weight percent concentration 83% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 83%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 58g of Example 1, adds starch 65g, mixes, and granulation is dried, plus microcrystalline cellulose 33g, stearic acid
Magnesium 2g, mixes, and is pressed into 450, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 150g of Example 2, adds starch 230g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid
Magnesium, mixes, and encapsulated 800, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 180g water-baths and boil molten, add the pharmaceutical composition 12g of embodiment 3, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 4 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.3cm away from liquid level, and drop speed is optimum condition with every point 47 drop, and the cold of dripping pill surface is blotted with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：Prevent and treat the pharmaceutical composition of neurodermatitis
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：
The weight portion of 100 weight portion goose egg-shell of Oblongleaf Heterostemma, 280 weight portion Herba oxygraphis glacialis 190.
Embodiment 8：Prevent and treat the pharmaceutical composition of neurodermatitis
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：
The weight portion of 120 weight portion goose egg-shell of Oblongleaf Heterostemma, 250 weight portion Radix Thyrocarpi sampsonii 160.
Embodiment 9：Prevent and treat the pharmaceutical composition of neurodermatitis
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of neurodermatitis be：
The weight portion of 150 weight portion goose egg-shell of Oblongleaf Heterostemma, 240 weight portion Radix Thyrocarpi sampsonii 170.
Experimental example 1：Prevent and treat the experimental study of neurodermatitis
1st, data and method
This group of patient 25, man 11, female 14；20~45 years old age, averagely about 34 years old；The course of disease 5 months~2.8 years, puts down
Equal 12 months or so.Limitation dermatitis 21, general hair property dermatitis 4；Neck dermatitis 15 in limitation dermatitis, four limbs stretch side
Dermatitis 3, perineum dermatitis 1, scrotum portion dermatitis 1, sacrum portion dermatitis 1.
2nd, treatment method
（1）Medicine is constituted:1. oral drugs are constituted:Pharmaceutical composition（The pharmaceutical composition of embodiment 1, lot number 20100823）.
2. external used medicine is constituted:Saltcake 25g, Bai Fan 30g, pharmaceutical composition 25g.
（2）Process for preparing medicine and usage:1. oral medicament preparation and usage:Medicine is put in marmite, plus in right amount
Clear water is decocted 15 minutes, leaches liquid about 200ml, and the dregs of a decoction are decocted 15 minutes again, leach liquid 200ml.Liquid medicine mixing, divides twice
Into two parts, 1 day dosage divides sooner or later one after each meal twice, takes medicine continuously 20 days 1 courses for the treatment of.2. method for preparing externally applied and usage:
Other drugs add proper amount of clear water to soak 30 minutes in addition to saltcake, white sail, decoct 20 minutes, add saltcake, Bai Fan, treat it
Liquid is filtered out after dissolving.The dregs of a decoction are decocted again, take the about 1000ml of liquid mixing twice, are divided into 2 parts, every part of 1 day dosage.
Smoke while hot and wash affected part, after immersion or drip washing affected part 20 minutes after temperature reduction, 2 times/day, two days 1 dose, 10 dose (20
My god) 1 course for the treatment of.3. there are the patient of lichenification, plus local injection prednisolone (prednisolone) and lidocaine, weekly 1
It is secondary, 3 weeks 1 courses for the treatment of.
3rd, curative effect judging standard:
1. fully recover:Clinical symptom disappearance, deflorescence, half a year is without recurrence；
2. take a turn for the better:Clinical symptom relief or disappearance, fash partial remission or regression, there is recurrence in half a year；
3. it is invalid:, without improvement, fash is without regression for clinical symptoms.
4th, result
In 25 patients, fully recover 17, take a turn for the better 7, invalid 1.Total effective rate 96.00%.
5th, model case
Patient Zhang, man, 32 years old, town dweller, the first visit of in January, 2012, after readme neck, two after elbow at local paroxysmal scabies
Itch more than 12 months, often because of anxious state of mind, itch aggravation after maror of drinking or take food, the various external-applied ointments of application of being in (
Fluocinolone acetonide, Pevisone etc.) embrocate treatment, when it is good when it is bad, less effective is gone to a doctor.Check:Dry skin after the elbow of after neck and both sides
Thick thick, lichenification, clear border, the visible a little flat papule of surrounding, surface is scratched vestige, and visible polygonal is flat after elbow
Papule, the colour of skin is in pale red, is diagnosed as neurodermatitis.1 course for the treatment of is treated in aforementioned manners, is subject to local injection prednisone
Dragon and 1 course for the treatment of of lidocaine, clinical symptom disappearance, deflorescence.Follow-up is not recurred so far.
Patient it is single so-and-so, man, 39 years old.Main cause face redness itch with lichenification more than January, on April 15th, 2012 just
Examine.The overtime work of staying up late of patient's readme continuous several months is arrayed data, and feels that especially circumference of eyes red and swollen itch occurs with transparent to face
Vesicle, liquid is constantly outwards overflowed, and face links closely like shell, a thick layer of, and pain unbearably, is had the fidgets.Once dermatitis is used
Grain and external medication, it is not notable through 1 wheat harvesting period therapeutic effect.Quarter examines：Lassitude, it is irritated, to receive less, insomnia, tongue is red, tongue
It is greasy, wiry and frequent pulse.Tcm diagnosis：Psoriasis, it is dialectical：The evil heap soil or fertilizer over and around the roots resistance skin of rheumatic fever three causes qi-blood disharmony.Doctor trained in Western medicine is diagnosed：Nerve
Dermatitis.Principle of reatment：Clearing heat, detoxicating, dispelling dampness, the carbuncle myogenic that disappears of invigorating blood circulation.1 course for the treatment of is treated in aforementioned manners, and face is as usual, does not stay
Scar, and follow-up 1 year, do not recur again.
Claims (8)
1. a kind of pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that be made the composition of the bulk drug of the pharmaceutical composition
It is with weight portion：
Lonicera caerulea 220-226 weight portion Herba oxygraphis glacialis 230-238 weight portion Oblongleaf Heterostemma 210-214 weight portion goose egg-shells 130-134
Weight portion Radix Thyrocarpi sampsonii 110-112 weight portions.
2. a kind of pharmaceutical composition for preventing and treating neurodermatitis according to claim 1, it is characterised in that be made the medicine group
The composition and weight portion of the bulk drug of compound be：
The weight portion Radix Thyrocarpi sampsonii 111 of 212 weight portion goose egg-shell of Lonicera caerulea 223 weight portion Herba oxygraphis glacialis, 234 weight portion Oblongleaf Heterostemma 132
Weight portion.
3. a kind of pharmaceutical composition for preventing and treating neurodermatitis according to claim 1, it is characterised in that pharmaceutical composition can
Piece agent or capsule or dripping pill are prepared with using the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for preventing and treating neurodermatitis according to claim 1, it is characterised in that pharmaceutical composition with
What chemical drugs or Chinese medicine were constituted prevents and treats neurodermatitis medicine.
5. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Lonicera caerulea 220-226 weight portion Herba oxygraphis glacialis 230-238 weight portion Oblongleaf Heterostemmas 210-
214 weight portion goose egg-shell 130-134 weight portion Radix Thyrocarpi sampsonii 110-112 weight portions；
Preparation method：
（1）Lonicera caerulea, Herba oxygraphis glacialis, Oblongleaf Heterostemma, goose egg-shell, Radix Thyrocarpi sampsonii are taken by bulk drug proportioning, is mixed, use weight percent concentration
43% ethanol takes as solvent in 28 DEG C of temperature extractions, and extraction time is 14 times, and each extraction time is 11 hours, and each solvent is used
It is 18 times of bulk drug gross weight to measure, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density
1.05, filtration, liquid is first washed with water by LK001 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 54%
Liquid wash-out LK001 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 54%, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 61% as solvent, heating and refluxing extraction 8 times is carried every time
The time is taken for 1.2 hours, each solvent load is 31 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns
The ethanol solution of weight percent concentration 83% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 83%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis according to claim 5, it is characterised in that press
It is prepared by following steps：
The composition and weight portion of bulk drug be：The weight portion goose of 223 weight portion Herba oxygraphis glacialis of Lonicera caerulea, 234 weight portion Oblongleaf Heterostemma 212
The weight portion of 132 weight portion Radix Thyrocarpi sampsonii of eggshell 111；
Preparation method：
（1）Lonicera caerulea, Herba oxygraphis glacialis, Oblongleaf Heterostemma, goose egg-shell, Radix Thyrocarpi sampsonii are taken by bulk drug proportioning, is mixed, use weight percent concentration
43% ethanol takes as solvent in 28 DEG C of temperature extractions, and extraction time is 14 times, and each extraction time is 11 hours, and each solvent is used
It is 18 times of bulk drug gross weight to measure, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density
1.05, filtration, liquid is first washed with water by LK001 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 54%
Liquid wash-out LK001 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 54%, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 61% as solvent, heating and refluxing extraction 8 times is carried every time
The time is taken for 1.2 hours, each solvent load is 31 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.16 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns
The ethanol solution of weight percent concentration 83% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 83%
Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis according to claim 5, it is characterised in that medicine
Compositions can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition for preventing and treating neurodermatitis according to claim 5, it is characterised in that medicine
Compositions prevent and treat neurodermatitis medicine with chemical drugs or Chinese medicine composition.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611133236.8A CN106822261A (en) | 2016-12-10 | 2016-12-10 | Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611133236.8A CN106822261A (en) | 2016-12-10 | 2016-12-10 | Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106822261A true CN106822261A (en) | 2017-06-13 |
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ID=59139076
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611133236.8A Withdrawn CN106822261A (en) | 2016-12-10 | 2016-12-10 | Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof |
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| Country | Link |
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| CN (1) | CN106822261A (en) |
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2016
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Application publication date: 20170613 |