CN106822230A - Treat pharmaceutical composition of cerebral thrombus and preparation method thereof - Google Patents
Treat pharmaceutical composition of cerebral thrombus and preparation method thereof Download PDFInfo
- Publication number
- CN106822230A CN106822230A CN201611134472.1A CN201611134472A CN106822230A CN 106822230 A CN106822230 A CN 106822230A CN 201611134472 A CN201611134472 A CN 201611134472A CN 106822230 A CN106822230 A CN 106822230A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- ethanol
- pharmaceutical composition
- weight
- percent concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Pharmaceutical composition of cerebral thrombus and preparation method thereof is treated the invention discloses a kind of, pharmaceutical composition of the present invention is with climbing seedbox herb, mongolian jurinea tomentum, thickfruit millettia seed or fruit, lightyellow sophora seed, choline bromide 1,1,2,2 D4, alpha pinene oxides are bulk drug, proportioning is formed, and routinely can be made various formulations by preparation process, and treatment cerebral thrombus is evident in efficacy.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for treating cerebral thrombus and its preparation side
Method.
Background technology
Cerebral thrombus motherland medical science is referred to as headstroke or cerebral apoplexy.Show according to investigation statisticses in recent years, about 75% survival
Patient leave different degrees of hemiplegia.The disease is mainly in old age, is declined by asthenia of qi and blood more, work and rest immoderation, intemperance of taking food, causes
The turbid interior life of phlegm, stagnation of the circulation of vital energy blood tinea, train of thought are blocked and are fallen ill.Current cerebral thrombosis treatment is with " qi and activate blood circulation, disperse blood stasis and dredge collateral, slit phlegm
Have one's ideas straightened out " based on, but effect on driving birds is not good.
Climbing seedbox herb：It is the herb of willow leaf Lay section plant of clove knotweed.Taken during autumn result.【Original shape state】Annual herb.
Fibrous root is most.Prostration on the ground, or is made to incline sleeping shape during seedling, after put forth it is upright, it is long 20~50 centimetres.Stem has corner angle, multi-branched, branch
Band square, aubergine, all Glabrous are all become to autumn cauline leaf.Single leaf alternate；Blade lanceolar, it is long 4~7.5 centimetres, it is wide by 1
~2 centimetres, tip is tapering, and full edge, base portion is gradually narrow, and petiole is long not as good as blade half.Flower axillary, usual 1~2, without stalk；Calyx
4~5 split, and sliver is avette, are about 2 millimeters, and there is fine, soft fur outside, harbors；With calyx lobes with number, ellipse is about 3 millis to petal
Rice, tip blunt circle, base portion is narrow, makees shortly clawed shape, early de-；Stamen 4~5；Ovary is the next, and outside is close by short fine, soft fur, and Room 4, style is short,
Column cap is single, head.Capsule wire square, upright or micro-bend, two ends are cut off, long 15~20 millimeters, ripe time-varying purple；
Seed is tiny, smooth, brown color.7~August of florescence.9~October of fruiting period.【Nature and flavor】Hardship, it is cool.①《Fujian traditional herbal medicine》：" it is sweet,
It is flat."②《Traditional Chinese Medicine in Sichuan will》：" cool in nature, bitter and puckery flavor, it is nontoxic."③《Fujian Chinese herbal medicine》：" slight bitter is pungent, cool."【Indication】Profit
Urine detumescence, it is clearing heat and detoxicating.Control oedema, gonorrhoea, dysentery, leukorrhea, ulcer, furunculosis.①《Middle traditional Chinese medicines plant will》：" control red-white dysentery."
②《Fujian traditional herbal medicine》：" diuresis is subsided a swelling swollen."③《Quanzhou book on Chinese herbal medicine》：" clearing heat and detoxicating, promoting diuresis for stranguria.Control oedema, blood strangury, carbuncle
Subcutaneous ulcer, furunculosis, nameless sores or boils."③《Plant medicine investigation in Guizhou》：" heat-clearing, cough-relieving."【Take passages】《Dictionary of medicinal plant》.
Mongolian jurinea tomentum：Composite family mongolian jurinea tomentum Jurinea potanini Iijin, are used as medicine with whole herb with root and basal part of stem wool.
【Nature and flavor】Basal part of stem wool：It is light, put down.Herb：Hardship, it is cool.【Indication】Basal part of stem fine hair：Hemostasis.Herb：Detumescence.【Take passages】
《National Chinese herbal medicine compilation》.
Thickfruit millettia seed or fruit：It is the seed of legume Millettia pachycarpa Benth.Harvested after fruit maturation.Pericarp is removed, seed is dried.
【Proterties】Proterties differentiates that seed is oblate and slightly kidney-shaped, the raw seed at pod two ends, and simultaneously circular, another side is truncate；Occupy
Seed in the middle of pod, two sides is truncate；It is about 4cm, thickness about 3cm.Surface rufous is glossy to dark brown, or carries
Linen film, omphalion is located at middle waist excavated part.Cotyledon 2, plump, cutin sample, easy lobe；Have irregular around nearly omphalion
Projection, make cotyledon lobe and uneven.【Chemical composition】Seed contains rotenone (rotenone) and rotenoid
(rotenoids).【Nature and flavor】It is bitter；It is pungent；Property heat；Big poison.【Return through】Spleen；Stomach.【Indication】Attack malicious analgesic；Disperse accumulations desinsection.
Main mange sore leprosy；Eruptive disease is suffered from abdominal pain；Infantile malnutrition.【Take passages】《Chinese book on Chinese herbal medicine》.
Lightyellow sophora seed：It is the seed of legume kuh-seng Sophora flavescens Ait..Adopted during 7-8 month fruit maturations
Receive, dry, lay seed, remove shell, impurity, then dry.【Chemical composition】Contain left-handed 5a- hydroxyls sophocarpine in seed
（5a-hydroxyophocarpine）, left-handed sophocarpine（sophocarpine）, Jumex-methylcytisine（N-
methylcytisine）, dextrorotation 9a- ammothamnines（9a-hydroxymatrine）, left-handed 5a, 9a- dihydroxyl matrines
（5a, 9a-dihydroxymatrine）, dextrorotation matrine-N- oxides（matrine-N-oxide）, dextrorotation sophoranl-N- oxygen
Compound（sophoranol N-oxide）.【Nature and flavor】It is bitter；It is cold.【Return through】Liver；Spleen；Large intestine channel.【Indication】It is clearing heat and detoxicating；It is logical
Just；Desinsection.Main acute bacillary dysentery；Constipation；Ascariasis.【Take passages】《Chinese book on Chinese herbal medicine》.
Choline bromide -1,1,2,2-D4（Choline-1,1,2,2-D4 Bromide）：Molecular formula：C5H10BrD4NO.Point
Son amount：188.10, CAS accession number：285979-69-3.
Alpha- pinene oxides（alpha-Pinene Oxide）：Molecular formula：C10H16O,Molecular weight：152.24, CAS step on
Record number：1686-14-2 (25488-94-2).Density：1.027g/cm3（Calculated value）.Boiling point：102-103°C（Experiment value）
188.647°C at 760 mmHg（Calculated value）.Flash-point：65.556°C（Calculated value）66°C（Experiment value）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided it is a kind of it is effective treatment cerebral thrombus pharmaceutical composition and
Its preparation method.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition of the treatment cerebral thrombus be：
The weight portion kuh-seng of 7425-7525 weight portion thickfruit millettia seed or fruit of the weight portion of climbing seedbox herb 6525-6625 mongolian jurinea tomentum 2325-2425
Real 1625-1725 weight portion choline bromide-1,1,2,2-D496-106 weight portion alpha- pinene oxides 105-115
Weight portion.
The pharmaceutical composition for the treatment of cerebral thrombus is preferably used in, is made up of the bulk drug of following weight portion：
The weight portion bromination of 2375 weight portion lightyellow sophora seed of climbing seedbox herb 6575 weight portion mongolian jurinea tomentum, 7475 weight portion thickfruit millettia seed or fruit 1675
The weight portion of choline -1,1,2,2-D4101 weight portion alpha- pinene oxides 110.
A kind of pharmaceutical composition for treating cerebral thrombus, it is characterised in that pharmaceutical composition can be using the routine side of galenic pharmacy
Method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for treating cerebral thrombus, it is characterised in that pharmaceutical composition and controlling that chemical drugs or Chinese medicine are constituted
Treat cerebral thrombus medicine.
A kind of preparation method of the pharmaceutical composition for treating cerebral thrombus, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：The weight portion of the weight portion of climbing seedbox herb 6525-6625 mongolian jurinea tomentum 7425-7525 hardship wingceltis
Sub weight portion choline bromide-1,1,2,2-D496-106 weight portion of 2325-2425 weight portion lightyellow sophora seed 1625-1725
The weight portion of alpha- pinene oxides 105-115；
Preparation method：
（1）By bulk drug proportioning water intaking cloves, mongolian jurinea tomentum, thickfruit millettia seed or fruit, lightyellow sophora seed, choline bromide -1,1,2,2-D4, alpha- pinanes
Olefinic oxide, mixes, and with the ethanol of weight percent concentration 34% as solvent, is taken in 44 DEG C of temperature extractions, and extraction time is 7 times, often
Secondary extraction time is 26 hours, and each solvent load is 46 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, is carried
Take liquid A and reclaim ethanol, be concentrated into relative density 1.16, filter, liquid is first washed with water by LSA-40 large pore resin absorption columns
It is de-, then LSA-40 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 59%, collect weight percent concentration
59% ethanol eluate, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 41% as solvent, heating and refluxing extraction 4 times is carried every time
The time is taken for 1.4 hours, each solvent load is 14 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use weight by DM11 large pore resin absorption columns
The ethanol solution of percent concentration 64% elutes DM11 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 64%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for treating cerebral thrombus, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：The weight portion of 6575 weight portion mongolian jurinea tomentum of climbing seedbox herb, 7475 weight portion thickfruit millettia seed or fruit 2375
The weight portion of 1675 weight portion choline bromide -1,1,2,2-D4101 weight portion alpha- pinene oxides of lightyellow sophora seed 110；
Preparation method：
（1）By bulk drug proportioning water intaking cloves, mongolian jurinea tomentum, thickfruit millettia seed or fruit, lightyellow sophora seed, choline bromide -1,1,2,2-D4, alpha- pinanes
Olefinic oxide, mixes, and with the ethanol of weight percent concentration 34% as solvent, is taken in 44 DEG C of temperature extractions, and extraction time is 7 times, often
Secondary extraction time is 26 hours, and each solvent load is 46 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, is carried
Take liquid A and reclaim ethanol, be concentrated into relative density 1.16, filter, liquid is first washed with water by LSA-40 large pore resin absorption columns
It is de-, then LSA-40 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 59%, collect weight percent concentration
59% ethanol eluate, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 41% as solvent, heating and refluxing extraction 4 times is carried every time
The time is taken for 1.4 hours, each solvent load is 14 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use weight by DM11 large pore resin absorption columns
The ethanol solution of percent concentration 64% elutes DM11 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 64%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for treating cerebral thrombus, it is characterised in that pharmaceutical composition can use preparation
Conventional method prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for treating cerebral thrombus, it is characterised in that pharmaceutical composition and chemical drugs or in
Medicine composition treatment cerebral thrombus medicine.
Specific embodiment
Embodiment 1：Treat pharmaceutical composition of cerebral thrombus and preparation method thereof
Treat cerebral thrombus pharmaceutical composition bulk drug composition and weight portion be：The weight portion mongolian jurinea tomentum of climbing seedbox herb 6575
Weight portion choline bromide -1,1,2,2-D4101 the weight portions of 7475 weight portion thickfruit millettia seed or fruit, 2375 weight portion lightyellow sophora seed 1675
The weight portion of alpha- pinene oxides 110；
Preparation method：
（1）By bulk drug proportioning water intaking cloves, mongolian jurinea tomentum, thickfruit millettia seed or fruit, lightyellow sophora seed, choline bromide -1,1,2,2-D4, alpha- pinanes
Olefinic oxide, mixes, and with the ethanol of weight percent concentration 34% as solvent, is taken in 44 DEG C of temperature extractions, and extraction time is 7 times, often
Secondary extraction time is 26 hours, and each solvent load is 46 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, is carried
Take liquid A and reclaim ethanol, be concentrated into relative density 1.16, filter, liquid is first washed with water by LSA-40 large pore resin absorption columns
It is de-, then LSA-40 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 59%, collect weight percent concentration
59% ethanol eluate, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 41% as solvent, heating and refluxing extraction 4 times is carried every time
The time is taken for 1.4 hours, each solvent load is 14 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use weight by DM11 large pore resin absorption columns
The ethanol solution of percent concentration 64% elutes DM11 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 64%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Treat pharmaceutical composition of cerebral thrombus and preparation method thereof
Treat cerebral thrombus pharmaceutical composition bulk drug composition and weight portion be：The weight portion mongolian jurinea tomentum of climbing seedbox herb 6525
Weight portion choline bromide -1,1,2,2-D496 the weight portions of 7525 weight portion thickfruit millettia seed or fruit, 2325 weight portion lightyellow sophora seed 1725
The weight portion of alpha- pinene oxides 115；
Preparation method：
（1）By bulk drug proportioning water intaking cloves, mongolian jurinea tomentum, thickfruit millettia seed or fruit, lightyellow sophora seed, choline bromide -1,1,2,2-D4, alpha- pinanes
Olefinic oxide, mixes, and with the ethanol of weight percent concentration 34% as solvent, is taken in 44 DEG C of temperature extractions, and extraction time is 7 times, often
Secondary extraction time is 26 hours, and each solvent load is 46 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, is carried
Take liquid A and reclaim ethanol, be concentrated into relative density 1.16, filter, liquid is first washed with water by LSA-40 large pore resin absorption columns
It is de-, then LSA-40 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 59%, collect weight percent concentration
59% ethanol eluate, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 41% as solvent, heating and refluxing extraction 4 times is carried every time
The time is taken for 1.4 hours, each solvent load is 14 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use weight by DM11 large pore resin absorption columns
The ethanol solution of percent concentration 64% elutes DM11 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 64%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Treat pharmaceutical composition of cerebral thrombus and preparation method thereof
Treat cerebral thrombus pharmaceutical composition bulk drug composition and weight portion be：The weight portion mongolian jurinea tomentum of climbing seedbox herb 6625
Weight portion choline bromide -1,1,2,2-D4106 the weight portions of 7425 weight portion thickfruit millettia seed or fruit, 2425 weight portion lightyellow sophora seed 1625
The weight portion of alpha- pinene oxides 105；
Preparation method：
（1）By bulk drug proportioning water intaking cloves, mongolian jurinea tomentum, thickfruit millettia seed or fruit, lightyellow sophora seed, choline bromide -1,1,2,2-D4, alpha- pinanes
Olefinic oxide, mixes, and with the ethanol of weight percent concentration 34% as solvent, is taken in 44 DEG C of temperature extractions, and extraction time is 7 times, often
Secondary extraction time is 26 hours, and each solvent load is 46 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, is carried
Take liquid A and reclaim ethanol, be concentrated into relative density 1.16, filter, liquid is first washed with water by LSA-40 large pore resin absorption columns
It is de-, then LSA-40 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 59%, collect weight percent concentration
59% ethanol eluate, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 41% as solvent, heating and refluxing extraction 4 times is carried every time
The time is taken for 1.4 hours, each solvent load is 14 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use weight by DM11 large pore resin absorption columns
The ethanol solution of percent concentration 64% elutes DM11 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 64%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 310g of Example 1, adds starch 100g, mixes, and granulation is dried, plus microcrystalline cellulose 35g, stearic
Sour magnesium 3g, mixes, and is pressed into 1000, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 307g of Example 2, adds starch 85g, mixes, and granulation is dried, whole grain, adds appropriate magnesium stearate,
Mix, encapsulated 1000, obtain final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 193g water-baths and boil molten, add the pharmaceutical composition 14g of embodiment 3, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 5 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.5cm away from liquid level, and drop speed is optimum condition with every point 55 drop, and the cold of dripping pill surface is blotted with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：Treat the pharmaceutical composition of cerebral thrombus
Treat cerebral thrombus pharmaceutical composition bulk drug composition and weight portion be：
Weight portion choline bromide -1,1,2,2-D450 weight portion alpha- the firpenes of 5450 weight portion mongolian jurinea tomentum of climbing seedbox herb 5450
The weight portion of oxide 40.
Embodiment 8：Treat the pharmaceutical composition of cerebral thrombus
Treat cerebral thrombus pharmaceutical composition bulk drug composition and weight portion be：
Weight portion choline bromide -1,1,2,2-D455 weight portion alpha- the firpenes of 5500 weight portion mongolian jurinea tomentum of climbing seedbox herb 5400
The weight portion of oxide 35.
Embodiment 9：Treat the pharmaceutical composition of cerebral thrombus
Treat cerebral thrombus pharmaceutical composition bulk drug composition and weight portion be：
Weight portion choline bromide -1,1,2,2-D445 weight portion alpha- the firpenes of 5400 weight portion mongolian jurinea tomentum of climbing seedbox herb 5500
The weight portion of oxide 45.
Experimental example 1：Treat the experimental study of cerebral thrombus
1 clinical data
The cerebrovascular disease diagnosis standard revised by the Second National cerebrovascular disease academic conference of l986 Chinese Medical Association is selected
Select case.Cerebral thrombus is all diagnosed as on inspection, and some cases are confirmed through head CT examination.
Choose the cerebral thrombus patient of General Hospital of Jinan Military Command in January, 2015~2015 year December treatment, wherein treatment group 80
In example, man 60, female 20, the age is between 37 years old~80 years old；The course of disease 3 days~3.5 years；Internal Carotid System cerebral thrombus 61
Example, vertebral basilar system thrombus 9；Clinical manifestation is hemiplegia 58, aphasia 57, hemidysesthesia 28；Merge high
32 of blood pressure merge coronary heart disease 14.In control group 70, man 52, female 18；40 years old~81 years old age；The course of disease 3 days~
3.6 years, Internal Carotid System cerebral thrombus 63, vertebral basilar system thrombus 7；Clinical manifestation is hemiplegia 48, aphasia 39
Example, hemidysesthesia 20；Complicated hypertension 30, merges coronary heart disease l1.Two groups of clinical datas compare no significant difference,
With comparativity (P>0.05).
2 treatment methods
Treatment group gives the oral pharmaceutical composition（The pharmaceutical composition lot number 20141022 of embodiment 1）, each 1.5g, daily 2
It is secondary.Divide and take for 2 times sooner or later；3 times a day with ring almond fat capsule for treating for control group, and 3 (0.3g) is oral every time.Two groups equal 3
Week is 1 course for the treatment of.Disable that other anti-blood are small to pull aggegation and blood vessel dilatation medicine during treatment.
3 therapeutic effects
3.1 criterions of therapeutical effect are sentenced according to the curative effect of l986 Chinese Medical Association Second National cerebrovascular disease academic conference revision
Calibration standard and " clinical neurologic deficit of stroke patients degree curative effect standards of grading ".Cure：Neurological symptom and sign
Basic disappearance lives are taken care of oneself completely, and state of an illness recovery extent is up to more than 76%：It is effective；Neurological symptom and sign major part disappear
Lose, can independent walking, living section take care of oneself, state of an illness recovery extent reach 5l%~76%.Take a turn for the better：Sings and symptoms partial disappearance, helps
The standing that can leave the bed is held, be can't take care of oneself, state of an illness recovery extent reaches l1%~50%；It is invalid：The state of an illness is not improved after treatment,
Recovery extent is less than l0%, even sb.'s illness took a turn for the worse person.
In 3.2 treatment results treatment groups 80, cure and effective 66, improvement 10, invalid 4, total effective rate is
95.00%；In control group 70, cure and effective 40, take a turn for the better 21, no effect 9 total effective rates are 87.14%.Two groups of treatments
Effect compares significant difference (P<0.O1).
3.3 CT improve first 90 of situation treatment does head CT examination different degrees of ischemic low density area, wherein controlling
Treatment group 50, control group 40.Effective 27 for the treatment of group after treatment, effective 18 total effective rates are 90.0%；Control group shows
Effect 12, effective l6, total effective rate is 70.0%.Two groups relatively have significant difference (P<0.0l).
Electrocardiogram has different degrees of ischemic to change before 3 .4 electrocardiograms improve situation treatment, wherein treatment group 20,
Control group l5.Treatment group is effective l2 after treatment, effective 6, and total effective rate is 90.0 %；Effective 5 effective 5 of control group
Example total effective rates are substantially better than control group (P for 66.7% treatment group's curative effect< 0.01)
Experimental example 2：Model case
Grandson XX, female, 53 years old, hypertension, cerebral thrombus for many years, through hospital treat not by pneumonia in aged, maximal blood pressure 220
More, lower body is unsuccessful, long-term bed, handicapped, glossolalia, gatism, dizzy, and August starts mouth on 23rd within 2015
Take the pharmaceutical composition（The pharmaceutical composition lot number 20141022 of embodiment 1）, each 1.5g, 2 times a day, divides and takes for 2 times sooner or later,
Remember after taking medicine continuously 4 weeks and gradually recover, can be left the bed after one month and help wall to stand, crutch can be leant on after three months substantially and gone into the street row
Walk, after 4 months can activity downstairs, communication that can be more visible with people, 5 Ge Yuehou hospitals check, blood pressure is normal, lipoma
Disappear.
Claims (8)
1. a kind of pharmaceutical composition for treating cerebral thrombus, it is characterised in that be made the composition and weight of the bulk drug of the pharmaceutical composition
Measuring part is：
The weight portion kuh-seng of 7425-7525 weight portion thickfruit millettia seed or fruit of the weight portion of climbing seedbox herb 6525-6625 mongolian jurinea tomentum 2325-2425
Real 1625-1725 weight portion choline bromide-1,1,2,2-D496-106 weight portion alpha- pinene oxides 105-115
Weight portion.
2. a kind of pharmaceutical composition for treating cerebral thrombus according to claim 1, it is characterised in that be made the pharmaceutical composition
Bulk drug composition and weight portion be：
The weight portion bromination of 2375 weight portion lightyellow sophora seed of climbing seedbox herb 6575 weight portion mongolian jurinea tomentum, 7475 weight portion thickfruit millettia seed or fruit 1675
The weight portion of choline -1,1,2,2-D4101 weight portion alpha- pinene oxides 110.
3. a kind of pharmaceutical composition for treating cerebral thrombus according to claim 1, it is characterised in that pharmaceutical composition can be adopted
Piece agent or capsule or dripping pill are prepared with the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for treating cerebral thrombus according to claim 1, it is characterised in that pharmaceutical composition and chemistry
The treatment cerebral thrombus medicine of medicine or Chinese medicine composition.
5. a kind of preparation method of the pharmaceutical composition for treating cerebral thrombus, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：The weight portion of the weight portion of climbing seedbox herb 6525-6625 mongolian jurinea tomentum 7425-7525 hardship wingceltis
Sub weight portion choline bromide-1,1,2,2-D496-106 weight portion of 2325-2425 weight portion lightyellow sophora seed 1625-1725
The weight portion of alpha- pinene oxides 105-115；
Preparation method：
（1）By bulk drug proportioning water intaking cloves, mongolian jurinea tomentum, thickfruit millettia seed or fruit, lightyellow sophora seed, choline bromide -1,1,2,2-D4, alpha- pinanes
Olefinic oxide, mixes, and with the ethanol of weight percent concentration 34% as solvent, is taken in 44 DEG C of temperature extractions, and extraction time is 7 times, often
Secondary extraction time is 26 hours, and each solvent load is 46 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, is carried
Take liquid A and reclaim ethanol, be concentrated into relative density 1.16, filter, liquid is first washed with water by LSA-40 large pore resin absorption columns
It is de-, then LSA-40 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 59%, collect weight percent concentration
59% ethanol eluate, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 41% as solvent, heating and refluxing extraction 4 times is carried every time
The time is taken for 1.4 hours, each solvent load is 14 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use weight by DM11 large pore resin absorption columns
The ethanol solution of percent concentration 64% elutes DM11 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 64%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for treating cerebral thrombus according to claim 5, it is characterised in that by as follows
It is prepared by step：
The composition and weight portion of bulk drug be：The weight portion of 6575 weight portion mongolian jurinea tomentum of climbing seedbox herb, 7475 weight portion thickfruit millettia seed or fruit 2375
The weight portion of 1675 weight portion choline bromide -1,1,2,2-D4101 weight portion alpha- pinene oxides of lightyellow sophora seed 110；
Preparation method：
（1）By bulk drug proportioning water intaking cloves, mongolian jurinea tomentum, thickfruit millettia seed or fruit, lightyellow sophora seed, choline bromide -1,1,2,2-D4, alpha- pinanes
Olefinic oxide, mixes, and with the ethanol of weight percent concentration 34% as solvent, is taken in 44 DEG C of temperature extractions, and extraction time is 7 times, often
Secondary extraction time is 26 hours, and each solvent load is 46 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, is carried
Take liquid A and reclaim ethanol, be concentrated into relative density 1.16, filter, liquid is first washed with water by LSA-40 large pore resin absorption columns
It is de-, then LSA-40 large pore resin absorption columns are eluted with the ethanol solution of weight percent concentration 59%, collect weight percent concentration
59% ethanol eluate, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 41% as solvent, heating and refluxing extraction 4 times is carried every time
The time is taken for 1.4 hours, each solvent load is 14 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use weight by DM11 large pore resin absorption columns
The ethanol solution of percent concentration 64% elutes DM11 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 64%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for treating cerebral thrombus according to claim 5, it is characterised in that medicine group
Compound can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition for treating cerebral thrombus according to claim 5, it is characterised in that medicine group
Compound and chemical drugs or Chinese medicine composition treatment cerebral thrombus medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611134472.1A CN106822230A (en) | 2016-12-10 | 2016-12-10 | Treat pharmaceutical composition of cerebral thrombus and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611134472.1A CN106822230A (en) | 2016-12-10 | 2016-12-10 | Treat pharmaceutical composition of cerebral thrombus and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106822230A true CN106822230A (en) | 2017-06-13 |
Family
ID=59140577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611134472.1A Withdrawn CN106822230A (en) | 2016-12-10 | 2016-12-10 | Treat pharmaceutical composition of cerebral thrombus and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106822230A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596843A (en) * | 2016-01-25 | 2016-05-25 | 济南星懿医药技术有限公司 | Medicine composition for treating cerebral thrombosis and preparation method thereof |
| CN106038756A (en) * | 2016-07-01 | 2016-10-26 | 济南星懿医药技术有限公司 | Pharmaceutical composition capable of treating cerebral thrombosis and preparation method of pharmaceutical composition |
-
2016
- 2016-12-10 CN CN201611134472.1A patent/CN106822230A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596843A (en) * | 2016-01-25 | 2016-05-25 | 济南星懿医药技术有限公司 | Medicine composition for treating cerebral thrombosis and preparation method thereof |
| CN106038756A (en) * | 2016-07-01 | 2016-10-26 | 济南星懿医药技术有限公司 | Pharmaceutical composition capable of treating cerebral thrombosis and preparation method of pharmaceutical composition |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101990975B (en) | Chinese pagodatree tea and preparation method | |
| CN106668348A (en) | Pharmaceutical composition for treating diabetic retinopathy | |
| CN106822230A (en) | Treat pharmaceutical composition of cerebral thrombus and preparation method thereof | |
| CN105194298A (en) | Traditional Chinese medicine oral solution for treating coronary heart diseases and preparation method of traditional Chinese medicine oral solution | |
| CN104800464A (en) | Traditional Chinese medicine for treating urticaria | |
| CN104524359B (en) | A kind of Chinese medicine composition, its preparation method and application | |
| CN103349709B (en) | Traditional Chinese medicine preparation capable of tonifying qi and yin and nourishing liver and kidney | |
| CN106540011A (en) | The pharmaceutical composition of preventing and treating senile osteoporosis | |
| CN107693621A (en) | Chinese medicine and its preparation for coronary heart disease myocardial infarction treatment | |
| CN106539842A (en) | Prevent and treat tonsillitic pharmaceutical composition and preparation method thereof | |
| CN105641016A (en) | Pharmaceutical composition for treating coronary heart disease | |
| CN105106817A (en) | Yao medicine compound broadleaf globethistle inflorescence tablet for treating diabetes and preparation method thereof | |
| CN106822261A (en) | Prevent and treat pharmaceutical composition of neurodermatitis and preparation method thereof | |
| CN104147433A (en) | Traditional Chinese medicine used for treating hyperthyroidism | |
| CN106692512A (en) | Pharmaceutical composition capable of preventing and treating uterine fibroid | |
| CN115814020A (en) | Traditional Chinese medicine composition for treating ventricular arrhythmia and application thereof | |
| CN103550284A (en) | Traditional Chinese medicine composition for treating urinary calculus and preparation method thereof | |
| CN106581326A (en) | Pharmaceutical composition for preventing and treating senile osteoporosis | |
| CN106668183A (en) | Pharmaceutical composition for treating epilepsy and preparation method thereof | |
| CN107714954A (en) | A kind of Chinese medicine for treating hypertension | |
| CN108403902A (en) | A kind of Chinese medicine composition for treating hypertension and its complication | |
| CN106619771A (en) | Medicine compositionc for preventing and treating hysteromyoma | |
| CN106727878A (en) | It is a kind of to treat pharmaceutical composition of cerebral thrombus and preparation method thereof | |
| CN106581102A (en) | Pharmaceutical composition for treatment of uterine myoma | |
| CN106728512A (en) | It is a kind of to prevent and treat pharmaceutical composition of osteoporosis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170613 |