CN105596497A - Pharmaceutical composition for treating pancreatitis - Google Patents

Pharmaceutical composition for treating pancreatitis Download PDF

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Publication number
CN105596497A
CN105596497A CN201610047037.9A CN201610047037A CN105596497A CN 105596497 A CN105596497 A CN 105596497A CN 201610047037 A CN201610047037 A CN 201610047037A CN 105596497 A CN105596497 A CN 105596497A
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pharmaceutical composition
root
pancreatitic
bulk drug
leech
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不公告发明人
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Jinan Xingyi Medical Technology Co Ltd
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Jinan Xingyi Medical Technology Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a pharmaceutical composition for treating pancreatitis and a preparing method thereof. The pharmaceutical composition is prepared through matching of rosette thistle herb, rhizoma coptidis, radix paeoniae alba, leech, radix gentianae, rhizoma corydalis, radix bupleuri, dried tangerine or orange peel, radix angelica sinensis, spica prunellae, herba sedi, cordyceps sinensis and dandelion. The pharmaceutical composition can be made into various dosage forms according to the conventional preparation technology, and the pancreatitis curative effect is remarkable.

Description

One is treated pancreatitic pharmaceutical composition
Technical field
The invention belongs to technical field of traditional Chinese medicines, relate in particular to one and treat pancreatitic pharmaceutical composition and preparation side thereofMethod.
Background technology
Pancreatitis is the disease that pancreas causes because of tryptic autodigestion effect. Pancreas has oedema, hyperemia, or hemorrhage,Downright bad. There is clinically stomachache, abdominal distension, feel sick, the symptom such as vomiting, heating. Amylase content rising etc. in blood test and urine, canBe divided into acute and chronic two kinds. Pancreas is the second largest digestion body of gland of human body, is the organ that digestion is the strongest. The pancreas that it is secretedLiquid is the most important digestive juice of human body. Under normal circumstances, pancreatic juice contains the pancreas that inertia is non-activity in its gland tissueProenzyme. Pancreatic juice constantly flows into duodenum through choledochus Oddi's sphincter along pancreas pipeline, owing to there being courage in duodenumJuice exists, and adds that duodenal wall mucous membrane secretes a kind of enterokinase, and under the effect of the two, pancreatin is former starts to be transformed into activity veryStrong digestive ferment. If efferent tract is obstructed, drainage difficulty, can cause pancreatitis.
Tradition western medicine pancreatitis is generally with antibiotic and to apply hormone be main, just cures the symptoms, not the disease; Operation is controlledTreat inevasible meeting and cause wound. Light nutritious to eat at ordinary times, the food of liquid, as thin rice gruel, vegetable soup, lotus root starch, egg flower soup,Dough sheet etc.; Except liquid food, also comprise that congee, vegetarian noodles life, plain vermicelli, plain won ton, bread, fruit etc. are main, on diet and life allBring serious inconvenience. The medicine of now treating cholecystitis mainly contains: clear pancreas choleretic granules, pancreas dan shu capsule, the scorching mixture of pancreas courage, mattressMountain lotus particle etc. Although these medicines have certain curative effect, but still can not be satisfactory.
Rosette thistle herb: this product is feverfew rosette thistle herb Cirsiumesculentum(Sievers) C.A.Mey. dryDry root and stem tuber. Excavate autumn, removes fibrous root and impurity, dries in the shade. Sweet, cool. There is apocenosis, eliminate the phlegm, callus, disappear " very breathe out " itEffect. For pulmonary abscess, tuberculosis, phlegm prolongs unfavorable, cough, sore, " very breathing out ".
The coptis: this product is ranunculaceae plant coptis CoptischinensisFranch., triangle leaf coptis CoptisDeltoideaC.Y.ChengetHsiao or cloud connect the dry rhizome of CoptisteetaWall.. Above three kinds of differencePractise and claim " taste connects ", " refined company ", " cloud connects ". Excavate autumn, removes fibrous root and silt, dry, hits residual fibrous root. [proterties] tasteCompany: gather cluster, often bending, shape is as shank more, and single ramose root stem is grown 3～6cm, diameter 0.3～0.8cm. Surface lark or HuangBrown, coarse, there are irregular nodular pattern protuberance, fibrous root and fibrous root residue, some internode surface smoothings, as cane, are practised and are claimed " mistakeBridge ". The how residual brown scale leaf in top, remaining stem or petiole are often left in top. Matter is hard, and section is irregular, skin zone orange red orBurgundy, woody part foresythia or orange-yellow, is radial arrangement, the hollow that marrow has. Gas is micro-, and taste is extremely bitter. [nature and flavor] hardship, cold.[return through] thoughts of returning home, spleen, stomach, liver, courage, large intestine channel. [function cures mainly] heat-clearing and damp-drying drug, purging intense heat and detonicating. Full for damp and hot ruffian, vomitingAcid regurgitation, rushes down dysentery, jaundice, and unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head is told nosebleed, hot eyes, toothache, quenches one's thirst, the carbuncle furunculosis that swells; OutwardControl eczema, wet sore, duct is suppurated. The kind clear part of the body cavity above the diaphragm housing the heart and lungs of prepared RHIZOMA COPTIDIS with vino is burning hot. For hot eyes, aphtha. Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach and stomach preventing or arresting vomiting. Be used forFever and chills are tied mutually, damp and hot middle resistance, and ruffian is completely vomitted. The easypro liver of the cornel coptis and stomach preventing or arresting vomiting. For liver-stomach disharmony, vomiting acid regurgitation. Record in" Chinese pharmacopoeia ".
The root of herbaceous peony: this product is the dry root of ranunculaceae plant Chinese herbaceous peony PaeonialactifloraPall.. Summer, Qiu ErjiExcavate, clean, remove end to end and radicula, put after removing crust or peeling after boiling in boiling water and boil again, dry. [proterties] this product isCylindrical, straight or slightly bending, two ends are truncate, long 5～18cm, diameter 1～2.5cm. Surface off-white color or light red brown, bright and cleanOr have vertical wrinkle and radicula trace, occasionally there is remaining sepia crust. Matter is solid, not frangibility, and section is more smooth, off-white color or micro-Band brownish red, cambium ring is obvious, ray irradiation shape. Gas is micro-, mildly bitter flavor, acid. [nature and flavor] are bitter, sour, are slightly cold. [return through] returnsLiver, the spleen channel. [function cures mainly] flat liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating. Be used for having a headache dizzy, hypochondriac pain, stomachache, four limbs contractionBitterly, the deficiency of blood is sallow, irregular menstruation, spontaneous perspiration, night sweat. Record in " Chinese pharmacopoeia ".
Leech: this product is Hirudinidae animal whitmania WhitmaniapigraWhitman, leech HirudonipponicaThe dry body of Whitman or willow leaf leech Whit-maniaacranulataWhitman. Summer, Qiu Erji catch, and use boiling waterScald extremely, dry or low temperature drying. [proterties] leech: be flat spindle, have most links, long 4～10cm, wide 0.5～2cm.Back pitchy or dark brown, slightly protuberance, with after water logging, visible black color spot is lined up 5 longitudinal grins; The outside of belly is smooth, brown color. TwoSide brown color, front end is point slightly, the blunt circle in rear end, each tool 1 sucker in two ends, anterior sucker is not showing, and posterior sucker is larger. Matter is crisp, frangibility,Section colloidal substance. The micro-raw meat of gas. [nature and flavor] are salty, bitter, flat; Slightly poisonous. [return through] returns Liver Channel. [function cures mainly] breaks blood, by the stasis of blood,Stimulate the menstrual flow. For abdominal mass lump in the abdomen, blood stasis is through closing, injury from falling down. Record in " Chinese pharmacopoeia ".
Felwort: this product is gentianaceae plant bar leaf rough gentian GentianamanshuricaKitag., rough gentianGentianascabraBunge, three flower rough gentian Gentianatriflorapall or hard rough gentian GentianaRigescensFranch. dry root and rhizome. First three is planted to practise and claims " rough gentian ", and rear a kind of habit claims " hard rough gentian ". Spring, autumn twoSeason excavates, cleaning, drying. [proterties] rough gentian: rhizome is irregular bulk, long 1～3cm, diameter 0.3～1cm; Surface is darkTaupe brown or dark-brown, there are stem trace or residual stem foot in upper end, raw most elongated root around with lower end. Root is cylindrical, slightly turns roundSong, long 10～20cm, diameter 0.2～0.5cm; Faint yellow or the yellowish-brown in surface, the horizontal wrinkle showing is arranged at top more, and bottom isCarefully, there are vertical wrinkle and supporting root trace. Matter is crisp, frangibility, and section is slightly smooth, skin zone's yellow-white or fallow, woody part look more shallow, isPoint-like circular row. Gas is micro-, and taste is very bitter. [nature and flavor] hardship, cold. [return through] returns liver, gallbladder channel. [function cures mainly] heat-clearing and damp-drying drug, purging the liver of pathogenic fire courageFire. For jaundice with damp-heat pathogen, swelling of vulva pruritus vulvae, under band, persistent erection, eczema itch, hot eyes, deafness, hypochondriac pain, bitter taste, convulsion. RecordIn " national Chinese herbal medicine compilation ".
Prolong recklessly: this product is the dry tuber of papaveraceae plant corydalis CorydalisyanhusuoW.T.Wang.When early summer cauline leaf is withered, excavate, remove fibrous root, clean, put in boiling water, to boil to proper and during without the white heart, take out, dry. [proterties] this productBe irregular oblate spheroid, diameter 0.5～1.5cm. Surface yellow or yellowish-brown, have irregular netted wrinkle. Top has slightly recessedSunken stem trace, pimple shape projection is often arranged at bottom. Matter is hard and crisp, section yellow, and cutin sample, has wax sample gloss. Gas is micro-, bitter [propertyTaste] pungent, bitter, temperature. [return through] returns liver, the spleen channel. [function cures mainly] invigorates blood circulation, sharp gas, pain relieving. For the chest side of body, epigastric pain, warpClose dysmenorrhoea, postpartum stasis blocking, tumbling and swelling. Record in " Chinese pharmacopoeia ".
Radix bupleuri: this product is umbelliferae bupleurum BupleurumchinenseDC. or radix bupleuri scorzoneraefolii BupleurumScorzonerifoliumWilld. dry root. By proterties difference, practise respectively and claim " Bupleurum Chinese " and " RADIX BUPLEURI SCORZONERAEFOLII ". Spring, autumn twoSeason excavates, and removes cauline leaf and silt, dry. [proterties] Bupleurum Chinese: cylindrical or conico-acuminate, long 6～15cm, diameter 0.3～0.8cm. Root head expands, residual 3～15 stem foots in top or short fiber shape phyllopodium, bottom branch. Surface pitchy or shallow palm fibreLook, tool is indulged wrinkle, supporting root trace and hole skin. Matter is hard and tough, not frangibility, and section shows fibroid, skin zone's light brown, woody part is yellowish-whiteLook. The micro-perfume (or spice) of gas, mildly bitter flavor. [nature and flavor] hardship, is slightly cold. [return through] returns liver, gallbladder channel. [function cures mainly] and induce sweat in, soothing the liver, riseSun. For cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, sub-official's prolapsus, prolapse of the anus. Record in " Chinese pharmacopoeia ".
Dried orange peel: this product is being dried to of rutaceae orange CitrusreticulataBlanco and variety thereofRipe pericarp. Medicinal material is divided into " dried orange peel " and " citrus chachiensis hortorum ". Pluck ripening fruits, strip pericarp, dry or low temperature drying. [proterties]Dried orange peel: often shell into several lobes, base portion is connected, and what have is irregular sheet, thick 1～4mm. Orange red or the rufous of outer surface, hasFine wrinkle and recessed point-like grease chamber; Inner surface ivory buff, coarse, attached yellow-white or yellowish-brown grain shape vascular bundle. Matter slightlyHard and crisp. Gas perfume (or spice), taste is pungent, bitter. [nature and flavor] are bitter, pungent, temperature. [return through] returns lung, the spleen channel. [function cures mainly] regulating qi-flowing for strengthening spleen, eliminating dampnessReduce phlegm. For chest gastral cavity turgor, food is few vomits and diarrhoea, coughing with a lot of sputum. Record in " Chinese pharmacopoeia ".
Radix Angelicae Sinensis: this product is umbelliferae angelica Angelicasinensis(Oliv.) the dry root of Diels. AutumnExcavate at end, removes fibrous root and silt, after moisture slightly evaporates, is bundled into wisp, and upper canopy, with slowly smoke-dried beancurd of pyrotechnics. [proterties] this productSlightly cylindrical, 3～5 of supporting roots or are arranged more at bottom, long 15～25cm. Surface yellowish-brown is to sepia, and tool is indulged wrinkle and horizontal strokeSkin hole. Root head (returning head) diameter 1.5～4cm, tool ring grain, upper end circle is blunt, has the residue of purple or yellowish green stem and leaf sheath;Main root (returning body) surface irregularity; Supporting root (returning tail) diameter 0.3～1cm, upper coarse and lower fine, many distortions, have minority mark of fibrous root. MatterPliable and tough, section yellow-white or fallow, skin zone is thick, has crack and most brown point-like secretory cavity, and woody part look lighter, forms layerRing yellowish-brown. There is strong fragrance, sweet, pungent, the micro-hardship of taste. [nature and flavor] sweet, acrid, warm. [return through] returns liver, the heart, the spleen channel. [functionCure mainly] to enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, relaxes bowel. Sallow for the deficiency of blood, dizzy palpitaition, irregular menstruation, through closing dysmenorrhoea, the cold of insufficiency typeStomachache, the dry constipation of intestines, arthralgia due to wind-dampness, injury from falling down, ulcer sores. Prepared RADIX ANGELICAE SINENSIS with yellow rice wine activating blood to promote menstruation. Be used for through closing dysmenorrhoea rheumatism numbnessBitterly, injury from falling down. Record in " Chinese pharmacopoeia ".
Selfheal: this product is the dry fruit ear of labiate selfheal PrunellavulgarisL.. Summer fruit earWhile being brownish red, gather, remove impurity, dry. [proterties] this product is bar-shaped, slightly flat, long 1.5～8cm, and diameter 0.8～1.5cm, light brown is to brownish red. Full fringe forms by counting wheel to 10 number wheel place calyxs and bract, and every wheel 2 of raw bracts, is fanShape, tip fine stern shape, vein is obvious, and outer surface has white hair. In each bract, spend 3, how corolla comes off, place calyx bilabiateShape, inside has 4 pieces of pyrenes, and oval is brown, most advanced and sophisticated adularescent projection. Body is light. Gas is micro-, lightly seasoned. [nature and flavor] are pungent, bitter, cold.[return through] returns liver, gallbladder channel. [function cures mainly] relieves inflammation or internal heat, improving eyesight, dissipating bind, detumescence. For red eye, swell pain, order pearl nyctalgia, has a headache dizzyDizzy, scrofula, goiter and tumor, acute mastitis swells and ache; Thyroid gland enlargement, scrofula, the proliferation of mammary gland, hypertension. Record in " Chinese pharmacopoeia ".
Stringy stonecrop: this product is the fresh or dry complete of crassulaceae plants stringy stonecrop SedumsarmentosumBungeGrass. Summer, Qiu Erji gather, and remove impurity. Using fresh herb or dry. [proterties] this product stem is very thin, more than length can reach 20cm, and part jointUpper visible very thin adventitious root. 3 impellers are raw, and blade falls lanceolar to square circle, green, and meat, long 1.5～2.8cm, wide by 0.3～0.7cm, the nearly anxious point of tip, base portion is anxious narrow, has distance. Gas is micro-, mildly bitter flavor. [nature and flavor] are sweet, light, cool. [return through] return liver, courage,Small intestinl channel. [function cures mainly] eliminating dampness and heat, removing toxic substances. For jaundice with damp-heat pathogen, difficult urination, the carbuncle sore that swells, acute hepatitis, chronic hepatitis. ReceiveBe loaded in " Chinese pharmacopoeia ".
Chinese caterpillar fungus: this product is section ergot fungus cordyceps sinensis bacterium Cordycepssinensis(Berk.) Sacc. parasitismThe complex of the stroma on Hepialidae insect larvae and larva corpse. Early summer stroma is unearthed, spore takes while not dispersing, shinesTo 6 seventy percent dry, remove quasi-fibrous attachment and impurity, dry or low temperature drying. [proterties] this product is by polypide and from wormThe fungi stroma that head grows is connected and forms. Polypide is silkworm seemingly, long 3～5cm, diameter 0.3～0.8cm; Surface buff is to yellowish-brownLook, has 20～30 of ring grains, and the ring grain of nearly head is thinner; Head rufous, 8 pairs, foot, 4 pairs, middle part is more obvious; Matter is crisp, easy to breakDisconnected, section is slightly smooth, yellowish white. Stroma elongated cylindrical, long 4～7cm, diameter 0.3cm; Surface dark-brown is to brownLook, has thin vertical wrinkle, and slightly expand on top; Matter is pliable and tough, section off-white color. The micro-raw meat of gas, mildly bitter flavor. [nature and flavor] are sweet, flat. [return through]Return lung, kidney channel. [function cures mainly] invigorates the lung and the kidney, hemostasis and phlegm. Breathe heavily the labor spitting of blood of coughing, impotence and seminal emission, the acid of waist knee for chronic cough voidBitterly. Record in " national Chinese herbal medicine compilation ".
Dandelion: this product is feverfew dandelion TaraxacummongolicumHand.-Mazz., alkali ground Pu public affairsEnglish TaraxacumsinicumKitag. or belong to the dry herbs of several plants together. Spend spring to autumn while just opening and excavate, removeImpurity, cleans, and dries. [proterties] this product is the curling agglomerate of shrinkage. It is conical that root is, how bending, long 3～7cm; Surface palm fibreBrown, shirring; Root head has the fine hair of sepia or yellow-white, and what have comes off. Phyllopodium is raw, many shrinkages fragmentation, intact leafBe down lanceolar, green and brown look or lead, tip point or blunt, edge is shallow to be split or pinnation, and base portion is gradually narrow, the downward handle shape that is,Lower surface master pulse is obvious. Scape 1 is to several, every top repiece locusta, and phyllary multilayer, inner face one deck is longer, and corolla is yellowish-brownLook or yellowish white. The oblong achene of the visible most tool white pappus that have. Gas is micro-, mildly bitter flavor. [nature and flavor] are bitter, sweet,Cold. [return through] returns liver, stomach warp. [function cures mainly] is clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia. For furuncle swelling toxin, acute mastitis,Scrofula, hot eyes, pharyngalgia, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, heat is drenched puckery pain. Record in " Chinese pharmacopoeia ".
Summary of the invention
The object of the invention is to overcome the deficiency of background technology, provide a kind of effectively pancreatitic pharmaceutical composition for the treatment of andIts preparation method.
The present invention adopts following technical scheme to realize:
Composition and the weight portion of making the bulk drug of the pancreatitic pharmaceutical composition of this treatment are:
Rosette thistle herb 50-80g, coptis 20-30g, root of herbaceous peony 20-30g, leech 20-30g, felwort 30-50g, prolong recklessly 20-30g, bavin20-30g, dried orange peel 20-30g, Radix Angelicae Sinensis 10-20g, selfheal 20-30g, stringy stonecrop 20-30g, Chinese caterpillar fungus 10-20g, dandelion recklessly20-30g。
Preferably be used for the treatment of pancreatitic pharmaceutical composition, formed by the bulk drug of following weight portion:
Rosette thistle herb 60g, coptis 25g, root of herbaceous peony 25g, leech 25, felwort 40g, prolong recklessly 25g, radix bupleuri 25g, dried orange peel 25g, Radix Angelicae Sinensis15g, selfheal 25g, stringy stonecrop 25g, Chinese caterpillar fungus 15g, dandelion 25g.
One is treated pancreatitic pharmaceutical composition, it is characterized in that pharmaceutical composition can adopt the routine side of galenic pharmacyLegal system standby one-tenth tablet or capsule or dripping pill.
One is treated pancreatitic pharmaceutical composition, it is characterized in that controlling of pharmaceutical composition and chemical drugs or Chinese medicine compositionTreat pancreatitis medicine.
Treat a preparation method for pancreatitic pharmaceutical composition, it is characterized in that preparing as follows:
The composition of bulk drug and weight portion are: rosette thistle herb 50-80g, coptis 20-30g, root of herbaceous peony 20-30g, leech 20-30g, rough gentianGrass 30-50g, prolong recklessly 20-30g, radix bupleuri 20-30g, dried orange peel 20-30g, Radix Angelicae Sinensis 10-20g, selfheal 20-30g, stringy stonecrop 20-30g, Chinese caterpillar fungus 10-20g, dandelion 20-30g;
Preparation method: by bulk drug proportioning get rosette thistle herb, the coptis, the root of herbaceous peony, leech, felwort, prolong Hu, radix bupleuri, dried orange peel, Radix Angelicae Sinensis,Selfheal, stringy stonecrop, Chinese caterpillar fungus, dandelion, mix, and uses weight percent concentration 60% ethanol as solvent, 60 DEG C of warm lixiviatesGet, extraction time is 4 times, and each extraction time is 1.5 hours, and each solvent load is 12 times of bulk drug gross weight, filter,Obtain dregs of a decoction A and extract, extract reclaims ethanol, is concentrated into relative density 1.12, filters, and liquid is by LS-300 macroporous absorptionResin column, first washes with water, then uses the ethanolic solution wash-out LS-300 large pore resin absorption column of weight percent concentration 65%, receivesCollection weight percent concentration 65% ethanol eluate, reclaims ethanol, and concentrate drying, obtains pharmaceutical composition.
Preferred a kind of preparation method who treats pancreatitic pharmaceutical composition, is characterized in that preparing as follows:
The composition of bulk drug and weight portion are: rosette thistle herb 60g, coptis 25g, root of herbaceous peony 25g, leech 25, felwort 40g, prolong recklessly25g, radix bupleuri 25g, dried orange peel 25g, Radix Angelicae Sinensis 15g, selfheal 25g, stringy stonecrop 25g, Chinese caterpillar fungus 15g, dandelion 25g;
Preparation method: by bulk drug proportioning get rosette thistle herb, the coptis, the root of herbaceous peony, leech, felwort, prolong Hu, radix bupleuri, dried orange peel, Radix Angelicae Sinensis,Selfheal, stringy stonecrop, Chinese caterpillar fungus, dandelion, mix, and uses weight percent concentration 60% ethanol as solvent, 60 DEG C of warm lixiviatesGet, extraction time is 4 times, and each extraction time is 1.5 hours, and each solvent load is 12 times of bulk drug gross weight, filter,Obtain dregs of a decoction A and extract, extract reclaims ethanol, is concentrated into relative density 1.12, filters, and liquid is by LS-300 macroporous absorptionResin column, first washes with water, then uses the ethanolic solution wash-out LS-300 large pore resin absorption column of weight percent concentration 65%, receivesCollection weight percent concentration 65% ethanol eluate, reclaims ethanol, and concentrate drying, obtains pharmaceutical composition.
Treat a preparation method for pancreatitic pharmaceutical composition, it is characterized in that pharmaceutical composition can adopt preparationThe conventional method of learning is prepared into tablet or capsule or dripping pill.
Treat a preparation method for pancreatitic pharmaceutical composition, it is characterized in that pharmaceutical composition and chemical drugs or inMedicine composition treatment pancreatitis medicine.
Pharmaceutical composition combination chemotherapy pancreatitis, can obviously improve the quality of living, and extends life cycle and reduce poison secondaryThe generation of effect.
Detailed description of the invention
Embodiment 1: treat pancreatitic pharmaceutical composition and preparation method thereof
Composition and the weight portion for the treatment of the bulk drug of pancreatitic pharmaceutical composition are: rosette thistle herb 60g, coptis 25g, root of herbaceous peony 25g,Leech 25, felwort 40g, prolong recklessly 25g, radix bupleuri 25g, dried orange peel 25g, Radix Angelicae Sinensis 15g, selfheal 25g, stringy stonecrop 6g, Chinese caterpillar fungus 15g,Dandelion 25g.
Preparation method: by bulk drug proportioning get rosette thistle herb, the coptis, the root of herbaceous peony, leech, felwort, prolong Hu, radix bupleuri, dried orange peel, whenReturn, selfheal, stringy stonecrop, Chinese caterpillar fungus, dandelion, mix,, soak 60 DEG C of temperature as solvent with weight percent concentration 60% ethanolExtract, extraction time is 4 times, and each extraction time is 1.5 hours, and each solvent load is 12 times of bulk drug gross weight, filterCross, obtain dregs of a decoction A and extract, extract reclaims ethanol, is concentrated into relative density 1.12, filters, and liquid is by LS-300 macroporeAdsorption resin column, first washes with water, then uses the ethanolic solution wash-out LS-300 macroporous absorbent resin of weight percent concentration 65%Post, collects weight percent concentration 65% ethanol eluate, reclaims ethanol, and concentrate drying, obtains pharmaceutical composition.
Embodiment 2: treat pancreatitic pharmaceutical composition and preparation method thereof
Composition and the weight portion for the treatment of the bulk drug of pancreatitic pharmaceutical composition are: rosette thistle herb 50g, coptis 30g, root of herbaceous peony 20g,Leech 30g, felwort 30g, prolong recklessly 30g, radix bupleuri 20g, dried orange peel 30g, Radix Angelicae Sinensis 10g, selfheal 30g, stringy stonecrop 20g, Chinese caterpillar fungus20g, dandelion 20g.
Preparation method: by bulk drug proportioning get rosette thistle herb, the coptis, the root of herbaceous peony, leech, felwort, prolong Hu, radix bupleuri, dried orange peel, whenReturn, selfheal, stringy stonecrop, Chinese caterpillar fungus, dandelion, mix,, soak 60 DEG C of temperature as solvent with weight percent concentration 60% ethanolExtract, extraction time is 4 times, and each extraction time is 1.5 hours, and each solvent load is 12 times of bulk drug gross weight, filterCross, obtain dregs of a decoction A and extract, extract reclaims ethanol, is concentrated into relative density 1.12, filters, and liquid is by LS-300 macroporeAdsorption resin column, first washes with water, then uses the ethanolic solution wash-out LS-300 macroporous absorbent resin of weight percent concentration 65%Post, collects weight percent concentration 65% ethanol eluate, reclaims ethanol, and concentrate drying, obtains pharmaceutical composition.
Embodiment 3: treat pancreatitic pharmaceutical composition and preparation method thereof
Composition and the weight portion for the treatment of the bulk drug of pancreatitic pharmaceutical composition are: rosette thistle herb 80g, coptis 20g, root of herbaceous peony 30g,Leech 20g, felwort 50g, prolong recklessly 20g, radix bupleuri 30g, dried orange peel 20g, Radix Angelicae Sinensis 20g, selfheal 20g, stringy stonecrop 30g, Chinese caterpillar fungus10g, dandelion 30g.
Preparation method: by bulk drug proportioning get rosette thistle herb, the coptis, the root of herbaceous peony, leech, felwort, prolong Hu, radix bupleuri, dried orange peel, whenReturn, selfheal, stringy stonecrop, Chinese caterpillar fungus, dandelion, mix,, soak 60 DEG C of temperature as solvent with weight percent concentration 60% ethanolExtract, extraction time is 4 times, and each extraction time is 1.5 hours, and each solvent load is 12 times of bulk drug gross weight, filterCross, obtain dregs of a decoction A and extract, extract reclaims ethanol, is concentrated into relative density 1.12, filters, and liquid is by LS-300 macroporeAdsorption resin column, first washes with water, then uses the ethanolic solution wash-out LS-300 macroporous absorbent resin of weight percent concentration 65%Post, collects weight percent concentration 65% ethanol eluate, reclaims ethanol, and concentrate drying, obtains pharmaceutical composition.
Embodiment 4: the preparation of tablet
Get embodiment 1 pharmaceutical composition 80g, add starch 60g, mix, granulate, dry, add microcrystalline cellulose 10g, stearic acidMagnesium 1g, mixes, and is pressed into 1000, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Get embodiment 2 pharmaceutical composition 80g, add starch 70g, mix, granulate, dry, whole grain, adds appropriate dolomol,Mix, encapsulated 1000, obtain medicament composition capsule.
Embodiment 6: the preparation of dripping pill
Take Macrogol 6000 180g water-bath (80 DEG C) heating and boil moltenly, add embodiment 3 pharmaceutical composition 30g, fully stirMix evenly, taking atoleine as cooling agent, put in glass tube (4*80cm), chilling temperature is 8 DEG C, and drip internal-and external diameter is 7.0/2.0 (mm/mm), drip is 1.5cm apart from liquid level, drips speed taking 50 of per minutes as optimum condition, blots the cold of dripping pill surface with cottonSolidifying agent, obtains medicament composition dropping pills.
Experimental example 1: treat pancreatitic experimental study
1 data and method
1.1 physical data
This is studied selected 100 routine cases and all controls in hospital during in May, 2012～2013 year May from institute of traditional Chinese medicine of Shandong ProvinceThe patient who treats, comprises male patient's 50 examples, female patient 50 examples, 25～80 years old age, 56.6 ± 16.33 years old mean age. RootAccording to clinical manifestation, be divided into mild acute pancreatitis (MAP) 58 examples, moderate Severe Acute Pancreatitis SAP (MSAP) 35 examples, severe pancreasScorching (SAP) 7 examples. Patient is equally divided into two groups, each 50 examples for the treatment of group and control group, treatment group man 26 examples, female's 24 examples, average year54.23 ± 18.68 years old age, MAP30 example, MSAP15 example, SAP5 example, control group man 24 examples, female's 26 examples, the mean age 55.5 ±18.17 years old, MAP28 example, MSAP20 example, SAP2 example, two groups of patients no significant difference aspect age, sex, clinical classification, P> 0.05, has good comparativity.
1.2 methods for the treatment of
Two groups of patients all carry out conventional monitoring, fasting, gastrointestinal decompression, liquid resuscitation, respiratory function support, anti-infective, analgesia etc.Treatment.
1.2.1 control group
Control group gives UTI and gives for the first time 10-20 ten thousand U/d, is dissolved in the fluid injection of 500ml5% glucose or 0.9% physiology saltWater injection iv drip, each quiet 1～2h, every day 1～3 time, the decrement with resolution of symptoms later, until symptom andSign disappears, and blood, amylase in urine are normal. Also can each 10～200,000 U crows for Severe Acute Pancreatitis SAP circulatory failure patientSi Tading is dissolved in slow intravenous injection in 2mL physiological saline, every 1～3 time.
1.2.2 treatment group
The same control group of therapeutic scheme adds pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20110103) simultaneously, each1.5g, take every day for 2 times, serve on 3 weeks.
1.3.1 observation index
Observe stomachache, abdominal distension remission time after two groups of patient's begin treatments, blood, amylase in urine drop to normal time, after 3 weeksEfficacy evaluation.
1.3.2 statistical method
Use SPSS19.0 to analyze, measurement data is used x ± s to represent, carry out t inspection, enumeration data is carried out χ2Inspection, P <0.05 has statistical significance.
2. treatment results
2.1 efficacy evaluation
Treat after 3 weeks, two groups of patients are all without death, effective 20 examples for the treatment of group, effective 28 examples, invalid 2 examples, total effective rateBe 96%, effective 16 examples of control group, effective 20 examples, invalid 14 examples, total effective rate is 72%, two group of comparison (P < 0.05) meaning.
2.2 observation index
Treatment group abdominal distension, stomachache extinction time are shorter than control group, significant difference, and blood, amylase in urine recovery time is for control group,Significant difference, all has statistical significance (P < 0.05), in table 1.
Two groups of patient's observation index comparison (d) after table 1 treatment
Note: with control group comparison,△P＜0.05。
Experimental example 2: model case
Example 1: square XX, man, 42 years old. On July 7th, 2012 is because eating and drinking immoderately, approximately 11 o'clock that night because of acute abdominalgia emergency hospitalization, westDoctor is diagnosed as acute pancreatitis. After treatment, within 10th, require the traditional Chinese medical science consultation of doctors. This patient's sallow complexion, the gastral cavity side of body as the acupuncture sample that lancinatesPain, enter a small amount of semiliquid diet also abdominal distension want to tell, a line on the 3rd～4 of defecating, amount less and half congealed smelly. Tongue thick,yellow and greasy fur, tongue limit point is redAnd have tooth to print, deep thready pulse. B ultrasonic shows that head of pancreas is fuzzyyer around, examines and has muddy stone concurrently for chronic cholecystitis. This is that gluttony is indulged inWine, damp and hot pent-up is in liver and gall taste, disturbance in ascending and descending. The therapeutic scheme adopting is as follows: take the above embodiment of the present invention 1 and prepare medicineCompositions (lot number 20110103), each 1.5g, every day 2 times, serve on rear recovery from illness in 4 weeks and leaves hospital.
Example 2: white XX, female, 56 years old, first visit on September 12 in 2010. Element body obesity, suffered from chronic cholecystitis, cholelithiasis before 1 year,Because repeatedly showing effect in row cholecystectomy on August 17th, 2009, recover after normal to leave hospital, after half a year, gradually feel that because of tired gastral cavity abdomen doesSwollen, when the middle part of gastric cavity, there is shouting pain and draw and left flank, to take food very greasy, large loose stool is smelly. On July 9th, 2012 because of upper abdomen the pain increased,N and V and being in hospital. Serum amylase is 229 μ (Xi Shi methods), and CT shows head of pancreas about 4～5cm place fog around, is diagnosed asChronic pancreatitis. Improve the not obvious Chinese traditional treatment that requires through doctor trained in Western medicine expectant treatment symptom. The therapeutic scheme adopting is as follows: take thisInvention above-described embodiment 1 pharmaceutical compositions (lot number 20110103), each 1.5g, every day 2 times, fully recovers after serveing on 5 weeksInstitute.

Claims (7)

1. the pancreatitic pharmaceutical composition for the treatment of, is characterized in that the composition of the bulk drug of making this pharmaceutical composition and weighsAmount part is:
Rosette thistle herb 50-80g, coptis 20-30g, root of herbaceous peony 20-30g, leech 20-30g, felwort 30-50g, prolong recklessly 20-30g, bavin20-30g, dried orange peel 20-30g, Radix Angelicae Sinensis 10-20g, selfheal 20-30g, stringy stonecrop 20-30g, Chinese caterpillar fungus 10-20g, dandelion recklessly20-30g。
2. one is treated pancreatitic pharmaceutical composition according to claim 1, it is characterized in that making this pharmaceutical compositionComposition and the weight portion of bulk drug be:
Rosette thistle herb 60g, coptis 25g, root of herbaceous peony 25g, leech 25g, felwort 40g, prolong recklessly 25g, radix bupleuri 25g, dried orange peel 25g, Radix Angelicae Sinensis15g, selfheal 25g, stringy stonecrop 25g, Chinese caterpillar fungus 15g, dandelion 25g.
3. one is treated pancreatitic pharmaceutical composition according to claim 1, it is characterized in that pharmaceutical composition can adoptBe prepared into tablet or capsule or dripping pill by the conventional method of galenic pharmacy.
4. one is treated pancreatitic pharmaceutical composition according to claim 1, it is characterized in that pharmaceutical composition and chemistryThe treatment pancreatitis medicine of medicine or Chinese medicine composition.
5. treat a preparation method for pancreatitic pharmaceutical composition, it is characterized in that preparing as follows:
The composition of bulk drug and weight portion are: rosette thistle herb 50-80g, coptis 20-30g, root of herbaceous peony 20-30g, leech 20-30g, rough gentianGrass 30-50g, prolong recklessly 20-30g, radix bupleuri 20-30g, dried orange peel 20-30g, Radix Angelicae Sinensis 10-20g, selfheal 20-30g, stringy stonecrop 20-30g, Chinese caterpillar fungus 10-20g, dandelion 20-30g;
Preparation method: by bulk drug proportioning get rosette thistle herb, the coptis, the root of herbaceous peony, leech, felwort, prolong Hu, radix bupleuri, dried orange peel, Radix Angelicae Sinensis,Selfheal, stringy stonecrop, Chinese caterpillar fungus, dandelion, mix, and uses weight percent concentration 60% ethanol as solvent, 60 DEG C of warm lixiviatesGet, extraction time is 4 times, and each extraction time is 1.5 hours, and each solvent load is 12 times of bulk drug gross weight, filter,Obtain dregs of a decoction A and extract, extract reclaims ethanol, is concentrated into relative density 1.12, filters, and liquid is by LS-300 macroporous absorptionResin column, first washes with water, then uses the ethanolic solution wash-out LS-300 large pore resin absorption column of weight percent concentration 65%, receivesCollection weight percent concentration 65% ethanol eluate, reclaims ethanol, and concentrate drying, obtains pharmaceutical composition.
6. a kind of preparation method who treats pancreatitic pharmaceutical composition according to claim 5, is characterized in that by as followsStep preparation:
The composition of bulk drug and weight portion are: rosette thistle herb 60g, coptis 25g, root of herbaceous peony 25g, leech 25, felwort 40g, prolong recklessly25g, radix bupleuri 25g, dried orange peel 25g, Radix Angelicae Sinensis 15g, selfheal 25g, stringy stonecrop 25g, Chinese caterpillar fungus 15g, dandelion 25g;
Preparation method: by bulk drug proportioning get rosette thistle herb, the coptis, the root of herbaceous peony, leech, felwort, prolong Hu, radix bupleuri, dried orange peel, Radix Angelicae Sinensis,Selfheal, stringy stonecrop, Chinese caterpillar fungus, dandelion, mix, and uses weight percent concentration 60% ethanol as solvent, 60 DEG C of warm lixiviatesGet, extraction time is 4 times, and each extraction time is 1.5 hours, and each solvent load is 12 times of bulk drug gross weight, filter,Obtain dregs of a decoction A and extract, extract reclaims ethanol, is concentrated into relative density 1.12, filters, and liquid is by LS-300 macroporous absorptionResin column, first washes with water, then uses the ethanolic solution wash-out LS-300 large pore resin absorption column of weight percent concentration 65%, receivesCollection weight percent concentration 65% ethanol eluate, reclaims ethanol, and concentrate drying, obtains pharmaceutical composition.
7. a kind of preparation method who treats pancreatitic pharmaceutical composition according to claim 5, is characterized in that medicine groupCompound can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or dripping pill.
CN201610047037.9A 2016-01-25 2016-01-25 Pharmaceutical composition for treating pancreatitis Withdrawn CN105596497A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105998089A (en) * 2016-07-05 2016-10-12 青海珠峰冬虫夏草工程技术研究有限公司 Application of caterpillar fungus to preparation of medicine for preventing and/or treating pancreatic fibrosis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105998089A (en) * 2016-07-05 2016-10-12 青海珠峰冬虫夏草工程技术研究有限公司 Application of caterpillar fungus to preparation of medicine for preventing and/or treating pancreatic fibrosis
CN105998089B (en) * 2016-07-05 2020-07-21 青海珠峰冬虫夏草工程技术研究有限公司 Application of cordyceps sinensis in preparation of medicine for preventing and/or treating pancreatic fibrosis

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