CN115120684B - Chinese medicinal composition for treating diabetes and its preparation method - Google Patents
Chinese medicinal composition for treating diabetes and its preparation method Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine formula for treating diabetes and a processing method thereof. The traditional Chinese medicine formula disclosed by the invention is prepared from the following raw materials in parts by weight: 5-15 parts of barley seedlings, 1-3 parts of rape seedlings, 1-3 parts of mulberry leaves, 2-6 parts of rhizoma polygonati, 3-8 parts of gynostemma pentaphylla, 2-6 parts of astragalus membranaceus, 2-6 parts of Chinese yam, 1-3 parts of ginseng, 1-2 parts of dogwood and 1-2 parts of radix ophiopogonis. The traditional Chinese medicine powder for treating diabetes is prepared by processing the formula, and can enhance insulin sensitivity of patients, promote insulin secretion and improve glycolipid metabolism; replace partial hypoglycemic drugs, reduce the accumulated toxic and side effects caused by long-term use of hypoglycemic drugs by the T2DM population; improving insulin resistance and reducing apoptosis of islet beta cells; inhibiting oxidative stress and inflammatory reaction, and delaying or relieving the development of complications; reducing the economic burden of long-term diabetes family social treatment of patients, reducing the death rate of diabetes and prolonging the health life of diabetes patients.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine formula for treating diabetes and a processing method thereof.
Background
In recent years, the prevalence of diabetes in China is gradually rising. The investigation data shows that: the number of Chinese diabetic patients in 2019 is about 1.16 hundred million people, and China has become the country with the largest number of people suffering from diabetes worldwide; at the same time, the number of diabetics is still growing rapidly. The number of people suffering from Chinese diabetes in 2040 years is predicted to reach 1.51 hundred million people. Diabetes is a group of metabolic diseases characterized by chronic hyperglycemia due to multiple causes, due to defects in insulin secretion and/or utilization. Long-term carbohydrate, fat and protein metabolism disorder can cause multisystem damage, and cause chronic progressive lesions, hypofunction and failure of tissues and organs such as eyes, kidneys, nerves, heart, blood vessels and the like, and the current treatment of diabetes is a comprehensive management process, and needs simultaneous promotion of diet, exercise, medicine, blood sugar monitoring and health education. If not treated in time, blood sugar fluctuation can cause damage to organism organs and accelerate the occurrence of complications. Diabetes is a life-long disease, most of the clinical medical level can not eradicate and cure at present, life-long drug treatment is needed, blood sugar is controlled by using hypoglycemic drugs or insulin injection, the occurrence of complications is delayed, the number of drugs is presented with increasing trend along with the treatment time, and the toxic and side effects after long-term drug administration are also statistically increased.
However, the existing medicines for treating diabetes have the following defects: 1. hypoglycemic response: the hypoglycemic response can cause severe irreversible damage to the nervous system and even death; 2. sulfonylureas produce metabolic and nutritional disorders, and damage to the nervous system; a-glycosidase inhibitor and biguanide drug produce gastrointestinal adverse reaction; 4. the duration of the pharmacokinetics is limited, and the hypoglycemic medicine needs to be taken for a long time to control blood sugar; 5. toxic and side effects of liver and kidney function metabolism. There is therefore a need to further develop effective drugs for the treatment of diabetes.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a traditional Chinese medicine formula for treating diabetes and a processing method thereof.
The technical scheme adopted for solving the technical problems is as follows:
the invention aims at providing a traditional Chinese medicine formula for treating diabetes, which is prepared from the following raw materials in parts by weight: 5-15 parts of barley seedlings, 1-3 parts of rape seedlings, 1-3 parts of mulberry leaves, 2-6 parts of rhizoma polygonati, 3-8 parts of gynostemma pentaphylla, 2-6 parts of astragalus membranaceus, 2-6 parts of Chinese yam, 1-3 parts of ginseng, 1-2 parts of dogwood and 1-2 parts of radix ophiopogonis. The weight parts of the raw materials are the weight parts of the dried raw materials.
Preferably, the formula is prepared from the following raw materials in parts by weight: 10 parts of barley seedlings, 2 parts of rape seedlings, 2 parts of mulberry leaves, 3 parts of rhizoma polygonati, 5 parts of gynostemma pentaphylla, 3 parts of astragalus membranaceus, 3 parts of Chinese yam, 2 parts of ginseng, 1 part of dogwood and 1 part of radix ophiopogonis.
Among the above drugs:
rape seedlings: cool in nature, sweet in flavor, entering liver, spleen and lung meridians. Can promote stagnancy and activate blood, reduce swelling and detoxify. Can be used for relieving qi-breaking detumescence, gastralgia, neuralgia, and head congestion, wherein the rape seedling is rape with a height of 15-30 cm.
Barley seedling: the barley straw contains polysaccharide and cellulose. Sweet and bitter taste, warm nature, no toxicity, and spleen and lung meridian entered, and has the functions of detumescence, diuresis, qi-regulating, and blood sugar reducing effects in preliminary animal experiments.
Mulberry leaf: it enters lung and liver meridians. The fine file and the large kettle are decocted to obtain erythrose, which can be used for removing old wind and blood, and has the function of reducing blood sugar.
Rhizoma polygonati: also known as: rhizoma polygonati, yellow chicken dish, pennywort herb, radix polygonati officinalis, rhizoma zingiberis, and radix polygonati officinalis. Is a Polygonatum plant, the rhizome is transverse, cylindrical and the nodule is enlarged. She Lunsheng, no handle. The medicinal plants are sweet in taste and flat in nature, and can enter spleen, lung and kidney channels, and have the effects of tonifying qi and yin, strengthening spleen, moistening lung and promoting fluid production, tonifying kidney and the like.
Gynostemma pentaphylla: the cucurbitaceae family, gynostemma herb plant climbing; the stems are thin and weak, have branches, have longitudinal edges and grooves, and have no hair or loose and short soft hair; slightly sweet, cool in nature, and good in lung, spleen and kidney meridians, and has the effects of replenishing qi to invigorate the spleen, resolving phlegm to arrest cough, clearing heat and detoxicating, reducing blood glucose and the like.
Radix astragali: sweet taste and slightly warm nature; the Chinese medicinal composition has the functions of strengthening the immunity of organisms, protecting the liver, promoting urination, resisting aging and stress, reducing blood pressure, regulating blood sugar and resisting bacteria, and has the functions of strengthening the lung, spleen, liver and kidney channels and has the history of over 2000 years so far.
Chinese yam: sweet in flavor and neutral in nature. The Chinese medicinal composition has the effects of invigorating spleen, nourishing stomach, promoting salivation, tonifying lung, invigorating kidney, astringing essence, clearing heat and detoxicating, and is used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency cough, kidney essence deficiency, spermatorrhea, leukorrhagia, frequent urination, and diabetes due to deficiency heat.
Ginseng: entering spleen and lung meridians, reinforcing primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, and tranquilizing mind, and is mainly used for: deficiency of body, loss of appetite, weak cold limbs, spleen deficiency, thirst due to body fluid deficiency, internal heat, diabetes, and deficiency of both long-term illness and deficiency of qi. The root contains ginsenoside 0.4% and small amount of volatile oil.
Fructus Corni: the dogwood has slight warmth and enters liver and kidney channels, has the effects of tonifying liver and kidney, astringing essence and securing collapse, is clinically used for internal heat diabetes, dizziness and tinnitus, soreness of waist and knees and the like, is a traditional medicinal material commonly used in clinical practice of traditional Chinese medicine, and can increase insulin secretion and increase insulin content.
Radix Ophiopogonis: sweet and slightly bitter in flavor and slightly cold in nature. The modern pharmacological research also shows that the ophiopogon root mainly contains ophiopogon root glycoside, steroid saponin, alkaloid, sitosterol, glucose, amino acid, vitamin and the like, and has the functions of resisting fatigue, scavenging free radicals, improving the cellular immunity and reducing blood sugar.
The second purpose of the invention is to provide a processing method of the traditional Chinese medicine prescription for treating diabetes, which comprises the following steps:
(1) Cleaning rape seedlings and mulberry leaves, drying by hot air, mixing the rape seedlings and the mulberry leaves according to the formula proportion, and grinding the rape seedlings and the mulberry leaves to 200-300 meshes for later use;
(2) Pulverizing barley seedling to 300-400 mesh, adding into the mixed powder of rape Miao Sangshe obtained in step (1) according to the proportion of the formula, and stirring uniformly;
(3) Taking ginseng and Chinese yam according to the formula proportion, adding boiling water at 100 ℃ and boiling for 45 minutes, and filtering to obtain a solution A and a solute B;
a) Adding 1/3 of the solution A into the treated rhizoma polygonati powder, and drying again to obtain a solid C;
b) Decocting radix astragali slices with total solute B and formula ratio in 100deg.C boiling water for 30 min, and filtering to obtain solute D and solution E;
c) Mixing 1/4 solution E with all solids C of a), and drying for later use to obtain solids G;
d) Mixing 3/4 solution E with 1/2 solute D, standing for 24 hours, adding the mixed powder of barley seedling rape Miao Sangshe obtained in the step (2), dehydrating again, and drying to obtain solid F;
(4) Boiling the residual 2/3 solution A, the residual 1/2 solute D and all solids G for 6 hours, dehydrating and air-drying, adding the previously mixed solids F, and mixing to obtain mixed powder H;
(5) Mixing the mixed powder H obtained in the step (4) with radix ophiopogonis powder according to the formula ratio, mixing with the cornus officinalis subjected to kernel removal according to the formula ratio, and crushing to 250-300 meshes to obtain the traditional Chinese medicine powder for treating diabetes.
Preferably, the rape seedlings in the step (1) are cabbage type rape seedlings with medium plant size, thicker leaves, wax powder and deep leaf margin, the mulberry leaves are fresh mulberry leaves, and the whole set of vegetable dehydration treatment equipment is adopted for hot air drying.
Preferably, the water content of the barley seedling coarse powder in the step (2) is not higher than 5%, and the barley seedling coarse powder is crushed by a PM100 planetary ball mill.
Preferably, the rhizoma polygonati powder in the step (3) is prepared by the following steps: soaking and cleaning dry rhizoma polygonati according to the proportion of the formula, taking care of cleaning sediment at the nodule, steaming for 4 hours, mixing with yellow wine, wherein the mass ratio of the yellow wine to the rhizoma polygonati is 100:6, stewing at 85 ℃ for 24 hours in a ceramic pot, drying for 6 hours, repeatedly turning over the middle, steaming for 4 hours, drying for 6 hours to form rhizoma polygonati solid, adding gynostemma pentaphylla according to the proportion of the formula, manually twisting the gynostemma pentaphylla until 70% of water is removed, drying together, and adding a pulverizer into a pulverizer to grind to 200-300 meshes.
Preferably, the astragalus tablet in the step (3) is prepared by the following steps: drying radix astragali until 70% -80% of water is removed, cutting off side roots and fibrous roots, stacking for 1-2 days to make them moist, spreading out and airing until it is completely dry, straightening the roots, bundling into small bundles, slicing radix astragali with a slicer to obtain radix astragali slices.
Preferably, the dwarf lilyturf tuber powder in the step (5) is prepared by the following steps: washing radix ophiopogonis in a washing tank, taking out, draining, soaking in 2% concentration saline water for 8-12 hours, taking out, and carrying out sugar boiling: the preparation method comprises the following steps of: radix ophiopogonis mass ratio 5:2 adding water, heating to 80 ℃, and mixing according to the following steps: adding white granulated sugar according to the mass ratio of 20:1, and simultaneously adding the white granulated sugar according to the following weight ratio: adding citric acid into the mixture according to the mass ratio of the citric acid to the mixture of the citric acid and the mixture of the citric acid is 9:1, boiling the mixture for 5 minutes, adding purified water with the mass ratio of ophiopogon root of 1:3 at 30 ℃ for soaking for 3-5 days, and then air-drying and grinding to 200-300 meshes.
Preferably, the drying temperature in the step is 75-95 ℃.
According to the traditional Chinese medicine formula provided by the invention, clinical practice researches of clinical specialists in recent years show that most diabetics can personally use the formula under the guidance of professional doctors, and the combined life style management can obviously and effectively improve various physiological indexes of diabetes, improve the insulin sensitivity of organisms, improve insulin resistance, and finally realize the phenomena of drug reduction and even drug stopping under the condition of independently and stably regulating blood sugar, so that the life quality of the patients can be obviously improved.
Compared with the prior art, the invention has the beneficial effects that:
(1) Enhancing insulin sensitivity of patients, activating and repairing damaged islet cells, promoting insulin secretion, and improving glycolipid metabolism: the barley seedling, the rhizoma polygonati, the astragalus, the Chinese yam and the rape seedling in the formula can effectively improve the blood sugar fluctuation of the T2DM population, reduce blood sugar by influencing the liver glycogen synthesis, the expression of gluconeogenesis related enzymes, improving the intestinal insulin resistance and other modes, promote the liver glycogen synthesis, inhibit gluconeogenesis and improve the islet function;
(2) Replace partial hypoglycemic drugs, reduce accumulated toxic and side effects caused by long-term use of hypoglycemic drugs by T2DM people: according to statistics of experimental results of clinical samples, sulfonylureas and insulin hypoglycemic agents can be reduced as appropriate when the prescription is used, 70% of people can manage stoppable drugs in a personalized nutrition life mode, sulfonylureas drugs mainly cause larger burden to people with liver and kidney insufficiency or excessive dosage through liver metabolism, and the clinical prescription can be considered to replace treatment in order to avoid burden of liver metabolism and kidney excretion;
(3) Improving insulin resistance, reducing apoptosis of islet beta cells: the components of ginseng and the like in the formula can act to increase the expression of skeletal muscle protein kinase B (Akt) and phosphorylating protein kinase B (p-Akt), enhance the glucose transport capacity of glucose transporter 4 (GLUT 4), regulate and control death signal transduction effector 3 (Caspase-3) and inhibit apoptosis cascade reaction;
(4) Inhibiting oxidative stress and inflammatory reaction, and delaying or relieving the development of complications: the gynostemma pentaphylla can effectively reduce the levels of TNF-alpha, IL-1 and IL-6 in serum of a DN model rat, has obvious dose dependence, can reduce the incidence rate of complications such as diabetic foot, diabetic nephropathy and the like by stably regulating and controlling blood sugar, and improves peripheral circulation;
(5) Reducing the economic burden of long-term diabetes family social treatment of patients, reducing the death rate of diabetes and prolonging the health life of diabetes patients: in 2015, the total amount of the economic burden of the diseases of the middle-aged and elderly diabetic patients in China is 5098.85 hundred million yuan, the formula adopts the homology of medicine and food, and the blood sugar can be stably controlled by using the formula according to the individual and reasonable medical advice, so that the diagnosis and treatment cost of the long-term clinical hypoglycemic medicine can be reduced.
Detailed Description
The technical scheme of the invention is further specifically described by the following specific examples.
Example 1
A traditional Chinese medicine formula for treating diabetes is prepared from the following raw materials in parts by weight: 10 parts of barley seedlings, 2 parts of rape seedlings, 2 parts of mulberry leaves, 3 parts of rhizoma polygonati, 5 parts of gynostemma pentaphylla, 3 parts of astragalus membranaceus, 3 parts of Chinese yam, 2 parts of ginseng (ginseng), 1 part of dogwood and 1 part of radix ophiopogonis.
The processing method of the traditional Chinese medicine formula for treating diabetes comprises the following steps:
(1) Cleaning rape seedlings and mulberry leaves, drying by hot air, mixing the rape seedlings and the mulberry leaves according to the formula proportion, and grinding the rape seedlings and the mulberry leaves to 200-300 meshes for later use;
(2) Pulverizing the dried barley seedlings to 300-400 meshes, and then putting the barley seedlings into the mixed powder of the rape Miao Sangshe in the step (1) according to the proportion of the formula and uniformly stirring;
(3) Taking ginseng and Chinese yam according to the formula proportion, adding boiling water at 100 ℃ and boiling for 45 minutes, and filtering to obtain a solution A and a solute B; wherein water is added according to 5 times of the total mass of the ginseng and the Chinese yam;
a) Adding 1/3 of the solution A into the treated rhizoma polygonati powder, and drying again to obtain a solid C;
b) Decocting radix astragali slices with total solute B and formula ratio in 100deg.C boiling water for 30 min, and filtering to obtain solute D and solution E;
c) Mixing 1/4 solution E with all solids C of a), and drying for later use to obtain solids G;
d) Mixing 3/4 solution E with 1/2 solute D, standing for 24 hours, adding the mixed powder of barley seedling rape Miao Sangshe obtained in the step (2), dehydrating again, and drying to obtain solid F;
(4) Boiling the residual 2/3 solution A, the residual 1/2 solute D and all solids G for 6 hours, dehydrating and air-drying, adding the previously mixed solids F, and mixing to obtain mixed powder H;
(5) Removing the pit of the dogwood for standby, mixing the mixed powder H obtained in the step (4) with the ophiopogon root powder according to the formula proportion, mixing with the dogwood according to the formula proportion, and crushing to 250-300 meshes to obtain the traditional Chinese medicine powder for treating diabetes.
Wherein, the rape seedlings in the step (1) are selected from cabbage type rape seedlings with medium plant size, thicker leaves, wax powder and deep leaf margin, the mulberry leaves are selected from fresh mulberry leaves, and the whole set of vegetable dehydration treatment equipment is adopted for hot air drying.
And (3) crushing the barley seedling coarse powder in the step (2) by using a PM100 planetary ball mill, wherein the moisture content of the barley seedling coarse powder is not higher than 5%.
Preferably, the rhizoma polygonati powder in the step (3) is prepared by the following steps: soaking and cleaning dry rhizoma polygonati according to the proportion of the formula, taking care of cleaning sediment at the nodule, steaming for 4 hours, mixing with yellow wine, wherein the mass ratio of the yellow wine to the dry rhizoma polygonati is 100:6, stewing at 85 ℃ for 24 hours in a ceramic pot, drying for 6 hours, repeatedly turning over the middle, steaming for 4 hours, drying for 6 hours to form rhizoma polygonati solid, adding gynostemma pentaphylla according to the proportion of the formula, manually twisting the gynostemma pentaphylla until 70% of water is removed, drying together, and adding a pulverizer into a pulverizer to grind to 200-300 meshes.
Preferably, the astragalus tablet in the step (3) is prepared by the following steps: drying radix astragali until 70% -80% of water is removed, cutting off side roots and fibrous roots, stacking for 1-2 days to make them moist, spreading out and airing until it is completely dry, straightening the roots, bundling into small bundles, slicing radix astragali with a slicer to obtain radix astragali slices.
Preferably, the dwarf lilyturf tuber powder in the step (5) is prepared by the following steps: washing radix ophiopogonis in a washing tank, taking out, draining, soaking in 2% concentration saline water for 8-12 hours, taking out, and carrying out sugar boiling: the preparation method comprises the following steps of: radix ophiopogonis mass ratio 5:2 adding water, heating to 80 ℃, and mixing according to the following steps: adding white granulated sugar according to the mass ratio of 20:1, and simultaneously adding the white granulated sugar according to the following weight ratio: adding citric acid into the mixture according to the mass ratio of the citric acid to the mixture of the citric acid and the mixture of the citric acid is 9:1, boiling the mixture for 5 minutes, adding purified water with the mass ratio of ophiopogon root of 1:3 at 30 ℃ for soaking for 3-5 days, and then air-drying and grinding to 200-300 meshes.
The drying temperature in the steps is 75-95 ℃, and the drying temperature is adjusted according to the property of the drying substance.
Example 2
A traditional Chinese medicine formula for treating diabetes is prepared from the following raw materials in parts by weight: 5 parts of barley seedlings, 1 part of rape seedlings, 1 part of mulberry leaves, 2 parts of rhizoma polygonati, 3 parts of gynostemma pentaphylla, 2 parts of astragalus membranaceus, 2 parts of Chinese yam, 1 part of ginseng (ginseng), 1 part of dogwood and 1 part of radix ophiopogonis. The processing method is the same as in example 1.
Example 3
A traditional Chinese medicine formula for treating diabetes is prepared from the following raw materials in parts by weight: 15 parts of barley seedlings, 3 parts of rape seedlings, 3 parts of mulberry leaves, 6 parts of rhizoma polygonati, 8 parts of gynostemma pentaphylla, 6 parts of astragalus membranaceus, 6 parts of Chinese yam, 3 parts of ginseng (ginseng), 2 parts of dogwood and 2 parts of radix ophiopogonis. The processing method is the same as in example 1.
Test example clinical experiments
The clinical medical team of Hangzhou Qiu He clinic develops clinical experimental researches of diabetes under the guidance of the team of the national institute of health, and the experiment adopts 'cause' to 'fruit', and the experimental effect caused by the experimental results is observed by using the traditional Chinese medicine formula of diabetes as an intervention factor, the experimental source population is all from community personnel in a certain area of Hangzhou, and the reference standard is as follows: age 35-75, two-type diabetes, no serious liver and kidney heart and lung failure, BMI > 18.5, voluntary participation in the experiment researchers, the experiment adopts an operator and subject double-blind mode to carry out random digital table method grouping, 114 persons in a control group, wherein 99 persons in a long-term taking medicine are fed by the control group in a mode of Chinese diabetes diet guide 2017, low GI staple food is selected, whole grains and beans account for 1/3 of the staple food intake, and daily vegetable intake is 300-500 g, and regular meal ordering is carried out. The experimental group is to soak the hypoglycemic traditional Chinese medicine formula of the example 12 bags per day on the basis of the condition of the control group, soak the traditional Chinese medicine formula to 1500-2000 milliliters per day at 100 ℃, collect and count BMI, fasting blood glucose, postprandial 2h blood glucose, glycosylated hemoglobin, medication and physical feeling conditions of each group before and after the experiment as follows:
fasting blood glucose before and after consumption and two hours postprandial blood glucose change comparison (n=222)
Note that: the experimental significance level a=0.05, and in order to improve experimental verification efficiency and avoid the influence of mixed factors such as age, sex and the like, the experiment is synchronously analyzed by adopting a block design. Improvement rate criteria: mean fasting glycemia after no drug intervention-mean fasting glycemia delta > 1.5mmol/L before intervention, and pooled glycosylated hemoglobin tended to change normally.
Conclusion: after counting the data, it can be seen that: the average fasting blood glucose of patients taking the hypoglycemic formula is reduced by 3.12+/-1.78 mmol/L after three months under the guidance of a physician, the postprandial blood glucose of experimental groups is reduced by 4.54+/-1.15 mmol/L, the glycosylated hemoglobin is reduced by 2.49+/-1.41, the average reduction is obviously higher than that of a control group, then, the improvement rate and the stopping rate are in an ascending trend along with the prolonged time of taking the hypoglycemic formula, the average weight reduction condition of the two groups appears, the blood glucose and the like are slightly reduced according to the control group of Chinese diabetes diet guidelines, but the improvement degree is not obvious, and adverse symptoms and reactions such as nausea, vomiting, dizziness, abdominal pain, palpitation and hypodynamia do not appear in each group in the experiment.
Clinical treatment of typical cases
The formulations are personalized under the direction of a professional doctor to use different dosages and methods, and are adjusted by one person and in real time, for example, as follows:
a Chinese medicinal composition for treating diabetes comprises: patient Li xx, male, 47 years old, han nationality, farmer. First diagnosis in 2019, 2 months and 6 days. The patient suffers from type II diabetes for 9 years, has normal urination and good appetite, and has average 7mmol/L and nonalcoholic fatty liver after fasting blood glucose. History of administration: metformin is 2 pieces per day, glimepiride is 1 piece per day, treatment mode: the method comprises the steps of adopting VLCD diet (taking 600-800 kcal energy daily) and CRD (controlling at 1000-1800 kcal/d for men and 1200-1500 kcal/d for women) for 5 consecutive days each month, taking 2 packages of diabetes traditional Chinese medicine formulas daily for the first 5 days, analyzing and personalizing nutrition meal spectrum according to clinical human body ingredients, suspending glimepiride within 5 days, taking diabetes formulas every other day in 25 days, and increasing and decreasing medicines in real time according to the condition of blood sugar recovery dynamic monitoring. The patient successfully reduces the fasting blood glucose to 6.2mmol/L on the 5 th day of treatment, after the fasting blood glucose is stable for 15 days, the metformin is reduced to one piece per day to still keep the fasting blood glucose at 5.1-6.9mmol/L, the complaint is good, the abdominal fat is obviously reduced, the weight is reduced by 4.5kg, the imaging shows that the moderate fatty liver is reduced to the mild fatty liver after the treatment, and the glycosylated hemoglobin is reduced from 8.7 to 6.8 in three months.
A Chinese medicinal composition for treating diabetes comprises: patient wang xx, female, 57 years old, han nationality, farmer. First diagnosis in 2019, 4 months and 8 days. The patient suffers from type II diabetes for 11 years, has normal urination and good appetite, and has average 11mmol/L, BMI of 18.9 and drug history after fasting blood glucose: 15 units of long-acting insulin, glimepiride, 2 times a day, one tablet at a time, treatment mode: the preparation method comprises the steps of administering 2 bags of hypoglycemic prescription daily for 5 days, brewing with boiled water, repeatedly brewing on the same day until the taste is light, the insulin is halved, and suspending glimepiride, and then administering one bag of hypoglycemic prescription daily for 25 days, and combining with low GI diet management. After treatment, the patient pauses the long-acting insulin, the glimepiride is reduced from one to half, the fasting blood glucose is still stably maintained at 6.1-7.8mmol/L, skeletal muscle is increased by 1.5Kg, weight is increased by 3Kg, and leg circulation is improved.
A Chinese medicinal composition for treating diabetes comprises the following three embodiments: the patient is Xuexx, female, 43 years old, han nationality, resident. First diagnosis in 2019, 5 months and 18 days. The patient suffers from type II diabetes for 3 years, normal urination and defecation, good appetite, BMI20, type I diabetes, glycosylated hemoglobin 9.2, average blood sugar of 17 after two hours after meal, and medicine history: medium-acting insulin 24 units per day, metformin 2 days, acarbose 2 days, treatment regimen: the blood sugar reducing prescription is taken 2 bags a day before three days, the medium-effect insulin can be halved for use, adverse living habits such as drinking and the like are avoided, the blood sugar reducing prescription is taken one bag a day after 15 days, the blood sugar reducing prescription is taken one bag a day at 15 day intervals for out-patient review, the blood sugar reducing prescription is brewed by boiled water, and the brewing time is more than 1500 milliliters each day. The insulin sensitivity of the patient is enhanced after treatment, the medium-effect insulin is stopped for 24 units, the average fasting blood glucose of the patient per day is maintained at 6.5-7.2 under the condition of the original dosage of oral hypoglycemic agent, the average blood glucose of the patient after two hours after meal is 12.1, and the glycosylated hemoglobin is reduced to 7.2 after three months.
Comparative example
The excellent effect of the traditional Chinese medicine composition compared with other blood sugar reducing modes is shown in the table below. As can be seen from the following table, the traditional Chinese medicine formula for treating diabetes has obvious blood glucose reducing effect because of the property of homology of medicine and food, and is very suitable for clinical selection of diabetics.
The above-described embodiments are only preferred embodiments of the present invention, and are not intended to limit the invention in any way, but other variations and modifications are possible without exceeding the technical solutions described in the claims.
Claims (7)
1. The traditional Chinese medicine formula for treating diabetes is characterized by being prepared from the following raw materials in parts by weight: 5-15 parts of barley seedlings, 1-3 parts of rape seedlings, 1-3 parts of mulberry leaves, 2-6 parts of rhizoma polygonati, 3-8 parts of gynostemma pentaphylla, 2-6 parts of astragalus membranaceus, 2-6 parts of Chinese yam, 1-3 parts of ginseng, 1-2 parts of dogwood and 1-2 parts of radix ophiopogonis; the processing method of the traditional Chinese medicine formula comprises the following steps:
(1) Cleaning rape seedlings and mulberry leaves, drying by hot air, mixing the rape seedlings and the mulberry leaves according to the formula proportion, and grinding the rape seedlings and the mulberry leaves to 200-300 meshes for later use;
(2) Pulverizing barley seedling to 300-400 mesh, adding into the mixed powder of rape Miao Sangshe obtained in step (1) according to the proportion of the formula, and stirring uniformly;
(3) Taking ginseng and Chinese yam according to the formula proportion, adding boiling water at 100 ℃ and boiling for 45 minutes, and filtering to obtain a solution A and a solute B;
a) Adding 1/3 of the solution A into the treated rhizoma polygonati powder, and drying again to obtain a solid C;
b) Decocting radix astragali slices with total solute B and formula ratio in 100deg.C boiling water for 30 min, and filtering to obtain solute D and solution E;
c) Mixing 1/4 solution E with all solids C of a), and drying for later use to obtain solids G;
d) Mixing 3/4 solution E with 1/2 solute D, standing for 24 hours, adding the mixed powder of barley seedling rape Miao Sangshe obtained in the step (2), dehydrating again, and drying to obtain solid F;
(4) Boiling the residual 2/3 solution A, the residual 1/2 solute D and all solids G for 6 hours, dehydrating and air-drying, adding the previously mixed solids F, and mixing to obtain mixed powder H;
(5) Mixing the mixed powder H obtained in the step (4) with radix ophiopogonis powder according to a formula ratio, mixing with the cornus officinalis subjected to kernel removal according to a formula ratio, and crushing to 250-300 meshes to obtain traditional Chinese medicine powder for treating diabetes;
the rhizoma polygonati powder in the step (3) is prepared through the following steps: soaking and cleaning dry rhizoma polygonati according to the proportion of the formula, taking care of cleaning sediment at the nodule, steaming for 4 hours, mixing with yellow wine, wherein the mass ratio of the yellow wine to the rhizoma polygonati is 100:6, stewing at 85 ℃ for 24 hours in a ceramic pot, drying for 6 hours, repeatedly turning over the middle, steaming for 4 hours, drying for 6 hours to form rhizoma polygonati solid, adding gynostemma pentaphylla according to the proportion of the formula, manually twisting the gynostemma pentaphylla until 70% of water is removed, drying together, and adding a pulverizer into a pulverizer to grind to 200-300 meshes.
2. The traditional Chinese medicine formula for treating diabetes according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 10 parts of barley seedlings, 2 parts of rape seedlings, 2 parts of mulberry leaves, 3 parts of rhizoma polygonati, 5 parts of gynostemma pentaphylla, 3 parts of astragalus membranaceus, 3 parts of Chinese yam, 2 parts of ginseng, 1 part of dogwood and 1 part of radix ophiopogonis.
3.A method for processing a traditional Chinese medicine formula for treating diabetes according to any one of claims 1-2, which is characterized by comprising the following steps:
(1) Cleaning rape seedlings and mulberry leaves, drying by hot air, mixing the rape seedlings and the mulberry leaves according to the formula proportion, and grinding the rape seedlings and the mulberry leaves to 200-300 meshes for later use;
(2) Pulverizing barley seedling to 300-400 mesh, adding into the mixed powder of rape Miao Sangshe obtained in step (1) according to the proportion of the formula, and stirring uniformly;
(3) Taking ginseng and Chinese yam according to the formula proportion, adding boiling water at 100 ℃ and boiling for 45 minutes, and filtering to obtain a solution A and a solute B;
a) Adding 1/3 of the solution A into the treated rhizoma polygonati powder, and drying again to obtain a solid C;
b) Decocting radix astragali slices with total solute B and formula ratio in 100deg.C boiling water for 30 min, and filtering to obtain solute D and solution E;
c) Mixing 1/4 solution E with all solids C of a), and drying for later use to obtain solids G;
d) Mixing 3/4 solution E with 1/2 solute D, standing for 24 hours, adding the mixed powder of barley seedling rape Miao Sangshe obtained in the step (2), dehydrating again, and drying to obtain solid F;
(4) Boiling the residual 2/3 solution A, the residual 1/2 solute D and all solids G for 6 hours, dehydrating and air-drying, adding the previously mixed solids F, and mixing to obtain mixed powder H;
(5) Mixing the mixed powder H obtained in the step (4) with radix ophiopogonis powder according to a formula ratio, mixing with the cornus officinalis subjected to kernel removal according to a formula ratio, and crushing to 250-300 meshes to obtain traditional Chinese medicine powder for treating diabetes;
the rhizoma polygonati powder in the step (3) is prepared through the following steps: soaking and cleaning dry rhizoma polygonati according to the proportion of the formula, taking care of cleaning sediment at the nodule, steaming for 4 hours, mixing with yellow wine, wherein the mass ratio of the yellow wine to the rhizoma polygonati is 100:6, stewing at 85 ℃ for 24 hours in a ceramic pot, drying for 6 hours, repeatedly turning over the middle, steaming for 4 hours, drying for 6 hours to form rhizoma polygonati solid, adding gynostemma pentaphylla according to the proportion of the formula, manually twisting the gynostemma pentaphylla until 70% of water is removed, drying together, and adding a pulverizer into a pulverizer to grind to 200-300 meshes.
4. The method for preparing a Chinese medicinal composition for treating diabetes according to claim 3, wherein the rape seedlings in the step (1) are cabbage type rape seedlings with medium plant size, thicker leaves, wax powder and deep cut edges, the mulberry leaves are fresh mulberry leaves, and the whole set of vegetable dehydration treatment equipment is adopted for hot air drying.
5. The method of claim 3, wherein the barley seedling meal in step (2) has a moisture content of not more than 5% and is crushed by a PM100 planetary ball mill.
6. The method for processing a traditional Chinese medicine formula for treating diabetes according to claim 3, wherein the astragalus tablet in the step (3) is prepared by the following steps: drying radix astragali until 70% -80% of water is removed, cutting off side roots and fibrous roots, stacking for 1-2 days to make them moist, spreading out and airing until it is completely dry, straightening the roots, bundling into small bundles, slicing radix astragali with a slicer to obtain radix astragali slices.
7. The method for preparing a traditional Chinese medicine composition for treating diabetes according to claim 3, wherein the ophiopogon root powder in the step (5) is prepared by the following steps: washing radix ophiopogonis in a washing tank, taking out, draining, soaking in 2% concentration saline water for 8-12 hours, taking out, and carrying out sugar boiling: the preparation method comprises the following steps of: radix ophiopogonis mass ratio 5:2 adding water, heating to 80 ℃, and mixing according to the following steps: adding white granulated sugar according to the mass ratio of 20:1, and simultaneously adding the white granulated sugar according to the following weight ratio: adding citric acid into the mixture according to the mass ratio of the citric acid to the mixture of the citric acid and the mixture of the citric acid is 9:1, boiling the mixture for 5 minutes, adding purified water with the mass ratio of ophiopogon root of 1:3 at the temperature of 30 ℃ for soaking for 3-5 days, and then air-drying and grinding to 200-300 meshes.
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