CN104491181B - A kind of Chinese medicine composition of hair growth and its preparation method and application - Google Patents
A kind of Chinese medicine composition of hair growth and its preparation method and application Download PDFInfo
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- CN104491181B CN104491181B CN201510003071.1A CN201510003071A CN104491181B CN 104491181 B CN104491181 B CN 104491181B CN 201510003071 A CN201510003071 A CN 201510003071A CN 104491181 B CN104491181 B CN 104491181B
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Abstract
The invention discloses Chinese medicine compositions of a kind of hair growth and its preparation method and application, belong to the field of Chinese medicines.The traditional chinese medicine composition of the invention is made of the bulk pharmaceutical chemicals of following parts by weight: 50-100 parts of Radix Angelicae Sinensis, 30-80 parts of mulberry fruit, 10-60 parts of mulberry leaf, 20-70 parts of fructus lycii, 45-95 parts of the fruit of glossy privet, 15-65 parts of glutinous rehmannia, 40-90 parts of Radix Astragali, 70-120 parts of the fleece-flower root (system), 25-75 parts of cacumen biotae, 45-95 parts of eclipta, 20-70 parts of Rhizoma Chuanxiong, 60-110 parts of Semen sesami nigrum, 35-85 parts of Semen Cuscutae, 55-105 parts of Rehmannia glutinosa, 40-90 parts of Caulis Spatholobi.Clinical observation experiment the result shows that, the traditional chinese medicine composition of the invention has significant curative effect for alopecia areata, whole alopecia, general alopecia and other type baldnesses, and has no any adverse reaction, illustrates that the traditional chinese medicine composition of the invention is a kind of hair growth safely and effectively composition.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, in particular to a kind of Chinese medicine composition of hair growth and preparation method thereof
And application, belong to the field of Chinese medicines.
Background technique
De- (bald) hair is whole world common disease, especially more prominent in developing country.Data show that China 20~50
Year, people's alopecia illness rate was up to 20~30%, and de- (bald) the hair patient of China is also thought in most conservative estimation, and there are about more than 100,000,000 people, dive
In minimum four million people in consumption market.It is the open epoch now, closely, personal image is critically important for person to person's contact, so
People start to pay attention to de- (bald) question topic.Therefore, the product market demand capacity of de- (bald) hair of exploitation treatment is larger.Alopecia is to face
The common trichonosis of bed generates large effect to spirit, the psychology of people though not belonging to serious disease.With living standard
Raising, requirement of the people to cosmetology be increasingly urgent to, and modern medicine and traditional medicine are also increasingly paid attention to grinding alopecia
Study carefully.
Alopecia includes alopecia areata, alopecia seborrheica, the property alopecia of male sex hormone source, psychogenic alopecia etc., belongs to traditional Chinese medicine " oil
Wind ", " alopecia seborrheica " scope.Hair loss patient, which is frequently due to certain factors, causes hair to enter hair growth too early by growth period
Resting stage, hair follicle and ball top atrophy, thin hair is become from terminal hair and cause (Springer K, Brown M,
Stulberg DL.Common hair loss disorders[J].Am Fam Physician,2003,68(1):93-
102).Alopecia areata is more common in person between twenty and fifty, and men and women's disease incidence is essentially identical, often occurs suddenly, more no conscious symptons, is in the non-scar of limitation
Trace, inflammatory round or ellipse patch shape alopecia, not of uniform size, boundary is obvious.Patients with alopecia areata early stage visible growth
The hair development of phase is bad, perifollicolar CD4 +T cell infiltration.Advanced stage visible hair follicle atrophy, hair and papilla become smaller, newly
The non-full-shape of setation, the visible vasculitis of intradermal and periangiitis, blood vessel reticular density are reduced.In recent years modern medicine grinds it
Study carefully more, result of study shows that alopecia areata is the auto-immune related disease that a kind of T cell mediates, and clinical manifestation is benign, non-
Cicatricial baldness, more no conscious symptons can betide any coat position of whole body, and serious person can be to whole alopecia and general alopecia.Entirely
Bald common sense: there are about 5%~10% case, its baldness gradually can be carried out or be rapidly developed in alopecia areata, in several days or some months
Hair all falls off into whole alopecia, and What is more can be involved eyebrow, beard, armpit hair, pubes etc. for the symptom of whole alopecia, and only a few is serious
Person whole body fine hair on birds or animals Mao Yike takes off light, referred to herein as general alopecia.Chinese medicine thinks that alopecia areata betides kidney deficiency and liver, essence and blood loss and wind and contains blood-head more
Etc. correlations.Modern medicine believes that, this disease be autoimmune disease, with inherent cause, mental element, immune function, endocrine,
Microcirculation and microelement etc. are abnormal related.
Alopecia areata category traditional Chinese medicine " alopecia areata " scope, Chinese medicine think " hair is the sign of blood condition ", wind formation from blood deficiency, blood hot air wind producing or liver deficiency of the kidney
Damage is alopecia areata because of place, and successive dynasties medicine discusses alopecia areata etiology and pathogenesis in terms of these." surgery is authentic " records " oil
Wind is that the deficiency of blood cannot support skin with gas honor, therefore hair root is empty, fall off in flakes ... ... this all blood-head take advantage of a weak point in opponent's defence attack note and right "." surgery
Great achievement " it says: " then hair fall in flakes, skin Lightening, formicant itching person are alopecia areata, are taken advantage of a weak point in opponent's defence by wind-heat and attack note, and blood flourish cannot support
It is caused "., alopecia areata is referred to as " pore wind attacks blood of causing injury " in Golden Mirror of Medicine, and the Sui Dynasty " General Treatise on the Cause and Symptoms of Diseases " is said: " people has ailment said due to cold or exposure in head,
Have at void partially, then falling out, muscle is withered, or refers to that greatly, hair is not given birth to, and is not also itched greatly or such as such as money, therefore licks head for ghost ", furthermore it is somebody's turn to do
Also indicated that in book " foot-shaoyang gallbladder through, honor in palpus, kidney meridian is respected work, Hua Fa.The arteries and veins that punching is appointed, for 12 warps
Sea, the sea of blood of meaning, lip on other network.Honor is in beard and hair if blood is contained, therefore beard and hair is beautiful；If vim and vigour are weak, exhausted through feeble pulse, it cannot
Rong Run, therefore beard and hair is bald falls ".
In addition, the generation of alopecia areata is also related with emotional factors.Theory of traditional Chinese medical science thinks that happiness is then sad, anger then then hurt by the impariment of the liver, think of
Spleen, compassion then hurt lung, are probably then impairment of the kidney, and disease caused by feelings will is hurt is more with the heart, liver, dirty spleen three.The heart rises in the feelings will variation of human body
Leading role, it is grieved, qi and blood uplink cannot be pushed away and nourish hair, hair is easily made to dry up, fall off.Melancholy,anxiety and spleen, taste are raw for qi and blood
The source of change.Depressed rage impairing the liver, blood stored in the liver and main catharsis, stagnation of liver qi then lose in catharsis, and qi and blood cannot continue flourish feeding hair, so that de-
It falls.Furthermore sad lung, terror impariring kidney equally will affect the growth and development of hair, cause alopecia.
Alopecia areata is the common difficult and complicated cases of dermatology, has become the research emphasis of dermatology in recent years, and achieve compared with
Quantum jump.Each doctor is aligned to the understanding day of this disease, it is believed that traditional Chinese medicine has its advantageous advantage in terms for the treatment of this disease.
Diagnosis and treatment is not only flexible and changeable, meets the demand of individuation, safely and effectively, is suitable for taking for a long time, while can be to avoid doctor trained in Western medicine
The shortcomings that treatment.Chinese medicine Nei Zhi method has given full play to the characteristic of Chinese medicine organic conception and diagnosis and treatment, adjusts machine on the whole
Body function is to effect a permanent cure.Chinese medicine compound prescription has many advantages, such as that curative for effect, toxic side effect is small, under instruction of Chinese Medicine theory, goes out from entirety
Hair, adjusts the equilibrium between yin and yang of body, treating both manifestation and root cause of disease has obtained preferable clinical efficacy.Chinese medicine compound prescription is screened, it is disclosed
Mechanism of action, develops safer, effective cmm of simple prescription and compound has become main research direction.This product has nourishing
Liver kidney, QI invigorating support honor, and the function of active hair tonic is used for baldness.Inventive formulation can be nourishing liver and kidney, by whole body qi and blood liver
The maintenance of kidney, fundamentally treats it, reaches therapeutic purposes, curative for effect.
Summary of the invention
The first purpose of this invention is to provide a kind of Chinese medicine composition of hair growth.
Second object of the present invention is to provide a kind of method of tablet for preparing above-mentioned Chinese medicine composition.
Third object of the present invention is that providing above-mentioned Chinese medicine composition is preparing the purposes in hair growth drug.
Above-mentioned purpose of the present invention is achieved by the following technical solution:
A kind of Chinese medicine composition of hair growth, is made of the bulk pharmaceutical chemicals of following parts by weight: 50-100 parts of Radix Angelicae Sinensis, mulberry fruit
30-80 parts, 10-60 parts of mulberry leaf, 20-70 parts of fructus lycii, 45-95 parts of the fruit of glossy privet, 15-65 parts of glutinous rehmannia, 40-90 parts of Radix Astragali, He Shou
70-120 parts of black (system), 25-75 parts of cacumen biotae, 45-95 parts of eclipta, 20-70 parts of Rhizoma Chuanxiong, 60-110 parts of Semen sesami nigrum, Semen Cuscutae
35-85 parts, 55-105 parts of Rehmannia glutinosa, 40-90 parts of Caulis Spatholobi.
Preferably, the parts by weight of each bulk pharmaceutical chemicals are as follows: 75 parts of Radix Angelicae Sinensis, 50 parts of mulberry fruit, 35 parts of mulberry leaf, 50 parts of fructus lycii, glossy privet
Sub 70 parts, 40 parts of glutinous rehmannia, 60 parts of Radix Astragali, 90 parts of the fleece-flower root (system), 50 parts of cacumen biotae, 70 parts of eclipta, 45 parts of Rhizoma Chuanxiong, Semen sesami nigrum
80 parts, 60 parts of Semen Cuscutae, 80 parts of Rehmannia glutinosa, 65 parts of Caulis Spatholobi.
Inventor is summarized by the clinical research of many years in conjunction with the dialectical principle combined with the differentiation of disease to nourish
Liver kidney, QI invigorating support honor, and active hair tonic is the Chinese medicine composition of the main rules for the treatment of, try out in clinic, alopecia is achieved and is more managed
The therapeutic effect thought.
In Chinese medicine composition of the invention: Radix Angelicae Sinensis: sweet, acrid, warm；Enter the heart, liver, the spleen channel, there is benefiting blood and regulating blood circulation, menstruction regulating and pain relieving
The effect of.
Mulberry fruit: acid sweet in flavor, cold nature enter the heart, liver and kidney channel, are strengthening by means of tonics, the good fruit of nourishing heart intelligence development.With enriching yin of enriching blood,
It promotes the production of body fluid to quench thirst, ease constipation is dry and other effects, cure mainly deficiency of YIN-blood and having a dizzy spell for causing, tinnitus palpitaition, irritated insomnia, soreness and weakness of waist and knees,
Poliosis, dry of quenching one's thirst, the diseases such as dry and hard excrement.
Mulberry leaf: bitter, it is sweet, it is cold in nature；It is distributed in lung channel, Liver Channel；With clearing liver nourishing the liver, dispelling wind and heat from the body, clearing lung-heat, improving eyesight and other effects,
Cure mainly anemopyretic cold；Wind-warm syndrome is from the beginning of, fever and headache, perspiration and aversion to wind, pectoralgia of coughing；Or dryness of the lung dry cough without phlegm；Dry throat and mouth；Wind-heat
And it is disturbed on liver-yang；The diseases such as red eye, swell pain.
Fructus lycii: it is sweet, flat, enter liver and kidney channel, there is the effect of nourshing kidney, moistening lung, tonifying liver, improving eyesight.
The fruit of glossy privet: for the dry mature fruit of Oleaceae plants glossy privet Ligustrum lucidum Ait..Winter fruit
It is harvested when mature, removes branches and leaves, it is dry after slightly steaming or setting in boiling water and slightly to scald；Or convection drying.Sweet, bitter, cold.Return liver and kidney channel.
Function with the major functions: nourishing liver and kidney, improving eyesight black hair.For dizziness and tinnitus, soreness and weakness of waist and knees, poliosis, mesh is secretly unknown.
Glutinous rehmannia, Rehmannia glutinosa derive from the dry root of scrophulariaceae rehmannia glutinosa plant, are the different processed goods of same drug.Glutinous rehmannia
For the dry product of fresh goods, Rehmannia glutinosa steams product for glutinous rehmannia.The two energy Yin-nourishing and body fluid promoting, controls all diseases of Yin and fluid deficiency.Glutinous rehmannia is longer than
Cool blood, Rehmannia glutinosa, which is longer than, enriches blood.Glutinous rehmannia bitter-cold herbs expelling heat, sweet cold matter moisten yin-nourishing, and for refrigerant moist product, it is cool to be good at nourishing Yin and clearing heat
Blood.Effect clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, ease constipation.Rehmannia glutinosa tepor matter profit sweet in flavor, enters liver kidney two warp, is not only apt to enrich blood enriching yin, but also energy
Enriching essence and nourishing marrow cures mainly the disease of all deficiency of blood yin deficiency defective ejaculations.It can also control that the soreness of waist of blood and essence asthenia, foot is soft, feel dizzy, deaf ear
The diseases such as ring, poliosis.
Radix Astragali: for leguminous mongolian scutellaria Astragalus membranaceus (Fisch.)
Bge.var.mongholicus (Bge.) Hsiao or Astragalus membranacus tragalus membranaceus (Fisch.) Bge.'s is dry
Dry.Sweet, warm.Return lung, the spleen channel.With invigorating qi, consolidating exterior, promoting urination and detoxification, apocenosis, the functions such as expelling pus and promoting granulation.
The fleece-flower root: for the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb..Slightly warm in nature,
It is sweet in flavor, puckery.Return liver and kidney channel.With help essence and blood, nourishing the liver is calmed the nerves, strengthening the bones and muscles, the function for the black palpus that reinforces the kidney.
Cacumen biotae: for the drying branch tip and leaf of cupressaceae plant arbor-vitae Platycladus orientalis (L.) Franco.
It is bitter, puckery, it trembles with fear.Return lung, liver, the spleen channel.Function with the major functions: cooling blood and hemostasis, growing and blacking hair.For hematemesis and epistaxis, hemoptysis, hematochezia collapses
Leak down blood, blood-head alopecia, poliosis.
Eclipta: nature and flavor are sweet, sour, cold；Return kidney, Liver Channel.Major function:: nourishing liver and kidney, cooling blood and hemostasis.For tooth pine
It is dynamic, poliosis, dizziness and tinnitus, soreness and weakness of waist and knees, YinXuXueRe, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux, metrostaxis, traumatic hemorrhage.
Rhizoma Chuanxiong: acrid in flavour and warm in nature for the dry rhizome of umbelliferae Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Return
Liver, gallbladder, pericardium channel.There are blood-activating and qi-promoting, the function of wind-expelling pain-stopping.
Semen sesami nigrum: nature and flavor be it is sweet, flat, return liver, kidney, large intestine channel.It is nourishing liver and kidney, benefiting essence-blood, profit that its major function, which cures mainly,
Intestinal dryness.For dizzy, Hiccough and deaf, poliosis, post disease alopecia, the diseases such as dry constipation of intestines.
Channel tropism: smell is pungent, and sweet and neutral is nontoxic.Function with the major functions: tonifying kidney and benefiting sperm, nourishes the liver to improve visual acuity.Waist suitable for kidney deficiency and liver
Knee muscles and bones is ached, and legs and feet are weak and feeble, impotence and seminal emission, crazy talk, frequent urination, dripping urination, dizzy, blurring of vision, ear
The diseases such as ring deafness and women's leukorrhagia, habitual abortion.
Caulis Spatholobi: the drying rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn, meridian distribution of property and flavor:
Bitter, sweet, warm.Return liver and kidney channel.Major function: enriching blood, invigorate blood circulation, dredging collateral.For irregular menstruation, blood deficiency chlorosis, paralysis and numbness, wind
Arthritis with fixed pain caused by dampness pain.
" Plain Questions 〃 the five internal organs generate a piece " cloud: " the tissue connected with the kidney being bone, honor hair ", " Plain Questions 〃 ancient times innocence opinion " cloud: " kidney qi
Decline, alopecia tooth is withered ", therefore treating should be based on kidney tonifying, " surgery orthodox school 〃 alopecia areata " side: " alopecia areata is that the deficiency of blood cannot support flesh with gas honor
Skin, therefore hair root is empty, falls off in flakes ", " the secret record of Feng Shi embroidered purse " side: " after hair is blood, fall off suddenly, scalp is itched more, and man is simultaneously
The person of falling, is blood hot air wind producing, wind wood shake as ", therefore wind should be searched with the promoting flow of qi and blood circulation as assistant, number medicine of the present invention shares, by right
Nourishing liver and kidney, the promoting flow of qi and blood circulation is played in the maintenance of whole body qi and blood liver kidney altogether, and bald function is controlled in hair tonic, obtains good therapeutic effect.
Bulk pharmaceutical chemicals used in the present invention can be commercially available from common pharmacy, and specification meets national medicine mark
It is quasi-.
Further, the present invention provides a kind of methods of tablet for preparing above-mentioned Chinese medicine composition.The following steps are included:
(1) each bulk pharmaceutical chemicals: 50-100 parts of Radix Angelicae Sinensis, 30-80 parts of mulberry fruit, 10-60 parts of mulberry leaf, fructus lycii are weighed by following weight parts
20-70 parts sub-, 45-95 parts of the fruit of glossy privet, 15-65 parts of glutinous rehmannia, 40-90 parts of Radix Astragali, 70-120 parts of the fleece-flower root (system), cacumen biotae 25-
75 parts, 45-95 parts of eclipta, 20-70 parts of Rhizoma Chuanxiong, 60-110 parts of Semen sesami nigrum, 35-85 parts of Semen Cuscutae, 55-105 parts of Rehmannia glutinosa, chicken
40-90 parts of blood rattan；
(2) it crushes
The fleece-flower root (system) of Radix Angelicae Sinensis, Rhizoma Chuanxiong, cacumen biotae and 1/3 parts by weight is placed in co-grinding in pulverizer, is sieved, i.e.,
Obtain crude drug powder；
(3) it extracts
By mulberry fruit, mulberry leaf, fructus lycii, the fruit of glossy privet, glutinous rehmannia, Radix Astragali, eclipta, Semen sesami nigrum, Semen Cuscutae, Rehmannia glutinosa, chicken blood
The fleece-flower root (system) of rattan and remaining 2/3 parts by weight is set in extractor, is added water to cook, decoction liquor filtering, filtrate concentration to get
Medicinal extract；
(4) granulation, whole grain
After mixing by starch and crude drug powder, with medicinal extract spraying granulation, the particle after drying is subjected to whole grain；
(5) mixing, tabletting
Particle after whole grain is mixed, mixed whole grain is subjected to tabletting, every slice weight 0.3g later；
(6) it is coated, packs
Substrate is coated according to the sequence of sub-coat, sugarcoating layer, coloured sugarcoating layer, polishing.Sugar coated tablet is subjected to aluminium
Modeling packaging.
In the present invention, it is preferred that sieving described in step (2) was 80 meshes.
In the present invention, it is preferred that step (3) is by mulberry fruit, mulberry leaf, fructus lycii, the fruit of glossy privet, glutinous rehmannia, Radix Astragali, eclipta, black
Sesame, Semen Cuscutae, Rehmannia glutinosa, Caulis Spatholobi and remaining 2/3 parts by weight the fleece-flower root (system) set in extractor, add 10-12 times
Measure water decoct twice, every time decoct 2-3 hour, merge decoction liquor, decoction liquor filter, filtrate be concentrated into relative density 1.00~
1.30 to get medicinal extract.
In the present invention, it is preferred that whole grain described in step (4) must not exceed for the particle that can be sieved by No. two after whole grain
20%, and the fine powder that No. six sieves can not crossed.
In the present invention, it is preferred that be mixed into mixing 20-40 minutes described in step (5).
The present invention consists of traditional chinese medicines, and part medicinal material is used as medicine for fine powder, remaining medicinal material need to decoct for several times, until being concentrated to suitably
Medicinal extract, sugar coated tablet is prepared after mixing with fine powder, since part medicinal material contains volatile component, design experiment control in preparation process
The parameters such as Extracting temperature, time, amount of water receive cream rate to improve.The quality standard of product is improved simultaneously, makes product quality can
It leans on, controllably.
Further, the present invention also provides above-mentioned Chinese medicine compositions to prepare the purposes in hair growth drug.
In the present invention, it is preferred that the alopecia includes alopecia areata, whole alopecia, general alopecia, traumatic alopecia or Cicatricial baldness.
The usage and dosage of the traditional chinese medicine composition of the invention: the dosage of the traditional chinese medicine composition of the invention depends on the serious journey of the state of an illness
The result of degree and drug sensitive detection.As guidance: tablet: light-duty patient per 6 takes orally 3 times a day, and moderate patient per 7,
It takes orally 3 times a day, 8 tablets once by the obvious person of scalp inflammation, takes orally 3 times a day, and two weeks as a treatment course.
Specific embodiment
Below by experiment and the present invention will be further described in conjunction with the embodiments, it should be understood that these embodiments
It is only used for the purpose of illustration, is never limited in protection scope of the present invention.
Embodiment 1
Weigh each bulk pharmaceutical chemicals by following weight: Radix Angelicae Sinensis 50g, mulberry fruit 30g, mulberry leaf 10g, fructus lycii 20g, fruit of glossy privet 45g,
Yellow 15g, Radix Astragali 40g, the fleece-flower root (system) 70g, cacumen biotae 25g, eclipta 45g, Rhizoma Chuanxiong 20g, Semen sesami nigrum 60g, Semen Cuscutae 35g,
Rehmannia glutinosa 55g, Caulis Spatholobi 40g；The fleece-flower root (system) of Radix Angelicae Sinensis, Rhizoma Chuanxiong, cacumen biotae and 1/3 parts by weight is placed in pulverizer and is mixed
It crushes, crosses 80 meshes to get crude drug powder；By mulberry fruit, mulberry leaf, fructus lycii, the fruit of glossy privet, glutinous rehmannia, Radix Astragali, eclipta, Semen sesami nigrum, Tu
Silk, Rehmannia glutinosa, Caulis Spatholobi and remaining 2/3 parts by weight the fleece-flower root (system) set in extractor, add 10 times of amount water decoctions two
It is secondary, it decocts 2 hours every time, merges decoction liquor, decoction liquor filtering, filtrate is concentrated into relative density 1.00~1.30 to get medicinal extract；
After mixing by starch and crude drug powder, with medicinal extract spraying granulation, the particle after drying is subjected to whole grain, two can be passed through after whole grain
The particle of number sieve must not exceed 20%, and without can No. six fine powders sieved of mistake；Particle after whole grain is mixed, incorporation time
It is 20 minutes, mixed whole grain is subjected to tabletting, every slice weight 0.3g later；By substrate according to sub-coat, sugarcoating layer, have sugar colour
Clothing layer, polishing sequence be coated, sugar coated tablet is carried out aluminum-plastic packaged.
Embodiment 2
Each bulk pharmaceutical chemicals: Radix Angelicae Sinensis 100g, mulberry fruit 80g, mulberry leaf 60g, fructus lycii 70g, the fruit of glossy privet are weighed by following weight parts
95g, glutinous rehmannia 65g, Radix Astragali 90g, the fleece-flower root (system) 120g, cacumen biotae 75g, eclipta 95g, Rhizoma Chuanxiong 70g, Semen sesami nigrum 110g, Tu
The sub- 85g of silk, Rehmannia glutinosa 105g, Caulis Spatholobi 90g；The fleece-flower root (system) of Radix Angelicae Sinensis, Rhizoma Chuanxiong, cacumen biotae and 1/3 parts by weight is placed in powder
Co-grinding in broken machine crosses 80 meshes to get crude drug powder；By mulberry fruit, mulberry leaf, fructus lycii, the fruit of glossy privet, glutinous rehmannia, Radix Astragali, ink drought
Lotus, Semen sesami nigrum, Semen Cuscutae, Rehmannia glutinosa, Caulis Spatholobi and remaining 2/3 parts by weight the fleece-flower root (system) set in extractor, add 12
Times amount water decoct twice, every time decoct 3 hours, merge decoction liquor, decoction liquor filtering, filtrate be concentrated into relative density 1.00~
1.30 to get medicinal extract；After mixing by starch and crude drug powder, with medicinal extract spraying granulation, the particle after drying is subjected to whole grain,
The particle that can be sieved by No. two after whole grain must not exceed 20%, and the fine powder without that can cross No. six sieves；By the particle after whole grain into
Row mixing, incorporation time are 40 minutes, and mixed whole grain is carried out tabletting, every slice weight 0.3g later；By substrate according to powder clothing
Layer, sugarcoating layer, coloured sugarcoating layer, polishing sequence be coated, sugar coated tablet is carried out aluminum-plastic packaged.
Embodiment 3
Weigh each bulk pharmaceutical chemicals by following weight parts: Radix Angelicae Sinensis 75g, mulberry fruit 50g, mulberry leaf 35g, fructus lycii 50g, fruit of glossy privet 70g,
Glutinous rehmannia 40g, Radix Astragali 60g, the fleece-flower root (system) 90g, cacumen biotae 50g, eclipta 70g, Rhizoma Chuanxiong 45g, Semen sesami nigrum 80g, Semen Cuscutae
60g, Rehmannia glutinosa 80g, Caulis Spatholobi 65g；The fleece-flower root (system) of Radix Angelicae Sinensis, Rhizoma Chuanxiong, cacumen biotae and 1/3 parts by weight is placed in pulverizer
Co-grinding crosses 80 meshes to get crude drug powder；By mulberry fruit, mulberry leaf, fructus lycii, the fruit of glossy privet, glutinous rehmannia, Radix Astragali, eclipta, black sesame
Fiber crops, Semen Cuscutae, Rehmannia glutinosa, Caulis Spatholobi and remaining 2/3 parts by weight the fleece-flower root (system) set in extractor, add 11 times of amount decoctings
It boils twice, decocts 2.5 hours every time, merge decoction liquor, decoction liquor filtering, filtrate is concentrated into relative density 1.00~1.30, i.e.,
Obtain medicinal extract；After mixing by starch and crude drug powder, with medicinal extract spraying granulation, the particle after drying is subjected to whole grain, after whole grain
The particle that can be sieved by No. two must not exceed 20%, and the fine powder without that can cross No. six sieves；Particle after whole grain is mixed,
Incorporation time is 30 minutes, and mixed whole grain is carried out tabletting, every slice weight 0.3g later；By substrate according to sub-coat, sugar-coat
Layer, coloured sugarcoating layer, polishing sequence be coated, sugar coated tablet is carried out aluminum-plastic packaged.
The report of test example the traditional chinese medicine composition of the invention hair growth clinical summary
1. test method:
Detailed history-taking and physical examination are carried out to hair loss patient 170: wherein male 130 (76.5%), female 40
(23.5%), male: female 3.25:1, age of onset are 15-66 year old, are averaged 28.7 years old, wherein < 20 years old 40 (23.5%),
20-40 years old 110 (64.7%), > 40 years old 20 (11.8%), the course of disease -6 years 2 weeks, case was respectively alopecia areata 92
(54.1%), general alopecia 3 (1.8%), whole alopecia 19 (11.2%), other type baldnesses 56 (32.9%).
Laboratory inspection item: skin rash typus, alopecia involvement face are focused in blood routine, total LgE and erythrocyte sedimentation rate, scalp clinical examination
Product, presence or absence of tufted hair etc., skin microscopy observes emphatically hair follicle situation, and whether there is or not disconnected hair and new piliations, and suffers to 10
The fash blister liquid of person carries out Bacteria Culture and determination of drug sensitivity, is carried out according to the scalp of patient involvement area and skin rash typus
Clinical severity evaluation: alopecia area≤5%, 5% < alopecia area≤10% or volume useless fellow, alopecia area are greater than
10%,
Scalp biopsy and pathologic finding: 9 patients carry out scalp biopsy and sign informed consent form, 2% lidocaine office
About 8mm × 6mm size tissue at skin lesion is cut after portion's anesthesia, slice carries out Hematoxylin-eosin (HE) dyeing.
2. clinical manifestation and diagnostic criteria
Alopecia areata: limitation patch shape alopecia occurs suddenly, by low, feature is that lesion scalp is normal, no inflammation
Disease, no conscious sympton.
General alopecia: whole body hair does not fall off person for general alopecia.
Whole alopecia: entire scalp and hair-care all falls off referred to as whole alopecia.
Other type baldnesses: such as traumatic alopecia, Cicatricial baldness.
This product treatment object is above four kinds.
3. therapeutic scheme and medication
Trial drug: the tablet being prepared according to 1 method of embodiment.
According to the severity of the state of an illness and the result of drug sensitive detection selection therapeutic scheme: light-duty patient per 6, daily 3
It is secondary oral, it moderate patient per 7, takes orally 3 times a day, 8 tablets once by the obvious person of scalp inflammation, takes orally 3 times a day, weekly or often
Assessment in two weeks is primary, until monthly paying a return visit after Morbidity control is satisfied.
Laboratory checks: blood routine examination is shown no obvious abnormalities, and 2 patient LgE increase, wherein 1 has atopic dermatitis
Medical history, erythrocyte sedimentation rate are without exception.
Pathologic finding and bacteria cultivation results: the visible hair follicle keratotic plug of pathologic finding, perifollicolar are shown in obvious neutrophil leucocyte
Infiltration, with Focal Lymphocytic Infiltration, lesion meets folliculitis decalvans, in 10 patients of secretion Bacteria Culture, 6 trouble
Person's positive bacterial culture, Bacteria Identification result are respectively staphylococcus aureus, Ke Shi citric acid bacillus, coagulase-negative grape
Coccus or aerobacteria, drug sensitivity tests show it is sensitive to Multiple Classes of Antibiotics, 4 patients look into bacterium feminine gender.
4. therapeutic effect
Curative effect judging standard:
Recovery from illness: abnormal alopecia stops, and alopecia capitis totalis area renewable hair is dense, pitch-black, density is normal；
Effective: abnormal alopecia stops, and alopecia capitis totalis area renewable hair is relatively normal slightly sparse；
Effective: abnormal alopecia stops, the new children's hair of alopecia capitis totalis area regeneration；
It is invalid: without improving or worse before and after alopeciaing therapeutic.
Treatment results are shown in Table 1, and total effective rate is healing, effective and effective summation.
The clinical observation on the therapeutic effect test result of 1 the traditional chinese medicine composition of the invention hair growth of table
| Case load | It cures | It is effective | Effectively | In vain | Total effective rate % | |
| Alopecia areata | 92 | 71 | 11 | 4 | 6 | 93.5 |
| Whole alopecia | 19 | 11 | 4 | 2 | 2 | 89.5 |
| General alopecia | 3 | 0 | 1 | 1 | 1 | 66.7 |
| Other type baldnesses | 56 | 35 | 13 | 3 | 5 | 91.1 |
As seen from the table: alopecia areata total effective rate is 93.5%, whole alopecia 89.5%, general alopecia 66.7%, and other types are bald
Hair is 91.1%, illustrates that the traditional chinese medicine composition of the invention has significant treatment for alopecia areata, whole alopecia, general alopecia and other type baldnesses
Effect, and have no any adverse reaction.Prove that the traditional chinese medicine composition of the invention is a kind of hair growth safely and effectively composition.
From the point of view of age composition, mental element and kidney deficiency and liver are a critically important cause of disease in all types of alopecia cases
And inducement, many patients feel that rhythm of life is fast, stress is big, lives irregular, body is in sub-health state, therefore is controlling
Using nourishing liver and kidney when treatment, QI invigorating supports honor, by the maintenance to whole body qi and blood liver kidney, fundamentally treats to it, can reach and control
Treat purpose.
The above description is only a preferred embodiment of the present invention, is merely illustrative for the purpose of the present invention, and not restrictive；
Those of ordinary skill in the art understand, can carry out many to it in the spirit and scope defined by the claims in the present invention and change
Become, modification or even equivalent change, but falls in protection scope of the present invention.
Claims (1)
1. a kind of method of the tablet for the Chinese medicine composition for preparing hair growth, which comprises the following steps:
(1) each bulk pharmaceutical chemicals are weighed by following weight parts: Radix Angelicae Sinensis 50g, mulberry fruit 30g, mulberry leaf 10g, fructus lycii 20g, fruit of glossy privet 45g,
Glutinous rehmannia 15g, Radix Astragali 40g, prepared fleece flower root 70g, cacumen biotae 25g, eclipta 45g, Rhizoma Chuanxiong 20g, Semen sesami nigrum 60g, Semen Cuscutae 35g,
Rehmannia glutinosa 55g, Caulis Spatholobi 40g；
(2) prepared fleece flower root of Radix Angelicae Sinensis, Rhizoma Chuanxiong, cacumen biotae and 1/3 parts by weight is placed in co-grinding in pulverizer, crosses 80 meshes,
Up to crude drug powder；
(3) by mulberry fruit, mulberry leaf, fructus lycii, the fruit of glossy privet, glutinous rehmannia, Radix Astragali, eclipta, Semen sesami nigrum, Semen Cuscutae, Rehmannia glutinosa, Caulis Spatholobi
And the prepared fleece flower root of remaining 2/3 parts by weight is set in extractor, is added 10 times of amount water to decoct twice, is decocted 2 hours every time, merges
Decoction liquor, decoction liquor filtering, filtrate are concentrated into relative density 1.00~1.30 to get medicinal extract；
(4) after mixing by starch and crude drug powder, with medicinal extract spraying granulation, the particle after drying is subjected to whole grain, after whole grain
The particle that can be sieved by No. two must not exceed 20%, and the fine powder without that can cross No. six sieves；
(5) particle after whole grain is mixed, incorporation time is 20 minutes, mixed whole grain is carried out tabletting later, often
Slice weight 0.3g；
(6) substrate is coated according to the sequence of sub-coat, sugarcoating layer, coloured sugarcoating layer, polishing, sugar coated tablet is subjected to plastic-aluminum
Packaging.
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| CN105616703A (en) * | 2016-02-26 | 2016-06-01 | 覃淑兰 | Traditional Chinese medicine composition for treating hair loss and preparation method thereof |
| CN105902778A (en) * | 2016-07-13 | 2016-08-31 | 江传国 | External applied medicine for treating alopecia |
| CN107050299A (en) * | 2016-12-09 | 2017-08-18 | 李晓光 | A kind of Chinese medicine preparation of scalp oil-control hair care |
| CN106692475A (en) * | 2017-02-13 | 2017-05-24 | 佛山市腾瑞医药科技有限公司 | Traditional Chinese medicine composition for treating alopecia as well as preparation method thereof |
| CN111956712A (en) * | 2020-08-20 | 2020-11-20 | 李春晖 | Traditional Chinese medicine formula for treating alopecia areata |
| CN116270855B (en) * | 2023-02-27 | 2024-05-10 | 宁波市中医院 | Traditional Chinese medicine composition for treating alopecia |
| CN116920027B (en) * | 2023-08-31 | 2024-09-27 | 乐泰药业有限公司 | Traditional Chinese medicine composition for treating cataract caused by liver-kidney yin deficiency and qi and blood stasis, and preparation method and quality control method thereof |
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| CN101129775A (en) * | 2007-09-07 | 2008-02-27 | 吴法超 | Medicine for treating phalacrosis and restoring hair |
| CN102228669B (en) * | 2011-06-14 | 2013-06-26 | 重庆顶尚生物制品有限责任公司 | Traditional Chinese medicine preparation for treating alopecia and preparation method thereof |
| CN103223117A (en) * | 2012-01-27 | 2013-07-31 | 吴舒克 | Oral liquid for hair growth and hair protection and production method |
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| CN101129775A (en) * | 2007-09-07 | 2008-02-27 | 吴法超 | Medicine for treating phalacrosis and restoring hair |
| CN102228669B (en) * | 2011-06-14 | 2013-06-26 | 重庆顶尚生物制品有限责任公司 | Traditional Chinese medicine preparation for treating alopecia and preparation method thereof |
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