CN102228669B - Traditional Chinese medicine preparation for treating alopecia and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating alopecia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating alopecia and a preparation method thereof. The traditional Chinese medicine preparation for treating alopecia of the invention is prepared from the following medicinal materials of, by weight, main drugs comprising 12-18 parts of angelica sinensis, 8-12 parts of radix rehmanniae recen, 8-12 parts of fructus ligustri lucidi, 8-12 parts of semen cuscutae, 8-12 parts of matrimony vine, 4-6 parts of Chinese honey locust, 12-18 parts of polygonum multiflorum, 8-12 parts of semen sesami nigrum, 8-12 parts of ginger, 4-6parts of eclipta, 8-12 parts of cacumen biotae, 12-18 parts of mulberry, 8-12 parts of fructus cnidiiand, and 3-5 parts of borneol, and adjuvants of emu oil and alligator oil, wherein mass concentration of emu oil in the traditional Chinese medicine preparation is 4%-6%, and mass concentration of alligator oil in the traditional Chinese medicine preparation is 6%-8%. The preparation of the invention has efficacies of tonifying qi and nourishing the blood, promoting blood circulation and removing blood stasis, stimulating the menstrual flow and promoting blood circulation, breeding and nourishing hair, dispelling wind and arresting itching, activating occlusive hair follicle, and promoting hair regeneration. In addition, inflammation of scrubbing place can be avoided, and scar and ecchymosis formation rate is low.
Description
Technical field
The invention belongs to Chinese patent drug technique field, be specifically related to Chinese medicine preparation of a kind of hair growth and preparation method thereof.
Background technology
The prescription drug of hair growth mainly contains minoxidil, Finasteride etc.Use minoxidil easily to produce drug dependence, must ceaselessly use could be anti-loss, and such medicine be not suitable for period of pregnancy the women or women breast-feeding their children use, this class medicine reduces blood pressure in addition in addition, accelerates the side effect of heart beating.Finasteride is a kind of tablet form prescription drugs, and approximately want one month course for the treatment of, but side effect is larger, can reduce sex hormones secretion, and can cause lower part of the body pudendum pain.This two classes drug price is also more expensive simultaneously.At present the external preparation for the Chinese medicine of alopecia all exists shortcoming not fully up to expectations, and external preparation is coated on scalp can stop up hair follicle, thereby can cause that the hair follicle inflammation forms the cicatrix ecchymosis.
Summary of the invention
The technical problem to be solved in the present invention is to provide Chinese medicine preparation of a kind of hair growth that prevents the hair follicle inflammation and preparation method thereof.
In order to solve the problems of the technologies described above, the invention provides following technical scheme: a kind of Chinese medicine preparation of hair growth, this medicament are topical agent, and topical agent is made by the medicinal raw material of following weight portion:
Principal agent: 12～18 parts of Radix Angelicae Sinensis, 8～12 parts of Radix Rehmanniae, 8～12 parts of Fructus Ligustri Lucidi, 8～12 parts of Semen Cuscutae, 8～12 parts of Fructus Lyciis, Fructus Gleditsia 4～6,12～18 parts of Radix Polygoni Multiflori, 8～12 parts of Semen Sesami Nigrums, 8～12 parts, Rhizoma Zingiberis Recens, 4～6 parts of Herba Ecliptaes, 8～12 parts of Cacumen Platycladis, 12～18 parts of Fructus Mori, 8～12 parts of Fructus Cnidiis, 3～5 parts of Borneolum Syntheticums;
Accessory drugs: fat of Oromaius norvaehollandeae and alligator oil, wherein, the mass concentration of fat of Oromaius norvaehollandeae in Chinese medicine preparation is 4%～6%, the mass concentration of alligator oil in Chinese medicine preparation is 6%～8%.
Comprise the following steps:
A, Radix Rehmanniae, Fructus Ligustri Lucidi, Semen Cuscutae, Fructus Lycii, Fructus Gleditsia, Radix Polygoni Multiflori, Rhizoma Zingiberis Recens, Herba Ecliptae, Cacumen Platycladi, Fructus Mori, Fructus Cnidii, borneol and grinding is standby;
B, ground powder is added the rotary evaporation bottle, then add volumetric concentration 60% ethanol, vacuum back-flow, extraction is collected with refluxing the liquid that obtains and is again added the rotary evaporation bottle, and extraction, obtain the liquid I again;
C, the liquid I is filtered, remove residue, standing 48 hours, get the supernatant, get liquid;
D, to pulverize Radix Angelicae Sinensis with volumetric concentration be 70% soak with ethanol 3～7 days, and the consumption of 70% ethanol is 2～3 times of Radix Angelicae Sinensis quality, with the soak filtration, gets the filtrate III standby;
E, Semen Sesami Nigrum is smashed to pieces with the soak with ethanol of volumetric concentration 75% 3～7 days, the consumption of 75% ethanol is 2～3 times of Semen Sesami Nigrum quality, and soak is filtered, and gets the filtrate IV standby;
F, filtrate III and IV are merged, then adding fat of Oromaius norvaehollandeae, alligator oil and volumetric concentration is 95% ethanol, makes the quality final concentration of fat of Oromaius norvaehollandeae in medicinal liquid reach 4%～6%, the quality final concentration reach 6%～8%, the quality final concentration of ethanol reaches 70%～80% and get final product.
In order to realize better the present invention, the weight portion proportion optimization of described principal agent: 15 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Fructus Ligustri Lucidi, 10 parts of Semen Cuscutae, 10 parts of Fructus Lyciis, 5 parts, Fructus Gleditsia, 15 parts of Radix Polygoni Multiflori, 10 parts of Semen Sesami Nigrums, 10 parts, Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of Cacumen Platycladis, 15 parts of Fructus Mori, 10 parts of Fructus Cnidiis, 4 parts of Borneolum Syntheticums.
In order to realize better the present invention, the weight portion proportioning of accessory drugs is: the mass concentration of described fat of Oromaius norvaehollandeae in Chinese medicine preparation is 5%, and the mass concentration of alligator oil in Chinese medicine preparation is 7%.
Using method during medicine composite for curing alopecia of the present invention is: dip medicine of the present invention with cotton balls, and wiping alopecia place repeatedly, every day, respectively once, one month was a course for the treatment of sooner or later.
Medical material introduction in the present invention:
Radix Angelicae Sinensis: sweet in the mouth, suffering, warm in nature; Can enrich blood, invigorate blood circulation, regulating menstruation, pain relieving, intestine moistening; Can the promoting blood circulation and detumescence pain relieving, again can tonic blood and growing muscle, therefore also commonly used by the surgery ulcer sores.
Radix Rehmanniae: clearing up internal heat by using drugs of bitter in taste and cold in nature, Gan Hanzhi moistens yin nourishing, and the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, intestine moistening is arranged; Radix Rehmanniae Preparata sweet in the mouth tepor matter profit enters Liver and kidney two warps, both kind YIN nourishing of enriching blood, can mend again lean with, cure mainly the cloudy disease of losing oligospermia of blood deficiency.
Fructus Ligustri Lucidi: liver and kidney tonifying, clearind deficient heat makes eye bright; Be used for the hepatic and renal YIN deficiency, soreness of waist tinnitus, early whitening of beard and hair; Unseeing, poor vision; Fever due to yin deficiency.
Semen Cuscutae: Xin Gan is flat; The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity Gu the tire stopping leak is controlled the hemorrhoid bottoms pain of itching and nibbled as worm, is controlled eyebrow and is refined the tinea skin ulcer.
Fructus Lycii: control hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight; Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Fructus Gleditsia: expelling phlegm for arresting cough, logical the closing of having one's ideas straightened out, parasite killing eliminating stagnation; Cure mainly the productive cough dyspnea with fullness of the chest, the apoplexy locked mouth, accumulation and obstruction of sputum, coma in silence, epilepsy, sore throat, constipation and anuresis, carbuncle scabies; Use its hair washing, can alleviate alopecia, poliosis situation.
Radix Polygoni Multiflori is the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb., slightly warm in nature, and sweet in the mouth, puckery is returned liver, kidney channel, has enrich and benefit essence and blood, and nourishing the liver is calmed the nerves, bone and muscle strengthening, the function of the crow palpus that reinforces the kidney.
Rhizoma Zingiberis Recens is the fresh rhizome of Zingiberaceae herbaceos perennial Rhizoma Zingiberis Recens, Jiang Hanyou volatility (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone and zingerol, have invigorate blood circulation, the function such as cold relieving, dehumidifying, diaphoresis.
Herba Ecliptae: English Herba Ecluptae by name, be the dry aerial parts of feverfew Eclipta prostrata Eclipta prostrata L., sweet in the mouth, acid, cold, return kidney, Liver Channel, have nourishing the liver and kidney, the effect of cooling blood for hemostasis.
Cacumen Platycladi: be the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco, bitter in the mouth, puckery, cold is returned lung, liver, spleen channel, has cooling blood for hemostasis, the effect of growing and blacking hair.
Fructus Mori: be the mature fruit of Moraceae deciduous tree mulberry, cold nature enters the heart, liver, kidney channel, is strengthening by means of tonics, the good fruit of the heart nourishing and intellengence improving.Have the liver and the kidney tonifying, the effect such as the intestine moistening of promoting the production of body fluid, black hair make eye bright.
Fructus Cnidii: acrid in the mouth is cool, returns kidney channel, warming the kidney to activate YANG is arranged, dispels the wind, the effect of dampness, killing parasites for relieving itching, treating skin scabies eczema.
Borneolum Syntheticum: waking up the patient from unconsciousness by clearing away heat, refreshment can activate inaccessible hair follicle, promotes hair growth.
Fat of Oromaius norvaehollandeae: be the animal oil that extract from the Dromaius novaehollandiae that grows up with it, have the vigor that promotes skin follicle and the effect that promotes the growth of skin and hair.
Alligator oil: the physicochemical property of alligator oil and body fat are close especially, thereby have good permeability, and very easily admit for human body and absorb, have blood circulation promoting and blood stasis dispelling, active cell regeneration function, accelerate metabolism, impel Skin Cell to accelerate the effect of succession of the old by the new.
Compared with prior art, the invention has the advantages that: adopt the natural Chinese medicinal herb formula, have that benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, dysmenorrhea are invigorated blood circulation, a hair growth promoting hair care, dispelling wind for relieving itching, the inaccessible hair follicle of activation, promote the effect of hair regeneration; Avoid wiping place inflammation, cicatrix ecchymosis formation rate is low.
The specific embodiment
Embodiment 1 optimization formula of the present invention
Principal agent is 15 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Fructus Ligustri Lucidi, 10 parts of Semen Cuscutae, 10 parts of Fructus Lyciis, 5 parts, Fructus Gleditsia, 15 parts of Radix Polygoni Multiflori, 10 parts of Semen Sesami Nigrums, 10 parts, Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of Cacumen Platycladis, 15 parts of Fructus Mori, 10 parts of Fructus Cnidiis, 4 parts of Borneolum Syntheticums.Adjuvant is: fat of Oromaius norvaehollandeae and alligator oil, and wherein, the mass concentration of fat of Oromaius norvaehollandeae in Chinese medicine preparation is 5%, the mass concentration of alligator oil in Chinese medicine preparation is 7%.
Embodiment 2 preparation method of the present invention
Get 15 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Fructus Ligustri Lucidi, 10 parts of Semen Cuscutae, 10 parts of Fructus Lyciis, 5 parts, Fructus Gleditsia, 15 parts of Radix Polygoni Multiflori, 10 parts of Semen Sesami Nigrums, 10 parts, Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of Cacumen Platycladis, 15 parts of Fructus Mori, 10 parts of Fructus Cnidiis, 4 parts of Borneolum Syntheticums;
A, Radix Rehmanniae, Fructus Ligustri Lucidi, Semen Cuscutae, Fructus Lycii, Fructus Gleditsia, Radix Polygoni Multiflori, Rhizoma Zingiberis Recens, Herba Ecliptae, Cacumen Platycladi, Fructus Mori, Fructus Cnidii, borneol and grinding is standby;
B, ground powder is added the rotary evaporation bottle, then add volumetric concentration 60% ethanol, vacuum back-flow, extraction is collected with refluxing the liquid that obtains and is again added the rotary evaporation bottle, and extraction, obtain the liquid I again;
C, the liquid I is filtered, remove residue, standing 48 hours, get the supernatant, get liquid;
D, to pulverize Radix Angelicae Sinensis with volumetric concentration be 70% soak with ethanol 3～7 days, and the consumption of 70% ethanol is 2～3 times of Radix Angelicae Sinensis quality, with the soak filtration, gets the filtrate III standby;
E, Semen Sesami Nigrum is smashed to pieces with the soak with ethanol of volumetric concentration 75% 3～7 days, the consumption of 75% ethanol is 2～3 times of Semen Sesami Nigrum quality, and soak is filtered, and gets the filtrate IV standby;
F, filtrate III and IV are merged, then adding fat of Oromaius norvaehollandeae, alligator oil and volumetric concentration is 95% ethanol, makes the quality final concentration of fat of Oromaius norvaehollandeae in medicinal liquid reach 4%～6%, the quality final concentration reach 6%～8%, the quality final concentration of ethanol reaches 70%～80% and get final product.
Embodiment 3 application of the present invention
Using method of the present invention is: dip medicine of the present invention with cotton balls, and wiping alopecia place repeatedly, every day, respectively once, one month was a course for the treatment of sooner or later.
With the pharmaceutical composition that embodiment 2 is prepared, 103 hair loss patients are treated, wherein, male's 56 examples, women's 47 examples, the age is 20～57 years old, and 36 years old mean age, alopecia areata, alopecia universalis, alopecia totalis account for 53 examples, and seborrheic alopecia accounts for 50 examples.All patients were using this Chinese medicine preparation front 3 months, did not use the other drug treatment.Use this Chinese medicine preparation after three courses for the treatment of, alopecia areata, alopecia universalis, alopecia totalis recovery from illness 36 examples, effective 13 examples, invalid 4 examples, total effective rate is 92.4%, wiping medicine place has no inflammation and obvious cicatrix ecchymosis; Seborrheic alopecia recovery from illness 38 examples, effective 10 examples, invalid 2 examples, total effective rate is 96%, wiping medicine place has no inflammation and obvious cicatrix ecchymosis.
The criterion of curative effect is as follows:
Recovery from illness: hair stops coming off, and new regeneration reaches more than 70%, and sebum secretion obviously reduces;
Effectively: hair stops coming off, and new regeneration reaches more than 30%;
Invalid: hair continue to come off or, new below 30%.
The present invention has that benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, dysmenorrhea are invigorated blood circulation, hair growth promoting hair care, dispelling wind for relieving itching, the inaccessible hair follicle of activation, promotes the effect of hair regeneration; And have no inflammation and obvious cicatrix ecchymosis.
Claims (4)
1. the Chinese medicine preparation of a hair growth, is characterized in that this medicament is topical agent, and topical agent is made by the medicinal raw material of following weight portion:
Principal agent: 12～18 parts of Radix Angelicae Sinensis, 8～12 parts of Radix Rehmanniae, 8～12 parts of Fructus Ligustri Lucidi, 8～12 parts of Semen Cuscutae, 8～12 parts of Fructus Lyciis, Fructus Gleditsia 4～6,12～18 parts of Radix Polygoni Multiflori, 8～12 parts of Semen Sesami Nigrums, 8～12 parts, Rhizoma Zingiberis Recens, 4～6 parts of Herba Ecliptaes, 8～12 parts of Cacumen Platycladis, 12～18 parts of Fructus Mori, 8～12 parts of Fructus Cnidiis, 3～5 parts of Borneolum Syntheticums;
Accessory drugs: fat of Oromaius norvaehollandeae and alligator oil, wherein, the mass concentration of fat of Oromaius norvaehollandeae in Chinese medicine preparation is 4%～6%, the mass concentration of alligator oil in Chinese medicine preparation is 6%～8%.
2. the Chinese medicine preparation of hair growth as claimed in claim 1 is characterized in that the weight portion proportioning of described principal agent is:
15 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Fructus Ligustri Lucidi, 10 parts of Semen Cuscutae, 10 parts of Fructus Lyciis, 5 parts, Fructus Gleditsia, 15 parts of Radix Polygoni Multiflori, 10 parts of Semen Sesami Nigrums, 10 parts, Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of Cacumen Platycladis, 15 parts of Fructus Mori, 10 parts of Fructus Cnidiis, 4 parts of Borneolum Syntheticums.
3. the Chinese medicine preparation of hair growth as claimed in claim 1, it is characterized in that the weight portion proportioning of described accessory drugs is: the mass concentration of described fat of Oromaius norvaehollandeae in Chinese medicine preparation is 5%, the mass concentration of alligator oil in Chinese medicine preparation is 7%.
4. the preparation method of the Chinese medicine preparation of hair growth as claimed in claim 1 is characterized in that comprising the following steps:
A, Radix Rehmanniae, Fructus Ligustri Lucidi, Semen Cuscutae, Fructus Lycii, Fructus Gleditsia, Radix Polygoni Multiflori, Rhizoma Zingiberis Recens, Herba Ecliptae, Cacumen Platycladi, Fructus Mori, Fructus Cnidii, borneol and grinding is good standby;
B, ground powder is added the rotary evaporation bottle, then add volumetric concentration 60% ethanol, vacuum back-flow, extraction is collected with refluxing the liquid that obtains and is again added the rotary evaporation bottle, and extraction, obtain the liquid I again;
C, the liquid I is filtered, remove residue, standing 48 hours, get the supernatant, get liquid;
D, to pulverize Radix Angelicae Sinensis with volumetric concentration be 70% soak with ethanol 3～7 days, and the consumption of 70% ethanol is 2～3 times of Radix Angelicae Sinensis quality, with the soak filtration, gets the filtrate III standby;
E, Semen Sesami Nigrum is smashed to pieces with the soak with ethanol of volumetric concentration 75% 3～7 days, the consumption of 75% ethanol is 2～3 times of Semen Sesami Nigrum quality, and soak is filtered, and gets the filtrate IV standby;
F, filtrate III and IV are merged, then adding fat of Oromaius norvaehollandeae, alligator oil and volumetric concentration is 95% ethanol, makes the quality final concentration of fat of Oromaius norvaehollandeae in medicinal liquid reach 4%～6%, the quality final concentration reach 6%～8%, the quality final concentration of ethanol reaches 70%～80% and get final product.
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