CN102228669B - Traditional Chinese medicine preparation for treating alopecia and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating alopecia and preparation method thereof Download PDFInfo
- Publication number
- CN102228669B CN102228669B CN 201110157585 CN201110157585A CN102228669B CN 102228669 B CN102228669 B CN 102228669B CN 201110157585 CN201110157585 CN 201110157585 CN 201110157585 A CN201110157585 A CN 201110157585A CN 102228669 B CN102228669 B CN 102228669B
- Authority
- CN
- China
- Prior art keywords
- parts
- fructus
- chinese medicine
- medicine preparation
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 201000004384 alopecia Diseases 0.000 title abstract description 11
- 231100000360 alopecia Toxicity 0.000 title abstract description 10
- 210000000582 Semen Anatomy 0.000 claims abstract description 21
- 241000270728 Alligator Species 0.000 claims abstract description 15
- 229940079593 drugs Drugs 0.000 claims abstract description 9
- 240000003594 Eclipta prostrata Species 0.000 claims abstract description 8
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 4
- 229940116229 Borneol Drugs 0.000 claims abstract description 4
- 229930006709 borneol Natural products 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 42
- 239000007788 liquid Substances 0.000 claims description 15
- 230000003698 anagen phase Effects 0.000 claims description 12
- 230000003779 hair growth Effects 0.000 claims description 12
- 241000533849 Gleditsia Species 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 6
- 238000002390 rotary evaporation Methods 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000003860 topical agent Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 2
- 210000004369 Blood Anatomy 0.000 abstract description 16
- 239000008280 blood Substances 0.000 abstract description 16
- 210000004209 Hair Anatomy 0.000 abstract description 11
- 239000003921 oil Substances 0.000 abstract description 11
- 230000001737 promoting Effects 0.000 abstract description 11
- 230000017531 blood circulation Effects 0.000 abstract description 10
- 210000003780 Hair Follicle Anatomy 0.000 abstract description 7
- 206010061218 Inflammation Diseases 0.000 abstract description 7
- 230000004054 inflammatory process Effects 0.000 abstract description 7
- 206010014080 Ecchymosis Diseases 0.000 abstract description 6
- 208000003251 Pruritus Diseases 0.000 abstract description 5
- 241001289529 Fallopia multiflora Species 0.000 abstract description 3
- 230000003660 hair regeneration Effects 0.000 abstract description 3
- 240000000249 Morus alba Species 0.000 abstract description 2
- 235000008708 Morus alba Nutrition 0.000 abstract description 2
- 239000002671 adjuvant Substances 0.000 abstract description 2
- 230000000240 adjuvant Effects 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 238000005755 formation reaction Methods 0.000 abstract description 2
- 239000010776 emu oil Substances 0.000 abstract 2
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 241000931143 Gleditsia sinensis Species 0.000 abstract 1
- 240000001313 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 240000007329 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 230000003213 activating Effects 0.000 abstract 1
- 230000001488 breeding Effects 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000002175 menstrual Effects 0.000 abstract 1
- 231100000241 scar Toxicity 0.000 abstract 1
- 238000005201 scrubbing Methods 0.000 abstract 1
- 230000004936 stimulating Effects 0.000 abstract 1
- 210000003734 Kidney Anatomy 0.000 description 11
- 210000004185 Liver Anatomy 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 210000000214 Mouth Anatomy 0.000 description 7
- 210000000589 Cicatrix Anatomy 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 210000000936 Intestines Anatomy 0.000 description 3
- 210000003491 Skin Anatomy 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 206010063409 Acarodermatitis Diseases 0.000 description 2
- 208000004631 Alopecia Areata Diseases 0.000 description 2
- 206010001766 Alopecia totalis Diseases 0.000 description 2
- 206010001767 Alopecia universalis Diseases 0.000 description 2
- 210000001124 Body Fluids Anatomy 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 235000009161 Espostoa lanata Nutrition 0.000 description 2
- 240000001624 Espostoa lanata Species 0.000 description 2
- 241000201295 Euphrasia Species 0.000 description 2
- DBEPLOCGEIEOCV-WSBQPABSSA-N Finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 2
- 210000002216 Heart Anatomy 0.000 description 2
- 210000001624 Hip Anatomy 0.000 description 2
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Loniten Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 2
- 229960003632 Minoxidil Drugs 0.000 description 2
- 210000003205 Muscles Anatomy 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 208000008425 Protein Deficiency Diseases 0.000 description 2
- 208000005687 Scabies Diseases 0.000 description 2
- 241000447727 Scabies Species 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000003203 everyday Effects 0.000 description 2
- 229960004039 finasteride Drugs 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000002440 hepatic Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 244000045947 parasites Species 0.000 description 2
- 239000000955 prescription drug Substances 0.000 description 2
- 230000000268 renotropic Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 231100000486 side effect Toxicity 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- 230000001256 tonic Effects 0.000 description 2
- 235000015961 tonic Nutrition 0.000 description 2
- GTLGHKNKLRZSMO-UHFFFAOYSA-N 4-(3-hydroxybutyl)-2-methoxyphenol Chemical compound COC1=CC(CCC(C)O)=CC=C1O GTLGHKNKLRZSMO-UHFFFAOYSA-N 0.000 description 1
- 206010049865 Achromotrichia acquired Diseases 0.000 description 1
- 210000000577 Adipose Tissue Anatomy 0.000 description 1
- 206010003549 Asthenia Diseases 0.000 description 1
- 206010003883 Azoospermia Diseases 0.000 description 1
- 210000000988 Bone and Bones Anatomy 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000218691 Cupressaceae Species 0.000 description 1
- 241000668709 Dipterocarpus costatus Species 0.000 description 1
- 241000271571 Dromaius novaehollandiae Species 0.000 description 1
- 206010013663 Drug dependence Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000005679 Eczema Diseases 0.000 description 1
- 206010015037 Epilepsy Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 210000004709 Eyebrows Anatomy 0.000 description 1
- 208000002287 Hemorrhoids Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010024855 Loss of consciousness Diseases 0.000 description 1
- 210000004072 Lung Anatomy 0.000 description 1
- 230000036740 Metabolism Effects 0.000 description 1
- 241000218231 Moraceae Species 0.000 description 1
- 208000008634 Oligospermia Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 240000002924 Platycladus orientalis Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 210000004761 Scalp Anatomy 0.000 description 1
- 210000002374 Sebum Anatomy 0.000 description 1
- 210000004927 Skin cells Anatomy 0.000 description 1
- 206010040943 Skin ulcer Diseases 0.000 description 1
- 210000000952 Spleen Anatomy 0.000 description 1
- 210000003802 Sputum Anatomy 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 229960000716 TONICS Drugs 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 206010068760 Ulcers Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 206010052769 Vertigos Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047531 Visual acuity reduced Diseases 0.000 description 1
- OJYLAHXKWMRDGS-UHFFFAOYSA-N Zingerone Chemical compound COC1=CC(CCC(C)=O)=CC=C1O OJYLAHXKWMRDGS-UHFFFAOYSA-N 0.000 description 1
- 241000234299 Zingiberaceae Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004027 cells Anatomy 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 201000004624 dermatitis Diseases 0.000 description 1
- 231100001003 eczema Toxicity 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 235000019525 fullness Nutrition 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 230000010247 heart contraction Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000035786 metabolism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000414 obstructive Effects 0.000 description 1
- 230000036616 oligospermia Effects 0.000 description 1
- 231100000528 oligospermia Toxicity 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000001105 regulatory Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 230000002618 waking Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000002087 whitening Effects 0.000 description 1
Abstract
The invention discloses a traditional Chinese medicine preparation for treating alopecia and a preparation method thereof. The traditional Chinese medicine preparation for treating alopecia of the invention is prepared from the following medicinal materials of, by weight, main drugs comprising 12-18 parts of angelica sinensis, 8-12 parts of radix rehmanniae recen, 8-12 parts of fructus ligustri lucidi, 8-12 parts of semen cuscutae, 8-12 parts of matrimony vine, 4-6 parts of Chinese honey locust, 12-18 parts of polygonum multiflorum, 8-12 parts of semen sesami nigrum, 8-12 parts of ginger, 4-6parts of eclipta, 8-12 parts of cacumen biotae, 12-18 parts of mulberry, 8-12 parts of fructus cnidiiand, and 3-5 parts of borneol, and adjuvants of emu oil and alligator oil, wherein mass concentration of emu oil in the traditional Chinese medicine preparation is 4%-6%, and mass concentration of alligator oil in the traditional Chinese medicine preparation is 6%-8%. The preparation of the invention has efficacies of tonifying qi and nourishing the blood, promoting blood circulation and removing blood stasis, stimulating the menstrual flow and promoting blood circulation, breeding and nourishing hair, dispelling wind and arresting itching, activating occlusive hair follicle, and promoting hair regeneration. In addition, inflammation of scrubbing place can be avoided, and scar and ecchymosis formation rate is low.
Description
Technical field
The invention belongs to Chinese patent drug technique field, be specifically related to Chinese medicine preparation of a kind of hair growth and preparation method thereof.
Background technology
The prescription drug of hair growth mainly contains minoxidil, Finasteride etc.Use minoxidil easily to produce drug dependence, must ceaselessly use could be anti-loss, and such medicine be not suitable for period of pregnancy the women or women breast-feeding their children use, this class medicine reduces blood pressure in addition in addition, accelerates the side effect of heart beating.Finasteride is a kind of tablet form prescription drugs, and approximately want one month course for the treatment of, but side effect is larger, can reduce sex hormones secretion, and can cause lower part of the body pudendum pain.This two classes drug price is also more expensive simultaneously.At present the external preparation for the Chinese medicine of alopecia all exists shortcoming not fully up to expectations, and external preparation is coated on scalp can stop up hair follicle, thereby can cause that the hair follicle inflammation forms the cicatrix ecchymosis.
Summary of the invention
The technical problem to be solved in the present invention is to provide Chinese medicine preparation of a kind of hair growth that prevents the hair follicle inflammation and preparation method thereof.
In order to solve the problems of the technologies described above, the invention provides following technical scheme: a kind of Chinese medicine preparation of hair growth, this medicament are topical agent, and topical agent is made by the medicinal raw material of following weight portion:
Principal agent: 12～18 parts of Radix Angelicae Sinensis, 8～12 parts of Radix Rehmanniae, 8～12 parts of Fructus Ligustri Lucidi, 8～12 parts of Semen Cuscutae, 8～12 parts of Fructus Lyciis, Fructus Gleditsia 4～6,12～18 parts of Radix Polygoni Multiflori, 8～12 parts of Semen Sesami Nigrums, 8～12 parts, Rhizoma Zingiberis Recens, 4～6 parts of Herba Ecliptaes, 8～12 parts of Cacumen Platycladis, 12～18 parts of Fructus Mori, 8～12 parts of Fructus Cnidiis, 3～5 parts of Borneolum Syntheticums;
Accessory drugs: fat of Oromaius norvaehollandeae and alligator oil, wherein, the mass concentration of fat of Oromaius norvaehollandeae in Chinese medicine preparation is 4%～6%, the mass concentration of alligator oil in Chinese medicine preparation is 6%～8%.
Comprise the following steps:
A, Radix Rehmanniae, Fructus Ligustri Lucidi, Semen Cuscutae, Fructus Lycii, Fructus Gleditsia, Radix Polygoni Multiflori, Rhizoma Zingiberis Recens, Herba Ecliptae, Cacumen Platycladi, Fructus Mori, Fructus Cnidii, borneol and grinding is standby;
B, ground powder is added the rotary evaporation bottle, then add volumetric concentration 60% ethanol, vacuum back-flow, extraction is collected with refluxing the liquid that obtains and is again added the rotary evaporation bottle, and extraction, obtain the liquid I again;
C, the liquid I is filtered, remove residue, standing 48 hours, get the supernatant, get liquid;
D, to pulverize Radix Angelicae Sinensis with volumetric concentration be 70% soak with ethanol 3～7 days, and the consumption of 70% ethanol is 2～3 times of Radix Angelicae Sinensis quality, with the soak filtration, gets the filtrate III standby;
E, Semen Sesami Nigrum is smashed to pieces with the soak with ethanol of volumetric concentration 75% 3～7 days, the consumption of 75% ethanol is 2～3 times of Semen Sesami Nigrum quality, and soak is filtered, and gets the filtrate IV standby;
F, filtrate III and IV are merged, then adding fat of Oromaius norvaehollandeae, alligator oil and volumetric concentration is 95% ethanol, makes the quality final concentration of fat of Oromaius norvaehollandeae in medicinal liquid reach 4%～6%, the quality final concentration reach 6%～8%, the quality final concentration of ethanol reaches 70%～80% and get final product.
In order to realize better the present invention, the weight portion proportion optimization of described principal agent: 15 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Fructus Ligustri Lucidi, 10 parts of Semen Cuscutae, 10 parts of Fructus Lyciis, 5 parts, Fructus Gleditsia, 15 parts of Radix Polygoni Multiflori, 10 parts of Semen Sesami Nigrums, 10 parts, Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of Cacumen Platycladis, 15 parts of Fructus Mori, 10 parts of Fructus Cnidiis, 4 parts of Borneolum Syntheticums.
In order to realize better the present invention, the weight portion proportioning of accessory drugs is: the mass concentration of described fat of Oromaius norvaehollandeae in Chinese medicine preparation is 5%, and the mass concentration of alligator oil in Chinese medicine preparation is 7%.
Using method during medicine composite for curing alopecia of the present invention is: dip medicine of the present invention with cotton balls, and wiping alopecia place repeatedly, every day, respectively once, one month was a course for the treatment of sooner or later.
Medical material introduction in the present invention:
Radix Angelicae Sinensis: sweet in the mouth, suffering, warm in nature; Can enrich blood, invigorate blood circulation, regulating menstruation, pain relieving, intestine moistening; Can the promoting blood circulation and detumescence pain relieving, again can tonic blood and growing muscle, therefore also commonly used by the surgery ulcer sores.
Radix Rehmanniae: clearing up internal heat by using drugs of bitter in taste and cold in nature, Gan Hanzhi moistens yin nourishing, and the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, intestine moistening is arranged; Radix Rehmanniae Preparata sweet in the mouth tepor matter profit enters Liver and kidney two warps, both kind YIN nourishing of enriching blood, can mend again lean with, cure mainly the cloudy disease of losing oligospermia of blood deficiency.
Fructus Ligustri Lucidi: liver and kidney tonifying, clearind deficient heat makes eye bright; Be used for the hepatic and renal YIN deficiency, soreness of waist tinnitus, early whitening of beard and hair; Unseeing, poor vision; Fever due to yin deficiency.
Semen Cuscutae: Xin Gan is flat; The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity Gu the tire stopping leak is controlled the hemorrhoid bottoms pain of itching and nibbled as worm, is controlled eyebrow and is refined the tinea skin ulcer.
Fructus Lycii: control hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight; Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Fructus Gleditsia: expelling phlegm for arresting cough, logical the closing of having one's ideas straightened out, parasite killing eliminating stagnation; Cure mainly the productive cough dyspnea with fullness of the chest, the apoplexy locked mouth, accumulation and obstruction of sputum, coma in silence, epilepsy, sore throat, constipation and anuresis, carbuncle scabies; Use its hair washing, can alleviate alopecia, poliosis situation.
Radix Polygoni Multiflori is the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb., slightly warm in nature, and sweet in the mouth, puckery is returned liver, kidney channel, has enrich and benefit essence and blood, and nourishing the liver is calmed the nerves, bone and muscle strengthening, the function of the crow palpus that reinforces the kidney.
Rhizoma Zingiberis Recens is the fresh rhizome of Zingiberaceae herbaceos perennial Rhizoma Zingiberis Recens, Jiang Hanyou volatility (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone and zingerol, have invigorate blood circulation, the function such as cold relieving, dehumidifying, diaphoresis.
Herba Ecliptae: English Herba Ecluptae by name, be the dry aerial parts of feverfew Eclipta prostrata Eclipta prostrata L., sweet in the mouth, acid, cold, return kidney, Liver Channel, have nourishing the liver and kidney, the effect of cooling blood for hemostasis.
Cacumen Platycladi: be the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco, bitter in the mouth, puckery, cold is returned lung, liver, spleen channel, has cooling blood for hemostasis, the effect of growing and blacking hair.
Fructus Mori: be the mature fruit of Moraceae deciduous tree mulberry, cold nature enters the heart, liver, kidney channel, is strengthening by means of tonics, the good fruit of the heart nourishing and intellengence improving.Have the liver and the kidney tonifying, the effect such as the intestine moistening of promoting the production of body fluid, black hair make eye bright.
Fructus Cnidii: acrid in the mouth is cool, returns kidney channel, warming the kidney to activate YANG is arranged, dispels the wind, the effect of dampness, killing parasites for relieving itching, treating skin scabies eczema.
Borneolum Syntheticum: waking up the patient from unconsciousness by clearing away heat, refreshment can activate inaccessible hair follicle, promotes hair growth.
Fat of Oromaius norvaehollandeae: be the animal oil that extract from the Dromaius novaehollandiae that grows up with it, have the vigor that promotes skin follicle and the effect that promotes the growth of skin and hair.
Alligator oil: the physicochemical property of alligator oil and body fat are close especially, thereby have good permeability, and very easily admit for human body and absorb, have blood circulation promoting and blood stasis dispelling, active cell regeneration function, accelerate metabolism, impel Skin Cell to accelerate the effect of succession of the old by the new.
Compared with prior art, the invention has the advantages that: adopt the natural Chinese medicinal herb formula, have that benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, dysmenorrhea are invigorated blood circulation, a hair growth promoting hair care, dispelling wind for relieving itching, the inaccessible hair follicle of activation, promote the effect of hair regeneration; Avoid wiping place inflammation, cicatrix ecchymosis formation rate is low.
The specific embodiment
Embodiment 1 optimization formula of the present invention
Principal agent is 15 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Fructus Ligustri Lucidi, 10 parts of Semen Cuscutae, 10 parts of Fructus Lyciis, 5 parts, Fructus Gleditsia, 15 parts of Radix Polygoni Multiflori, 10 parts of Semen Sesami Nigrums, 10 parts, Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of Cacumen Platycladis, 15 parts of Fructus Mori, 10 parts of Fructus Cnidiis, 4 parts of Borneolum Syntheticums.Adjuvant is: fat of Oromaius norvaehollandeae and alligator oil, and wherein, the mass concentration of fat of Oromaius norvaehollandeae in Chinese medicine preparation is 5%, the mass concentration of alligator oil in Chinese medicine preparation is 7%.
Embodiment 2 preparation method of the present invention
Get 15 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Fructus Ligustri Lucidi, 10 parts of Semen Cuscutae, 10 parts of Fructus Lyciis, 5 parts, Fructus Gleditsia, 15 parts of Radix Polygoni Multiflori, 10 parts of Semen Sesami Nigrums, 10 parts, Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of Cacumen Platycladis, 15 parts of Fructus Mori, 10 parts of Fructus Cnidiis, 4 parts of Borneolum Syntheticums;
A, Radix Rehmanniae, Fructus Ligustri Lucidi, Semen Cuscutae, Fructus Lycii, Fructus Gleditsia, Radix Polygoni Multiflori, Rhizoma Zingiberis Recens, Herba Ecliptae, Cacumen Platycladi, Fructus Mori, Fructus Cnidii, borneol and grinding is standby;
B, ground powder is added the rotary evaporation bottle, then add volumetric concentration 60% ethanol, vacuum back-flow, extraction is collected with refluxing the liquid that obtains and is again added the rotary evaporation bottle, and extraction, obtain the liquid I again;
C, the liquid I is filtered, remove residue, standing 48 hours, get the supernatant, get liquid;
D, to pulverize Radix Angelicae Sinensis with volumetric concentration be 70% soak with ethanol 3～7 days, and the consumption of 70% ethanol is 2～3 times of Radix Angelicae Sinensis quality, with the soak filtration, gets the filtrate III standby;
E, Semen Sesami Nigrum is smashed to pieces with the soak with ethanol of volumetric concentration 75% 3～7 days, the consumption of 75% ethanol is 2～3 times of Semen Sesami Nigrum quality, and soak is filtered, and gets the filtrate IV standby;
F, filtrate III and IV are merged, then adding fat of Oromaius norvaehollandeae, alligator oil and volumetric concentration is 95% ethanol, makes the quality final concentration of fat of Oromaius norvaehollandeae in medicinal liquid reach 4%～6%, the quality final concentration reach 6%～8%, the quality final concentration of ethanol reaches 70%～80% and get final product.
Embodiment 3 application of the present invention
Using method of the present invention is: dip medicine of the present invention with cotton balls, and wiping alopecia place repeatedly, every day, respectively once, one month was a course for the treatment of sooner or later.
With the pharmaceutical composition that embodiment 2 is prepared, 103 hair loss patients are treated, wherein, male's 56 examples, women's 47 examples, the age is 20～57 years old, and 36 years old mean age, alopecia areata, alopecia universalis, alopecia totalis account for 53 examples, and seborrheic alopecia accounts for 50 examples.All patients were using this Chinese medicine preparation front 3 months, did not use the other drug treatment.Use this Chinese medicine preparation after three courses for the treatment of, alopecia areata, alopecia universalis, alopecia totalis recovery from illness 36 examples, effective 13 examples, invalid 4 examples, total effective rate is 92.4%, wiping medicine place has no inflammation and obvious cicatrix ecchymosis; Seborrheic alopecia recovery from illness 38 examples, effective 10 examples, invalid 2 examples, total effective rate is 96%, wiping medicine place has no inflammation and obvious cicatrix ecchymosis.
The criterion of curative effect is as follows:
Recovery from illness: hair stops coming off, and new regeneration reaches more than 70%, and sebum secretion obviously reduces;
Effectively: hair stops coming off, and new regeneration reaches more than 30%;
Invalid: hair continue to come off or, new below 30%.
The present invention has that benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, dysmenorrhea are invigorated blood circulation, hair growth promoting hair care, dispelling wind for relieving itching, the inaccessible hair follicle of activation, promotes the effect of hair regeneration; And have no inflammation and obvious cicatrix ecchymosis.
Claims (4)
1. the Chinese medicine preparation of a hair growth, is characterized in that this medicament is topical agent, and topical agent is made by the medicinal raw material of following weight portion:
Principal agent: 12～18 parts of Radix Angelicae Sinensis, 8～12 parts of Radix Rehmanniae, 8～12 parts of Fructus Ligustri Lucidi, 8～12 parts of Semen Cuscutae, 8～12 parts of Fructus Lyciis, Fructus Gleditsia 4～6,12～18 parts of Radix Polygoni Multiflori, 8～12 parts of Semen Sesami Nigrums, 8～12 parts, Rhizoma Zingiberis Recens, 4～6 parts of Herba Ecliptaes, 8～12 parts of Cacumen Platycladis, 12～18 parts of Fructus Mori, 8～12 parts of Fructus Cnidiis, 3～5 parts of Borneolum Syntheticums;
Accessory drugs: fat of Oromaius norvaehollandeae and alligator oil, wherein, the mass concentration of fat of Oromaius norvaehollandeae in Chinese medicine preparation is 4%～6%, the mass concentration of alligator oil in Chinese medicine preparation is 6%～8%.
2. the Chinese medicine preparation of hair growth as claimed in claim 1 is characterized in that the weight portion proportioning of described principal agent is:
15 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Fructus Ligustri Lucidi, 10 parts of Semen Cuscutae, 10 parts of Fructus Lyciis, 5 parts, Fructus Gleditsia, 15 parts of Radix Polygoni Multiflori, 10 parts of Semen Sesami Nigrums, 10 parts, Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of Cacumen Platycladis, 15 parts of Fructus Mori, 10 parts of Fructus Cnidiis, 4 parts of Borneolum Syntheticums.
3. the Chinese medicine preparation of hair growth as claimed in claim 1, it is characterized in that the weight portion proportioning of described accessory drugs is: the mass concentration of described fat of Oromaius norvaehollandeae in Chinese medicine preparation is 5%, the mass concentration of alligator oil in Chinese medicine preparation is 7%.
4. the preparation method of the Chinese medicine preparation of hair growth as claimed in claim 1 is characterized in that comprising the following steps:
A, Radix Rehmanniae, Fructus Ligustri Lucidi, Semen Cuscutae, Fructus Lycii, Fructus Gleditsia, Radix Polygoni Multiflori, Rhizoma Zingiberis Recens, Herba Ecliptae, Cacumen Platycladi, Fructus Mori, Fructus Cnidii, borneol and grinding is good standby;
B, ground powder is added the rotary evaporation bottle, then add volumetric concentration 60% ethanol, vacuum back-flow, extraction is collected with refluxing the liquid that obtains and is again added the rotary evaporation bottle, and extraction, obtain the liquid I again;
C, the liquid I is filtered, remove residue, standing 48 hours, get the supernatant, get liquid;
D, to pulverize Radix Angelicae Sinensis with volumetric concentration be 70% soak with ethanol 3～7 days, and the consumption of 70% ethanol is 2～3 times of Radix Angelicae Sinensis quality, with the soak filtration, gets the filtrate III standby;
E, Semen Sesami Nigrum is smashed to pieces with the soak with ethanol of volumetric concentration 75% 3～7 days, the consumption of 75% ethanol is 2～3 times of Semen Sesami Nigrum quality, and soak is filtered, and gets the filtrate IV standby;
F, filtrate III and IV are merged, then adding fat of Oromaius norvaehollandeae, alligator oil and volumetric concentration is 95% ethanol, makes the quality final concentration of fat of Oromaius norvaehollandeae in medicinal liquid reach 4%～6%, the quality final concentration reach 6%～8%, the quality final concentration of ethanol reaches 70%～80% and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110157585 CN102228669B (en) | 2011-06-14 | 2011-06-14 | Traditional Chinese medicine preparation for treating alopecia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110157585 CN102228669B (en) | 2011-06-14 | 2011-06-14 | Traditional Chinese medicine preparation for treating alopecia and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102228669A CN102228669A (en) | 2011-11-02 |
| CN102228669B true CN102228669B (en) | 2013-06-26 |
Family
ID=44841301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110157585 Active CN102228669B (en) | 2011-06-14 | 2011-06-14 | Traditional Chinese medicine preparation for treating alopecia and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102228669B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491181B (en) * | 2015-01-05 | 2019-01-15 | 哈尔滨快好药业有限公司 | A kind of Chinese medicine composition of hair growth and its preparation method and application |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755613B (en) * | 2012-06-25 | 2014-06-11 | 王苏明 | Traditional Chinese medicine preparation for treating alopecia |
| CN104013947A (en) * | 2014-06-27 | 2014-09-03 | 喻朝阳 | Hair-restorer spraying liquid of fresh medicine, fruit and vegetable ferments with effects of preventing hair loss and restoring hair and preparation method thereof |
| CN104324321A (en) * | 2014-10-08 | 2015-02-04 | 苏州市天灵中药饮片有限公司 | Formula and preparation method of alopecia treating traditional Chinese medicine |
| CN104382011A (en) * | 2014-10-24 | 2015-03-04 | 遵义博信科技咨询有限责任公司 | Traditional Chinese medicine composite capable of blacking hair and helping hair growth and preparation method thereof |
| CN105456514A (en) * | 2015-12-05 | 2016-04-06 | 重庆和术堂生物科技有限公司 | Anti-alopecia hair care agent |
| CN105521154A (en) * | 2015-12-05 | 2016-04-27 | 重庆和术堂生物科技有限公司 | Preparation method of anti-dropping hair conditioner |
| CN105411855A (en) * | 2015-12-24 | 2016-03-23 | 山东省化工研究院 | Medical dropping pill device and method for preparing brain strengthening and hair blacking dropping pills with same |
| CN105853291A (en) * | 2016-05-13 | 2016-08-17 | 申向阳 | Chinese herbal medicinal liquid shampoo |
| CN106138249A (en) * | 2016-08-12 | 2016-11-23 | 张彦优 | A kind of Chinese medicine composition with hair-growing effects |
| CN106214898A (en) * | 2016-08-12 | 2016-12-14 | 重庆顶尚生物制品有限责任公司 | Chinese medicine preparation for the treatment of poliosis and preparation method thereof |
| CN106236652A (en) * | 2016-08-29 | 2016-12-21 | 张悦辉 | A kind of hair-care essence liquid and preparation method thereof |
| CN108066274B (en) * | 2018-01-25 | 2021-03-30 | 深圳市大鳄生物科技股份有限公司 | Hair blackening compound and preparation method and application thereof |
| CN110251440A (en) * | 2019-08-06 | 2019-09-20 | 巩义市育发堂科贸有限公司 | Black dense Essence of one kind and preparation method thereof |
| CN110721238B (en) * | 2019-11-20 | 2021-11-02 | 上海华伊美化妆品有限公司 | Compound traditional Chinese medicine extract for fixing hair, preventing alopecia and removing dandruff as well as preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1613497A (en) * | 2004-07-24 | 2005-05-11 | 王�华 | Composite Chinese medicinal prescription for breeding and blackening hair |
| CN101513460B (en) * | 2009-04-03 | 2011-04-06 | 王国军 | Traditional Chinese medicine for curing alopecia |
-
2011
- 2011-06-14 CN CN 201110157585 patent/CN102228669B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1613497A (en) * | 2004-07-24 | 2005-05-11 | 王�华 | Composite Chinese medicinal prescription for breeding and blackening hair |
| CN101513460B (en) * | 2009-04-03 | 2011-04-06 | 王国军 | Traditional Chinese medicine for curing alopecia |
Non-Patent Citations (6)
| Title |
|---|
| 何慧英.脱发病的中医治疗及研究进展.《浙江中医学院学报》.2001,第25卷(第03期),77-78. |
| 宋兆友.常用皮肤病中药外用制剂介绍.《皮肤病与性病》.2006,第28卷(第01期),23-24. |
| 常用皮肤病中药外用制剂介绍;宋兆友;《皮肤病与性病》;20060330;第28卷(第01期);23-24 * |
| 江年琼等.鸸鹋的综合开发利用.《经济动物学报》.2006,第10卷(第02期),117-119. |
| 脱发病的中医治疗及研究进展;何慧英;《浙江中医学院学报》;20010622;第25卷(第03期);77-78 * |
| 鸸鹋的综合开发利用;江年琼等;《经济动物学报》;20060630;第10卷(第02期);117-119 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491181B (en) * | 2015-01-05 | 2019-01-15 | 哈尔滨快好药业有限公司 | A kind of Chinese medicine composition of hair growth and its preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102228669A (en) | 2011-11-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102228669B (en) | Traditional Chinese medicine preparation for treating alopecia and preparation method thereof | |
| CN102727855B (en) | Chinese medicinal composition for treating alopecia and poliosis | |
| CN105363015A (en) | Medicine composition for treating alopecia and preparation method of medicine composition | |
| CN101049494B (en) | Composition of medicine for treating alopecia and preparation method | |
| CN101336970B (en) | Chinese herbal medicine for treating and preventing poliosis and alopecia | |
| CN105055849A (en) | Traditional Chinese medicine extract capable of nourishing Yin and tonifying kidney as well as preparation method and application of traditional Chinese medicine extract | |
| CN101391047B (en) | Traditional Chinese medicine preparation for treating trichonosis | |
| CN104042877A (en) | Traditional Chinese medicinal composition for treating alopecia | |
| CN102335328B (en) | Chinese medicine oral preparation for hair growth and hair blackening | |
| CN103750137B (en) | A kind of anti-loss white hair herbal cuisine | |
| CN110269911A (en) | For hair growth and the Chinese medicine preparation of changing white hair into black hair and preparation method thereof | |
| CN106177192B (en) | Bi-component compound medicine for treating head oil and dandruff and preparation method thereof | |
| CN101559034B (en) | Shampoo powder for promoting hair to regrow and preventing trichomadesis | |
| CN103920002A (en) | Hair growth agent and preparation method thereof | |
| CN105596861A (en) | Pill used for treating adverse reaction after CT enhancement scanning and preparation method | |
| CN101485875A (en) | Medicament composing prescription for preventing and treating alopecia and preparation method thereof | |
| CN104857288A (en) | Chinese herbal preparation for treating white hair and preparation method thereof | |
| CN104524179A (en) | Chinese herbal medicine used for treating head alopecia areata and hair loss | |
| CN104189593A (en) | Traditional Chinese medicine for treating premature graying of hair | |
| CN106214898A (en) | Chinese medicine preparation for the treatment of poliosis and preparation method thereof | |
| CN105727234A (en) | Traditional Chinese medicine composition for treating alopecia as well as preparation method and application of traditional Chinese medicine composition | |
| CN103202913B (en) | Pure traditional Chinese medicine composition with multi-effects of thickening hair, blackening hair and strengthening hair | |
| CN105920563A (en) | Pharmaceutical composition capable of promoting hair growth and preparation method thereof | |
| CN105853595A (en) | Medicinal composition for preventing alopecia and preparation method thereof | |
| CN105616999A (en) | Traditional Chinese medicine composition for treating alopecia areata |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |