CN101049494B - Composition of medicine for treating alopecia and preparation method - Google Patents
Composition of medicine for treating alopecia and preparation method Download PDFInfo
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- CN101049494B CN101049494B CN200710090594XA CN200710090594A CN101049494B CN 101049494 B CN101049494 B CN 101049494B CN 200710090594X A CN200710090594X A CN 200710090594XA CN 200710090594 A CN200710090594 A CN 200710090594A CN 101049494 B CN101049494 B CN 101049494B
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- 238000002360 preparation method Methods 0.000 title claims description 12
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Abstract
A Chinese medicine for treating alopesia is prepared from 11 Chinese-medicinal materials including Chinese angelica root, rehmannia root, black sesame, safflower, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to technical field of Chinese patent medicine, be specifically related to a kind of pharmaceutical composition for the treatment of alopecia and preparation method thereof.
Background technology
The prescription drug of treatment alopecia at present mainly contains minoxidil, Finasteride etc.Use minoxidil to be easy to generate drug dependence, the use that must not stop could be anti-loss, and such medicine be not suitable for period of pregnancy the women or women breast-feeding their children use, this class medicine brings high blood pressure down in addition in addition, accelerates the side effect of heart beating.Finasteride is a kind of tablet form prescription drugs, and approximately want one month course of treatment, but side effect is bigger, can reduce sex hormones secretion, and can cause lower part of the body pudendum pain.This two classes drug price is also more expensive simultaneously.
Summary of the invention
For overcoming treatment alopecia side effects of pharmaceutical drugs problem and reaching more effective therapeutic effect, the invention provides a kind of pharmaceutical composition for the treatment of alopecia and preparation method thereof.
The pharmaceutical composition of treatment alopecia of the present invention is made by the medicinal raw material of following weight portion proportioning:
Principal agent: 12～18 parts of Radix Angelicae Sinensis, 8～12 parts of Radix Rehmanniae, 8～12 parts of Radix Rehmanniae Preparata, 8～12 parts of Semen Sesami Nigrums, 12～18 parts of Radix Polygoni Multiflori, 4～6 parts on Flos Carthami, 8～12 parts of Radix Paeoniae Rubra, 8～12 parts in Rhizoma Zingiberis Recens, 4～6 parts of Herba Ecliptaes, 8～12 parts of Cacumen Platycladis;
Accessory drugs: fat of Oromaius norvaehollandeae; Wherein, the mass concentration of fat of Oromaius norvaehollandeae in pharmaceutical composition is 4%～6%.
In order to realize the present invention better, the weight portion proportion optimization of described principal agent:
15 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 10 parts of Semen Sesami Nigrums, 15 parts of Radix Polygoni Multiflori, 5 parts on Flos Carthami, 10 parts of Radix Paeoniae Rubra, 10 parts in Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of Cacumen Platycladis.
The mass concentration of fat of Oromaius norvaehollandeae in pharmaceutical composition preferred 5%.
Preparation of drug combination method of the present invention may further comprise the steps:
(1) boil adding 10～40 times of weight decoctings after Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Zingiberis Recens, Herba Ecliptae, the Cacumen Platycladi pulverizing, filter, it is standby to get the filtrate I;
(2) Radix Angelicae Sinensis being pulverized with volumetric concentration is 70% soak with ethanol 3～7 days, and 70% consumption of ethanol is 2～3 times of Radix Angelicae Sinensis quality, and soak is filtered, must the filtrate II standby;
(3) Semen Sesami Nigrum is smashed to pieces with the soak with ethanol of volumetric concentration 75% 3～7 days, 75% consumption of ethanol is 2～3 times of Semen Sesami Nigrum quality, soak is filtered, the filtrate III is standby;
(4) filtrate I, II and III are merged, add fat of Oromaius norvaehollandeae and volumetric concentration then and be 95% ethanol, make the quality final concentration of fat of Oromaius norvaehollandeae in the medicinal liquid reach 4%～6%, alcoholic acid quality final concentration reaches 70%～80%.
In order better to realize the present invention:
Decocting the decocting that preferably at every turn adds 30 times of quality in the described step (1) boils.
In the described step (4), alcoholic acid quality final concentration is preferably 75%.
Decoction of the present invention is the decocting method of field of Chinese medicines routine, is about to add water after the pulverizing medicinal materials, and intense fire is heated to boiling then, and boiling back slow fire boiled 10～20 minutes.
Using method during medicine composite for curing alopecia of the present invention is: dip in cotton balls and get medicine of the present invention, wiping alopecia place repeatedly, every day sooner or later each once, one month is a course of treatment.
The used Radix Rehmanniae of the present invention, the dry root that Radix Rehmanniae Preparata all derives from scrophulariaceae rehmannia glutinosa plant are the different processed goods of same medicine.Radix Rehmanniae is the dry product of bright product, and Radix Rehmanniae Preparata is the product that steam of Radix Rehmanniae.The two is the energy Yin-nourishing and body fluid promoting all, controls all diseases of Yin and fluid deficiency.The Radix Rehmanniae clearing up internal heat by using drugs of bitter in taste and cold in nature, Gan Hanzhi moistens yin nourishing, and the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, intestine moistening is arranged; Radix Rehmanniae Preparata sweet in the mouth tepor matter profit is gone into Liver and kidney two warps, the both kind YIN nourishing of enriching blood, can mend again lean with, cure mainly the cloudy disease of losing oligospermia of blood deficiency.
Radix Polygoni Multiflori is the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb., slightly warm in nature, and sweet in the mouth, puckery is returned liver, kidney channel, has enrich and benefit essence and blood, and nourishing the liver is calmed the nerves, bone and muscle strengthening, the function of the crow palpus that reinforces the kidney.
Flos Carthami: Flos Carthami (English) Safflower, another name shuteria pampaniniana, thorn Flos Carthami, Flos Carthami, golden red flower are the tubular flower of feverfew Flos Carthami CarthamustinctoriusL., have the effect of the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.
Radix Paeoniae Rubra: English red paeony root by name, the root for dicotyledon medicine ranunculaceae plant Radix Paeoniae (wild species), Paeonia obovata Maxim., river Radix Paeoniae Rubra etc. has clots absorbing, pain relieving, removing heat from blood, detumescence.
Rhizoma Zingiberis Recens is the fresh rhizome of Zingiberaceae herbaceos perennial Rhizoma Zingiberis Recens, and Rhizoma Zingiberis Recens is killed trichomonas vaginitis and suppressed the dermatophytes effect external.
Herba Ecliptae: English Herba Ecluptae by name, be the dry aerial parts of feverfew Eclipta prostrata Eclipta prostrata L., sweet in the mouth, acid, cold, return kidney, Liver Channel, have nourishing the liver and kidney, the effect of cooling blood for hemostasis.
Cacumen Platycladi: be the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco, bitter in the mouth, puckery, cold is returned lung, liver, spleen channel, has cooling blood for hemostasis, the effect of growing and blacking hair.
Fat of Oromaius norvaehollandeae: be the animal oil that extract from the Dromaius novaehollandiae that grows up on one's body, have vigor that promotes skin follicle and the effect that promotes the growth of skin and hair.Dromaius novaehollandiae (Emu, Dromaius novaehollandiae) has another name called emu, originates in Australia.Dromaius novaehollandiae height 1.5～2.0m, about height 1.5m, about body weight 35kg, foot is big, and three-toed, feather are that dull gray is brown, can not fly, but be good at walking fast.
The present invention compared with prior art has the following advantages:
(1) pharmaceutical composition of the present invention is solvent with ethanol, and ethanol is stronger lytic agent, has volatilization, and its property benefaction, and blood can relax, permeate cortex, and 75% ethanol can kill the fungus on the scalp, the function that also have detumescence, takes out stains;
(2) contain necessary aminoacid of multiple human body and trace element in the pharmaceutical composition of the present invention, can permeate cortex and directly be absorbed, strengthen the hair follicle nutrition supply, improve the nutritional status of hair, promote scalp blood circulation and drug absorption by cortical cell;
(3) also contain the hormone that promotes cell division and growth in the pharmaceutical composition of the present invention, can promote hair follicle to recover rapidly and arrector pilli muscle formation, promote the sebum metabolism, regulate organism endocrine and gonadal hormone balance, stimulate human body melanin to generate;
(4) pharmaceutical composition of the present invention can effectively activate rest cell, makes the vigor of skin follicle be able to obvious improvement, and skin thickness obviously thickens, thus the growth that can chafe and the growth of hair;
(5) pharmaceutical composition of the present invention effect highly significant in clinical experiment, one month time just can be felt the generation of new hair, just feels the hair of pricking the hand in three months.
The specific embodiment
Below enumerate some preferred embodiments of the present invention, understand the present invention to help further, but scope of the present invention is not limited thereto.
The source of used main Chinese medicinal materials is respectively in following examples:
Radix Angelicae Sinensis: the precious hall of Guangxi Yulin pharmacy group ginseng Chinese crude drug company limited;
Radix Rehmanniae, Radix Rehmanniae Preparata: treasure's Chinese herbal medicine group during Beijing;
Semen Sesami Nigrum: sesame produce company limited in the Anhui;
Radix Polygoni Multiflori, Flos Carthami: pharmaceuticals of Tujia Autonomous County of Shizhu;
Radix Paeoniae Rubra, Rhizoma Zingiberis Recens: the big pharmacy of Chongqing Tong Junge;
Herba Ecliptae, Cacumen Platycladi: Chinese crude drug wholesale market, Chongqing;
Fat of Oromaius norvaehollandeae: treasure's Chinese herbal medicine group during Beijing.
Embodiment 1 pharmaceutical composition of the present invention
Get 15 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 10 parts of Semen Sesami Nigrums, 15 parts of Radix Polygoni Multiflori, 5 parts on Flos Carthami, 10 parts of Radix Paeoniae Rubra, 10 parts in Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of Cacumen Platycladis by mass parts;
(1) boil add 30 times of weight decoctings after Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Zingiberis Recens, Herba Ecliptae, the Cacumen Platycladi pulverizing at every turn, decoct 2 times, filter, it is standby that merging filtrate gets the filtrate I;
(2) adding volumetric concentration after Radix Angelicae Sinensis is pulverized is 70% soak with ethanol 5 days, and 70% alcoholic acid addition is 2.5 times of Radix Angelicae Sinensis weight, filter, the filtrate II is standby;
(3) Semen Sesami Nigrum being smashed to pieces with volumetric concentration is that 75% ethanol (75% alcoholic acid addition is 2.5 times of Semen Sesami Nigrum weight) soaked 5 days, filter, the filtrate III is standby;
(4) filtrate I, II and III are merged, add fat of Oromaius norvaehollandeae then, add volumetric concentration again and be 95% ethanol, the quality final concentration that makes fat of Oromaius norvaehollandeae in the medicinal liquid is 5%, and alcoholic acid quality final concentration is 75% promptly to get pharmaceutical composition of the present invention.
Embodiment 2 preferred for preparation methods of the present invention
(1) get by mass parts and add 30 times of weight decoctings after 10 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 15 parts of Radix Polygoni Multiflori, 5 parts on Flos Carthami, 10 parts of Radix Paeoniae Rubra, 10 parts in Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of pulverizing of Cacumen Platycladi and boil 2 times, filter, the filtrate I is standby;
(2) with adding 70% soak with ethanol 5 days of 3 times of weight after 15 parts of pulverizing of Radix Angelicae Sinensis, filter, the filtrate II is standby;
(3) 10 parts of Semen Sesami Nigrums are smashed to pieces with 75% ethanol (consumption is 3 times of Semen Sesami Nigrum quality) immersion 5 days, soak is filtered, it is standby to get the filtrate III;
(4) filtrate I, II and III are merged, add fat of Oromaius norvaehollandeae and volumetric concentration then and be 95% ethanol, make that the final concentration of fat of Oromaius norvaehollandeae reaches 5% in the medicinal liquid, alcoholic acid final concentration reaches 75% promptly.
Embodiment 3 pharmaceutical compositions of the present invention and preparation method thereof
Get Radix Angelicae Sinensis 300 grams, Radix Rehmanniae 200 grams, Radix Rehmanniae Preparata 200 grams, Semen Sesami Nigrum 200 grams, Radix Polygoni Multiflori 300 grams, Flos Carthami 100 grams, Radix Paeoniae Rubra 200 grams, Rhizoma Zingiberis Recens 200 grams, Herba Ecliptae 100 grams, Cacumen Platycladi 200 grams;
(1) adds 30 times of weight decoctings after Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Zingiberis Recens, Herba Ecliptae, Cacumen Platycladi are pulverized at every turn boil that (first intense fire is heated to boiling, and then slow fire boiled 15 minutes), decoct 2 times, filter, it is standby that merging filtrate gets the filtrate I;
(2) Radix Angelicae Sinensis is pulverized the back and soaked 5 days with 70% ethanol (70% consumption of ethanol is 2 times of Radix Angelicae Sinensis quality), soak is filtered, it is standby to get the filtrate II;
(3) Semen Sesami Nigrum is smashed to pieces with 75% ethanol (consumption is 2 times of Semen Sesami Nigrum quality) immersion 5 days, soak is filtered, it is standby to get the filtrate III;
(4) filtrate I, II and III are merged, add fat of Oromaius norvaehollandeae and 95% ethanol then, the quality final concentration that makes fat of Oromaius norvaehollandeae in the medicinal liquid is 5%, and alcoholic acid quality final concentration is 75% promptly to get pharmaceutical composition of the present invention.
Embodiment 4 pharmaceutical compositions of the present invention and preparation method thereof
(1) gets and add each 40 times of weight decoctings after Radix Rehmanniae 160 gram, Radix Rehmanniae Preparata 160 grams, Radix Polygoni Multiflori 360 grams, Flos Carthami 120 grams, Radix Paeoniae Rubra 240 grams, Rhizoma Zingiberis Recens 240 grams, Herba Ecliptae 120 grams, Cacumen Platycladi 240 grams are pulverized and boil that (first intense fire is heated to boiling, and then slow fire boiled 20 minutes), decoct 3 times, filter, merge to such an extent that the filtrate I is standby;
(2) Radix Angelicae Sinensis 360 is restrained the pulverizing back and soaked 7 days with 70% ethanol (consumption is 3 times of Radix Angelicae Sinensis quality), soak is filtered, it is standby to get the filtrate II;
(3) Semen Sesami Nigrum 240 grams are smashed to pieces with 75% ethanol (consumption is 3 times of Semen Sesami Nigrum quality) immersion 7 days, soak is filtered, it is standby to get the filtrate III;
(4) filtrate I, II and III are merged, add fat of Oromaius norvaehollandeae and 95% ethanol then, make that the final concentration of fat of Oromaius norvaehollandeae reaches 6% in the medicinal liquid, alcoholic acid final concentration reaches 80% promptly.
Embodiment 5 pharmaceutical compositions of the present invention and preparation method thereof
(1) gets and add 10 times of weight decoctings after Radix Rehmanniae 240 gram, Radix Rehmanniae Preparata 240 grams, Radix Polygoni Multiflori 240 grams, Flos Carthami 80 grams, Radix Paeoniae Rubra 160 grams, Rhizoma Zingiberis Recens 160 grams, Herba Ecliptae 80 grams, Cacumen Platycladi 160 grams are pulverized and boil that (first intense fire is heated to boiling, and then slow fire boiled 10 minutes), filter, it is standby to get the filtrate I;
(2) Radix Angelicae Sinensis 240 is restrained the pulverizing back and soaked 3 days with 70% ethanol (consumption is 2.5 times of Radix Angelicae Sinensis quality), soak is filtered, it is standby to get the filtrate II;
(3) Semen Sesami Nigrum 160 grams are smashed to pieces with 75% ethanol (consumption is 2.5 times of Semen Sesami Nigrum quality) immersion 3 days, soak is filtered, it is standby to get the filtrate III;
(4) filtrate I, II and III are merged, add fat of Oromaius norvaehollandeae and 95% ethanol then, make that the final concentration of fat of Oromaius norvaehollandeae reaches 4% in the medicinal liquid, alcoholic acid final concentration reaches 70% promptly.
Embodiment 6 pharmaceutical compositions of the present invention and preparation method thereof
(1) get and add 20 times of weight decoctings after Radix Rehmanniae 800 gram, Radix Rehmanniae Preparata 800 grams, Radix Polygoni Multiflori 1500 grams, Flos Carthami 600 grams, Radix Paeoniae Rubra 1100 grams, Rhizoma Zingiberis Recens 900 grams, Herba Ecliptae 500 grams, Cacumen Platycladi 1200 grams are pulverized and boil 2 times, filter, the filtrate I is standby;
(2) Radix Angelicae Sinensis 1500 is restrained the pulverizing back and soaked 3 days with 70% ethanol (consumption is 3 times of Radix Angelicae Sinensis quality), soak is filtered, it is standby to get the filtrate II;
(3) 8～12 parts of Semen Sesami Nigrums are smashed to pieces with 75% ethanol (consumption is 3 times of Semen Sesami Nigrum quality) immersion 4 days, soak is filtered, it is standby to get the filtrate III;
(4) filtrate I, II and III are merged, add fat of Oromaius norvaehollandeae and 95% ethanol then, make that the final concentration of fat of Oromaius norvaehollandeae reaches 5% in the medicinal liquid, alcoholic acid final concentration reaches 75% promptly.
The application of embodiment 7 pharmaceutical compositions of the present invention
(wherein the male is 52 to 60 hair loss patients with embodiment 4 drug prepared compositionss, 8 of women, the range of age is 20～50 years old, the alopecia degree is from little bald extremely almost alopecia totalis) treat, administrated method is put the affected part on the skin for cotton swab this medicinal liquid being coated with, each once was coated with at every turn and put 0.5～5 minute on the skin sooner or later every day, and one month is a course of treatment.After medication course of treatment, 58 patients' alopecia place has tangible hair growth, and other 2 patients also have tangible hair growth in two second course of treatment, and after three courses of treatment, hands is touched patient's former alopecia place, and can feel has difficult to handle hair growth.And after the medication patient's health the affected part without any difference.Illustrate that pharmaceutical composition of the present invention is effective and be free from side effects to the treatment of alopecia.
Claims (5)
1. a pharmaceutical composition for the treatment of alopecia is characterized in that, is made by following medicinal materials in part by weight raw material:
Principal agent: 12～18 parts of Radix Angelicae Sinensis, 8～12 parts of Radix Rehmanniae, 8～12 parts of Radix Rehmanniae Preparata, 8～12 parts of Semen Sesami Nigrums, 12～18 parts of Radix Polygoni Multiflori, 4～6 parts on Flos Carthami, 8～12 parts of Radix Paeoniae Rubra, 8～12 parts in Rhizoma Zingiberis Recens, 4～6 parts of Herba Ecliptaes, 8～12 parts of Cacumen Platycladis;
Accessory drugs: fat of Oromaius norvaehollandeae; Wherein, the mass concentration of fat of Oromaius norvaehollandeae in pharmaceutical composition is 4%～6%.
2. a kind of pharmaceutical composition for the treatment of alopecia according to claim 1 is characterized in that, the weight portion proportioning of described principal agent is:
15 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 10 parts of Semen Sesami Nigrums, 15 parts of Radix Polygoni Multiflori, 5 parts on Flos Carthami, 10 parts of Radix Paeoniae Rubra, 10 parts in Rhizoma Zingiberis Recens, 5 parts of Herba Ecliptaes, 10 parts of Cacumen Platycladis.
3. a kind of pharmaceutical composition for the treatment of alopecia according to claim 1 is characterized in that the mass concentration of described fat of Oromaius norvaehollandeae in pharmaceutical composition is 5%.
4. the preparation of drug combination method of the described treatment alopecia of claim 1 may further comprise the steps:
(1) by weight, get 12～18 parts of Radix Angelicae Sinensis, 8～12 parts of Radix Rehmanniae, 8～12 parts of Radix Rehmanniae Preparata, 8～12 parts of Semen Sesami Nigrums, 12～18 parts of Radix Polygoni Multiflori, 4～6 parts on Flos Carthami, 8～12 parts of Radix Paeoniae Rubra, 8～12 parts in Rhizoma Zingiberis Recens, 4～6 parts of Herba Ecliptaes, 8～12 parts of Cacumen Platycladis;
Boil adding 10～40 times of weight decoctings after Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Zingiberis Recens, Herba Ecliptae, the Cacumen Platycladi pulverizing, filter, it is standby to get the filtrate I;
(2) Radix Angelicae Sinensis being pulverized with volumetric concentration is 70% soak with ethanol 3～7 days, and 70% consumption of ethanol is 2～3 times of Radix Angelicae Sinensis quality, and soak is filtered, must the filtrate II standby;
(3) Semen Sesami Nigrum is smashed to pieces with the soak with ethanol of volumetric concentration 75% 3～7 days, 75% consumption of ethanol is 2～3 times of Semen Sesami Nigrum quality, soak is filtered, the filtrate III is standby;
(4) filtrate I, II and III are merged, add fat of Oromaius norvaehollandeae and volumetric concentration then and be 95% ethanol, make the quality final concentration of fat of Oromaius norvaehollandeae in the medicinal liquid reach 4%～6%, alcoholic acid quality final concentration reaches 70%～80% promptly.
5. preparation method according to claim 4 is characterized in that, adds the water of 30 times of weight when decocting in the described step (1).
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| 刘爱民,陈达灿,胡东流.综合疗法治疗斑秃研究态势评析.中医药学刊21 10.2003,21(10),1769-1771. * |
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