CN104013947A - Hair-restorer spraying liquid of fresh medicine, fruit and vegetable ferments with effects of preventing hair loss and restoring hair and preparation method thereof - Google Patents
Hair-restorer spraying liquid of fresh medicine, fruit and vegetable ferments with effects of preventing hair loss and restoring hair and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a hair-restorer spraying liquid of fresh medicine, fruit and vegetable ferments with effects of preventing hair loss and restoring hair. The hair-restorer spraying liquid is prepared from the following raw materials in parts by weight: 3-5 parts of fresh traditional Chinese medicinal materials, 7-10 parts of fresh fruits and vegetables, 1 part of brown sugar and 8-12 parts of purified water in a fermentation manner. Fresh traditional Chinese medicinal materials and fresh fruits and vegetables are taken as raw materials, and not heated in the overall production process, no chemical component is added, biological ferments are prepared by completely utilizing biological enzymes of the fresh traditional Chinese medicinal materials and the fresh fruits and vegetables and beneficial bacteria in a natural fermentation manner, and the effective components of the medicinal materials and the fruits and vegetables are fully released, so that the content of the effective components of the traditional Chinese medicinal materials, vitamins and microelements in the product is greatly improved. The hair-restorer spraying liquid is used by 58 cases of hair-loss patients, and the effective rate can be up to 89.9%.
Description
Technical field
The present invention relates to a kind of hair growth promoting external preparation, be specifically related to a kind of fresh medicine fruit-vegerable ferment hair growth promoting spray coating liquor with Anti-hair loss and hair regrowth and preparation method thereof.
Background technology
Alopecia is a kind of common dermatosis, and bald appearance and the psychology to people causing because of alopecia causes great injury.Cause the reason of alopecia a lot, existing congenital or genetic factor, also has factor posteriority; Existing physiological reason, also has pathologic reason.Alopecia is at present divided into two types substantially: the permanent alopecia causing because hair follicle is impaired is common male's temporary alopecia bald and that cause because the hair follicle short time is impaired.The current medical circle of the cause of disease of alopecia there is no unified suggestion, and doctor trained in Western medicine is thought mostly may be relevant with following factor: as acute and chronic infectious disease, endocrine disturbance, stress, various dermatosis, inherited genetic factors, do not have enough sleep, chronic poisoning, trophic factor (comprise electrolytes and minerals lacks, high fat food intake too much), environment and chemical factors etc.These factors cause that scalp nutrition supply is unbalance, poor blood circulation, oils and fats too much cause hair follicle cannot obtain enough nutrition, cause hair follicle hair can not be fixed, and finally cause alopecia.
Chinese medicine thinks that alopecia has two kinds of reasons: the one, heat in blood wind-dryness, heat in blood wins partially, consumption impairment of YIN blood, the raw wind of blood tiger, more impairment of YIN blood, cloudy blood can not on cause top, mountain peak and moisten foster Rhizoma Imperatae, Rhizoma Imperatae is dry, or apprehensive coming off; The 2nd, damp-heat in the spleen and stomach, insufficiency of the spleen transporting is unable, addiction to greasy and sweet foods savoury in addition, the damage that injures one's stomach spleen, causes top, damp and hot upper steaming mountain peak, corrodes root of hair, and root of hair is gradually corroded, and hair shows sticky and comes off.
The means of hair growth are a lot of at present, mainly contain chemotherapy, Chinese herbal treatment and surgical operation therapy etc.Chemotherapy is oral finasteride, external minoxidil etc. such as.Operative treatment is evenly to plant in alopecia position after the healthy hair follicle of self rear pillow part being separated, cultivated by the method for operation, makes it grow new hair.But there is the shortcomings such as side effect is larger or need special and professional care in these treatment meanss, the defects such as operation inconvenience.
The inventor retrieves Chinese medicine for nearly hundred sections, the patent of anticreep and hair growth promoting and document, make extractum as patent CN102885994A " suppress seborrheic alopecia Chinese medicine composition and preparation method thereof " adopts the nine taste Chinese medicines heating such as the Radix Polygoni Multiflori, Cacumen Platycladi, Rhizoma Zingiberis Recens, then and then make shampoo for maintaining scalp and preventing alopecia; Patent CN103157079A " plant of anti-loss promotion hair growth promoting is embathed liquid and preparation using method thereof " adopts the eight taste Chinese medicines such as Cacumen Platycladi, Radix Mori, Sucus Zingberis to boil, and makes to embathe liquid and embrocate hair scalp for anti-loss and promote hair growth promoting; It is alcohol-pickled that patent CN101711731A " a kind of preventing hair loss and promoting hair regeneration Chinese medicine for outer use " adopts the Chinese medicine of the five flavours such as Radix Polygoni Multiflori, Folium Mori, Flos Carthami to add, and makes preparation and embrocate alopecia scalp, for pre-Anti-hair loss and promotion hair growth promoting; Patent CN102335282B " a kind of medicine of hair growth " adopts the 17 taste Chinese medicines such as Radix Scrophulariae, Flos Chrysanthemi, Fructus Lycii, Fructus Schisandrae Chinensis, decocts and makes decoction, rinses affected part, for additional issue.
Disclosed technical scheme respectively has feature above, but have following some be identical: the one, selected raw material is all prepared slices of Chinese crude drugs; The 2nd, after preparation method is nearly all water or alcohol extraction, or directly spreads upon on scalp or add a lot of chemical matrix to make shampoo; The 3rd, in prescription, be mainly that Chinese medicine extract is as active component.As everyone knows, the prepared slices of Chinese crude drugs are in the process of preparing Chinese medicine or dry run, and its loss of effective components is larger, and some active component even completely loses.Again in preparation process through heating decocting in water or alcohol extraction, further aggravated again the loss of effective ingredient.At present existing much about the Research Literatures of fresh medicine and the contrast of dry decoction pieces effective ingredient, checking without exception this point.In addition, as previously mentioned, the cause of disease of alopecia is likely that electrolytes and minerals shortage institute causes, and its electrolytes and minerals has remained little in the extracting solution of the prepared slices of Chinese crude drugs after decocting in water or alcohol extraction, as add some ethanol or other chemical compositions are made shampoo, make very fragile scalp root of hair hair follicle can't bear the heavy load.In the shampoo of certain brand of several years ago even passing on a message, carcinogen detected.Can say to so far also not yet have one to make the well-content phalacrosis prevention and hair generation product of alopecia person come out.Through retrieval, do not find that adopting fresh medicine and fruit and vegerable to prepare together the anti-loss technology contents identical with hair growth promoting enzyme liquid with the present invention openly reports.
Summary of the invention
Object of the present invention is exactly that the problem such as chemical composition is in the majority, provides a kind of fresh medicine fruit-vegerable ferment hair growth promoting spray coating liquor with Anti-hair loss and hair regrowth and preparation method thereof in order to solve active component deficiency in existing phalacrosis prevention and hair generation product; The present invention is all taking fresh Chinese crude drug and fresh fruit of vegetables as raw material, whole production process does not heat, do not add any chemical composition, utilize enzyme and probiotics natural fermentation in fresh Chinese crude drug and fresh fruit of vegetables to make biologic enzyme completely, the effective ingredient of medical material and fruit and vegerable is fully discharged, greatly improved the content of Effective Component of Chinese Medicine and vitamin in product, trace element.The present invention uses through 58 routine hair loss patients, and effective percentage reaches 89.9%.
The fresh medicine fruit-vegerable ferment spray coating liquor with Anti-hair loss and hair regrowth of the present invention, is made up of the raw material of following weight parts:
Fresh Chinese crude drug 3-5 fresh fruit of vegetables 7-10
Brown sugar 1 pure water 8-12
Described fresh Chinese crude drug is made up of 2%-3% Cordyceps, 10%-30% Radix Polygoni Multiflori, 10%-30% Folium Pini, 10%-20% Rhizoma Zingiberis Recens, the 5%-20% Radix Astragali, 10%-20% Herba Ecliptae, 10%-20% Fructus Gleditsia and 10%-20% Fructus Mori by mass fraction, and the mass fraction sum of above-mentioned each Chinese medicine used is 100%;
In described fresh fruit of vegetables, the ratio of fruits and vegetables is 1: 1～3;
When preparation, respectively fresh Chinese crude drug, fresh fruit of vegetables are cleaned up, chop up, then get brown sugar, pure water adds in jar fermenter by proportioning, at 15-30 DEG C of bottom fermentation 3-6 month, opens air bleeding valve aerofluxus between yeast phase every 7-10 days; Ferment after one month, got fermentation liquid every 10-15 days and detect its pH value and total sugar content; When pH value is 3.0～3.5, total sugar content, between 0.8-1.5%, while being clarification light brown liquid, can finish fermentation after fermentation liquid is filtered with double gauze; Fermentation liquid coarse filtration is removed to residue, then filter with the flame filter press that 500 order filter clothes are housed, filtrate again via hole diameter is the purpose ceramic-film filter filtration of 1.4 μ m, collects filtrate; Finally gained filtrate is completed to fill in the toilet of 100,000 grades, to obtain final product; Pipeline, storage tank and the filter plant that filtrate after coarse filtration contacts all needs through 120 DEG C of steam sterilization 20-25 minute.
Described fresh fruit of vegetables is to select this season fruits and vegetables as best.
The preparation method of the above-mentioned fresh medicine ferment spray coating liquor with Anti-hair loss and hair regrowth, comprises the steps:
(1) pre-treatment
Get fresh Cordyceps, Radix Polygoni Multiflori, Rhizoma Zingiberis Recens, the Radix Astragali, Herba Ecliptae, Fructus Gleditsia, Fructus Mori, Folium Pini and fruit and vegetable, will wherein rot and impurity part is sorted out, clean with clear water; Be cut into small pieces respectively or strip by its shape facility, for subsequent use;
(2) mixed culture fermentation
Get respectively processed good fresh Chinese crude drug, fruit and vegetable and brown sugar, pure water by proportioning, be placed in jar fermenter, at 15-30 DEG C of bottom fermentation 3-6 month; Between yeast phase, opened air bleeding valve aerofluxus every 7-10 days; Ferment after one month, got fermentation liquid every 10-15 days and detect its pH value and total sugar content; When pH value is 3.0～3.5, total sugar content, between 0.8-1.5%, while being clarification light brown liquid, can finish fermentation after fermentation liquid is filtered with double gauze;
(3) fermentation liquor treatment
Fermentation liquid is removed to residue with double gauze coarse filtration, then filter with the filter that 500 order gauzes are housed, filtrate again via hole diameter is the purpose ceramic-film filter filtration of 1.4 μ m, obtains filtrate;
(4) fill
By filtrate fill in 100,000 grades of toilets, to obtain final product; Pipeline, storage tank and the filter plant that filtrate after coarse filtration contacts all needs through 120 DEG C of steam sterilization 20-25 minute.
1.4 μ m ceramic membranes used are that France produces.
The Cordyceps using in the present invention, Latin formal name used at school: Cordyceps, for colonizing in Stroma and the larva cadaveric complex on Hepialidae insect larvae, its nature and flavor are sweet, temperature, function invigorating the lung and the kidney, preventing phlegm from forming and stopping coughing, can be used for chronic cough dyspnea due to deficiency, the disease that puerperal asthenia, sexual impotence are sombre etc. " void ".Modern pharmacology research shows, contains cordycepic acid approximately 7% in Cordyceps, saccharide 28.9%, and fat approximately 8.4%, protein approximately 25%, in fat, 82.2% is unsaturated fatty acid, in addition, still contains vitamin B12, Ergota lipidol, hexose alcohol, alkaloid etc.Research shows, cordycepin in Cordyceps can suppress the growth of the pathogenic bacteria such as streptococcus, Actinobacillus mallei anthrax bacillus, it is again anticancer active substance, the regulating action that hormonal system to human body and nervous system have had, can change microcirculation in human body, there is obvious blood fat reducing and Antitussive and Expectorant Effect; A kind of immunomodulator, can enhancing body to virus and parasitic resistance.Cordyceps is annual to be excavated around the Summer Solstice, after having dug, in the time that polypide humidity is not dry, removes outer earth, puts-10 DEG C of following stored frozen fresh-keeping.
Radix Polygoni Multiflori used in the present invention, Latin formal name used at school: Radix Polygoni Multiflori is few section perennial winding liana, Radix Polygoni Multiflori belongs to.Slightly warm in nature, bitter in the mouth, sweet, puckery, has effect of enrich and benefit essence and blood, black beard and hair, bone and muscle strengthening, invigorating the liver and kidney.Modern pharmacology research shows, the material base of Radix Polygoni Multiflori efficacy effect is mainly the compositions such as phospholipid, Anthraquinones, glucose glycoside; Can promote human body hemopoietic function, improve body's immunity, blood fat reducing, atherosclerosis, protects the liver, and slow down aging affects endocrine function, loosening bowel to relieve constipation etc.; It is the key medicine of conventional hair color black hair.
Radix Polygoni Multiflori is excavated spring and autumn, after having dug, removes outer earth, puts-10 DEG C of following stored frozen fresh-keeping.
The Radix Astragali used in the present invention, Latin formal name used at school: Leguminosae, is pulse family, Papillionoideae.Sweet in the mouth, tepor.There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency and yellow complexion, interior-heat is quenched one's thirst etc.Modern pharmacology research shows, the Radix Astragali contains sucrose, glucuronic acid, astragalus polysaccharides A, B, C, D, lymphatic temperament, the various trace elements such as several amino acids, bitter principle, Radix Astragali saponin, betanin, choline, folic acid (65 microgram/100 gram dry root), flavane compound and selenium, silicon, zinc, cobalt, copper, molybdenum.
The Radix Astragali is excavated autumn, after having dug, removes outer earth, puts-10 DEG C of following stored frozen fresh-keeping.
Fructus Gleditsia used in the present invention, is also Fructus Gleditsia, Fructus Gleditsia, large Fructus Gleditsia, long Fructus Gleditsia, outstanding cutter, long Fructus Gleditsia, Chinese honey locust (fruit), black rhinoceros.It is the natural material of medicine food, health product, cosmetics and articles for washing; There is the effect of anticreep black hair.According to the literature, the medicine that contains saponin composition, can clearing away heat and eliminating dampness, dispel superabundant fats, unobstructed obstruction hair follicle, rather good to Anti-hair loss and black hair effect, and can scalp irritation.In addition, also have eliminate the phlegm, antibacterial action; Fructus Gleditsia all has inhibitory action to Grain-negative enteral pathogenic bacterium such as escherichia coli, bacterium sonnei, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera.Fructus Gleditsia water logging agent (1:3), all has inhibitory action in various degree to the dermatophytes such as trichophyton, star-shaped nocardia in vitro.
Fructus Gleditsia is plucked when fruit maturation in annual autumn, selects plumpness, that full, the hard person of matter puts-10 DEG C of following stored frozen is fresh-keeping.
The Rhizoma Zingiberis Recens using in the present invention, Latin formal name used at school: Zingiber officinale Roscoe, for Zingiberaceae, Rhizoma Zingiberis Recens belong to.Warm in nature, acrid in the mouth.Its effective ingredient is the mixture of zingiberone and ginger ketenes.Breathing and vasomotor center are had to excitation, can blood circulation promoting.Experiment in vitro, has obvious inhibitory action to Bacillus typhi, vibrio cholera.Folk remedy is recorded, and with hot Jiang Shui cleaning hair, can effectively prevent and treat the dandruff and drop.In addition,, through conventional hot Jiang Shui hair washing, bald head is also had to certain therapeutic effect.The traditional Chinese medical science thinks, Rhizoma Zingiberis Recens is supporing yang product, has the effects such as the human body of quickening metabolism, the meridian dredging.With Rhizoma Zingiberis Recens concentrated extract or directly smear hair with Rhizoma Zingiberis Recens; gingerol wherein, zingiberene wet goods composition; can make skin of head blood circulation normalization; promote scalp metabolism; activation hair follicle tissue, anti-loss, poliosis effectively, stimulates new growth; and can suppress scalp pruritus, strengthening root of hair.From theory of Chinese medical science, Rhizoma Zingiberis Recens is warm in nature, has and induces sweat, the effect of dispersing, so external Rhizoma Zingiberis Recens can increase local blood circulation really, hair follicle stimulating is opened, and impels hair regeneration.Rhizoma Zingiberis Recens is removed stem and leaf and fibrous root after excavating summer, is placed in yellow sand cellar for storing things fresh-keeping storage.
The Herba Ecliptae using in the present invention, another name: Nanjing grass, Alternanthera sessilis (L.) DC., Herba Ecliptae, yerbadetajo seed, white Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae), Herba Ecliptae etc., sweet in the mouth acid, cool in nature, enter Liver and kidney two warps.There is liver and kidney tonifying, effect of cooling blood for hemostasis.Cure mainly: deficiency of the liver and kindey, to have a dizzy spell, early whitening of beard and hair, spits blood, spitting of blood, traumatic hemorrhage etc.
Herba Ecliptae extracts herb summer and autumn, eliminates silt, and bundling postposition-10 DEG C following stored frozen is fresh-keeping.
Fructus Mori used in the present invention, the mature fruit of deciduous tree mulberry, Latin formal name used at school: Fructus Mori.Nature and flavor are sweet, sour, cold in nature.Main effect nourishes blood, promotes the production of body fluid, hair growth promoting, anti-early whitening of beard and hair.In Fructus Mori, contain several functions composition, as rutin, anthocyanidin, resveratrol etc., there is the effects such as good anti-cancer, defying age, antiulcer, antiviral.Fructus Mori are improved skin (comprising scalp) blood supply, and nutrition skin makes the effects such as the delicate and black hair of skin, and can slow down aging.Ancients are with Folium Mori hair care.With Folium Mori Folium Cannabis boil water from washing rice wash one's hair send out can impel natural on-off cycles of hair growth.Modern pharmacological research finds, the fatty acid in Fructus Mori has and reduces fat, prevents the effects such as sclerosis of blood vessels; Contain black and glossy that black hair element can make that hair becomes, can improve skin and comprise that scalp blood supply nutrition skin makes effects such as the delicate and black hair of skin can slow down aging.
The annual 5-6 month of Fructus Mori plucks while being reddish violet, is placed in-10 DEG C of following stored frozen fresh-keeping.
The Folium Pini using in the present invention is the needle of the Folium seu Strobilus Pini sibiricae in Pinaceae pine genus plant, Pollen pini thunbergii, Pinus etc.Bitter, puckery, temperature.In Chinese medicine ancient books and records, record it and there is expelling wind and activating blood circulation, removing toxic substances, effect of antipruritic, hair growth promoting.Cure mainly: rheumatism flaccidity syndrome and arthralgia syndrome; Foot gas; Eczema; Tinea; Rubella pruritus; Traumatic injury; Neurasthenia; Chronic nephritis; Hypertension.Preventing encephalitis, influenza.Modern pharmacology research shows, extract from pine needles is rich in saccharide, crude protein, crude fat, several amino acids and lot of trace ore deposit element, multivitamin, bioflavonoid material, quintessence oil, chlorophyll, unsaturated fatty acid, enzyme and coenzyme isoreactivity material.Test discovery by modern technologies: the Folium Pini root of hair element that Folium Pini contains high concentration is the extremely strong bioprotein of a kind of bioadhesive, 360 degree helical molecular structures of its uniqueness, root of hair can be stabilized in hair follicle firmly, be described as botanic " hair growth promoting gold ".
Folium Pini can be adopted the whole year, raw material abundance, ready access upon use.
The fruit and vegerable that use in the present invention are taking the fruit and vegetable of this season output as best, and four seasons fruit comprises Fructus Pruni pseudocerasi, Folium Eriobotryae, Fructus Citri Limoniae, Fructus Fragariae Ananssae, Fructus Lycopersici esculenti, Fructus Persicae, Fructus Pruni salicinae, Citrullus vulgaris, Fructus Melo, Fructus Ananadis comosi, Arillus Longan, Fructus Litchi, Fructus Musae, Fructus Mali pumilae, pears, hami melon, Fructus actinidiae chinensis, Fructus Vitis viniferae, Punica granatum L., Fructus Mangifera Indicae, fresh Fructus Jujubae, Fructus Citri junoris, Fructus Crataegi, Fructus Citri tangerinae, Fructus Citri grandis etc.; The four seasons, vegetable comprised: Herba Spinaciae, Caulis Zizaniae caduciflorae, Caulis et Folium Chrysanthemi segeti, tender flower stalk, water spinach, Caulis et Folium Lactucae sativae, Herba Astragali Sinici, Caulis et Folium Brassicae junceae, Herba Apii graveolentis, spring bamboo, Plantula Brassicae chinensis, Fructus Solani melongenae, Fructus Cucumidis sativi, fresh kidney beans, Fructus Luffae, Fructus Momordicae charantiae, Fructus Benincasae, Fructus Cucurbitae moschatae, Rhizoma Solani tuber osi, white turnip, Radix Dauci Sativae, Chinese cabbage, Rhizoma Nelumbinis, Brassica oleracea L.var.capitata L. etc.
The Chinese medicine for Anti-hair loss, black hair, hair growth promoting, hair care effect of recording in all kinds of disclosed documents at present reaches tens kinds, and its effect of different prescriptions is inevitable different.The present invention selects Radix Polygoni Multiflori, Herba Ecliptae, Fructus Gleditsia, Fructus Mori, Rhizoma Zingiberis Recens, Folium Pini, the Radix Astragali and Cordyceps by monarch compatibility from conventional Chinese medicine, wherein Radix Polygoni Multiflori enriching yin and nourishing kidney, and hair color is made light of one's life by commiting suicide; Folium Pini nourishing kidney hair growth promoting, the Folium Pini root of hair element that wherein contains high concentration is the extremely strong bioprotein of a kind of bioadhesive, 360 degree helical molecular structures of its uniqueness, can be stabilized in root of hair in hair follicle firmly, are described as botanic " hair growth promoting gold ".Herba Ecliptae, Fructus Mori, kidney-supplementing liver-boosting, let out blood hemostasis, controls early whitening of beard and hair; Fatty acid in Fructus Mori has and reduces fat, prevents the effects such as sclerosis of blood vessels; It is black and glossy that the black hair element containing can make that hair becomes, and has the skin of improvement and comprise that scalp blood supply nutrition skin makes effects such as the delicate and black hair of skin can slow down aging.Fructus Gleditsia, Rhizoma Zingiberis Recens are product warm in nature, energy damp eliminating, and fat melting is antibacterial, induces sweat and disperses, and increases local blood circulation, and hair follicle stimulating is opened, and promotes hair regeneration; Radix Astragali energy invigorating QI to consolidate the body surface resistance, expelling pus and promoting granulation; And the fresh Cordyceps of special use in the present invention, generally as oral formulations raw material; Modern pharmacological research shows, in the worm summer, containing having an appointment 7% cordycepic acid, has another name called mannitol, and molecular formula is C
7h
12o
6, be Cordyceps main active, can suppress the growth of various pathogenic bacterias, can prevent and treat cerebral thrombosis, cerebral hemorrhage, anti-tissue fibering, anti peroxidation of lipid; In the worm summer, also contain adenosine, there is effect of improving microcirculation and regional blood flow.It is better than not adding the result of use of spray coating liquor of Cordyceps to experiment showed, the spray coating liquor result of use that adds after Cordyceps.
These several fresh medicines that use in the present invention almost all can be plucked (digging) summer and autumn.Unsuitable freezing except Rhizoma Zingiberis Recens, must be placed in yellow sand cellar for storing things bury fresh-keeping outside, all the other all can be below-10 DEG C refrigerated storage fresh-keeping, kept to greatest extent its active component do not run off or destroy.And the fresh fruit of vegetables using in the present invention, raw material is very abundant, and this season fruit and vegerable are without cold preservation, and can have fresh feed supply every day.Use fresh Chinese crude drug together with fresh fruit of vegetables, do not adding under any exogenous zymogenic condition, utilizing the probiotics (enzyme) of fresh Chinese crude drug and fresh fruit of vegetables self to ferment, in made fresh medicine fruit-vegerable ferment, do not add any chemical composition, is real green product.And contained abundant vitamin in fresh fruit of vegetables, trace element and various in fresh Chinese crude drug have together with the active component of hair growth promoting, black hair, hair care function and nutrient substance brings out the best in each other, can supply with the abundant nutrient substance of scalp, can reduce fat again, bacteriostasis and sterilization, improves scalp blood circulation, activation hair follicle tissue, stimulate new growth, strengthen root of hair, thereby reach the object of anti-loss and hair growth promoting.
The main innovation of the present invention is, one uses fresh Chinese crude drug as primary raw material
A. fresh Chinese crude drug abnormal smells from the patient is all deposited, effective ingredient kind and content are many, as alkaloids, organic acid, volatile oil, glycoside, flavonoid, the rare class of terpene and vitamin, mineral, aminoacid etc., the destruction of the unfavorable factors such as medicine is not subject to oxidation, decomposition when fresh, lost, enzyme becomes, damages by worms, thereby fresh Chinese crude drug effectively preserved active ingredient, contain more original active component; B. fresh active ingredients from traditional Chinese medicinal stripping is more abundant.Conventional dry product Chinese medicine is in drying process, and effective ingredient is except scattering and disappearing along with the evaporation of moisture, and remainder is set in the fiber and cell wall of medical material because becoming dry.In the time decocting, again soak also and cannot fully restore.Thereby decoct compared with decoction after dry product herbal medicine immersion at fresh Chinese crude drug, fried liquid active ingredient differs widely, and active ingredient is wherein fried more than dry product medicine, and its effective ingredient is more easily fried, and drug level is higher, so effect obviously strengthens.In addition decocting, the present invention's high temperature all avoids using.
Its two, use fermentation technique extract active ingredients from traditional Chinese medicinal
Fresh Chinese crude drug juice is abundant, abnormal smells from the patient is dense, volatile component content is high, the present invention utilizes the effect of enzyme in microorganism, various active component in fresh Chinese crude drug are separated efficiently from the plant cell of fresh medical material, and enter into fermentation liquid, make these enzyme liquids there is the active substance of high concentration.Utilize the biocatalytic Activity of enzyme, decompose fresh medical material the carbohydrate such as starch, lignin, cellulose, protein, destroy the cellularity of medical material, its active component is discharged completely from cell, more easily absorbed by people's skin.In these Chinese medicine enzyme liquids, there is a large amount of enzyme simultaneously, these enzymes comprise protease, lipase, saccharifying enzyme etc., wherein lipase important role in hair growth, it can effectively promote the lipoid material that stops up hair follicle to decompose, and has the effect of clean hair follicle.Fresh Chinese crude drug fermentation liquid is more suitable for external, acts on rapider.
Its three, in fermentation raw material, also adopted fresh fruit of vegetables
In fermentation raw material, adopt fresh fruit of vegetables, in these fruit and vegerable, contain a large amount of vitamin, glucide, mineral, aminoacid and various organized enzyme, first microorganism can utilize the nutrient substance in these fruit and vegerable to carry out the Growth and reproduction of self in the time of fermentation, further decompose and utilize fresh Chinese crude drug again, the effective ingredient in medical material is fully separated.Fresh Chinese crude drug is more suitable for adopting fermentation technology conversely speaking.
Detailed description of the invention
Embodiment 1
Get 0.6 kilogram of Cordyceps, in fresh Chinese crude drug, accounting is 2%; 4.5 kilograms of Radix Polygoni Multiflori, in fresh Chinese crude drug, accounting is 15%; 3 kilograms of the Radixs Astragali, in fresh Chinese crude drug, accounting is 10%; 3 kilograms of Fructus Gleditsia, in fresh Chinese crude drug, accounting is 10%; 3 kilograms, Rhizoma Zingiberis Recens, in fresh Chinese crude drug, accounting is 10%; 3 kilograms of Herba Ecliptaes, in fresh Chinese crude drug, accounting is 10%; 6 kilograms of Fructus Mori, in fresh Chinese crude drug, accounting is 20%; 6.9 kilograms, Folium Pini, in fresh Chinese crude drug, accounting is 23%, amounts to 30kg.
Fresh fruit of vegetables adopts the fruit and vegerable of this season in summer, Citrullus vulgaris, Fructus Lycopersici esculenti, Fructus Melo, Fructus Pruni pseudocerasi, Amaranthus mangostanus L., Fructus Cucumidis sativi, Fructus Luffae, Fructus Solani melongenae, Semen vignae sinensis, and total amount is 90 kilograms.Fruit: vegetable=1:2, wherein 30 kilograms of fruit total amounts, 60 kilograms of vegetable total amounts.
10 kilograms, brown sugar.
100 kilograms of purified water.
The cleaning of raw material
Cordyceps, Fructus Mori are put into respectively to stainless steel trough manual cleaning, Radix Polygoni Multiflori, Rhizoma Zingiberis Recens and melon and fruit class are put into respectively to roller brush cleaning machine cleans, the Radix Astragali, Fructus Gleditsia, Herba Ecliptae, Folium Pini, leaf vegetables are put into respectively to vegetable washer to be cleaned, to rot part and impurity choose, and drain well, be cut into small pieces respectively or strip by its shape facility, for subsequent use;
Dress cylinder:
Adopting volume is the rustless steel jar fermenter of 500 liters, the raw material of handling well is added in jar fermenter by material proportion amount above, and adds brown sugar in proportion, finally adds purified water.Having prepared burden stirs evenly the material in cylinder afterwards with stainless steel ware, finally jar fermenter cylinder cap is built to rear sealing.
Fermentation:
Raw material in jar fermenter does not adopt pure strain inoculation technique, but utilize the microorganism of fresh Chinese crude drug, fruit and vegerable, brown sugar self to carry out fermentation culture, Summer Indoor temperature, between 25-30 DEG C, was opened aerofluxus every 7 days by air bleeding valve during fermentation culture, removal jar fermenter internal pressure.When fermentation, do not ventilate and fermentation liquid pH regulation and control, sampled by sample cock every 10 days, measure pH value and the total sugar amount of fermentation liquid, pH value should be between 3.0-6.5, and total sugar is between 0.8-1.5%.When fermentation liquid pH is determined at 3.5-4.0 continuous 3 times,, when total sugar is 1.0-1.5%, and fermentation liquid samples with clarifying after two-layer filtered through gauze, can judge and ferment.Fermentation time is 90 days.
Separation of fermentative broth, filtration:
Extract fermentation liquid out from jar fermenter middle part, through the duplex strainer of 100 order rustless steel drainage screens is housed, remove fermentation residue.Through the flame filter press of 500 order 3927# filter clothes is housed, collect filtrate again.Purpose ceramic-film filter by the filtrate of collecting through 1.4um, collects filtrate.Later pipeline, storage tank and the ceramic membrane equipment of flame filter press all needs through 120 DEG C of steam sterilizations more than 20 minutes.
Fill:
By the filtrate after ceramic membrane filter, use filling machine fill to the vial 500ml vial of sterilizing.This process need complete the toilet more than 100,000 grades, and relevant fill pipeline and equipment, Packaging Bottle need be passed through sterilization treatment.
Embodiment 2
Get 1 kilogram of Cordyceps, in fresh Chinese crude drug, accounting is 2%; 12.5 kilograms of Radix Polygoni Multiflori, in fresh Chinese crude drug, accounting is 25%; 3.75 kilograms of the Radixs Astragali, in fresh Chinese crude drug, accounting is 7.5%; 3.75 kilograms of Fructus Gleditsia, in fresh Chinese crude drug, accounting is 7.5%; 3.75 kilograms, Rhizoma Zingiberis Recens, in fresh Chinese crude drug, accounting is 7.5%; 3.75 kilograms of Herba Ecliptaes, in fresh Chinese crude drug, accounting is 7.5%; 11.5 kilograms of Fructus Mori, in fresh Chinese crude drug, accounting is 23%; 10 kilograms, Folium Pini, in fresh Chinese crude drug, accounting is 20%, amounts to 50kg.
Adopt the fresh fruit of vegetables of this season in winter, fresh Fructus Jujubae, Fructus Citri junoris, Fructus Crataegi, Fructus Citri tangerinae, Fructus Citri grandis, Chinese cabbage, Rhizoma Nelumbinis, Brassica oleracea L.var.capitata L. etc., total amount is 100 kilograms.Fruit: vegetable=1:1, so each 50 kilograms of fruits and vegetables.
10 kilograms, brown sugar;
800 kilograms of purified water;
The cleaning of raw material
Cordyceps, Fructus Mori are put into respectively to stainless steel trough manual cleaning, Radix Polygoni Multiflori, Rhizoma Zingiberis Recens and melon and fruit class are put into respectively to roller brush cleaning machine cleans, the Radix Astragali, Fructus Gleditsia, Herba Ecliptae, Folium Pini, leaf vegetables are put into respectively to vegetable washer to be cleaned, to rot part and impurity choose, and drain well, be cut into small pieces respectively or strip by its shape facility, for subsequent use;
Dress cylinder:
Adopt the rustless steel jar fermenter of 1500 liters of volumes, the raw material of handling well is added in jar fermenter by material proportion amount above, and adds brown sugar in proportion, finally add purified water.Also can utilize remaining microorganism in embodiment 1 jar fermenter to do strain.Having prepared burden stirs evenly the material in cylinder afterwards with stainless steel ware, finally jar fermenter cylinder cap is built to rear sealing.
Fermentation:
Raw material in jar fermenter does not adopt pure strain inoculation technique, but utilizes the microorganism of fresh Chinese crude drug, fruit and vegerable, brown sugar self to carry out fermentation culture, winter indoor temperature between 15-20 DEG C, if lower than this temperature, suitably heat.During fermentation culture, every 10 days, air bleeding valve is opened to aerofluxus, removal jar fermenter internal pressure.When fermentation, do not ventilate and fermentation liquid pH regulation and control, sampled by sample cock every 15 days, measure pH value and the total sugar amount of fermentation liquid, pH value should be between 3.0-6.5, and total sugar is between 0.8-1.5%.When fermentation liquid pH is determined at 3.5-4.0 continuous 3 times,, total sugar is between 0.9-1.4% time, and fermentation liquid samples with clarifying after two-layer filtered through gauze, can judge and ferment.Fermentation time is 180 days.
Separation of fermentative broth, filtration:
Extract fermentation liquid out from jar fermenter middle part, through the duplex strainer of 100 order rustless steel drainage screens is housed, remove fermentation residue.Through the flame filter press of 500 order 3927# filter clothes is housed, collect filtrate again.Purpose ceramic-film filter by the filtrate of collecting through 1.4um, collects filtrate.Later pipeline, storage tank and the ceramic membrane equipment of flame filter press all needs through 120 DEG C of steam sterilizations more than 20 minutes.
Fill:
By the filtrate after ceramic membrane filter, use filling machine fill to the vial 500ml vial of sterilizing.This process need complete the toilet more than 100,000 grades, and relevant fill pipeline and equipment, Packaging Bottle need be passed through sterilization treatment.
In order to verify the curative effect of the fresh medicine fruit-vegerable ferment of the present invention spray coating liquor, prepared above-described embodiment 1 fresh medicine fruit-vegerable ferment spray coating liquor is as follows for the treatment situation record of 58 routine hair loss patients:
1, patient's situation
58 routine hair loss patients are divided into treatment group and matched group at random, treatment group 36 examples, wherein male's 21 examples, women's 15 examples, the course of disease is the shortest 1 month, the longest 5 years.Matched group 22 examples, are used commercially available * * hair lotion, wherein male's 14 examples, and women's 8 examples, the course of disease is the shortest 2 months, the longest 4 years.
2, using method: treatment group is sooner or later respectively once sprayed on alopecia place by fresh the present invention medicine fruit-vegerable ferment spray coating liquor every day, pats gently to absorbing, and 3 times repeatedly, before spray, after spray, all need not have one's hair wash.The using method that matched group is pressed on * * hair lotion is used.Using continuously 4 weeks is a course for the treatment of.
3, curative effect determinate standard;
Recovery from illness: the clinical symptoms signs such as hair stops undesired coming off, and the position that comes off all grows, bald disappear, it is normal that sebum secretion recovers;
Effective: hair stops undesired coming off, coming off regeneration reaches more than 70%, and the clinical symptoms sign such as bald is most of to disappear, and sebum secretion obviously reduces;
Effective: the clinical symptoms signs such as hair stops undesired coming off, and hair replacement reaches more than 30%, bald are clearly better;
Invalid: hair replacement less than 30%, the clinical symptoms sign such as bald is without improvement.
4, therapeutic effect
After one course for the treatment of, 13 examples of fully recovering in the routine patient for the treatment of group 36, cure rate 36.1%; Effective 14 examples, obvious effective rate 38.9%; Effective 5 examples, effective percentage 13.9%; Total effective rate reaches 89.9%; Invalid 4 examples, inefficiency is 11.1%.2 examples of fully recovering in the routine patient of matched group 22, cure rate 19.1%; Effective 5 examples, obvious effective rate 22.7%; Effective 6 examples, effective percentage 27.2%; Total effective rate reaches 59.1%; No effect 9, inefficiency is 40.9%.
After treatment, the some patients were of recovery from illness is ready openly concrete unit and the Real Name of oneself, they are: country of Ministry of Culture historical relic rescues the Deputy Chief of Branch Shu Yuting of group, the chief of office Hu Wen of Guangdong Medical College, the single national flag of the medicine president of business school of Guangdong Medical College, the detachment leader Chen Qi of Guigang, Guangxi fire-fighting detachment, Huanshixiang District, Huangshi, the former Hubei Province chairman of CPPCC model Guoqiang, former Hubei Province Huangshi wall is corrected director and is explained luxuriant inflammation.Several retired senior leader's ages have wherein exceeded 60 years old, and alopecia is very serious, and head hair is de-light almost, and only thin hair is enclosed in remaining back of head, a both sides one, all uses the product of various hair growths before, but DeGrain.The clear-cut abandoning cure having.Alopecia position all has grown brushy hair through using after the course for the treatment of of fresh medicine fruit-vegerable ferment spray coating liquor of the present invention! After joyful, continue again to use a course for the treatment of, the new slowly hardening blackening growing, has difficult to handle sensation.Therefore, be ready witness as product curative effect of the present invention.
5, conclusion (of pressure testing)
Because alopecia focus exposes, sick bit table is shallow, the fresh medicine fruit-vegerable ferment of the present invention spray coating liquor diseased region that can go directly, bacteriostasis and sterilization, dredges local meridians, improve hair follicle surrounding, dissolve superabundant fats, supply with full nutrition, make original root of hair firm, new growing, promotes hair growth promoting object thereby reach Anti-hair loss.The fresh medicine fruit-vegerable ferment of the present invention spray coating liquor character is very gentle, and or not containing the chemical composition of any scalp irritation root of hair, clinical test results does not prove that it has good phalacrosis prevention and hair generation effect really yet.
Claims (3)
1. the fresh medicine fruit-vegerable ferment spray coating liquor with Anti-hair loss and hair regrowth, is characterized in that being made up of the raw material of following weight parts:
Fresh Chinese crude drug 3-5 fresh fruit of vegetables 7-10
Brown sugar 1 pure water 8-12
Described fresh Chinese crude drug is made up of 2%-3% Cordyceps, 10%-30% Radix Polygoni Multiflori, 10%-30% Folium Pini, 10%-20% Rhizoma Zingiberis Recens, the 5%-20% Radix Astragali, 10%-20% Herba Ecliptae, 10%-20% Fructus Gleditsia and 10%-20% Fructus Mori by mass fraction, and the mass fraction sum of above-mentioned each Chinese medicine used is 100%;
In described fresh fruit of vegetables, the ratio of fruits and vegetables is 1: 1～3;
When preparation, respectively fresh Chinese crude drug, fresh fruit of vegetables are cleaned up, chop up, then get brown sugar, pure water adds in jar fermenter by proportioning, at 15-30 DEG C of bottom fermentation 3-6 month, opens air bleeding valve aerofluxus between yeast phase every 7-10 days; Ferment after one month, got fermentation liquid every 10-15 days and detect its pH value and total sugar content; When pH value is 3.0～3.5, total sugar content, between 0.8-1.5%, while being clarification light brown liquid, can finish fermentation after fermentation liquid is filtered with double gauze; Fermentation liquid coarse filtration is removed to residue, then filter with the flame filter press that 500 order filter clothes are housed, filtrate again via hole diameter is the purpose ceramic-film filter filtration of 1.4 μ m, collects filtrate; Finally gained filtrate is completed to fill in the toilet of 100,000 grades, to obtain final product; Pipeline, storage tank and the filter plant that filtrate after coarse filtration contacts all needs through 120 DEG C of steam sterilization 20-25 minute.
2. a kind of fresh medicine fruit-vegerable ferment spray coating liquor with Anti-hair loss and hair regrowth according to claim 1, is characterized in that: described fresh fruit of vegetables is this season fruits and vegetables.
3. as the preparation method of a kind of fresh medicine ferment spray coating liquor with Anti-hair loss and hair regrowth according to claim 1, it is characterized in that comprising the steps:
(1) pre-treatment
Get fresh Cordyceps, Radix Polygoni Multiflori, Rhizoma Zingiberis Recens, the Radix Astragali, Herba Ecliptae, Fructus Gleditsia, Fructus Mori, Folium Pini and fruit and vegetable, will wherein rot and impurity part is sorted out, clean with clear water; Be cut into small pieces respectively or strip by its shape facility, for subsequent use;
(2) mixed culture fermentation
Get respectively processed good fresh Chinese crude drug, fruit and vegetable and brown sugar, pure water by proportioning, be placed in jar fermenter, at 15-30 DEG C of bottom fermentation 3-6 month; Between yeast phase, opened air bleeding valve aerofluxus every 7-10 days; Ferment after one month, got fermentation liquid every 10-15 days and detect its pH value and total sugar content; When pH value is 3.0～3.5, total sugar content, between 0.8-1.5%, while being clarification light brown liquid, can finish fermentation after fermentation liquid is filtered with double gauze;
(3) fermentation liquor treatment
Fermentation liquid is removed to residue with double gauze coarse filtration, then filter with the flame filter press that 500 order gauzes are housed, filtrate again via hole diameter is the purpose ceramic-film filter filtration of 1.4 μ m, obtains filtrate;
(4) fill
By filtrate fill in 100,000 grades of toilets, to obtain final product; Pipeline, storage tank and the filter plant that filtrate after coarse filtration contacts all needs through 120 DEG C of steam sterilization 20-25 minute.
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