CN102631661A - Compound natural plant extract with hair renewal function, preparation method and applications thereof - Google Patents

Compound natural plant extract with hair renewal function, preparation method and applications thereof Download PDF

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CN102631661A
CN102631661A CN2012101431918A CN201210143191A CN102631661A CN 102631661 A CN102631661 A CN 102631661A CN 2012101431918 A CN2012101431918 A CN 2012101431918A CN 201210143191 A CN201210143191 A CN 201210143191A CN 102631661 A CN102631661 A CN 102631661A
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plant extract
natural plant
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CN102631661B (en
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王兴林
周艳芬
潘文杰
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Guangzhou Guerlain Cosmetics Co Ltd
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Abstract

The invention discloses a compound natural plant extract with hair renewal function, a preparation method and applications of the compound natural plant extract. The compound natural plant extract with hair renewal function is prepared from 50-100 parts of Polygonum Multiflorum, 45-90 parts of Radix Astragali, 20-50 parts of Radix Salviae Miltiorrhizae, 10-30 parts of Herba Ecliptae, 5-25 parts of Gastrodia Elata, 5-20 parts of Rhizoma Zingiberis, 5-10 parts of ginseng and 3-5 parts of Cordyceps Sinensis. The compound natural plant extract is obtained by extracting with ultrasonic wave technology, and filtering extracting solution with a micro-filtration film, and the compound natural plant extract can not cause anaphylactic reaction and toxic and side effects after being used for washing hairs. In addition, the ultrasonic wave is used for extracting, so that the extracting time is shortened, the damage to the effective contents caused by high-temperature heating can be avoided; the impurities in the extracting solution can be removed largely after the extracting solution is filtered by the micro-filtration film, and the active ingredients can be maintained, so that the obtained compound natural plant extract has obvious effect on treating alopecia.

Description

Have and educate the compound natural plant extract of sending out function and preparation method thereof and application
Technical field
The invention belongs to vegetable Chinese herbal medicine field and daily cosmetics technical field, particularly a kind of have educate the compound natural plant extract of sending out function and preparation method thereof and application.
Background technology
Modern society, because people's work, life stress are big, psychentonia makes much human alopecia alopecia phenomenon in various degree all occur.Daily in addition life and environment as hair is dyed, scalds, blows, draws, also have the external environment of contact every day, like ultraviolet, dry weather etc., can make hair become short-tempered, fragility, frangible even also can bring injury such as withered bifurcated.These inherences and external factor have directly influenced the health of scalp hair follicle cell; Reduce the speed and the quantity of new natural on-off cycles of hair growth, can shorten growth cycle of hair simultaneously, hair is not grown up as yet fully promptly get into resting stage; Quicken coming off of hair, make hair structure present relaxed state.
Have a lot of protecting and caring hair products on the market, these product great majority have added some functional chemical constituents, and the effect after using is general, and long-time use also can bring certain side effect to physical function; Educating of some pure Chinese medicine extraction sent out product because the prescription collocation is unreasonable; Consumer uses the back effect also undesirable, and product great majority on the market prepare product residual micromolecular Chinese medicine residue of meeting and dust with conventional method of extraction; Make product colour be dark-brown; Life-time service can run counter to desire on the contrary, stops up hair follicle, influences the metabolism of scalp.
Summary of the invention
Primary and foremost purpose of the present invention is to overcome the deficiency of above-mentioned prior art, and a kind of compound natural plant extract of educating a function that has is provided.This compound natural plant extract is applicable to various alopecias, uses the back not have irritated reaction, has no side effect, and medicine can infiltrate skin rapidly, improves the scalp microcirculation, and the nutrition hair follicle cell activates the purpose that hair follicle reaches hair growth promoting; It can also have the maintenance effect to impaired hair, and phenomenons such as correct scared hot-tempered, withered, jag all have good improvement.
Another object of the present invention adopts advanced ultrasonic wave extraction and membrane microfiltration technology, and rapid-action, good effect, few, the stay-in-grade a kind of method for preparing with the compound natural plant extract of educating a function of impurity are provided.
A purpose more of the present invention is to provide the described application of educating the compound natural plant extract of sending out function that has.
The object of the invention is realized through following technical proposals: a kind of have educate the compound natural plant extract of sending out function, prepare by following Chinese crude drug by mass parts:
Figure BDA00001619700900021
Described have educate the outbreak usefulness the compound natural plant extract, preferably prepare by following Chinese crude drug by mass parts:
Figure BDA00001619700900022
It is above-mentioned that to have method for distilling, a leaching process of compound natural plant extract of educating outbreak usefulness all unqualified.For example can adopt solvent extraction method, solvent is water, ultrasonic extraction, supercritical extraction etc.;
Described method for preparing with the compound natural plant extract of educating outbreak usefulness is preferably extracted with the micro-filtration membrane isolation technics through ultrasonic technique and is filtered, and comprises following steps:
(1) 50~100 mass parts Radix Polygoni Multiflori, 45~90 mass parts Radixs Astragali, 20~50 mass parts Radix Salviae Miltiorrhizaes, 10~30 mass parts Herba Ecliptaes, 5~25 mass parts Rhizoma Gastrodiaes, 5~20 mass parts Rhizoma Zingiberiss, 5~10 mass parts Radix Ginsengs and 3~5 mass parts Cordyceps are dry, crushing screening obtains coarse powder;
(2) in the coarse powder that step (1) obtains, add ethanol water, stir, dipping;
(3) coarse powder/ethanol water of obtaining of step (2) extracts under the ultrasound wave effect; Wherein, ultrasonic frequency is 20kHz, extracts 30~50 ℃ of temperature, extraction time 30~50min;
(4) extracting solution that step (3) is obtained carries out solid-liquid separation; The liquid filtering that obtains after the separation;
(5) with step (4) separate the filtering residue obtain set by step the condition of (2)~(4) carry out repetitive operation;
(6) liquid that step (4) and (5) is obtained merges, and is concentrated into relative density and is about 1.10~1.13, obtains having the compound natural plant extract of educating outbreak usefulness;
The degree of the pulverizing described in the step (1) is to cross 10 mesh sieves;
It is 60~80% that the concentration of the ethanol water described in the step (2) is preferably percent by volume; More preferably percent by volume 70%;
The consumption of the ethanol water described in the step (2) is preferably pressed solid-liquid ratio 1g: (7~20) ml calculates; More preferably calculate by material flowing fluid ratio 1g:10ml;
The time of the dipping described in the step (2) is preferably 1~2h;
Extraction temperature described in the step (3) is preferably 40 ℃;
Extraction time described in the step (3) is preferably 45min;
The mode of the solid-liquid separation described in the step (4) is preferably centrifugal;
Filtration described in the step (4) is preferably through using the inorganic ceramic micro-filtration membrane to filter;
The aperture of described inorganic ceramic micro-filtration membrane is preferably 1.0 μ m;
Described have educate the outbreak usefulness the application of compound natural plant extract in shampoo and/or hair care product.
Principle of the present invention:
The principal agent Radix Polygoni Multiflori the liver benefiting that nourishes blood in the present invention prescription, the controlling nocturnal emission with astringent drugs kidney tonifying, crow must hair color, is tonic medicine, and merit is on the Radix Rehmanniae, all medicines of Radix Asparagi.Modern pharmacological research proves that Radix Polygoni Multiflori has neural and the endocrine effect regulated, so the ability hairy root nourishing impels hair melanin to generate, makes hair shiny black; Its lecithin that is rich in is a kind of good hair conditioner, makes hair be easy to combing.
Invigorating QI to consolidate the body surface resistance of the Radix Astragali and Radix Salviae Miltiorrhizae, one restores menstrual flow and invigorates blood circulation, and pharmacological action proves that two medicines all can prevent cell senescence, all has the effect of microcirculation improvement, anticoagulant, and the both has excellent antibiotic active.Particularly Radix Salviae Miltiorrhizae rich in vitamin E and trace element zinc, copper, ferrum can promote the melanic growth of hair, also can replenish because of hair defectives such as poliosis that trace element zinc, copper, iron deficioncy cause, yellow hair, hair dryings.Add the Rhizoma Zingiberis cold expelling that induces sweat, Rhizoma Gastrodiae endogenous wind stopping relieving convulsion, dispelling wind and removing obstruction in the collateral, the Herba Ecliptae nourishing the liver and kidney is further dispeled ailment said due to cold or exposure, the hair care hair strengthening.And Rhizoma Zingiberis has the antiinflammatory anti-allergic effects, is the key medicine of controlling alopecia and giving birth to beard and hair.
Radix Ginseng can strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, and the ginsenoside is its main active component, the ginsenoside can promote protein synthesis, and the regeneration of Skin Cell is had very strong activation.The Cordyceps invigorating the lung and the kidney, real space between skin and muscles, cordycepin that it contains and Cordyceps mykol can obviously suppress the greasy release of scalp, and antiinflammatory antiallergic antioxidation is remarkable.
The present invention adopts the ultimate principle of ultrasonic wave extraction; The powerful shearing force of utilizing the ultrasonic cavitation effect to produce is broken plant cell wall, makes cell discharge content more easily, quickens effective ingredients in plant and leaches extraction; Hyperacoustic in addition second order effect; Like mechanical vibration, emulsifying, spread, smash, chemical effect etc., can quicken also that desire extracts that the diffusion of composition discharges and fully and solvent, be beneficial to extraction.The time that ultrasonic wave extraction can shorten extraction with improve extraction ratio, compare with conventional method, that ultrasonic extraction has is simple to operate, extract the required time short, extraction efficiency is high and need not advantage such as heating.
Chinese medicine extraction liquid contains a large amount of suspended solid microgranules, crude drug cell fragment and soluble high-molecular material (like starch, phlegmatic temperament, protein etc.); These impurity components in the extracting solution can influence the stability and the outward appearance of product; And filter methods such as traditional centrifugal separation, flocculation often can not be removed above-mentioned impurity effectively; Therefore need remove the impurity in the extract with better method, keep effective ingredient as much as possible.The micro-filtration membrane isolation technics is a kind of novel clarification impurity removing technology, and its main separation mechanism is that sieve aperture separates, and promptly film can be held back the solute bigger than its aperture, colloid and microgranule.Membrane separation technique and traditional compared with techniques have following advantage: 1. remove impurity is thorough, and the product clarity is high, and the microfiltration technology can be removed the solids of 0.025 ~ 10 μ m size; 2. loss of effective components is few; Product stability is high: middle pharmaceutically active ingredient molecular weight is generally below 1000, so microfiltration process generally do not hold back effective ingredient, and there is not the conversion of phase in membrane separation technique; Need not heat; Operating condition is gentle, needn't add chemical reagent, thus effective ingredient particularly the thermal sensitivity composition destroy few; 3. technology is simple, easy to operate, with short production cycle, and is energy-conservation, helps reducing the cost.
The present invention has following advantage and effect with respect to prior art:
(1) provided by the invention to have a prescription of educating the compound natural plant extract of sending out function reasonably combined according to Traditional Chinese medical theory, has functions of nourishing hair and growing hair, improves local blood circulation; Increase the nutrition supply of hair follicle, reduce sebum secretion, prevention follicular orifice hyperkeratosis; Trichogenous effect; Simultaneously can be antipruritic, antibacterial increases hair toughness;
(2) extract that obtains of the present invention can have good curative effect to various alopecias (nervous alopecia, seborrheic alopecia, alopecia areata, hypotrichosis, puerperal alopecia etc.) after being ill; The present invention is easily broken for the hair fragility that injuries such as hair-waving, hair dyeing, daylight ultraviolet cause, and withered short-tempered bifurcated etc. has good nutrition maintenance effect, and is bright, submissive, tough with the back blackout, and can make hair structure become tight;
(3) the present invention utilizes ultrasonic wave extraction to shorten extraction time, avoids the destruction of heat to effective ingredient, improves extraction ratio of effective constituents, has overcome the shortcoming that exists in the Chinese medicine method for distilling.The micro-filtration membrane isolation technics is filtered extracting solution, can effectively remove macromole impurity, keeps effective ingredient morely.Make extract color of the present invention be the clarification magma, medicine can infiltrate scalp rapidly.Method for preparing of the present invention is simple, and the big time saver and the energy help reducing cost.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail, but embodiment of the present invention is not limited thereto.
Embodiment 1
(1) Radix Polygoni Multiflori, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Ecliptae, Rhizoma Gastrodiae, Rhizoma Zingiberis, Radix Ginseng and Cordyceps are handled respectively as follows: drying, pulverize through pulverizer, cross 10 mesh sieves, obtain coarse powder;
(2) Radix Polygoni Multiflori, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Ecliptae, Rhizoma Gastrodiae, Rhizoma Zingiberis, Radix Ginseng and Cordyceps powder coarse powder are pressed mass ratio 60:50:25:20:15:10:5:3 mixing, obtain mixed medicinal materials medicated powder;
(3) in the mixed medicinal materials medicated powder that step (2) obtains, add percent by volume 70% ethanol water, calculate by 1g solid proportioning 10ml 70% ethanol water; Then stir dipping 2h;
(4) material liquid mixture that step (3) is obtained extracts under the ultrasound wave effect, and ultrasonic frequency is 20kHz, extracts 40 ℃ of temperature, extraction time 45min;
(5) extracting solution that step (4) is obtained carries out centrifugal, and rotating speed is 10000r/min; The liquid passage aperture that obtains after centrifugal is the inorganic ceramic micro-filtrate membrane filtration of 1.0 μ m;
(6) with step (5) separate the filtering residue obtain set by step the condition of (3)~(5) carry out repetitive operation;
(7) liquid that step (5) and (6) is obtained merges, and filtrating is concentrated into relative density and is about 1.10~1.13, obtains having the compound natural plant extract of educating outbreak usefulness.
(8) the compound natural plant extract of educating outbreak usefulness that has that step (7) is prepared mixes by mass ratio 1:17 in the ethanol water of percent by volume 55%, obtains Chinese medicine hair nourishing liquid I.
Embodiment 2
(1) with embodiment 1 step (1);
(2) Radix Polygoni Multiflori, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Ecliptae, Rhizoma Gastrodiae, Rhizoma Zingiberis, Radix Ginseng and Cordyceps powder coarse powder are pressed mass ratio 80:80:40:30:25:20:8:3 mixing, obtain mixed medicinal materials medicated powder;
(3) in the mixed medicinal materials medicated powder that step (2) obtains, add percent by volume 70% ethanol water, calculate by 1g solid proportioning 10ml 70% ethanol water; Then stir dipping 2h;
(4) material liquid mixture that step (3) is obtained extracts under the ultrasound wave effect, and ultrasonic frequency is 20kHz, extracts 40 ℃ of temperature, extraction time 45min;
(5) extracting solution that step (4) is obtained carries out centrifugal, and rotating speed is 10000r/min; The liquid passage aperture that obtains after centrifugal is the inorganic ceramic micro-filtrate membrane filtration of 1.0 μ m;
(6) with step (5) separate the filtering residue obtain set by step the condition of (3)~(5) carry out repetitive operation;
(7) liquid that step (5) and (6) is obtained merges, and filtrating is concentrated into relative density and is about 1.10~1.13, obtains having the compound natural plant extract of educating outbreak usefulness.
(8) the compound natural plant extract of educating outbreak usefulness that has that step (7) is prepared mixes by mass ratio 1:17 in the ethanol water of percent by volume 55%, obtains Chinese medicine hair nourishing liquid II.
Embodiment 3
(1) with embodiment 1 step (1);
(2) Radix Polygoni Multiflori, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Ecliptae, Rhizoma Gastrodiae, Rhizoma Zingiberis, Radix Ginseng and Cordyceps powder coarse powder are pressed mass ratio 50:90:20:30:5:20:10:5 mixing, obtain mixed medicinal materials medicated powder;
(3) in the mixed medicinal materials medicated powder that step (2) obtains, add percent by volume 70% ethanol water, calculate by 1g solid proportioning 7ml 70% ethanol water; Then stir dipping 2h;
(4) material liquid mixture that step (3) is obtained extracts under the ultrasound wave effect, and ultrasonic frequency is 20kHz, extracts 45 ℃ of temperature, extraction time 40min;
(5) extracting solution that step (4) is obtained carries out centrifugal, and rotating speed is 10000r/min; The liquid passage aperture that obtains after centrifugal is the inorganic ceramic micro-filtrate membrane filtration of 1.0 μ m;
(6) with step (5) separate the filtering residue obtain set by step the condition of (3)~(5) carry out repetitive operation;
(7) liquid that step (5) and (6) is obtained merges, and filtrating is concentrated into relative density and is about 1.10~1.13, obtains having the compound natural plant extract of educating outbreak usefulness.
(8) the compound natural plant extract of educating outbreak usefulness that has that step (7) is prepared mixes by mass ratio 1:17 in the ethanol water of percent by volume 55%, obtains Chinese medicine hair nourishing liquid III.
Embodiment 4
(1) with embodiment 1 step (1);
(2) Radix Polygoni Multiflori, the Radix Astragali, Radix Salviae Miltiorrhizae, Herba Ecliptae, Rhizoma Gastrodiae, Rhizoma Zingiberis, Radix Ginseng and Cordyceps powder coarse powder are pressed mass ratio 100:45:50:10:5:5:10:4 mixing, obtain mixed medicinal materials medicated powder;
(3) in the mixed medicinal materials medicated powder that step (2) obtains, add percent by volume 70% ethanol water, calculate by 1g solid proportioning 20ml 70% ethanol water; Then stir dipping 2h;
(4) material liquid mixture that step (3) is obtained extracts under the ultrasound wave effect, and ultrasonic frequency is 20kHz, extracts 40 ℃ of temperature, extraction time 45min;
(5) extracting solution that step (4) is obtained carries out centrifugal, and rotating speed is 10000r/min; The liquid passage aperture that obtains after centrifugal is the inorganic ceramic micro-filtrate membrane filtration of 1.0 μ m;
(6) with step (5) separate the filtering residue obtain set by step the condition of (3)~(5) carry out repetitive operation;
(7) liquid that step (5) and (6) is obtained merges, and filtrating is concentrated into relative density and is about 1.10~1.13, obtains having the compound natural plant extract of educating outbreak usefulness.
(8) the compound natural plant extract of educating outbreak usefulness that has that step (7) is prepared mixes by mass ratio 1:17 in the ethanol water of percent by volume 55%, obtains Chinese medicine hair nourishing liquid IV.
The comparative example 1
(1) with embodiment 1 step (1);
(2) with embodiment 1 step (2);
(3) in the mixed medicinal materials medicated powder that step (2) obtains, add entry, press 1g solid proportioning 20ml water and calculate; Then stir; Soak 30min;
(4) boil extraction 90min, take out extracting solution, filter, obtain filtrating;
(5) add water again in extraction pot, repeating step (4) obtains filtrating;
(6) filtrating that step (4) and (5) is obtained merges, and concentrates, and is cooled to 40 ℃; Then under stirring, add percent by volume 95% ethanol, making the extracting solution that finally obtains is that to contain the alcohol amount be 40% mixed liquor;
(7) airtight placement 12h, this moment, deposition was complete;
(8) remove by filter deposition, reclaim ethanol, obtain concentrated solution;
(9) use 500 order filter cloth filtering and concentrating liquid, obtain Chinese medicine hair nourishing liquid V.
Effect embodiment
The Chinese medicine hair nourishing liquid that above embodiment is prepared carries out activity test, with observing effect.
The experiment number of every kind of hair nourishing liquid is 20 people, male 10 examples, and women 10 examples all have pathologic baldness shape, the age: 18~45 years old.
Method for using: external, every day 1 time, each 2-5ml is applied to the soft extremely heating in alopecia position with these article, and using 1 month continuously is 1 course of treatment, and 6 courses of treatment are as observation of curative effect.
Experimental result:
Criterion of therapeutical effect is divided into: (1) produce effects: do not have obvious alopecia, have a large amount of new hairs to generate; (2) effective: alopecia is controlled, has a small amount of new hair to generate; (3) invalid: no change before and after the treatment.
The curative effect of Chinese medicine hair nourishing liquid is as shown in table 1.
Table 1
Produce effects Effectively Invalid Total effective rate
Chinese medicine hair nourishing liquid I 16 4 0 100%
Chinese medicine hair nourishing liquid II 15 3 2 95%
Chinese medicine hair nourishing liquid III 14 3 3 85%
Chinese medicine hair nourishing liquid IV 13 4 3 85%
Chinese medicine hair nourishing liquid V 10 2 8 60%
The clinical trial process shows, uses Chinese medicine hair nourishing liquid I~IV, and speckle takes off with male pattern alopecia can grow New Development in average 25 days; Use Chinese medicine hair nourishing liquid V, speckle takes off with male pattern alopecia average 40 and just grows New Development.
Can know through The above results, more effective through the Chinese medicine hair nourishing liquid that ultrasonic extraction obtains than the Chinese medicine hair nourishing liquid that traditional heating extraction obtains.
The foregoing description is a preferred implementation of the present invention; But embodiment of the present invention is not restricted to the described embodiments; Other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; All should be the substitute mode of equivalence, be included within protection scope of the present invention.

Claims (10)

1. one kind has the compound natural plant extract of educating a function, it is characterized in that being prepared by following Chinese crude drug by mass parts:
Figure FDA00001619700800011
2. according to claim 1 have educate the outbreak usefulness the compound natural plant extract, it is characterized in that preparing by following Chinese crude drug by mass parts:
Figure FDA00001619700800012
3. claim 1 is described has a method for preparing of compound natural plant extract of educating outbreak usefulness, it is characterized in that comprising following steps:
(1) 50~100 mass parts Radix Polygoni Multiflori, 45~90 mass parts Radixs Astragali, 20~50 mass parts Radix Salviae Miltiorrhizaes, 10~30 mass parts Herba Ecliptaes, 5~25 mass parts Rhizoma Gastrodiaes, 5~20 mass parts Rhizoma Zingiberiss, 5~10 mass parts Radix Ginsengs and 3~5 mass parts Cordyceps are dry, crushing screening obtains coarse powder;
(2) in the coarse powder that step (1) obtains, add ethanol water, stir, dipping;
(3) coarse powder/ethanol water of obtaining of step (2) extracts under the ultrasound wave effect; Wherein, ultrasonic frequency is 20kHz, extracts 30~50 ℃ of temperature, extraction time 30~50min;
(4) extracting solution that step (3) is obtained carries out solid-liquid separation; The liquid filtering that obtains after the separation;
(5) with step (4) separate the filtering residue obtain set by step the condition of (2)~(4) carry out repetitive operation;
(6) liquid that step (4) and (5) is obtained merges, and is concentrated into relative density and is about 1.10~1.13, obtains having the compound natural plant extract of educating outbreak usefulness.
4. the method for preparing with the compound natural plant extract of educating outbreak usefulness according to claim 3 is characterized in that: the degree of the pulverizing described in the step (1) is for crossing 10 mesh sieves.
5. the method for preparing with the compound natural plant extract of educating outbreak usefulness according to claim 3, it is characterized in that: the concentration of the ethanol water described in the step (2) is mass volume ratio 60~80%;
The consumption of the ethanol water described in the step (2) is by expecting flowing fluid ratio 1: calculate (7~20);
The time of the dipping described in the step (2) is 1~2h.
6. the method for preparing with the compound natural plant extract of educating outbreak usefulness according to claim 5, it is characterized in that: the concentration of the ethanol water described in the step (2) is percent by volume 70%;
The consumption of the ethanol water described in the step (2) calculates by material flowing fluid ratio 1:10.
7. the method for preparing with the compound natural plant extract of educating outbreak usefulness according to claim 3, it is characterized in that: the extraction temperature described in the step (3) is 40 ℃;
Extraction time described in the step (3) is 45min.
8. the method for preparing with the compound natural plant extract of educating outbreak usefulness according to claim 3, it is characterized in that: the mode of the solid-liquid separation described in the step (4) is centrifugal;
Being filtered into described in the step (4) through using the inorganic ceramic micro-filtration membrane to filter.
9. the method for preparing with the compound natural plant extract of educating outbreak usefulness according to claim 8, it is characterized in that: the aperture of described inorganic ceramic micro-filtration membrane is 1.0 μ m.
Claim 1 or 2 described have educate the outbreak usefulness the application of compound natural plant extract in shampoo and/or hair care product.
CN201210143191.8A 2012-05-09 2012-05-09 Compound natural plant extract with hair renewal function, preparation method and applications thereof Active CN102631661B (en)

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