CN106511924A - Externally-applied pharmaceutical composition for treating alopecia and promoting hair growth and preparation method thereof - Google Patents
Externally-applied pharmaceutical composition for treating alopecia and promoting hair growth and preparation method thereof Download PDFInfo
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- CN106511924A CN106511924A CN201610975084.XA CN201610975084A CN106511924A CN 106511924 A CN106511924 A CN 106511924A CN 201610975084 A CN201610975084 A CN 201610975084A CN 106511924 A CN106511924 A CN 106511924A
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- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- 235000007063 yellowwood Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses an externally-applied pharmaceutical composition for treating alopecia and promoting hair growth and a preparation method thereof and belongs to the field of the traditional Chinese medicine. The externally-applied pharmaceutical composition disclosed by the invention is prepared from the following raw medicine components in parts by weight: 60 to 120 parts of eclipta, 30 to 60 parts of polygonum multiflorum, 50 to 100 parts of folium mori, 30 to 60 parts of cacumen biotae, 50 to 100 parts of the root of red-rooted salvia, 20 to 110 parts of cedar camphor and 5 to 10 parts of pumpkin seed oil; or the following raw medicine components can be added as well: 30 to 50 parts of Chinese starjasmine stems, 25 to 55 parts of fresh gingers and 10 to 20 parts of lilac daphne flower bud. By adopting extracted components of traditional Chinese medicines, the pharmaceutical composition disclosed by the invention has the effects of promoting the metabolism function of the scalp and nutrient absorption of the hair roots to effectively cure the alopecia and can also have the effects of promoting blood circulation to remove blood stasis and stimulating the growth of hair follicles so as to achieve the function of promoting regrowth of the hair.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, more particularly to a kind of for hair growth, the external used medicine of promotion hair growth promoting
Compositionss and preparation method thereof, belong to technical field of Chinese medicine.
Background technology
Record about alopecia is seen earliest《Interior Jing》, referred to as alopecia areata,trichomadesis, deal with, trichomadesis.With social development, work section
Play, the change of the external environment condition such as life style, alopecia is not only by empty and cause, even more due to increase and the drink of stress
A kind of caused hair loss disorder of simulataneous insufficiency and excessive of unbalance institute of food.Alopecia is modern clinic common disease, though it is not belonging to serious disease
Disease, but affect people it is spiritual, psychological and vivid, the life that alopecia also gives people brings endless worry.People are to cosmetology
Requirement it is increasingly urgent, modern medicine and traditional medicine also increasingly pay attention to the research to alopecia.
Alopecia (alopecia) disease, is belonged to the disease scope such as traditional Chinese medical science " alopecia areata " " alopecia areata ", is clinical common disease, is subtracted with hair
It is characterized less.Alopecia is the lysis that a kind of multifactor participation causes to fall ill, and infection, hormone, immunity, heredity are all its morbidities
During important factor in order, the inflammatory injury of hair follicle is probably the immediate cause for causing alopecia.Alopecia disease
Including alopecia areata, androgenetic alopecia (also known as male pattern alopecia, seborrheic alopecia), alopecia due to chemotherapy, senile alopecia, cicatrix
The property type such as alopecia and psychogenic alopecia.Hair loss patient is frequently due to some factors causes hair to enter hair too early by trophophase
There is long resting stage, hair follicle and ball top atrophy, be changed into thin hair and caused from terminal hair.
Alopecia areata mostly is limitation patch shape alopecia, and the small number of patients state of an illness is more serious, may occur in which alopecia totalis or alopecia universalis.Pathogenic factor
It is unclear, think relevant with psychentonia and fatigue more.More as deficiency of the liver and kindey, ailment said due to cold or exposure are taken advantage of a weak point, or stagnation of QI due to depression of the liver, hair
Send out to lose and support caused.Alopecia areata often occurs suddenly, many no conscious symptons, non-cicatrical, struvite circular or oval in limitation
Patch shape alopecia, not of uniform size, boundary is obvious.The patients with alopecia areata early stage hair development of visible trophophase is bad, perifollicolar
CD4 +T cell infiltrates.Late period visible hair follicle atrophy, hair and hair papilla diminish, and the non-full-shape of new setation, intradermal are visible
Vasculitises and periangiitis, blood vessel reticular density are reduced.
Androgenetic alopecia has family history, is the hereditary alopecia disease of androgen-dependent.Account for the 90% of all alopecias.
Generally believe that the disease is a kind of disease of multifactorial inheritance of Androgen-dependent in recent years.Androgenetic alopecia includes male pattern alopecia
And female alopecia, it is mainly shown as the gradual alopecia at head E Nie areas and top, androgen levels of hair loss patient and normal
People is close, and the hair follicle of this patient is congenital to Androgen-sensitive, can suppress its generation as 5- α dihydrotestosteronees are gathered in hair follicle
Apologize for having done sth. wrong journey.Its cause of disease and pathogeny are complicated, it is now recognized that the Developmental and Metabolic Disorder of genetic predisposition and scalp hair follicles local androgen
It is to cause this pathogenetic principal element.
Seborrheic alopecia is then more common in male person between twenty and fifty, often shows as from the beginning of forehead and both sides alopecia, gradually symmetrically to head
Top extends, the very thin rareness of hair, feels prurituss, and vigorous with scalp sebum secretion.Main pathological manifestations are resting stage
Hair follicle increasing number, the hair follicle quantity in growth whole latter stage are reduced, and hair follicle is substantially miniaturized, and trophophase shortens, and course of disease latter stage can have
Inflammation and fibrosiss.Seborrheic alopecia mostly is deficiency in origin and excess in superficiality or simulataneous insufficiency and excessive disease, and long-term psychological unbalance, courses of infection, diet lose
Adjust, psychentonia can induce or increase the state of an illness.
The product of hair growth is numerous and diverse on the market now, and western medicine baldness is mainly hormone regulator, hormonal regulation
Agent has endocrine therapy agent and estrogen-mediated agent etc., but these drug prices are higher, and side effect is relatively large, is also easy to produce drug resistance
Property, be not suitable for patient's life-time service；The treatment by Chinese herbs baldness time is very long, slowly effect, for the effect of head hair follicle is also compared
It is limited, and have the possibility for increasing lesions of liver and kidney；There are the hair care product of some hair growths, but complex chemical composition, contain
There are harmful chemical products, side effect is larger, is difficult life-time service, so the medicine in focus affected part can really be reached very
It is limited.
The present invention studies alopecia etiology and pathogenesis on the basis of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treats each to adjust QI and blood, detoxification and removing stasis
The alopecia disease of type, not only can enhance metabolism function, promote hair root nutrients to absorb, and can be with blood circulation promoting and blood stasis dispelling
Grow with hair follicle stimulating.The present invention adopts natural Chinese medicines extract component, promotes hair restoration, and significantly, poison is secondary to be made therapeutic effect
With little, it is the specific drug of hair growth.
The content of the invention
It is an object of the invention to provide can be used for hair growth, the externally-applied medicinal composition for promoting hair growth promoting and its preparation side
Method.
In order to achieve the above object, following technological means be present invention employs：
The present invention's is a kind of for hair growth, the externally-applied medicinal composition of promotion hair growth promoting, by the original of following parts by weight
Material medicine is made：Herba Ecliptae 60-120 parts, Radix Polygoni Multiflori 30-60 parts, Folium Mori 50-100 parts, Cacumen Platycladi 30-60 parts, Radix Salviae Miltiorrhizae 50-100
Part, cedar wood alcohol 20-110 parts and Semen Cucurbitae oil 5-10 parts.
In the present invention, it is preferred to, described externally-applied medicinal composition is made up of the crude drug of following parts by weight：Black drought
Lotus 80-100 parts, Radix Polygoni Multiflori 40-50 parts, Folium Mori 60-90 parts, Cacumen Platycladi 30-60 parts, Radix Salviae Miltiorrhizae 60-90 parts, cedar wood alcohol 40-90 parts
And Semen Cucurbitae oil 5-10 parts.
It is furthermore preferred that described externally-applied medicinal composition is made up of the crude drug of following parts by weight：90 parts of Herba Ecliptae, what
7 parts of 45 parts of the Radix Polygoni Multiflori, 75 parts of Folium Mori, 45 parts of Cacumen Platycladi, 75 parts of Radix Salviae Miltiorrhizae, 65 parts of cedar wood alcohol and Semen Cucurbitae oil.
Another of the present invention is used for hair growth, promotes the externally-applied medicinal composition of hair growth promoting, by following parts by weight
Crude drug is made：Herba Ecliptae 60-120 parts, Radix Polygoni Multiflori 30-60 parts, Folium Mori 50-100 parts, Cacumen Platycladi 30-60 parts, Radix Salviae Miltiorrhizae 50-100
Part, cedar wood alcohol 20-110 parts, Caulis Trachelospermi 30-50 parts, Rhizoma Zingiberis Recenss 25-55 parts, Flos Genkwa 10-20 parts and Semen Cucurbitae oil 5-10 parts.
In the present invention, it is preferred to, described externally-applied medicinal composition is made up of the crude drug of following parts by weight：Black drought
Lotus 80-100 parts, Radix Polygoni Multiflori 40-50 parts, Folium Mori 60-90 parts, Cacumen Platycladi 30-60 parts, Radix Salviae Miltiorrhizae 60-90 parts, cedar wood alcohol 40-90 parts,
Caulis Trachelospermi 35-45 parts, Rhizoma Zingiberis Recenss 30-45 parts, Flos Genkwa 10-15 parts and Semen Cucurbitae oil 5-10 parts.
It is furthermore preferred that described externally-applied medicinal composition is made up of the crude drug of following parts by weight：90 parts of Herba Ecliptae, what
45 parts of the Radix Polygoni Multiflori, 75 parts of Folium Mori, 45 parts of Cacumen Platycladi, 75 parts of Radix Salviae Miltiorrhizae, 65 parts of cedar wood alcohol, 40 parts of Caulis Trachelospermi, 40 parts of Rhizoma Zingiberis Recenss, 15 parts of Flos Genkwa
And 7 parts of Semen Cucurbitae oil.
In the Chinese medicine composition for hair growth of the present invention, the function of each component is as follows：
Herba Ecliptae also known as Eclipta prostrata, Herba Ecliptae, Herba Ecliptae, belong to the plant of Compositae Eclipta prostrata.For the herb of feverfew Eclipta prostrata, often
Nian Xia, two season of autumn extract herb, remove silt, dry or be used as medicine by drying in the shade.This product original name Eclipta prostrata, begins to be loaded in《Tang materia medica》.
《Jing is herbal for figure》Claim Herba Ecliptae.Li Shizhen (1518-1593 A.D.) is said：" Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) has two kinds：One seedling, like sheathed and grey thin person, is Eclipta prostrata；A kind of flower
It is yellow purple and tie room such as Receptaculum Nelumbiniss person, be that little lotus sticks up ... ".Ming Dynasty's Li Shizhen (1518-1593 A.D.) exists《Compendium of Materia Medica》In write：" Herba Ecliptae, crow
Beard and hair, kidney tonifying are cloudy ".He is thought in Chinese herbal medicine, even if the optimal drug Herba Ecliptae of poliosis blackening can be made.Herb is medicinal, also
There are convergence, hemostasis, invigorating the liver and kidney.Nature and flavor：It is sweet, sour, tremble with fear.Return through：Return kidney, Liver Channel.Indication：Nourishing the liver and kidney, removing heat from blood
Hemostasis.For odontoseisiies, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery collapse
Leak down blood, traumatic hemorrhage.
Radix Polygoni Multiflori also known as spend more knotweed, purple crow rattan, Caulis Polygoni Multiflori etc..It is that Polygonaceae knotweed race Radix Polygoni Multiflori belongs to perennial winding liana plant
Thing, tuber are plump, oblong, pitchy.Raw mountain valley shrubbery, hillside sylvan life, ditch curb gap.Its tuber is used as medicine, and can calm the nerves, support
Blood, active, removing toxic substances (preventing the attack (or recurrence) of malaria), eliminating carbuncle.Nature and flavor：Bitter sweet is puckery, tepor.Return through：Enter liver and kidney channel.Indication：Nourishing the blood and yin；Profit
Intestinal relieving constipation；Preventing the attack (or recurrence) of malaria；Wind-dispelling；Removing toxic substances.Main blood deficiency Light-headedness；Cardiopalmus；Insomnia；The soreness of the waist and knees of the hepatic and renal YIN deficiency；Early whitening of beard and hair；Ear
Ring；Seminal emission；Dry constipation of intestines；Chronic malaria body void；Rubella itch；Carbuncle sore；Scrofula；Hemorrhoid.
Folium Mori are the dried leaves of moraceae plants mulberry, also known as mulberry, thorn mulberry, mulberry fruit tree, yellow wood etc..China north and south various places are extensive
Plantation mulberry, mulberry yield are enriched, and gas is light, and mildly bitter flavor is puckery, medicinal it is generally acknowledged that the person's of adopting matter is good after frost.Nature and flavor：Bitter in the mouth；It is sweet；Property
It is cold.Return through：Enter lung, Liver Channel.Indication：Dispelling wind and heat pathogens；Lung heat clearing；Improving eyesight.Main anemopyretic cold；Pathogenic wind-warm is from the beginning of, fever and headache, antiperspirant
Go out aversion to wind, chest pain of coughing；Or dryness of the lung dry cough without phlegm；Dry throat and mouth；Disturb on wind heat and liver-yang；Conjunctival congestion and swelling pain.For anemopyretic cold,
Lung-heat type cough, dizziness headache, conjunctival congestion are dim-sighted.
Cacumen Platycladi also known as Cupressus funebris, gold zone cypress, are aiphyllium, and its twig, leaf and fruit can be all used as medicine, and its bitter in the mouth, puckery, property is micro-
It is cold, enter lung, liver, large intestine channel, have functions that cooling blood for hemostasis, black beard and hair, cough-relieving are breathed heavily.It is mainly used in the hemorrhagic disease that bleeding due to blood-heat causes
Disease, and have antitussive, eliminating the phlegm, blood pressure lowering, Anti-hair loss etc. to act on.Kernel in its fruit then has the effect of tranquilizing by nourishing the heart, loosening bowel to relieve constipation.
Nature and flavor：It is bitter, puckery, tremble with fear.Return through：Return lung, liver, spleen channel.Effect：Cooling blood for hemostasis, preventing phlegm from forming and stopping coughing, growing and blacking hair.
Radix Salviae Miltiorrhizae also known as Radix Salviae Miltiorrhizae, SHANSHEN, Radix Salviae Miltiorrhizae, Arisaema balansae Engl. etc., are the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Spring, autumn
Two seasons excavated, and removed silt, were dried.National most area is all distributed.Nature and flavor：Hardship, tepor.Return through：Enter the heart, Liver Channel.Work(
Can cure mainly：Blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, the accumulation of abdominal mass abdominal mass, heat
Numbness pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea, sore swell and ache curative.
Cedar wood alcohol is widely present in the volatile oil of the various plants such as Cupressaceae, Taxodiaceae and Pinaceae also known as cedrol and cedrol
In.The making of spice is applied not only to, also with antiinflammatory, antibacterial, calmness, solution spasm, anti-cardiovascular disease, defying age and antitumor
Etc. multiple pharmacological effect and biologic activity.
Dry zone leaf rattan of the Caulis Trachelospermi for apocynaceae plant trachelospermum jasminoide.Winter is tapped to secondary spring, is removed impurity, is dried.
Cold nature, bitter in the mouth.Dispelling wind and removing obstruction in the collateral, cool blood detumescence.For beriberoid pyretic arthralgia, muscle arteries and veins contraction, soreness of waist and knee joint, sore throat, carbuncle, fall and flutter damage
Wound.It is distributed in the ground such as Henan, Shandong, Anhui, Jiangsu, Zhejiang, Fujian.
Rhizoma Zingiberis Recenss are the new fresh quench stems of Zingiberaceae herbaceos perennial Rhizoma Zingiberis Recens, and the rhizome of Rhizoma Zingiberis Recens, cork, leaf can be used as medicine.Rhizoma Zingiberis Recenss exist
There is in Chinese medicine and pharmacy the effects such as diverging, preventing or arresting vomiting, cough-relieving.Indication：Deliver, cold expelling, preventing or arresting vomiting opens expectorant.Cure cold wind and cold, vomits
Tell, phlegm retention is breathed with cough, distension is had loose bowels；The solution Rhizoma Pinelliae, Rhizoma Arisaematiss and ichthyophagy crab, birds and beasts meat poisoning.
The dry flower of Flos Genkwa Isolated From Thymelaeaceae Species Flos Genkwa, its root white skin (double-layer fur) also hyoscine.When spring flower is not opened
Harvesting, removes impurity.It is dried.Nature and flavor：It is arduous, temperature.Return through：Enter lung, spleen channel.Indication：Removing fluid-retention by purgation；Expelling phlegm for arresting cough；Solution
Poisoning worm.Main edema；Expansion；Phlegm retention hydrothorax；Breath with cough；Carbuncle furuncle tinea.
Semen Cucurbitae oil are called Semen Benincasae oil, pumpkin seed oil.Semen Cucurbitae oil are with high-quality Semen Cucurbitae kernel as raw material, with tradition
Squeezing process is refined to be formed, and is sufficiently reserved the nutrition elite of pumpkin seed, is the health-nutrition oil for having prominent male health-care effect.
Semen Cucurbitae oil contain abundant unsaturated fatty acid, such as linolenic acid, linoleic acid etc..Additionally, Semen Cucurbitae oil also containing plant sterol,
The various bioactivators such as aminoacid, vitamin, mineral, especially zinc, magnesium, calcium, phosphorus content are high.
Crude drug used in the present invention can be commercially available from common pharmacy, and its specification meets national medicine mark
It is accurate.
Further, the invention provides the hair growth, the preparation method of the externally-applied medicinal composition of promotion hair growth promoting, bag
Include following steps：
(1) each crude drug is weighed by parts by weight of the present invention；
(2) extract：
Other crude drug in addition to Semen Cucurbitae oil and cedar wood alcohol are put in extraction pot, is added water to cook twice, add for the first time
Enter the water of total 8-10 times of weight of medical material, decoct 1-2 hours, take decocting liquid, 8-10 times of total medical material is added in medicinal residues for the second time and is weighed
The water of amount, decocts 1-2 hours, takes decocting liquid twice and merges, filters, be evaporated to relative density at 60 DEG C for 1.10～
The concentrated solution of 1.30g/ml, then the ethanol solution of 2-3 times of volume is added in concentrated solution, filter, collect concentrated solution；
(3) mix：
The wetting agent of 50-120 weight portions, mix homogeneously are added to concentrated solution；Semen Cucurbitae oil and cedar wood alcohol are eventually adding, are stirred
Dissolving is mixed, mix homogeneously obtains final product described externally-applied medicinal composition.
In method of the present invention, it is preferred that described in step (2), the mass percent concentration of ethanol solution is
70%-80%.
In method of the present invention, it is preferred that wetting agent described in step (3) selected from glycerol, Polyethylene Glycol, the third two
One or more combination in alcohol, chitin, hyaluronic acid and pyrrolidone sodium carboxylate.
Further, the invention allows for described externally-applied medicinal composition is preparing hair growth, promoting hair growth promoting
External used medicine in purposes.
The present invention studies alopecia etiology and pathogenesis on the basis of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, using traditional Chinese medicine extraction component, with adjust QI and blood,
Detoxification and removing stasis can not only promote the metabolic function and hair root nutrients of scalp to inhale treating various types of alopecia diseases
Receive, effectively treatment alopecia, and the effect for promoting hair restoration can be reached so that blood circulation promoting and blood stasis dispelling, hair follicle stimulating grow.It is applied to
Clinic, for hair growth, promotes hair growth promoting to achieve ideal therapeutic effect.
Specific embodiment
Below by experiment in conjunction with specific embodiments further describing the present invention, advantages of the present invention and feature will be with
Description and it is apparent.But these embodiments are only exemplary, do not constitute any restriction to the scope of the present invention.Ability
Field technique personnel should be understood that without departing from the spirit and scope of the invention can be to the details of technical solution of the present invention
Modify with form or replace, but these modifications and replacement are each fallen within protection scope of the present invention.
The preparation of 1 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight：
Herba Ecliptae 90g, Radix Polygoni Multiflori 45g, Folium Mori 75g, Cacumen Platycladi 45g, Radix Salviae Miltiorrhizae 75g, cedar wood alcohol 65g, Caulis Trachelospermi 40g, life
Rhizoma Zingiberis Recens 40g, Flos Genkwa 15g and Semen Cucurbitae oil 7g；
(2) extract：
Herba Ecliptae, Radix Polygoni Multiflori, Folium Mori, Cacumen Platycladi, Radix Salviae Miltiorrhizae, Caulis Trachelospermi, Rhizoma Zingiberis Recenss, Flos Genkwa are put in extraction pot, is added water to cook
Twice, the water of 10 times of weight of total medical material is added for the first time, is decocted 2 hours, is taken decocting liquid, add total medical material for the second time in medicinal residues
The water of 8 times of weight, decocts 1.5 hours, takes decocting liquid twice and merges, filters, and being evaporated to relative density at 60 DEG C is
1.20g/ml concentrated solution.The mass percent concentration for adding 2-3 times of volume again toward concentrated solution is 75% ethanol solution,
Filter, collect concentrated solution；
(3) mix：
50g glycerol and 50g PEG400s, mix homogeneously are added in concentrated solution；It is eventually adding Semen Cucurbitae oil and Cupressus funebris Endl.
Alcohol, stirring and dissolving, mix homogeneously obtain final product medicinal liquid.
The preparation of 2 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight：
Herba Ecliptae 120g, Radix Polygoni Multiflori 60g, Folium Mori 80g, Cacumen Platycladi 60g, Radix Salviae Miltiorrhizae 80g, cedar wood alcohol 100g, Caulis Trachelospermi 50g,
Rhizoma Zingiberis Recenss 50g, Flos Genkwa 20g and Semen Cucurbitae oil 10g；
(2) extract：
Herba Ecliptae, Radix Polygoni Multiflori, Folium Mori, Cacumen Platycladi, Radix Salviae Miltiorrhizae, Caulis Trachelospermi, Rhizoma Zingiberis Recenss, Flos Genkwa are put in extraction pot, is added water to cook
Twice, the water of 10 times of weight of total medical material is added for the first time, is decocted 1.5 hours, is taken decocting liquid, add total medicine for the second time in medicinal residues
The water of 9 times of weight of material, decocts 1.5 hours, takes decocting liquid twice and merges, filters, and being evaporated to relative density at 60 DEG C is
1.15g/ml concentrated solution.The mass percent concentration for adding 2-3 times of volume again toward concentrated solution is 80% ethanol solution,
Filter, collect concentrated solution；
(3) mix：
80g glycerol and 50g Propylene Glycol, mix homogeneously are added in concentrated solution；Semen Cucurbitae oil and cedar wood alcohol are eventually adding, are stirred
Dissolving is mixed, mix homogeneously obtains final product medicinal liquid.
The preparation of 3 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight：
Herba Ecliptae 60g, Radix Polygoni Multiflori 30g, Folium Mori 50g, Cacumen Platycladi 40g, Radix Salviae Miltiorrhizae 50g, cedar wood alcohol 20g, Caulis Trachelospermi 30g, life
Rhizoma Zingiberis Recens 25g, Flos Genkwa 10g and Semen Cucurbitae oil 5g；
(2) extract：
Herba Ecliptae, Radix Polygoni Multiflori, Folium Mori, Cacumen Platycladi, Radix Salviae Miltiorrhizae, Caulis Trachelospermi, Rhizoma Zingiberis Recenss, Flos Genkwa are put in extraction pot, is added water to cook
Twice, the water of 8 times of weight of total medical material is added for the first time, is decocted 1.5 hours, is taken decocting liquid, add total medicine for the second time in medicinal residues
The water of 8 times of weight of material, decocts 1 hour, takes decocting liquid twice and merges, filters, and being evaporated to relative density at 60 DEG C is
1.20g/ml concentrated solution.The mass percent concentration for adding 2-3 times of volume again toward concentrated solution is 70% ethanol solution,
Filter, collect concentrated solution；
(3) mix：
120g PEG400s, mix homogeneously are added in concentrated solution；Semen Cucurbitae oil and cedar wood alcohol are eventually adding, are stirred
Dissolving, mix homogeneously obtain final product medicinal liquid.
The preparation of 4 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight：
Herba Ecliptae 70g, Radix Polygoni Multiflori 60g, Folium Mori 60g, Cacumen Platycladi 50g, Radix Salviae Miltiorrhizae 80g, cedar wood alcohol 40g, Caulis Trachelospermi 30g, life
Rhizoma Zingiberis Recens 30g, Flos Genkwa 20g and Semen Cucurbitae oil 6g；
(2) extract：
Herba Ecliptae, Radix Polygoni Multiflori, Folium Mori, Cacumen Platycladi, Radix Salviae Miltiorrhizae, Caulis Trachelospermi, Rhizoma Zingiberis Recenss, Flos Genkwa are put in extraction pot, is added water to cook
Twice, the water of 10 times of weight of total medical material is added for the first time, is decocted 2 hours, is taken decocting liquid, add total medical material for the second time in medicinal residues
The water of 10 times of weight, decocts 2 hours, takes decocting liquid twice and merges, filters, and it is 1.30g/ at 60 DEG C to be evaporated to relative density
The concentrated solution of ml.The mass percent concentration for adding 2-3 times of volume again toward concentrated solution is 80% ethanol solution, is filtered,
Collect concentrated solution；
(3) mix：
The PEG400 of 100g, mix homogeneously are added in concentrated solution；Semen Cucurbitae oil and cedar wood alcohol are eventually adding, are stirred
Dissolving is mixed, mix homogeneously obtains final product medicinal liquid.
The preparation of 5 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight：
Herba Ecliptae 100g, Radix Polygoni Multiflori 40g, Folium Mori 80g, Cacumen Platycladi 40g, Radix Salviae Miltiorrhizae 60g, cedar wood alcohol 80g, Caulis Trachelospermi 50g, life
Rhizoma Zingiberis Recens 40g, Flos Genkwa 15g and Semen Cucurbitae oil 10g；
(2) extract：
Herba Ecliptae, Radix Polygoni Multiflori, Folium Mori, Cacumen Platycladi, Radix Salviae Miltiorrhizae, Caulis Trachelospermi, Rhizoma Zingiberis Recenss, Flos Genkwa are put in extraction pot, is added water to cook
Twice, the water of 9 times of weight of total medical material is added for the first time, is decocted 2 hours, is taken decocting liquid, filtered, add for the second time total in medicinal residues
The water of 9 times of weight of medical material, decocts 2 hours, takes decocting liquid twice and merges, filters, and being evaporated to relative density at 60 DEG C is
1.20g/ml concentrated solution.The mass percent concentration for adding 2-3 times of volume again toward concentrated solution is 75% ethanol solution,
Filter, collect concentrated solution；
(3) mix：
The hyaluronic acid of 80g, mix homogeneously are added in concentrated solution；Semen Cucurbitae oil and cedar wood alcohol are eventually adding, are stirred molten
Solution, mix homogeneously obtain final product medicinal liquid.
The preparation of 6 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight：
Herba Ecliptae 90g, Radix Polygoni Multiflori 45g, Folium Mori 75g, Cacumen Platycladi 45g, Radix Salviae Miltiorrhizae 75g, cedar wood alcohol 65g and Semen Cucurbitae oil
7g；
(2) extract：
Herba Ecliptae, Radix Polygoni Multiflori, Folium Mori, Cacumen Platycladi, Radix Salviae Miltiorrhizae are put in extraction pot, is added water to cook twice, add for the first time total
The water of 10 times of weight of medical material, decocts 2 hours, takes decocting liquid, adds the water of 8 times of weight of total medical material for the second time in medicinal residues, decocts
1.5 hours, take decocting liquid twice and merge, filter, be evaporated to concentrated solution of the relative density at 60 DEG C for 1.10g/ml.It is past again
The mass percent concentration that 2-3 times of volume is added in concentrated solution is 75% ethanol solution, is filtered, and collects concentrated solution；
(4) mix：
The glycerol and 50g pyrrolidone sodium carboxylates of 60g, mix homogeneously are added in concentrated solution；Be eventually adding cedar wood alcohol and
Semen Cucurbitae oil, stirring and dissolving, mix homogeneously obtain final product medicinal liquid.
The preparation of 7 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight：
Herba Ecliptae 70g, Radix Polygoni Multiflori 60g, Folium Mori 60g, Cacumen Platycladi 50g, Radix Salviae Miltiorrhizae 80g, cedar wood alcohol 40g and Semen Cucurbitae oil
6g；
(2) extract：
Herba Ecliptae, Radix Polygoni Multiflori, Folium Mori, Cacumen Platycladi, Radix Salviae Miltiorrhizae are put in extraction pot, is added water to cook twice, add for the first time total
The water of 9 times of weight of medical material, decocts 2 hours, takes decocting liquid, adds the water of 8 times of weight of total medical material for the second time in medicinal residues, decocts
1.5 hours, take decocting liquid twice and merge, filter, be evaporated to concentrated solution of the relative density at 60 DEG C for 1.15g/ml.It is past again
The mass percent concentration that 2-3 times of volume is added in concentrated solution is 75% ethanol solution, is filtered, and collects concentrated solution；
(4) mix：
70g PEG400s and 50g chitins, mix homogeneously are added in concentrated solution；It is eventually adding cedar wood alcohol and Fructus Cucurbitae moschatae
Seed oil, stirring and dissolving, mix homogeneously obtain final product medicinal liquid.
The preparation of 8 externally-applied medicinal composition of embodiment
(1) each material composition is weighed by following weight：
Herba Ecliptae 100g, Radix Polygoni Multiflori 40g, Folium Mori 80g, Cacumen Platycladi 40g, Radix Salviae Miltiorrhizae 60g, cedar wood alcohol 80g and Semen Cucurbitae oil
10g；
(2) extract：
Herba Ecliptae, Radix Polygoni Multiflori, Folium Mori, Cacumen Platycladi, Radix Salviae Miltiorrhizae are put in extraction pot, is added water to cook twice, add for the first time total
The water of 8 times of weight of medical material, decocts 1.5 hours, takes decocting liquid, adds the water of 8 times of weight of total medical material for the second time in medicinal residues, decocts
1 hour, take decocting liquid twice and merge, filter, be evaporated to concentrated solution of the relative density at 60 DEG C for 1.20g/ml.Again toward dense
The mass percent concentration that 2-3 times of volume is added in contracting liquid is 80% ethanol solution, is filtered, and collects concentrated solution；
(3) mix：
60g glycerol and 50g hyaluronic acids, mix homogeneously are added in concentrated solution；Cedar wood alcohol and Semen Cucurbitae oil are eventually adding,
Stirring and dissolving, mix homogeneously obtain final product medicinal liquid.
Pharmacodynamics test of the pharmaceutical composition of 1 present invention of experimental example to mouse hair growth
Experiment material：Anthology inventive embodiments 1, embodiment 2, embodiment 3, the externally-applied medicinal composition of embodiment 6；101
Hair-loss preventing and hair-restoring agent (Beijing Zhangguang 101 Technology Co., Ltd., product batch number：20120301)；Distilled water.
60 inbred mouses are taken, cleaning grade, female, 6-7 week old, body weight 18-20g are numbered by body weight, be divided into 6 groups, adopt
It is divided into 1 group of pharmaceutical composition embodiment, 2 groups of embodiment, 3 groups of embodiment, 6 groups of embodiment, positive control with random alignment table method
Group (smearing 101 hair-loss preventing and hair-restoring agent), blank control group (smearing distilled water), 10 per group.Mice Jing after etherization with Colophonium/
Mineral wax mixture (1: 1) heat is applied to back after melting, it is to be solidified be hardened after throw off, it is smooth with mouse back, without wound without Rhizoma Imperatae be
Only, its hair is induced to enter trophophase by resting stage, lose hair or feathers area about 2cm × 2cm.Respectively at hair removal section from the 2nd day after depilation
Relative medicine is smeared, 2 times a day, each 0.2mL/, Continuous Observation 30 days.
1st, mice epilation position goes out the situation of change of mao time
From after coating the 2nd day, the change for observing the daily color of mouse back epilation area skin determined the growth of hair follicle
State and naked eyes observation hair removal section hair growth situation directly perceived, record every mice and go hair-fields skin color to be become by pink
Time of Lycoperdon polymorphum Vitt, Lycoperdon polymorphum Vitt are to growing mao time and cover with the time of hair.
As shown in table 1, after mice depilation, skin is presented pink to experimental result, and hair enters resting stage, 6～7d of coating
1 group of embodiment starts blackening afterwards, and after 6～8d, 2 groups of embodiment starts blackening, after 7～9d, 3 groups of embodiment, 6 groups of embodiment and sun
Property matched group skin start black, after 13～15d, blank group starts blackening.There is significance between each group and blank control group
There is significant difference (P with positive controls in difference, wherein 1 group of embodiment, 2 groups of embodiment<0.05)；After 13～14d of coating
2 groups of dark skin of 1 group of embodiment and embodiment start change and grow hair, after 14～16d, 3 groups of embodiment, 6 groups of embodiment and sun
Property matched group dark skin starts to grow hair, and after 19～20d, blank group starts to grow hair.Each group is equal with blank control group
There is significant difference, 1 group of embodiment, 2 groups of embodiment have significant difference (P with positive controls<0.05), 3 groups of embodiment,
There was no significant difference and positive controls between for 6 groups of embodiment；After 26～30d of administration, positive controls and embodiment each group are equal
Hair is covered with, and 1 group of embodiment has pole significant difference (P with positive controls<0.01), 2 groups of embodiment and positive control
Group there is also significant difference (P<0.05).
1 each group mouse back of table epilation area's skin color transformation period compares (x ± s, n=10)
| Group | Skin is pink to the graying time | Ashen skin grows a mao time | Skin covers with a mao time |
| Blank control group | 14.86±1.36 | 20.02±0.56 | 30.16±0.91 |
| 1 group of embodiment | 7.25±0.34* | 14.23±0.96* | 27.19±0.32** |
| 2 groups of embodiment | 7.86±1.03* | 14.98±1.06* | 27.56±0.35* |
| 3 groups of embodiment | 8.51±0.96 | 15.65±0.75 | 28.21±0.36 |
| 6 groups of embodiment | 8.65±1.12 | 15.32±1.03 | 28.16±1.32 |
| Positive controls | 8.43±0.84 | 15.23±0.89 | 28.94±0.35 |
Note：Compare with positive controls matched group, * P ＜ 0.05, * * P<0.01.
2nd, to mouse neonatal hair length and the situation of change of weight
Experiment last day, de- cervical vertebra put to death mice, takes in every mice bilateral hair removal section antimere and most become mildewed 3, swims
Mark kind of calliper length, and meansigma methodss are calculated, as each mice hair removal section new life hair length；Take test block hair removal section skin simultaneously
Skin (4cm2), formed objects skin graft is laid with card punch, whole hairs is removed on skin graft and is weighed, as each mouse neonatal hair
Weight.
Experimental result is as shown in table 2,1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 6 groups of embodiment and positive controls
The newborn staple length of mice and weight are more blank to be significantly increased, and there is pole significance with blank control group poor between each group
Not, there is difference (P in the newborn staple length and weight of wherein 2 groups of 1 group of embodiment and embodiment with positive controls<
0.05)。
The comparison (x ± s, n=10) of 2 each group mouse back of table new life hair length and weight
| Group | Newborn hair length (mm) | New piliation weight (mg) |
| Blank control group | 4.12±0.74 | 2.11±0.14 |
| 1 group of embodiment | 8.73±0.75* | 4.77±0.86* |
| 2 groups of embodiment | 8.51±1.11* | 4.36±0.21* |
| 3 groups of embodiment | 7.14±0.46 | 3.89±0.25 |
| 6 groups of embodiment | 7.58±0.73 | 3.13±0.47 |
| Positive controls | 7.42±0.48 | 3.44±0.35 |
Note：Compare with positive controls matched group, * P ＜ 0.05.
3rd, each group mouse back skin major histological situation of change
Experiment last day, de- cervical vertebra put to death mice, by every mice hair removal section skin (4cm2) gross weight removes, take wherein
Ten pin hair film-makings, microphotograph simultaneously observe the change of hair follicle.Finally by the skin histology of test block, fixed with 10% formaldehyde,
Along hair follicle longitudinal direction tangent plane tissue, conventional organization dehydration, paraffin embedding are carried out, mouse skin group is observed in HE dyeing, light microscopic microscopy
Knit.Observation item includes：(1) high dermis blood vessels caliber (um), (2) high dermis blood vessel number (individual), with 200 times of visual field sizes
(3) high dermis hair follicles outgrowth number (individual) are counted, with the big subtotal figure in 100 times of visuals field.
Experimental result is as shown in table 3,1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 6 groups of embodiment and positive controls
High dermis hair follicles outgrowth number, high dermis blood vessel number, high dermis blood vessels caliber to mouse skin is compared with blank control group
There is difference, the wherein high dermis hair follicles outgrowth number of 1 group of mouse skin of embodiment, high dermis blood vessel number, corium is shallow
Layer blood vessels caliber has pole difference (P ＜ 0.01) with positive controls, and the high dermis of 2 groups of mouse skins of embodiment are newborn
Hair follicle number, high dermis blood vessel number, high dermis blood vessels caliber and positive controls have difference (P ＜ 0.05).
3 each group mouse back skin major histological of table changes (x ± s, n=10)
Note：Compare with positive controls matched group, * P ＜ 0.05, * * P ＜ 0.01.
Summary three test result indicate that, the present invention provide pharmaceutical composition can be effectively promoted the new old of scalp
Metabolic function and hair root nutrients absorb, and reach the purpose of effectively treatment alopecia, by mice high dermis hair follicle number, blood capillary
Test with blood vessels caliber, more it can be seen that the pharmaceutical composition of the present invention can increase local amount of blood supply, improve local microcirculation,
Strengthen hair follicle nutrition, promote hair growth and regeneration, grown come hair follicle stimulating by blood circulation promoting and blood stasis dispelling, more general product for improving hair-growing is more
The regeneration of hair can be excited, hair growth is finally reached, is promoted the therapeutic effect of hair growth promoting, and cheap, production technology
Simply, it is adapted to Clinical practice and large-scale production.
Claims (10)
1. it is a kind of for hair growth, the externally-applied medicinal composition of promotion hair growth promoting, it is characterised in that by the original of following parts by weight
Material medicine is made：Herba Ecliptae 60-120 parts, Radix Polygoni Multiflori 30-60 parts, Folium Mori 50-100 parts, Cacumen Platycladi 30-60 parts, Radix Salviae Miltiorrhizae 50-100
Part, cedar wood alcohol 20-110 parts and Semen Cucurbitae oil 5-10 parts.
2. externally-applied medicinal composition according to claim 1, it is characterised in that by the crude drug system of following parts by weight
Into：Herba Ecliptae 80-100 parts, Radix Polygoni Multiflori 40-50 parts, Folium Mori 60-90 parts, Cacumen Platycladi 30-60 parts, Radix Salviae Miltiorrhizae 60-90 parts, cedar wood alcohol
40-90 parts and Semen Cucurbitae oil 5-10 parts.
3. externally-applied medicinal composition according to claim 2, it is characterised in that by the crude drug system of following parts by weight
Into：90 parts of Herba Ecliptae, 45 parts of Radix Polygoni Multiflori, 75 parts of Folium Mori, 45 parts of Cacumen Platycladi, 75 parts of Radix Salviae Miltiorrhizae, 65 parts of cedar wood alcohol and Semen Cucurbitae oil 7
Part.
4. it is a kind of for hair growth, the externally-applied medicinal composition of promotion hair growth promoting, it is characterised in that by the original of following parts by weight
Material medicine is made：Herba Ecliptae 60-120 parts, Radix Polygoni Multiflori 30-60 parts, Folium Mori 50-100 parts, Cacumen Platycladi 30-60 parts, Radix Salviae Miltiorrhizae 50-100
Part, cedar wood alcohol 20-110 parts, Caulis Trachelospermi 30-50 parts, Rhizoma Zingiberis Recenss 25-55 parts, Flos Genkwa 10-20 parts and Semen Cucurbitae oil 5-10 parts.
5. externally-applied medicinal composition according to claim 4, it is characterised in that by the crude drug system of following parts by weight
Into：Herba Ecliptae 80-100 parts, Radix Polygoni Multiflori 40-50 parts, Folium Mori 60-90 parts, Cacumen Platycladi 30-60 parts, Radix Salviae Miltiorrhizae 60-90 parts, cedar wood alcohol
40-90 parts, Caulis Trachelospermi 35-45 parts, Rhizoma Zingiberis Recenss 30-45 parts, Flos Genkwa 10-15 parts and Semen Cucurbitae oil 5-10 parts.
6. externally-applied medicinal composition according to claim 5, it is characterised in that by the crude drug system of following parts by weight
Into：90 parts of Herba Ecliptae, 45 parts of Radix Polygoni Multiflori, 75 parts of Folium Mori, 45 parts of Cacumen Platycladi, 75 parts of Radix Salviae Miltiorrhizae, 65 parts of cedar wood alcohol, 40 parts of Caulis Trachelospermi,
7 parts of 40 parts of Rhizoma Zingiberis Recenss, 15 parts of Flos Genkwa and Semen Cucurbitae oil.
7. a kind of method for preparing the externally-applied medicinal composition described in claim 1-6 any one of item, it is characterised in that the system
Preparation Method is comprised the following steps：
(1) parts by weight as described in any one of claim 1-6 weigh each crude drug；
(2) extract：
Other crude drug in addition to Semen Cucurbitae oil and cedar wood alcohol are put in extraction pot, is added water to cook twice, add for the first time total
The water of 8-10 times of weight of medical material, decocts 1-2 hours, takes decocting liquid, adds total 8-10 times of weight of medical material for the second time in medicinal residues
Water, decocts 1-2 hours, takes decocting liquid twice and merges, filters, and it is 1.10～1.30g/ml at 60 DEG C to be evaporated to relative density
Concentrated solution, then in concentrated solution add 2-3 times of volume ethanol solution, filter, collect concentrated solution；
(3) mix：
The wetting agent of 50-120 weight portions, mix homogeneously are added to concentrated solution；Semen Cucurbitae oil and cedar wood alcohol are eventually adding, are stirred molten
Solution, mix homogeneously obtain final product described externally-applied medicinal composition.
8. preparation method according to claim 7, it is characterised in that the quality percentage of ethanol solution described in step (2)
Specific concentration is 70%-80%.
9. preparation method according to claim 7, it is characterised in that the wetting agent described in step (3) is selected from glycerol, poly-
One or more combination in ethylene glycol, Propylene Glycol, chitin, hyaluronic acid and pyrrolidone sodium carboxylate.
10. the externally-applied medicinal composition described in any one of claim 1-6 is in the external used medicine for preparing hair growth, promote hair growth promoting
In purposes.
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| CN107890556A (en) * | 2017-12-04 | 2018-04-10 | 张致恒 | A kind of Traditional Chinese medicine tincture preparation of hair growth and preparation method thereof |
| CN111265592A (en) * | 2019-12-31 | 2020-06-12 | 云南素颜素心生物科技有限公司 | Agent for hair or scalp and method for producing the same |
| CN111867580A (en) * | 2018-01-18 | 2020-10-30 | （株）娜迪安生物公司 | Composition for preventing or improving hair loss comprising dungeon as an effective ingredient |
| CN112206249A (en) * | 2020-10-13 | 2021-01-12 | 安徽大学 | Medicine for treating female alopecia and preparation method thereof |
| CN113730452A (en) * | 2021-10-12 | 2021-12-03 | 遵义医科大学 | Application of eclipta petroleum ether extract in preparation of preparation for preventing and/or treating chemotherapy-induced alopecia |
| CN115779028A (en) * | 2022-08-30 | 2023-03-14 | 北京博奥晶方生物科技有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
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| CN111265592A (en) * | 2019-12-31 | 2020-06-12 | 云南素颜素心生物科技有限公司 | Agent for hair or scalp and method for producing the same |
| CN112206249A (en) * | 2020-10-13 | 2021-01-12 | 安徽大学 | Medicine for treating female alopecia and preparation method thereof |
| CN113730452A (en) * | 2021-10-12 | 2021-12-03 | 遵义医科大学 | Application of eclipta petroleum ether extract in preparation of preparation for preventing and/or treating chemotherapy-induced alopecia |
| CN115779028A (en) * | 2022-08-30 | 2023-03-14 | 北京博奥晶方生物科技有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN115779028B (en) * | 2022-08-30 | 2024-05-07 | 北京博奥晶方生物科技有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
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