CN103356807A - Drug composite with function of enhancing immunity and preparation method thereof - Google Patents
Drug composite with function of enhancing immunity and preparation method thereof Download PDFInfo
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- CN103356807A CN103356807A CN2012100914136A CN201210091413A CN103356807A CN 103356807 A CN103356807 A CN 103356807A CN 2012100914136 A CN2012100914136 A CN 2012100914136A CN 201210091413 A CN201210091413 A CN 201210091413A CN 103356807 A CN103356807 A CN 103356807A
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Abstract
The invention discloses a drug composite with the function of enhancing immunity and a preparation method thereof. The drug composite is prepared from ginseng, medlar, acanthopanax senticosus, poria cocos and radix astragali preparata which are in a certain weight ratio; and the drug composite can be prepared into any one common formulation and preferably prepared into an oral formulation. The drug composite disclosed by the invention has the function of enhancing the immunity of an organism.
Description
Technical field
The present invention relates to a kind of composition and method of making the same with enhancing immunity function, belong to the technical field of health food.
Background technology
Immune system is the defence network that covers whole body, the first line of defence of protection health.Immune system (immunologicfunction) is the protection capability that living organism progressively obtains in phyletic evolution and ontogenetic process.Mainly comprise three aspects: body is resisted the immune protection function of extraneous infectious; Body is removed damage and dead cell, keeps self physiological equilibrium's homeostatic function; Body is monitored, find and remove the immune surveillance function of mutant cell.Under normal physiological conditions, the immune system of body relies on its congenital immunocompetence that has and the effect of acquired immunocompetence performance co-immunization, keeps the physiological function of body relatively stable.If the immunologic function abnormal will inevitably cause the imbalance of body physiological function, change thereby pathologic occurs.And theory of Chinese medical science thinks that all paathogenic factors are pathogen, and all resistances against diseases are healthy energy.Healthy energy is divided into again qi of zang-fu viscera of defending gas, vigour and Main Tissues organ etc.It is can play the defence exopathogen to invade the healthy energy of human body that what is called is defended gas.If healthy energy is vigorous, body just can eliminating evil going out, avoid sick, i.e. so-called " healthy energy internal memory, heresy can not be done ".If the positive deficiency of vital energy declines, then pathogen is invaded body easily and is caused disease, and namely so-called causing a disease is because " institute of heresy beats, and its gas must be empty ".Therefore the basic principle of strengthening vital QI to eliminate pathogenic factors to consolidate that propose in the process of preventing and curing diseases of the traditional Chinese medical science is consistent with the health-care method of enhancing human body immunity power.
Summary of the invention
The object of the invention has provided a kind of compositions with enhancing immunity.
Another object of the present invention has provided the preparation method of said composition.
The present invention is achieved by the following technical solutions:
The present invention is made by the raw material of following weight parts:
Radix Panacis Quinquefolii 1-25 part, Fructus Lycii 1-20 part, Radix Et Caulis Acanthopanacis Senticosi 1-15 part, Poria 1-20 part, Radix Astragali Preparata 1-20 part.
Be preferably:
Radix Panacis Quinquefolii 5-15 part, Fructus Lycii 3-10 part, Radix Et Caulis Acanthopanacis Senticosi 3-8 part, Poria 3-10 part, Radix Astragali Preparata 3-10 part.
More preferably:
Radix Panacis Quinquefolii 8-10 part, Fructus Lycii 5-8 part, Radix Et Caulis Acanthopanacis Senticosi 4-6 part, Poria 5-8 part, Radix Astragali Preparata 5-8 part.
The mechanism of action of each component is as follows among the present invention:
Radix Panacis Quinquefolii: being medicinal and edible plant, is famous and precious top grade Chinese medicine, is again the high-grade nourishing good merchantable brand.Has YIN nourishing and QI supplementing, the double effects that the mind calming and mentality promoting and clearing away heat and promoting production of body fluid, pathogenic fire reducing are relieved summer heat.The archaism cloud: " Radix Panacis Quinquefolii is cool in nature and mend, all wishs be not subjected to Radix Ginseng the warm person of Radix Ginseng all available it ".Not dry so mend is the special feature of Radix Panacis Quinquefolii.It contains 16 kinds of trace element of needed by human and 17 kinds with upper amino acid and polysaccharide, polypeptide and multivitamin etc., has anticancer, resisting fatigue, anti-hypoxia, radioprotective, the anti-ageing several functions of waiting for a long time.Its Main Function has: the mobility of strengthening cardiac muscle and enhancing heart; Strong nervus centralis, stable body and mind also sets up, and calmness and antialcoholism action are arranged, and the hypermnesis ability has remarkable efficacy to the Alzheimer; Blood pressure there is Accommodation, makes temporary or the persistency blood pressure drops; Suppress arteriosclerosis and promote Growth of red blood cells, increase the deal of hematochrome; Can regulate the secretion of islets of langerhans, therefore powerful to diabetes; Liver there are the secretion of regulating the accessory suprarenal glands element, the effect that enhances metabolism; Can physical strength reinforcing and athlete's tool greatly benefited; The anticancer growth increases immunologic function; Encourage digestion, to chronic gastropathy and the weak effect that helps of the intestines and stomach.
Fructus Lycii: be the mature fruit of matrimony vine of solanaceae plant, it has consequence in the traditional medicine of motherland, and its medical value enjoys the high praise of ancient Chinese medicine doctor.Put down in writing in the Compendium of Material Medica: " nourishing the liver makes eye bright for Fructus Lycii, kidney-tonifying sperm-generating, hard muscles and bones, and fatigue taking away, easily color bleaches, and makes eye bright and calms the nerves, and makes us long-lived." eat for a long time Fructus Lycii, the effects such as treatment body constitution deficiency and coldness, hyposexuality, constipation, insomnia, hypotension, anemia, alopecia and skin protection are arranged.The traditional Chinese medical science has the saying of " medlar health preserving " very early, think it can nourishing the liver and kidney, replenishing vital essence to improve eyesight, nourish blood, strengthen people's immunity, often eating Fructus Lycii can " hard muscles and bones, old, the cold-resistant summer-heat of making light of one's life by commiting suicide ".Modern study also shows, it has enhancing immunity, slow down aging, the effect such as anticancer, so it usually is taken as nourishing and takes good care of and antidotal good medicine.
Radix Et Caulis Acanthopanacis Senticosi: the root bark for Araliaceae Radix Et Caulis Acanthopanacis Senticosi and five stalk slender acanthopanaxs, see Shennong's Herbal, classify as top grade.Acrid in the mouth, little hardship, slightly warm in nature.Return spleen, kidney, heart channel.Has wind-damp dispelling; Invigorating the liver and kidney; Bone and muscle strengthening; The invigorate blood circulation effect of arteries and veins.Radix Et Caulis Acanthopanacis Senticosi polysaccharide (PES.) and glycoside B (ligustrin), D and E (the syringaresinol glycosides of two kinds of configurations) all can obviously improve the ability that cell produces inducement interferon, with PES (sterling) the best, PES and glycoside B, D, E take second place to the short ability of inducing of S801 and S7811 Leukemia Cell Lines.Op Radix Et Caulis Acanthopanacis Senticosi (50g/kg) has protective effect to the leukopenia that the subcutaneous injection cyclophosphamide causes, the mice that benzene is caused and the leukopenia of rabbit also have significant preventive effect.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.The property slightly sweet flavor flat, enter the heart, lung, spleen channel.Has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can control dysuria, the edema distension, the phlegm retention cough with dyspnea, vomiting, malignant histocytosis is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.Contain pachyman, glucose, protein, aminoacid, organic acid, fat, lecithin, adenine, choline, ergosterol, plurality of enzymes and potassium salt.Energy enhancing human body immunity function, pachyman has obvious antitumor action; Diuresis is arranged, can increase the electrolytical discharges such as potassium, sodium, chlorine in the urine; The effect such as generation, blood sugar lowering, anti-radiation of calmness and the liver protecting, inhibition ulcer is arranged.
The Radix Astragali: Chinese medicine thinks that the Radix Astragali has the effect of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, expelling pus and toxin by strengthening QI, inducing diuresis to remove edema, expelling pus and promoting granulation.Modern pharmacological research shows, contain the various bioactivators such as polysaccharide, protein, alkaloid, aminoacid, flavonoid, glycoside, trace element in the Radix Astragali, has the enhancing human body immunity function, the effects such as heart tonifying blood pressure lowering, blood sugar lowering, diuresis, defying age, resisting fatigue, antitumor, antiviral, calmness, analgesia.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the preparation of any routine, comprises oral formulations, external preparation, injection.For example can be with these crude drug pulverize mix homogeneously; The ethanol extraction that the crude drug of described weight portion can be added respectively water or variable concentrations, the extracting solution concentrate drying gets crude extract, or employing process for purification, for example, decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation are made with extra care and are obtained extract.
When stating medicine in the use, the medicine that both can adopt to be equivalent to described weight proportion is that raw material cleans respectively, and is dry, pulverize, be mixed to get the granule or the powder that meet preparation requirement granularity and directly take.The medicine that also can adopt to be equivalent to described weight proportion relation is that raw material adds pharmaceutic adjuvant after suitably processing, and is made into as required various preparations.Be prepared into by the above-mentioned raw materials medicine in the process of preparation, the above-mentioned raw materials medicine can adopt following method to process: add respectively the ethanol extraction of water or variable concentrations, the extracting solution concentrate drying gets crude extract; Or further adopt alcohol deposition method, water back dissolution method, organic solvent extractionprocess, flocculent precipitation, column chromatography one or more unite and use after suitably making with extra care to get extract; Adoptable concrete operations and/or using method when above-mentioned effective medicinal ingredient is extracted, both can be that ingredient take described each proportional quantities is as raw material, extract respectively decomposite mode behind its effective medicinal ingredient, also can adopt each medicine material by said proportional quantities to mix after the common mode of extracting again.Adopt different extraction means, equipment and actual conditionses such as required desirable or best extraction temperature, solvent load, extraction time, extraction time when extracting, then can be according to practical situation by testing screened and finding.
Better bring into play drug effect for each raw material that makes this medicine, preferably the raw material of proportioning of the present invention carried out alcohol extraction, but can not be used for restriction protection scope of the present invention.
The preparation method of the present composition is as follows:
Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, Radix Astragali Preparata with described proportioning add ethanol and extract, and extracting solution merges, and filter, and filtrate is concentrated into thick paste, and drying under reduced pressure is ground into fine powder, namely gets the active component of medicine of the present invention.
The preparation method of the present composition is preferably:
With Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 6-12 and doubly measure the 50-95% ethanol extraction 1-4 time, each 1-3 hour, extracting solution merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, namely gets the active component of medicine of the present invention.
The preparation method of the present composition can also for:
With Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 6-12 times of water gaging and extract 1-4 time, each 1-3 hour, extracting solution merges, and filters, and filtrate is concentrated into thick paste, drying is ground into fine powder, namely gets the active component of medicine of the present invention.
The active constituents of medicine of the present invention that makes can directly be used as medicine take or add on the pharmaceutics acceptable adjuvant routinely technique be prepared into required preparation.As making the oral drugs of the solid preparation forms such as tablet commonly used (dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, effervescent tablet), capsule (hard capsule, soft capsule), granule, pill (drop pill), powder, also can make the oral drugs of the liquid preparation forms such as syrup, oral liquid; Can also make the external used medicine of the external preparation forms such as unguentum, gel, ointment, cataplasma, emplastrum, liniment, lotion, liniment.Therefore, except effective ingredient, can also contain pharmaceutically acceptable adjuvant in this pharmaceutical composition.
Adjuvant described here can be different according to different preparations, such as diluent commonly used in the solid preparations such as tablet, capsule, granule, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler etc.; The surfactant of in the liquid preparation forms such as syrup, oral liquid, commonly using, diluent, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc.; The medicinal oleaginous base of in the external preparation forms such as gel, ointment, commonly using, aqueous matrix, antiseptic, antioxidant, wetting agent, Percutaneous absorption enhancer, surfactant etc.
Its adjuvant commonly used such as starch, lactose, dextrin, Icing Sugar, microcrystalline Cellulose, mannitol, xylitol, Polyethylene Glycol, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, modified starch, sorbitol, polyvidon, Heavy Magnesium Carbonate, sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, methylcellulose, ethyl cellulose, carboxymethylstach sodium, hydroxypropyl cellulose, PVP K30, kaolin, pregelatinized Starch, magnesium stearate, Pulvis Talci, micropowder silica gel, stevioside, betanin, aspartame, glycyrrhizin, saccharin sodium, citric acid, sodium bicarbonate, sodium carbonate, carrageenan, agar, gelatin, sodium alginate, xanthan gum, guar gum, tragcanth, arabic gum, locust bean gum, POLY-karaya, stearic acid, glyceryl monostearate, polyacrylamide, cross linked sodium polyacrylate, polyvinyl alcohol, carbomer, sorbic acid, potassium sorbate, ethyl hydroxybenzoate, benzyl alcohol, nipalgin, thimerosal, dimethyl sulfoxide, azone, triethanolamine, sodium hydroxide, glycerol, propylene glycol, BHT, BHA, sodium lauryl sulphate, Tweens, spans etc.
For preparation above-mentioned, preferred particulates agent of the present invention, preparation method is as follows:
With Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 8 times of amount 70% ethanol extractions 3 times, each 1.5 hours, extracting solution merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure, be ground into fine powder, add appropriate amount of auxiliary materials, mixing, with 85% alcohol granulation, drying, granulate, and get final product.
The present invention relates to a kind of compositions for enhancing human body immunity power, is a kind of nutrient substance that has no side effect of pure natural, is different from the like product of being made by chemical constituent.
The specific embodiment
Embodiment 1:
Radix Panacis Quinquefolii 90g, Fructus Lycii 60g, Radix Et Caulis Acanthopanacis Senticosi 50g, Poria 60g, Radix Astragali Preparata 70g.
Take by weighing Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 8 times of amount 70% ethanol extractions 3 times, each 1.5 hours, extracting solution merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, adds sucrose, aspartame, dextrin is an amount of, mixing is with 85% alcohol granulation, drying, granulate namely gets granule.
Embodiment 2:
Radix Panacis Quinquefolii 10g, Fructus Lycii 200g, Radix Et Caulis Acanthopanacis Senticosi 10g, Poria 200g, Radix Astragali Preparata 10g
Take by weighing Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 12 times of amount 50% ethanol extractions 2 times, each 2 hours, extracting solution merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure, be ground into fine powder, add lactose, mannitol is an amount of, mixing, with 85% alcohol granulation, drying, granulate namely gets granule.
Embodiment 3:
Radix Panacis Quinquefolii 250g, Fructus Lycii 10g, Radix Et Caulis Acanthopanacis Senticosi 150g, Poria 10g, Radix Astragali Preparata 200g
Take by weighing Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 6 times of amount 95% ethanol extractions 4 times, each 1 hour, extracting solution merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure, be ground into fine powder, add microcrystalline Cellulose, lactose is an amount of, mixing, granulate, drying, granulate namely gets granule.
Embodiment 4:
Radix Panacis Quinquefolii 50g, Fructus Lycii 100g, Radix Et Caulis Acanthopanacis Senticosi 30g, Poria 100g, Radix Astragali Preparata 30g
Take by weighing Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 10 times of amount 80% ethanol extractions 3 times, each 1 hour, extracting solution merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, and carboxymethyl starch sodium, micropowder silica gel, microcrystalline Cellulose, polyvinylpolypyrrolidone are an amount of, mixing is granulated drying, add magnesium stearate, mixing, tabletting, coating or coating not namely get tablet.
Embodiment 5:
Radix Panacis Quinquefolii 150g, Fructus Lycii 30g, Radix Et Caulis Acanthopanacis Senticosi 80g, Poria 30g, Radix Astragali Preparata 100g
Take by weighing Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 7 times of amount 60% ethanol extractions 1 time, each 3 hours, extracting liquid filtering, decompression recycling ethanol is to thick paste, and drying under reduced pressure is ground into fine powder, add appropriate amount of auxiliary materials, mixing is granulated drying, encapsulated, namely get capsule.
Embodiment 6:
Radix Panacis Quinquefolii 120g, Fructus Lycii 100g, Radix Et Caulis Acanthopanacis Senticosi 80g, Poria 90g, Radix Astragali Preparata 50g
Take by weighing Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 8 times of water gagings and extract 3 times, each 2 hours, extracting liquid filtering was concentrated into thick paste, and drying under reduced pressure is ground into fine powder, adds right amount of auxiliary materials, and mixing is made pill.
Embodiment 7:
Radix Panacis Quinquefolii 20g, Fructus Lycii 150g, Radix Et Caulis Acanthopanacis Senticosi 100g, Poria 120g, Radix Astragali Preparata 80g
Take by weighing Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 8 times of amount 60% ethanol extractions 3 times, each 2 hours, extracting liquid filtering, Recycled ethanol is to distinguishing the flavor of without alcohol, suitably concentrated, add an amount of suspensoid, flavoring agent, antiseptic, mixing, add the water standardize solution, filter, packing namely gets oral liquid.
Embodiment 8:
Radix Panacis Quinquefolii 70g, Fructus Lycii 110g, Radix Et Caulis Acanthopanacis Senticosi 110g, Poria 90g, Radix Astragali Preparata 100g
Take by weighing Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 12 times of water gagings and extract 2 times, each 3 hours, extracting liquid filtering was concentrated into thick paste, and drying under reduced pressure is ground into fine powder, makes powder.
Embodiment 9:
Radix Panacis Quinquefolii 30g, Fructus Lycii 40g, Radix Et Caulis Acanthopanacis Senticosi 80g, Poria 90g, Radix Astragali Preparata 90g
Take by weighing Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 10 times of water gagings and extract 1 time, each 3 hours, extracting liquid filtering, be concentrated into thick paste, drying under reduced pressure is ground into fine powder, adds appropriate amount of auxiliary materials, granulate, drying, granulate namely gets granule.
Further set forth the beneficial effect of compositions of the present invention by following experiment:
1, clinical data: choose 100 routine hypoimmunity patients for treatment target, male 48 people wherein, women 52 people, the age is 20-60 year, average 38.8 years old.
2, efficacy assessment standard
Produce effects: body constitution obviously strengthens, and extremity are strong, and is energetic, and face improves, and the aspect sub-health states such as sleep and digestion obviously improve;
Effectively: body constitution strengthens to some extent, and extremity are more favourable, and energy and face all take a turn for the better to some extent, and the sub-health state of the aspects such as sleep and digestion makes moderate progress;
Invalid: symptom and every inspection have no improvement.
3, Therapeutic Method: oral medicine of the present invention (being prepared by embodiment 1), every day, respectively once, 30 days was a course for the treatment of sooner or later.
4, therapeutic outcome: clinical observation result shows, wherein 85 routine immunocompromised persons take medicine of the present invention after 1 course for the treatment of, and body constitution obviously strengthens, and is energetic, is produce effects; 12 routine immunocompromised persons take medicine of the present invention after 1 course for the treatment of, and body constitution strengthens to some extent, and extremity are stronger, for effectively; 3 routine immunocompromised persons take medicine of the present invention after 1 course for the treatment of, and symptom is substantially without improving, for invalid.Total effective rate is 97%.
Claims (10)
1. the compositions with enhancing immunity function is characterized in that, it is to be made by the component of following weight portion: Radix Panacis Quinquefolii 1-25 part, Fructus Lycii 1-20 part, Radix Et Caulis Acanthopanacis Senticosi 1-15 part, Poria 1-20 part, Radix Astragali Preparata 1-20 part.
2. compositions according to claim 1 is characterized in that, it is to be made by the component of following weight portion: Radix Panacis Quinquefolii 5-15 part, Fructus Lycii 3-10 part, Radix Et Caulis Acanthopanacis Senticosi 3-8 part, Poria 3-10 part, Radix Astragali Preparata 3-10 part.
3. the preparation method of compositions according to claim 1 and 2 is characterized in that, it is like this preparation:
Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, Radix Astragali Preparata with described proportioning add ethanol and extract, and extracting solution merges, and filter, and filtrate is concentrated into thick paste, and drying under reduced pressure is ground into fine powder, namely gets the active component of medicine of the present invention.
4. the preparation method of compositions according to claim 3 is characterized in that, it is like this preparation:
With Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 6-12 and doubly measure the 50-95% ethanol extraction 1-4 time, each 1-3 hour, extracting solution merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure is ground into fine powder, namely gets the active component of medicine of the present invention.
5. according to claim 3 or the preparation method of 4 described compositionss, it is characterized in that, the medicine activity component that makes add or do not add adjuvant routinely technique make acceptable preparation on the pharmaceutics.
6. the preparation method of compositions according to claim 5 is characterized in that, described preparation is oral formulations.
7. the preparation of compositions according to claim 6 is characterized in that, described oral formulations refers to tablet, granule, capsule, pill, powder, oral liquid.
8. preparation according to claim 7 is characterized in that, described preparation is granule.
9. granule according to claim 8 is characterized in that, it is like this preparation:
With Radix Panacis Quinquefolii, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Poria, the Radix Astragali Preparata of described weight proportion, add 8 times of amount 70% ethanol extractions 3 times, each 1.5 hours, extracting solution merges, and filters, and decompression recycling ethanol is to thick paste, drying under reduced pressure, be ground into fine powder, add appropriate amount of auxiliary materials, mixing, with 85% alcohol granulation, drying, granulate, and get final product.
10. compositions according to claim 1 and 2 is used for the application at the health food of preparation enhancing immunity.
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| CN103609790A (en) * | 2013-10-31 | 2014-03-05 | 安徽博格生物科技有限公司 | Tea bag capable of enhancing immunization and preventing disease |
| CN103609788A (en) * | 2013-10-31 | 2014-03-05 | 安徽博格生物科技有限公司 | Tea bag capable of enriching yin and nourishing kidney as well as invigorating yang |
| CN103798473A (en) * | 2014-01-16 | 2014-05-21 | 戴明传 | Longevity healthcare tea |
| CN104547544A (en) * | 2014-12-26 | 2015-04-29 | 山东明仁福瑞达制药股份有限公司 | Health food composition improving immunity and eliminating chronic fatigue |
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| CN105616840A (en) * | 2016-02-22 | 2016-06-01 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for improving NK cell viability and preparation method thereof |
| CN108497496A (en) * | 2018-04-19 | 2018-09-07 | 牡丹江师范学院 | A kind of functional exercise nutriment and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103609790A (en) * | 2013-10-31 | 2014-03-05 | 安徽博格生物科技有限公司 | Tea bag capable of enhancing immunization and preventing disease |
| CN103609788A (en) * | 2013-10-31 | 2014-03-05 | 安徽博格生物科技有限公司 | Tea bag capable of enriching yin and nourishing kidney as well as invigorating yang |
| CN103609790B (en) * | 2013-10-31 | 2015-04-15 | 安徽博格生物科技有限公司 | Tea bag capable of enhancing immunization and preventing disease |
| CN103798473A (en) * | 2014-01-16 | 2014-05-21 | 戴明传 | Longevity healthcare tea |
| CN104547544A (en) * | 2014-12-26 | 2015-04-29 | 山东明仁福瑞达制药股份有限公司 | Health food composition improving immunity and eliminating chronic fatigue |
| CN104621563A (en) * | 2015-02-06 | 2015-05-20 | 甘肃宏安生乐生物科技有限公司 | Fengkang particles |
| CN105616840A (en) * | 2016-02-22 | 2016-06-01 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for improving NK cell viability and preparation method thereof |
| CN108497496A (en) * | 2018-04-19 | 2018-09-07 | 牡丹江师范学院 | A kind of functional exercise nutriment and preparation method thereof |
| CN112089770A (en) * | 2020-10-02 | 2020-12-18 | 辽宁泰阳医药科技开发有限公司 | Composition capable of improving immunity and preparation method thereof |
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