Background technology
Herba Dendrobii (Dendrobiumofficinale) is the orchid family Dendrobium herbaceos perennial, is a kind of Chinese crude drug plant being distributed in karst area, and it is gained the name, for the rare of China's emphasis second class protection relates to danger plant because epidermis presents ferrum green.Dendrobium Sw is the important Chinese medicine material of China, confirm according to pharmacology test, Herba Dendrobii is long-standing as the Chinese medicine be of illnesses and fitness, and the Shennong's Herbal of Qin Han dynasty records Herba Dendrobii " main damaging the spleen and stomach, eliminating impediment, the therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia weakness and emaciation, reinforcing YIN-essence, take thick the intestines and stomach for a long time "; Book Taoist school medical science classics " Taoist Scriptures " before more than 1,000 years is become to be classified as by Herba Dendrobii first of " China's nine large Herba mesonae chinensis "; Li Shizhen (1518-1593 A.D.) evaluates Herba Dendrobii " reinforcing YIN-essence benefit is smart, thick the intestines and stomach, never sufficient in benefit, flat gastric qi, longue meat, and Fructus Alpiniae Oxyphyllae, except frightened, made light of one's life by commiting suicide and prolonged life " in Compendium of Material Medica; Among the peoplely to be called " help Herba mesonae chinensis ", to rank first of " China's nine large Herba mesonae chinensis ", be called " medicine circle giant panda " by international medicinal plants circle.Herba Dendrobii contains the healthy medicinal active ingredient that is beneficial to man in a large number, is rich in dendrobium polysaccharide, dendrobine, aminoacid, luxuriant and rich with fragrance class etc.Modern pharmacological research finds that it has nourishing YIN and clearing away heat, reinforcing stomach reg fluid, the effects such as nourishing the lung to arrest cough, is usually used in the various disease conditions such as consumption of body fluid caused by febrile disease, xerostomia excessive thirst, after being ill deficiency-heat; There is the pharmacological actions such as defying age, antitumor, reduction blood glucose, have good curative effect in diseases such as treatment gastroenteropathy, cataract, arthritis, thromboangiitis obliterans and chronic pharyngitiss.
In recent years, along with the research that deepens continuously of Herba Dendrobii medicinal efficacy and value thereof, the a collection of product with health care is researched and developed, is produced, and defines to plant from Herba Dendrobii, produce, be worked into and sell complete industrial chain, becomes an important high-tech rich people agricultural industry.The Herba Dendrobii product that existing market is sold is mainly: iron-sheet dendrobe fresh product; Herba Dendrobii stem product (i.e. Herba Dendrobii); The compound product such as oral liquid, capsule (ball) and extractum.Chewable tablet be a kind of chew in oral cavity or suck after clothes make tablet dissolve swallow, play a role in the gastrointestinal tract or play the tablet of general action through gastrointestinal absorption, having that production technology is simple, taking convenience, effective ingredient dissolution advantages of higher.Along with the quickening of Chinese Urbanization paces and consumer are to the raising of the degree of awareness of tablet food, also in order to the townie needs of high rhythm of satisfied modern times, develop a kind of with Herba Dendrobii be primary raw material be easy to carry in preserving, all-ages chewing food is very necessary.
Chinese Patent Application No. CN201210439574.X, denomination of invention: a kind of dendrobium candidum chewable tablet, discloses a kind of dendrobium candidum chewable tablet, and it is made up of Herba Dendrobii micropowder and common medicinal supplementary material.Although the Herba Dendrobii micropowder that this chewable tablet employing particle diameter is 34 μm ~ 58 μm is raw material, greatly improve human body to the absorption of Herba Dendrobii active component.But the active component in Herba Dendrobii is still retained in Herba Dendrobii cell, is wrapped up by cellulose and pectin, bioavailability is still very low, and Herba Dendrobii is a kind of rare medicinal herbs, and can cause waste like this, cost is high.
Summary of the invention
An object of the present invention is open a kind of effective ingredient bioavailability high, another object is to provide the preparation method of this Herba Dendrobii health food.
The solution of the present invention is:
Dendrobium candidum compound chewable tablet, comprises the raw material of following parts by weight:
Herba Dendrobii extract 30 ~ 50 parts; Ganoderma 5 ~ 10 parts; Fructus Lycii 5 ~ 15;
Sweeting agent 20 ~ 30 parts; Correctives 3 ~ 5 parts; Hydroxypropyl emthylcellulose 20 ~ 30;
Maltodextrin 5 ~ 15 parts; Lubricant 1 ~ 3 part.
Described Herba Dendrobii extract is the Extraction solvent that Herba Dendrobii micropowder uses water as effective ingredient, adopts cellulase and pectase effective component extracting, then the concentrated material obtained.
Described Ganoderma is Basidiomycetes Polyporaceae (Polyporaceae) Ganoderma (Ganodelma) fungus Ganoderma lucidum (Leyss. Ex Fr.) Karst. (G.lucidumkarst).Ganoderan is one of principle active component of Ganoderma, has antitumor, immunomodulating, blood sugar lowering, antioxidation, blood fat reducing and anti-aging effects.
Described Fructus Lycii is formal name used at school: the fruit of the multi-branched shrub plant of the Solanaceae Lycium of Lyciumchinense.Fructus Lycii is famous and precious medical material and tonic, and what the traditional Chinese medical science had very early " medlar health preserving " says, is improved the effect of immunity of organisms, can QI invigorating smart by force, nourishing the liver and kidney, defying age, only quench one's thirst, warm health, antineoplastic effect.
Described sweeting agent is any one in sucrose, xylitol, Fructus Momordicae fructoside or stevioside, and sweeting agent can give chewable tablet sweet taste, and palatability is good.Fructus Momordicae fructoside and stevioside also have the advantages such as low, the applicable diabetic to take of heat.
Described correctives is any one in citric acid, malic acid or Herba Menthae, and correctives can give chewable tablet special fragrance.
Described lubricant is magnesium stearate, Pulvis Talci, Macrogol 4000 or polyethylene glycol 6000, and lubricant makes the indispensable adjuvant of tablet, and chewable tablet is chewed by oral cavity, the preparation then swallowed, and the selection of lubricant will consider mouthfeel.Water-insoluble lubricant quantity is too many, easily causes mouthfeel poor, and the cost of soluble oil wants high relatively.
The preparation method of dendrobium candidum compound chewable tablet of the present invention, comprises the steps:
(1) preparation of superfine powder:
The preparation of dendrobium candidum ultrafine powder: iron-sheet dendrobe fresh product defoliation, cleaning, is cut into the segment that 1 ~ 3cm is long, and 100 ~ 120 DEG C of hot-air seasonings lower than 5% to moisture, are pulverized with super micron mill, crossed 500 mesh sieves, obtain dendrobium candidum ultrafine powder, package spare;
The preparation of Ganoderma superfine powder: Ganoderma dry product clean water, is cut into the fritter that 1 ~ 3cm is long, and 100 ~ 120 DEG C of hot-air seasonings lower than 5% to moisture, are pulverized with super micron mill, crossed 500 mesh sieves, obtain Ganoderma superfine powder, package spare;
The preparation of Fructus Lycii superfine powder: Fructus Lycii dry product clean water, dries to moisture lower than 5% under 100 ~ 120 DEG C of hot blasts, pulverizes with super micron mill, crosses 500 mesh sieves, obtains Fructus Lycii superfine powder, package spare;
(2) preparation of Herba Dendrobii extract: above-mentioned dendrobium candidum ultrafine powder is placed in glass container, ultra-pure water is added in the ratio of 1:120, add cellulase and the pectase compound enzyme of dendrobium candidum ultrafine powder weight 2%, be 6 at pH value, temperature is lixiviate 1.5h under 60 DEG C of conditions, is warming up to 90 DEG C of enzyme denaturing 10min after having extracted, and filters, collection is lixiviating solution also, and is concentrated into solid content 50 ± 0.1%;
(3) preparation of dendrobium candidum compound chewable tablet: described dendrobium candidum ultrafine powder extract, Ganoderma superfine powder, Fructus Lycii superfine powder, sweeting agent, correctives, hydroxypropyl emthylcellulose and maltodextrin are mixed, then adding volumetric concentration is 60 ~ 70% ethanol, carry out conventional wet lay granulation, cross 20 mesh sieves, then dry at 45 DEG C, 4 ~ 6% are reached to moisture weight content, cross 60 mesh sieves, be mixed into tabletting after lubricant, make dendrobium candidum compound chewable tablet, aluminium foil bag every independent packaging can be adopted, make it lucifuge, sealing, moistureproof dust-proof.
The good effect that the present invention produces is:
1. dendrobium candidum compound chewable tablet of the present invention adopts the extract of dendrobium candidum ultrafine powder as raw material, the effective ingredient of Herba Dendrobii is more easily absorbed by the body, bioavailability is higher, and the extracting method of the extract of dendrobium candidum ultrafine powder adopts enzymatic isolation method, leaching process is very gentle, avoids the decomposition of Herba Dendrobii effective ingredient.
2. dendrobium candidum compound chewable tablet main component of the present invention also contains Ganoderma and the Fructus Lycii of integration of edible and medicinal herbs, and health-care effect is better.
3. Herba Dendrobii, Ganoderma and Fructus Lycii contain the healthy medicinal active ingredient that is beneficial to man in a large number, are rich in dendrobium polysaccharide, dendrobine, aminoacid, luxuriant and rich with fragrance class etc.Modern pharmacological research finds that it has nourishing YIN and clearing away heat, reinforcing stomach reg fluid, the effects such as nourishing the lung to arrest cough, there is the pharmacological actions such as defying age, antitumor, reduction blood glucose, have good curative effect in diseases such as treatment gastroenteropathy, cataract, arthritis, thromboangiitis obliterans and chronic pharyngitiss.
Detailed description of the invention
Embodiment 1
The preparation of dendrobium candidum ultrafine powder: iron-sheet dendrobe fresh product defoliation, cleaning, is cut into the segment that 1 ~ 3cm is long, and 100 ~ 120 DEG C of hot-air seasonings lower than 5% to moisture, are pulverized with super micron mill, crossed 500 mesh sieves, obtain dendrobium candidum ultrafine powder, package spare;
The preparation of Ganoderma superfine powder: Ganoderma dry product clean water, is cut into the fritter that 1 ~ 3cm is long, and 100 ~ 120 DEG C of hot-air seasonings lower than 5% to moisture, are pulverized with super micron mill, crossed 500 mesh sieves, obtain Ganoderma superfine powder, package spare;
The preparation of Fructus Lycii superfine powder: Fructus Lycii dry product clean water, dries to moisture lower than 5% under 100 ~ 120 DEG C of hot blasts, pulverizes with super micron mill, crosses 500 mesh sieves, obtains Fructus Lycii superfine powder, package spare;
The preparation of Herba Dendrobii extract: above-mentioned dendrobium candidum ultrafine powder is placed in glass container, ultra-pure water is added in the ratio of 1:120, add cellulase and the pectase compound enzyme of dendrobium candidum ultrafine powder weight 2%, be 6 at pH value, temperature is lixiviate 1.5h under 60 DEG C of conditions, is warming up to 90 DEG C of enzyme denaturing 10min after having extracted, and filters, collection is lixiviating solution also, and is concentrated into solid content 50 ± 0.1%.
Get Herba Dendrobii extract 30 weight portion, Ganoderma superfine powder 8 weight portion, Fructus Lycii superfine powder 10 weight portion, Fructus Momordicae fructoside 20 weight portion, citric acid 3 weight portion, hydroxypropyl emthylcellulose 20 weight portion and maltodextrin 5 weight portion mix homogeneously, add the ethanol that volumetric concentration is 60 ~ 70%, the addition of ethanol is agglomerating to make material hold, namely loosing one's grip falls apart is advisable, carry out conventional wet lay granulation, cross 20 mesh sieves, then dry at 45 DEG C, 4 ~ 6% are reached to moisture weight content, cross 60 mesh sieves, be mixed into tabletting after magnesium stearate 1 weight portion, make dendrobium candidum compound chewable tablet, with aluminium foil bag every independent packaging, make it lucifuge, sealing, moistureproof dust-proof.
Embodiment 2
Dendrobium candidum ultrafine powder, Ganoderma superfine powder, Fructus Lycii superfine powder are identical with embodiment 1 with the preparation method of Herba Dendrobii extract.
Get Herba Dendrobii extract 40 weight portion, Ganoderma superfine powder 5 weight portion, Fructus Lycii superfine powder 15 weight portion, xylitol 25 weight portion, malic acid 4 weight portion, hydroxypropyl emthylcellulose 25 weight portion and maltodextrin 10 weight portion mix homogeneously, add the ethanol that volumetric concentration is 60 ~ 70%, the addition of ethanol is agglomerating to make material hold, namely loosing one's grip falls apart is advisable, carry out conventional wet lay granulation, cross 20 mesh sieves, then dry at 45 DEG C, 4 ~ 6% are reached to moisture weight content, cross 60 mesh sieves, be mixed into tabletting after Pulvis Talci 2 weight portion, make dendrobium candidum compound chewable tablet, with aluminium foil bag every independent packaging, make it lucifuge, sealing, moistureproof dust-proof.
Embodiment 3
Dendrobium candidum ultrafine powder, Ganoderma superfine powder, Fructus Lycii superfine powder are identical with embodiment 1 with the preparation method of Herba Dendrobii extract.
Get Herba Dendrobii extract 50 weight portion, Ganoderma superfine powder 10 weight portion, Fructus Lycii superfine powder 5 weight portion, sucrose 30 weight portion, Herba Menthae 5 weight portion, hydroxypropyl emthylcellulose 30 weight portion and maltodextrin 15 weight portion mix homogeneously, add the ethanol that volumetric concentration is 60 ~ 70%, the addition of ethanol is agglomerating to make material hold, namely loosing one's grip falls apart is advisable, carry out conventional wet lay granulation, cross 20 mesh sieves, then dry at 45 DEG C, 4 ~ 6% are reached to moisture weight content, cross 60 mesh sieves, be mixed into tabletting after the Macrogol 4000 of 3 weight portions, make dendrobium candidum compound chewable tablet, with aluminium foil bag every independent packaging, make it lucifuge, sealing, moistureproof dust-proof.
Embodiment 4
Dendrobium candidum ultrafine powder, Ganoderma superfine powder, Fructus Lycii superfine powder are identical with embodiment 1 with the preparation method of Herba Dendrobii extract.
Get Herba Dendrobii extract 42 weight portion, Ganoderma superfine powder 6 weight portion, Fructus Lycii superfine powder 12 weight portion, stevioside 22 weight portion, Herba Menthae 3 weight portion, hydroxypropyl emthylcellulose 23 weight portion and maltodextrin 12 weight portion mix homogeneously, add the ethanol that volumetric concentration is 60 ~ 70%, the addition of ethanol is agglomerating to make material hold, namely loosing one's grip falls apart is advisable, carry out conventional wet lay granulation, cross 20 mesh sieves, then dry at 45 DEG C, 4 ~ 6% are reached to moisture weight content, cross 60 mesh sieves, be mixed into tabletting after the polyethylene glycol 6000 of 2 weight portions, make dendrobium candidum compound chewable tablet, with aluminium foil bag every independent packaging, make it lucifuge, sealing, moistureproof dust-proof.
Dendrobium candidum compound chewable tablet main component of the present invention is the tonic Chinese medicine of integration of edible and medicinal herbs, and safety is high, can eat for a long time, effectively can strengthen human body immunity, regain one's strength of body fast, alleviate physical fatigue, have various health-care effect concurrently, and without the need to adding any antiseptic, special taste, taking convenience, do not affect the treatment, stripping absorbs fast, and high and every the independent packaging of the bioavailability not easily moisture absorption is gone bad, and is convenient for carrying and is conducive to promoting.
The characteristic that the present invention has is as follows:
(1) regulating functional balance of organs of bowels in human body, improve body immunity, effective two-ways regulation human immunity state, internal organs are strong, energetic, the resist the disease factor, and harmful levels of pathogens invades human body.
(2) promote that human metabolism makes human nerve, endocrine operational network normal.
(3) improve myocardial function, blood vessel dilating, reduce blood pressure, promote hemopoietic function, blood fat reducing, blood sugar lowering, cholesterol reducing, alleviates atherosclerosis, blood circulation promoting and blood stasis dispelling, and impel blood leukocytes and hemoglobin to increase, wound healing is fast.
(4) human body cell metabolism number of times prolonged human body life time is strengthened, slow down aging.
(5) promote to eliminate wrinkle on the face, make people of pink and healthy-looking, spirit is changed.
Example 1, deep XX, birth in 1966, civil servant, in the past due to work busy all the year round, have no time to attend to and take good care of one's health, so that fall sick from overwork, immunity degradation, feel physical tiredness, sit down and just do not remember, inefficiency, energy do not pant plentifully, upstairs unable, easy catching a cold, hypomnesis, distraction, face gloomy unglazed, be full of wrinkles, that skin does rough, vexed meaning is dry, and suffer from hyperglycemia, hyperlipidemia, easily rush down again, cold perspiration, a large amount of alopecia, poliosis, endure serious illness puzzlement to the fullest extent, live the painful date.After alleviating a period of time by rest and western medical treatment at that time, the busy old complaint that is not careful in one's diet of work one can recur again, causes other state of an illness sometimes, permanent hospital, have an injection to take medicine and just control table and do not control root, live low quality life, upon somebody's introduction, take dendrobium candidum compound chewable tablet of the present invention, every day 3-4 sheet, every sheet 1 gram, after 2 months, skin starts to become smooth high resilience! Not alopecia, the blackening of poliosis part, a sleep improvement! Memory improves, and original disease disappears automatically! Whole people is full of youthful vigor, produces huge energy in body, and upper 6 floor ladders do not think tired without a break, get back to again for 10 epoch in vigorous health several years ago!
Example 2, clock XX, female, within 50 years old, patient is admitted to hospital on May 17th, 2013 because of " pain uncomfortable in chest, hypopnea 1 hour ", conscious pain uncomfortable in chest, shortness of breath and fatigue, cardiopalmus, has a dizzy spell. and check and see that lustreless complexion, asthenia lazyness are blind, dark tongue quality has speckle, white and thin fur, deep-thready pulse.Electrocardioscopy is shown: T1V3-6 are low flat, tcm diagnosis; Thoracic obstruction Qi deficiency blood stasis type, Western medicine diagnose: angina pectoris. eat dendrobium candidum compound chewable tablet of the present invention, take 3 day, after each 4, weak beginning alleviates for sensation of oppression over the chest with shortness of breath, cardiopalmus, and feeling of oppression and pain in the chest is kept to 1 time 2 times by every day when being admitted to hospital, time is by being kept to 10 minutes half an hour, pain degree obviously alleviates, and to 4th week, pain uncomfortable in chest is not reaccessed, only remain and slightly breathe hard and vertigo symptoms, remaining disease disappears.Check electrocardiogram: roughly normal ECG, curative effect to treat angina pectoris, ECG curative effect and clinical card marquis efficacy evaluation are effective.
Example 3, woods ××, man, life in 1966, people from Beihai, Guangxi, on June 10th, 2013 suffers from coronary heart disease at examination in hospital, frequent angina pectoris, dyspnea, is not in hospital owing to lacking of capital, edible dendrobium candidum compound chewable tablet of the present invention, every day 3-4 time, totally 30,0.3 gram every, take aftersensation in two weeks and obtain that sb.'s illness took a favorable turn, breathe smooth and easy, current anginal symptom takes a turn for the better.