CN113598371A - Dendrobium huoshanense chewable tablet and preparation method thereof - Google Patents
Dendrobium huoshanense chewable tablet and preparation method thereof Download PDFInfo
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- 241001678082 Dendrobium huoshanense Species 0.000 title claims abstract description 104
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 62
- 229940068682 chewable tablet Drugs 0.000 title claims abstract description 52
- 238000002360 preparation method Methods 0.000 title abstract description 28
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- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 29
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- 238000000034 method Methods 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 11
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 46
- 235000019359 magnesium stearate Nutrition 0.000 claims description 23
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
The invention relates to the field of food processing, and discloses a dendrobium huoshanense chewable tablet and a preparation method thereof, aiming at solving the problems of poor taste components and poor antioxidant effect of the existing chewable tablet prepared from dendrobium huoshanense, wherein the dendrobium huoshanense chewable tablet comprises the following raw material components in percentage by weight: 15-25% of pregelatinized starch, 5-15% of lactose, 0.5-1.5% of acidity regulator, 3.5% of hydroxypropyl cellulose, 30-40% of microcrystalline cellulose, 0.5-1.5% of lubricant and 20-60% of dendrobium huoshanense extract. The invention has simple and convenient process and strong practicability, and the preparation method comprises the following steps of: 20% of pregelatinized starch, 5% of lactose, 0.5% of acidity regulator, 3.5% of hydroxypropyl cellulose, 30% of microcrystalline cellulose, 1.0% of lubricant and 40% of dendrobium huoshanense extract, and the prepared dendrobium huoshanense chewable tablet is proper in sweetness and sourness, smooth and fine in mouth and strong in chewiness; also has good antioxidant activity.
Description
Technical Field
The invention relates to the technical field of food processing, in particular to a dendrobium huoshanense chewable tablet and a preparation method thereof.
Background
The dendrobium huoshanense has the effects of nourishing yin, promoting the production of body fluid, warming stomach, improving eyesight, moistening throat, protecting throat, tonifying kidney and benefiting force, is a vital medicament for nourishing yin, and has good curative effects on throat diseases, cardiovascular and cerebrovascular diseases, diabetes, cataract and the like, and also has the effects of resisting aging, enhancing human immunity, resisting inflammation and the like. However, the existing eating mode of dendrobium huoshanense is mainly used for making tea, and the problem that the chewable tablets prepared from dendrobium huoshanense have poor taste components and antioxidant effect exists.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a dendrobium huoshanense chewable tablet and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the dendrobium huoshanense chewable tablet comprises the following raw material components in percentage by weight: 15-25% of pregelatinized starch, 5-15% of lactose, 0.5-1.5% of acidity regulator, 3.5% of hydroxypropyl cellulose, 30-40% of microcrystalline cellulose, 0.5-1.5% of lubricant and 20-60% of dendrobium huoshanense extract.
Preferably, the material comprises the following raw material components in percentage by weight: 15-25% of pregelatinized starch, 5-15% of lactose, 0.5-1.5% of acidity regulator, 3.5% of hydroxypropyl cellulose, 30-40% of microcrystalline cellulose, 0.5-1.5% of lubricant and 30-50% of dendrobium huoshanense extract.
Preferably, the material comprises the following raw material components in percentage by weight: 20% of pregelatinized starch, 10% of lactose, 1% of sour agent, 3.5% of hydroxypropyl cellulose, 35% of microcrystalline cellulose, 1% of lubricant and 40% of dendrobium huoshanense extract.
Preferably, the material comprises the following raw material components in percentage by weight: 20% of pregelatinized starch, 5% of lactose, 0.5% of acidity regulator, 3.5% of hydroxypropyl cellulose, 30% of microcrystalline cellulose, 1% of lubricant and 40% of dendrobium huoshanense extract.
Preferably, the acidulant comprises citric acid.
Preferably, the lubricant comprises magnesium stearate.
A preparation method of a dendrobium huoshanense chewable tablet comprises the following steps:
step 1: preparing dendrobium huoshanense extract;
step 2: weighing the raw material components according to the weight percentage;
and step 3: fully mixing pregelatinized starch, lactose, a sour agent, hydroxypropyl cellulose and microcrystalline cellulose, adding the dendrobium huoshanense extract, and uniformly mixing to obtain a soft material;
and 4, step 4: and sieving the soft material, drying and granulating, uniformly mixing the granules and the lubricant, and tabletting the granules in a tabletting machine to obtain the dendrobium huoshanense chewable tablets.
Preferably, the preparation method of the dendrobium huoshanense extract comprises the following steps: pouring the dendrobium huoshanense into distilled water according to the ratio of 1:8, carrying out water extraction for 2 times, extracting for 90min each time, mixing the filtrates obtained in the two times, and concentrating to obtain the dendrobium huoshanense extract.
Preferably, the drying in step 4 is carried out by drying the screened soft material in an electrothermal constant temperature air drying oven at 40-60 deg.C for 15-20 min.
Preferably, the specific method for tabletting in step 4 is to weigh 500mg of granules each time and tabletting with a tabletting machine, wherein each tablet has a diameter of 12 mm.
The invention has the beneficial effects that:
the process is simple and convenient, the practicability is strong, and according to the optimal formula: 20% of pregelatinized starch, 5% of lactose, 0.5% of acidity regulator, 3.5% of hydroxypropyl cellulose, 30% of microcrystalline cellulose, 1.0% of lubricant and 40% of dendrobium huoshanense extract, and the prepared dendrobium huoshanense chewable tablet is proper in sweetness and sourness, smooth and fine in mouth and strong in chewiness; also has good antioxidant activity.
Drawings
Fig. 1 is a schematic diagram of hydroxyl radical (· OH) scavenging ability of a dendrobium huoshanense chewable tablet solution of a preparation method of the dendrobium huoshanense chewable tablet provided in experimental example 4 of the present invention;
fig. 2 is a schematic diagram of the capacity of removing superoxide anion (O2-.) by the dendrobium huoshanense chewable tablet solution of the preparation method of the dendrobium huoshanense chewable tablet provided by experimental example 5 of the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments.
Example 1
Pouring the dendrobium huoshanense into distilled water according to the proportion of 1:8, carrying out water extraction for 2 times, extracting for 90min each time, mixing the filtrates obtained in the two times, and concentrating to obtain dendrobium huoshanense extract; weighing 15 g of pregelatinized starch, 5 g of lactose, 30 g of microcrystalline cellulose, 0.5 g of citric acid, 3.5 g of hydroxypropyl cellulose, 1 g of magnesium stearate and 40 g of dendrobium huoshanense extract; fully mixing pregelatinized starch, lactose, citric acid, hydroxypropyl cellulose and microcrystalline cellulose, adding dendrobium huoshanense extract, and uniformly mixing to obtain a soft material; sieving the soft material, drying in a 40 deg.C electric heating constant temperature air blast drying oven for 20min, mixing the granules with magnesium stearate, weighing 500mg granules each time, and tabletting with a tabletting machine to obtain chewable tablet of Dendrobium huoshanense with diameter of 12 mm.
Example 2
Preparing dendrobium candidum extract in the Huoshan by the same preparation method as the embodiment 1; weighing 20 g of pregelatinized starch, 10 g of lactose, 30 g of microcrystalline cellulose, 0.5 g of citric acid, 3.5 g of hydroxypropyl cellulose, 1 g of magnesium stearate and 40 g of dendrobium huoshanense extract; fully mixing pregelatinized starch, lactose, citric acid, hydroxypropyl cellulose and microcrystalline cellulose, adding dendrobium huoshanense extract, and uniformly mixing to obtain a soft material; sieving the soft material, drying in a 40 deg.C electric heating constant temperature air blast drying oven for 20min, mixing the granules with magnesium stearate, weighing 500mg granules each time, and tabletting with a tabletting machine to obtain chewable tablet of Dendrobium huoshanense with diameter of 12 mm.
Example 3
Preparing dendrobium candidum extract in the Huoshan by the same preparation method as the embodiment 1; weighing 25 g of pregelatinized starch, 15 g of lactose, 30 g of microcrystalline cellulose, 0.5 g of citric acid, 3.5 g of hydroxypropyl cellulose, 1 g of magnesium stearate and 40 g of dendrobium huoshanense extract; the preparation method of the chewable tablet of dendrobium huoshanense is the same as that of the chewable tablet of dendrobium huoshanense in example 1.
Example 4
Preparing dendrobium candidum extract in the Huoshan by the same preparation method as the embodiment 1; weighing 25 g of pregelatinized starch, 5 g of lactose, 35 g of microcrystalline cellulose, 0.5 g of citric acid, 3.5 g of hydroxypropyl cellulose, 1 g of magnesium stearate and 40 g of dendrobium huoshanense extract; the preparation method of the chewable tablet of dendrobium huoshanense is the same as that of the chewable tablet of dendrobium huoshanense in example 1.
Example 5
Preparing dendrobium candidum extract in the Huoshan by the same preparation method as the embodiment 1; weighing 20 g of pregelatinized starch, 10 g of lactose, 35 g of microcrystalline cellulose, 0.5 g of citric acid, 3.5 g of hydroxypropyl cellulose, 1 g of magnesium stearate and 40 g of dendrobium huoshanense extract; the preparation method of the chewable tablet of dendrobium huoshanense is the same as that of the chewable tablet of dendrobium huoshanense in example 1.
Example 6
Preparing dendrobium candidum extract in the Huoshan by the same preparation method as the embodiment 1; weighing 15 g of pregelatinized starch, 15 g of lactose, 35 g of microcrystalline cellulose, 0.5 g of citric acid, 3.5 g of hydroxypropyl cellulose, 1 g of magnesium stearate and 40 g of dendrobium huoshanense extract; the preparation method of the chewable tablet of dendrobium huoshanense is the same as that of the chewable tablet of dendrobium huoshanense in example 1.
Example 7
Preparing dendrobium candidum extract in the Huoshan by the same preparation method as the embodiment 1; weighing 25 g of pregelatinized starch, 5 g of lactose, 40 g of microcrystalline cellulose, 0.5 g of citric acid, 3.5 g of hydroxypropyl cellulose, 1 g of magnesium stearate and 40 g of dendrobium huoshanense extract; the preparation method of the chewable tablet of dendrobium huoshanense is the same as that of the chewable tablet of dendrobium huoshanense in example 1.
Example 8
Preparing dendrobium candidum extract in the Huoshan by the same preparation method as the embodiment 1; weighing 15 g of pregelatinized starch, 10 g of lactose, 40 g of microcrystalline cellulose, 0.5 g of citric acid, 3.5 g of hydroxypropyl cellulose, 1 g of magnesium stearate and 40 g of dendrobium huoshanense extract; the preparation method of the chewable tablet of dendrobium huoshanense is the same as that of the chewable tablet of dendrobium huoshanense in example 1.
Example 9
Preparing dendrobium candidum extract in the Huoshan by the same preparation method as the embodiment 1; weighing 20 g of pregelatinized starch, 15 g of lactose, 40 g of microcrystalline cellulose, 0.5 g of citric acid, 3.5 g of hydroxypropyl cellulose, 1 g of magnesium stearate and 40 g of dendrobium huoshanense extract; the preparation method of the chewable tablet of dendrobium huoshanense is the same as that of the chewable tablet of dendrobium huoshanense in example 1.
The electronic analytical balance used in the preparation process is selected from Shanghai Mingqiao precision science instrument, the UV-5500 ultraviolet visible spectrophotometer is selected from Shanghai Yuan analytical instrument, the tablet hardness instrument is selected from Tianjin Tianda Sen science and technology, the rotary evaporator is selected from Shanghai Yangrong biochemical instrument factory, the electric heating constant temperature air blast drying box is selected from Shanghai Sanfa science instrument, and the single punch is selected from Shanghai Tian medicine machine manufacturing factory.
The quality of the dendrobium huoshanense chewable tablets prepared in the examples 1-9 is respectively graded according to the grading standard by 10 evaluating groups consisting of related persons, the total components of each group are counted, the average value is calculated, and the average value is taken. The sensory quality scoring standard of the dendrobium huoshanense chewable tablets is shown in table 1:
TABLE 1
Sensory evaluation results of the dendrobium huoshanense chewable tablets prepared in examples 1-9 are shown in table 2: .
TABLE 2
As can be seen from Table 2, the optimum formula of the dendrobium officinale chewable tablet is obtained when the addition amount of the microcrystalline cellulose is 30%, the addition amount of the lactose is 5% and the addition amount of the pregelatinized starch is 20%.
Furthermore, the invention also makes systematic research on the process conditions in the dendrobium huoshanense chewable tablet and the preparation method thereof, only the following test scheme that the change of the process conditions has obvious influence on the effect of the dendrobium huoshanense chewable tablet is explained, the preparation methods of the dendrobium huoshanense extract and the dendrobium huoshanense chewable tablet are the same as the example 2, the comparative experiment is carried out according to the addition amounts of the dendrobium huoshanense extract, the acidity regulator and the lubricant, and the hydroxyl radical (. OH) scavenging experiment and the superoxide anion (O2-. are carried out according to the activity measurement of the dendrobium huoshanense, specifically see the experimental examples 1-5:
experimental example 1
Weighing 20 g of pregelatinized starch, 5 g of lactose, 0.5 g of citric acid, 3.5 g of hydroxypropyl cellulose, 30 g of microcrystalline cellulose and 1.0 g of magnesium stearate, respectively adding 20 g, 30 g, 40 g, 50 g and 60 g of dendrobium huoshanense extract as comparative examples 1-5, and carrying out sensory evaluation on the dendrobium huoshanense chewable tablets prepared in the comparative examples 1-5, wherein the sensory evaluation results are shown in a table 3:
TABLE 3
| The added amount of the extract per gram | Taste and flavor | Hardness of | Tissue state | |
| 20 | 3 | 4 | 2 | 9 |
| 30 | 6 | 5 | 5 | 16 |
| 40 | 8 | 7 | 8 | 23 |
| 50 | 8 | 7 | 7 | 22 |
| 60 | 7 | 8 | 6 | 21 |
The influence of the addition amount of the dendrobium huoshanense extract on the quality of the dendrobium huoshanense chewable tablet is analyzed by table 3, and when the addition amount of the dendrobium huoshanense extract is 20 g and 30 g, the chewable tablet is loose in texture and poor in taste and flavor; when the adding amount of the dendrobium officinale extract in the Huoshan is 40 g, the chewable tablet is compact in texture and good in taste and flavor; but when the content is increased to 50 g and 60 g, the chewable tablets have no obvious difference and have poor flavor, so the optimal addition amount of the dendrobium huoshanense extract is 40 g.
Experimental example 2
Weighing 20 g of pregelatinized starch, 5 g of lactose, 3.5 g of hydroxypropyl cellulose, 30 g of microcrystalline cellulose, 1.0 g of magnesium stearate and 40 g of dendrobium huoshanense extract, respectively adding 0.5 g, 1 g and 1.5 g of citric acid as comparative examples 6-8, and carrying out sensory evaluation on the dendrobium huoshanense chewable tablets prepared in comparative examples 6-8, wherein the sensory evaluation results are shown in table 4:
TABLE 4
| Citric acid addition/g | Mouthfeel (acidity) |
| 0.5 | Has good taste and acidity |
| 1.0 | Basically harmonious sour and sweet and strong sour taste |
| 1.5 | Over-obvious sour taste and over-high acidity |
As can be seen from table 4, since the taste and acidity were better when the amount of citric acid added was 0.5 g, the optimum amount of citric acid was determined to be 0.5 g.
Experimental example 3
Weighing 20 g of pregelatinized starch, 5 g of lactose, 0.5 g of citric acid, 3.5 g of hydroxypropyl cellulose, 30 g of microcrystalline cellulose and 40 g of dendrobium huoshanense extract, respectively adding 0.5 g of magnesium stearate, 1 g of magnesium stearate and 1.5 g of magnesium stearate as comparative examples 9-11, and carrying out sensory evaluation on the dendrobium huoshanense chewable tablets prepared in comparative examples 9-11, wherein the sensory evaluation results are shown in table 5:
TABLE 5
| Magnesium stearate/g | Radius of cone/cm | Height/cm of cone | Average angle of repose/(°) |
| 0.5 | 5.03 | 2.47 | 28.4 |
| 1.0 | 5.43 | 2.17 | 22.6 |
| 1.5 | 5.53 | 2.17 | 22.3 |
As can be seen from Table 5, as the amount of magnesium stearate as a lubricant is increased, the angle of repose gradually decreases, but when the amount of magnesium stearate is increased to 1 g, the angle of repose is 22.6 degrees, and the decrease in the angle of repose is insignificant when the amount of magnesium stearate added is increased, so that the amount of magnesium stearate is finally determined to be 1 g, taking the test requirements and the production cost into consideration.
Experimental example 4
Step 1: determination of hydroxyl radical
Adding 2.00ml of salicylic acid solution and 0.5ml of FeSO4 solution into a 10ml colorimetric tube, finally adding 0.5ml of H2O2 solution, diluting to 10ml with water, oscillating and mixing at normal temperature for 5min, and measuring the absorbance value at 509 nm; performing parallel measurement for 3 times, and taking an average value;
step 2: determination of hydroxyl radical scavenging Rate
Adding a series of Dendrobium huoshanense chewable tablet solutions with different concentrations into a 10ml colorimetric cylinder, adding 0.5ml of FeSO4 solution and 2.00ml of salicylic acid solution, finally adding 0.5ml of H2O2 solution, fixing the volume to 10ml with water, oscillating and mixing at normal temperature for 5min, and measuring the respective absorbance values at 509 nm; each concentration was run in parallel for 3 times, and the average was taken; the formula for radical clearance is:
D＝[(Ao－As)]/Ao×100％，
in the formula, D is the clearance rate of free radicals, Ao is the absorbance of a blank tube, and As is the absorbance after the dendrobium huoshanense chewable tablet solution is added.
Experimental example 5
Adopting pyrogallol autoxidation method [11 ]: taking 4.5mL of HCl buffer solution with pH8.2 and 1mL of Dendrobium huoshanense chewable tablet solutions with different concentrations, balancing in a water bath at 25 ℃ for 20min, adding 0.4mL of 7 mmol/L pyrogallol, accurately reacting for 4min, measuring absorbance A at 509nm, operating each concentration for 3 times in parallel, and taking an average value. The clearance was calculated as follows.
Clearance (%) ([ Ao- (A-As) ]/Ax100
In the formula: ao is the absorbance of the sample solution replaced by distilled water;
a is the absorbance of the sample set;
as is the absorbance of the sample solution itself, and distilled water is used to replace the absorbance of pyrogallol.
The process is simple and convenient, the practicability is strong, and according to the optimal formula: 20% of pregelatinized starch, 5% of lactose, 0.5% of acidity regulator, 3.5% of hydroxypropyl cellulose, 30% of microcrystalline cellulose, 1.0% of lubricant and 40% of dendrobium huoshanense extract, and the prepared dendrobium huoshanense chewable tablet is proper in sweetness and sourness, smooth and fine in mouth and strong in chewiness; also has good antioxidant activity.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (10)
1. The dendrobium huoshanense chewable tablet is characterized by comprising the following raw material components in percentage by weight: 15-25% of pregelatinized starch, 5-15% of lactose, 0.5-1.5% of acidity regulator, 3.5% of hydroxypropyl cellulose, 30-40% of microcrystalline cellulose, 0.5-1.5% of lubricant and 20-60% of dendrobium huoshanense extract.
2. The dendrobium huoshanense chewable tablet of claim 1 is characterized by comprising the following raw material components in percentage by weight: 15-25% of pregelatinized starch, 5-15% of lactose, 0.5-1.5% of acidity regulator, 3.5% of hydroxypropyl cellulose, 30-40% of microcrystalline cellulose, 0.5-1.5% of lubricant and 30-50% of dendrobium huoshanense extract.
3. The dendrobium huoshanense chewable tablet of claim 1 is characterized by comprising the following raw material components in percentage by weight: 20% of pregelatinized starch, 10% of lactose, 1% of sour agent, 3.5% of hydroxypropyl cellulose, 35% of microcrystalline cellulose, 1% of lubricant and 40% of dendrobium huoshanense extract.
4. The dendrobium huoshanense chewable tablet of claim 1 is characterized by comprising the following raw material components in percentage by weight: 20% of pregelatinized starch, 5% of lactose, 0.5% of acidity regulator, 3.5% of hydroxypropyl cellulose, 30% of microcrystalline cellulose, 1% of lubricant and 40% of dendrobium huoshanense extract.
5. The chewable tablet of dendrobium huoshanense of claim 4, wherein the sour agent comprises citric acid.
6. The chewable tablet of dendrobium huoshanense according to any one of claims 1 to 5, wherein the lubricant comprises magnesium stearate.
7. The method for preparing the dendrobium huoshanense chewable tablet as claimed in any one of claims 1 to 6, which is characterized by comprising the following steps:
step 1: preparing dendrobium huoshanense extract;
step 2: weighing the raw material components according to the weight percentage;
and step 3: fully mixing pregelatinized starch, lactose, a sour agent, hydroxypropyl cellulose and microcrystalline cellulose, adding the dendrobium huoshanense extract, and uniformly mixing to obtain a soft material;
and 4, step 4: and sieving the soft material, drying and granulating, uniformly mixing the granules and the lubricant, and tabletting the granules in a tabletting machine to obtain the dendrobium huoshanense chewable tablets.
8. The method for preparing the dendrobium huoshanense chewable tablet according to claim 7, wherein the method for preparing the dendrobium huoshanense extract comprises the following steps: pouring the dendrobium huoshanense into distilled water according to the ratio of 1:8, carrying out water extraction for 2 times, extracting for 90min each time, mixing the filtrates obtained in the two times, and concentrating to obtain the dendrobium huoshanense extract.
9. The method for preparing chewable tablet of dendrobium huoshanense according to claim 7, wherein the drying in step 4 is carried out by drying the sieved soft material in an electrothermal constant temperature air drying oven at 40-60 ℃ for 15-20 min.
10. The method for preparing chewable tablet of dendrobium huoshanense according to claim 7, wherein the specific method for tabletting in step 4 is to weigh 500mg of granules each time and tabletting each tablet with a diameter of 12mm by using a tabletting machine.
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Application publication date: 20211105 |