CN113662186A - Rhizoma polygonati chewable tablet and preparation method thereof - Google Patents
Rhizoma polygonati chewable tablet and preparation method thereof Download PDFInfo
- Publication number
- CN113662186A CN113662186A CN202110965245.8A CN202110965245A CN113662186A CN 113662186 A CN113662186 A CN 113662186A CN 202110965245 A CN202110965245 A CN 202110965245A CN 113662186 A CN113662186 A CN 113662186A
- Authority
- CN
- China
- Prior art keywords
- rhizoma polygonati
- chewable tablet
- lubricant
- extract
- lactose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 42
- 229940068682 chewable tablet Drugs 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title abstract description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 36
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 18
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims abstract description 17
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 17
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 17
- 229920000881 Modified starch Polymers 0.000 claims abstract description 17
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 17
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 17
- 239000008101 lactose Substances 0.000 claims abstract description 17
- 239000000314 lubricant Substances 0.000 claims abstract description 17
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 17
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 17
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- 238000002156 mixing Methods 0.000 claims description 27
- 239000002245 particle Substances 0.000 claims description 26
- 241000756042 Polygonatum Species 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 238000007873 sieving Methods 0.000 claims description 14
- 239000007779 soft material Substances 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 12
- 238000005303 weighing Methods 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- 239000000047 product Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 241000037831 Polygonatum sibiricum Species 0.000 abstract description 15
- 239000008187 granular material Substances 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 5
- -1 superoxide anions Chemical class 0.000 abstract description 4
- 230000003078 antioxidant effect Effects 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 15
- 238000002835 absorbance Methods 0.000 description 9
- 239000003826 tablet Substances 0.000 description 6
- 238000007605 air drying Methods 0.000 description 5
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 5
- 238000003809 water extraction Methods 0.000 description 5
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 230000002000 scavenging effect Effects 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 230000002292 Radical scavenging effect Effects 0.000 description 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 235000003891 ferrous sulphate Nutrition 0.000 description 2
- 239000011790 ferrous sulphate Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 229940079877 pyrogallol Drugs 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 240000004980 Rheum officinale Species 0.000 description 1
- 235000008081 Rheum officinale Nutrition 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
- A23L29/04—Fatty acids or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention is suitable for the technical field of health-care food, and provides a rhizoma polygonati chewable tablet and a preparation method thereof, wherein the rhizoma polygonati chewable tablet comprises the following raw material components: microcrystalline cellulose, lactose, an acidulant, pregelatinized starch, a lubricant, rhizoma polygonati extract and hydroxypropyl cellulose; the prepared polygonatum sibiricum chewable tablet is suitable in sweetness and sourness, smooth and fine in mouth feel and strong in chewiness, and the polygonatum sibiricum chewable tablet solution has a removing effect on hydroxyl free radicals and superoxide anions, so that the polygonatum sibiricum chewable tablet has good antioxidant activity; by using magnesium stearate as a lubricant, the prepared granules have good fluidity, and the surface of the chewable tablet is smooth and fine.
Description
Technical Field
The invention belongs to the technical field of health-care food, and particularly relates to polygonatum sibiricum chewable tablets and a preparation method thereof.
Background
Rhizoma Polygonati is commonly called "rheum officinale essence", "rhizoma polygonati" or "rhizoma polygonati" according to different shapes. Has the effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney; it is commonly used for deficiency of spleen-stomach qi, fatigue, stomach yin deficiency, dry mouth, poor appetite, lung deficiency, dry cough, hemoptysis, essence and blood deficiency, soreness and weakness of waist and knees, early white beard and hair, internal heat, diabetes.
The chewable tablet is a tablet which is chewed or sucked in the oral cavity to be dissolved and then swallowed; the chewable tablet is convenient to take, has increased surface area after being chewed, can promote the dissolution and absorption of the medicine in vivo, can ensure the timely taking of the medicine even in a water-deficient state, is especially suitable for patients with poor gastrointestinal function, and can reduce the burden of the medicine on the gastrointestinal tract. The existing chewable tablets generally have no oxidation resistance and are not beneficial to the wide use of the chewable tablets.
Disclosure of Invention
The embodiment of the invention aims to provide rhizoma polygonati chewable tablets and a preparation method thereof, so as to solve the problems in the background technology.
In order to achieve the above purpose, the embodiment of the present invention provides a rhizoma polygonati chewable tablet, which comprises the following raw material components: microcrystalline cellulose, lactose, an acidulant, pregelatinized starch, a lubricant, rhizoma polygonati extract and hydroxypropyl cellulose.
Preferably, the mass ratio of the microcrystalline cellulose to the lactose to the sour agent to the pregelatinized starch to the lubricant to the rhizoma polygonati extract to the hydroxypropyl cellulose is as follows: 28-32: 3-7: 0.4-0.6: 18-22: 0.5-1.5: 35-45: 3.5.
Preferably, the mass ratio of the microcrystalline cellulose to the lactose to the sour agent to the pregelatinized starch to the lubricant to the rhizoma polygonati extract to the hydroxypropyl cellulose is as follows: 29-31: 4-6: 0.45-0.55: 19-21: 0.7-1.2: 37-42: 3.5.
preferably, the mass ratio of the microcrystalline cellulose to the lactose to the sour agent to the pregelatinized starch to the lubricant to the rhizoma polygonati extract to the hydroxypropyl cellulose is as follows: 30: 5: 0.5: 20: 1: 40: 3.5.
preferably, the lubricant is magnesium stearate.
Preferably, the acidulant is citric acid.
The preparation method of the rhizoma polygonati chewable tablet comprises the following steps:
preparing a polygonatum extract: weighing rhizoma Polygonati, adding distilled water at a ratio of 1:8, extracting with water, mixing filtrates, concentrating in rotary evaporator to obtain rhizoma Polygonati extract;
uniformly mixing weighed citric acid, lactose, microcrystalline cellulose, pregelatinized starch, a sour agent and hydroxypropyl cellulose in a ratio, slowly adding a proper amount of rhizoma polygonati extract, and manually and uniformly mixing to obtain a rhizoma polygonati soft material; sieving the soft rhizoma polygonati material with a 24-mesh sieve to change the soft material into rhizoma polygonati particles; drying the sieved polygonatum particles, sieving the dried particles with a 30-mesh sieve, adding a lubricant, uniformly mixing, and tabletting to obtain the product.
In summary, due to the adoption of the technical scheme, the method has the following beneficial effects:
the embodiment of the invention provides a rhizoma polygonati chewable tablet and a preparation method thereof, wherein the rhizoma polygonati chewable tablet is suitable in sweetness and sourness, smooth and fine in mouth feel and strong in chewiness; the rhizoma polygonati chewable tablet solution has a function of removing hydroxyl radicals and superoxide anions, so that the rhizoma polygonati chewable tablet has good antioxidant activity; by using magnesium stearate as a lubricant, the prepared granules have good fluidity, and the surface of the chewable tablet is smooth and fine.
Drawings
Fig. 1 is a line graph showing the clearance rate of hydroxyl radicals (-OH) of rhizoma polygonati chewable tablet solution in the embodiment of the invention.
FIG. 2 shows the solution of rhizoma Polygonati chewable tablet in the present invention for superoxide anion (O)2-) line graph of clearance.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the embodiments of the present invention are described in further detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the embodiments of the invention and are not limiting of the embodiments of the invention.
Example 1
Preparing a polygonatum extract: weighing 100g of rhizoma polygonati, adding distilled water according to the proportion of 1:8, carrying out water extraction for 3 times, extracting for 90min each time, combining the three filtrates, concentrating by a rotary evaporator, and finally preparing rhizoma polygonati extract;
uniformly mixing weighed 0.4g of citric acid, 3g of lactose, 28g of microcrystalline cellulose, 18g of pregelatinized starch and 3.5g of hydroxypropyl cellulose according to a ratio, slowly adding a proper amount of 35g of polygonatum extract, and uniformly mixing by hand to obtain a polygonatum soft material; sieving the soft rhizoma polygonati material with a 24-mesh sieve to change the soft material into rhizoma polygonati particles; drying the sieved polygonatum sibiricum particles in an electrothermal constant-temperature air drying oven at 70 ℃ for 30 minutes, sieving the particles with a 30-mesh sieve after drying, then adding 0.5g of magnesium stearate, uniformly mixing, weighing 500g of the well-sized polygonatum sibiricum particles each time, tabletting by using a tabletting machine, and ensuring that the sizes of the granules are consistent with each other, wherein the diameter of each tablet is 12mm, thus obtaining the product.
Example 2
Preparing a polygonatum extract: weighing 100g of rhizoma polygonati, adding distilled water according to the proportion of 1:8, carrying out water extraction for 3 times, extracting for 90min each time, combining the three filtrates, concentrating by a rotary evaporator, and finally preparing rhizoma polygonati extract;
uniformly mixing weighed 0.45g of citric acid, 4g of lactose, 29g of microcrystalline cellulose, 19g of pregelatinized starch and 3.5g of hydroxypropyl cellulose according to a ratio, slowly adding a proper amount of 37g of polygonatum extract, and uniformly mixing by hand to obtain a polygonatum soft material; sieving the soft rhizoma polygonati material with a 24-mesh sieve to change the soft material into rhizoma polygonati particles; drying the sieved polygonatum sibiricum particles in an electrothermal constant-temperature air drying oven at 70 ℃ for 30 minutes, sieving the particles with a 30-mesh sieve after drying, then adding 0.5g of magnesium stearate, uniformly mixing, weighing 500g of the well-sized polygonatum sibiricum particles each time, tabletting by using a tabletting machine, and ensuring that the sizes of the granules are consistent with each other, wherein the diameter of each tablet is 12mm, thus obtaining the product.
Example 3
Preparing a polygonatum extract: weighing 100g of rhizoma polygonati, adding distilled water according to the proportion of 1:8, carrying out water extraction for 3 times, extracting for 90min each time, combining the three filtrates, concentrating by a rotary evaporator, and finally preparing rhizoma polygonati extract;
uniformly mixing weighed 0.5g of citric acid, 5g of lactose, 30g of microcrystalline cellulose, 20g of pregelatinized starch and 3.5g of hydroxypropyl cellulose according to a ratio, slowly adding a proper amount of 40g of rhizoma polygonati extract, and uniformly mixing by hand to obtain a rhizoma polygonati soft material; sieving the soft rhizoma polygonati material with a 24-mesh sieve to change the soft material into rhizoma polygonati particles; drying the sieved polygonatum sibiricum particles in an electrothermal constant-temperature air drying oven at 70 ℃ for 30 minutes, sieving the particles with a 30-mesh sieve after drying, then adding 0.5g of magnesium stearate, uniformly mixing, weighing 500g of the well-sized polygonatum sibiricum particles each time, tabletting by using a tabletting machine, and ensuring that the sizes of the granules are consistent with each other, wherein the diameter of each tablet is 12mm, thus obtaining the product.
Example 4
Preparing a polygonatum extract: weighing 100g of rhizoma polygonati, adding distilled water according to the proportion of 1:8, carrying out water extraction for 3 times, extracting for 90min each time, combining the three filtrates, concentrating by a rotary evaporator, and finally preparing rhizoma polygonati extract;
uniformly mixing weighed 0.55g of citric acid, 6g of lactose, 31g of microcrystalline cellulose, 21g of pregelatinized starch and 3.5g of hydroxypropyl cellulose according to a ratio, slowly adding a proper amount of 42g of polygonatum extract, and uniformly mixing by hand to obtain a polygonatum soft material; sieving the soft rhizoma polygonati material with a 24-mesh sieve to change the soft material into rhizoma polygonati particles; drying the sieved polygonatum sibiricum particles in an electrothermal constant-temperature air drying oven at 70 ℃ for 30 minutes, sieving the particles with a 30-mesh sieve after drying, then adding 0.5g of magnesium stearate, uniformly mixing, weighing 500g of the well-sized polygonatum sibiricum particles each time, tabletting by using a tabletting machine, and ensuring that the sizes of the granules are consistent with each other, wherein the diameter of each tablet is 12mm, thus obtaining the product.
Example 5
Preparing a polygonatum extract: weighing 100g of rhizoma polygonati, adding distilled water according to the proportion of 1:8, carrying out water extraction for 3 times, extracting for 90min each time, combining the three filtrates, concentrating by a rotary evaporator, and finally preparing rhizoma polygonati extract;
uniformly mixing weighed 0.6g of citric acid, 7g of lactose, 32g of microcrystalline cellulose, 22g of pregelatinized starch and 3.5g of hydroxypropyl cellulose according to a ratio, slowly adding a proper amount of 45g of rhizoma polygonati extract, and uniformly mixing by hand to obtain a rhizoma polygonati soft material; sieving the soft rhizoma polygonati material with a 24-mesh sieve to change the soft material into rhizoma polygonati particles; drying the sieved polygonatum sibiricum particles in an electrothermal constant-temperature air drying oven at 70 ℃ for 30 minutes, sieving the particles with a 30-mesh sieve after drying, then adding 0.5g of magnesium stearate, uniformly mixing, weighing 500g of the well-sized polygonatum sibiricum particles each time, tabletting by using a tabletting machine, and ensuring that the sizes of the granules are consistent with each other, wherein the diameter of each tablet is 12mm, thus obtaining the product.
Example 6
This example was the same as example 3, except that the amount of magnesium stearate added was 0.7g, and the mass of the remaining raw material components in this example was the same as in example 3, and the data were partially different.
Example 7
This example was the same as example 3, and was different in part of the data in that magnesium stearate was added in an amount of 1.0g, and the remaining raw material components in this example were the same in mass as in example 3.
Example 8
This example was the same as example 3, and was different in part of the data in that magnesium stearate was added in an amount of 1.2g, and the remaining raw material components in this example were the same in mass as in example 3.
Example 9
This example was the same as example 3, and was different in part of the data in that magnesium stearate was added in an amount of 1.5g, and the remaining raw material components in this example were the same in mass as in example 3.
The products obtained in examples 1 to 5 were examined and the results are shown in Table 1.
TABLE 1
| Direction of evaluation | Results |
| Taste and flavor | Sour-sweet taste, good taste, fineness and good chewiness |
| Tissue state | Smooth surface and complete shape |
| Average hardness (Kg/mm)2) | 4.2 |
The tableting results for the products obtained in example 3, example 7 and example 9 are shown in table 1.
TABLE 1
As can be seen from table 1, the angle of repose decreases inversely with increasing amounts of magnesium stearate, which is a lubricant, but 22.6 ° when the amount of magnesium stearate added increases to 1.0%.
Verification of antioxidation effect of rhizoma polygonati chewable tablets
Taking 20 polygonatum chewable tablets prepared in example 3, namely 10.00g, crushing, adding 300mL of deionized water, uniformly mixing by using a glass rod, extracting in water bath ultrasonic waves at 55 ℃ for 1.0h, filtering, reserving filter residues, extracting for 1.0h by using the same method, mixing filtrates of the polygonatum twice, evaporating and concentrating the filtrate by using a rotary evaporator, centrifuging by using a centrifuge, and fixing the volume to 100mL by using a volumetric flask to obtain a sample solution of 100 mg/mL.
Determination of hydroxyl radical
Adding 2.00ml of salicylic acid solution and 0.5ml of ferrous sulfate solution into a 10ml colorimetric tube, finally adding 0.5ml of hydrogen peroxide solution, diluting to 10ml with water, oscillating and mixing for 5min at normal temperature, and measuring the absorbance value at 509 nm. The measurements were performed 3 times in parallel and averaged.
Determination of hydroxyl radical scavenging Rate
Adding a series of rhizoma Polygonati chewable tablet solutions with different concentrations into 10ml colorimetric tube, adding ferrous sulfate solution 0.5ml and salicylic acid solution 2.00ml, adding H2O2 solution 0.5ml, diluting with water to constant volume of 10ml, shaking and mixing at room temperature for 5min, and measuring absorbance at 509 nm. Each concentration was run in 3 replicates and averaged. The formula for radical clearance is as follows:
d ═ Ao-As) ]/Ao × 100%, where D is the radical scavenging rate, Ao is the absorbance of the blank tube, and As is the absorbance after addition of the polygonatum sibiricum chewable tablet solution, the results are shown in fig. 1.
As can be seen from figure 1, the rhizoma polygonati chewable tablet solution has a function of removing hydroxyl radicals, and the removal effect is enhanced along with the increase of the concentration within a certain range.
Superoxide anion (O2-) scavenging experiment
Adopting an auto-oxidation method of pyrogallol: taking 4.5mL of hydrogen chloride buffer solution with pH8.2 and 1mL of rhizoma polygonati chewable tablet solutions with different concentrations, balancing in a water bath at 30 ℃ for 30min, adding 0.4mL of 7mmol/L pyrogallol, accurately reacting for 4min, measuring absorbance A at 509nm, averagely operating for 3 times at each concentration, and taking the average value. Clearance was calculated as follows:
clearance (%) ([ Ao- (a-As) ]/a × 100; in the formula: ao is the absorbance of the sample solution replaced by distilled water; a is the absorbance of the sample set; as is the absorbance of the sample solution, and distilled water is used for replacing the absorbance of pyrogallol; the results are shown in FIG. 2.
From figure 2, it can be seen that the rhizoma polygonati chewable tablet solution also has a scavenging effect on superoxide anions, and the scavenging effect is enhanced along with the increase of the concentration within a certain range.
In summary, the following steps: the invention provides a rhizoma polygonati chewable tablet and a preparation method thereof, and the optimal formula of the rhizoma polygonati chewable tablet is as follows: 30% of pregelatinized starch, 5% of lactose, 0.5% of citric acid, 3.5% of hydroxypropyl cellulose, 30% of microcrystalline cellulose, 1.0% of magnesium stearate and 30% of polygonatum extract, wherein the polygonatum chewable tablet solution has a removing effect on hydroxyl radicals and superoxide anions, so that the polygonatum chewable tablet has good antioxidant activity; magnesium stearate is used as a lubricant, so that the prepared granules have good fluidity, and the surface of the chewable tablet is smooth and fine; when the magnesium stearate is 1.0g, the angle of repose is 22.6 degrees, which is beneficial to tabletting.
It will be evident to those skilled in the art that the embodiments of the present invention are not limited to the details of the foregoing illustrative embodiments, and that the embodiments of the present invention are capable of being embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the embodiments being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (7)
1. The rhizoma polygonati chewable tablet is characterized by comprising the following raw material components: microcrystalline cellulose, lactose, an acidulant, pregelatinized starch, a lubricant, rhizoma polygonati extract and hydroxypropyl cellulose.
2. The rhizoma polygonati chewable tablet of claim 1, wherein the mass ratio of the microcrystalline cellulose, the lactose, the sour agent, the pregelatinized starch, the lubricant, the rhizoma polygonati extract and the hydroxypropyl cellulose is as follows: 28-32: 3-7: 0.4-0.6: 18-22: 0.5-1.5: 35-45: 3.5.
3. the rhizoma polygonati chewable tablet of claim 2, wherein the mass ratio of the microcrystalline cellulose to the lactose to the sour agent to the pregelatinized starch to the lubricant to the rhizoma polygonati extract to the hydroxypropyl cellulose is: 29-31: 4-6: 0.45-0.55: 19-21: 0.7-1.2: 37-42: 3.5.
4. the rhizoma polygonati chewable tablet of claim 3, wherein the mass ratio of the microcrystalline cellulose to the lactose to the sour agent to the pregelatinized starch to the lubricant to the rhizoma polygonati extract to the hydroxypropyl cellulose is: 30: 5: 0.5: 20: 1: 40: 3.5.
5. the rhizoma polygonati chewable tablet according to claims 1 to 4, wherein the lubricant is magnesium stearate.
6. The rhizoma polygonati chewable tablet according to claims 1-4, wherein the sour agent is citric acid.
7. A method for preparing rhizoma Polygonati chewable tablet according to any one of claims 1-6, comprising the following steps:
preparing a polygonatum extract: weighing rhizoma Polygonati, adding distilled water at a ratio of 1:8, extracting with water, mixing filtrates, concentrating in rotary evaporator to obtain rhizoma Polygonati extract;
uniformly mixing weighed citric acid, lactose, microcrystalline cellulose, pregelatinized starch, a sour agent and hydroxypropyl cellulose in a ratio, slowly adding a proper amount of rhizoma polygonati extract, and manually and uniformly mixing to obtain a rhizoma polygonati soft material; sieving the soft rhizoma polygonati material with a 24-mesh sieve to change the soft material into rhizoma polygonati particles; drying the sieved polygonatum particles, sieving the dried particles with a 30-mesh sieve, adding a lubricant, uniformly mixing, and tabletting to obtain the product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110965245.8A CN113662186A (en) | 2021-08-23 | 2021-08-23 | Rhizoma polygonati chewable tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110965245.8A CN113662186A (en) | 2021-08-23 | 2021-08-23 | Rhizoma polygonati chewable tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113662186A true CN113662186A (en) | 2021-11-19 |
Family
ID=78544825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110965245.8A Pending CN113662186A (en) | 2021-08-23 | 2021-08-23 | Rhizoma polygonati chewable tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113662186A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111728219A (en) * | 2020-08-19 | 2020-10-02 | 广西大学 | Preparation method of polygonatum sibiricum extract and polygonatum sibiricum product |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0624937A (en) * | 1992-06-29 | 1994-02-01 | Narisu Keshohin:Kk | Mucopolysaccharide fragmentation-inhibiting agent, active oxygen-scavenging agent, antioxidative agent and cosmetic |
| CN103652731A (en) * | 2013-12-11 | 2014-03-26 | 罗永祺 | Polygonatum sibiricum chewable tablets and preparation method |
| CN111728219A (en) * | 2020-08-19 | 2020-10-02 | 广西大学 | Preparation method of polygonatum sibiricum extract and polygonatum sibiricum product |
-
2021
- 2021-08-23 CN CN202110965245.8A patent/CN113662186A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0624937A (en) * | 1992-06-29 | 1994-02-01 | Narisu Keshohin:Kk | Mucopolysaccharide fragmentation-inhibiting agent, active oxygen-scavenging agent, antioxidative agent and cosmetic |
| CN103652731A (en) * | 2013-12-11 | 2014-03-26 | 罗永祺 | Polygonatum sibiricum chewable tablets and preparation method |
| CN111728219A (en) * | 2020-08-19 | 2020-10-02 | 广西大学 | Preparation method of polygonatum sibiricum extract and polygonatum sibiricum product |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111728219A (en) * | 2020-08-19 | 2020-10-02 | 广西大学 | Preparation method of polygonatum sibiricum extract and polygonatum sibiricum product |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106420643B (en) | A kind of chewable tablets and preparation method thereof containing vitamine C sodium | |
| CN106474267A (en) | Composition with pharynx-clearing and throat-smoothing action and its preparation method and application | |
| CN113662186A (en) | Rhizoma polygonati chewable tablet and preparation method thereof | |
| CN106260086A (en) | A kind of chitosan bean curd and preparation method thereof | |
| WO2022143466A1 (en) | Medicinal and edible plant-based traditional chinese medicine composition for preventing cancers | |
| CN112915187B (en) | Traditional Chinese medicine composition capable of dispelling cold and removing dampness, preparation method and application | |
| CN107050192A (en) | It is a kind of to protect composition of eyesight and preparation method thereof | |
| CN108201060A (en) | A kind of low GI functions noodles and preparation method thereof | |
| CN114517218A (en) | Sea-buckthorn oligopeptide powder and preparation method and application thereof | |
| CN109042990A (en) | Anticancer tea and preparation method thereof | |
| CN106666147A (en) | Premixed feed for tonifying spleen and checking diarrhea of pigs and preparation method thereof | |
| CN101496869B (en) | Chinese medicine preparation for treating bronchitis | |
| CN113812548A (en) | American ginseng anti-fatigue beverage and preparation method thereof | |
| CN104839293A (en) | Health-care sweet potato dietary fiber biscuit and preparation method thereof | |
| CN110558554A (en) | Composition with effects of maintaining beauty and keeping young | |
| CN110237116A (en) | A kind of lower hyperlipidemia, hypertension, hyperglycemia composition and preparation method thereof | |
| CN105211415A (en) | A kind of food health-care tea electuary moistened the lung and relieve the cough and preparation method thereof | |
| JP2656727B2 (en) | Moisture-proof Chinese herbal granules | |
| CN111714585A (en) | Composition with anti-fatigue effect and preparation method thereof | |
| CN110384757A (en) | A kind of pressed candy and purposes improving Qi deficiency physique | |
| CN116077601B (en) | Lozenge for clearing heat, relieving cough and reducing sputum and preparation method thereof | |
| CN108125237A (en) | A kind of anti-inflammatory health products of kobadrin and its preparation process | |
| CN108782869A (en) | Stem of noble dendrobium health preserving tea | |
| CN107184639A (en) | A kind of preparation method of the Chinese medicine preparation of secondary buck | |
| CN107373275A (en) | Glucomannan effervescent tablet and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211119 |
|
| RJ01 | Rejection of invention patent application after publication |