CN107184639A - A kind of preparation method of the Chinese medicine preparation of secondary buck - Google Patents
A kind of preparation method of the Chinese medicine preparation of secondary buck Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The present invention relates to a kind of preparation method of the Chinese medicine preparation of secondary buck, comprise the following steps：Cassia seed powder is added and soaked in ethanol, boiling, suction filtration are then heated to successively, is concentrated under reduced pressure and is spray-dried, cassia seed extract powder is obtained；Kudzu-vine root powder is added and extracted in the old vinegar of red yeast rice, then the mixed liquor of the kudzu-vine root powder after extraction and the old vinegar of red yeast rice is added in ethanol and carries out ultrasonic extraction, suction filtration, concentration and vacuum drying is then carried out and crushes, obtain extraction vinegar kudzu-vine root powder；The cassia seed extract powder and extraction vinegar kudzu-vine root powder are mixed.The Chinese medicine preparation that the preparation method of the Chinese medicine preparation of the secondary buck of the present invention is obtained has effects that clearing away the liver-fire, improving eyesight decompression, the Light-headedness for effectively alleviating caused by hypertension.
Description
Technical field
The present invention relates to medical science, more particularly to a kind of preparation method of the Chinese medicine preparation of secondary buck.
Background technology
With the increasingly improvement of people's living standard, overnutrition of eating three meals a day derives modern " rich man's disease " three high diseases,
That is hypertension, hyperglycaemia and high fat of blood.Wherein high fat of blood is one of contemporary most common epidemic disease, at present according to research reports I
State's crowd's hypertension is in the severe situation that illness rate, morbidity and mortality are high, awareness is low.As China's economy is further
The progress faster of development, living-pattern preservation and aging population, hypertension number also will be further increased.With regard to depressor
Speech, Western medicine dependence is big, and the Chinese medicine that compares more is favored by patient.Chinese medicine has its own drawback again, for example, drug effect is slow, decoct fiber crops
It is tired of, therefore, the effective antihypertensive product of new type of safe is that Hypertensive Population is expected.
Vinegar not only serves as flavouring, and is preferable health food.Vinegar makees medicinal existing substantial amounts of clinical practice, vinegar
System be Chinese medicine it is brewed in commonly use means, decoction oral and coating external application it is also very common, vinegar also act as medicine extract, purification.
Confirmed through research, vinegar have the hardening of antifatigue, prevention of arterial and hypertension, improve a poor appetite, help digest, beauty, antibacterial are prevented
Mould effect.The medicines and health protection about vinegar is acted in recent years, is increasingly subject to the attention of people.Red yeast rice, is that Aspergillaceae fungi is red
The red yeast rice that aspergillus Monascus purpureus mycelium is colonized on polished rice.《Yin Shan Zhengyao, Principles of Correct Diet》Recording red yeast rice can
" invigorating the spleen, QI invigorating, middle benefit gas ".The traditional Chinese medical science thinks red yeast rice major function：It is promoting blood circulation and removing blood stasis, reinforcing spleen to promote digestion.Main diet product, abdominal fullness and distention,
Red white diarrhea；Prolonged lochia；Traumatic injury.The clinical effect of modern western scientific medical research red yeast rice is to treat and prevent the heart
Cranial vascular disease.《Essentials of Materia Medica》：" joining the army and blood-breaking, dry stomach helps digestion, promoting blood circulation and blood control traumatic injury ".The old vinegar of red koji fermentation
It is a kind of generally acknowledged healthy food, adds it to and mouthfeel is can effectively improve in medicine.Integration of drinking and medicinal herbs, it is considered to by monascus vinegar and drop
Press Chinese medicine to combine, research and develop novel form.For this two taste Chinese medicament kudzu-vine root being related to and Cassia occidentalis, research finds there are different journeys
The antihypertensive effect of degree, the two effect is more preferably.But so far, have no the piece prepared using the vinegar ferment root of kudzu vine, Cassia occidentalis as raw material
Agent.Therefore, study a kind of with low cost, safe ready, it is with health role using the vinegar ferment root of kudzu vine and cassia seed as the drop of raw material
Tablet agent will have preferable market prospects.
The content of the invention
The technical problems to be solved by the invention are：There is provided a kind of with low cost, safe ready, it is with health role with
Pass through preparation method of the root of kudzu vine and cassia seed after the old vinegar fermentation of red yeast rice for the Chinese medicine preparation of the secondary buck of raw material.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention is：
A kind of preparation method of the Chinese medicine preparation of secondary buck, comprises the following steps：
(1) it is 1 by cassia seed powder volume ratio by weight:5-10 ratio adds volumetric concentration in 50-70% ethanol
Immersion 0.5-1.5h is carried out, the mixed liquor of cassia seed powder and ethanol is then heated to boiling, and continuous heating is to maintain boiling,
Suction filtration is carried out when boiling, then the extract solution obtained after suction filtration is concentrated under reduced pressure and is spray-dried successively, Cassia is obtained
Sub- extract powder；
It is 1 by kudzu-vine root powder volume ratio by weight:3-5 ratio, which is added, carries out extraction 3-7 days in the old vinegar of red yeast rice, then will leaching
The mixed liquor of kudzu-vine root powder and the old vinegar of red yeast rice after carrying is 1 by volume:It is 65%-80%'s that 5-10 ratio, which adds volumetric concentration,
Carry out carrying out suction filtration after ultrasonic extraction, 15-30min in ethanol, the extract solution obtained after suction filtration is then concentrated into thick paste, then enter
Row vacuum drying is crushed, and obtains extraction vinegar kudzu-vine root powder；
(2) it is 1-3 by weight by the cassia seed extract powder and extraction vinegar kudzu-vine root powder:1 ratio is mixed, and is obtained
Obtain the Chinese medicine preparation of the secondary buck.
The beneficial effects of the present invention are：
(1) innovation of the present invention is to use vinegar technique, using the old vinegar of red yeast rice, the root of kudzu vine, cassia seed as main ingredient raw material, uses
Vinegar is come the root of kudzu vine that ferments, obtained vinegar kudzu-vine root powder reasonable compatibility cassia seed extract powder again, is determined most through single factor test and orthogonal experiment
Good preparation technology, ensure that the reasonability of formula, can obtain tablet during subsequent applications through tabletting, and technique is simply and conveniently；
(2) preparation method of the invention can effectively avoid the trouble that Chinese medicine decocts or made tea, and suitable city is saved soon
The crowd played；Wherein vinegar system can lift drug effect, and the vinegar root of kudzu vine can improve drug effect while can be very good to improve the Chinese medicine obtained
The taste of preparation；Again, the Chinese medicine preparation of the secondary buck of acquisition according to science formula, it is to avoid patient oneself is steeped with Chinese medicine
The drawbacks of water can not grasp consumption, accomplishes safe and efficient；
(3) raw material sources are convenient, and cheap, manufacture craft disclosure satisfy that can be very between standardized production, each composition
Good compatibility, can also promote intestines and stomach toxin expelling, so as to reach good health-care effect during secondary buck；
(4) integration of drinking and medicinal herbs theory is pharmacy sheet, and the Chinese medicine preparation for the secondary buck that the present invention is obtained can coordinate depressor
It is edible, reduce the consumption of depressor, long-term taking can effective preventing hypertension.And with carry convenient transportation, dose accurately with
And continue efficient advantage.The preparation method of the Chinese medicine preparation of the secondary buck of the present invention can provide new health blood pressure lowering for market
Product, to the new with there is provided new research direction of Chinese medicine.
Embodiment
To describe technology contents, the objects and the effects of the present invention in detail, it is explained below in conjunction with embodiment.
The design of most critical of the present invention is：It is that raw material prepares auxiliary by the root of kudzu vine and cassia seed after the old vinegar fermentation of red yeast rice
The Chinese medicine preparation of decompression.
The present invention provides a kind of preparation method of the Chinese medicine preparation of secondary buck, comprises the following steps：
(1) it is 1 by cassia seed powder volume ratio by weight:5-10 ratio adds volumetric concentration in 50-70% ethanol
Immersion 0.5-1.5h is carried out, the mixed liquor of cassia seed powder and ethanol is then heated to boiling, and continuous heating is to maintain boiling,
Suction filtration is carried out when boiling, then the extract solution obtained after suction filtration is concentrated under reduced pressure and is spray-dried successively, Cassia is obtained
Sub- extract powder；
It is 1 by kudzu-vine root powder volume ratio by weight:3-5 ratio, which is added, carries out extraction 3-7 days in the old vinegar of red yeast rice, then will leaching
The mixed liquor of kudzu-vine root powder and the old vinegar of red yeast rice after carrying is 1 by volume:It is 65%-80%'s that 5-10 ratio, which adds volumetric concentration,
Carry out carrying out suction filtration after ultrasonic extraction, 15-30min in ethanol, the extract solution obtained after suction filtration is then concentrated into thick paste, then enter
Row vacuum drying is crushed, and obtains extraction vinegar kudzu-vine root powder；
(2) it is 1-3 by weight by the cassia seed extract powder and extraction vinegar kudzu-vine root powder:1 ratio is mixed, and is obtained
Obtain the Chinese medicine preparation of the secondary buck.
In the raw material that the present invention is used：
Cassia seed is the seed of legume Cassia drying and ripening, and raw use can relax bowel, and is fried with being in the market
Common Cassia parcel, there is the effect for decompression of clearing liver and improving vision.《Herbal justice》Described in " cassia seed improving eyesight, is to grow liver and kidney benefiting, with
The latent tonifying yin in town is adopted, is the normal treatment of reinforcing, the pungent scattered wind of non-such as temperature, and stopping for cold and cool drop heat is comparable to mark disease legislator, the most favorably
Without disadvantage." and modern medicine is newly used, Cassia can be used to treat hypertension so that compatibility hawthorn, chrysanthemum, selfheal etc. are soaked.
The root of kudzu vine be legume pueraria lobata dry root, ancient prescription record can expelling pathogenic factors from muscles and skin bring down a fever, promote the production of body fluid to quench thirst, Shengyang Zhixie.In addition
Still there is effect that is clearing and activating the channels and collaterals, relieving the effect of alcohol, be solution warm and thirsty good medicine.Modern times use dizzy kudzuvine root for treating hypertension, headache, neck
Pain etc..
Study and find through inventor, monascus vinegar has good effect for reducing blood fat to a certain extent, and high fat of blood is
One of the reason for triggering hypertension, by the drying vinegar powder of monascus vinegar in itself can also tabletting, taste is unique, and price is low
It is honest and clean, but also as flavouring, the bitterness of Chinese medicine can not only be improved, be also the spotlight of the present invention with secondary buck.Use red yeast rice
The old vinegar vinegar root of kudzu vine can preferably improve effective ingredient activity, so as to realize raising drug effect.
In every case liver-Yang sthenia type hypertension and Light-headedness occurs with constipation person, danger is seen everywhere.This hair
The bright antihypertensive effect using above-mentioned two tastes medicinal material, improves antihypertensive effect, with cassia seed extract powder by the old vinegar fermentation root of kudzu vine of red yeast rice
Compatibility prepares the Chinese medicine preparation of secondary buck, thus provide it is a kind of it is cheap, be adapted to general population, it is gentle, safely and effectively
Chinese medicine preparation of secondary buck and preparation method thereof.The Chinese medicine preparation of acquisition has clearing away the liver-fire, improving eyesight decompression, effectively alleviates high blood
Effect of Light-headedness caused by pressure.
It was found from foregoing description, the beneficial effects of the present invention are：
(1) innovation of the present invention is to use vinegar technique, using the old vinegar of red yeast rice, the root of kudzu vine, cassia seed as main ingredient raw material, uses
Vinegar is come the root of kudzu vine that ferments, obtained vinegar kudzu-vine root powder reasonable compatibility cassia seed extract powder again, is determined most through single factor test and orthogonal experiment
Good preparation technology, ensure that the reasonability of formula, can obtain tablet during subsequent applications through tabletting, and technique is simply and conveniently；
(2) preparation method of the invention can effectively avoid the trouble that Chinese medicine decocts or made tea, and suitable city is saved soon
The crowd played；Wherein vinegar system can lift drug effect, and the vinegar root of kudzu vine can improve drug effect while can be very good to improve the Chinese medicine obtained
The taste of preparation；Again, the Chinese medicine preparation of the secondary buck of acquisition according to science formula, it is to avoid patient oneself is steeped with Chinese medicine
The drawbacks of water can not grasp consumption, accomplishes safe and efficient；
(3) raw material sources are convenient, and cheap, manufacture craft disclosure satisfy that can be very between standardized production, each composition
Good compatibility, can also promote intestines and stomach toxin expelling, so as to reach good health-care effect during secondary buck；
(4) integration of drinking and medicinal herbs theory is pharmacy sheet, and the Chinese medicine preparation for the secondary buck that the present invention is obtained can coordinate depressor
It is edible, reduce the consumption of depressor, long-term taking can effective preventing hypertension.And with carry convenient transportation, dose accurately with
And continue efficient advantage.The preparation method of the Chinese medicine preparation of the secondary buck of the present invention can provide new health blood pressure lowering for market
Product, to the new with there is provided new research direction of Chinese medicine.
The present invention first soaks the old vinegar of kudzu-vine root powder red yeast rice (the old vinegar of Fujian red yeast rice), and active component in medicinal material can be promoted to turn
Change, the circulation of ultrasonic assistant ethanol is extracted, and can improve purity and the property of medicine.
Further, during step (1) obtains cassia seed extract powder, 1 heating and suction filtration are carried out successively
Temporal summation is 1-2h, repeats the heating and suction filtration step 2-4 time, then by the extract solution obtained after each suction filtration mixing,
Mixed liquid is concentrated under reduced pressure and is spray-dried successively.
Further, during step (1) obtains extraction vinegar kudzu-vine root powder, repeat suction filtration 2-3 times, then will take out every time
The extract solution mixing obtained after filter, by mixed liquid concentration to thick paste.
Further, during step (1) obtains the process of cassia seed extract powder and obtains extraction vinegar kudzu-vine root powder,
After each suction filtration, ethanol is reclaimed.
Further, the Chinese medicine preparation of secondary buck step (2) obtained carries out tabletting, obtains the Chinese medicine of secondary buck
Tablet.
Further, the Chinese medicinal tablet of secondary buck is coated and filled successively sample.
Further, after coating, the surface of the Chinese medicinal tablet of the secondary buck is surrounded by colourless enteric coating, the colourless intestines
The raw material that molten clothing includes following weight percentage is prepared from：Total content is 15-20% acetyl cellulose and hydroxypropyl
Methylcellulose phthalate ester, triethyl citrate 0.1-0.2%, mono stearate glyceryl ester 0.5-1 ‰, Polyoxyethylene sorbitan
Alcohol monoleate (i.e. Tween-80) 0.5-1 ‰ and diethyl phthalate 0.5-1 ‰, the acetyl cellulose and hydroxypropyl
The weight ratio of ylmethyl cellulose phthalate is 1:1.
Further, the cassia seed powder and kudzu-vine root powder are prepared by the following method and obtained respectively：Will raw cassia seed and Pueraria lobota
Root carries out drying and processing under the conditions of 50-60 DEG C, and the life cassia seed after drying and processing is fried into audible its fragrant, Ran Houyi
It is secondary to be crushed and cross 60-80 mesh sieves, obtain the cassia seed powder and kudzu-vine root powder.
Seen from the above description, the cassia seed processing that stir-fried after being dried under the conditions of 50-60 DEG C is to reduce Cassia
Function under stronger the rushing down of son, strengthens its antihypertensive effect.Specifically, raw cassia seed can be fried into audible, it is fragrant.
Further, the original of following weight percent is added in the Chinese medicine preparation for the secondary buck that step (2) is obtained
Material：Lubricant 0.1-0.5%, disintegrant 1-4% and total content are 20-25% dry adhesives and diluent.
Seen from the above description, lubricant can be magnesium stearate, and microcrystalline cellulose may be selected and is used as dry adhesives simultaneously
With diluent, disintegrant is sodium carboxymethyl starch (CMS-Na).
Further, the raw material added in the Chinese medicine preparation for the secondary buck that step (2) is obtained also includes sugar alcohol, described
Sugar alcohol is at least one of D-sorbite, xylitol and mannitol.
Seen from the above description, the addition of sugar alcohol can be seasoned.
Embodiments of the invention 1 are：
The preparation method of the Chinese medicine preparation of the secondary buck of the present embodiment, comprises the following steps：
1) Feedstock treating：The root of kudzu vine, raw cassia seed are selected successively, removal of impurities, cleaning, in 50 DEG C of drying, use traditional Chinese medicine powder
Broken machine is crushed and crosses 60 mesh sieves, obtains kudzu-vine root powder, cassia seed powder, wherein raw Cassia is crushed after must being fried to audible its perfume (or spice).
2) preparation of cassia seed extract powder：Cassia seed powder presses 1：5 (w/v) are added after 50% ethanol immersion 0.5h, are added successively
The suction filtration of micro-boiling-while hot is boiled-kept to heat, and it is a circulation, a circulation that the suction filtration of micro-boiling-while hot is boiled-kept in above-mentioned 1 heating
1h, the above-mentioned circulation of repetition 3 times, the extract solution of 3 acquisitions is merged, while recovered alcohol, after the liquid pressure-reducing concentration after merging
It is spray-dried, cassia seed extract powder is made；
3) the old vinegar of red yeast rice：With quality glutinous rice, red yeast rice, sesame etc. for raw material, Fujian red yeast rice is prepared using traditional zymotic technique
Old vinegar；
4) preparation of vinegar kudzu-vine root powder is extracted：Kudzu-vine root powder presses 1 in right amount:After 3 (w/v) add the old vinegar extraction of Fujian red yeast rice 3 days,
By 1：5 (v/v) add suction filtration after 65% ethanol, ultrasonic extraction 15min, are repeated 3 times, and the extract solution of 3 acquisitions is merged, and
After the liquid concentration after merging to thick paste, crushing is dried under vacuum condition, obtains extracting vinegar kudzu-vine root powder；
5) compound tabletting：Cassia seed extract powder and extraction vinegar kudzu-vine root powder press 1:1 part by weight is sufficiently mixed, and is aided in
The Chinese medicine preparation of decompression, adds auxiliary material and carries out tabletting, obtain the Chinese medicinal tablet of secondary buck；The auxiliary material is by weight percentage
Including following raw material：Magnesium stearate 0.1%, microcrystalline cellulose 20%, sodium carboxymethyl starch (CMS-Na) 1%；Can root in auxiliary material
According to need add sugar alcohol seasoning；
6) it is coated：Above-mentioned Chinese medicinal tablet is coated, is allowed to be formed the Chinese medicinal tablet of colourless enteric coating peridium；In coating
Colourless enteric coating formula includes：Acetyl cellulose 7.5%, hydroxypropyl methyl cellulose phthalate 7.5%, triethyl citrate
0.1%th, mono stearate glyceryl ester 0.5 ‰, polyoxyethylene sorbitan monooleate 0.5 ‰ and diethyl phthalate
0.5‰；
7) sample is filled：The tablet of preparation is loaded on bottle, drier (such as the drying bag of existing packed parcel) is put into
Prevent the moisture absorption；
8) routine inspection of tablet：Including hardness, friability, weight differential, disintegration time limited, the time limit of leaching, assay,
Visual examination etc.；
9) secondary buck medicine composition is determined：The different main ingredient proportioning consumption of selection, vinegar powder consumption, supplementary product consumption, are carried out single
Factorial experiments, and orthogonal experiment determine optimal formula rate.
Embodiment 2
The preparation method of the Chinese medicine preparation of the secondary buck of the present embodiment, comprises the following steps：
1) Feedstock treating：The root of kudzu vine, raw cassia seed are selected, removal of impurities, cleaning, 60 DEG C of drying are crushed and mistake with medicinal herb grinder
80 mesh sieves, obtain the root of kudzu vine, cassia seed coarse powder, wherein raw Cassia is crushed after must being fried to audible its perfume (or spice).
2) preparation of cassia seed extract powder：Cassia seed powder presses 1：8 (w/v) are added after 60% ethanol immersion 1h, are carried out successively
Micro-boiling-suction filtration, a circulation 2h, repetition extraction 3 times above while hot are boiled-kept in heating, merge extract solution recovered alcohol, decompression
It is spray-dried after concentration and cassia seed extract powder is made；
3) the old vinegar of red yeast rice：With quality glutinous rice, red yeast rice, sesame etc. for raw material, Fujian red yeast rice is prepared using traditional zymotic technique
Old vinegar, or selection red yeast rice old vinegar in Fujian purchased in market；
4) preparation of monascus vinegar kudzu-vine root powder：Kudzu-vine root powder presses 1 in right amount:After 4 (w/v) add the old vinegar extraction of Fujian red yeast rice 5 days,
By 1：The EtOH Sonicate that 8 (v/v) add 70% extracts suction filtration after 30min, is repeated 3 times, and merges extract solution and is concentrated into after thick paste
Vacuum drying crushing obtains extracting vinegar kudzu-vine root powder；
5) compound tabletting：Cassia seed extract powder and extraction vinegar kudzu-vine root powder press 3:1 part by weight is sufficiently mixed, and is aided in
The Chinese medicine preparation of decompression, adds auxiliary material and carries out tabletting, obtain the Chinese medicinal tablet of secondary buck；The auxiliary material is by weight percentage
Including following raw material：Magnesium stearate 0.5%, microcrystalline cellulose 25%, sodium carboxymethyl starch (CMS-Na) 4%；Can root in auxiliary material
According to need add sugar alcohol seasoning；
6) it is coated：The Chinese medicinal tablet of above-mentioned secondary buck is coated, is allowed to be formed and is coated with colourless enteric coating
Tablet；Colourless enteric coating formula is in coating：Acetyl cellulose 10%, hydroxypropyl methyl cellulose phthalate 10%, lemon
Lemon triethylenetetraminehexaacetic acid ester 0.2%, mono stearate glyceryl ester 1 ‰, polyoxyethylene sorbitan monooleate 1 ‰ and phthalic acid two
Ethyl ester 1 ‰；
7) sample is filled：The tablet of preparation is loaded on bottle, being put into drier prevents the moisture absorption；
8) routine inspection of tablet：Including hardness, friability, weight differential, disintegration time limited, the time limit of leaching, assay,
Visual examination etc.；
9) secondary buck medicine composition is determined：The different main ingredient proportioning consumption of selection, vinegar powder consumption, supplementary product consumption, are carried out single
Factorial experiments, and orthogonal experiment determine optimal formula rate.
Embodiment 3
The preparation method of the Chinese medicine preparation of the secondary buck of the present embodiment, comprises the following steps：
1) Feedstock treating：The root of kudzu vine, raw cassia seed are selected, removal of impurities, cleaning, 55 DEG C of drying are crushed and mistake with medicinal herb grinder
70 mesh sieves, obtain the root of kudzu vine part, cassia seed powder, wherein raw cassia seed is crushed after must being fried to audible its perfume (or spice).
2) preparation of Cassia extract powder：Cassia seed powder presses 1：10 (w/v) are added after 70% ethanol immersion 1.5h, are added
Micro-boiling-suction filtration, a circulation 1.5h, repetition extraction 3 times above while hot are boiled-kept to heat, merges extract solution recovered alcohol, decompression
It is spray-dried after concentration and cassia seed extract powder is made；
3) the old vinegar of red yeast rice：With quality glutinous rice, red yeast rice, sesame etc. for raw material, Fujian red yeast rice is prepared using traditional zymotic technique
Old vinegar；
4) preparation of monascus vinegar kudzu-vine root powder：Kudzu-vine root powder presses 1 in right amount:After 5 (w/v) add the old vinegar extraction of Fujian red yeast rice 7 days,
By 1：The EtOH Sonicate that 10 (v/v) add 80% extracts suction filtration after 20min, is repeated 3 times, and merges extract solution and is concentrated into after thick paste
Vacuum drying crushing obtains extracting vinegar kudzu-vine root powder；
5) compound tabletting：Cassia extract powder and the old vinegar vinegar kudzu-vine root powder of red yeast rice press 2:1 part by weight is sufficiently mixed, and is obtained auxiliary
The Chinese medicine preparation of decompression is helped, auxiliary material is added and carries out tabletting, obtain the Chinese medicinal tablet of secondary buck；Auxiliary material percentage by weight
Than including following raw material：Magnesium stearate lubricant 0.3%, microcrystalline cellulose 22%, sodium carboxymethyl starch (CMS-Na) 2%；It is auxiliary
Sugar alcohol seasoning can be added in material as needed；
6) it is coated：The Chinese medicinal tablet of above-mentioned secondary buck is coated, is allowed to be formed and is coated with colourless enteric coating
Tablet；Colourless enteric coating formula is in coating：Acetyl cellulose 9%, hydroxypropyl methyl cellulose phthalate 9%, lemon
Triethylenetetraminehexaacetic acid ester 0.15%, mono stearate glyceryl ester 0.8 ‰, polyoxyethylene sorbitan monooleate 0.8 ‰ and O-phthalic
Diethyl phthalate 0.8 ‰；
7) sample is filled：The tablet of preparation is loaded on bottle, being put into drier prevents the moisture absorption；
8) routine inspection of tablet：Including hardness, friability, weight differential, disintegration time limited, the time limit of leaching, assay,
Visual examination etc.；
9) secondary buck medicine composition is determined：The different main ingredient proportioning consumption of selection, vinegar powder consumption, supplementary product consumption, are carried out single
Factorial experiments, and orthogonal experiment determine optimal formula rate.
Zoopery：
1. experiment material and method
1.1 experimental subjects
1.1.1 sample treatment
Test sample is various concentrations product dilution, during experiment with physiological saline by sample preparation into each dosage.
1.1.2 experimental animal and detection environmental condition
Wistar rats 8, male and female half and half (female unpregnancy), healthy cleaning grade, spontaneous hypertensive rat 32 are used in experiment
Only, male and female half and half (female unpregnancy), 150~200g of body weight.There is provided by Medical University Of Fujian's Experimental Animal Center.Detect environment
Condition, 20~25 DEG C of temperature range, RH range 50~70%, rat adapts to one week in Animal House before the test, and often
Once, adapt it to environment and detection stimulates its measuring blood pressure.
1.2 instruments and reagent
1.2.1 instrument and reagent
The noninvasive animal blood pressure measuring systems of BP-6
1.2.2 reagent
1.3 dosage are grouped and given the test agent gives the time
Experiment sets three dosage groups and a Normal group, with the 5 of human body recommended amounts, 10,20 times be respectively three agent
Amount group.It is preventative to the given the test agent time and it is therapeutic to the given the test agent time be 30d.Claim quality, numbering to 1.1.2 mouse,
4 groups are divided at random, every group 8, i.e. spontaneously hypertensive rat model are according to group, the Chinese medicinal tablet low dose group of secondary buck
(27mg/kg), middle dose group (54mg/kg) and high dose group (108mg/kg).Separately 8 health Wistar rats are taken as normal
Control group.Each medicine group rat is respectively according to above-mentioned dosage gastric infusion, and administration volume is 1mL/100g weights, normal control
The capacity distilled water such as group and spontaneously hypertensive rat model control rats gavage, once a day, continues 30 days.
Blood pressure determination determines rat tail artery systolic pressure with Bp-6 non-invasive blood pressures measuring system.Under rat rest state,
It is continuous to survey systolic pressure 3 times, average as pressure measurement result.Observation index:1. single-dose antihypertensive effect, surveys rat before administration
30 after blood pressure, first medicine, 60,90,120,240min blood pressure situation；2. successive administration decompression situation, respectively determine 1,4,7,
10th, 13,16,19,22,25, after 28d medicines 30min blood pressures (from single-dose result, secondary buck piece high dose group is in medicine
30min starts to work afterwards), daily duplicate measurements 3 times takes averaging of income value as final pressure value.
1.4 data statistics：Statistical analysis is carried out using the softwares of IBM SPSS Statistics 20.
2 experimental results
Influence of the Chinese medicinal tablet of 2.1 secondary bucks to Wistar rat blood pressures
Table 1 for secondary buck Chinese medicinal tablet to Wistar rat blood pressures influence (N=10) table.
Table 1
Note：Compared with blank control group, * P<0.05；**P<0.01.
As shown in Table 1, Wistar rats are fed under the conditions of blank after 4 weeks, the blood pressure of Wistar rats persistently increases.Give
The Chinese medicinal tablet and captopril of secondary buck are after 4 weeks, and the blood pressure of Wistar rats has different degrees of decline, is dropped with giving
Blood pressure product and captopril time continue, and Wistar rat blood pressures, which gradually slow down, to tend to be steady, and with blank control group phase
Than significantly reducing (P<0.05), in reduced levels；High dose group compares blood pressure reduction -16mmHg, middle dosage compared with control group
Group is than control group blood pressure reduction -12mmHg, low dose group reduction -4.9mmHg.Illustrating the Chinese medicinal tablet of secondary buck has significantly
Blood pressure lowering effect, can be used as auxiliary function for lowering blood pressure food.
Influence of the Chinese medicinal tablet of 2.2 secondary bucks to Wistar rat heart rates
Table 2 is influence of the Chinese medicinal tablet of secondary buck to Wistar rat heart ratesTable.
Table 2
As shown in Table 2, with the not notable (P of rat heart rate change after experiment before data result analysis is tested>0.05), and each
Dosage does not make a significant impact (P to rat heart rate>0.05), mouse growth is good.
Above-mentioned results of animal is shown：Before experiment compared with after experiment, the change of Wistar rat heart rates is poor without conspicuousness
Different (P>0.05), illustrate that the red koji fermentation root of kudzu vine Cassia secondary buck piece does not have harmful effect to the normal growth and development of rat；
The pressure value of Wistar rats is according to the decline of dosage showed different, high dose group decline about 9.37%, middle dose group decline
About 7.03%, low dose group declines about 2.87%.The Chinese medicinal tablet of description of test secondary buck has good blood pressure reduction effect.
The specific implementation step be the same as Example 1 of zoopery, experimental result is shown, the Chinese medicinal tablet pair of secondary buck
The pressure value of Wister rats has a significant impact, and can significantly reduce pressure value for 15.83mmHg, and heart rate to rat, body weight
Do not make significant difference (P>0.05) Wister rat normal growths, are not hindered.
In summary, the Chinese medicine preparation that the preparation method of the Chinese medicine preparation for the secondary buck that the present invention is provided is obtained has clear
Irascibility, improving eyesight decompression, effect of effective Light-headedness for alleviating caused by hypertension.
Embodiments of the invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize this hair
The equivalents that bright description is made, or the technical field of correlation is directly or indirectly used in, similarly it is included in this hair
In bright scope of patent protection.
Claims (10)
1. a kind of preparation method of the Chinese medicine preparation of secondary buck, it is characterised in that comprise the following steps：
(1) it is 1 by cassia seed powder volume ratio by weight:5-10 ratio adds volumetric concentration to carry out in 50-70% ethanol
0.5-1.5h is soaked, the mixed liquor of cassia seed powder and ethanol is then heated to boiling, and continuous heating is to maintain boiling, in boiling
Suction filtration is carried out when rising, then the extract solution obtained after suction filtration is concentrated under reduced pressure and is spray-dried successively, cassia seed leaching is obtained
Cream powder；
It is 1 by kudzu-vine root powder volume ratio by weight:3-5 ratio, which is added, carries out extraction 3-7 days in the old vinegar of red yeast rice, after then extracting
The mixed liquor of kudzu-vine root powder and the old vinegar of red yeast rice be 1 by volume:5-10 ratio adds volumetric concentration in 65-85% ethanol
Suction filtration is carried out after carrying out ultrasonic extraction, 15-30min, the extract solution obtained after suction filtration is then concentrated into thick paste, then carry out vacuum
Drying and crushing, obtains extraction vinegar kudzu-vine root powder；
(2) it is 1-3 by weight by the cassia seed extract powder and extraction vinegar kudzu-vine root powder:1 ratio is mixed, and obtains institute
State the Chinese medicine preparation of secondary buck.
2. the preparation method of the Chinese medicine preparation of secondary buck according to claim 1, it is characterised in that step (1) is obtained
During cassia seed extract powder, successively carry out 1 time it is described heating and suction filtration temporal summation be 1-2h, repeat it is described heating and
Suction filtration step 2-4 times, then the extract solution obtained after each suction filtration is mixed, mixed liquid is concentrated under reduced pressure successively
And spray drying.
3. the preparation method of the Chinese medicine preparation of secondary buck according to claim 1, it is characterised in that step (1) is obtained
During extracting vinegar kudzu-vine root powder, suction filtration is repeated 2-3 times, then the extract solution obtained after each suction filtration is mixed, will be mixed
Liquid concentration afterwards is to thick paste.
4. the preparation method of the Chinese medicine preparation of the secondary buck according to Claims 2 or 3, it is characterised in that step (1) is obtained
During obtaining the process of cassia seed extract powder and obtaining extraction vinegar kudzu-vine root powder, after each suction filtration, ethanol is reclaimed.
5. the preparation method of the Chinese medicine preparation of secondary buck according to claim 1, it is characterised in that obtain step (2)
The Chinese medicine preparation of the secondary buck obtained carries out tabletting, obtains the Chinese medicinal tablet of secondary buck.
6. the preparation method of the Chinese medicine preparation of secondary buck according to claim 5, it is characterised in that by secondary buck
Chinese medicinal tablet is coated and filled successively sample.
7. the preparation method of the Chinese medicine preparation of secondary buck according to claim 6, it is characterised in that after coating, described
The surface of the Chinese medicinal tablet of secondary buck is surrounded by colourless enteric coating, and the colourless enteric coating includes the original of following weight percentage
Material is prepared from：Total content is 15-20% acetyl cellulose and hydroxypropyl methyl cellulose phthalate, triethyl citrate
0.1-0.2%, mono stearate glyceryl ester 0.5-1 ‰, polyoxyethylene sorbitan monooleate 0.5-1 ‰ and phthalic acid
Diethylester 0.5-1 ‰, the weight ratio of the acetyl cellulose and hydroxypropyl methyl cellulose phthalate is 1:1.
8. the preparation method of the Chinese medicine preparation of secondary buck according to claim 1, it is characterised in that the cassia seed powder
It is prepared by the following method and obtains respectively with kudzu-vine root powder：Raw cassia seed and the root of kudzu vine are dried under the conditions of 50-60 DEG C
Processing, is then crushed and is crossed successively 60-80 mesh sieves, the cassia seed powder and kudzu-vine root powder is obtained, by the life after drying and processing
Cassia seed is fried to audible, and it is fragrant, then carries out the crushing.
9. the preparation method of the Chinese medicine preparation of secondary buck according to claim 1, it is characterised in that obtained in step (2)
The raw material of following weight percent is added in the Chinese medicine preparation of the secondary buck obtained：Lubricant 0.1-0.5%, nanometer titanium dioxide
Silicon 0.5-1.5%, disintegrant 1-4% and total content are 20-25% dry adhesives and diluent.
10. the preparation method of the Chinese medicine preparation of secondary buck according to claim 9, it is characterised in that obtained in step (2)
The raw material added in the Chinese medicine preparation of the secondary buck obtained also includes sugar alcohol, and the sugar alcohol is D-sorbite, xylitol and sweet dew
At least one of sugar alcohol.
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| CN112190668A (en) * | 2020-10-26 | 2021-01-08 | 焦作赛科中药生物科技有限公司 | Fermented traditional Chinese medicine tea assisting in lowering blood pressure and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101760478A (en) * | 2009-08-11 | 2010-06-30 | 杭州千岛湖星遥实业有限公司 | Preparation method of radix puerariae red yeast rice |
| CN101991786A (en) * | 2009-08-28 | 2011-03-30 | 江春艳 | Formula of medicine for reducing blood fat and preparations thereof |
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2017
- 2017-06-14 CN CN201710446727.6A patent/CN107184639A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101760478A (en) * | 2009-08-11 | 2010-06-30 | 杭州千岛湖星遥实业有限公司 | Preparation method of radix puerariae red yeast rice |
| CN101991786A (en) * | 2009-08-28 | 2011-03-30 | 江春艳 | Formula of medicine for reducing blood fat and preparations thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190668A (en) * | 2020-10-26 | 2021-01-08 | 焦作赛科中药生物科技有限公司 | Fermented traditional Chinese medicine tea assisting in lowering blood pressure and preparation method thereof |
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