CN101745042B - Composition with effects of relieving alcoholism and protecting liver and preparation method thereof - Google Patents
Composition with effects of relieving alcoholism and protecting liver and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a composition with effects of relieving alcoholism and protecting liver and a preparation method thereof, belonging to the field of health foods. The composition is mainly prepared from kudzu root, oyster, cogongrass rhizome, pericarpium citri reticulatae, liquorice and honey powder in a certain proportion by weight. To achieve a better effect, prunella vulgaris and angelica can also be added. The composition can be prepared into any common formulation and preferably granules. The composition is prepared from traditional Chinese medicines with homology of medicine and food, has the effects of relieving alcoholism and protecting the liver, clearing away heat and promoting salivation, regulating the flow of qi and strengthening the spleen, and relieving vigorous liver fire and headache after drinking alcohol, and is especially suitable for taking after drinking alcohol.
Description
Technical field
The present invention relates to a kind of composition and method of making the same, belong to field of health care food with effects of relieving alcoholism and protecting liver.
Background technology
In daily life and social communication, the situation of insobriety is usually arranged, drunk back people often have symptoms such as unconsciousness, headache, regurgitation, and severe patient also can alcoholism.Drinking for a long time damages liver inevitably, and excessive consumption of alcohol has caused people's great attention to the infringement of human body.The invention provides a kind of health food that utilizes integration of edible and medicinal herbs Chinese medicine to process, solved this problem, promoted that people's is healthy with effects of relieving alcoholism and protecting liver.
Among October in 2002 invention disclosed patent application prospectus on the 2nd CN1371732A; Disclose a kind of alcohol-decomposing beverage, its raw material consists of Radix Puerariae, Concha Ostreae, Poria, Rhizoma Dioscoreae, Fructus Crataegi, Semen Lablab Album, Bulbus Lilii, Semen Phaseoli, Fructus Canarii, Semen Nelumbinis, Fructus Mori, Semen Coicis, Radix Glycyrrhizae, Fructus Amomi, Flos Chrysanthemi, Fructus Momordicae, fresh Rhizoma Phragmitis, fresh Rhizoma Imperatae, Pericarpium Citri Reticulatae, Rhizoma Zingiberis Recens, Rhizoma Zingiberis, Fructus Jujubae, Mel.This prescription component is numerous, is made up of 23 kinds of raw materials, and this invention has the too much efficacy of a drug of component not concentrate the shortcoming that influences the effect of relieving the effect of alcohol.
Summary of the invention
The object of the invention provides a kind of compositions with effects of relieving alcoholism and protecting liver.Another object of the present invention has provided the method for preparing of said composition.
The present invention is mainly processed by the following weight proportion raw material: Radix Puerariae, Concha Ostreae, Rhizoma Imperatae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Mel powder.The weight proportion of compositions is preferably: Radix Puerariae 3-20 part, Concha Ostreae 10-20 part, Rhizoma Imperatae 1-5 part, Pericarpium Citri Reticulatae 1-5 part, Radix Glycyrrhizae 1-5 part, Mel powder 1-3 part.
Further be preferably: 15 parts of Radix Puerariaes, 15 parts of Concha Ostreaes, 3 parts of Rhizoma Imperataes, 3 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 1.5 parts of Mel powder.
The mechanism of action of the present composition is following:
Radix Puerariae has expelling pathogenic factors from muscles to be delivered, and letting eruptions out with drugs of pungent flavor and cool nature is brought down a fever and promoted the production of body fluid, the antidiarrheal of quenching the thirst, the effect of elevate a turnable ladder yang-energy.It has the record of antialcoholism action to have for 2,000 quincentenaries at least, points out in Tang Dynasty's " Treatise on Dietetic Therapy ": " the Radix Puerariae steamed wheaten foods it, alcoholism disappears." " prescriptions worth thousand gold ", " property of medicine opinion " are also put down in writing Radix Puerariae " alcoholic intoxication ", " control drunk do not wake up " " Chinese medicine voluminous dictionary " carries: Radix Puerariae, the tool heat-clearing and toxic substances removing, spasmolysis and analgesia, the yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal increases brain and coronary blood flow, improves effects such as brain microcirculation.The experiment of Wang Qingduan etc. shows that the total flavones composition in the Radix Puerariae can improve mice to alcoholic acid dosis tolerata, the time of righting reflex loss when shortening mice heavy dose ethylism, and shorten the incubation period of sleeping, reduce ethanol content in the blood.Pharmacological research shows that Radix Puerariae has stronger antialcoholism action, effectively the liver and the testis tissue lipid peroxidation damage that cause of antagonism ethanol; Radix Puerariae contains daidzin, and it can decompose acetaldehyde toxicity, and prevention ethanol weakens the brain inhibit feature, suppresses the absorption of the intestines and stomach to ethanol, promotes the metabolism and the drainage of ethanol in the blood.Radix Puerariae also has antioxidation in addition, the enhanced effect of immunologic function, and can blood sugar lowering, blood fat, improve blood circulation, have the effect of stronger enhancing cardio and vascular function.The pathological research data shows that taking the hepatocyte that Radix Puerariae water extract can reduce due to the ethanol produces steatosis.
Concha Ostreae has yin fluid astringing, YANG hyperactivity suppressing, and hidroschesis, arresting seminal emission reduces phlegm, the effect of softening the hard mass.Li Shizhen (1518-1593 A.D.) in Compendium of Material Medica, also say Concha Ostreae " meat is controlled deficient, separates dysphoria with smothery sensation after drinking ... sliding skin, the Concha Ostreae resolving phlegm and softening hard masses, removing damp-heat ends heart temper pain, reddish and whitish turbid urine under the dysentery, the hernia that disappears is amassed piece." the supplement to the Herbal meaning: " it is main deficient to cook, and married woman's vim and vigour are in the accent ... In Rhizoma Zingiberis Recens vinegar, eat it raw, control erysipelas, dysphoria with smothery sensation is quenched the thirst after drinking." " food secretary " meaning: " heat clearing away in the accent, is made us thin skin, U.S. color." the modern study result shows; Concha Ostreae mainly contains each seed amino acid and glycogen such as taurine, glycine, methionine, cystine, glutamic acid; can improve liver function and promote Detoxication, and the metabolite acetaldehyde of ethanol is decomposed rapidly, becomes innocuous substance; thus reduce the harm of ethanol, and prevention is still drank after a night and is disliked liquor-saturated.In addition, liver cell is destroyed behind the heavy drinking, and aminoacid is to repair the material that these decrease broken cell.Pharmacological research proves that it can obviously protect gastric mucosa to avoid the ethanol damage, and significantly reducing by the coat of the stomach circulating load due to the ethanol increases, and improves the blood capillary microcirculation, thereby obviously improves by the peripheral circulation disorders due to the ethanol; And can reduce the hepatic tissue lipid peroxide contents, with the radical pair lipid peroxidation injury effect of opposing ethanol in hepatic tissue; It can improve superoxide dismutase (SOD) vigor of serum and hepatic tissue, and SOD can remove ultra-oxygen anion free radical that ethanol produces and the stabilizing cell membrane system in the hepatocyte metabolic process, thereby plays the hepatocellular effect of protection; It can accelerate ethanol in the intravital metabolic process of people; Remove ethanol and formaldehyde to hepatocellular coup injury (mainly be to have shortened the ethanol and the metabolite time of staying in vivo thereof, reduced the absorption of internal organs, reduced the alcohol concentration in the unit interval inner blood) to these materials; Thereby alcoholism there are tangible prevention and therapeutical effect; It is slow that drunk existing picture is occurred, and drunk degree alleviates, and obviously shortens and sober up the time; Accelerate ataxic after drinking recovery, reduce the concentration of ethanol in the serum.
Rhizoma Imperatae has clearing away heat and promoting production of body fluid, cooling blood for hemostasis, diuretic effect.Cold in nature because of its sweet in the mouth, the heat of kind lung heat clearing, stomach is because of it has the diuretic effect, so ability heat conduction is descending.Its feature is: sweet in the mouth and mud diaphragm not, and cold in nature and do not hinder stomach, diuretic and non-impairment of YIN has YIN fluid being insufficient phenomenon person especially with heat symptom-complex, the most suitable.The Compendium of Material Medica cloud: " Rhizoma Imperatae, sweet ability remove latent heat, diuresis, so can end at blood, hiccup, dyspnea with rapid respiration, quench one's thirst, the subcutaneous ulcer of harnessing the Yellow River edema, be good thing also.The all blood of emesis nosebleed, typhoid fever hiccup, lung-heat dyspnea with rapid respiration, edema, jaundice, alcoholic intoxication." pharmacological research shows, clothes are irritated in Rhizoma Imperatae decoct and water logging agent, and normal rabbits is had diuresis, and contained to enrich potassium salt relevant with it to think the diuresis of Rhizoma Imperatae.
Pericarpium Citri Reticulatae is claimed Pericarpium Citri tangerinae again, and is warm in nature, bitter in the mouth, suffering.The merit that appetizing, drying dampness to eliminate phlegm in circulation of qi promoting spleen invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, the accent are arranged.Be used for due to the stagnation of QI in spleen and stomach distension and fullness in the abdomen, belch, feel sick, the diseases such as cough with copious phlegm of the thin and phlegm dampness obstruction pattern in indigestion and loss of appetite asthenia, big loose stool due to vomiting and the retention of dampness in middle-JIAO.Compendium of Material Medica speech its " it is noisy that sound of vomiting regurgitation is told in treatment, the time vomiting watery fluid, fullness and oppression sensation in the epigastrium due to accumulation of phlegm, intermittent fever due to phlegm, big enteremphraxis, married woman's acute mastitis.”。In addition; Pericarpium Citri Reticulatae also has the antialcoholic effect; " book on Chinese herbal medicine covers bamboo fish trap " claimed its ability " alcoholic intoxication ", its ability of Compendium of Material Medica meaning " it is sick to treat wine ", " Shengji Zonglu " year " can treat insobriety with JUPITANG "; The chances are for its mechanism because of Pericarpium Citri Reticulatae preventing or arresting vomiting, appetizing, can effectively alleviate the uncomfortable all diseases of taste due to the insobriety.Pericarpium Citri Reticulatae mainly contains volatile oil, flavonoid glycoside (like hesperidin), inositol, vitamin B1 etc.Pharmacology analysis shows that the contained volatile oil of Pericarpium Citri Reticulatae has gentle stimulation to gastrointestinal tract, but pneumatosis in the intestinal tube is got rid of in the secretion of facilitating digestion liquid, has shown that fragrance is good for the stomach and the effect of the wind dispelling therapeutic method to keep the adverse QI flowing downwards.
The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.TAO Hong-Jing is " state is old " with the Radix Glycyrrhizae honor, and speech: " king of the most medicines of this grass, classical prescription is rare without the person." " state is old ", i.e. Supreme Being teacher's title.Release in the Compendium of Material Medica: " Radix Glycyrrhizae is monarch in all medicines, controls 72 kinds of mammary calculus poison, separates 1,002 BAICAO wood poison, and many medicines that are in harmonious proportion are meritorious, thus have ' state is old ' number.”
The Mel invigorating middle warmer is moisturized, pain relieving, detoxifcation.Compendium of Material Medica cloud its " the moist pain relieving of heat-clearing and toxic substances removing invigorating middle warmer is also ", " Bencao Jingshu " said: " SHIMI, its gas is cleer and peaceful, and it distinguishes the flavor of pure sweet, the spiritual QI and blood of executing, the deficiency and excess cold and heat, negative and positive are inside and outside all sick, deceive unsuitable ".
Radix Puerariae is the most representative medicine that relieves the effect of alcohol in the traditional medicine, is monarch drug; Concha Ostreae contains several amino acids such as taurine, can strengthen the nourishing the liver hepatoprotective, and Rhizoma Imperatae clearing away heat and promoting production of body fluid and diuresis help the Radix Puerariae facilitating alcohol metabolism and protecting liver altogether, are ministerial drug; The gas spleen invigorating of supervising the cooking of Pericarpium Citri Reticulatae (claiming Pericarpium Citri tangerinae again) merit, drying dampness to eliminate phlegm is mainly used in fullness in the epigastrium and chest, lack of appetite and vomiting, is adjuvant drug, helps monarch-minister drug to alleviate all diseases of feeling of fullness lack of appetite after drinking; The Radix Glycyrrhizae invigorating the spleen and replenishing QI with in, the Mel invigorating middle warmer is moisturized, analgesic antidotal, the two share coordinating the actions of various ingredients in a prescription, is messenger drug.Six medicines are harmonious, and have that Antialcoholic liver-protecting, clearing away heat and promoting production of body fluid, regulating qi-flowing for strengthening spleen, invigorating middle warmer are moisturized, the analgesic antidotal effect, especially can be in taking after drinking.
In order to reach better effect, also can add Spica Prunellae, the Radix Angelicae Dahuricae.The weight proportion of compositions is preferably: Radix Puerariae 3-20 part, Concha Ostreae 10-20 part, Rhizoma Imperatae 1-5 part, Pericarpium Citri Reticulatae 1-5 part, Radix Glycyrrhizae 1-5 part, Mel powder 1-3 part, Spica Prunellae 3-8 part, Radix Angelicae Dahuricae 3-8 part.
Further be preferably: 5 parts of Radix Puerariaes, 15 parts of Concha Ostreaes, 3 parts of Rhizoma Imperataes, 3 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 1.5 parts of Mel powder, 5 parts of Spica Prunellaes, 5 parts of the Radixs Angelicae Dahuricae.
The hot hardship of loosing of Spica Prunellae is let out, and Liver Channel is solely gone in heat clearing away cold in nature, the function clearing away liver-fire, and the liver benefiting is cloudy, is longer than making eye bright, but the eliminating stagnation of holding concurrently.For containing key medicine in the liver-fire.
The Radix Angelicae Dahuricae is warm in nature, and acrid in the mouth is returned stomach, lung, large intestine channel.Expelling cold and relieving exterior syndrome is arranged, dispeiling pathogenic wind and removing dampness, pain relieving, the effect of detumescence and apocenosis.The Compendium of Material Medica record: " Radix Angelicae Dahuricae, the capable hands sun of the white acrid in the mouth of color is bright, and gas warm in nature is thick ... wind heat person's suffering is to loose it, and wet person's temperature is to remove it." successive dynasties name side loose etc. like Notoptreygium Decoction of Nine Ingredients, decoction for dispelling pathogens from superficial muscles, huoxiang zhengqi powder, daqinjiao decoction, Xian fang Huoming Yin, Yuzhen San, the Chinese herbaceous peony root of Dahurian angelica and all have the Radix Angelicae Dahuricae to be used as medicine.
Radix Puerariae is the most representative medicine that relieves the effect of alcohol in the traditional medicine, is monarch drug; Concha Ostreae contains several amino acids such as taurine, can strengthen the nourishing the liver hepatoprotective, and Rhizoma Imperatae clearing away heat and promoting production of body fluid and diuresis help the Radix Puerariae facilitating alcohol metabolism and protecting liver altogether, are ministerial drug; It is must liver-fire vigorous often to drink then, and the Spica Prunellae toil is cold in nature, and the power of clearing away liver-fire is stronger, and can Disperse hepatic depression; Radix Angelicae Dahuricae wind-expelling pain-stopping power is strong, mainly controls headache, supraorbital bone pain, toothache; The gas spleen invigorating of supervising the cooking of nasal sinusitis pain etc., Pericarpium Citri Reticulatae (claiming Pericarpium Citri tangerinae again) merit, drying dampness to eliminate phlegm is mainly used in fullness in the epigastrium and chest, lack of appetite and vomiting; Three medicines share, and are adjuvant drug altogether, help that monarch-minister drug alleviates after drinking that liver-fire is vigorous, headache, all diseases of feeling of fullness lack of appetite; The Radix Glycyrrhizae invigorating the spleen and replenishing QI with in, the Mel invigorating middle warmer is moisturized, analgesic antidotal, the two share coordinating the actions of various ingredients in a prescription, is messenger drug.Eight medicines are harmonious, and have Antialcoholic liver-protecting, clearing away heat and promoting production of body fluid, regulating qi-flowing for strengthening spleen, invigorating middle warmer and moisturize, alleviate that liver-fire after drinking is vigorous, the effect of headache, especially can be in taking after drinking.
The method for preparing of the present composition is following:
Above-mentioned raw materials except that Mel powder, extracting in water 1-3 time, each 1-3 hour; Filter, filtrating concentrates, drying; Pulverize, get dry extract, add Mel powder; Required various conventional adjuvant when adding the preparation different dosage form is prepared into any peroral dosage form commonly used like disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, like granule, pill, tablet, capsule, oral liquid etc.
The process for producing granula of the present composition is following:
Above-mentioned raw materials except that Mel powder, extracting in water 2 times, each 8 times of amounts were extracted 1.5 hours, filtered, filtrating concentrates, drying is pulverized, and adds Mel powder, adds adjuvant, mixing use 90% alcohol granulation, drying is packed, and promptly gets.
The preferred for preparation method of present composition granule is following:
Above-mentioned raw materials except that Mel powder, extracting in water 2 times, each 8 times of amounts were extracted 1.5 hours, filtered; Filtrating concentrates, and drying is pulverized, and adds Mel powder, adds maltose alcohol or cane sugar powder, sucralose, citric acid; Mixing is used 90% alcohol granulation, drying, and packing promptly gets.
Wherein maltose alcohol and cane sugar powder be as diluent and filler and have the function of rectifying flavor concurrently, sucralose as sweeting agent, citric acid as correctives.
The specific embodiment
Below come further to set forth the beneficial effect of compositions according to the invention through Test Example.
Test Example 1: the present composition is to the relieve the effect of alcohol influence of ability of mice
1 material:
The present composition; The sample that makes according to CN1371732A embodiment 1; 56 ° of Red Star strong, colourless liquor distilled from sorghum, Beijing Red Star strong, colourless liquor distilled from sorghum brewery produces; The animal Kunming mouse, body weight 20～22g, male and female half and half.
2 methods and result:
Get 40 of Kunming mouses, the male and female dual-purpose is at laboratory rearing 1d.Fasting 5h then is divided into model group (blank group), CN1371732A organizes (concentrated solution 0.4ml/20g) at random behind the labelling of weighing; Dose groups in the present composition (concentrated solution 0.3ml/20g), heavy dose of group (concentrated solution 0.5ml/20g), 10 every group.The filling stomach to medicated wine amount 0.25ml/20g, is given administration immediately after drinking to wine earlier, and the blank group gives distilled water.With the righting reflex loss is the sleep index, calculates tolerance time (irritating the time of stomach to righting reflex loss from ethanol) and liquor-saturated sleeping the time (time from righting reflex loss to recovery).3 groups of data are carried out one factor analysis of variance handle, the result sees table 1-2.
Table 1 present composition to the influence of the liquor-saturated tolerance time of sleeping of mice (
-X ± s)
Compare * P＜0.01, * * P＜0.01 with model group; Compare * P＜0.01, * * P＜0.01 with the CN1371732A group
Table 2 present composition to the liquor-saturated influence of holding time of sleeping of mice (
-X ± s)
Compare * P＜0.01, * * P＜0.01 with model group; Compare * P＜0.01, * * P＜0.01 with the CN1371732A group
Conclusion: through laboratory observation of the present invention is shown, the present composition can strengthen the tolerance time (P＜0.01) of mice significantly, shortens the length of one's sleep (P＜0.01) of mice, has tangible statistical significance and dose-effect relationship.The present composition effect of relieving the effect of alcohol obviously is superior to CN1371732A group ((P＜0.01).The present composition has tangible antialcoholism action.
Test Example 2: the present composition is to the hepatoprotective effect of mice
1 material
The present composition; 56 ° of Red Star strong, colourless liquor distilled from sorghum, Beijing Red Star strong, colourless liquor distilled from sorghum brewery produces; The animal Kunming mouse, body weight 20～22g, male and female half and half.
2 methods
2.1 grouping administration: animal is divided into 3 groups at random, 10 every group.Each group is all fed with the mice standard feed, freely drinks water, and gets into experiment behind the nursing 3d.Model group is irritated stomach and is given wine 0.3ml//d, and feedwater 0.3ml/ only behind the 30min; Present composition group is given the same model group of capacity for liquor, only irritates stomach 0.3ml/ for behind the 30min present composition concentrated solution; The normal control group is irritated stomach feedwater, the same two groups of amount and time.Each group is fed environment facies together, and be 45d experimental period.
2.2 observation index and detection method:
2.2.1 body weight, activity situation reach reaction, survival rate to external irritant
2.2.2 alcohol concentration: behind 45d, get blood, irritate stomach and give 30min blood sampling after drinking from endocanthion.Detection method is: get the 0.1ml hemodilution to 5ml, get the 0.1ml sample introduction, detect the concentration of blood alcohol with chromatography of gases.
2.2.3 liver organization structural change: put to death behind the 45d, take out animal livers, fix with 10% formalin immediately, routine paraffin wax embedding, section 6mm, common HE dyeing, the variation of tissues observed structure under the light microscopic.
3 results
3.1 respectively organize body weight, survival rate, activity situation and to the variation of external irritant: during the experiment beginning, each organizes body weight does not have significant difference, model group lassitude behind the 20d, and present composition group changes slight.Model group, the normal matched group body weight of present composition group obviously alleviate behind the 45d, and model group obviously lightens than the present composition.Give after drinking every day, and walking appears in model group in 10min unstable, and balanced capacity descends, and can not climb cage, and extremity are overhanging, and breathing shoals, and bradykinesia is tired for sleeping in few moving, lethargy.Occur behind the present composition group above-mentioned symptom 20min, and symptom is more little, spirit, better movable, stimulating to external world has significant reaction, and can climb cage and ascend a height.
3.245d the survey Blood alcohol concentration, model group is apparently higher than present composition group (P＜0.01) (result sees table 1)
Table 1 respectively organize Mus survival rate, body weight change, BAC (
-X ± s)
Annotate: compare with model group: * P＜0.01; Compare with model group: * * P＜0.01
3.3 light microscopic is observed down the liver organization structural change: the normal control group with central vein (being filled with RBC) be the center liver cell plate basically it is thus clear that; Hepatocyte is taken out slightly and takes off phenomenon; The visible lobules of liver boundary of header not obvious (the lobules of liver connective tissue is few), the interlobar veins expansion is filled with RBC; Liver cell plate hepatocellular degeneration, necrosis around the model group part sublobular vein, karyopycnosis (engrain), karyorrhexis, the part sublobular vein is destroyed, and it is existing that hepatocyte has more little fat to ooze, and has apoptotic body to occur in the degeneration hepatocyte; Present composition group is basic identical with the normal control group, and visible few subregion becomes old downright bad, has normal liver cell to recover hypertrophy in the zone, does not have newborn necrotic zone.
Conclusion: show through experiment; The present composition has protective effect to the alcoholism mouse liver, has safeguarded hepatocellular normal configuration and metabolic function, has increased the metabolic rate of ethanol; Reduced the alcohol concentration in the blood; Improved the adaptability of the stress state of body, particularly central nervous system simultaneously, ethanol is alleviated central nervous system's inhibition or excitation.
Below come further to set forth preparation of compositions method according to the invention through embodiment.
Embodiment 1:
Radix Puerariae 15g, Concha Ostreae 15g, Rhizoma Imperatae 3g, Pericarpium Citri Reticulatae 3g, Radix Glycyrrhizae 2g, Mel powder 1.5g
Above-mentioned raw materials except that Mel powder, extracting in water 2 times, each 8 times of amounts were extracted 1.5 hours, filtered; Filtrating concentrates, and drying is pulverized, and adds Mel powder, adds sucralose 0.01g, citric acid 0.1g, maltose alcohol 5g; Mixing is used 90% alcohol granulation, drying, and packing promptly gets granule.
Embodiment 2:
Radix Puerariae 15g, Concha Ostreae 15g, Rhizoma Imperatae 3g, Pericarpium Citri Reticulatae 3g, Radix Glycyrrhizae 2g, Mel powder 1.5g
Above-mentioned raw materials except that Mel powder, extracting in water 2 times, each 8 times of amounts were extracted 1.5 hours, filtered, filtrating concentrates, drying is pulverized, and adds Mel powder, adds aspartame, citric acid, lactose, mixing, alcohol granulation, drying, packing promptly gets granule.
Embodiment 3:
Radix Puerariae 5g, Concha Ostreae 15g, Rhizoma Imperatae 3g, Pericarpium Citri Reticulatae 3g, Radix Glycyrrhizae 2g, Mel powder 1.5g, Spica Prunellae 5g, Radix Angelicae Dahuricae 5g
Above-mentioned raw materials except that Mel powder, extracting in water 2 times, each 8 times of amounts were extracted 1.5 hours, filtered; Filtrating concentrates, and drying is pulverized, and adds Mel powder, adds sucralose 0.01g, citric acid 0.1g, maltose alcohol 4g; Mixing is used 90% alcohol granulation, drying, and packing promptly gets granule.
Embodiment 4:
Radix Puerariae 5g, Concha Ostreae 15g, Rhizoma Imperatae 3g, Pericarpium Citri Reticulatae 3g, Radix Glycyrrhizae 2g, Mel powder 1.5g, Spica Prunellae 5g, Radix Angelicae Dahuricae 5g
Above-mentioned raw materials adds 8 times of water gagings and extracts 2 times except that Mel powder, and each 1.5 hours, filter, filtrating concentrates, and drying is pulverized, and adds Mel powder, adds cane sugar powder 5g, sucralose 0.01g, and mixing is used 90% alcohol granulation, drying, packing promptly gets granule.
Embodiment 5:
Radix Puerariae 10g, Concha Ostreae 10g, Rhizoma Imperatae 5g, Pericarpium Citri Reticulatae 5g, Radix Glycyrrhizae 3g, Mel powder 3g
Above-mentioned raw materials except that Mel powder, extracting in water 2 times, each 8 times of amounts were extracted 1.5 hours, filtered, filtrating concentrates, drying is pulverized, and adds Mel powder, adds adjuvant, mixing is granulated, drying incapsulates.
Embodiment 6:
Radix Puerariae 20g, Concha Ostreae 10g, Rhizoma Imperatae 1g, Pericarpium Citri Reticulatae 2g, Radix Glycyrrhizae 1g, Mel powder 1g
Above-mentioned raw materials except that Mel powder, extracting in water 2 times, each 8 times of amounts were extracted 1.5 hours, filtered, filtrating concentrates, drying is pulverized, and adds Mel powder, adds adjuvant, mixing is granulated, compacting in flakes.
Embodiment 7:
Radix Puerariae 3g, Concha Ostreae 20g, Rhizoma Imperatae 2g, Pericarpium Citri Reticulatae 1g, Radix Glycyrrhizae 5g, Mel powder 2g, Spica Prunellae 3g part, Radix Angelicae Dahuricae 8g
Above-mentioned raw materials except that Mel powder, extracting in water 2 times, each 8 times of amounts were extracted 1.5 hours, filtered, filtrating concentrates, drying is pulverized, and adds Mel powder, adds adjuvant, mixing is granulated, drying incapsulates.
Embodiment 8:
Radix Puerariae 10g, Concha Ostreae 10g, Rhizoma Imperatae 4g, Pericarpium Citri Reticulatae 4g, Radix Glycyrrhizae 4g, Mel powder 2g, Spica Prunellae 8g part, Radix Angelicae Dahuricae 3g
Above-mentioned raw materials except that Mel powder, extracting in water 2 times, each 8 times of amounts were extracted 1.5 hours, filtered, filtrating concentrates, drying is pulverized, and adds Mel powder, adds adjuvant, mixing is granulated, compacting in flakes.
Claims (7)
1. the compositions with effects of relieving alcoholism and protecting liver is characterized in that, its active component is processed by the following weight proportion raw material: Radix Puerariae 3-20 part, Concha Ostreae 10-20 part, Rhizoma Imperatae 1-5 part, Pericarpium Citri Reticulatae 1-5 part, Radix Glycyrrhizae 1-5 part, Mel powder 1-3 part.
2. according to the compositions of claim 1, it is characterized in that the consumption of its active component raw material is: 15 parts of Radix Puerariaes, 15 parts of Concha Ostreaes, 3 parts of Rhizoma Imperataes, 3 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 1.5 parts of Mel powder.
3. according to the compositions of claim 1, it is characterized in that wherein raw material also has: Spica Prunellae 3-8 part, Radix Angelicae Dahuricae 3-8 part.
4. according to the compositions of claim 3, it is characterized in that the consumption of its active component raw material is: 5 parts of Radix Puerariaes, 15 parts of Concha Ostreaes, 3 parts of Rhizoma Imperataes, 3 parts of Pericarpium Citri Reticulataes, 2 parts in Radix Glycyrrhizae, 1.5 parts of Mel powder, 5 parts of Spica Prunellaes, 5 parts of the Radixs Angelicae Dahuricae.
5. any described preparation of compositions method among the claim 1-4 is characterized in that this method is: get this compositions and respectively distinguish the flavor of raw material except that Mel powder; Extracting in water 1-3 time each 1-3 hour, filters; Filtrating concentrates, and drying is pulverized; Add Mel powder, add acceptable accessories and process clinical acceptable forms.
6. according to the method for preparing of claim 5, it is characterized in that this method is: get this compositions and respectively distinguish the flavor of raw material except that Mel powder, extracting in water 2 times, each 1.5 hours; Filter, filtrating concentrates, and drying is pulverized, and adds Mel powder; Add adjuvant, mixing is granulated, and drying promptly gets.
7. according to the method for preparing of claim 6, it is characterized in that this method is: get this compositions and respectively distinguish the flavor of raw material except that Mel powder, add 8 times of water gagings and extract 2 times; Each 1.5 hours, filter, filtrating concentrates, drying; Pulverize, add Mel powder, add 0.01 part of sucralose, 0.1 part of citric acid, maltose alcohol or cane sugar powder 4-5 part, mixing; Use 90% alcohol granulation, drying, packing promptly gets granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810239636A CN101745042B (en) | 2008-12-12 | 2008-12-12 | Composition with effects of relieving alcoholism and protecting liver and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810239636A CN101745042B (en) | 2008-12-12 | 2008-12-12 | Composition with effects of relieving alcoholism and protecting liver and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101745042A CN101745042A (en) | 2010-06-23 |
| CN101745042B true CN101745042B (en) | 2012-09-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200810239636A Expired - Fee Related CN101745042B (en) | 2008-12-12 | 2008-12-12 | Composition with effects of relieving alcoholism and protecting liver and preparation method thereof |
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| Country | Link |
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| CN (1) | CN101745042B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103584077B (en) * | 2012-08-14 | 2015-08-19 | 广西玉林制药集团巨安保健品有限公司 | A kind of composition of health food |
| CN103053765B (en) * | 2013-01-29 | 2013-11-27 | 时维静 | Preparation method of tea bag for alleviating hangover, helping digestion and protecting liver |
| CN103610803B (en) * | 2013-12-02 | 2016-07-13 | 广西麦克健丰制药有限公司 | A kind of liver-protecting and alcoholism-relieving Chinese medicine composition |
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2008
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| CN101745042A (en) | 2010-06-23 |
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