CN103610803B - A kind of liver-protecting and alcoholism-relieving Chinese medicine composition - Google Patents
A kind of liver-protecting and alcoholism-relieving Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a kind of liver-protecting and alcoholism-relieving Chinese medicine composition, be made up of the Chinese medicinal components of following weight portion: Radix Puerariae 40 50 parts, Herba Artemisiae Scopariae 20 25 parts, Fructus Momordicae 40 50 parts, Pericarpium Citri Reticulatae 50 58, Mentholum 0.5 1.5 parts.The present invention has clearing heat, detoxicating, dispelling dampness, depressed liver-energy dispersing and function of gallbladder promoting, invigorating the spleen and regulating the stomach QI invigorating, effect of liver-protecting and alcoholism-relieving relieving alcoholic intoxication, to the substantial amounts of patients such as the Nausea and vomiting of appearance, hypomnesis, absent minded, hepatic injury that drink, can liver-protecting and alcoholism-relieving quick, safe and effective.
Description
Technical field
The present invention relates to medicine, field of health care food, be specifically related to a kind of liver-protecting and alcoholism-relieving Chinese medicine composition.
Background technology
Wine, as one of maximum consumer goods of China, is favored by consumers in general.The health of appropriate useful human body of drinking,
But substantial amounts of drinking can cause Nausea and vomiting, hypomnesis, absent minded, even can be because of paralysis of respiratory muscle time serious
Cause death.Long-term alcohol can cause the diseases such as mental disorder, gastric ulcer and alcoholic liver, fatty liver, liver cirrhosis.The master of wine
Wanting composition is ethanol, and ethanol, after digestive tract absorbed into serum, arrives rapidly each portion of whole body, causes body Multisystem damage, as disappeared
Change system, nervous system, cardiovascular system etc..Liver is the major organs of alcohol metabolism, enters internal ethanol major part and exists
The final metabolism of liver is oxidized to carbon dioxide and water, discharges from lung, kidney, skin on a small quantity.Therefore, according to ethanol in human body
Absorption And Metabolism, exploitation efficient solution wine product is increasingly paid close attention to by society.
Chinese medicine has long history for the treatment of alcoholic liver disease, has rich experience and advantage in terms of medicine for treatment,
There is wide DEVELOPMENT PROSPECT.If application publication number is the Chinese invention patent of CN101716001A, disclose one and relieve the effect of alcohol and protect
Liver beverage and production method, formed by the raw material of following weight proportion: Radix Puerariae 15%, Herba Artemisiae Scopariae 10%, Flos puerariae lobatae 10%, Fructus Momordicae
10%, tamarind 10%, Fructus Aurantii 10%, long-pending chess piece 10}, Radix Glycyrrhizae 10%, Pericarpium Citri Reticulatae 15%, pectin 5%, Herba Menthae 3%, former
Expect through over cleaning, crush, soak, heat, filter, clarify, seasoning and adjusting incense, lower glue filter, sterilization filling makes finished product；
Have function of gallbladder promoting protect the liver, diuresis, suppression gastrointestinal absorption, the effect such as alcoholic intoxication；But this product is drink liquid preparation, it has not been convenient to take
Band.Application publication number is the Chinese invention patent of CN101972462A, discloses one and relieves the effect of alcohol removing dampness, replenishing QI to invigorate the spleen, circulation of qi promoting
The alcohol-neutralize healthy product of diuretic, by following component and the medicinal plants of ratio: Japanese raisintree fruit 20～60 parts, Flos puerariae lobatae (or Radix Puerariae) 20～50
Part, Flos Chrysanthemi 10～30 parts, Rhizoma Imperatae 5～20 parts, Semen Phaseoli 5～20 parts, Fructus Mume 5～10 parts, Rhizoma Zingiberis 5～10 parts, Fructus Crataegi 5～
20 parts, Fructus Hordei Germinatus (parched) 5～20 parts；Can also be added with: the Rhizoma Atractylodis Macrocephalae 5～10 parts；This formula is by compatibility, integrated use circulation of qi promoting,
Diuretic, qi-restoratives, stomach function regulating, the method such as be amusing, regulate function, and antialcoholism action is rapid, and effect is obvious.The present invention is directed to substantial amounts of
Drink the patients such as the Nausea and vomiting of appearance, hypomnesis, absent minded, hepatic injury, works out a kind of safe and effective
The Chinese medicine composition of liver-protecting and alcoholism-relieving, at present, there is not yet relevant report.
(1) Radix Puerariae, derives from the dry root into legume pueraria lobata Pueraria lobata (Willd.) Ohwi and (practises and claim " open country
Pueraria lobota ") or be the dry root of leguminous plant Radix Puerariae rattan Pueraria thomsonii Benth..
Radix Puerariae (is practised and is claimed " Herba Gelsemii Elegantis "): containing flavone compound 12%, it is mainly composed of isoflavonoid, and other also has
Triterpenes, Coumarins, organic acid etc..Osajin composition have daidzin (daidzin), daidzein (daidzein),
Puerarin (puerarin), daidzein-4,7-diglucoside, 7-xylose puerarin, 3'-hydroxypuerarin, Radix Ononis hircinae
Element etc.；Also have the triterpenes components and 6 such as sophoradiol, soyasapogenol A, B, 7-dimethoxy coumarin, Radix Puerariae coumarin etc..
Pachyrhizua angulatus: main starch-containing constituents.Additionally containing flavone compound, mainly there is a daiazi, daidzein, puerarin,
Daidzein 4 ', 7-diglucoside, 7-xyloside puerarin etc..Non-flavones ingredient has allantoin, cupreol, recklessly
Glucoraphenin, 6,7-dimethoxy coumarin, 5-methyl hydantoin, feather bean ketone and triterpene saponin etc..
(2) Herba Artemisiae Scopariae, for feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparia Waldst.et Kit. or Herba Artemisiae Scopariae
The dry aerial parts of Artemisiacapillaris Thunb..
Herba Artemisiae Scopariae contains following chemical composition: 1. Coumarins: Herba Artemisiae Scopariae contains 6,7-dimethoxy coumarin, scopoletin,
6-hydroxyl 7 methoxy coumarin and capillarin.2. chromogen ketone: Tarragon containing capillarisin, 7-methyl capillarisin,
4 '-methyl capillarisin and 6-de-methoxy-4 '-methyl capillarisin.The chromone of Herba Artemisiae Scopariae is except there being function of gallbladder promoting hepatoprotective effect
Outward, or antineoplastic effective composition.3. flavonoid: the old flavone of Herba Artemisiae Scopariae Halogen, different Artemisia anethoicles Mattf flavone and cirsimaritin, cirsimaritin
There is hepatoprotective effect, the most also there is certain anti-tumor activity.4. coumaric acid and other organic acid: Herba Artemisiae Scopariae is fragrant containing Herba Artemisiae Scopariae
Bean acid A, B and chlorogenic acid.It addition, Herba Artemisiae Scopariae is possibly together with acetylenic, monoterpenes and sesquiterpene volatile oil.
(3) Fructus Momordicae, for the dry fruit of cucurbitaceous plant Fructus Momordicae Momordica grosvenori Swingle.
Fructus Momordicae master contains triterpene saponin componds, flavone compound, protein, aminoacid, fructose, vitamin, fat
Acid and other trace element, wherein cucurbitane type tetracyclic triterpene saponin is the principle active component of Fructus Momordicae, always containing in dry fruit
Amount is 3.755%～3.858%, and the triterpenoid of research report the most has: siamenoside Ⅰ), Momordia grosvenori aglycone V, Fructus Momordicae
Glycosides II, mogroside ⅡE, mogroside Ⅲ, mogroside Ⅲ E, mogroside IV, 11-oxidation-Momordia grosvenori aglycone V, light fruit
Semen Momordicae saponin i, Momordia grosvenori aglycone A, Momordia grosvenori aglycone VI, the new glycosides of Fructus Momordicae, Fructus Momordicae glycol benzoate etc..Wherein arhat
Really glycosides V is the main sweet ingredient of Fructus Momordicae, and sugariness is 256～344 times of sucrose, is the natural sweetener of low-calorie, as
A kind of preferably health-care flavouring agent, is more suitable for overweight people and diabetes patient uses.
(4) Pericarpium Citri Reticulatae, for the drying and ripening fruit of rutaceae orange Citrus reticulata Blanco and variety thereof
Skin.
Mainly containing flavonoid and volatile oil component in Pericarpium Citri Reticulatae.Flavones ingredient has Hesperidin, neohesperidin, naringenin, 5-hydroxyl
-6,7,8,3,4 ,-pentamethoxyl flavone, 5,6,7,8,4 ,-pentamethoxyl flavone, 5,6,7,8,3,4 ,-hexa methoxy ketone etc..
Volatile oil content is 1.5～2.0%, and Pericarpium citri reticuatae chachiensis volatile oil content is 1.2～3.2%, and predominantly (Limonene accounts for limonene
80%).Additionally contain Neosynephrine, Nobiletin, 5-nor-dihydro Nobiletin, inositol and vitamin B1, C etc., more closely
Nian Laicong Pericarpium Citri Reticulatae proposes oxedrine.
(5) Mentholum, for a kind of saturated cyclic alcohol obtained in Oleum menthae, crystallizes or white for colourless needles or prism-shaped
Crystalline powder；There is the special aroma of Herba Menthae, refrigerant after taste is the scorchinggest hot.
Summary of the invention
It is an object of the invention to for the substantial amounts of Nausea and vomiting of appearance of drinking, hypomnesis, absent minded, liver damage
The patients such as wound, work out a kind of quick, Chinese medicine composition of safe and effective liver-protecting and alcoholism-relieving.
The technical solution adopted in the present invention is as follows:
A kind of liver-protecting and alcoholism-relieving Chinese medicine composition, is made up of the Chinese medicinal components of following weight portion: Radix Puerariae 40-50 part, Herba Artemisiae Scopariae 20-25
Part, Fructus Momordicae 40-50 part, Pericarpium Citri Reticulatae 50-58, Mentholum 0.5-1.5 part.
The above liver-protecting and alcoholism-relieving Chinese medicine composition, is preferably made up of the Chinese medicinal components of following weight portion: Radix Puerariae 45 parts, Herba Artemisiae Scopariae
23 parts, Fructus Momordicae 45 parts, Pericarpium Citri Reticulatae 52, Mentholum 1 part.
The above liver-protecting and alcoholism-relieving Chinese medicine composition, can be prepared as solid preparation or liquid preparation, such as medicine, health food,
On food allow preparation, such as: powder, granule, pill, tablet, capsule, decoction, soft extract, mixture, oral liquid,
Syrup, tea-drinking or chewable tablet, be preferably made chewable tablet.
Extraction is the committed step of preparation.The extraction of Effective Component of Chinese Medicine is a complicated process, when traditional Chinese medicine sample adds solvent
After, the chemical composition contained by Chinese medicine, by soaking diffusion, is gradually dissolved so that it is be diffused in solvent by solvent, until thin
The concentration of the chemical composition being dissolved in the outer solution of intracellular reaches balance.Therefore, during extracting, the Chinese medicine extraction time, secondary
Number, solvent etc., during extracting, the different Chinese medicine ingredients of dissolution react to each other, and are all the factors of impact extraction, select and close
The condition of reason, could improve the extraction ratio of effective ingredient, reach different using effects.
More than one described liver-protecting and alcoholism-relieving Chinese medicine compositions are prepared as the extracting method of preparation, comprise the following steps:
1. weigh Chinese medicinal components according to following weight portion: Radix Puerariae 40-50 part, Herba Artemisiae Scopariae 20-25 part, Fructus Momordicae 40-50 part, old
Skin 50-58, Mentholum 0.5-1.5 part；
2. taking Radix Puerariae and Herba Artemisiae Scopariae, boiling 3 times, each 1 hour, add 6 times amount water for the first time, second and third time respectively adds 4
Times amount water, decocting liquid filters, merging filtrate, is concentrated into relative density and is 1.18-1.22(60 DEG C) thick paste；
3. taking Fructus Momordicae boiling 4 times, each 1 hour, respectively add 6 times amount water, decocting liquid filters, and merging filtrate is dense
Contracting, be concentrated into relative density and be 1.20-1.25(60 DEG C) thick paste；
4. take tangerine peel powder and be broken into fine powder, cross 80 mesh sieves；
5. take Mentholum to be dissolved in 50% ethanol, obtain Mentholum solution.
The intermediate mixing that will obtain in aforementioned manners, adds the adjuvant needed, makes preparation.
The preparation method of more than one described liver-protecting and alcoholism-relieving Chinese medicine composition composition chewable tablets, including following operating procedure:
1. weigh Chinese medicinal components according to following weight portion: Radix Puerariae 40-50 part, Herba Artemisiae Scopariae 20-25 part, Fructus Momordicae 40-50 part, old
Skin 50-58, Mentholum 0.5-1.5 part；
2. taking Radix Puerariae and Herba Artemisiae Scopariae, boiling 3 times, each 1 hour, add 6 times amount water for the first time, second and third time respectively adds 4
Times amount water, decocting liquid filters, merging filtrate, is concentrated into relative density and is 1.18-1.22(60 DEG C) thick paste；
3. taking Fructus Momordicae boiling 4 times, each 1 hour, respectively add 6 times amount water, decocting liquid filters, and merging filtrate is dense
Contracting, be concentrated into relative density and be 1.20-1.25(60 DEG C) thick paste；
4. take tangerine peel powder and be broken into fine powder, excessively 80 mesh sieves, sterilizing, standby；Sucrose, mannitol are ground into fine powder, cross 80 mesh sieves,
Standby；
5. take Mentholum to be dissolved in 50% ethanol, obtain Mentholum solution；
6. take the thick paste of step 1 and the thick paste of step 2, add the tangerine peel powder of step 4, cane sugar powder and mannitol powder, mix,
Pelletize, be dried, granulate；Add the magnesium stearate of 2%, spray into the Mentholum solution of step 5 equably, mixing, granulate,
Tabletting, to obtain final product.
The above liver-protecting and alcoholism-relieving Chinese medicine composition makes the preparation method of chewable tablet, described sucrose, the weight of addition of mannitol
Amount percentage ratio is preferably 30-50%；Described sucrose is preferably 4:1-1:1 with the weight ratio of mannitol.
Radix Puerariae merit is kind brings down a fever, expelling pathogenic factors from muscles, promote the production of body fluid, relieve the effect of alcohol, for the key medicine relieved the effect of alcohol；Herba Artemisiae Scopariae energy clearing away heat-damp and promoting diuresis, function of gallbladder promoting, alcoholic liver
Damage mostly is damp and hot suffocating of liver and gall, uses two medicines to remove dampness-heat in the liver and gallbladder, and through modern pharmacological research, two taste medicines all have and protect the liver work
With, especially Herba Artemisiae Scopariae can substantially alleviate swelling of liver cell, the change of balloon sample, fat lesion with downright bad；Fructus Momordicae energy nourishing the lung to arrest cough,
Removing heat from blood, diuresis, effect of loosening bowel to relieve constipation, the traditional Chinese medical science is emphasized to cure the disease and to be used Fructus Momordicae that pathogenic factor can be allowed from defecation to evil with outlet
Get rid of；Heavy drinking is easily caused spleen injury, selects Pericarpium Citri Reticulatae invigorating the spleen and regulating the stomach QI invigorating in side；Herba Menthae brain-capacity vasoconstrictive promotes blood
Circulation, produces refrigerant sense, has refreshment of having one's ideas straightened out, sobering-up functions.Prescription of the present invention is rigorous, treating both the principal and secondary aspects of a disease, all medicines phase 5, can be clear
Thermal detoxification dampness removing, depressed liver-energy dispersing and function of gallbladder promoting, change addiction dredging collateral, invigorating the spleen and regulating the stomach QI invigorating, play the merit of liver-protecting and alcoholism-relieving relieving alcoholic intoxication altogether.
The Chinese medicinal components of Chinese medicine composition of the present invention is " integration of edible and medicinal herbs " kind, " Pueraria lobota in general side of Ministry of Health of the People's Republic of China
Root, Fructus Momordicae and Pericarpium Citri Reticulatae " it is classified as the list that second batch " is food and medicine ", Herba Artemisiae Scopariae is among the people to be commonly used to as vegetable edible use,
Mentholum is extracted by the leaf of Herba Menthae and stem, for the main component in Herba Menthae and lavender quintessence oil, is also conventional food additive,
Therefore, the Chinese medicine composition of liver-protecting and alcoholism-relieving of the present invention is safely and effectively.
The invention has the beneficial effects as follows:
(1) component is taken from " integration of edible and medicinal herbs " kind, can use as medicine and health food, safely and effectively.
2. prescription is rigorous, and the few power of medicine is special, has clearing heat, detoxicating, dispelling dampness, depressed liver-energy dispersing and function of gallbladder promoting, change addiction dredging collateral, invigorating the spleen and regulating the stomach QI invigorating, protects
Effect of liver Dealcoholic sobering-up, to substantial amounts of the drink Nausea and vomiting of appearance, hypomnesis, absent minded, hepatic injury
Deng patient, can liver-protecting and alcoholism-relieving relieving alcoholic intoxication quick, safe and effective.
3. the present invention sets extracting method according to the chemical composition of each taste Chinese medicine, and uses orthogonal method verification experimental verification: by Radix Puerariae and
Herba Artemisiae Scopariae is extracted together, and Fructus Momordicae separately extracts, and Pericarpium Citri Reticulatae uses protogenic medicinal powder, and Mentholum directly dissolves with 50% ethanol, can be by
Every the effective elements of the medicine extracts, extracting method science.
The most currently preferred dosage form chewable tablet, is convenient for carrying, and taking convenience is not required to water；Just swallowing after chewing, surface area increases
Greatly, can promote effective ingredient dissolving in vivo, drug-eluting is rapid, absorbs fast, and bioavailability is high；Abnormal smells from the patient is refrigerant, fragrant
Sweet good to eat, good patient compliance；Direct compression, production technology is simple, low cost.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but is not intended to protection scope of the present invention and range of application:
One, the preparation of liver-protecting and alcoholism-relieving Chinese medicine composition composition chewable tablet
Embodiment 1
A kind of preparation method of liver-protecting and alcoholism-relieving Chinese medicine composition composition chewable tablet, including following operating procedure:
1. weigh Chinese medicinal components according to following weight: Radix Puerariae 40kg, Herba Artemisiae Scopariae 20kg, Fructus Momordicae 40kg, Pericarpium Citri Reticulatae 50kg, thin
Lotus brain 0.5kg；
2. taking Radix Puerariae and Herba Artemisiae Scopariae, boiling 3 times, each 1 hour, add 6 times amount water for the first time, second and third time respectively adds 4
Times amount water, decocting liquid filters, merging filtrate, is concentrated into relative density and is 1.22(60 DEG C) thick paste；
3. taking Fructus Momordicae boiling 4 times, each 1 hour, respectively add 6 times amount water, decocting liquid filters, and merging filtrate is dense
Contracting, be concentrated into relative density and be 1.25(60 DEG C) thick paste；
4. take tangerine peel powder and be broken into fine powder, excessively 80 mesh sieves, sterilizing, standby；Sucrose, mannitol are ground into fine powder, cross 80 mesh sieves,
Standby；
5. take Mentholum to be dissolved in 50% ethanol, obtain Mentholum solution；
6. take the thick paste of step 1 and the thick paste of step 2, add the tangerine peel powder of step 4, cane sugar powder and mannitol powder (cane sugar powder
Being 30% with the percentage by weight of mannitol powder addition, sucrose is 1:1 with the weight ratio of mannitol) mix, pelletize, be dried,
Granulate；Add the magnesium stearate of 2%, spray into the Mentholum solution of step 5 equably, mixing, granulate, tabletting, to obtain final product.
The chewable tablet prepared is the brightest and the cleanest, and uniform color does not has sticking and sliver phenomenon；Abnormal smells from the patient is refrigerant, fragrant and sweet good to eat.
Embodiment 2
A kind of preparation method of liver-protecting and alcoholism-relieving Chinese medicine composition composition chewable tablet, including following operating procedure:
1. weigh Chinese medicinal components according to following weight: Radix Puerariae 50kg, Herba Artemisiae Scopariae 25kg, Fructus Momordicae 50kg, Pericarpium Citri Reticulatae 58kg, thin
Lotus brain 1.5kg；
2. taking Radix Puerariae and Herba Artemisiae Scopariae, boiling 3 times, each 1 hour, add 6 times amount water for the first time, second and third time respectively adds 4
Times amount water, decocting liquid filters, merging filtrate, is concentrated into relative density and is 1.18(60 DEG C) thick paste；
3. taking Fructus Momordicae boiling 4 times, each 1 hour, respectively add 6 times amount water, decocting liquid filters, and merging filtrate is dense
Contracting, be concentrated into relative density and be 1.20(60 DEG C) thick paste；
4. take tangerine peel powder and be broken into fine powder, excessively 80 mesh sieves, sterilizing, standby；Sucrose, mannitol are ground into fine powder, cross 80 mesh sieves,
Standby；
5. take Mentholum to be dissolved in 50% ethanol, obtain Mentholum solution；
6. take the thick paste of step 1 and the thick paste of step 2, add the tangerine peel powder of step 4, cane sugar powder and mannitol powder (cane sugar powder
Being 50% with the percentage by weight of mannitol powder addition, sucrose is 3:1 with the weight ratio of mannitol) mix, pelletize, be dried,
Granulate；Add the magnesium stearate of 2%, spray into the Mentholum solution of step 5 equably, mixing, granulate, tabletting, to obtain final product.
The chewable tablet prepared is the brightest and the cleanest, and uniform color does not has sticking and sliver phenomenon；Abnormal smells from the patient is refrigerant, fragrant and sweet good to eat.
Embodiment 3
A kind of preparation method of liver-protecting and alcoholism-relieving Chinese medicine composition composition chewable tablet, including following operating procedure:
1. weigh Chinese medicinal components according to following weight: Radix Puerariae 45kg, Herba Artemisiae Scopariae 23kg, Fructus Momordicae 45kg, Pericarpium Citri Reticulatae 52kg, Herba Menthae
Brain 1kg；
2. taking Radix Puerariae and Herba Artemisiae Scopariae, boiling 3 times, each 1 hour, add 6 times amount water for the first time, second and third time respectively adds 4
Times amount water, decocting liquid filters, merging filtrate, is concentrated into relative density and is 1.20(60 DEG C) thick paste；
3. taking Fructus Momordicae boiling 4 times, each 1 hour, respectively add 6 times amount water, decocting liquid filters, and merging filtrate is dense
Contracting, be concentrated into relative density and be 1.22(60 DEG C) thick paste；
4. take tangerine peel powder and be broken into fine powder, excessively 80 mesh sieves, sterilizing, standby；Sucrose, mannitol are ground into fine powder, cross 80 mesh sieves,
Standby；
5. take Mentholum to be dissolved in 50% ethanol, obtain Mentholum solution；
6. take the thick paste of step 1 and the thick paste of step 2, add the tangerine peel powder of step 4, cane sugar powder and mannitol powder (cane sugar powder
Being 40% with the percentage by weight of mannitol powder addition, sucrose is 4:1 with the weight ratio of mannitol) mix, pelletize, be dried,
Granulate；Add the magnesium stearate of 2%, spray into the Mentholum solution of step 5 equably, mixing, granulate, tabletting, to obtain final product.
The chewable tablet prepared is the brightest and the cleanest, and uniform color does not has sticking and sliver phenomenon；Abnormal smells from the patient is refrigerant, fragrant and sweet good to eat.
Two, pharmacodynamics test
1. test material: the above-mentioned embodiment 1-3 sample prepared；Ethanol, selects the Red Star strong, colourless liquor distilled from sorghum Chinese liquor of 55 °.
2. animal: healthy mice 50, male, 6-8 week old, body weight 30 ± 2g, with normal diet feed, freely drink water with
Feed.
3. animal packet: mice is randomly divided into 5 groups (often groups 10), i.e. blank group, model control group, embodiment 1
Group, embodiment 2 groups, embodiment 3 groups.
Blank group feeds normal saline；Model group feeds Red Star strong, colourless liquor distilled from sorghum Chinese liquor (1.45g/kg) of 55 °；Embodiment 1-3 group is first divided
Not Wei embodiment 1-3 sample (6g/kg), feed Red Star strong, colourless liquor distilled from sorghum Chinese liquor (1.45g/kg) of 55 ° after 1 hour again.
4. detection method: after feeding 4 weeks, employing is won eyeball and taken blood, separates serum cryopreservation to be checked.
5. result of the test:
(1) ordinary circumstance is observed: blank group hair is glossy, and figure is active, and sensitivity is good, and appetite and stool are normal,
Body weight all increases 5g；Embodiment 1-3 group hair relatively gloss, figure is relatively active, and sensitivity is preferable, and appetite and stool are normal, body
Weight average increases 3g；Model control group hair luster degree is poor, and figure is slower, and sensitivity is poor, and appetite is few, defecates diluter, body
Weight average increases 1g.
(2) Serum ALT, AST, GGT compare: refer to following table, model control group and the Serum ALT of embodiment group, AST,
GGT is apparently higher than blank group (P 0.01)；Embodiment group compared with model control group, can significantly reduce Serum ALT, AST,
GGT level (P 0.01).
Respectively organize Serum ALT, AST, GGT(x ± s, U/L)
6. conclusion: the enzyme that ALT, AST, GGT are discharged after destroyed by hepatocyte, this test is by mice serum
The mensuration of the representative enzyme of ALT, AST, GGT, can reflect inflammation or the necrotic lesion of liver system, by above-mentioned test,
Result shows: the present invention can effectively reduce mice serum ALT, AST, GGT；The prompting present invention can improve histanoxia environment,
Reduce body internal oxidition free radical to produce and lipid peroxidation, antiendotoxin and oxidation resistance in reinforcement, improve cell
Membrane stability, protects hepatocyte, effect protected to alcoholic liver injury, toxic reaction does not occurs.
Three, clinical practice
Liver-protecting and alcoholism-relieving Chinese medicine composition of the present invention, is once used for treating and observe 65 example patient or volunteers.By the above-mentioned reality prepared
Execute example 3 chewable tablet, for the Nausea and vomiting caused because of heavy drinking, hypomnesis, absent minded, hepatic injury
Deng.Usage and dosage: each 3, chew clothes；Take before drinking or after drinking.Result: crapulent above-mentioned after taking
Symptom has bigger alleviation, and effective percentage reaches 78%, has no adverse reaction.
Claims (7)
1. a liver-protecting and alcoholism-relieving Chinese medicine composition, it is characterised in that be made up of the Chinese medicinal components of following weight portion: Radix Puerariae 40-50 part, Herba Artemisiae Scopariae 20-25 part, Fructus Momordicae 40-50 part, Pericarpium Citri Reticulatae 50-58, Mentholum 0.5-1.5 part.
Liver-protecting and alcoholism-relieving Chinese medicine composition the most according to claim 1, it is characterised in that be made up of the Chinese medicinal components of following weight portion: Radix Puerariae 45 parts, Herba Artemisiae Scopariae 23 parts, Fructus Momordicae 45 parts, Pericarpium Citri Reticulatae 52, Mentholum 1 part.
Liver-protecting and alcoholism-relieving Chinese medicine composition the most according to claim 1 or claim 2, it is characterised in that described Chinese medicine composition makes powder, granule, pill, tablet, capsule, decoction, soft extract, mixture, oral liquid, syrup, tea-drinking or chewable tablet.
4. liver-protecting and alcoholism-relieving Chinese medicine composition as claimed in claim 3 is prepared as an extracting method for preparation, comprises the following steps:
(1) Chinese medicinal components is weighed according to following weight portion: Radix Puerariae 40-50 part, Herba Artemisiae Scopariae 20-25 part, Fructus Momordicae 40-50 part, Pericarpium Citri Reticulatae 50-58, Mentholum 0.5-1.5 part；
(2) taking Radix Puerariae and Herba Artemisiae Scopariae, boiling 3 times, each 1 hour, add 6 times amount water for the first time, second and third time respectively adds 4 times amount water, and decocting liquid filters, and merging filtrate is concentrated into relative density and is 1.18-1.22(60 DEG C) thick paste；
(3) taking Fructus Momordicae boiling 4 times, each 1 hour, respectively add 6 times amount water, decocting liquid filters, merging filtrate, concentrates, is concentrated into relative density and is 1.20-1.25(60 DEG C) thick paste；
(4) take tangerine peel powder and be broken into fine powder, excessively 80 mesh sieves, sterilizing, standby；
(5) take Mentholum to be dissolved in 50% ethanol, obtain Mentholum solution.
5. a liver-protecting and alcoholism-relieving Chinese medicine composition extracting method as claimed in claim 4 makes the preparation method of chewable tablet, it is characterised in that also include following operating procedure: take sucrose, mannitol is ground into fine powder, crosses 80 mesh sieves, standby；Take thick paste and the thick paste of step (2) of step (1), add tangerine peel powder, cane sugar powder and the mannitol powder of step (4), mixing, pelletize, be dried, granulate；Add the magnesium stearate of 2%, spray into the Mentholum solution of step (5) equably, mixing, granulate, tabletting, to obtain final product.
The most according to claim 5, liver-protecting and alcoholism-relieving Chinese medicine composition makes the preparation method of chewable tablet, it is characterised in that described sucrose, the percentage by weight of addition of mannitol are 30-50%.
The most according to claim 6, liver-protecting and alcoholism-relieving Chinese medicine composition makes the preparation method of chewable tablet, it is characterised in that described sucrose is 4:1-1:1 with the weight ratio of mannitol.
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| CN111297963A (en) * | 2020-04-10 | 2020-06-19 | 广东轻工职业技术学院 | Extract and composition for dispelling effects of alcohol and protecting liver as well as preparation method and application of extract and composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106267063A (en) * | 2016-07-26 | 2017-01-04 | 张韩 | A kind of Chinese medicine composition protecting stomach liver-protecting and alcoholism-relieving and preparation method thereof |
| CN106474380A (en) * | 2016-12-19 | 2017-03-08 | 广州市协裕中药科技有限公司 | There is Chinese medicine composition, preparation of liver-protecting and alcoholism-relieving effect and preparation method thereof |
| CN106620357A (en) * | 2017-02-17 | 2017-05-10 | 福建康是美生物科技有限公司 | Alcohol effect dispelling and liver protecting traditional Chinese medicinal composition containing tea polyphenol |
| CN107137487A (en) * | 2017-05-27 | 2017-09-08 | 江西中医药大学 | Draft relieving alcoholism and protecting liver effervescent tablet with anti-alcoholic function and sobering-up function and preparation method thereof |
| CN113262209A (en) * | 2021-03-04 | 2021-08-17 | 湖北中医药大学 | Alcohol-dispelling and liver-protecting chewing candy and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101716001A (en) * | 2009-12-07 | 2010-06-02 | 周文兴 | Anti-alcohol and liver-protection beverage and production method thereof |
| CN101745042A (en) * | 2008-12-12 | 2010-06-23 | 北京宝德润生医药科技发展有限公司 | Composition with effects of relieving alcoholism and protecting liver and preparation method thereof |
| CN102526481A (en) * | 2012-01-19 | 2012-07-04 | 漳州瑞祥堂生物科技有限公司 | Anoectochilus formosanus compound oral solution for relieving alcoholism and protecting liver and preparation method thereof |
| CN103285217A (en) * | 2013-06-14 | 2013-09-11 | 袁军清 | Traditional Chinese medicine for soothing liver and detoxifying |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101036883B1 (en) * | 2008-09-26 | 2011-05-25 | (주)복앤복 | Health beverage composition comprising Swellfish extracts and preparation method thereof |
-
2013
- 2013-12-02 CN CN201310638630.7A patent/CN103610803B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101745042A (en) * | 2008-12-12 | 2010-06-23 | 北京宝德润生医药科技发展有限公司 | Composition with effects of relieving alcoholism and protecting liver and preparation method thereof |
| CN101716001A (en) * | 2009-12-07 | 2010-06-02 | 周文兴 | Anti-alcohol and liver-protection beverage and production method thereof |
| CN102526481A (en) * | 2012-01-19 | 2012-07-04 | 漳州瑞祥堂生物科技有限公司 | Anoectochilus formosanus compound oral solution for relieving alcoholism and protecting liver and preparation method thereof |
| CN103285217A (en) * | 2013-06-14 | 2013-09-11 | 袁军清 | Traditional Chinese medicine for soothing liver and detoxifying |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111297963A (en) * | 2020-04-10 | 2020-06-19 | 广东轻工职业技术学院 | Extract and composition for dispelling effects of alcohol and protecting liver as well as preparation method and application of extract and composition |
| CN111297963B (en) * | 2020-04-10 | 2021-11-26 | 广东轻工职业技术学院 | Extract and composition for dispelling effects of alcohol and protecting liver as well as preparation method and application of extract and composition |
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