CN102526481A - Anoectochilus formosanus compound oral solution for relieving alcoholism and protecting liver and preparation method thereof - Google Patents
Anoectochilus formosanus compound oral solution for relieving alcoholism and protecting liver and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a compound oral solution for relieving alcoholism and protecting the liver and a preparation method thereof, in particular to an anoectochilus formosanus compound oral solution for relieving alcoholism and protecting the liver and a preparation method thereof. The oral solution comprises the following components in proportion by weight: 50-65% of anoectochilus formosanus, 5-10% of wild chrysanthemum flower, 4-10% of white peony root, 4-10% of dried rehmannia root, 5-10% of flower of kudzuvine, 5-10% of sealwort, 3-6% of glehnia root, 2-5% of southernwood, 2-6% of ebony and 1-3% of liquorice. The preparation method comprises the steps of extracting, mixing, concentrating, clarifying, correcting, roughly filtering, finely filtering, sealing, sterilizing and packing finished products. The compound oral solution has a pure traditional Chinese medicine combination, a scientific prescription and an advanced process, and the product has obvious functions of relieving alcoholism and protecting the liver, can obviously relieve headache, dizziness, sleepiness, asthenia, thirst, vomit, fantod and other symptoms caused by insobriety or drunkenness, has the health care preventive functions of soothing the liver and strengthening the spleen, restoring consciousness and soothing the nerves, clearing away heat and toxic material, and invigorating qi and nourishing the blood, and also has the characteristics of good taste and flavor and taking convenience.
Description
Technical field
The present invention relates to a kind of compound sobering-up and protect the liver oral liquid and preparation method thereof, more specifically relate to Herba Anoectochili roxburghii compound recipe liver-protecting sobering up oral liquid and preparation method thereof.
Technical background
China is a country of advocating spirits culture; When various commercial affairs, ceremony and party, often can not keep from drink, insobriety or drunk frequent generation have brought numerous social problems; Had a strong impact on people's health; Existing in the market many antialcoholic medicines and health protection products, but be single antialcoholism function mostly, insobriety or the drunk hepar damnification that causes are not worked the function of preventing and protecting; Hepatoprotective is very necessary before and after drinking, and just possibly avoid or alleviate the injury that wine causes human body when relieving the effect of alcohol like this.China is one of hepatopathy country occurred frequently simultaneously; The light hepatitis B patient whole nation just has more than 100,000,000; Therefore how prevention of liver disease or the liver protecting are one of problems of extremely annotating of people in modern, the existing medicines and health protection product that much protects the liver on the market, but different formulations liver protective effect difference is very big.
Summary of the invention
It is that the main Herba Anoectochili roxburghii compound sobering-up with Antialcoholic liver-protecting, soothing liver and strengthening spleen protects the liver oral liquid and preparation method thereof with the Herba Anoectochili roxburghii that the object of the invention is to provide a kind of.
Herba Anoectochili roxburghii compound sobering-up of the present invention protects the liver oral liquid, it is characterized in that: its prescription compatibility comprises: Herba Anoectochili roxburghii, Flos Chrysanthemi Indici, the Radix Paeoniae Alba, Radix Rehmanniae, Flos puerariae lobatae, Rhizoma Polygonati, Radix Glehniae, Herba Artemisiae Annuae, Fructus Mume, Radix Glycyrrhizae, and the parts by weight compatibility of wherein said each prescription is than being (total umber is 100): Herba Anoectochili roxburghii 50-65%; Flos Chrysanthemi Indici 5-10%, Radix Paeoniae Alba 4-10%, Radix Rehmanniae 4-10%; Flos puerariae lobatae 5-10%, Rhizoma Polygonati 5-10%, Radix Glehniae 3-6%; Herba Artemisiae Annuae 2-5%, Fructus Mume 2-6%, Radix Glycyrrhizae 1-3%.
Herba Anoectochili roxburghii compound sobering-up of the present invention protects the liver oral liquid, its preparation method:
Technological process is lixiviate → mixing → concentrated → clarification → strong flavor → coarse filtration → fine straining → packing → sealing → antibacterial → decals → coding → packing → finished product.Concrete steps are following:
⑴, lixiviate: the 60%-90% alcohol reflux that Herba Anoectochili roxburghii, the Radix Paeoniae Alba and Radix Rehmanniae medicament bulking value 4-8 doubly measure 0.5-1.5 hour; Collect ethanol extract a; And then the medicament bulking value 4-8 drinking water hot water backflow lixiviate of doubly measuring 2-3 time; Temperature 85-95 ℃, each 0.5-1.5 hour, collect extracting solution b; The drinking water that Flos Chrysanthemi Indici, Flos puerariae lobatae, Rhizoma Polygonati, Radix Glehniae, Herba Artemisiae Annuae, Fructus Mume and Radix Glycyrrhizae adding drug weight volume 4-8 doubly measure decocts 2-3 time, each 0.5-1.5 hour, temperature 85-95 ℃, collects extracting solution c;
⑵, mixing and concentrated: extracting solution a, b and the c of step ⑴ are mixed, concentrate;
⑶, clarification: add that to account for the concentrated solution weight ratio be the chitosan of 0.03-0.05% and the EDTA of 0.5-1.0% in the concentrated solution, leave standstill 20-30min after the stirring;
⑷, rectify flavor: the clarification back is added and is accounted for glycyrrhizic acid that the compound weight ratio is 0.02-0.05% and the stevioside of 0.03-0.05% carries out seasoning; It is colour fixative that interpolation accounts for sodium D-isoascorbate, the 0.01-0.02% sorbic acid that the compound weight ratio is 0.01-0.03%;
⑸, will clarify, rectify liquid material behind the flavor through coarse filtration and fine straining, sealing, antibacterial are packaged as finished product then.
The concentrated employing 60000Da ultrafilter membrane of step (2) concentrates under 40-60 ℃, pressure 0.30-0.40MP.Extracting solution is concentrated into prescribed volume, processes the ratio of oral liquid 100ml in 40 g Chinese medicines.
The said coarse filtration of step (5) adopts 300 order filter clothes to carry out coarse filtration.
The said fine straining of step (5) adopts the 4000Da ultrafilter membrane under 40-50 ℃, pressure 0.10-0.20MP, to carry out fine straining.Instantaneous ultrahigh-temperature sterilization (UHT), sterilizing time 10-15s, 125 ± 1 ℃ of sterilization temperatures are adopted in the said antibacterial of step (5).
Pharmacological action of the present invention: the present invention adopts the Chinese crude drug of each above-mentioned prescription compatibility to prepare, based on:
Herba Anoectochili roxburghii: sweet, flat; Return lung, liver, kidney, urinary bladder channel; Clearing away heat and cooling blood, expelling wind and removing dampness are used for nephritis, cystitis, diabetes, bronchus, rheumatic arthritis, acute infantile convulsion etc.;
Flos Chrysanthemi Indici: bitter, hot, be slightly cold; Return liver, heart channel; Heat-clearing and toxic substances removing, the pathogenic fire purging suppressing the hyperactive liver is used for the furuncle carbuncle, conjunctival congestion and swelling pain, it is dizzy to have a headache;
The Radix Paeoniae Alba: bitter, sour, be slightly cold; Return liver, spleen channel; Nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG, it is dizzy to be used for blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, headache;
Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting are used for heat and go into nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin and hinder constipation, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, interior-heat and quench one's thirst;
Flos puerariae lobatae: sweet, flat; Return spleen, stomach warp; Relieving acute alcoholism and recuperating the spleen, clearing away heat-damp and promoting diuresis are used for damage of the spleen and stomach caused by alcoholism, anorexia, vomiting acid regurgitation;
Rhizoma Polygonati: sweet, flat; Return spleen, lung, kidney channel; Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying are used for deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, chronic cough hemoptysis, asthenia of essence and blood, soreness of the waist and knees, early whitening of beard and hair, interior-heat and quench one's thirst;
Radix Glehniae: sweet, little hardship is slightly cold; Attach to the lung and stomach meridians; Nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid are used for lung-heat type cough, chronic cough expectorant blood, deficiency of stomach-Yin, calentura Tianjin wound, dry throat and mouth;
Herba Artemisiae Annuae: bitter, hot, cold; Return liver, gallbladder meridian; Clearind deficient heat, remove hectic fever due to YIN-deficiency, separate summer-heat, preventing the attack (or recurrence) of malaria, jaundice eliminating, be used for pathogenic warmth impairment of YIN, night fever abating at dawn, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, pathogenic summer-heat heating, malaria cold and heat, jaundice due to damp-heat;
Fructus Mume: sour, puckery, flat; Return liver, spleen, lung, large intestine channel; Astringe the lung, astringing intestine to stop diarrhea, promote the production of body fluid, relieving colic caused by ascaris, be used for that chronic cough of deficiency lung, chronic diarrhea chronic dysentery, deficiency-heat are quenched one's thirst, ascariasis of biliary tract vomiting stomachache;
Radix Glycyrrhizae: sweet, flat; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription are used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Advantage of the present invention: the object of the invention is to use tradition and modern Chinese medicine theory; According to the result of study of Herba Anoectochili roxburghii modern pharmacology pharmacodynamics, with pure drug matching, scientific composition; Advanced technologies; Developing with the Herba Anoectochili roxburghii is that main compound sobering-up protects the liver oral liquid, and this product not only has significant Antialcoholic liver-protecting function, obviously alleviates because of insobriety or the drunk headache that causes, dizziness, drowsiness, weak, thirsty, vomiting, symptom such as fidgety; And have the health care prophylactic function of soothing liver and strengthening spleen, refreshment and tranquilization, heat-clearing and toxic substances removing, benefiting QI and nourishing blood, also have simultaneously that taste flavor is all good, the characteristics of taking convenience.
The specific embodiment
Below be several instantiation of the present invention, further describe the present invention, but the present invention be not limited only to this.
Instance 1:
Prescription: be by weight: Herba Anoectochili roxburghii 50%, Flos Chrysanthemi Indici 9%, the Radix Paeoniae Alba 9%, Radix Rehmanniae 7%, Flos puerariae lobatae 9%, Rhizoma Polygonati 5%, Radix Glehniae 4%, Herba Artemisiae Annuae 3%, Fructus Mume 3%, Radix Glycyrrhizae 1%.
⑴, lixiviate: with Herba Anoectochili roxburghii, the Radix Paeoniae Alba and Radix Rehmanniae 90% (volume ratio with 4 times of amounts (w/v is like g/ml, down together) of aforementioned three kinds of drug weight volumes; Down together) alcohol reflux is 0.5 hour; Collect ethanol extract a, the drinking water hot water backflow lixiviate of 4 times of amounts of the aforementioned three kinds of drug weight volumes of medicinal residues reuse that obtain 2 times, 95 ℃ of temperature; Each 1.5 hours, collect extracting solution b; Flos Chrysanthemi Indici, Flos puerariae lobatae, Rhizoma Polygonati, Radix Glehniae, Herba Artemisiae Annuae, Fructus Canarii albi and the Radix Glycyrrhizae drinking water with 8 times of amounts of aforementioned seven kinds of drug weight volumes is decocted 2 times, and each 0.5 hour, 95 ℃ of temperature were collected extracting solution c.
⑵, mixing and concentrated: extracting solution a, b and the c of step ⑴ are mixed, adopt the 60000Da ultrafilter membrane to concentrate, concentrate, be concentrated into prescribed volume (processing the ratio of oral liquid 100ml in 40 g Chinese medicines) at 60 ℃ of pressure 0.30MP.
⑶, clarification: add that to account for the concentrate feed weight ratio be 0.03% chitosan and 1.0% EDTA in the concentrated solution, leave standstill 20min after the stirring.
⑷, rectify flavor: the clarification back adds that to account for the compound weight ratio be that 0.02% glycyrrhizic acid and 0.05% stevioside carry out seasoning; Add that to account for the compound weight ratio be that 0.02% sodium D-isoascorbate, 0.01% sorbic acid are colour fixative.
⑸, will clarify, rectify liquid material behind the flavor through coarse filtration and fine straining, sealing, antibacterial are packaged as finished product then, adopt 300 order filter clothes to carry out coarse filtration; Adopt the 4000Da ultrafilter membrane under 45 ℃, pressure 0.15MP, to carry out fine straining; Adopt instantaneous ultrahigh-temperature sterilization (UHT), sterilizing time 15s, 124 ℃ of sterilization temperatures.
Instance 2:
Prescription: be by weight: Herba Anoectochili roxburghii 60%, Flos Chrysanthemi Indici 6%, the Radix Paeoniae Alba 6%, Radix Rehmanniae 5%, Flos puerariae lobatae 5%, Rhizoma Polygonati 6%, Radix Glehniae 3%, Herba Artemisiae Annuae 5%, Fructus Mume 2%, Radix Glycyrrhizae 2%.
⑴, lixiviate: with Herba Anoectochili roxburghii, the Radix Paeoniae Alba and Radix Rehmanniae with 75% alcohol reflux of 6 times of amounts of aforementioned three kinds of drug weight volumes 1 hour; Collect ethanol extract a; The drinking water hot water backflow lixiviate of 6 times of amounts of the aforementioned three kinds of drug weight volumes of medicinal residues reuse that obtain 2 times; 90 ℃ of temperature each 1 hour, are collected extracting solution b; Flos Chrysanthemi Indici, Flos puerariae lobatae, Rhizoma Polygonati, Radix Glehniae, Herba Artemisiae Annuae, Fructus Mume and the Radix Glycyrrhizae drinking water with 6 times of amounts of aforementioned seven kinds of drug weight volumes is decocted 2 times, and each 1 hour, 90 ℃ of temperature were collected extracting solution c.
⑵, mixing and concentrated: extracting solution a, b and the c of step ⑴ are mixed, adopt the 60000Da ultrafilter membrane to concentrate, concentrate, be concentrated into prescribed volume (processing the ratio of oral liquid 100ml in 40 g Chinese medicines) at 50 ℃ of pressure 0.35MP.
⑶, clarification: add that to account for the concentrate feed weight ratio be 0.05% chitosan and 0.5% EDTA in the concentrated solution, leave standstill 25min after the stirring.
⑷, rectify flavor: the clarification back adds that to account for the compound weight ratio be that 0.03% glycyrrhizic acid and 0.04% stevioside carry out seasoning; Add that to account for the compound weight ratio be that 0.03% sodium D-isoascorbate, 0.01% sorbic acid are colour fixative.
⑸, will clarify, rectify liquid material behind the flavor through coarse filtration and fine straining, sealing, antibacterial are packaged as finished product then,
Coarse filtration adopts 300 order filter clothes to carry out coarse filtration; Fine straining adopts the 4000Da ultrafilter membrane under 40 ℃, pressure 0.20MP, to carry out fine straining; Instantaneous ultrahigh-temperature sterilization (UHT), sterilizing time 10s, 126 ℃ of sterilization temperatures are adopted in antibacterial.
Instance 3:
Prescription: be by weight: Herba Anoectochili roxburghii 65%, Flos Chrysanthemi Indici 5%, the Radix Paeoniae Alba 4%, Radix Rehmanniae 4%, Flos puerariae lobatae 6%, Rhizoma Polygonati 7%, Radix Glehniae 3%, Herba Artemisiae Annuae 3%, Fructus Mume 2%, Radix Glycyrrhizae 1%.
⑴, lixiviate: with Herba Anoectochili roxburghii, the Radix Paeoniae Alba and Radix Rehmanniae with 60% alcohol reflux of 8 times of amounts of aforementioned three kinds of drug weight volumes 1.5 hours; Collect ethanol extract a; The drinking water hot water backflow lixiviate of 6 times of amounts of the aforementioned three kinds of drug weight volumes of medicinal residues reuse that obtain 2 times; 85 ℃ of temperature each 0.5 hour, are collected extracting solution b; Flos Chrysanthemi Indici, Flos puerariae lobatae, Rhizoma Polygonati, Radix Glehniae, Herba Artemisiae Annuae, Fructus Mume and the Radix Glycyrrhizae drinking water with 4 times of amounts of aforementioned seven kinds of drug weight volumes is decocted 2 times, and each 1.5 hours, 85 ℃ of temperature were collected extracting solution c.
⑵, mixing and concentrated: extracting solution a, b and the c of step ⑴ are mixed, adopt the 60000Da ultrafilter membrane to concentrate, concentrate, be concentrated into prescribed volume (processing the ratio of oral liquid 100ml in 40 g Chinese medicines) at 40 ℃ of pressure 0.40MP.
⑶, clarification: add that to account for the concentrate feed weight ratio be 0.04% chitosan and 0.8% EDTA in the concentrated solution, leave standstill 25min after the stirring.
⑷, rectify flavor: the clarification back adds that to account for the compound weight ratio be that 0.05% glycyrrhizic acid and 0.03% stevioside carry out seasoning; Add that to account for the compound weight ratio be that 0.01% sodium D-isoascorbate, 0.02% sorbic acid are colour fixative.
⑸, will clarify, rectify liquid material behind the flavor through coarse filtration and fine straining, sealing, antibacterial are packaged as finished product then,
Coarse filtration adopts 300 order filter clothes to carry out coarse filtration; Fine straining adopts the 4000Da ultrafilter membrane under 50 ℃, pressure 1.20MP, to carry out fine straining; Instantaneous ultrahigh-temperature sterilization (UHT), sterilizing time 12s, 125 ℃ of sterilization temperatures are adopted in antibacterial.
Clinical effectiveness of the present invention
⑴, Herba Anoectochili roxburghii compound sobering-up protect the liver the drunk test of prevention of oral liquid
Choose 90 of SPF level Male Kunming strain mice, be divided into A, B, a C3 processed group at random, each handles 3 repetitions, and each repeats 10, and each is organized mice and feeds with standard feed, freely drinks water, and adaptability is fed the back entering test of 1 week.Each treated animal fasting 8h before the experiment;, giving distilled water (0.5ml/ is only) by different groups difference perfusion A groups (matched group), B (extra large Wang Jin cup group) gives extra large Wang Jin cup medicinal liquid, and (0.5ml/ is only; Extra large Wang Jin cup sheet is dissolved in the distilled water; Process medicinal liquid, liquor strength is 9g/100ml), C (the Herba Anoectochili roxburghii compound sobering-up protects the liver the oral liquid group) gives the Herba Anoectochili roxburghii compound sobering-up and protects the liver oral liquid (0.5ml/ only, Chinese crude drug 40 g process the 100ml oral liquid by technology); Behind 45 min, each treated animal gives 5O% alcoholic solution (15 ml/kg).Observe mice from irritating wine to drunk situation.Whether drunk whether the disappearance with righting reflex is index to mice, keeps the above person of the downward posture 30S in back to think drunk, and record is respectively organized the drunk quantity of mice and gone into the liquor-saturated time.
Table 1 Herba Anoectochili roxburghii compound sobering-up protects the liver the drunk test of prevention of oral liquid
Annotate: 1, lower case be illustrated in P significant difference on the O.O5 level. and capitalization be illustrated in P significant difference on the level O.01,
2, extra large Wang Jin cup sheet is the alcohol-neutralize healthy product that Wang Jiankang development in science and technology company limited in sea, Shenzhen is produced
The result shows, before giving wine, gives the Herba Anoectochili roxburghii compound sobering-up earlier and protects the liver oral liquid, can obviously reduce the quantity of drunk mice, but significant prolongation is gone into the liquor-saturated time simultaneously, and prevents drunk effect obviously to be superior to extra large Wang Jin cup sheet.
⑵, Herba Anoectochili roxburghii compound sobering-up protect the liver the test of sobering up of oral liquid
Test is divided into groups with ［ 1 ］ item; All animal fasting 12 h before the experiment; Each treated animal gives the drunk situation that 5O% alcoholic solution (15 ml/kg) is observed mice; Whether drunk standard is the same for mice; In case mice drunk is immediately by the perfusion respectively of different groups, A group (matched group) gives distilled water (0.5ml/ only), and B (extra large Wang Jin cup group) gives extra large Wang Jin cup medicinal liquid (0.5ml/ only), C (the Herba Anoectochili roxburghii compound sobering-up protects the liver the oral liquid group) gives the Herba Anoectochili roxburghii compound sobering-up and protects the liver oral liquid (0.5ml/ only).Observe the situation of sobering up of mice, all sober up until all animals.Whether whether mice sobers up reverts to index with righting reflex.Record mice righting reflex loss time (drunk time), sober up the time (time that mice righting reflex loss to righting reflex recovers) and drunk number of animals.
Table 2 Herba Anoectochili roxburghii compound sobering-up protects the liver the test of sobering up of oral liquid
Annotate: lower case be illustrated in P significant difference on the O.O5 level. capitalization is illustrated in P < significant difference on the level O.01
The result shows, gives the Herba Anoectochili roxburghii compound sobering-up after drunk to protect the liver oral liquid, and can significantly shorten wakes up gets drunk the wine time, and sober up effect obviously is superior to extra large Wang Jin cup drunk-sobering tablet.
⑵, Herba Anoectochili roxburghii compound sobering-up protect the liver the protective effect of oral liquid acute liver damage
Choose 40 of SPF level male mice in kunming, be divided into 4 groups at random: A group (blank group), B group (hepatic injury matched group), C group (extra large Wang Jin cup group), D organize (the Herba Anoectochili roxburghii compound sobering-up protects the liver the oral liquid group), 12 every group.Each is organized mice and feeds with standard feed, freely drinks water, and adaptability is fed the back entering test of 1 week.Respectively organize mice fasting 8 h before the experiment, A, B group give distilled water (0.5ml/ only), and C, D group mice give extra large Wang Jin cup medicinal liquid by 0.5ml/ dosage filling stomach respectively and the Herba Anoectochili roxburghii compound sobering-up protects the liver the oral liquid group.After irritating stomach 45 min, except that A group mice gives the distilled water, other is respectively organized mice and gives 50% alcoholic solution by the dosage of 15 ml/kg.Ethanol is won mouse liver after irritating stomach 12 h, processes 10% LH, measures malonaldehyde (MDA), reduced glutathion (GSH) and serum triglycerides (TG) content in the hepatic tissue.The mensuration of serum triglycerides adopts phosphoglycerol oxidase peroxidase method, and MDA measures and adopts T team colorimetry, GSH to measure employing DTNB colorimetry.
Table 3 Herba Anoectochili roxburghii compound sobering-up protects the liver the influence of oral liquid to murine liver tissue GSH, MDA and serum TG
Annotate: lower case be illustrated in P significant difference on the O.O5 level. capitalization is illustrated in P < significant difference on the level O.01
The result shows: the Herba Anoectochili roxburghii compound sobering-up protects the liver oral liquid can significantly reduce MDA content in the murine liver tissue that ethanol causes; Significantly improve GSH content in the hepatic tissue; The rising of the serum TG content that significantly suppresses to cause by ethanol; Explain that the Herba Anoectochili roxburghii compound sobering-up protects the liver the acute liver damage that oral liquid causes ethanol and has the significant protection effect, same Herba Anoectochili roxburghii compound sobering-up protects the liver acute liver damage that oral liquid causes ethanol to have the significant protection effect and is superior to extra large Wang Jin cup sheet.
Claims (7)
1. a Herba Anoectochili roxburghii compound sobering-up protects the liver oral liquid, it is characterized in that: the raw material of being processed active ingredient by the weight meter consists of: Herba Anoectochili roxburghii 50-65%, Flos Chrysanthemi Indici 5-10%; Radix Paeoniae Alba 4-10%, Radix Rehmanniae 4-10%, Flos puerariae lobatae 5-10%; Rhizoma Polygonati 5-10%, Radix Glehniae 3-6%, Herba Artemisiae Annuae 2-5%; Fructus Mume 2-6%, Radix Glycyrrhizae 1-3%, above-mentioned percentage ratio summation is 100%.
2. a Herba Anoectochili roxburghii compound sobering-up as claimed in claim 1 protects the liver the method for preparing of oral liquid, and it is characterized in that: said method for preparing may further comprise the steps:
⑴, lixiviate: the 60%-90% alcohol reflux that Herba Anoectochili roxburghii, the Radix Paeoniae Alba and Radix Rehmanniae medicament bulking value 4-8 doubly measure 0.5-1.5 hour; Collect ethanol extract a; And then the medicament bulking value 4-8 drinking water hot water backflow lixiviate of doubly measuring 2-3 time; Temperature 85-95 ℃, each 0.5-1.5 hour, collect extracting solution b; The drinking water that Flos Chrysanthemi Indici, Flos puerariae lobatae, Rhizoma Polygonati, Radix Glehniae, Herba Artemisiae Annuae, Fructus Mume and Radix Glycyrrhizae adding drug weight volume 4-8 doubly measure decocts 2-3 time, each 0.5-1.5 hour, temperature 85-95 ℃, collects extracting solution c;
⑵, mixing and concentrated: extracting solution a, b and the c of step ⑴ are mixed, concentrate;
⑶, clarification: add that to account for the concentrated solution weight ratio be the chitosan of 0.03-0.05% and the EDTA of 0.5-1.0% in the concentrated solution, leave standstill 20-30min after the stirring;
⑷, rectify flavor: the clarification back is added and is accounted for glycyrrhizic acid that the compound weight ratio is 0.02-0.05% and the stevioside of 0.03-0.05% carries out seasoning; It is colour fixative that interpolation accounts for sodium D-isoascorbate, the 0.01-0.02% sorbic acid that the compound weight ratio is 0.01-0.03%;
⑸, will clarify, rectify liquid material behind the flavor through coarse filtration and fine straining, sealing, antibacterial are packaged as finished product then.
3. the method for preparing of Herba Anoectochili roxburghii compound sobering-up liver protecting capsule according to claim 2 is characterized in that: the concentrated employing 60000Da ultrafilter membrane of step (2) concentrates under 40-60 ℃, pressure 0.30-0.40MP.
4. the method for preparing of Herba Anoectochili roxburghii compound sobering-up liver protecting capsule according to claim 2 is characterized in that: the said coarse filtration of step (5) adopts 300 order filter clothes to carry out coarse filtration.
5. the method for preparing of Herba Anoectochili roxburghii compound sobering-up liver protecting capsule according to claim 2 is characterized in that: the said fine straining of step (5) adopts the 4000Da ultrafilter membrane under 40-50 ℃, pressure 0.10-0.20MP, to carry out fine straining.
6. the method for preparing of Herba Anoectochili roxburghii compound sobering-up liver protecting capsule according to claim 2 is characterized in that: instantaneous ultrahigh-temperature sterilization UHT, sterilizing time 10-15s, 125 ± 1 ℃ of sterilization temperatures are adopted in the said antibacterial of step (5).
7. the method for preparing of Herba Anoectochili roxburghii compound sobering-up liver protecting capsule according to claim 2 is characterized in that: step is concentrated into prescribed volume with extracting solution in (2), processes the ratio of oral liquid 100ml in 40 g Chinese medicines.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103202377A (en) * | 2013-03-22 | 2013-07-17 | 安徽华佗国药股份有限公司 | Qinggan tea (for alcoholic liver and fatty liver) and making method thereof |
| CN103610803A (en) * | 2013-12-02 | 2014-03-05 | 广西健丰药业有限公司 | Traditional Chinese medicine composition for protecting liver and dispelling effects of alcohol |
| CN103918829A (en) * | 2013-01-15 | 2014-07-16 | 漳州美利德生物工程有限公司 | Making method of Anoectochilus formosanus tea |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103918829A (en) * | 2013-01-15 | 2014-07-16 | 漳州美利德生物工程有限公司 | Making method of Anoectochilus formosanus tea |
| CN103918829B (en) * | 2013-01-15 | 2015-10-28 | 漳州美利德生物工程有限公司 | Roxburgh anoectochilus terminal bud tea preparation method |
| CN103202377A (en) * | 2013-03-22 | 2013-07-17 | 安徽华佗国药股份有限公司 | Qinggan tea (for alcoholic liver and fatty liver) and making method thereof |
| CN103610803A (en) * | 2013-12-02 | 2014-03-05 | 广西健丰药业有限公司 | Traditional Chinese medicine composition for protecting liver and dispelling effects of alcohol |
| CN103610803B (en) * | 2013-12-02 | 2016-07-13 | 广西麦克健丰制药有限公司 | A kind of liver-protecting and alcoholism-relieving Chinese medicine composition |
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| CN102526481B (en) | 2013-09-11 |
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