CN105031301A - Anti-tumor traditional Chinese medicine composition and preparation method thereof - Google Patents
Anti-tumor traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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- CN105031301A CN105031301A CN201510528657.XA CN201510528657A CN105031301A CN 105031301 A CN105031301 A CN 105031301A CN 201510528657 A CN201510528657 A CN 201510528657A CN 105031301 A CN105031301 A CN 105031301A
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Abstract
The invention relates to an anti-tumor traditional Chinese medicine composition and a preparation method thereof. The anti-tumor traditional Chinese medicine composition comprises the following components in parts by weight: 15-50 parts of dendrobium officinale, 5-25 parts of ganoderma lucidum extract, 5-20 parts of astragalus root extract, and 5-15 parts of Chinese wolfberry extract. The anti-tumor traditional Chinese medicine composition is prepared by compounding the dendrobium officinale, ganoderma lucidum extract, astragalus root extract and wolfberry fruit extract as raw materials in appropriate proportions, and the four components are nutrient substances with different molecular structures, have partial same drug effects and respective obvious drug effects and are organically combined according to appropriate proportions, so that curative effects are mutually complemented and promoted, respective effects are exerted to the utmost extent, and the corresponding cost can be reduced. The anti-tumor traditional Chinese medicine composition provided by the invention conforms to the 'assistant and guide' principle of the prescription in the traditional Chinese medicine, and is rigorous in prescription and proper in compatibility of medicines.
Description
Technical field
The invention belongs to antitumor drug technical field, particularly relate to a kind of antitumor Chinese and preparation method thereof.
Background technology
Tumor be body under various carcinogenic factor effect, some cells of local organization lose the normal regulation to its growth on gene level, and causing its clonal abnormality hypertrophy and the neoplasm that formed, is one of principal disease of current harm humans health.In the past few years, the number of tumor and cancer is died from every year up to 7,000,000 in the whole world, and tumor and cancer has become the disease causing death toll maximum in the world.Great demand space is there is in current Global Medicine market to safe and effective antitumor drug.The most basic biological property of tumor is unregulated cell growth, finds the important topic that the antineoplastic agent having a targeted inhibition effect to growth of tumour cell is medicament research and development person.
Modern medicine treats tumor with chemotherapy, radiotherapy and operation for main, but a large amount of clinical treatments proves the toxic and side effects be also attended by while chemotherapy and radiation in various degree, also can anti-personnel normal cell to a great extent while killing tumor, bring vomiting, weak, diarrhoea, leukopenia, tissue edema, neural paralysis, tissue necrosis etc. to human body.The advantages such as Traditional Chinese Medicine Anti tumor has mechanism of action uniqueness, lasting medicine, Mutiple Targets, multipath, Antitumor test is wide, toxic and side effects is little, for treatment tumor, there is huge potentiality and irreplaceable advantage, nowadays progressively occupy leading position clinically.
Summary of the invention
The invention provides a kind of antitumor Chinese and preparation method thereof, to solve the problems of the technologies described above.
In order to achieve the above object, technical scheme of the present invention is achieved in that a kind of antitumor Chinese, counts by weight, comprising: Herba Dendrobii 20-50 part; Ganoderma extract 5-25 part; Radix Astragali extract 5-20 part; Wolfberry fruit extract 5-15 part.
In above-mentioned technical characteristic, count by weight, comprising: Herba Dendrobii 45 parts; Ganoderma extract 22 parts; Radix Astragali extract 18 parts; Wolfberry fruit extract 13 parts.
In above-mentioned technical characteristic, count by weight, comprising: Herba Dendrobii 20 parts; Ganoderma extract 25 parts; Radix Astragali extract 5 parts; Wolfberry fruit extract 5 parts.
In above-mentioned technical characteristic, the dosage form of described antitumor Chinese is capsule or tablet.
In above-mentioned technical characteristic, described Ganoderma extract is take Ganoderma sporophore as raw material by Ganoderma extract powder obtained after concentrated and lyophilization after supercritical carbon dioxide extraction method.
In above-mentioned technical characteristic, described Radix Astragali extract is that raw material is by astragalus extraction medicinal powder obtained after water/alcohol extracting, centrifugalize, microfiltration separation, ultra-filtration and separation, nanofiltration separation, lyophilization with the Radix Astragali.
In above-mentioned technical characteristic, described wolfberry fruit extract is that raw material is by wolfberry fruit extract powder obtained after hot-water extraction, concentrating under reduced pressure and lyophilization with Fructus Lycii.
A preparation method for antitumor Chinese, comprises the following steps:
(1) according to weight parts, Herba Dendrobii 15-50 part is taken; Ganoderma extract 5-25 part; Radix Astragali extract 5-20 part; Wolfberry fruit extract 5-15 part puts into the broken dispersal mechanism of compound high shear force for nanometer powder;
(2) powder mixed in step 1 is proceeded to ultrasonic mixer, ultrasonic mixing was refrigerated to-20 DEG C after 25 minutes;
(3) under 4 DEG C of conditions by the powder mix homogeneously in step 2;
(4) finished product is made after the powder in step 3 being crossed 120 mesh sieves.
In above-mentioned technical characteristic, the powder after sieving is added in tablet machine to make tablet or be filled in capsule make capsule in step 4.
The present invention's various raw material effects used are as follows:
Ganoderma extract comprises the principle active component such as ganoderma lucidum triterpene compounds and ganoderan, overcome the determination that traditional Ganoderma can not make human body fully absorb comprehensively its nutritional labeling and utilize, cause waste and the loss of ganoderma lucidum composition, its nutritional labeling can fully be absorbed by human body comprehensively and utilize.Ganoderma extract has significant antitumor and immunostimulation, enhance the anti-tumor capacity of macrophage and T-cell, this is because the antitumor cell factor (signal agency) secretion that ganoderan induction produces is risen, i.e. TNF-alpha and IFN-gamma, and these two kinds of cytokines are show cooperative effect at suppression leukemic cell growth.Ganoderan can unlimited, the quick splitting ability of inhibition tumor cell, and at present, ganoderan has been used as one of medicine for the treatment of tumor; Ganoderan also has raising immunity of organisms, improves body's hypoxia tolerance, hypoglycemic activity, effect for reducing blood fat, anti-radiation and anti-aging effects.
Herba Dendrobii has effect of nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, clearing away heat to improve acuity of vision, tonifying five ZANG-organs asthenia.All be widely used in the auxiliary treatment, chronic gastritis, diabetes, chronic pharyngitis, weakness due to chronic disease immunologic hypofunction, eye health etc. of malignant tumor.Herba Dendrobii in the treatment of malignant tumor, on the one hand because the luxuriant and rich with fragrance class material chrysotoxene (chrysotoxene) contained by it and EN (erianin) have obvious active anticancer; On the other hand because its polysaccharide composition can significantly increase cellular immune function and humoral immune function.Strengthen monokaryon one macrophage phagocytic function.Thus effectively auxiliary therapeutic action can be played to the immunocompromised patient that clinical tumor Radiotherapy chemotherapy patient and a variety of causes cause.Experimentation proves that Herba Dendrobii also has fine blood sugar decreasing effect.Because of antioxidation and the immunoloregulation function of iron sheet, therefore mid-aged population is had to effect of enhancing human body immunity power, antidotal health care.
Radix Astragali extract comprises the plurality of active ingredients such as polysaccharide and soaping agents, these active component all have enhancing antibody to generate and immunoreactive effect, can be used as immunopotentiating agent or regulator, there is the effects such as antiviral, antitumor, defying age, radioprotective, anti-stress, antioxidation simultaneously.Astragalus polysaccharides is one of main active of the Radix Astragali, has blood fat reducing, namely reduces the effect of cholesterol and triglyceride, high density lipoprotein increasing; Can prevention and therapy cardiovascular and cerebrovascular disease, as atherosclerosis, coronary artery pathological changes, peripheral angiopathy and hyperlipemia etc.
The main component of wolfberry fruit extract is lycium barbarum polysaccharide, is a kind of water soluble polysaccharide, and its primary efficacy is nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Facilitation is had to immunity, there is immunoregulation effect: can plasma testosterone level be improved simultaneously, play strong effect: have facilitation to hemopoietic function: also have remarkable effect in increasing leukocyte to normal healthy people: also have defying age, mutation, antitumor, blood fat reducing, protect the liver and anti-fatty liver, blood sugar lowering, hypotensive activity.
Compared with prior art, the invention has the advantages that: the present invention forms for primary raw material is composite with Herba Dendrobii, Ganoderma extract, Radix Astragali extract, Fructus Lycii extract etc., suitable ratio is selected to share, they are the different nutrient substance of molecular structure, there is the identical drug effect of part and drug effect outstanding separately, each component organically combines according to proper proportion, not only mutually can supplement in curative effect and mutually promote, play respective effect to greatest extent, and corresponding cost can be reduced; Be rich in the principle active component such as abundanter ganoderan, triterpenes Ganodenic acid than Common ganoderma lucidum in Ganoderma extract, the producing level of Ganoderma composition is higher, and health-care effect is more remarkable; Herba Dendrobii is in the treatment of malignant tumor, on the one hand because the luxuriant and rich with fragrance class material chrysotoxene (chrysotoxene) contained by it and EN (erianin) have obvious active anticancer, on the other hand because its polysaccharide composition can significantly increase cellular immune function and humoral immune function, strengthen monokaryon one macrophage phagocytic function, effectively auxiliary therapeutic action can be played to the immunocompromised patient that clinical tumor Radiotherapy chemotherapy patient and a variety of causes cause; Radix Astragali extract can be used as immunopotentiating agent or regulator, has the effects such as antiviral, antitumor, defying age, radioprotective, anti-stress, antioxidation simultaneously; Wolfberry fruit extract has facilitation to immunity, there is immunoregulation effect: can plasma testosterone level be improved simultaneously, play strong effect: have facilitation to hemopoietic function: also have remarkable effect in increasing leukocyte to normal healthy people: also have defying age, mutation, antitumor, blood fat reducing, protect the liver and anti-fatty liver, blood sugar lowering, hypotensive activity.
Detailed description of the invention
Chinese medicine formula compositions of the present invention meet tcm prescription prescription " monarch " principle of being particular about, prescription is rigorous, compatibility is proper, meet the Therapeutic Principle of Chinese traditional treatment tumor " hard masses should be resolved gradually ", " disease caused by accumulations of pathogen should be treated with therapy of dispersion ", " disease with retention of pathogen in the body should be treated by elimination therapy ", " treatment of deficiency-syndrome by reinforcement ", use this Chinese medicine formula compositions to treat tumor and in theory there is feasibility.
Carry out clear, complete description below with reference to specific embodiment to technical scheme of the present invention, obviously, described embodiment is only a part of embodiment of the present invention, instead of whole embodiments.Based on the embodiment in the present invention, other embodiments all that those of ordinary skill in the art obtain under the prerequisite not making creative work, all belong to the scope that the present invention protects.
Embodiment 1
A kind of antitumor Chinese, counting crude drug is by weight: Herba Dendrobii 45 parts; Ganoderma extract 22 parts; Radix Astragali extract 18 parts; Wolfberry fruit extract 13 parts.
(1) method specified according to dendrobium polysaccharide under assay item in " Chinese Pharmacopoeia " (2010 editions) first " Herba Dendrobii " measures, and it is about 30% that result records dendrobium polysaccharide content.
(2) method specified according to ganoderan under assay item in " Chinese Pharmacopoeia " (2005 editions) first " Ganoderma " measures, and it is about 15% that result records ganoderma polyoses content.
(3) measure according to the Methods for Determination of Astraglus Polysaccharides specified in " veterinary medical quality standard " (2003 editions) Radix Astragali injection, it is about 35% that result records Radix Astragali extract polyoses content.
(4) method specified according to Lycium barbarum polysaccharides under assay item in " Chinese Pharmacopoeia " (2005 editions) first " Fructus Lycii " measures, and it is about 12% that result records Lycium barbarum polysaccharides content.
(5) according to Guangdong Province's provincial standard of Administration of Quality and Technology Supervision of Guangdong Province approval project verification---the content of method to triterpene substance of the mensuration of triterpene substance " in the Ganoderma " measures, and it is about 1.0% that result records ganoderma lucidum triterpene content of material.
Preferably, the dosage form of antitumor Chinese is capsule or tablet.
Preferably, Ganoderma extract is take Ganoderma sporophore as raw material by Ganoderma extract powder obtained after concentrated and lyophilization after supercritical carbon dioxide extraction method.
Preferably, Radix Astragali extract is that raw material is by astragalus extraction medicinal powder obtained after water/alcohol extracting, centrifugalize, microfiltration separation, ultra-filtration and separation, nanofiltration separation, lyophilization with the Radix Astragali.
Preferably, wolfberry fruit extract is that raw material is by wolfberry fruit extract powder obtained after hot-water extraction, concentrating under reduced pressure and lyophilization with Fructus Lycii.
The method for preparing tablet thereof of above-mentioned antitumor Chinese, comprises the following steps:
(1) according to weight parts, Herba Dendrobii 45 parts is taken; Ganoderma extract 22 parts; Radix Astragali extract 18 parts; Wolfberry fruit extract 13 parts puts into the broken dispersal mechanism of compound high shear force for nanometer powder;
(2) powder mixed in step 1 is proceeded to ultrasonic mixer, ultrasonic mixing was refrigerated to-20 DEG C after 25 minutes;
(3) under 4 DEG C of conditions by the powder mix homogeneously in step 2;
(4) finished product is made after the powder in step 3 being crossed 120 mesh sieves.
Preferably, the powder after sieving in step 4 is added in tablet machine to make tablet or be filled in capsule make capsule.
Embodiment 2
A kind of antitumor Chinese, counting crude drug is by weight: Herba Dendrobii 30 parts; Ganoderma extract 15 parts; Radix Astragali extract 12 parts; Wolfberry fruit extract 10 parts.
Its preparation method is identical with embodiment 1.
Embodiment 3
A kind of antitumor Chinese, counting crude drug is by weight: Herba Dendrobii 20 parts; Ganoderma extract 25 parts; Radix Astragali extract 5 parts; Wolfberry fruit extract 5 parts.
Its preparation method is identical with embodiment 1.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, any those skilled in the art, do not departing within the scope of technical solution of the present invention, make a little change when the technology contents of above-mentioned announcement can be utilized or be modified to the Equivalent embodiments of equivalent variations, in every case be the content not departing from technical solution of the present invention, the any simple modification done above embodiment according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (9)
1. an antitumor Chinese, is characterized in that, counts by weight, comprising: Herba Dendrobii 20-50 part; Ganoderma extract 5-25 part; Radix Astragali extract 5-20 part; Wolfberry fruit extract 5-15 part.
2. antitumor Chinese as claimed in claim 1, is characterized in that: count by weight, comprising: Herba Dendrobii 45 parts; Ganoderma extract 22 parts; Radix Astragali extract 18 parts; Wolfberry fruit extract 13 parts.
3. antitumor Chinese as claimed in claim 1, is characterized in that: count by weight, comprising: Herba Dendrobii 20 parts; Ganoderma extract 25 parts; Radix Astragali extract 5 parts; Wolfberry fruit extract 5 parts.
4. antitumor Chinese as claimed in claim 1, is characterized in that: the dosage form of described antitumor Chinese is capsule or tablet.
5. the antitumor Chinese as described in as arbitrary in claim 1-4, is characterized in that: described Ganoderma extract is take Ganoderma sporophore as raw material by Ganoderma extract powder obtained after concentrated and lyophilization after supercritical carbon dioxide extraction method.
6. the antitumor Chinese as described in as arbitrary in claim 1-4, is characterized in that: described Radix Astragali extract is that raw material is by astragalus extraction medicinal powder obtained after water/alcohol extracting, centrifugalize, microfiltration separation, ultra-filtration and separation, nanofiltration separation, lyophilization with the Radix Astragali.
7. the antitumor Chinese as described in claim 1-4, is characterized in that: described wolfberry fruit extract is that raw material is by wolfberry fruit extract powder obtained after hot-water extraction, concentrating under reduced pressure and lyophilization with Fructus Lycii.
8. a preparation method for antitumor Chinese, is characterized in that: comprise the following steps:
(1) according to weight parts, Herba Dendrobii 15-50 part is taken; Ganoderma extract 5-25 part; Radix Astragali extract 5-20 part; Wolfberry fruit extract 5-15 part puts into the broken dispersal mechanism of compound high shear force for nanometer powder;
(2) powder mixed in step 1 is proceeded to ultrasonic mixer, ultrasonic mixing was refrigerated to-20 DEG C after 25 minutes;
(3) under 4 DEG C of conditions by the powder mix homogeneously in step 2;
(4) finished product is made after the powder in step 3 being crossed 120 mesh sieves.
9. the preparation method of antitumor Chinese as claimed in claim 8, is characterized in that: added in tablet machine to make tablet or be filled in capsule by the powder after sieving in step 4 and make capsule.
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| CN110859800A (en) * | 2019-11-11 | 2020-03-06 | 李利 | Oral liquid for preventing cancer and resisting aging and preparation method thereof |
| CN111494555A (en) * | 2020-05-14 | 2020-08-07 | 安徽至开医药生物科技有限公司 | A Chinese medicinal composition used as both medicine and food for improving immunity, and its preparation method |
| CN111686207A (en) * | 2020-06-19 | 2020-09-22 | 杭州医学院 | Dendrobium devonianum compound preparation and preparation method and application thereof |
| CN112022897A (en) * | 2020-10-10 | 2020-12-04 | 邓述才 | A Chinese medicinal composition for preventing cancer, and its preparation method |
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| CN112022897A (en) * | 2020-10-10 | 2020-12-04 | 邓述才 | A Chinese medicinal composition for preventing cancer, and its preparation method |
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