CN101869695B - Medicinal composition for improving immunity and application thereof - Google Patents
Medicinal composition for improving immunity and application thereof Download PDFInfo
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- CN101869695B CN101869695B CN2010101525140A CN201010152514A CN101869695B CN 101869695 B CN101869695 B CN 101869695B CN 2010101525140 A CN2010101525140 A CN 2010101525140A CN 201010152514 A CN201010152514 A CN 201010152514A CN 101869695 B CN101869695 B CN 101869695B
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Abstract
The invention discloses a medicinal composition and application thereof. The medicinal composition has an effect on improving the immunity of people with low body immune function and sub-health, and is particularly used for improving the immunity of patients with a long illness, the patients with body weakness after illness, the patients with tumors and the patients after radiation treatment and chemotherapy; and simultaneously the medicinal composition has health effects on strengthening body, deferring senility, caring skin and nourishing the skin of healthy population.
Description
Affiliated technical field
The invention belongs to the health care technology field, be specifically related to a kind of health medicine compositions and application thereof that improves immunity.
Background technology
Modern society is along with the variation of living environment, the quickening of rhythm of life, over-drastic mentality, physical work, psychentonia etc. make people more and more feel the body resistance ability drop, and therefore " hypoimmunity ", " subhealth state " also become the health problem of social concerns gradually.It is too fast that the most direct performance of so-called hypoimmunity is exactly that human body energy consumes, and has a delicate constitution, performances such as tired sleepy, easy catching a cold, listlessness, appetite depression, sensation of oppression over the chest with shortness of breath, sore waist and aching in the waist and the back, insomnia, senilism.If things go on like this can cause health and intelligence development bad, also easily bring out major disease, for example cardiovascular and cerebrovascular disease, diabetes, hypertension, hyperlipemia, fatty liver, obesity etc., even cancer.So the immune function of human body imbalance can't neglect.Modern immunology thinks that immunity is the defense mechanism of human body self, is human body identification and any foreign body (virus, antibacterial etc.) of eliminating external intrusion; Handle the ability of self cell and identification and the processing vivo mutations cell and the virus infected cell of old and feeble, damage, dead, degeneration.The present invention will provide a kind of pharmaceutical composition that can improve immunity.Said composition can be prepared into medicine, the health product of various dosage forms, can also make the better health drink of mouthfeel.
This pharmaceutical composition comprises Ganoderma, Fructus Momordicae, Semen Ginkgo, Fructus Lycii, Rhizoma Zingiberis Recens 5 herbal medicines.Wherein Ganoderma is regarded as strengthening by means of tonics always, consolidates the precious Chinese herbal medicine of setting upright.The folklore Ganoderma have come back to life, effect alive for evermore.Shennong's Herbal is classified Ganoderma as top grade, and the meaning Ganoderma " main deaf, sharp joint, the refreshing benefit of guarantor is smart, hard muscles and bones, good color is obeyed to make light of one's life by commiting suicide for a long time and is not prolonged life always." " invigorating middle warmer increases wisdom not to be forgotten the meaning Ganoderma lucidum (Leyss. Ex Fr.) Karst. for main knot in the heart, the beneficial motive, and food of a specified duration is made light of one's life by commiting suicide not old, prolongs life and becomes an immortal." Ganoderma, sweet in the mouth, property is flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Ganoderma is two-ways regulation function of human body balance on the whole, transfers the internal body vigor, regulates human body metabolism function, improves the autoimmune ability, is monarch drug.Fructus Momordicae is described as " angle fruit ", and sweet in the mouth, acid are cool in nature, can clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, the liver benefiting spleen invigorating, the cough-relieving of promoting the production of body fluid, laxation toxin expelling, skin care benefit face, moistening the lung and resolving phlegm, but life prolonging, the happy color of preserving youthful looks also has anticancer effect.The auxiliary Ganoderma of this product is improved the human righteousness, and the grow fraud of being bored with few with the Ganoderma sour and sweet drugs can transforme into YIN is ministerial drug.Semen Ginkgo claims Semen Ginkgo again, and property is flat, and the sweet in the mouth bitterness is slightly poisonous; Go into lung, kidney channel.Astringing lung QI for relieving asthma is arranged, the effect of leukorrhagia stopping reducing urination.Compendium of Material Medica: " go into that lung meridian, strengthening the spleen gas, Dingchuan are coughed, urine reducing." have a natural health effect, long-term edible can slow down aging, life prolonging.Fructus Lycii, its sweet in the mouth, property are put down.Return liver, kidney channel.Nourishing the liver and kidney is arranged, and the effect of replenishing vital essence to improve eyesight says in the Compendium of Material Medica that " obey hard muscles and bones for a long time, it is not old to make light of one's life by commiting suicide, cold-resistant summer-heat." modern pharmacological research confirms Fructus Lycii scalable body's immunity, can effectively suppress tumor cell, slow down aging.Semen Ginkgo and Fructus Lycii two medicines share, and can set upright to consolidate by principal drug assistance, can strengthen the merit that ministerial drug nourishing lung and kidney, skin care are lengthened the life again, are adjuvant drug altogether.Rhizoma Zingiberis Recens acrid in the mouth, slightly warm in nature are returned lung, spleen, stomach warp.Expelling cold and relieving exterior syndrome, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing; Energy solving toxin of fish and crab, poison of drug.Have in the Compendium of Material Medica: " give birth to dispersing, ripe usefulness with in." record, supplement to the Herbal opinion Rhizoma Zingiberis Recens: " juice antidote, removing blood stasis removes cold old expectorant in transferring, appetizing ".The Rhizoma Zingiberis Recens slightly warm in nature can be in harmonious proportion the cool in nature of Fructus Momordicae, warming middle-JIAO for easing the stomach; Also can separate the mild toxicity of Semen Ginkgo; Return the taste warp, have the monarch and his subjects' of drawing medicine to go into the effect of taste warp, be messenger drug.Can go into the warp of the five internal organs entirely, play tonification the five internal organs healthy energy altogether, mend and do not grow greasyly, loose and do not hinder just effect.The scalable body's immunity, slow down aging, looks improving and the skin nourishing also has the antineoplastic effect.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition that can improve immunity, this pharmaceutical composition is low to body's immunity, sub-health population has the effect that improves immunity; Be specially adapted to improve prolonged illness, postoperative body void, tumor patient, put, patient's immunity after the chemotherapy, this pharmaceutical composition has strengthening body, slow down aging to healthy population simultaneously, the health-care effect of looks improving and the skin nourishing.
The present invention also aims to provide the application of this pharmaceutical composition.
The present invention is achieved by the following technical solutions:
Pharmaceutical composition of the present invention is by comprising that following materials of weight proportions makes:
Fructus Momordicae 10-30 part, Semen Ginkgo 1-15 part, Fructus Lycii 2-15 part, Ganoderma 1-15 part, Rhizoma Zingiberis Recens 3-20 part.
The preferred following weight proportion of pharmaceutical composition of the present invention:
Fructus Momordicae 14-20 part, Semen Ginkgo 3-10 part, Fructus Lycii 4-10 part, Ganoderma 3-9 part, Rhizoma Zingiberis Recens 6-12 part.
The more preferably following weight proportion of pharmaceutical composition of the present invention:
15 parts of Fructus Momordicaes, 3 parts of Semen Ginkgoes, 4 parts of Fructus Lycii, 4 parts of Ganodermas, 8 parts in Rhizoma Zingiberis Recens.Pharmaceutical composition of the present invention can be made various common formulations, as tablet, granule, powder, oral liquid, capsule, pill or the like, and preferred particulates agent, capsule and oral liquid.
The preparation method and the technology of several concrete preparations are provided below:
The invention provides the preparation method of aforementioned pharmaceutical compositions granule, this method may further comprise the steps: Ganoderma, Semen Ginkgo are used ethanol extraction, extracting solution is concentrated, and drying, and be crushed and screened into medicated powder; With Fructus Momordicae, Fructus Lycii, Rhizoma Zingiberis Recens water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With twice medicated powder mix homogeneously, make granule with conventional method.
Perhaps, Ganoderma is used ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; Semen Ginkgo is used ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder, and with Fructus Momordicae, Fructus Lycii, Rhizoma Zingiberis Recens water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With three medicated powder mix homogeneously, make granule with conventional method.
With granule drying, the granulate of above-mentioned gained, can obtain capsule after the fill in the capsule shells.
The present invention also provides the preparation method of this drug composition oral liquid, and this method comprises: Ganoderma, Semen Ginkgo are used ethanol extraction, extracting solution is concentrated, and drying, and be crushed and screened into medicated powder; With Fructus Momordicae, Fructus Lycii, Rhizoma Zingiberis Recens water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; After directly or as required adding correctives and/or antiseptic behind twice medicated powder mix homogeneously, the reuse conventional method is made oral liquid.
Perhaps, Ganoderma is used ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; Semen Ginkgo is used ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder, and with Fructus Momordicae, Fructus Lycii, Rhizoma Zingiberis Recens water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; After directly or as required adding correctives and/or antiseptic behind three medicated powder mix homogeneously, the reuse conventional method is made oral liquid.
The specific embodiment
Embodiment 1
With Ganoderma 10g, Semen Ginkgo 10g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With Fructus Momordicae 100g, Fructus Lycii 20g, Rhizoma Zingiberis Recens 30g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With twice medicated powder mix homogeneously, make granule with conventional method.
Embodiment 2
With Ganoderma 15g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With Semen Ginkgo 15g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder, and with Fructus Momordicae 30g, Fructus Lycii 15g, Rhizoma Zingiberis Recens 20g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With three medicated powder mix homogeneously, make granule with conventional method.
Embodiment 3
With Ganoderma 3g, Semen Ginkgo 3g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With Fructus Momordicae 14g, Fructus Lycii 4g, Rhizoma Zingiberis Recens 6g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With twice medicated powder mix homogeneously, make granule with conventional method.
Embodiment 4
Fructus Momordicae 14-20 part, Semen Ginkgo 3-10 part, Fructus Lycii 4-10 part, Ganoderma 3-9 part, Rhizoma Zingiberis Recens 6-12 part.With Ganoderma 9g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With Semen Ginkgo 10g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder, and with Fructus Momordicae 20g, Fructus Lycii 10g, Rhizoma Zingiberis Recens 12g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With three medicated powder mix homogeneously, make granule with conventional method.
Embodiment 5
With Ganoderma 10g, Semen Ginkgo 10g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With Fructus Momordicae 100g, Fructus Lycii 20g, Rhizoma Zingiberis Recens 30g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; After directly or as required adding correctives and/or antiseptic behind twice medicated powder mix homogeneously, the reuse conventional method is made oral liquid.
Embodiment 6
With Ganoderma 9g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With Semen Ginkgo 10g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder, and with Fructus Momordicae 20g, Fructus Lycii 10g, Rhizoma Zingiberis Recens 12g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; After directly or as required adding correctives and/or antiseptic behind three medicated powder mix homogeneously, the reuse conventional method is made oral liquid.
Embodiment 7
With Ganoderma 10g, Semen Ginkgo 10g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With Fructus Momordicae 100g, Fructus Lycii 20g, Rhizoma Zingiberis Recens 30g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; After directly or as required adding correctives and/or antiseptic behind twice medicated powder mix homogeneously, the reuse conventional method is made oral liquid.
Embodiment 8
With Ganoderma 9g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With Semen Ginkgo 10g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder, and with Fructus Momordicae 20g, Fructus Lycii 10g, Rhizoma Zingiberis Recens 12g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; After directly or as required adding correctives and/or antiseptic behind three medicated powder mix homogeneously, the reuse conventional method is made oral liquid.
Embodiment 9
With Ganoderma 40g, Semen Ginkgo 30g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With Fructus Momordicae 150g, Fructus Lycii 40g, Rhizoma Zingiberis Recens 8g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With twice medicated powder mix homogeneously, make granule with conventional method.
Embodiment 10
With Ganoderma 12g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With Semen Ginkgo 9g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder, and with Fructus Momordicae 45g, Fructus Lycii 12g, Rhizoma Zingiberis Recens 24g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With three medicated powder mix homogeneously, make granule with conventional method.
Embodiment 11
With Ganoderma 4g, Semen Ginkgo 3g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; With Fructus Momordicae 15g, Fructus Lycii 4g, Rhizoma Zingiberis Recens 8g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; After directly or as required adding correctives and/or antiseptic behind twice medicated powder mix homogeneously, the reuse conventional method is made oral liquid.
Embodiment 12
Sieve concentrates Ganoderma 8g ethanol extraction with extracting solution, drying, and be crushed and screened into medicated powder; With Semen Ginkgo 6g ethanol extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder, and with Fructus Momordicae 30g, Fructus Lycii 8g, Rhizoma Zingiberis Recens 16g water extraction, extracting solution is concentrated, drying, and be crushed and screened into medicated powder; After directly or as required adding correctives and/or antiseptic behind three medicated powder mix homogeneously, the reuse conventional method is made oral liquid.
Above embodiment only is used for describing embodiments of the present invention, but these embodiment and unrestricted embodiments of the present invention.The present invention has how many different embodiments, has more than to be limited to content described in this description.
Pharmacological testing research
1. pharmaceutical composition of the present invention suppresses B16 cell lung and shifts test
Get the SD rat, body weight 200-250g, male and female half and half, rat is by continuous 10 days of 50md/kg dosage gastric infusion every day, and after last administration 2-3 hour, the socket of the eye venous plexus was got blood system and is pastille serum from serum, through 56 ℃, 30 minutes, after the deactivation freezing preservation standby, be contrast with normal rat serum.The strain of murine melanoma B16 tumor, RPMI1640 adds the cultivation of going down to posterity of 10% hyclone culture fluid.Be that the tumor cell of 24 hours In vitro culture of pastille serum In vitro culture B16 cytosis of 5%, 10%, 20% and 30% is collected with trypsinization with final concentration respectively, HBSS washes 3 times, makes 1 * 10
5/ ml cell suspension, in the tail vein injected C57BL/6 mice body, every group of 6 animals were got Mus lung branch on count tuberosity after 3 weeks, the results are shown in Table 1 with 0.12ml.
The influence that table 1 medicine shifts murine melanoma B16 cell lung
It is inhibited that result of the test shows that pastille serum shifts the lung tuberosity of B16 cell, and variable concentrations pastille serum treatments B 1624 hours is dose dependent to the lung metastasis inhibition.
2. pharmaceutical composition of the present invention is to the BALB/c mouse Immune Effects
24 BALB/c mouse are divided into 3 groups at random, and 8 every group, matched group gavages distilled water, continuous 7 days every day; Pharmaceutical composition of the present invention gavages its solution every day, and continuous 7 days, dosage was 40g/kg; Positive controls is selected ZHENQI FUZHENG JIAONANG for use, gavages its solution every day, and dosage is 40g/kg; Last administration 24 as a child, each is organized mice and carries out the eye socket sacrificed by exsanguination and get peripheral blood, puts into anticoagulant tube, aseptic spleen and the peritoneal exudate cells got, make the active detection of erythrocyte C3b receptor, splenocyte increment reaction and peritoneal macrophage C3b receptor activity respectively and detect, the results are shown in Table 2.
Detect 2.1 the erythrocyte C3b receptor is active
Erythrocyte is made into 1.25 * 10
7/ ml uses liquid, and complement sensitization zymosan is made into 1 * 10
8/ ml uses liquid, and two kinds are used liquid to mix by 1: 1, put 37 degree water-baths 30 minutes, with the fixing smear of 0.25% glutaraldehyde, dyes, and microscopy is counted in 200 erythrocyte the rosette rate in conjunction with 3 above zymosans.
2.2 splenocyte increment reaction
Spleen is ground, remove by filter erythrocyte, be made into 5 * 10 with RPMI-1640
8/ ml splenocyte suspension, 40 hole plastic culture plates are cultivated, and after every hole adds ConA, cultivate 72 hours in the carbon dioxide incubator, measure the increment reaction result with the MTT colorimetric analysis then.
2.3 peritoneal macrophage C3b receptor activity
Aseptic absorption mouse peritoneal emigrated cell, drip on slide, under 37 degree conditions, placed 2 hours, wash away not attached cell, drip an amount of sensitization yeast, 4 degree 1 as a child washed away unconjugated yeast down, the fixing dyeing of 0.25% glutaraldehyde, microscopy calculates in 200 abdominal cavity attached cells the rosette rate in conjunction with 2 above zymosans.
Table 2 medicine is to the BALB/c mouse Immune Effects
* compare P＜0.05 with the normal group analog value.
This experiment with ZHENQI FUZHENG JIAONANG as positive drug, effect to pharmaceutical composition raise immunity of the present invention is studied, the result proves that pharmaceutical composition of the present invention has the function of tangible enhancing human body immunity power, experimental result shows that pharmaceutical composition of the present invention can significantly improve Turnover of Mouse Peritoneal Macrophages C3b receptor activity and phagocytosis of macrophages, and this can make body that the phagocytosis of the tumor cell of sudden change formation is strengthened.
3. pharmaceutical composition of the present invention is to accepting lethal dose cytosine arabinoside (ARA-C) mice existence test
30 Kunming mouses are divided into 3 groups at random, and matched group gavages distilled water, continuous 7 days every day; Pharmaceutical composition of the present invention gavages its solution every day, and continuous 7 days, dosage was 40g/kg; Positive controls is selected ZHENQI FUZHENG JIAONANG for use, gavages its solution every day, and dosage is 40g/kg; 4 groups all respectively at the 0th, 8,24 hour lumbar injection ARA-C, and every Mus injection 12ml is at preceding 2 hours oral corresponding dosage pharmaceutical composition extracting solution of the present invention of injection ARA-C, after every other day once, totally 5 times, observed for 2 weeks, write down each treated animal existence situation, the results are shown in Table 3.
Table 3 medicine is to accepting the influence of lethal dose ARA-C mice existence
* compare P＜0.05 with the normal group analog value.
But result of the test shows pharmaceutical composition significant prolongation of the present invention and gives the life of cytosine arabinoside with the lethal dose mice, this invention pharmaceutical composition can significantly improve because chemotherapy makes the ubiquitous cell of body and humoral immunoresponse(HI) and the significantly reduced situation of immunoregulation effect, thereby keeps the interior environment of body relatively stable.This experimental result shows that this invention pharmaceutical composition is to had the restitution of significant protective effect and pair cell immunologic hypofunction by the caused immunity degradation of chemotherapy, for clinical raising is put, chemotherapy patients's immunologic function provides foundation.
Above pharmacological evaluation only is used for describing the effect that pharmaceutical composition of the present invention can improve immunity, but this pharmacological evaluation and unrestricted pharmaceutical composition of the present invention have the effect that other aspects improve immunity.Pharmaceutical composition of the present invention has many-sided effect that improves immunity, has more than to be limited to content described in this description.
Claims (8)
1. pharmaceutical composition that improves immunity is characterized in that this pharmaceutical composition made by following materials of weight proportions: Fructus Momordicae 10-30 part, Semen Ginkgo 1-15 part, Fructus Lycii 2-15 part, Ganoderma 1-15 part, Rhizoma Zingiberis Recens 3-20 part.
2. a kind of pharmaceutical composition that improves immunity as claimed in claim 1 is characterized in that this pharmaceutical composition raw material weight proportioning consists of: Fructus Momordicae 14-20 part, Semen Ginkgo 3-10 part, Fructus Lycii 4-10 part, Ganoderma 3-9 part, Rhizoma Zingiberis Recens 6-12 part.
3. a kind of pharmaceutical composition that improves immunity as claimed in claim 1 is characterized in that this pharmaceutical composition raw material weight proportioning consists of: 15 parts of Fructus Momordicaes, 3 parts of Semen Ginkgoes, 4 parts of Fructus Lycii, 4 parts of Ganodermas, 8 parts in Rhizoma Zingiberis Recens.
4. a kind of pharmaceutical composition that improves immunity as claimed in claim 1 is characterized in that said composition is used to improve the immunity of prolonged illness, postoperative body void.
5. a kind of pharmaceutical composition that improves immunity as claimed in claim 1 is characterized in that said composition is low to immunity of organisms, sub-health population has the effect that improves immunity.
6. a kind of pharmaceutical composition that improves immunity according to claim 1 is characterized in that said composition is used to improve the immunity of tumor patient.
7. a kind of pharmaceutical composition that improves immunity according to claim 1, it is characterized in that said composition be used to improve put, patient's immunity after the chemotherapy.
8. a kind of pharmaceutical composition that improves immunity according to claim 1, it is characterized in that said composition have to healthy population strengthening body, slow down aging, looks improving and the skin nourishing health-care effect.
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