CN109316517A - A kind of preparation method and application of fresh ginseng cream - Google Patents
A kind of preparation method and application of fresh ginseng cream Download PDFInfo
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- CN109316517A CN109316517A CN201811133998.7A CN201811133998A CN109316517A CN 109316517 A CN109316517 A CN 109316517A CN 201811133998 A CN201811133998 A CN 201811133998A CN 109316517 A CN109316517 A CN 109316517A
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- ginseng
- fresh ginseng
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- cream
- jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The present invention relates to a kind of preparation method and applications of fresh ginseng cream, the present invention is formed using the fresh ginseng of integration of drinking and medicinal herbs and jujube as raw material, it is mixed in proportion using fresh ginseng different parts processing method with jujube, while extracting to greatest extent and retaining natural primary saponin(e, and generate ginseng sapoglycoside Rg 3, Rk1, Rg5, the rare saponin(e component group such as Rh2, increase the small-molecule substances such as AFG using enzymatic reaction, the preparation process not destructive enzyme and protein active, the pharmacological activity of fresh ginseng cream can effectively be enhanced, give full play to the drug effect and fragrance of fresh ginseng and jujube, ginseng can be obtained to give off a strong fragrance, the fresh ginseng cream of excellent taste.Present invention can apply in terms of health food or food processing, with enhancing immune function, improve memory, anti-aging, the effects of relieving fatigue, cause blood or nervous system reduction functional disturbance etc. because of aging suitable for sub-health population and person in middle and old age, is to eat to support, to eat the health good merchantable brand for being treatment.
Description
Technical field
The invention belongs to health product technology fields, and in particular to a kind of preparation method and application of fresh ginseng cream.
Background technique
Ginseng (Panax ginsengC. A. Mey) it is the great traditional characteristics Chinese herbal medicine in China, it is known as " hundred grass
King " records in Shennong's Herbal, and ginseng " nontoxic, long term usage is not harmful to the health, the not old macrobiosis of the QI invigorating that can make light of one's life by commiting suicide " is classified as top grade.Have
It reinforcing vital energy, production of sperm is calmed the nerves, the effects of eyesight-improving intelligence-developing, experimental researches prove that, ginseng is to nervous system, endocrine system and blood
The logical aspect of liquid stream, good Biphasic Regulation, and can build up health, improve immune function, all multiactions such as intelligence development are lived
Property ingredient includes ginsenoside, panaxan, a variety of amino acid, volatile oil etc., and wherein ginsenoside (ginsenoside) is most
For important active constituent, and through processing after, ginsenoside converts, and pharmacological activity is remarkably reinforced, (referring to Jin
ZH, et al. Enhancement of oral bioavailability and immune response of
Ginsenoside Rh2 by co-administration with piperine. Chin J Nat Med 2018; He
LX, et al. Ginseng (Panax ginseng Meyer)oligopeptides regulate innate and
adaptive immune responses in mice via increased macrophage phagocytosis
Capacity, NK cell activity and Th cells secretion. Food Funct 2017.).Wherein ginseng
Rare saponin(e Rg3 and Rh2 has good medical value, such as 20 (R)-Rg3 of anti-cancer drugs " Shenyi capsule ", studies table at present
Bright, the rare saponin(e such as ginseng sapoglycoside Rg 3 and Rh2 not only has anticancer, anti-tumor activity, it may have enhancing immunity of organisms resists
The effects of aging, intelligence development, is alleviated in oxidation, (referring to: Choi Y J, et al. Stimulation of DDX3
expression by ginsenoside Rg3 through the Akt/p53 pathway activates the
innate immune response via TBK1/IKKε/IRF3 signalling. CurrMedChem. 2014; Yang
J, et al. Semisynthesis and bioactive evaluation of oxidized products from 20
(S)-ginsenoside Rg3, Rh2, protopanaxadiol (PPD) and their 20(R)-epimers as
Cytotoxic agents. Steroids 2016.).
In recent years, as research deepens continuously, the remarkable efficacy of ginseng gradually obtains the approval of people, in addition modern society
It is constantly progressive, rhythm of life is accelerated, and social competition's pressure is gradually increased, and irregular eating habit makes at more and more people
In " sub-health state ", often there is phenomena such as insomnia forgetfulness, the state of mind is bad, appetite stimulator, immunity degradation, machine can be accelerated
Body aging, therefore, the development of Jinseng health-care food become more and more important with exploitation, while meeting needed by human body nutritional ingredient, can more increase
The effects of strong immune function, raising is antifatigue, alleviates aging.
Paste is one of conventional dosage forms of Chinese medicine, paste dosage form made of usually decocting concentration with water or vegetable oil,
Dosage can be determined according to the different constitutions of people and clinical manifestation, frequently with through-supplementation, method of being association of activity and inertia, it is easier to which human body is inhaled
The characteristics of receiving, having both treatment and nourishing is the preferred dosage form for being suitble to four seasons health.Often ginseng extract is made with temperature compensation drug in ginseng,
It is health food most welcomed by the people in processing of Panax ginseng product.
Such as: CN201110233537.9 has been invented a kind of by Ginseng Products (sun-dried ginseng, red ginseng, dali ginseng etc.), medicine food
The ginseng extract that homologous plant (fructus lycii, jujube, hawthorn, longan), rock sugar, edible agar form, the ginseng extract production method are
Concentrated extracting solution is obtained after being pulverized and mixed by Ginseng Products and medicinal and edible plant, and is proportionally added into rock sugar, edible agar, is added
After hot a period of time, cooling obtained ginseng extract has the function of nourishing and health preserving.
CN201510465366.0 has been invented a kind of using ginseng, jujube, honey as the preparation of the compound ginseng paste of raw material
Method, according to ginseng 1-10 mass parts, jujube 1-20 mass parts, 1-100 parts of honey.The production method is ginseng and jujube
After crushing respectively, appropriate solvent is added and extracts and filters, is concentrated into paste, proper proportion honey is added, is uniformly mixed and is made
Ginseng Compound Extract.Convenient to take with carrying, QI invigorating qi-restoratives relieves fatigue, and improves immunity.
CN201510838740.7 has invented a kind of preparation method that ginseng extract is concentrated, using ginseng and honey as raw material, benefit
Employment is participated in into pure water, and heating decocts to obtain Ginseng extract, and after honey is added, vacuum concentration is cooling up to concentration ginseng
The effects of cream has and reinforces vital energy, reinforces the spleen to benefit the lung, promoting production of body fluid and inducing sedation of the mind.
CN201611253481.2, the production method for inventing a kind of fresh ginseng cream are added after smashing fresh ginseng grinding
Auxiliary material (honey, oligomeric different wheat syrup) vacuum filling, the fresh ginseng cream made of the disinfection of brief period of vacuum cold sterilization, is able to maintain
The original pharmacological activity of fresh ginseng and mouthfeel, are stored at room temperature 24 months.
CN201810089185.6, the production method for having invented a kind of Black people's ginseng honey ointment, the method is joined using Black people
Cream, black fruit fructus lycii extracting solution, longan extracting solution, jujube extracting solution, rhizoma polygonati extracting solution, ginger extract, black fungus extracting solution, tea
Propylhomoserin solution is raw material, joins honey ointment by suitably matching resulting Black people.
By the above existing ginseng extract preparation process it is found that being primarily present following problems: (1) passing through addition food additives
With ginseng extract obtained by plant extraction liquid, to increase harmful substance intake, and effective component is diluted；(2) ginseng is not fully considered
Mailland reaction product assay is combined in the synergistic effect and heating process being also easy to produce with other drugs to the shadow of its effect
It rings；(3) during processing of Panax ginseng, the change of rare ginsenoside, and the influence to ginseng extract beneficial effect are not emphasized；
(4) using sterilizing, often by modes such as high temperature and brief period of vacuum, enzyme and protein active in ginseng is greatly destroyed, people is changed
The proper constituent and pharmacological activity of ginseng；(5) do not consider that ginseng integrally enters cream as raw material usually using ginseng main root extracting solution
Not the disadvantages of agent does not give full play to ginseng mass action, easily causes the loss of raw material.
Summary of the invention
In order to solve the above problems existing in the present technology, it the present invention provides a kind of preparation method of fresh ginseng cream and answers
With, it specifically provides a kind of ginseng and gives off a strong fragrance, the preparation method of the fresh ginseng cream of excellent taste and its in terms of health care product
Using.
The present invention can sufficiently make up the above existing ginseng extract technical disadvantages, and using fresh ginseng as primary raw material, and compatibility has
The jujube of the effects of tonifying middle-Jiao and Qi, nourishing blood and tranquilization, regulating spleen and stomach function has " natural vitamin ball " good reputation, the two phase interworking
It closes, gives full play to original effect of fresh ginseng and jujube, do not add any chemical component, meanwhile, make full use of fresh ginseng adding
During work, ginsenoside type and content be increased, and occur having the ginseng sapoglycoside Rg 3 of greater activity, Rk1,
The rare saponin(e component group such as Rg5 and Rh2, and increase the small-molecule substances such as enzymatic reaction product AFG, therefore medical value is more rich
It is rich.
The present invention is achieved through the following technical solutions:
A kind of fresh ginseng ointment preparation, it is characterised in that include the following steps: (1) selection fresh ginseng and jujube, ginseng is first
Carrying out ginseng must separate with main root, and jujube is ground into 200 mesh impalpable powders；(2) certain proportion pure water is added in ginseng fibrous root, through excessive
Fire boils, and mild fire boils 20-30min later, repeats 1-2 times, and concentration is merged after filtering must water to get ginseng；(3) will ginseng must water with
The mixing of ginseng main root is smashed the grinding of fresh ginseng main root using tissue pulverizer, and fresh ginseng tissue is crushed to diameter less than 1mm；
(4) fresh ginseng for crushing pulp tissue is mixed in proportion with jujube fine powder and is boiled in 45 ± 5 °C of decompressions, paste is made；
(5) restore after boiling and be stored in 37 ± 5 °C, it is quantitative filling while hot；(6) product vacuum sealing, constant-temperature high-pressure sterilizing；(7) it makes
Obtain finished product.
Through a large number of experiments the study found that acting not only as good Extraction solvent using ginseng palpus water, at the same it is unexpected
Discovery using ginseng must water be used as solvent, extract and retain naturally primary saponin(e while, and generate ginseng sapoglycoside Rg 3,
The rare saponin(e component group such as Rk1, Rg5, Rh2 increases small-molecule substances, the preparation processes such as AFG using enzymatic reaction and does not destroy
Enzyme and protein active can effectively enhance the pharmacological activity of fresh ginseng cream, give full play to the drug effect and fragrance of fresh ginseng and jujube.And
And the chemical component joined in palpus is utilized, and ginseng resource has utmostly been used.
A preferred embodiment of the present invention the most: 2-7 times that jujube fine powder amount is fresh ginseng quality, addition pure water is added
Amount is 10-30 times of fresh ginseng quality.
A preferred embodiment of the present invention the most:: gained ginseng must the best concentration ratio of water be ginseng main root quality 4-5
Times, 3 times that jujube fine powder amount is fresh ginseng quality are added.
A preferred embodiment of the present invention the most: decompression tanning is that control pressure is to boil 30-60 minutes under 1.1Mpa；It is permanent
Warm high pressure sterilization is that temperature is controlled at 50 ± 2 °C, pressure 120Mpa, and constant-temperature high-pressure sterilizes 60min.
Through a large number of experiments the study found that being cooperated using aforementioned Extraction technique, it can extract and protect to greatest extent
While staying natural primary saponin(e, and the rare saponin(e component group such as ginseng sapoglycoside Rg 3, Rk1, Rg5, Rh2 is generated, it is anti-using enzymatic
The small-molecule substances such as AFG should be increased, improve the medical value of ginseng extract.
Another object of the present invention is to provide a kind of new fresh ginseng cream, and the fresh ginseng cream passes through preparation method above-mentioned
It is prepared.
It is small that the ginseng extract contains 16 kinds of ginseng sapoglycoside Rg 3, Rk1, Rg5 and Rh2 etc. rare saponin(e component groups and AFG etc.
Molecular substance.
Compared with existing ginseng extract preparation process, total Ginsenosides Content can be improved 2-3 times, ginseng sapoglycoside Rg 3, Rk1,
The rare saponin content such as Rg5 and Rh2 improves 50% or more.
Another object of the present invention provides fresh ginseng cream described in one kind and is preparing enhancing immunity of organisms, improving memory, anti-
Aging, the application of the health care product relieved fatigue.
And the fresh ginseng cream is in the application for the health care product for preparing APAP induction acute liver damage.
With fresh ginseng cream the health care product for preparing injury of kidney caused by CDDP application.
Commercially available ginseng extract product is obtained relative to conventional method, raising, explanation are had obvious effects in terms of aforementioned applications
It is effectively enriched with using preceding method and has obtained more effective active constituent, be that the application of the product plays more positive work
With.
Inventive principle and beneficial effect of the invention include:
Fresh ginseng cream of the present invention is to make full use of fresh ginseng feature, using different parts processing method, is protected to greatest extent
The peculiar fragrance of fresh ginseng and natural component are stayed, is completely superior to using sun-dried ginseng and red ginseng be ginseng extract made by raw material, and
The rare saponin(e component group not contained in fresh ginseng can be generated in process, research has shown that, fresh ginseng cream of the invention is not only
The fresh peculiar fragrance of ginseng can be retained, and content of ginsenoside is apparently higher than using sun-dried ginseng and red ginseng as ginseng extract made of raw material,
More increase the generation of the small molecules such as AFG using enzymatic reaction, medical value is extremely abundant.
Fresh ginseng cream obtained by the present invention can sufficiently make up the deficiency of existing ginseng extract technical matters, to greatest extent
Retain saponin simultaneously, and generates with 16 kinds of ginseng sapoglycoside Rg 3, Rk1, Rg5 and Rh2 etc. rare saponin(e component groups, and utilize
Enzymatic reaction increases the small-molecule substances such as AFG, and with the jujube compatibility that is rich in vitamin, do not add any chemical component, sufficiently
It using the peculiar fragrance of ginseng and the two natural activity, can not only improve mouthfeel, but also the dry property of ginseng can be reduced, and use constant-temperature high-pressure
The mode of sterilizing, not destructive enzyme and protein active, constituent of ginseng and active change caused by avoiding because of high temperature meet the present age fast section
Play health of people health care requirement.
Fresh ginseng cream obtained by the present invention have it is portable, take safety, can QI invigorating qi-restoratives, raise qi and blood feature,
Can be improved by memory, anti-aging, relieve fatigue, adjust the health cares such as nervous system for lesions of liver and kidney protective effect in strengthen immunity
It is applied in terms of food or food processing, is the health good merchantable brand of inferior health and mid-aged population.
The processing method that the present invention uses different extract fractions of Radix ginseng comprehensively utilizes ginseng and big with fresh ginseng generally raw material
Jujube natural activity, had not only been effectively improved the mouthfeel of product, but also can be relieved the dry property of ginseng, and was sterilized using constant-temperature high-pressure, in maximum
While limit retains saponin, the activity of protein and enzyme is not destroyed yet, is sufficiently reserved jujube and the peculiar fragrance of fresh ginseng,
It gives off a strong fragrance to be formed, the fresh ginseng cream of excellent taste is really achieved the effect of " qi-blood tonifying ", can be effectively improved inferior health
Crowd and because aging causes the symptoms such as functional disturbance.
Detailed description of the invention
The HPLC of Fig. 1, the present invention and prior art analyzes comparison schematic diagram；
Fig. 2, nephridial tissue H&E pathological section figure observation schematic.
Specific embodiment
The present invention can be further illustrated by the following examples.
Embodiment 1:
20 mass parts of fresh ginseng, 60 mass parts of jujube are selected, first by ginseng net system, carrying out ginseng must separate with main root, while will be big
Date powder is broken into 200 mesh impalpable powders, then ginseng fibrous root is added to the pure water of 1:30 ratio in quality, and by being boiled by fire, mild fire is endured
Ginseng palpus water after being repeated twice, is concentrated into 4 times of ginseng main root quality, after being cooled to room temperature, ginseng palpus water is poured by 30min processed
Smashed in tissue pulverizer equipped with ginseng main root, ginseng main root tissue is crushed to diameter less than 1mm, be ground into after homogenate shape with
Jujube impalpable powder mixes, and is that 1.1Mpa is boiled 30 minutes in 45 °C of control pressure, is brewed into paste, filling, is pumped into after filling
Vacuum, the 60min that sterilizes under 50 ± 2 °C of constant-temperature high-pressure states is to get fresh ginseng cream.
Embodiment 2:
20 mass parts of fresh ginseng, 80 mass parts of jujube are selected, first by ginseng net system, carrying out ginseng must separate with main root, while will be big
Date powder is broken into 200 mesh impalpable powders, then ginseng fibrous root is added to the pure water of 1:30 ratio in quality, and by being boiled by fire, mild fire is endured
Ginseng palpus water after being repeated twice, is concentrated into 4 times of ginseng main root quality, after being cooled to room temperature, ginseng palpus water is poured by 30min processed
Smashed in tissue pulverizer equipped with ginseng main root, ginseng main root tissue is crushed to diameter less than 1mm, be ground into after homogenate shape with
Jujube impalpable powder mixes, and is that 1.1Mpa is boiled 30 minutes in 45 °C of control pressure, is brewed into paste, filling, is pumped into after filling
Vacuum, the 60min that sterilizes under 50 ± 2 °C of constant-temperature high-pressure states is to get fresh ginseng cream.
Embodiment 3:
20 mass parts of fresh ginseng, 100 mass parts of jujube are selected, first by ginseng net system, carrying out ginseng must separate with main root, while will be big
Date powder is broken into 200 mesh impalpable powders, then ginseng fibrous root is added to the pure water of 1:30 ratio in quality, and by being boiled by fire, mild fire is endured
Ginseng palpus water after being repeated twice, is concentrated into 4 times of ginseng main root quality, after being cooled to room temperature, ginseng palpus water is poured by 30min processed
Smashed in tissue pulverizer equipped with ginseng main root, ginseng main root tissue is crushed to diameter less than 1mm, be ground into after homogenate shape with
Jujube impalpable powder mixes, and is that 1.1Mpa is boiled 30 minutes in 45 °C of control pressure, is brewed into paste, filling, is pumped into after filling
Vacuum, the 60min that sterilizes under 50 ± 2 °C of constant-temperature high-pressure states is to get fresh ginseng cream.
Embodiment 4:
20 mass parts of fresh ginseng, 100 mass parts of jujube are selected, first by ginseng net system, carrying out ginseng must separate with main root, while will be big
Date powder is broken into 200 mesh impalpable powders, then ginseng fibrous root is added to the pure water of 1:30 ratio in quality, and by being boiled by fire, mild fire is endured
30min processed after being repeated twice, in 45 °C of tanning 2h at paste, is evacuated, in 120 ± 2 °C of high temperature pressure constant states after filling
Lower sterilizing 60min is to get fresh ginseng cream.
Embodiment 5:
High-quality 20 mass parts of sun-dried ginseng, 100 mass parts of jujube are selected, sun-dried ginseng and jujube are respectively crushed into 200 mesh impalpable powders,
The pure water of 1:30 ratio is added in sun-dried ginseng quality again, jujube is uniformly mixed with sun-dried ginseng powder, is in 45 °C of control pressure
1.1Mpa is boiled 30 minutes, is brewed into paste, filling, is evacuated after filling, is sterilized under 50 ± 2 °C of constant-temperature high-pressure states
60min is to get ginseng extract.
Embodiment 6:
High-quality 20 mass parts of sugar-free red ginseng, 100 mass parts of jujube are selected, red ginseng and jujube are respectively crushed into 200 mesh impalpable powders,
The pure water of 1:30 ratio is added in red ginseng quality again, jujube is uniformly mixed with red ginseng powder, is in 45 °C of control pressure
1.1Mpa is boiled 30 minutes, is brewed into paste, filling, is evacuated after filling, is sterilized under 50 ± 2 °C of constant-temperature high-pressure states
60min is to get ginseng extract.
Embodiment 7:
The ginseng extract as made from the above different material and method, using UV, rare soap in HPLC/MS assay ginseng extract
Glycosides component, general ginsenoside and small-molecule substance AFG etc., HPLC is more as shown in Fig. 1；Comparision contents are as shown in table 1.It is (small
Molecular substance is by taking AFG content as an example, and rare saponin(e is by taking Rg3 content as an example, unit: mg/g)
1: three kind of fresh ginseng cream small molecular substance of table, rare saponin(e and total saponin content compare
By ginsenoside to above six kinds of ginseng extracts and small molecule comparison of ingredients it is found that 1-3 of the embodiment of the present invention took
The different processing methods of ginseng palpus, can increase substantially ginsenoside and small molecule object in ginseng extract relative to 4 conventional method of embodiment
Matter content, and comparative example 5,6 illustrates that fresh ginseng is easier to saponin(e and other active components using sun-dried ginseng and red ginseng as raw material
It is precipitated, and the rare saponin(e component such as generate Rg3, Rk1, Rg5 and Rh2, while increasing the generation of the small-molecule substances such as AFG, well
Enhance the peculiar fragrance and mouthfeel of fresh ginseng cream.Simultaneously compared with high-temperature sterilization method, constant-temperature high-pressure sterilizing can be protected to greatest extent
Effective component dissolution in fresh ginseng is demonstrate,proved, enzyme and protein active in fresh ginseng cream are avoided damage to, utmostly retains fresh ginseng and big
The natural activity of jujube；In addition, by high-temperature sterilization mode have it is denseer be charred sense, destroy the peculiar fragrance of fresh ginseng, mouthfeel
It is very poor.
Embodiment 8: fresh ginseng cream has apparent relaxation effect to the fatigue of sub-health population
As society is constantly progressive, rhythm of life and stress increase, and are also easy to produce a series of phenomenons such as fatigue, are " inferior healths
State " crowd's common problem, is the one of the major reasons of body movement ability and function point analysis decline, this experiment passes through
Lactic acid concn, urea nitrogen concentration and hepatic glycogen content are as evaluation body fatigue resistance in the swimming time and Mice Body of mouse
Index.This experiment is using the preparation method of optimum proportioning in above-described embodiment as foundation, respectively by embodiment 5,6 methods with sun-dried
Ginseng, the ginseng extract that red ginseng is raw material and fresh ginseng cream of the invention investigate ginseng extract to the antifatigue of mouse as test medicine
Effect to be developed there is the fatigue effect health food for alleviating sub-health state crowd to provide scientific basis.
Male ICR mouse after adaptable fed 1 week is randomly divided into 5 groups, i.e. blank control group, model group, sun-dried ginseng is former
Expect ginseng extract (experimental group 1, commercially available), red ginseng raw material ginseng extract (experimental group 2, commercially available), 1 fresh ginseng cream of the embodiment of the present invention is (real
Test group 3).2 batches of experiments are set altogether, and test medicine, dosage 150mgkg are administered using stomach-filling mode-1, continuous gavage 14
It, animal freely ingests and diet.
Weight measurement: since experiment, the constitution of each group mouse is measured at the end of experiment in the 7th day and the 14th day respectively
Amount, the results are shown in Table 2:
As shown in Table 2, the no matter initial weight of mouse, mid-term weight or final weight, difference is without significant between each group
Property (P> 0.05), illustrate the present invention on mouse weight without influence
Swimming with a load attached to the body experiment: after first last dose given the test agent 30min, the weight bearing of mouse tail root, loading weight is weight
5%.Mouse be put in depth of water 30cm, water temperature (25 ± 0.5) °C swimming trunk in, record is all sunk to head from swim
Cannot emerge in water (death) time (s) as its walking weight load.
Blood lactase acid, serum urea nitrogen and hepatic glycogen measurement: after the 2nd batch of last gives given the test agent 30min, mouse socket of the eye vein
20 μ l of blood is taken to survey preceding lactic acid concn of swimming.Then mouse is put in the swimming trunk went swimming 90min that water temperature is 30 °C, depth of water 35cm
After stop, plucking eyeball blood sampling immediately, take blood lactase acid after 20 μ l measurement swimming horizontal, remaining blood sample places 4 °C of refrigerators 3h, 3500r/
Min is centrifuged 10min；After separating serum, measurement serum urea nitrogen is analyzed with full-automatic biochemical.Animal is put to death immediately after taking blood, is taken
Liver is blotted after physiological saline rinses with filter paper, accurately weighs liver 100mg, measures glycogen raw water with kit (anthrone method)
It is flat.Measurement result is as shown in table 3:
Compared according to 3 swimming time of table it is found that the ginseng extract of different material can extend mice burden swimming to varying degrees
Time, of the present invention group is then substantially better than experimental group 1 and 2, meanwhile, pass through blood lactate concentration, serum after measurement mouse weight loading exercise
Hepatic glycogen content in urea nitrogen and liver is it is found that compared with the control group, blood lactase acid level and urea nitrogen content obviously increase, administration
Group can then inhibit the increase of its content in various degree, and of the present invention group of effect is the most obvious；From the point of view of hepatic glycogen content, of the present invention group
Can maintain hepatic glycogen content well, and closer to blank control group (P< 0.001), illustrate that fresh ginseng cream of the invention has
Apparent antifatigue effect.
Embodiment 7: protective effect of the fresh ginseng cream to cis-platinum (CDDP) induction injury of kidney
By above-mentioned experiment, absolutely prove that fresh ginseng cream has good relaxation effect to the fatigue phenomenon of sub-health population, hence it is evident that
Better than using sun-dried ginseng and red ginseng as the ginseng extract of raw material, enhance body's immunity to further illustrate that fresh ginseng has, it is right
APAP induces acute liver damage and the injury of kidney of CDDP induction has obvious protective function, this experiment is with CDDP induction injury of kidney
For protective effect, by measurement mice serum in blood urea nitrogen (BUN) and creatinine (CRE) level, tissue oxidizing stress journey
Degree, and combine Pathological slice (H&E) be reference frame, illustrate fresh ginseng cream can by the protection to lesions of liver and kidney, thus
Immune function is strengthened conscientiously, the medical value of fresh ginseng cream is expanded.
Male ICR mouse after adaptable fed 1 week is randomly divided into 4 groups, i.e. blank control group, model group, fresh ginseng cream
(FGP, embodiment 1) low dose group (400mgkg-1), high dose group (800mgkg-1).Administration group uses gastric infusion, even
Continuous 10 days, blank control group and model group gave isometric physiological saline, after the 7th day 1 h of administration, in addition to blank group, remaining
Each group disposable celiac injects cis-platinum (CDDP) 20mgkg-1, FGP low dose group and high dose group dissect after continuing administration 3 days,
All mouse are run out of grain in modeling and dissection previous evening does not cut off the water supply.Mouse is lethal by cervical dislocation, carries out eyeball veniplex and takes
Blood is collected by blood, obtains serum with refrigerated centrifuge separation (3500r/min, 4 °C, 10min, 2 times), be stored in-
20 °C, it is horizontal that blood urea nitrogen (BUN) and creatinine (CRE) in serum are surveyed with urease method and enzymic creatinine assay method kit respectively；
And its internal organs of fast anatomical include: liver, spleen and kidney after being put to death, and gauge index.Wherein left kidney is placed in -80 °C of preservations, uses
It is detected in biochemical indicator；Right kidney is fixed in 10% formaldehyde for histopathological analysis.
From table 4, it can be seen that groups of animals weight increased, but FGP administration group and blank control after administration 10 days
Group compared to weight without significant difference (P> 0.05), show that the low high dose of FGP does not influence mouse weight.Research shows that: it is primary
Property intraperitoneal injection 20mgkg-1CDDP after, compared to the blank group, the changes of weight of CDDP group mouse is unobvious, and kidney refers to
Number dramatically increase (P< 0.05), FGP administration group (400mgkg-1And 800mgkg-1) then significantly reduced compared with CDDP group
(P< 0.05).In addition, the liver index between each group does not have significant change (such as table 4).
As shown in table 5, mouse is through once abdominal cavity injection CDDP(20 mgkg-1) after, CDDP group and Normal group phase
It is more horizontal than, BUN in mice serum and CRE it is significant increase (P< 0.01), show the success of cis-platinum renal injury model；With model group ratio
Compared with two dosage groups of FGP (400 and 800 mgkg-1, embodiment 1) and BUN and CRE level in serum can be significantly reduced, and have
Have conspicuousness (P< 0.01).Illustrate inhibition CDDP injury of kidney mouse BUN and the CRE water that the low high dose group of FGP can be different degrees of
Flat raising.
As shown in table 6, compared to the blank group, CDDP induces nephridial tissue MDA horizontal significantly raised, and GSH exhausts and SOD activity
Reduce (P< 0.01).On the contrary, FGP pre-processes (400 and 800 mgkg-1) can significantly be reversed after 10 days these variations (P<
0.01), and as the increase of FGP dosage is in certain dose relationship.Show that FGP may be by adjusting the oxygen such as MDA, GSH and SOD
Change stress level, to reach renal protection.
Renal pathology is observed as shown, in normal mouse nephridial tissue, and glomerulus and its surrounding renal tubule structure are just
Often and clear, extracellular matrix is evenly distributed, it is disease-free cash as；And CDDP group mesonephric glomerulus swelling, volume significantly increase, blister cavities
It obscures, tubular ectasia, renal cells partial necrosis, hyalina, karyopyknosis or disappearance, kidney occurs in lumen
Interstitial edema, interstitial inflammatory cell infiltration；FGP low dose group (400 mgkg-1) compared with CDDP group, renal tubular epithelial is thin
Born of the same parents' degree of necrosis mitigates, and karyopyknosis and extinction tests are reduced, FGP high dose group (800 mgkg-1) Bowman's capsule is intracavitary
Clear in structure, renal cells necrosis significantly reduces, and hyalina phenomenon is reduced, interstitial oedema and neutrophil leucocyte leaching
Profit is reduced, and cellular morphology returns to normal.As 2. nephridial tissue H&E pathological section figure of attached drawing is observed.
In summary experimental data shows that the ginseng extract made of content detection to fresh ginseng cream and different material is anti-
Fatigue experiment it is found that fresh ginseng cream of the present invention preparation method, ginsenoside can be retained to greatest extent, and increase AFG etc. small point
The generation of sub- substance has good antifatigue effect, hence it is evident that is better than sun-dried ginseng, red ginseng, and the injury of kidney for passing through cisplatin induction
Pharmacological evaluation further illustrate that fresh ginseng cream can play guarantor to injury of kidney by adjusting the modes such as vivo oxidation stress level
Shield sufficiently shows that fresh ginseng cream has the function of enhancing body's immunity.The present invention can retain the peculiar fragrance of ginseng, and with it is big
The mutual compatibility of jujube, can form and give off a strong fragrance, the fresh ginseng cream of excellent taste, be suitable for sub-health population and person in middle and old age due to aging
Caused functional disturbance has apparent relaxation effect, provides material reference for the application and exploitation of ginseng health product, and further
Expand the application approach of dietotherapeutic medicinal material, the deep development for ginseng and Related product provides theoretical foundation.
Claims (10)
1. a kind of fresh ginseng ointment preparation, it is characterised in that include the following steps: that (1) selection fresh ginseng and jujube, ginseng are first
First carrying out ginseng must separate with main root, and jujube is ground into 200 mesh impalpable powders；(2) certain proportion pure water is added in ginseng fibrous root, passed through
It is boiled by fire, mild fire boils 20-30 min later, repeats 1-2 times, and concentration is merged after filtering must water to get ginseng；(3) palpus will be joined
Water is mixed with ginseng main root, is smashed the grinding of fresh ginseng main root using tissue pulverizer, fresh ginseng tissue is crushed to diameter and is less than
1.0 mm；(4) fresh ginseng for crushing pulp tissue is mixed in proportion with jujube fine powder and is boiled in 45 ± 5 °C of decompressions, is made
Paste；(5) restore after boiling and be stored in 37 ± 5 °C, it is quantitative filling while hot；(6) product vacuum sealing, constant-temperature high-pressure go out
Bacterium；(7) finished product.
2. preparation method according to claim 1, it is characterised in that: 2 ~ 7 times that jujube fine powder amount is fresh ginseng quality are added,
10 ~ 30 times that amount of purified water is fresh ginseng quality are added.
3. preparation method according to claim 1, it is characterised in that: the gained ginseng palpus best concentration ratio of water is ginseng main root matter
3 times that jujube fine powder amount is fresh ginseng quality are added in 4 ~ 5 times of amount.
4. preparation method according to claim 1, it is characterised in that: decompression tanning is that control pressure is to boil under 1.1Mpa
30-60 min；Constant-temperature high-pressure sterilizing is temperature control at 50 ± 2 °C, pressure 120Mpa, and constant-temperature high-pressure sterilizes 60 min.
5. a kind of fresh ginseng cream, it is characterised in that: the fresh ginseng cream passes through the described in any item preparation method systems of embodiment 1-4
It is standby to obtain.
6. a kind of fresh ginseng cream as described in claim 5, it is characterised in that: contain ginseng sapoglycoside Rg 3, Rk1, Rg5 and Rh2 etc.
The small-molecule substances such as 16 kinds of rare saponin(e component groups and the double pool glycosides AFG of arginine.
7. fresh ginseng cream as described in claim 5, it is characterised in that: compared with existing ginseng extract preparation process, ginseng is total
Saponin content can be improved 2 ~ 3 times, and the rare saponin content such as ginseng sapoglycoside Rg 3, Rk1, Rg5 and Rh2 improves 50% or more.
8. fresh ginseng cream as described in claim 5 is preparing enhancing immunity of organisms, improvement memory, anti-aging, is relieving fatigue
Health care product application.
9. fresh ginseng cream as described in claim 5 is in the health care for preparing Acetaminophen tablets (APAP) induction acute liver damage
The application of product.
10. fresh ginseng cream as described in claim 5 is in the application for the health care product for preparing injury of kidney caused by cis-platinum (CDDP).
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| CN109619590A (en) * | 2019-03-01 | 2019-04-16 | 长沙每日滋养健康科技有限公司 | A kind of manufacturing method of instant Korean ginseng cream |
| CN109793746A (en) * | 2019-04-02 | 2019-05-24 | 延边大学 | It is a kind of to improve the composition of renal insufficiency, black conopsea extraction and its preparation method and application |
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| CN114982877A (en) * | 2022-04-06 | 2022-09-02 | 湖南微草生物科技有限公司 | Preparation process and application of ginseng extract |
| CN114848727A (en) * | 2022-06-21 | 2022-08-05 | 吉林农业大学 | Preparation method and application of American ginseng paste with health care function |
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