CN104352542A - Sea cucumber and saussurea involucrata composition preparation and preparation method thereof - Google Patents

Sea cucumber and saussurea involucrata composition preparation and preparation method thereof Download PDF

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Publication number
CN104352542A
CN104352542A CN201410532790.8A CN201410532790A CN104352542A CN 104352542 A CN104352542 A CN 104352542A CN 201410532790 A CN201410532790 A CN 201410532790A CN 104352542 A CN104352542 A CN 104352542A
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Prior art keywords
stichopus japonicus
parts
herba saussureae
preparation
saussureae involueratae
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CN201410532790.8A
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Inventor
侯书胜
丛培月
侯书海
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WEIHAI LIYUAN MARINE BIOTECHNOLOGY Co Ltd
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WEIHAI LIYUAN MARINE BIOTECHNOLOGY Co Ltd
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Priority to CN201410532790.8A priority Critical patent/CN104352542A/en
Publication of CN104352542A publication Critical patent/CN104352542A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/616Echinodermata, e.g. starfish, sea cucumbers or sea urchins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285Aucklandia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding

Abstract

The invention relates to the technical field of health care products, in particular to sea cucumber and saussurea involucrata composition preparation with comprehensive and balanced nutrition and a preparation method of the sea cucumber and saussurea involucrata composition preparation. The sea cucumber and saussurea involucrata composition preparation is characterized by comprising components in parts by weight as follows: 5.0-90.0 parts of sea cucumbers, 5.0-90.0 parts of saussurea involucrata, 10.0-30.0 parts of a ginkgo biloba extract and 1.0-5.0 parts of sweet orange meal. The composition preparation has the advantages that the preparation can improve immunity, protect heart and cerebral vessels, improve peripheral blood circulation, reduce serum cholesterol, adjust metabolism of a human body, strengthen physical strength, relieve fatigue and the like.

Description

Composite preparation of a kind of Stichopus japonicus Herba Saussureae Involueratae and preparation method thereof
Technical field
The present invention relates to health product technology field, specifically a kind ofly provide composite preparation of the Stichopus japonicus Herba Saussureae Involueratae of general equilibrium nutrition and preparation method thereof.
Background technology
Along with the progress of society, the raising of people's living standard, health has been that people's first pursue, is pursuing on healthy road, is putting prevention first, tonic health preserving, has become the common recognition of people.International Medical research proves, the composition of human body composition is very complicated, also the nutrition of reference's picked-up is again the balance of multiple nutrient matter, the health of people just can not can obtain nutritive equilibrium and health with same material, but many kinds of substance multiple nutrients and securing good health, the present invention is exactly with the composition of multiple high-quality composition, for people provide better healthy goods.
As everyone knows, Stichopus japonicus is one of seafood " eight delicacies ", equally celebrated for their achievements with Nidus collocaliae, Carnis Haliotidis, Fin Mustetus manazo, have the good reputation such as " jinxs of all kinds of diseases and ailments ", " god of longevity ", " first of hundred benefits ", " god enriched blood ", be high protein nourishing food, Herba Saussureae Involueratae have " Western Regions are very colored ", the appellation such as " sage grass ", both first-class tonic, commodity commercially available are on the market generally Stichopus japonicus or Herba Saussureae Involueratae various goods alone at present, there is no Stichopus japonicus and Herba Saussureae Involueratae composite health product.If application number 201310192941.5 1 kinds is containing the food compositions, application number 201310665617.0 1 kinds of Stichopus japonicus maca composition and preparation method thereof of Lepidinm meyenii Walp, Saussurea involucrata culture, all contain Lepidinm meyenii Walp, and it is unrestricted to Lepidinm meyenii Walp component content, Lepidinm meyenii Walp has very large side effect, and all can not take the restricted infant of applicable crowd, women breast-feeding their children, anemia of pregnant woman, Patients With Various Thyroid Disorders, minor.
Summary of the invention
The object of the invention is to solve above-mentioned the deficiencies in the prior art, provide a kind of and improve immunity, protection cardiovascular and cerebrovascular vessel; improve peripheral blood circulation; reduce serum cholesterol, regulate body metabolism, physical strength reinforcing and the anti-composite preparation except tired Stichopus japonicus Herba Saussureae Involueratae and preparation method thereof.
The technical solution adopted for the present invention to solve the technical problems is:
The composite preparation of a kind of Stichopus japonicus Herba Saussureae Involueratae, it is characterized in that being made up of Stichopus japonicus, Herba Saussureae Involueratae, Folium Ginkgo extract and Fructus Citri sinensis powder, wherein the weight proportion of Stichopus japonicus, Herba Saussureae Involueratae, Folium Ginkgo extract and each component of Fructus Citri sinensis powder is: Stichopus japonicus 5.0 ~ 90.0 parts, Herba Saussureae Involueratae 5.0 ~ 90.0 parts, Folium Ginkgo extract 10.0 ~ 30.0 parts, 1.0 ~ 5.0 parts, Fructus Citri sinensis powder.
The composite preparation preparation method of a kind of Stichopus japonicus Herba Saussureae Involueratae, it is characterized in that the fresh Stichopus japonicus first will pulled out from sea, clean, cut off, the ginseng body wall of removing internal organs, liquid containing holothurians autoenzyme in wall of sea cucumber Stichopus japonicus gives over to for subsequent use, and by the Intestinum Stichopi japonici in Stichopus japonicus internal organs and the impurity Ex-all in sea cucumber, Intestinum Stichopi japonici and sea cucumber are applied in the lump, by wall of sea cucumber Stichopus japonicus, Intestinum Stichopi japonici and sea cucumber grind making beating after pulverizing, add in enzymatic vessel, add the 5-10 water doubly of wall of sea cucumber Stichopus japonicus weight, add liquid containing holothurians autoenzyme in wall of sea cucumber Stichopus japonicus and food flavor enzyme appropriate, mix homogeneously, open steam cock, gradually 45-65 degree is warming up to, under the condition constantly stirred, maintain constant temperature 3.5-4 hour, treat that whole liquid is clarified substantially, be warming up to 100 degree, 5-10 minute, filter after cooling, by above-mentioned gained liquid, add water adjustment concentration, concentration is at 2%-10%, spray dry tower with cleaning and carry out spraying dry, spray powder is up to the standards, plastic bag evacuation is packed, cryopreservation, for subsequent use, then, by Saussurea involucrata culture raw material, vacuum drying is carried out at 60 degree, Saussurea involucrata culture raw material is qualified through chemically examining, through YSC-701 super micron mill, the fineness of the feature of the method is high, in crushing process, maximum temperature only has 45 degree, ensure that and the quality of raw material is not damaged, dust losses is atomic, and it is pollution-free, get Folium Ginkgo extract qualified according to standard test functional component, detect the qualifieds such as heavy metal, finally, take Stichopus japonicus instant powder 45.0kg, Saussurea involucrata culture powder 50.0kg, Folium Ginkgo extract 25kg, the each raw material weighed, in three-dimensional mixer, mix homogeneously, the low alcohol of mixed raw material powder does wetting agent, method of granulating is conveniently granulated, dry, getting Fructus Citri sinensis powder 5kg is in proportion mixed in the granule made, mix homogeneously, tabletting, after the assay was approved, packaging, finally by fluorescence method, Colchicine Content in preparation is measured.
The composite preparation of a kind of Stichopus japonicus Herba Saussureae Involueratae of the present invention, is characterized in that Herba Saussureae Involueratae is prepared by Saussurea involucrata culture.
A kind of Stichopus japonicus Herba Saussureae Involueratae composite preparation of the present invention, is characterized in that making powder, granule, capsule, tablet, is preferably tablet, granule.
A kind of Stichopus japonicus Herba Saussureae Involueratae composite preparation tablet of the present invention, is characterized in that tablet is prepared into confection tabletting, chewable tablet, effervescent tablet.
A kind of Stichopus japonicus Herba Saussureae Involueratae composite preparation capsule of the present invention, is characterized in that capsule is prepared into hard capsule preparation and soft capsule preparation.
A kind of Stichopus japonicus Herba Saussureae Involueratae composite preparation soft capsule preparation of the present invention, it is characterized in that soft capsule preparation adds salad oil by the mixture of Stichopus japonicus instant powder, Saussurea involucrata culture powder and Folium Ginkgo extract to grind evenly, mixture and salad oil ratio are 1:3.
Component analysis of the present invention
Stichopus japonicus: have another name called Radix Morinae Bulleyanae, extra large Mus, sea gherkin; sweet-salty; containing various nutrient elements; wherein, mucopolysaccharide has the antitumor action of wide spectrum, anticancer be grown on transfer; to the growth of malignant tumor, transfer, there is remarkable inhibitory action; holothurin has antiinflammatory, ossification, and have significant therapeutic effect to hepatitis, tuberculosis, diabetes, cardiovascular disease, medicinal health value is high.
Herba Saussureae Involueratae: nature and flavor hardship, micro-hardship, temperature; Containing multiple biological activity effective ingredient, wherein umbelliferone have significantly antibacterial, blood pressure lowering is calm, spasmolysis, scopoletin has and dispels the wind, antiinflammatory, pain relieving, to eliminate the phlegm and antitumor action, the growth of colchicine energy anticancer; Herba Saussureae Involueratae has heat-clearing and toxic substances removing, wind-damp dispelling, detumescence, analgesic efficacy, to slow down aging, allaying tiredness, neurasthenia, reduction cholesterol, adjusts blood pressure, has remarkable efficacy.
Folium Ginkgo extract (Ginkgo Biloba Extract, GBE): fragrance, bitter in the mouth, take Folium Ginkgo as raw material, one series products of the effective ingredient enrichment of extraction, there is significant antagonism paf receptor, antiinflammatory, antiallergic, blood vessel dilating effectiveness, be used for the treatment of memory loss, stomach pain, dysentery, hypertension, psychentonia and respiratory problems as asthma, bronchitis and poor circulation and the anxiety caused thereof.
The present invention, owing to adopting above-mentioned composition preparation, has raising immunity, protects cardiovascular and cerebrovascular vessel, improves peripheral blood circulation, reduces serum cholesterol, regulates body metabolism, and physical strength reinforcing removes the advantages such as tired with anti-.
Detailed description of the invention
The present invention is further described below:
The composite preparation of a kind of Stichopus japonicus Herba Saussureae Involueratae, be made up of Stichopus japonicus, Herba Saussureae Involueratae, Folium Ginkgo extract and Fructus Citri sinensis powder, wherein the weight proportion of Stichopus japonicus, Herba Saussureae Involueratae, Folium Ginkgo extract and each component of Fructus Citri sinensis powder is: Stichopus japonicus 5.0 ~ 90.0 parts, Herba Saussureae Involueratae 5.0 ~ 90.0 parts, Folium Ginkgo extract 10.0 ~ 30.0 parts, 1.0 ~ 5.0 parts, Fructus Citri sinensis powder, during preparation, first, by the fresh Stichopus japonicus pulled out from sea, clean, cut off, the ginseng body wall of removing internal organs, liquid containing holothurians autoenzyme in wall of sea cucumber Stichopus japonicus gives over to for subsequent use, and by the Intestinum Stichopi japonici in Stichopus japonicus internal organs and the impurity Ex-all in sea cucumber, Intestinum Stichopi japonici and sea cucumber are applied in the lump, by wall of sea cucumber Stichopus japonicus, Intestinum Stichopi japonici and sea cucumber grind making beating after pulverizing, add in enzymatic vessel, add the 5-10 water doubly of wall of sea cucumber Stichopus japonicus weight, add liquid containing holothurians autoenzyme in wall of sea cucumber Stichopus japonicus and food flavor enzyme appropriate, mix homogeneously, open steam cock, gradually 45-65 degree is warming up to, under the condition constantly stirred, maintain constant temperature 3.5-4 hour, treat that whole liquid is clarified substantially, be warming up to 100 degree, 5-10 minute, filter after cooling, by the liquid of above-mentioned gained, add water adjustment concentration, concentration is at 2%-10%, spray dry tower with cleaning and carry out spraying dry, spray powder is up to the standards, plastic bag evacuation is packed, cryopreservation, for subsequent use, then, by Saussurea involucrata culture raw material, vacuum drying is carried out at 60 degree, Saussurea involucrata culture raw material is qualified through chemically examining, through YSC-701 super micron mill, the fineness of the feature of the method is high, in crushing process, maximum temperature only has 45 degree, ensure that and the quality of raw material is not damaged, dust losses is atomic, and it is pollution-free.Get Folium Ginkgo extract qualified according to standard test functional component, detect the qualifieds such as heavy metal, finally, take Stichopus japonicus instant powder 45.0kg, Saussurea involucrata culture powder 50.0kg, Folium Ginkgo extract 25kg, each raw material of weighing, in three-dimensional mixer, mix homogeneously, the low alcohol of mixed raw material powder does wetting agent, and method of granulating is conveniently granulated, drying, gets Fructus Citri sinensis powder 5kg in proportion and is mixed in the granule made, mix homogeneously, tabletting, after the assay was approved, packaging.
Alkaloid is carried out to the tablet prepared and detects analysis, with the content of the colchicine in fluorescence spectrometry tablet, test method reference literature method " the colchicine assay laboratory 1999 in fluorescence spectrometry tablet, 03,74-76 " carry out detection analysis, testing result shows that the content of the colchicine of Stichopus japonicus Herba Saussureae Involueratae composite preparation of the present invention is 1mg/100mg, and this content has no side effect to human body.
Below experiment show a kind of Stichopus japonicus snow lotus health-preserving preparation of this invention to enhancing immunity, protect cardiovascular and cerebrovascular vessel, improve peripheral blood circulation, reduce serum cholesterol, physical strength reinforcing and anti-ly have obvious effect except fatigue.
1. physical strength reinforcing removes fatigue with anti-
Choose 60 of the same age and various biochemical indicators normal and identical male mice, be divided into four groups, often organize 15, one group is matched group, three groups is experimental group, the daily feedstuff of matched group diet, experimental group feeds these invention health preserving goods of various dose respectively, one group of 100mg/kg low amounts group, two groups of groups are amount group in 200mg/kg, three groups is 600mg/kg a large amount group, other feeding conditions and environment facies are together, after one month, swimming endurance experiment is done under identical water temperature, result shows the average swim persistent period: matched group 15 minutes, one group of low amounts group 38 minutes, amount group 50 minutes in two groups, three groups of a large amount groups 52 minutes, as can be seen here, each dosage group mice swimming time all extends than matched group, health product of the present invention have increases muscle power and enhancing body anti-fatigue ability.
2. improve immunity
Choose the of the same age and mice that various biochemical indicator is normal and identical of 60 mices, male and female half and half, be equally divided into four groups, often organize 15, one group is matched group, three groups is experimental group, the daily feedstuff of matched group diet, experimental group feeds these invention health preserving goods of various dose respectively, one group of 100mg/kg low amounts group, two groups of groups are amount group in 200mg/kg, three groups is 600mg/kg a large amount group, other feeding conditions and environment facies are together, after one month, often organize random selecting 10 mices, carry out asepticly getting spleen to mice, make single cell suspension, cell concentration is regulated to be 3 × 106/ml with RPMI1640 complete medium, the cell suspension of gained is joined in 24 porocyte culture plates, every hole 1mL, often kind of splenocyte suspension adds holes, every hole adds 75 μ L ConA liquid in addition, another hole adds mutually commensurability normal saline, put in 37 DEG C of 5%CO2 incubators and cultivate 72h.Cultivation terminates front 4h, every hole sucks supernatant 0.7mL gently, adds 0.7mL not containing the RPMI1640 culture fluid of calf serum, adds MTT(5mg/ mL simultaneously) 50 μ L/ holes, continue to cultivate 4h, after cultivation terminates, every hole adds 1 mL acid isopropyl alcohol, piping and druming mixing, purple crystal is dissolved completely, then be dispensed in 96 well culture plates, 3 parallel holes are made in each hole, measure the optical density value at 570nm place by microplate reader.Amount group 0.334, three groups of a large amount groups 0.368 in matched group optical density value 0.102, one group of low amounts group 0.352, two groups, as can be seen here, matched group and one group, two groups, three groups have notable difference, and between one group, two groups, three groups, difference is little;
Choose the of the same age and mice that various biochemical indicator is normal and identical of 60 mices, male and female half and half, be equally divided into four groups, often organize 15, one group is matched group, three groups is experimental group, the daily feedstuff of matched group diet, experimental group feeds these invention health preserving goods of various dose respectively, one group of 100mg/kg low amounts group, two groups of groups are amount group in 200mg/kg, three groups is 600mg/kg a large amount group, other feeding conditions and environment facies are together, after one month, often organize random selecting 10 mices, take mouse immune device spleen respectively, thymus, liver, weigh, matched group 5.632mg/g, one group of low amounts group 7.562 mg/g, amount group 8.053mg/g in two groups, three groups of a large amount group 7.651 mg/g, as can be seen here, matched group and one group, two groups, three groups of difference are very large, one group, two groups, between three groups, difference is little,
In sum, the present invention improving to obvious body immunity, has the function of enhancing immunity.
3. protect cardiovascular and cerebrovascular vessel, improve peripheral blood circulation, reduce serum cholesterol
For protection cardiovascular and cerebrovascular vessel, improve peripheral blood circulation, reduce effect of serum cholesterol, inventor finds 30 people and suffers from cardiovascular and cerebrovascular disease in various degree and Hyperlipidemia, through taking medicament blood pressure of the present invention, blood fat, blood glucose, cholesterol has reduction phenomenon and is tending towards normal person 21 people, blood pressure, blood fat, blood glucose, cholesterol normal person 7 people, blood pressure, blood fat, blood glucose, cholesterol has reduction phenomenon but effect undesirable person 2 people, and experimenter generally feels, along with the increase of edible time, not only blood fat, cholesterol has lowered, and health there has also been large increase, feeling dizzy of normal appearance in the past, the situation that afternoon easily tired night but regains consciousness disappears, action becomes sensitiveer, whole people is in high spirits to get up, and can also feel the raising of body immune ability significantly, even if also do not suffer from flu more popular season in flu, as can be seen here, the present invention is to protecting human body cardiovascular and cerebrovascular vessel, improve peripheral blood circulation, reduce serum cholesterol and have significant curative effect.
4. pair health preserving goods of the present invention carry out toxicological experiment
Choose the of the same age and mice that various biochemical indicator is normal and identical of 60 mices, male and female half and half, be equally divided into four groups, often organize 15, one group is matched group, three groups is experimental group, the daily feedstuff of matched group diet, experimental group feeds these invention health preserving goods of various dose respectively, one group of 100mg/kg low amounts group, two groups of groups are amount group in 200mg/kg, three groups is 600mg/kg a large amount group, other feeding conditions and environment facies are together, after one month, all there is not toxic reaction in four groups of rats, physically well develop, macroscopic appearance and main organs no abnormality seen, peripheral hemogram and Serum ALT, BUN compares with matched group and changes without pathologic, the pathological replacement heart, liver, spleen, lung, kidney, the all not significant change such as stomach, therefore, through proved by pathology, this invention shows animal avirulence.
Embodiment 1
Stichopus japonicus powder 20 parts, 70 parts, Saussurea involucrata culture powder, Folium Ginkgo extract 15 parts, 5 parts, Fructus Citri sinensis powder.
Embodiment 2
Stichopus japonicus powder 60 parts, 15 parts, Saussurea involucrata culture powder, Folium Ginkgo extract 25 parts, 5 parts, Fructus Citri sinensis powder.
Embodiment 3
Stichopus japonicus powder 50 parts, 50 parts, Saussurea involucrata culture powder, Folium Ginkgo extract 20 parts, 5 parts, Fructus Citri sinensis powder.
Embodiment 4
Stichopus japonicus powder 30 parts, 25 parts, Saussurea involucrata culture powder, Folium Ginkgo extract 25 parts, 5 parts, Fructus Citri sinensis powder.
Embodiment 5
Stichopus japonicus powder 80 parts, 85 parts, Saussurea involucrata culture powder, Folium Ginkgo extract 15 parts, 5 parts, Fructus Citri sinensis powder.
Crowd's test-meal result
1. follow the tracks of 45 routine patients, this 45 routine patient, immunity is low, and namely weather slightly changes catches a cold, flat
Within equal 1-2 month, catch a cold once, take health preserving goods of the present invention before sleeping every day, after taking 2 months, immunity improves, and can resist the change of weather, number of times of catching a cold obviously reduces.
2. permitted certain, people from Shandong, because operating pressure increases, usually insomnia and dreamful sleep, immunity degradation, weak all over, after taking Stichopus japonicus snow lotus health-preserving preparation of the present invention, complexion is obviously ruddy, and resistance improves, and has vigor.
3. Cai, people from Shandong, female, anxious state of mind, insomnia, hypomnesis, menoxenia, hyposexuality, mastatrophy, skin become coarse dark and gloomy, elasticity attenuation, corse sweat pore, wrinkle intensification.Through taking Stichopus japonicus snow lotus health-preserving goods of the present invention after one month, sleep quality is good, and sleep is dark, and memory increases, eumenorrhea skin is ruddy, glossy, and skin is flexible, and wrinkle reduces.
4. Hu, people from Shandong, hyperlipemic patients, through taking Stichopus japonicus snow lotus health-preserving goods of the present invention after two months, check, blood viscosity reaches normal value.
5. Wang, man, 56 years old, suffers from hyperlipidemia, hypertension, hyperglycemia 6 years, and within 2010, check, T-CHOL value is 8.1mmol/L, and take continuously through taking Stichopus japonicus snow lotus health-preserving goods of the present invention, T-CHOL value reduces to 6.9mmol/L.
As can be seen here, through taking Stichopus japonicus snow lotus health-preserving goods of the present invention, to enhancing immunity, protecting cardiovascular and cerebrovascular vessel, improve peripheral blood circulation, reduce serum cholesterol, physical strength reinforcing and anti-ly have obvious effect except fatigue.

Claims (8)

1. the composite preparation of a Stichopus japonicus Herba Saussureae Involueratae, it is characterized in that being made up of Stichopus japonicus, Herba Saussureae Involueratae, Folium Ginkgo extract and Fructus Citri sinensis powder, wherein the weight proportion of Stichopus japonicus, Herba Saussureae Involueratae, Folium Ginkgo extract and each component of Fructus Citri sinensis powder is: Stichopus japonicus 5.0 ~ 90.0 parts, Herba Saussureae Involueratae 5.0 ~ 90.0 parts, Folium Ginkgo extract 10.0 ~ 30.0 parts, 1.0 ~ 5.0 parts, Fructus Citri sinensis powder.
2. the composite preparation preparation method of a Stichopus japonicus Herba Saussureae Involueratae, it is characterized in that the fresh Stichopus japonicus first will pulled out from sea, clean, cut off, the ginseng body wall of removing internal organs, liquid containing holothurians autoenzyme in wall of sea cucumber Stichopus japonicus gives over to for subsequent use, and by the Intestinum Stichopi japonici in Stichopus japonicus internal organs and the impurity Ex-all in sea cucumber, Intestinum Stichopi japonici and sea cucumber are applied in the lump, by wall of sea cucumber Stichopus japonicus, Intestinum Stichopi japonici and sea cucumber grind making beating after pulverizing, add in enzymatic vessel, add the 5-10 water doubly of wall of sea cucumber Stichopus japonicus weight, add liquid containing holothurians autoenzyme in wall of sea cucumber Stichopus japonicus and food flavor enzyme appropriate, mix homogeneously, open steam cock, gradually 45-65 degree is warming up to, under the condition constantly stirred, maintain constant temperature 3.5-4 hour, treat that whole liquid is clarified substantially, be warming up to 100 degree, 5-10 minute, filter after cooling, by above-mentioned gained liquid, add water adjustment concentration, concentration is at 2%-10%, spray dry tower with cleaning and carry out spraying dry, spray powder is up to the standards, plastic bag evacuation is packed, cryopreservation, for subsequent use, then, by Saussurea involucrata culture raw material, vacuum drying is carried out at 60 degree, Saussurea involucrata culture raw material is qualified through chemically examining, through YSC-701 super micron mill, in crushing process, maximum temperature only has 45 degree, get Folium Ginkgo extract qualified according to standard test functional component, detect the qualifieds such as heavy metal, finally, take Stichopus japonicus instant powder 5.0 ~ 90.0 parts, 5.0 ~ 90.0 parts, Saussurea involucrata culture powder, Folium Ginkgo extract 10.0 ~ 30.0 parts, , the each raw material weighed, in three-dimensional mixer, mix homogeneously, the low alcohol of mixed raw material powder does wetting agent, method of granulating is conveniently granulated, dry, getting 1.0 ~ 5.0 parts, Fructus Citri sinensis powder is in proportion mixed in the granule made, mix homogeneously, tabletting, after the assay was approved, packaging, finally by fluorescence method, Colchicine Content in preparation is measured.
3. the composite preparation of a kind of Stichopus japonicus Herba Saussureae Involueratae according to claim 1, is characterized in that Herba Saussureae Involueratae is prepared by Saussurea involucrata culture.
4. a kind of Stichopus japonicus Herba Saussureae Involueratae composite preparation according to claim 2, is characterized in that making powder, granule, capsule, tablet, is preferably tablet, granule.
5. a kind of Stichopus japonicus Herba Saussureae Involueratae composite preparation according to claim 4, is characterized in that tablet is prepared into confection tabletting, chewable tablet, effervescent tablet.
6. a kind of Stichopus japonicus Herba Saussureae Involueratae composite preparation according to claim 4, is characterized in that capsule is prepared into hard capsule preparation and soft capsule preparation.
7. a kind of Stichopus japonicus Herba Saussureae Involueratae composite preparation according to claim 4 or 6, it is characterized in that soft capsule preparation adds salad oil by the mixture of Stichopus japonicus instant powder, Saussurea involucrata culture powder and Folium Ginkgo extract to grind evenly, mixture and salad oil ratio are 1:3.
8. a kind of Stichopus japonicus Herba Saussureae Involueratae compositions according to claim 1, is characterized in that applying preparing in enhancing immunity health product.
CN201410532790.8A 2014-10-11 2014-10-11 Sea cucumber and saussurea involucrata composition preparation and preparation method thereof Pending CN104352542A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104839737A (en) * 2015-04-22 2015-08-19 云南尚源生物科技有限公司 Sport nutrition food
CN108835638A (en) * 2018-08-01 2018-11-20 黑龙江仁合堂药业有限责任公司 A kind of Soboring-up liver-protecting improves the food and preparation method thereof of immunity

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CN101073432A (en) * 2006-05-16 2007-11-21 尚玉芝 Saussurea involucrata ginkgo health-care tea and its production
CN103610065A (en) * 2013-12-11 2014-03-05 威海力元海洋生物科技有限公司 Sea cucumber and maca composition and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101073432A (en) * 2006-05-16 2007-11-21 尚玉芝 Saussurea involucrata ginkgo health-care tea and its production
CN103610065A (en) * 2013-12-11 2014-03-05 威海力元海洋生物科技有限公司 Sea cucumber and maca composition and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104839737A (en) * 2015-04-22 2015-08-19 云南尚源生物科技有限公司 Sport nutrition food
CN108835638A (en) * 2018-08-01 2018-11-20 黑龙江仁合堂药业有限责任公司 A kind of Soboring-up liver-protecting improves the food and preparation method thereof of immunity

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Application publication date: 20150218