CN1408397A - Composition containing melatonin and galangal fruit traditional Chinese medicine - Google Patents
Composition containing melatonin and galangal fruit traditional Chinese medicine Download PDFInfo
- Publication number
- CN1408397A CN1408397A CN 01141454 CN01141454A CN1408397A CN 1408397 A CN1408397 A CN 1408397A CN 01141454 CN01141454 CN 01141454 CN 01141454 A CN01141454 A CN 01141454A CN 1408397 A CN1408397 A CN 1408397A
- Authority
- CN
- China
- Prior art keywords
- radix
- melatonin
- chinese medicine
- fructus alpiniae
- alpiniae oxyphyllae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to one Chinese medicine composition containing melatonin and galangal fruit and aims at providing a kind of composition with medicinal value of treating insomina and hypomnesia of people in different age. The Chinese medicine composition has also the functions of regulating immunity, resisting free radical damage, improving cardiac and cerebral blood supply, resisting tumor, resisting fatigue and remitting mental pressure. The present invention has high biological utilization and no medicine dependence.
Description
The present invention relates to contain the compositions of melatonin and Fructus Alpiniae Oxyphyllae Chinese medicine.Be in the Fructus Alpiniae Oxyphyllae Chinese medicine preparation, to add an amount of melatonin exactly, be used to improve sleep and cardiac and cerebral blood-supply, memory reinforcing, human body immunity improving power, alleviate health care, the medicine of stress etc.
Along with the development of progress of productivity, society, people's rhythm of life is accelerated, operating pressure increases, and increasing people is bearing puzzlements such as insomnia, hypomnesis, many diseases and stress are big.Though the medicine on the market is a lot of now, takes weak curative effect for a long time, side effect is many, in order to change this situation, brings into play the Chinese medicine advantage of China, and we have invented a kind of compositions with medical value.
Prescription is formed: Radix Ginseng 15g, Rhizoma Acori Graminei 20g, Radix Polygalae 20g, Poria 20g, Radix Rehmanniae Preparata 12g, Semen Platycladi 10g, Radix Ophiopogonis 15g, Rhizoma Chuanxiong 20g, Semen Ziziphi Spinosae 18g, Rhizoma Polygonati (processed) 10g, Radix Polygoni Multiflori 12g, Radix Astragali 15g, Rhizoma Cyperi 8g, Cortex Acanthopancis 15g, Caulis Polygoni Multiflori 10g, Rhizoma Polygonati Odorati 15g, Radix Glycyrrhizae 8g, taking melatonin 0.5mg/ sheet or every day overall control is 3mg～5mg scope.
The object of the present invention is to provide a kind of compositions with medical value of science, its major function is calming soporific and hypermnesis, for people's insomnia, hypomnesis provide health care, treatment.Except regulating sleep and hypermnesis, it also has the immunity regulated, free radical resisting damage, improves the effect of cardiac and cerebral blood-supply, antitumor, resisting fatigue, alleviation stress.
Prescription of the present invention be according to traditional Chinese medical science traditional theory in conjunction with the modern Chinese medicine achievement in research, adopting the melatonin of Chinese herbal medicine and synthetic is that feed purification forms, and does not contain human body harmful's composition, and human body is had no side effect.
Prescription of the present invention respectively distinguish the flavor of the mutual synergism of Chinese medicine, promote mutually good absorbing, bioavailability height, determined curative effect.
Melatonin is the synthetic and excretory neuro-endocrinology hormone of pinus, and chemical name is a melatonin, and body is had wide influence, has neuroendocrine system, reproductive system and the functions of immune system of adjusting.Its major function has: 1, regulate the clear-headed sleep cycle of human body, can induce physiologic sleep, treat various insomnias; 2, anti-aging effects.By powerful antioxidation, influence biological clock, regulate the inflammation immunoreation and influence the hormone secretion effect, play anti-aging effects; 3, antitumor action.The generation of tumor and the autoimmune of human body monitor, factors such as influence old and feeble, extraneous toxicant are closely related, and melatonin can play a role in these areas; 4, prevention and treatment alzheimer disease, alzheimer disease factors such as apoptosis disorderly with central nervous system's mediator and axoneuron are relevant, and melatonin then can be regulated the function of mediator system and prevent apoptosis in neuronal.Chinese medicine Radix Ginseng, Rhizoma Acori Graminei, Poria, Radix Polygalae, Rhizoma Chuanxiong, Semen Ziziphi Spinosae, Radix Polygoni Multiflori, Radix Ophiopogonis, Rhizoma Polygonati (processed), Rhizoma Polygonati Odorati, Semen Sesami Nigrum, the Radix Astragali, Rhizoma Cyperi, Radix Rehmanniae Preparata, Semen Platycladi, Caulis Polygoni Multiflori, Cortex Acanthopancis be Fructus Alpiniae Oxyphyllae, calm the nerves, relieving restlessness, the class that clears away heart-fire medicine, and they have the modern medicine study proof and improve memory, regulate immunity, improve blood supply, improve effects such as the work of brain and stress ability.Chinese medicine and human hormone are used, can play synergism, improve their effect, reach the purpose of improving sleep, improving memory, enhancing human brain ability to work, antitumor and slow down aging.
(Melatonin MT) mainly originates from pinus to melatonin, very easily by blood brain barrier, has the free radical of removing, suppresses lipid peroxidation, strengthens activities of antioxidant enzymes and/or antioxidase gene expression, regulates multiple functions such as immunity and biological clock.Along with the age increases, Alzheimer disease (AD) sickness rate raises, and the level of MT descends in patient's blood and the cerebrospinal fluid, the physiological rhythm disorder, and hypopinealism causes the MT secretion and reduces the morbidity that has participated in AD.MT can suppress the neurotoxic effect of amyloid-beta by many approach, can prevent neuronal apoptosis, and senile dementia or parkinson are had therapeutic value.To be body lose adaptive capacity to environment gradually with the growth at age in aging, and this process makes the ability of body opposing destructive stimulus reduce with the change of behavior, endocrine and other physiological functions, and the susceptibility of disease is increased.Pineal function changes with the increase at age, and parallel with the process of aging, and the age increases the pineal gland calcification rate and increases, and its biosynthesis and secretory function reduce, and pineal gland is transplanted the aging that can delay animal.The life cycle of exogenous melatonin energy prolong rats, and the time of origin of deferrable rabbit Senile disease.Among the human aging process; the damage of radical pair tissue also is a factor that can not be ignored; discover that pineal gland and melatonin slow down aging have anti-radical action with it; regulate the inflammation immunoreation; regulate biological clock; influencing hormone secretion stress wait function relevant with participating in; melatonin can be from a plurality of link control radical damages; it can directly remove free radical; suppress lipid peroxidation; the protection biomacromolecule; the protection nucleus DNA; membrane lipid; biomacromolecules such as plasmosin are avoided oxidative damage; and with other antioxidant synergism, born the anti-oxidative defense function of body jointly.And the old and feeble just key character of the susceptibility increase of radical scavenging activity reduction in the senile organism, hormone secretion disorder, biological clock decline, tumor and other diseases.Recently find that the excretory melatonin of pineal gland is a kind of than more effective free radical scavenger of vitamin E and antioxidant.It can be directly in and hydroxy radical and peroxylradicals, can also suppress the activity of nitricoxide synthase by activating glutathion peroxidase, play indirect antioxidative effect, be the strongest free radical scavenger of present known antioxidation.That melatonin has is nontoxic, easily penetrate the dissect physiology barrier and enter the characteristics of subcellular component.It can directly deactivation toxicity free radical, and obvious enhancing body anti-oxidative defense system.Experiment showed, melatonin can antagonism oxidisability hepatic injury due to the yellow Camphor tree essence of carcinogen, N,N'-dimethyl-.gamma..gamma.'-dipyridylium and the lipopolysaccharide, protect nucleus DNA and lipid film to avoid oxidative damage effectively.In addition, find that also melatonin can promote that rat hepatectomizes the regenerated while, influence lymphocyte subgroup and distribute, regulate liver drug metabolism enzyme and prevent thymocyte apoptosis.These result of study promptings, the neuroimmunomodulation of melatonin also have the body of being beneficial to opposing oxidative damage.Endogenous MT can not induce an illness completely, gives the generation that exogenous MT then can delay disease.
Radix Ginseng removes pathogen, makes eye bright, happy Fructus Alpiniae Oxyphyllae.The mechanism of its Fructus Alpiniae Oxyphyllae mainly is that the good tonification function of five internal organs that had with it is relevant.Ming Dynasty's " Required Readings for Medical Professionals " says, Radix Ginseng get positive and gas, can return vigour and die in meeting, the then refreshing peace of gas foot, just prosperous then heresy is gone, the motive then is apt to think of and many intelligence by force.Radix Ginseng master tonifying five ZANG-organs is because the five internal organs belong to cloudy cause, sees that spirit is uneasy, and palpitation with fear is more than, and order is not clear, and intelligence is insufficient, all is that the deficiency of YIN is created disturbances to caused by excited yang-energy.The five internal organs get sweet cold the helping of Radix Ginseng, just can bring into play well peace, calmly it, only it, bright it, rise it, benefit effect.Modern study confirms that Radix Ginseng is to the central nervous system, and particularly there is certain specific action at its senior position, mainly is to strengthen corticocerebral process of excitation, also can strengthen process of inhibition simultaneously, improves the motility of neural activity process.It can also improve people's the general mentality and the function of muscle power, and significant antifatigue effect is arranged.
Cortex Acanthopancis is an Araliaceae.The nature and flavor suffering, temperature is returned through going into liver, kidney channel.The effect replenishing QI to invigorate the spleen, the kidney invigorating Fructus Alpiniae Oxyphyllae, strengthening bone and muscle, wind-damp dispelling.Cure mainly soreness of waist and knee joint, the muscles and bones contracture, stride is weak, insomnia forgetfulness, edema beriberi etc.Cortex Acanthopancis contains acanthoside A, B, B1, C, D, E.F.G, left-handed sesamin, polysaccharide etc.Good defying age, strong, antifatigue effect are arranged on the pharmacology, descend or meet added burden and when special requirement is arranged at Abwehrkraft des Koepers, can physical strength reinforcing or the usefulness of brainwork.The effect that has the nervous system regulation function simultaneously, it both can strengthen neural process of excitation, can strengthen its process of inhibition again, thereby made neural these two processes be in poised state, thereby played brain-tonifying effect preferably.
Radix Rehmanniae is scrophulariaceae rehmannia glutinosa plant or bosom celebrating Radix Rehmanniae rhizome, if shine just ripe Radix Rehmanniae through the processing steaming.Radix Rehmanniae Preparata is sweet, tepor; Go into liver, kidney channel.The Radix Rehmanniae Preparata nourishing YIN and supplementing blood increases intelligence, with controlling dizziness and tinnitus, palpitation and insomnia, strong will seminal emission.Composition mainly contains B sitosterol, mannitol, stigmasterol, campesterol, rehmanin, alkaloid, fatty acid, catalpol, glucose, vitamin A etc.Blood sugar lowering is arranged on the pharmacology, boost and diuresis, the energy the liver protecting prevents liver glycogen minimizing etc.The sweet greasy thick taste of Radix Rehmanniae Preparata, tonification power is strong, and promoting generation of vital essence and blood is filled out bone marrow, fills brain, and the audition improvement order nourishes heart and allays excitement, and is applicable to that the empty partially person of cloudy blood takes.Forefathers once also claimed it and Radix Ginseng, meaning Radix Rehmanniae Preparata nourishing YIN blood, Radix Ginseng YANG invigorating gas.
Radix Ophiopogonis is the tuber of liliaceous plant dwarf lilyturf.Sweet, the little hardship of nature and flavor; Cold; Gui Jing goes into the heart, lung, stomach warp.Effect is a nourishing YIN and moistening the lung, the Fructus Alpiniae Oxyphyllae that clears away heart-fire, the relieving restlessness of promoting the production of body fluid.Cure mainly consumption of body fluid caused by febrile disease, the asthenia dysphoria with smothery sensation, the dryness of the intestine sleeplessness, forgetful.Composition contains multiple steroid saponin, is called ophiopagonin A, B, C, D etc. respectively.Also contain Sitosterolum, stigmasterol, aminoacid, glucose, vitamin A.Blood sugar lowering is arranged on the pharmacology, impel insulin cell to recover, increase the effect of liver glycogen.The heart nourishing and intellengence improving effect of Radix Ophiopogonis really can be gone into the heart except that it and be nourished heart, and outside the performance nootropic effect, mainly has good YIN nourishing and the production of body fluid promoting function relevant with it.The people has depression slightly, and the heart is subjected to it earlier, and fire is from interior life, dysphoria with smothery sensation; Insomnia, forgetful, malaise rises thereupon.Radix Ophiopogonis can YIN nourishing Tianjin, arrogate to oneself clearind deficient heat, cloudy Tianjin is filled, deficiency-heat is gone, the mind can pacify and.
Semen Ziziphi Spinosae is the seed of Rhamnaceae plant Ziziphi Spinosae.Nature and flavor are sweet, and are flat; Gui Jing goes into the heart, spleen, liver, gallbladder meridian.Effect is the mind tranquilizing and the heart calming brain-strengthening, the nourishing the liver arresting sweating.Cure mainly empty meal sleeplessness, the palpitation with fear palpitation with a distress feeling, forgetful, dizzy, excessive thirst, sweating due to debility.Contain fatty oil, protein, betulin, betulic acid, jujuboside, sterol in the composition, also have a large amount of vitamin Cs.Tangible calmness, syngignoscism are arranged on the pharmacology, fall the blood effect significantly, also have effects such as analgesia, convulsion, cooling.It can be calmed the nerves by astringing QI, and flourish muscle is supported marrow, the stomach function regulating activating the spleen, and warming middle-JIAO and wet, the astringing QI hidroschesis, beneficial will is breathed out surely, hearing-improing and eyesight improving.Certainly, the effect that Semen Ziziphi Spinosae is the most outstanding, also being nourishes heart allays excitement, and it has the good sedative sedative action, is the active drug of regulating the central nervous system.Semen Ziziphi Spinosae can be calmed the nerves, and can promote sound sleep, and ancients praise its nationality perfume (or spice) highly with the saturating heart, warm with aroused in interest spleen, the bitter blood trouble of all will is decreased refreshingly with intelligence, cause the deficiency of having a guilty conscience, the spirit fall, palpitation with fear, in a trance poor memory, the sweating due to debility excessive thirst, work as and must use.As milk-livered insufficiency of blood, dysphoria and insomnia can make the liver and gall hemapodium with this, then five victorys peaces and, doss rather.Fragrance is gone into spleen, and the moon of being amusing with controlling worry impairing spleen, all can prove effective.
Semen Platycladi is the kernel of Cupressaceae plant Cacumen Platycladi.Nature and flavor are sweet, and are flat; Gui Jing goes into the heart, liver, spleen channel.Effect is a tranquilizing by nourishing the heart, and nourishing kidney is moisturized, Fructus Alpiniae Oxyphyllae supplementing the brain, loosening bowel to relieve constipation.Cure mainly palpitation with fear, insomnia, forgetful, night sweat, seminal emission, constipation etc.Composition contains fatty oil, volatile oil and Saponin etc.Compendium of Material Medica: " gas that nourishes heart, the profit kidney is dry, and the peace soul is decided soul, Fructus Alpiniae Oxyphyllae is allayed excitement ".Semen Platycladi is flat and cold not dry, sweet in the mouth and mending, and the Xin Erneng profit, its gas delicate fragrance can saturating heart kidney, the strengthening the spleen stomach, it is top grade to belong to celestial family.Semen Platycladi is gone into the heart, and tranquilizing by nourishing the heart is preferably arranged, the brain healthy function, and the flat lung benefiting gas of gas, sweet in the mouth strengthening the spleen gas moistens the beneficial motive.Its flat sweet tonifying YIN, bright foot then the five internal organs can both pacify and.The beneficial blood of clothes makes complexion be full of brilliance for a long time.The heart being a vital viscus like a king of the body, the bright then twelve interior organs of heart master all must be with suitable, and ear can be clever, and order can be bright.So Semen Platycladi can be brought into play good happy spleen, nourishes heart, moistens kidney, liver nourishing, Fructus Alpiniae Oxyphyllae, the effect of allaying excitement.
Rhizoma Acori Graminei is the acorus gramineus araceae plant rhizome.The nature and flavor suffering, tepor; Gui Jing goes into the heart, liver, spleen channel.Effect is an inducing resuscitation, the eliminating phlegm Fructus Alpiniae Oxyphyllae, and invigorating blood and dispelling wind goes in the gentleness.Cure mainly coma, insane pain, syncope due to accumulation of phlegm, forgetful, deafness, ambition unhappiness, gastral cavilty stomachache, anemofrigid-damp arthralgia.Compendium of Material Medica: " clothes are not forgotten without doubt for a long time for happy hole, logical nine orifices ".The comfortable gas of Rhizoma Acori Graminei, the smooth mind, happy mood, beneficial will.Rhizoma Acori Graminei is heart channel medicine, and the magical effect of the mind calming and mentality promoting is arranged.Why it can play effect like this, is to open because of its suffering warm in nature, and it is turbid by expectorant to dispel, and makes the cardio cerebral function obstacle that causes because of the turbid retardance of expectorant obtain correcting.Rhizoma Acori Graminei is hot can using pungent drugs for dispersion and bitter drugs for purgation, and temperature wins raw, the long-pending drink of all retention of phlegm, turbid damp is hoodwinked, the thoracic obstruction stagnation of QI, the dirty or Huang Houzhe of the first white greasy dirt of tongue, non-this fragrant sharp key can not be dredged, non-lung dryness of the stomach cough and the cough with dyspnea of suffering from a deficiency of the kidney comparable.Happy hole, the tonifying five ZANG-organs person also is jammed so that expectorant is turbid; Purge away depravity, the then logical spirit of nine orifices, and win the contented tonification of gas, and the thing of non-warm-dryness syndrome, the energy tonifying five ZANG-organs is very also bright.And the gas of delicate fragrance, the spirit of bestirring of helping others is so make normal hearing and eyesight, the nine orifices tonneau.
Radix Polygalae is the root of milk wort spire Radix Polygalae.Nature and flavor hardship, suffering, temperature; Gui Jing goes into the heart, kidney channel.Effect is the Fructus Alpiniae Oxyphyllae of calming the nerves, and resolving depression eliminates the phlegm.It is not peaceful to cure mainly palpitation with fear, the insomnia nocturnal emission, and forgetful god is tired, cough ant phlegm.Contain Saponin in the composition, can get 2 kinds of ruscogenin crystallizations after the hydrolysis, presenegenin A and presenegenin B, other contains glycoside, polygalytol, N acetic acid glucosamine etc.Eliminating the phlegm arranged on the pharmacology, strengthen the effect of hypnotic, also have effects such as convulsion.Shennong's Herbal: " the contrary damaging the spleen and stomach of main tunnel, tonifying for the deficiency removes pathogen, sharp nine orifices, Fructus Alpiniae Oxyphyllae is intelligent, normal hearing and eyesight is not forgotten, the strong power of strong will ".Radix Polygalae is the Fructus Alpiniae Oxyphyllae key medicine of calming the nerves, and is good at controlling the card of palpitation with fear, forgetful, nocturnal emission, all irritability of insomnia, the hypophrenia.Motherland's medical science thinks that The heart controls mental activities, and the relation of all the mind activities and the heart is very close, and the functional activity of the heart is normal, then gods spirit clearly, and thinking is quick.Any reason causes the functional activity of heart and brain not normal, then gods disturbance, and heart owner of lost property department considers not normal.Radix Polygalae is gone into the heart, kind warm heart-yang, and centering gas, relieving palpitation exorcises evil spirits, so can play the nootropic effect of calming the nerves preferably.Radix Polygalae flavor bitter in taste acting on the heart, the temperature promoting the circulation of blood, and fragrance is cool, edema caused by disorder of QI can pass through again.Special main heart channel person, the aggregation of this blood of the heart, Xin Wen with tonneau it, should its heart-yang of bestirring oneself, and beneficial people's wisdom; So-called peace soul, the arresting convulsion person of throbbing with fear, also meaning subsidy heart-yang, then the motive fill and the soul dream from peaceful, palpitation with fear is made by oneself.As seen the merit of the Fructus Alpiniae Oxyphyllae of calming the nerves of Radix Polygalae is to be that it goes into heart channel and work by the heart.
The Poria nature and flavor are sweet, light, and are flat.Gui Jing goes into the heart, spleen, kidney channel.Effect is the mind tranquilizing and the heart calming Fructus Alpiniae Oxyphyllae, the spleen invigorating eliminating dampness and diuresis.Cure mainly palpitation with fear and be insomnia, forgetful dizziness, seminal emission stranguria with turbid discharge.Contain acetic acid pachymic acid, pachymic acid, protein, fat, sterol, lecithin, glucose, gland in the composition and look sidelong at cry of certain animals, histidine, choline, protease etc.Effects such as diuresis, anticancer, calm, blood sugar lowering are arranged on the pharmacology, heart tonifying is arranged, improve effect such as body's immunological function.Poria is used as medicine, history is very long, Poria has good tonic function, in recent years research data shows, Poria contains the important substance lecithin of participating in defying age process, nourishing the brain and improving intelligence in the body directly, also contain requisite protein, glucose and inorganic salt in the vital movement, and can enhancing body resist the polysaccharide of pathogenic factor ability, the material base as health care's medicine is arranged.Ancients explain its Fructus Alpiniae Oxyphyllae mechanism, can go into the heart, spleen, kidney from it, the wet logical thinking lexical or textual analysis of kind diuretic, logical really flat opinion.Poria is gone into the few sun of brothers, the hands sun, lunar, the Yangming Channel of foot.Its sweet energy invigorating middle warmer, light and sharp key, invigorating middle warmer is heart excess syndrome then, and sharp key then pathogenic heat is separated, and heart excess syndrome then melancholy compassion is certainly only shied heresy.Can make old people's ataraxy, sleep steadily improves the cardiopalmus symptom, improves the function of brain, memory reinforcing.
Science of TCM formulas thinks that prescription is to grow up on the basis of medicine, same Fructus Alpiniae Oxyphyllae prescription also is developed on the basis of Fructus Alpiniae Oxyphyllae Chinese medicine.Supplement to Thousand Golden Prescriptions has compiled the stronger nootropic drug of specific aim, and medicines such as Radix Polygalae, Rhizoma Acori Graminei, Poria, Radix Ginseng are listed under the amnesia.Song Jinyuan period and period of Ming and Qing have further developed Chinese medicine Fructus Alpiniae Oxyphyllae prescription, they with Radix Ophiopogonis, Fructus Alpiniae Oxyphyllae, Radix Polygoni Multiflori, Rhizoma Polygonati, Semen Ziziphi Spinosae, Rhizoma Chuanxiong, the Radix Rehmanniae etc. also as Fructus Alpiniae Oxyphyllae class common drug.We select first-class Chinese crude drug for use in conjunction with the Fructus Alpiniae Oxyphyllae experience of traditional traditional Chinese medical science and the achievement in research of modern Chinese medicine effective ingredient, utilize modern science and technology, add necessary refining the forming of the hormone of sleeping peacefully of human body self.
Embodiment 1. concentrated tablets are studied the mice sedative-hypnotic effect
Chinese herbal medicine:
Radix Ginseng 1500g Rhizoma Acori Graminei 2000g Radix Polygalae 2000g Poria 2000g
Radix Rehmanniae Preparata 1200g Semen Platycladi 1000g Radix Ophiopogonis 1500g Rhizoma Chuanxiong 2000g
Semen Ziziphi Spinosae 1800g Rhizoma Polygonati (processed) 1000g Radix Polygoni Multiflori 1200g Radix Astragali 1500g
Rhizoma Cyperi 800g Cortex Acanthopancis 1500g, Caulis Polygoni Multiflori 1000g Rhizoma Polygonati Odorati 1500g Radix Glycyrrhizae 800g
Human hormone (synthetic material):
Melatonin 5g preparation method:
With 80% decocting of above-mentioned Chinese medicine total amount, collect decocting liquid, vacuum drying is pulverized, and makes the water boiling concentration powder.In addition 20% superfine grinding is sieved, and adds the melatonin powder then, the water boiling concentration powder fully mixes, and adds an amount of excipient, tabletting, and every heavily about 500mg contains melatonin 0.5mg.Make 10000 altogether.
The major function of this compositions is for regulating sleep and hypermnesis, in order to verify the effect of calming soporific, and the syngignoscism after we have checked said composition to the effect of mice sub-threshold dose pentobarbital sodium.Concrete experimental technique is as follows:
With 30 of 20-26g Kunming mouses (male and female half and half), be divided into 3 groups at random, normal saline group (blank group), melatonin group (0.08mg/kg), compositions group (being equivalent to crude drug 10g/kg), each organized according to dosage gastric infusion after 1 hour, lumbar injection pentobarbital sodium (25mg/kg, the hypnosis sub-threshold dose), observes the number of elements of 30 minutes mice righting reflex loss more than 1 minute, analyze with the definite probability inspection method of four fold table.
Found that melatonin and compositions all have the good sedative soporific function, compare that having has significant difference (p＜0.01) on the statistics with the normal saline matched group.Although melatonin is compared there was no significant difference with the compositions group, we can find, use composition effect to be better than simple use melatonin (seeing table 1 for details).
Table 1. Kunming mouse is to the effect of sub-threshold dose pentobarbital sodium hypnotic
The sleeping rate (%) of the sleeping number of medicine n dosage (mg) (only)
Matched group 10 capacity such as grade 1 10%
Melatonin group 10 0.08mg/kg 5* 50%
Compositions group 10 10g/kg 7** 70%
Compare with normal saline, * p＜0.05, * * p＜0.01 embodiment, 2. compositions electuaries are to the Chinese herbal medicine that influences of learning and memory in rats ability: Radix Ginseng 750g Rhizoma Acori Graminei 1000g Radix Polygalae 1000g Poria 1000g Radix Rehmanniae Preparata 600g Semen Platycladi 500g Radix Ophiopogonis 750g Rhizoma Chuanxiong 1000g Semen Ziziphi Spinosae 900g Rhizoma Polygonati (processed) 500g Radix Polygoni Multiflori 600g Radix Astragali 750g Rhizoma Cyperi 400g Cortex Acanthopancis 750g, Caulis Polygoni Multiflori 500g Rhizoma Polygonati Odorati 750g Radix Glycyrrhizae 400g melatonin 5g preparation method:
JIANGCAO liquid medicine is fried in shallow oil (Radix Ginseng is fried in shallow oil in addition), the receipts decocting liquid is about 1/10 times of former dose, filter, it is 1.1～1.2 that the filtrate cryoconcentration causes proportion, is cooled to room temperature, add 95% ethanol, make that amount of alcohol reaches 70% in the medicinal liquid, left standstill the leaching supernatant 24 hours, cryoconcentration to proportion is about 1.4, and is standby.Add melatonin, reach an amount of Icing Sugar, dextrin, mix soft material, pushed 14～16 mesh sieves and make granule, 50～60 ℃ of oven dry, granulate, aseptic subpackaged.Every bag of 10g is equivalent to former medical herbs 50g and melatonin 1.5mg approximately.
In order to check the hypermnesis effect of compositions, we have observed the influence of this compound preparation to the rat memory function.Concrete grammar is as follows:
The Wistar rat, 18 monthly ages, body weight 200～260g, totally 40, male and female half and half.Rat is divided into four groups at random, promptly normal control group (negative control), model group, experimental group (be compositions electuary group, be equivalent to crude drug 7.5g/kg), piracetam group (positive control, 0.3g/kg).Model group and normal control group are irritated the normal saline of capacity such as stomach every day.The scopolamine dysmnesia model make the reference literature method carry out (the herbal pharmacology methodology. front page. Shanghai Science Press, 1991.171).The memory state of animal is observed in " Y " type of utilization labyrinth.Experimental result shows that the memory of rat obviously descends after the modeling, with significant difference on the normal group comparative statistics.Piracetam is a kind of medicine that can improve brain function of thinking traditionally, and clinical practice is extensive.Give the memory that compositions electuary and piracetam all can improve rat model, illustrate that this compound preparation has the effect that improves memory, compare with model group to have significant difference (seeing Table 2).
Table 2 compositions electuary is to the influence of the memory of dysmnesia rat due to the scopolamine
Group dosage/g.kg
-1The correct number of times accuracy of n normal control group isometric(al) 5 10.10 ± 2.05* 68.54 ± 11.30* model group isometric(al) 8 5.96 ± 1.20 40.65 ± 12.66 compositions electuary group 7.5g/kg 8 10.25 ± 2.66* 69.74 ± 15.23* piracetam group 0.3g/kg 9 9.32 ± 2.50* 66.81 ± 14.57* annotates: compare * p＜0.01 with model group
We find that this compositions has good nourishing the brain and improving intelligence effect from The above results, can sleep with improving by hypermnesis, have compared significant difference with model group, reach the normal control level.Polysaccharide in the Chinese medicine ingredients in this prescription, aminoacid, sterol, Saponin class, lipid also have the body metabolism of adjusting, microcirculation improvement, the neural effect of trophic centre.Add melatonin, further strengthen its function of sleeping peacefully, and the defying age of performance melatonin, prevent radical damage, antineoplastic action.
Claims (7)
1, a kind of compositions of being made up of melatonin and Fructus Alpiniae Oxyphyllae Chinese medicine, wherein the feature of Fructus Alpiniae Oxyphyllae Chinese medicine is: contain Radix Ginseng 10～20g, Rhizoma Acori Graminei 12～25g, Poria 10～25g, Radix Polygalae 10～30g, Radix Ophiopogonis 10～30g, Semen Ziziphi Spinosae 10～30g in single agent Chinese prescription.Add melatonin by the dosage requirement of taking 3～5mg every day in the Fructus Alpiniae Oxyphyllae Chinese medicine after the processing.
2, according to right 1, the melatonin source can be the melatonin that extracts in synthetic melatonin, synthetic melatonin analog, the animal hypophysis.
3, according to right 1, Radix Ginseng can be Radix Ginseng Rubra, Radix Ginseng (Radix Ginseng) or Radix Panacis Quinquefolii.
4, according to right 1, contain in the Fructus Alpiniae Oxyphyllae Chinese prescription outside Radix Ginseng, Rhizoma Acori Graminei, Poria, Radix Polygalae, Radix Ophiopogonis, the main component of Semen Ziziphi Spinosae, can also add with in the Radix Polygoni Multiflori, the Radix Astragali, Caulis Polygoni Multiflori, Cortex Acanthopancis, Radix Rehmanniae Preparata, Semen Platycladi, Rhizoma Chuanxiong, Rhizoma Polygonati (processed), Rhizoma Cyperi, Rhizoma Polygonati Odorati, Radix Glycyrrhizae simply, a few flavor or all.
5, according to right 1, the compositions of melatonin and Fructus Alpiniae Oxyphyllae Chinese medicine can be forms such as water preparation, capsule, dropping pill formulation or tablet.
6,, can add the whole, several or a kind of arbitrarily of filler commonly used, disintegrating agent, lubricant, binding agent, coloring agent, fragrant correctives, sweeting agent etc. in the preparation according to right 4.
7, said composition is used for calmness, improves sleep, memory reinforcing etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01141454 CN1408397A (en) | 2001-09-26 | 2001-09-26 | Composition containing melatonin and galangal fruit traditional Chinese medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01141454 CN1408397A (en) | 2001-09-26 | 2001-09-26 | Composition containing melatonin and galangal fruit traditional Chinese medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1408397A true CN1408397A (en) | 2003-04-09 |
Family
ID=4676187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01141454 Pending CN1408397A (en) | 2001-09-26 | 2001-09-26 | Composition containing melatonin and galangal fruit traditional Chinese medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1408397A (en) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005039546A3 (en) * | 2003-10-03 | 2007-10-04 | Veijlen N V | Use of indoleacetic acid derivatives which increase the serum igf-1 level for the preparation of a therapeutical composition for treatment of various diseases |
| CN100360152C (en) * | 2006-02-17 | 2008-01-09 | 南京同仁堂药业有限责任公司 | Medicinal composition for treating insomnia and its preparing process |
| CN100381167C (en) * | 2003-12-31 | 2008-04-16 | 赵恒� | Medicine for treating neurasthenia |
| CN100381165C (en) * | 2003-12-31 | 2008-04-16 | 赵恒� | Medication for improving sleep |
| EP2364157A4 (en) * | 2008-11-03 | 2012-06-13 | Viva Pharmaceutical Inc | Plant extract compositions for affecting sleep |
| CN102526217A (en) * | 2011-10-13 | 2012-07-04 | 宁波海逸生物科技有限公司 | Formula of health-care medicine with functions of strengthening immunity and promoting sleep |
| CN103127382A (en) * | 2013-02-22 | 2013-06-05 | 广西迪泰制药有限公司 | Preparation method of traditional Chinese medicine preparation |
| CN103908125A (en) * | 2014-03-04 | 2014-07-09 | 太仓市伟基生物科技有限公司 | Health maintenance pillow for preventing senile dementia |
| US8883233B2 (en) | 2003-10-03 | 2014-11-11 | Veijlen N.V. | Animal feed composition |
| CN104474423A (en) * | 2014-11-27 | 2015-04-01 | 桂林瑞丰环保微生物应用研究所 | Preparation for improving memory and preventing senile dementia |
| CN104886574A (en) * | 2015-06-04 | 2015-09-09 | 南京贝杉国际贸易有限公司 | Middle-aged and elderly health-care food for improving sleep and protecting eyesight and preparation method thereof |
| CN105011129A (en) * | 2014-04-29 | 2015-11-04 | 赛珂睿德生物医药科技(上海)有限公司 | Functional food with sleep improving effect |
| CN105411856A (en) * | 2015-12-24 | 2016-03-23 | 山东省化工研究院 | Traditional Chinese medicine dropping pill preparing device and method for preparing sleep helping dropping pills with same |
| CN107223680A (en) * | 2017-06-29 | 2017-10-03 | 李永跃 | A kind of schizophyllum commune spina date seed health-caring biscuit and its manufacture craft |
| CN107823428A (en) * | 2017-11-06 | 2018-03-23 | 贵州拜特制药有限公司 | Application of the plain preparation of brain spirit in anti-curing oncoma and its complication medicine is prepared |
| CN108671140A (en) * | 2018-07-05 | 2018-10-19 | 天津益倍元天然产物技术有限公司 | It is a kind of to improve the composition slept and its application |
| CN116549543A (en) * | 2023-06-12 | 2023-08-08 | 云南润苍生科技有限公司 | Compound antioxidant product containing American ginseng and preparation method and application thereof |
-
2001
- 2001-09-26 CN CN 01141454 patent/CN1408397A/en active Pending
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005039546A3 (en) * | 2003-10-03 | 2007-10-04 | Veijlen N V | Use of indoleacetic acid derivatives which increase the serum igf-1 level for the preparation of a therapeutical composition for treatment of various diseases |
| US9408405B2 (en) | 2003-10-03 | 2016-08-09 | Veijlen N.V. | Use of compounds that are able to increase the serum IGF-1 level for the preparation of a therapeutical composition for treatment of various disease states associated with a reduced IGF-1 serum level in humans and animals |
| US10716778B2 (en) | 2003-10-03 | 2020-07-21 | Veijlen | Use of compounds that are able to increase the serum IGF-1 level for the preparation of a therapeutical composition for treatment of various disease states associated with a reduced IGF-1 serum level in humans and animals |
| US8883233B2 (en) | 2003-10-03 | 2014-11-11 | Veijlen N.V. | Animal feed composition |
| CN100381167C (en) * | 2003-12-31 | 2008-04-16 | 赵恒� | Medicine for treating neurasthenia |
| CN100381165C (en) * | 2003-12-31 | 2008-04-16 | 赵恒� | Medication for improving sleep |
| CN100360152C (en) * | 2006-02-17 | 2008-01-09 | 南京同仁堂药业有限责任公司 | Medicinal composition for treating insomnia and its preparing process |
| EP2364157A4 (en) * | 2008-11-03 | 2012-06-13 | Viva Pharmaceutical Inc | Plant extract compositions for affecting sleep |
| CN102526217A (en) * | 2011-10-13 | 2012-07-04 | 宁波海逸生物科技有限公司 | Formula of health-care medicine with functions of strengthening immunity and promoting sleep |
| CN103127382A (en) * | 2013-02-22 | 2013-06-05 | 广西迪泰制药有限公司 | Preparation method of traditional Chinese medicine preparation |
| CN103908125B (en) * | 2014-03-04 | 2015-09-30 | 太仓市伟基生物科技有限公司 | A kind of Health pillow preventing senile dementia |
| CN103908125A (en) * | 2014-03-04 | 2014-07-09 | 太仓市伟基生物科技有限公司 | Health maintenance pillow for preventing senile dementia |
| CN105011129A (en) * | 2014-04-29 | 2015-11-04 | 赛珂睿德生物医药科技(上海)有限公司 | Functional food with sleep improving effect |
| CN104474423A (en) * | 2014-11-27 | 2015-04-01 | 桂林瑞丰环保微生物应用研究所 | Preparation for improving memory and preventing senile dementia |
| CN104886574A (en) * | 2015-06-04 | 2015-09-09 | 南京贝杉国际贸易有限公司 | Middle-aged and elderly health-care food for improving sleep and protecting eyesight and preparation method thereof |
| CN104886574B (en) * | 2015-06-04 | 2017-06-13 | 南京贝杉国际贸易有限公司 | A kind of middle-aged and old health food for improving the health care of sleep protection eyesight and preparation method thereof |
| CN105411856A (en) * | 2015-12-24 | 2016-03-23 | 山东省化工研究院 | Traditional Chinese medicine dropping pill preparing device and method for preparing sleep helping dropping pills with same |
| CN107223680A (en) * | 2017-06-29 | 2017-10-03 | 李永跃 | A kind of schizophyllum commune spina date seed health-caring biscuit and its manufacture craft |
| CN107823428A (en) * | 2017-11-06 | 2018-03-23 | 贵州拜特制药有限公司 | Application of the plain preparation of brain spirit in anti-curing oncoma and its complication medicine is prepared |
| CN108671140A (en) * | 2018-07-05 | 2018-10-19 | 天津益倍元天然产物技术有限公司 | It is a kind of to improve the composition slept and its application |
| CN116549543A (en) * | 2023-06-12 | 2023-08-08 | 云南润苍生科技有限公司 | Compound antioxidant product containing American ginseng and preparation method and application thereof |
| CN116549543B (en) * | 2023-06-12 | 2024-04-12 | 云南润苍生科技有限公司 | Compound antioxidant product containing American ginseng and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1245187C (en) | Medicine for treating eye disease caused by visceral disease | |
| CN1408397A (en) | Composition containing melatonin and galangal fruit traditional Chinese medicine | |
| CN102526474B (en) | Chinese medicine composition for treating neurasthenia | |
| CN104398986A (en) | Tranquilization and brain tonifying epimedium herb oral liquid and preparation method thereof | |
| CN107126485A (en) | It is a kind of to aid in improving Chinese medicine composition of sleep and its preparation method and application | |
| CN102293927B (en) | Compound Chinese medicinal preparation with antifatigue and antioxidation effects, and preparation method thereof | |
| CN103719493B (en) | Siberian solomonseal rhizome health-care tea of a kind of brain-nourishing intelligence-benefiting and preparation method thereof | |
| CN107853517B (en) | Traditional Chinese medicine beverage capable of refreshing and resisting fatigue and preparation method thereof | |
| CN104223068B (en) | A kind of Semen Astragali Complanati oral liquid of the liver and the kidney tonifying improving eyesight and preparation method thereof | |
| CN103749821B (en) | A kind of gynostemma pentaphylla health-care tea improving immunity and preparation method thereof | |
| CN102988905B (en) | Traditional Chinese medicine preparation for treating epilepsia and preparation method thereof | |
| CN104225417A (en) | Traditional Chinese medicine composition with function of assisting improvement of memory and preparation method thereof | |
| CN106728261A (en) | A kind of pharmaceutical composition for treating insomnia | |
| CN108355088A (en) | A kind of spina date seed medicinal liquor and preparation method thereof improving sleep quality | |
| CN102698077A (en) | Traditional Chinese medicine composition for treating sub-health | |
| CN104940844A (en) | Traditional Chinese medicine preparation for treating liver-fire flaming type palpitation and insomnia and preparation method thereof | |
| CN105596551A (en) | Traditional Chinese medicine composition having asthenopia relieving function and preparation method thereof | |
| CN102846871B (en) | Chinese herbal preparation for treating liver-fire ascending type supraorbital neuralgia and preparation method thereof | |
| CN112494569B (en) | Traditional Chinese medicine composition for improving immunity and preparation method and application thereof | |
| CN104225425A (en) | Chinese herbal preparation for enhancing immunity, improving sleep and preventing cardio-cerebrovascular disease, and preparation method thereof | |
| CN104397282A (en) | Tranquilization and brain tonifying eleutherococcus senticosus healthare tea and preparation method thereof | |
| CN104815134B (en) | A kind of pair of physiology has the compound Chinese medicinal preparation and its application of multi-function action | |
| CN1332688C (en) | Medication for treating dementia in blood vessel type, and preparation method | |
| CN107875256B (en) | Zhuang-medicine acupoint application plaster for treating insomnia and manufacturing method thereof | |
| CN1323598A (en) | Antifatigue capsule |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |