CN106177166A - A kind of compositions with function of physical fatigue alleviation and preparation method thereof - Google Patents
A kind of compositions with function of physical fatigue alleviation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of compositions with function of physical fatigue alleviation and preparation method thereof.Said composition is to be prepared from according to a certain weight ratio by Radix Ginseng, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, and it can be made into any common dosage forms, preferred oral preparation.The present composition has function of relieving physical fatigue.
Description
Technical field
The present invention relates to a kind of compositions with function of physical fatigue alleviation and preparation method thereof, belong to the technical field of health food.
Background technology
Fatigue is the physiological acoustic signals process of body load.The definition of tired concept is by the 5th international movement biochemistry meeting of nineteen eighty-two: " its technical ability can not be continued to maintain its predetermined exercise intensity at a specified level or each organ by organism physiology process.”
Modern medicine thinks that fatigue is that body crosses use (transfiniting) and the function that causes reduces and the state of discomfort occurs, mainly shows as tired sleepy, may occur in which degradation simultaneous phenomenon under dizziness, forgetful, sleep quality.The factor relations such as tired generation and energy substance consumption, metabolite accumulation, homeostasis sexual maladjustment, free radical impact are close.Cause reason generally speaking can be summarized as: 1. energy substance consumes excessively, as ATP, CP, muscle glycogen and hepatic glycogen consume excessively；2. fatigue substances is piled up in vivo, and lactic acid and protein breakdown products remain in internal in a large number；The disorder of interior environment, in addition to lactic acid is piled up, changes in environmental conditions in body osmotic pressure, ion distribution, pH, moisture, temperature etc., make body acid-base balance, Osmotic balance, water balance lack of proper care, cause ability to work to decline and fatigue occurs；4. nervous system, enzyme, hormone are to metabolic regulation imbalance during motion etc..
" tired " belongs to the categories such as the traditional Chinese medical science " empty ", " asthenia ", " deficient ", in Huangdi's Internal Classics, and tired many referred to as " tired ", " lassitude and weariness ", " tired thin ", " heavy sensation of the body ", " body weight " etc.." Plain Questions. show a calm opinion piece " in point out " deficiency of the liver, suffer from a deficiency of the kidney insufficiency of the spleen, all make us body weight feeling of restlessness and irritation ", according to the traditional Chinese medical science theory of visceral outward manifestation, tired be all related with the five internal organs, mainly duty in spleen, liver, kidney, also relevant with the heart, lung.Tired generation and gas, blood, the loss of yin, yang have close relationship.It addition, in motor process, Qi, sweating Qi, impairment of body fluid consumption liquid, easily cause YIN-fluid being insufficient, it is seen that fatigue also wasting QI-blood body fluid.In a word, the traditional Chinese medical science is thought tired and is mainly caused spleen, liver, the dirty dysfunction of kidney three by a variety of causes, and the heart, lung are caused by involving negative and positive of qi and blood imbalance.
Along with raising and the enhancing of people's health consciousness of Levels of Social Economic Development, people recognize the importance of alleviating physical fatigue more and more, and the product of alleviating physical fatigue receives the concern of people the most more and more.The mankind re-recognize for health so that the theory of " diseases prevention be better than cure the disease " is rooted in the hearts of the people, and the advantage that health food can be taken with long-term safety with it firmly gets the approval of people.Thus, exploitation has the product of function of physical fatigue alleviation and has wide market prospect.
Summary of the invention
It is an object of the present invention to provide one and there is alleviating physical fatigue, the compositions of kidney invigorating and Yang strengthening function.
Another object of the present invention there is provided the preparation method of said composition.
The present invention is achieved by the following technical solutions:
The present invention is made up of the raw material of following weight parts:
Radix Ginseng 20-80 part, Cortex Cinnamomi 5-45 part, Fructus Lycii 70-130 part, Penis et testis cervi 20-80 part, snow chrysanthemum 45-100 part, Stichopus japonicus 20-80 part.
It is preferably:
Radix Ginseng 40-60 part, Cortex Cinnamomi 15-35 part, Fructus Lycii 90-110 part, Penis et testis cervi 40-60 part, snow chrysanthemum 65-85 part, Stichopus japonicus 40-60 part.
More preferably:
Radix Ginseng 50 parts, Cortex Cinnamomi 25 parts, Fructus Lycii 100 parts, Penis et testis cervi 50 parts, snow chrysanthemum 75 parts, Stichopus japonicus 50 parts.
In the present invention, the mechanism of action of each component is as follows:
Radix Ginseng: for the dry root and rhizome of Araliaceae Radix Ginseng.Property hardship sweet, micro-, flat, return spleen, lung, heart channel.Having strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, the effect calmed the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung breathes with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb；Heart failure, cardiogenic shock.Modern study shows, containing saponins, saccharide, volatile ingredient in Radix Ginseng, and organic acid and ester thereof, several amino acids, protein, enzyme, sterol and glycosides thereof, many peptides, nitrogen-containing compound, lignin, flavonoid, vitamins, inorganic elements etc..There is strengthening by means of tonics, improve muscle power and mental work ability, reduce fatigue, the effect of regulation central nervous system.Radix Ginseng can improve thinking and body activities ability, not only can strengthen neural excitation, also can strengthen its process of inhibition, make suppression tend to concentrating, differentiation so that excitement and two kinds of nervous process of suppression are balanced, improves the intelligence of people and physical labor efficiency completely.It is proved panaxoside Rg1Effect is notable, to old rats lumbar injection 20,40mg/kg panaxoside Rg110d continuously, finds to walk number of times between rat grid and upright number of times substantially increases, result points out it can improve the mobility of older animals decline.Utilizing Radix Ginseng extractive solution to study Endurance, experimental result finds that Radix Ginseng extractive solution can significantly extend the mice burden swimming time, continues swimming time and averagely extends 31.84% than matched group, and persistently swimming maximum duration averagely improves 7.93 min；Swimming time averagely extends 30.64% than matched group, and power exhausts swimming maximum duration and averagely improves 7.27% than matched group.Illustrate that Radix Ginseng can improve endurance and motor capacity, reduce nervus centralis fatigue reaction.
Cortex Cinnamomi: for the dry bark of canella Cortex Cinnamomi.Pungent, sweet, the hottest, return kidney, spleen, the heart, Liver Channel.There is benefit fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, effect of promoting blood circulation to restore menstrual flow, for sexual impotence, cold womb, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.The sweet heat of this product is supporing yang mends fire, for controlling the key medicine of decline of the fire from the gate of life, commonly uses and controls insufficiency of kidney-YANG, the sexual impotence cold womb of decline of the fire from the gate of life, chills and pain of the waist and kness, nocturia, the spermatorrhea enuresis etc..
Fructus Lycii: for plant of Solanaceae lycium barbarumLycium barbarum L. dry mature fruit.Nature and flavor are sweet, flat, return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.Curing mainly asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat quenches one's thirst, and blood deficiency and yellow complexion, blurred vision is not clear waits disease.Modern pharmacology research confirms that Fructus Lycii has regulation immunity of organism, anti-fatigue effect, it addition, Fructus Lycii can also effectively suppress tumor growth and cell mutation, have the effect of the aspects such as slow down aging.The mechanism of Fructus Lycii resisting fatigue is: Fructus Lycii can dramatically increase the stockage of muscle glycogen, hepatic glycogen, improves human activity, and has the effect of resisting fatigue.
Penis et testis cervi: for the external genitalia that animal in deer family Cervus nippon Temminck or Cervus elaphus linnaeus are male.Sweet in the mouth, salty, warm in nature, return liver, kidney, bladder warp.The kidney invigorating essence, invigorating kidney-YANG, benefit essence, strong waist knee joint.Curing mainly strain of suffering from a deficiency of the kidney, soreness of waist and knee joint, deafness and tinnitus, sexual impotence, seminal emission, premature ejaculation, cold womb is infertile, and leukorrhagia is the dilutest.Penis et testis cervi is containing protein, fat, font steroid hormone, vitamin C, A and inorganic calcium, phosphorus, ferrum etc., there is kidney-replenishing, the merit of benefiting essence-blood, is used for straining, soreness of waist and knee joint tinnitus due to deficiency of the kidney, sexual impotence, infertility, sexual dysfunction etc., and the crowd of being suitable for includes: 1. need the man of the kidney invigorating.2. have a delicate constitution, easy tired, the man of sore waist and aching in the waist and the back.The most sterile person etc..
Snow chrysanthemum: bitter in the mouth, pungent, cold nature, returns lung, Liver Channel.Snow chrysanthemum includes more than 30 kind of Flavonoid substances, the mineral element of more than 30 kind of needed by human, 20 several amino acids, tens of kinds of aromatic compounds, also have the organic acid enriched, terpenes, vitamin, lignan, enzyme, polysaccharide etc. to have bioactive natural component.Modern pharmacological research shows, volatile oil in snow chrysanthemum, total saponins, aminoacid, Flavonoid substances, pathogen can be resisted, strengthen capillary resistance, wherein, general flavone content reaches 12%, flavone is the strongest a kind of antioxidant, can the oxygen-derived free radicals in purged body effectively, the ability of this prevention oxidation is more than 10 times of vitamin E, the degeneration of cell can be stoped, aging and the generation of canceration, snow chrysanthemum in rich in these biological general flavones, terpene substances, sulfur-containing compound, it is collectively referred to as the factor having immunoloregulation function, it it is blood pressure lowering, blood fat reducing, regulation blood glucose, the element that antitumor is important with defying age related drugs.
Stichopus japonicus: for Stichopodidae animal Radix Morinae Bulleyanae, Stichopus chloronotus (Brandt)., the entirety of change Radix Morinae Bulleyanae.Cold nature is sweet in the mouth, salty.Return lung, kidney, large intestine channel.Having the kidney invigorating and essence nourishing, blood enriching and dryness moistening, effect of hemostasis, lose for essence and blood, weak labor is timid, sexual impotence, nocturnal emission, dryness of the intestine constipation, and cough due to deficiency of the lung spits blood, discharging fresh blood stool, traumatic hemorrhage etc..Stichopus japonicus contains outside protein, calcium, potassium, zinc, ferrum, selenium, manganese isoreactivity material, and its other active component internal forms Stichopus Japonicus Acidic Mucopolysaccharide by holothurin and by amidohexose, alduronic acid and fucose etc., another containing 18 kinds of aminoacid and without cholesterol.Because Stichopus japonicus is warm in nature, having the kidney invigorating and essence nourishing, the strong sun of YIN nourishing, nourishing blood for moistening dryness, regulating menstruation are dispelled the tonifying both YIN and YANG effect such as labor, fetus nourishing profit product, can improve male endocrine ability, improve the metabolism of women, promote sex hormones secretion ability, improve sexual function.
Therefore, the compositions that the present invention relates to is on the basis of existing theory of Chinese medical science, filter out can the prescription of effectively alleviating physical fatigue, the kidney invigorating and essence nourishing, carry out scientific compatibility, play its mutual synergism, thus obtain a kind of there is kidney invigorating and YANG supporting, alleviate formula tired out, to regain one's strength of body function.
Instant component can use the conventional method of Chinese medicine preparation to be prepared as the preparation of any routine, including oral formulations, external preparation, injection etc..These crude drug such as can be ground into powder mix homogeneously；The crude drug of described weight portion can be added water respectively or the ethanol extraction of variable concentrations, extracting solution concentrate drying obtains crude extract, or employing process for purification, such as, decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation carry out being refining to obtain extract.
When using said medicine, both can use and clean respectively for raw material with the medicine being equivalent to described weight proportion, and be dried, pulverize, be mixed to get and meet the granule of formulation requirements granularity or powder is directly taken.Can also use and after suitably processing, add pharmaceutic adjuvant with the medicine being equivalent to described weight proportion relation for raw material, be made into various preparation as required.During being prepared as preparation by above-mentioned raw materials medicine, above-mentioned raw materials medicine can be adopted and process with the following method: the crude drug of described weight portion is directly pulverized to obtain medicinal powder；Or add water respectively or the ethanol extraction of variable concentrations or use decoction and alcohol sedimentation technique, centrifuging, extraction by steam distillation to obtain extract；Adoptable concrete operations and/or using method when above-mentioned effective medicinal ingredient is extracted, both can be with the ingredient of described each proportional quantities as raw material, extract decomposite mode after its effective medicinal ingredient respectively, it would however also be possible to employ the mode of common extraction again after mixing by each medicine material of described proportional quantities.The actual conditionses such as ideal required when using different extraction means, equipment and extract or optimal Extracting temperature, solvent load, extraction time, extraction time, then can be screened by test according to practical situation and find.
A kind of method of any of the above all can prepare the active component of the present composition, and this active component can directly be used as medicine and take or add acceptable adjuvant on pharmaceutics required preparation is produced in conventional fashion into.As the oral drugs of the solid dosage form such as conventional tablet (dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, effervescent tablet), capsule (hard capsule, soft capsule), granule, pill (drop pill), powder can be made, it is also possible to make the oral drugs of the liquid forms such as syrup, medicated wine, tincture, oral liquid.Therefore, in said composition in addition to effective ingredient, it is also possible to containing pharmaceutically acceptable adjuvant.
Adjuvant described here, can be different according to different preparations, such as diluent conventional in the solid preparations such as tablet, capsule, granule, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler etc.；Surfactant conventional in the liquid forms such as syrup, oral liquid, diluent, preservative, stabilizer, correctives, thickening agent, fluidizer etc..
nullIts conventional adjuvant such as starch、Lactose、Sucrose、Dextrin、Icing Sugar、Microcrystalline Cellulose、Mannitol、Xylitol、Polyethylene Glycol、Calcium sulfate、Calcium hydrogen phosphate、Calcium carbonate、Modified starch、Sorbitol、Erythritol、Polyvinylpyrrolidone、Heavy Magnesium Carbonate、Sodium carboxymethyl cellulose、Hydroxypropyl methylcellulose、Methylcellulose、Ethyl cellulose、Carboxymethylstach sodium、Hydroxypropyl cellulose、PVP K30、Kaolin、Pregelatinized Starch、Magnesium stearate、Pulvis Talci、Micropowder silica gel、Stevioside、Glycine betaine、Aspartame、Glycyrrhizin、Saccharin sodium、Crystal sugar、Mel、Citric acid、Sodium bicarbonate、Sodium carbonate、Carrageenan、Agar、Gelatin、Sodium alginate、Xanthan gum、Guar gum、Tragcanth、Arabic gum、Locust bean gum、Stearic acid、Glyceryl monostearate、Polyacrylamide、Cross linked sodium polyacrylate、Polyvinyl alcohol、Carbomer、Sorbic acid、Potassium sorbate、Ethyl hydroxybenzoate、Benzyl alcohol、Nipalgin、Thimerosal、Dimethyl sulfoxide、Azone、Triethanolamine、Sodium hydroxide、Glycerol、Propylene glycol、BHT、BHA、Sodium lauryl sulphate、Tweens、Spans etc..
Take following preparation method to make each component of said composition can preferably play drug effect, the preferably component to weight of the present invention, but cannot be used for limiting the scope of the invention.
The preparation of present composition medicated wine uses extraction process or percolation technique, specific as follows:
Extraction process: take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, broken, add 4-20 times amount 20-95% ethanol extraction, extracting solution filters, and adds appropriate amount of auxiliary materials, mixing, adjusts alcoholic strength, allocates to full dose, stands, filters, to obtain final product.
Or:
Extraction process: take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, broken, add 4-20 times amount water extraction, extracting solution filters, and adds appropriate amount of auxiliary materials, mixing, adjusts alcoholic strength, allocates to full dose, stands, filters, to obtain final product.
Or:
Percolation technique: take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, adds appropriate 20-95% ethanol and infiltrates 1-3 hour, loads and adds 20-95% alcohol dipping 12-48 hour in percolate pot, percolation, collect percolate, filter, add appropriate amount of auxiliary materials, mixing, adjust alcoholic strength, allocate to full dose, stand, filter, to obtain final product.
The preparation of present composition medicated wine is preferably:
Extraction process: take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, it is crushed to coarse powder, adding 6-12 times amount 20-95% ethanol extraction, extracting solution filters, and adds appropriate amount of auxiliary materials, mixing, adjustment alcoholic strength, to 25 °-80 °, is allocated to full dose, stands 3-6 month, filter, to obtain final product.
Or:
Extraction process: take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, broken, add 6-12 times amount water reflux, extract, 1-4 time, each 1-3 hour, extracting solution filters, add appropriate amount of auxiliary materials, mixing, adjust alcoholic strength to 25 °-80 °, allotment is to full dose, stand, filter, to obtain final product.
Or:
Percolation technique: take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, adds appropriate 20-95% ethanol and infiltrates 2 hours, load in percolate pot and add 20-95% alcohol dipping 24 hours, percolation, collect percolate, filter, add appropriate amount of auxiliary materials, mixing, adjustment alcoholic strength, to 25 °-80 °, is allocated to full dose, stands 3-6 month, filter, to obtain final product.
Wherein, one or more during adjuvant refers to crystal sugar, sucrose, Mel；It is preferably crystal sugar.
Alcoholic strength preferably adjusts to 35 °-55 °.
The preparation method of present composition solid preparation is:
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add water or the ethanol extraction of variable concentrations, extracting solution merges, and filters, and filtrate decompression dry, pulverize into fine powder, is not added with or adds appropriate amount of auxiliary materials, is prepared as Conventional solid preparation.
Or:
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Penis et testis cervi are ground into fine powder, and Fructus Lycii, snow chrysanthemum, Stichopus japonicus add water or the ethanol extraction of variable concentrations, and extracting solution merges, filtering, filtrate decompression dry, pulverize into fine powder, mix with above-mentioned fine powder, be not added with or add appropriate amount of auxiliary materials, be prepared as Conventional solid preparation.
Or:
The Radix Ginseng taking described weight portion is divided into two parts, a portion is ground into fine powder, remainder people participates in Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus add water or the ethanol extraction of variable concentrations, extracting solution merges, and filters, and filtrate decompression is dried, it is ground into fine powder, mix with above-mentioned fine powder, be not added with or add appropriate amount of auxiliary materials, be prepared as Conventional solid preparation.
Wherein, the preparation method of present composition tablet can be:
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add water or the ethanol extraction of variable concentrations, extracting solution merges, filtering, filtrate decompression dry, pulverize into fine powder, add appropriate filler, disintegrating agent, correctives, mixing, pelletize, it is dried, add magnesium stearate, mixing, tabletting, coating or not coating, obtain tablet.
The preparation method of present composition granule can be:
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add water or the ethanol extraction of variable concentrations, extracting solution merges, and filters, filtrate decompression dry, pulverize into fine powder, adds appropriate amount of auxiliary materials, mixing, alcohol granulation, is dried, granulate, obtains granule.
The preparation method of present composition pill can be:
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Penis et testis cervi are ground into fine powder, and Fructus Lycii, snow chrysanthemum, Stichopus japonicus add water or the ethanol extraction of variable concentrations, and extracting solution merges, filtering, filtrate decompression dry, pulverize into fine powder, mix with above-mentioned fine powder, add appropriate amount of auxiliary materials, make pill according to a conventional method.
Only obtained through refining to the present invention method of above-mentioned preparation method is enumerated, but this should not being interpreted as, preparation method of the present invention is only limited to above-mentioned cited method.
The detailed description of the invention of form by the following examples, is described in further detail the foregoing of the present invention.But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to below example.All technology realized based on foregoing of the present invention belong to the scope of the present invention.
Detailed description of the invention
Embodiment 1
Radix Ginseng 50g, Cortex Cinnamomi 25g, Fructus Lycii 100g, Penis et testis cervi 50g, snow chrysanthemum 75g, Stichopus japonicus 50g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, be crushed to coarse powder, add 6 times amount 60% ethanol extractions, extracting solution filters, add appropriate crystal sugar, mixing, adjustment alcoholic strength is to 50 °, and allotment is to full dose, stand 3-6 month, filter, to obtain final product.
Embodiment 2
Radix Ginseng 50g, Cortex Cinnamomi 25g, Fructus Lycii 100g, Penis et testis cervi 50g, snow chrysanthemum 75g, Stichopus japonicus 50g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, be crushed to coarse powder, add 12 times amount 40% ethanol extractions, extracting solution filters, add appropriate crystal sugar, mixing, adjustment alcoholic strength is to 38 °, and allotment is to full dose, stand 3-6 month, filter, to obtain final product.
Embodiment 3
Radix Ginseng 40g, Cortex Cinnamomi 35g, Fructus Lycii 90g, Penis et testis cervi 60g, snow chrysanthemum 65g, Stichopus japonicus 60g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, be crushed to coarse powder, add 10 times amount 50% ethanol extractions, extracting solution filters, add appropriate crystal sugar, mixing, adjustment alcoholic strength is to 35 °, and allotment is to full dose, stand 3-6 month, filter, to obtain final product.
Embodiment 4
Radix Ginseng 60g, Cortex Cinnamomi 15g, Fructus Lycii 110g, Penis et testis cervi 40g, snow chrysanthemum 85g, Stichopus japonicus 40g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, be crushed to coarse powder, add 8 times amount 30% ethanol extractions, extracting solution filters, add appropriate crystal sugar, mixing, adjustment alcoholic strength is to 55 °, and allotment is to full dose, stand 3-6 month, filter, to obtain final product.
Embodiment 5
Radix Ginseng 20g, Cortex Cinnamomi 45g, Fructus Lycii 70g, Penis et testis cervi 80g, snow chrysanthemum 45g, Stichopus japonicus 80g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, be crushed to coarse powder, add 15 times amount 20% ethanol extractions, extracting solution filters, add appropriate crystal sugar, mixing, adjustment alcoholic strength is to 25 °, and allotment is to full dose, stand 3-6 month, filter, to obtain final product.
Embodiment 6
Radix Ginseng 80g, Cortex Cinnamomi 5g, Fructus Lycii 130g, Penis et testis cervi 20g, snow chrysanthemum 100g, Stichopus japonicus 20g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, be crushed to coarse powder, add 20 times amount 30% ethanol extractions, extracting solution filters, add appropriate crystal sugar, mixing, adjustment alcoholic strength is to 80 °, and allotment is to full dose, stand 3-6 month, filter, to obtain final product.
Embodiment 7
Radix Ginseng 55g, Cortex Cinnamomi 20g, Fructus Lycii 105g, Penis et testis cervi 45g, snow chrysanthemum 70g, Stichopus japonicus 55g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, be crushed to coarse powder, add 4 times amount 95% ethanol extractions, extracting solution filters, adding proper honey, crystal sugar, mixing, adjustment alcoholic strength is to 60 °, and allotment is to full dose, stand 3-6 month, filter, to obtain final product.
Embodiment 8
Radix Ginseng 45g, Cortex Cinnamomi 30g, Fructus Lycii 115g, Penis et testis cervi 55g, snow chrysanthemum 80g, Stichopus japonicus 45g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, be crushed to coarse powder, add 16 times amount 50% ethanol extractions, extracting solution filters, adding suitable amount of sucrose, mixing, adjustment alcoholic strength is to 40 °, and allotment is to full dose, stand 3-6 month, filter, to obtain final product.
Embodiment 9
Radix Ginseng 50g, Cortex Cinnamomi 25g, Fructus Lycii 100g, Penis et testis cervi 50g, snow chrysanthemum 75g, Stichopus japonicus 50g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add appropriate 60% ethanol and infiltrate 2 hours, load in percolate pot and add 60% alcohol dipping 24 hours, percolation, collect percolate, filter, add appropriate crystal sugar, mixing, adjustment alcoholic strength, to 50 °, is allocated to full dose, stands 3-6 month, filter, to obtain final product.
Embodiment 10
Radix Ginseng 50g, Cortex Cinnamomi 25g, Fructus Lycii 100g, Penis et testis cervi 50g, snow chrysanthemum 75g, Stichopus japonicus 50g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add appropriate 40% ethanol and infiltrate 2 hours, load in percolate pot and add 40% alcohol dipping 24 hours, percolation, collect percolate, filter, add appropriate crystal sugar, mixing, adjustment alcoholic strength, to 38 °, is allocated to full dose, stands 3-6 month, filter, to obtain final product.
Embodiment 11
Radix Ginseng 40g, Cortex Cinnamomi 35g, Fructus Lycii 90g, Penis et testis cervi 60g, snow chrysanthemum 65g, Stichopus japonicus 60g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add appropriate 20% ethanol and infiltrate 3 hours, load in percolate pot and add 20% alcohol dipping 12 hours, percolation, collect percolate, filter, add appropriate crystal sugar, mixing, adjustment alcoholic strength, to 35 °, is allocated to full dose, stands 3-6 month, filter, to obtain final product.
Embodiment 12
Radix Ginseng 60g, Cortex Cinnamomi 15g, Fructus Lycii 95g, Penis et testis cervi 40g, snow chrysanthemum 85g, Stichopus japonicus 40g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add appropriate 95% ethanol and infiltrate 1 hour, load in percolate pot and add 95% alcohol dipping 48 hours, percolation, collect percolate, filter, add appropriate crystal sugar, mixing, adjustment alcoholic strength, to 55 °, is allocated to full dose, stands 3-6 month, filter, to obtain final product.
Embodiment 13
Radix Ginseng 20g, Cortex Cinnamomi 45g, Fructus Lycii 75g, Penis et testis cervi 80g, snow chrysanthemum 45g, Stichopus japonicus 80g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add appropriate 50% ethanol and infiltrate 2 hours, load in percolate pot and add 50% alcohol dipping 24 hours, percolation, collect percolate, filter, add proper honey, mixing, adjustment alcoholic strength, to 80 °, is allocated to full dose, stands 3-6 month, filter, to obtain final product.
Embodiment 14
Radix Ginseng 80g, Cortex Cinnamomi 10g, Fructus Lycii 135g, Penis et testis cervi 20g, snow chrysanthemum 100g, Stichopus japonicus 20g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add appropriate 30% ethanol and infiltrate 3 hours, load in percolate pot and add 30% alcohol dipping 24 hours, percolation, collect percolate, filter, add suitable amount of sucrose, crystal sugar, mixing, adjustment alcoholic strength, to 30 °, is allocated to full dose, stands 3-6 month, filter, to obtain final product.
Embodiment 15
Radix Ginseng 60g, Cortex Cinnamomi 25g, Fructus Lycii 120g, Penis et testis cervi 45g, snow chrysanthemum 70g, Stichopus japonicus 55g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add appropriate 80% ethanol and infiltrate 1 hour, load in percolate pot and add 80% alcohol dipping 12 hours, percolation, collect percolate, filter, add suitable amount of sucrose, mixing, adjustment alcoholic strength, to 25 °, is allocated to full dose, stands 3-6 month, filter, to obtain final product.
Embodiment 16
Radix Ginseng 40g, Cortex Cinnamomi 30g, Fructus Lycii 115g, Penis et testis cervi 55g, snow chrysanthemum 80g, Stichopus japonicus 45g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add 10 times amount water extraction 3 times, each 2 hours, extracting solution merges, and filters, and filtrate decompression is dried, it is ground into fine powder, adds appropriate carboxymethyl starch sodium, micropowder silica gel, microcrystalline Cellulose, polyvinylpolypyrrolidone, xylitol, be sufficiently mixed, alcohol granulation, is dried, granulate, add appropriate magnesium stearate, mixing, tabletting, film coating, obtains tablet.
Embodiment 17
Radix Ginseng 70g, Cortex Cinnamomi 20g, Fructus Lycii 80g, Penis et testis cervi 70g, snow chrysanthemum 90g, Stichopus japonicus 25g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add 10 times amount 60% ethanol extraction 3 times, each 2 hours, extracting solution merged, filter, reclaim ethanol, filtrate reduced in volume, dry, pulverize into fine powder, add appropriate mannitol, lactose, dextrin, aspartame, it is sufficiently mixed, alcohol granulation, is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, film coating, obtain tablet.
Embodiment 18
Radix Ginseng 25g, Cortex Cinnamomi 40g, Fructus Lycii 75g, Penis et testis cervi 25g, snow chrysanthemum 50g, Stichopus japonicus 70g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add 10 times amount water extraction 3 times, each 2 hours, extracting solution merged, and filtered, filtrate decompression dry, pulverize into fine powder, adds lactose, mannitol in right amount, mixing, alcohol granulation, is dried, granulate, obtains granule.
Embodiment 19
Radix Ginseng 35g, Cortex Cinnamomi 30g, Fructus Lycii 85g, Penis et testis cervi 55g, snow chrysanthemum 60g, Stichopus japonicus 50g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add 8 times amount 70% ethanol extraction 2 times, each 2 hours, extracting solution merges, and filters, and reclaims ethanol, filtrate reduced in volume, dry, pulverize into fine powder, adding sucrose, aspartame, dextrin is appropriate, mixing, alcohol granulation, it is dried, granulate, obtains granule.
Embodiment 20
Radix Ginseng 50g, Cortex Cinnamomi 30g, Fructus Lycii 100g, Penis et testis cervi 45g, snow chrysanthemum 70g, Stichopus japonicus 50g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add 12 times amount water extraction 3 times, each 1 hour, extracting solution merged, and filtered, filtrate decompression dry, pulverize into fine powder, adds appropriate amount of auxiliary materials, mixing, pelletize, be dried, encapsulated, obtain capsule.
Embodiment 21
Radix Ginseng 25g, Cortex Cinnamomi 40g, Fructus Lycii 75g, Penis et testis cervi 75g, snow chrysanthemum 50g, Stichopus japonicus 75g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add 8 times amount 50% ethanol extraction 2 times, each 2 hours, extracting solution merged, filter, reclaim ethanol, filtrate reduced in volume, be dried, it is ground into fine powder, adds appropriate amount of auxiliary materials, mixing, make pill.
Embodiment 22
Radix Ginseng 75g, Cortex Cinnamomi 10g, Fructus Lycii 125g, Penis et testis cervi 25g, snow chrysanthemum 95g, Stichopus japonicus 25g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add 12 times amount 95% ethanol extraction 3 times, each 1.5 hours, extracting solution merged, and filtered, and reclaims ethanol, filtrate reduced in volume, dry, pulverize into fine powder, make powder.
Embodiment 23
Radix Ginseng 50g, Cortex Cinnamomi 25g, Fructus Lycii 100g, Penis et testis cervi 40g, snow chrysanthemum 70g, Stichopus japonicus 10g
Taking the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add 6 times amount 70% ethanol extraction 1 time, extract 3 hours, extracting solution merges, and filters, and reclaims ethanol, filtrate reduced in volume, makes tincture according to common process.
Embodiment 24
Radix Ginseng 60g, Cortex Cinnamomi 25g, Fructus Lycii 120g, Penis et testis cervi 45g, snow chrysanthemum 70g, Stichopus japonicus 55g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add appropriate 70% ethanol and infiltrate 1 hour, load in percolate pot and add 70% alcohol dipping 12 hours, percolation, collect percolate, filter, add suitable amount of sucrose, mixing, adjustment alcoholic strength, to 70 °, is allocated to full dose, stands 3-6 month, filter, to obtain final product.
Embodiment 25
Radix Ginseng 40g, Cortex Cinnamomi 30g, Fructus Lycii 115g, Penis et testis cervi 55g, snow chrysanthemum 80g, Stichopus japonicus 45g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Penis et testis cervi are ground into fine powder, and Fructus Lycii, snow chrysanthemum, Stichopus japonicus add 10 times amount water extraction 4 times, each 1 hour, extracting solution merges, and filters, and filtrate decompression is dried, it is ground into fine powder, mixes with above-mentioned fine powder, add appropriate carboxymethyl starch sodium, micropowder silica gel, microcrystalline Cellulose, polyvinylpolypyrrolidone, xylitol, it is sufficiently mixed, alcohol granulation, is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, film coating, obtain tablet.
Embodiment 26
Radix Ginseng 70g, Cortex Cinnamomi 20g, Fructus Lycii 80g, Penis et testis cervi 70g, snow chrysanthemum 90g, Stichopus japonicus 25g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Penis et testis cervi are ground into fine powder, and Fructus Lycii, snow chrysanthemum, Stichopus japonicus add 10 times amount 60% ethanol extraction 2 times, and each 2 hours, extracting solution merged, filter, reclaim ethanol, filtrate reduced in volume, be dried, it is ground into fine powder, mixes with above-mentioned fine powder, add appropriate mannitol, lactose, dextrin, aspartame, it is sufficiently mixed, alcohol granulation, is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, film coating, obtain tablet.
Embodiment 27
Radix Ginseng 25g, Cortex Cinnamomi 40g, Fructus Lycii 75g, Penis et testis cervi 25g, snow chrysanthemum 50g, Stichopus japonicus 70g
The Radix Ginseng powder taking described weight portion 3/4 is broken into fine powder, and remainder people participates in Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus add 10 times amount water extraction 2 times, each 2 hours, extracting solution merges, and filters, and filtrate decompression is dried, it is ground into fine powder, mix with above-mentioned fine powder, add lactose, mannitol in right amount, mixing, alcohol granulation, it is dried, granulate, obtains granule.
Embodiment 28
Radix Ginseng 35g, Cortex Cinnamomi 30g, Fructus Lycii 85g, Penis et testis cervi 55g, snow chrysanthemum 60g, Stichopus japonicus 50g
The Radix Ginseng powder taking described weight portion 1/4 is broken into fine powder, and remainder people participates in Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus add 8 times amount 70% ethanol extraction 2 times, each 2 hours, extracting solution merges, and filters, and reclaims ethanol, filtrate reduced in volume, dry, pulverize into fine powder, adding sucrose, aspartame, dextrin is appropriate, mixing, alcohol granulation, it is dried, granulate, obtains granule.
Embodiment 29
Radix Ginseng 50g, Cortex Cinnamomi 25g, Fructus Lycii 100g, Penis et testis cervi 50g, snow chrysanthemum 75g, Stichopus japonicus 50g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Penis et testis cervi are ground into fine powder, and Fructus Lycii, snow chrysanthemum, Stichopus japonicus add 10 times amount water extraction 4 times, and each 1 hour, extracting solution merged, filtering, filtrate decompression dry, pulverize into fine powder, mix with above-mentioned fine powder, add appropriate amount of auxiliary materials, make pill according to a conventional method.
Embodiment 30
Radix Ginseng 70g, Cortex Cinnamomi 20g, Fructus Lycii 80g, Penis et testis cervi 70g, snow chrysanthemum 90g, Stichopus japonicus 25g
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Penis et testis cervi are ground into fine powder, Fructus Lycii, snow chrysanthemum, Stichopus japonicus add 10 times amount 60% ethanol extraction 2 times, and each 2 hours, extracting solution merged, filter, reclaim ethanol, filtrate reduced in volume, be dried, it is ground into fine powder, mix with above-mentioned fine powder, add appropriate amount of auxiliary materials, make pill according to a conventional method.
According to foregoing, without departing under basic fundamental thought premise of the present invention, according to ordinary technical knowledge and the customary means of this area, it is clear that the amendment of other various ways can also be made, replace and change.
The beneficial effect of of the present invention compositions be expanded on further by following experiment:
1, test material
Test group: prepared by the embodiment of the present invention 1；Matched group: placebo.
2, experimental animal
Adult mice, body weight 18-22g, male and female half and half.
3, test apparatus
Swimming trunk (50cm × 50cm × 40cm), electronic balance, sheet lead.
4, test method
Mice is randomly divided into 2 groups, i.e. test group and matched group, often group 10, sub-cage rearing, free diet, room temperature (28 ± 2 DEG C), relative humidity 45%-48%, timing every night gavage, every day 1 time, continuous gavage 30 days.After last gavage, the mice of root of the tail portion load 5% body weight sheet lead is placed in swimming trunk went swimming.The depth of water is no less than 30cm, water temperature 25 DEG C ± 1.0 DEG C, and mice starts to dead time, i.e. mice burden swimming time record from swimming.
5, result of the test
The walking weight load of test group mice compares with matched group, and difference has significance (P ＜ 0.05), is specifically shown in Table 1.
Table
1
The mice burden swimming time
*: compare with matched group, difference has significance, P ＜ 0.05.
Embodiment of the present invention 2-30 has carried out similar test the most according to the method described above, and result is identical with the above results.
6, conclusion
After the mouse stomach present composition, comparing with blank group, walking weight load is obviously prolonged, and difference has significance (P ＜ 0.05).The prompting present composition has significant function of relieving physical fatigue.
Claims (10)
1. a compositions with function of physical fatigue alleviation, it is characterised in that it is made up of the component of following weight portion: Radix Ginseng 20-80 part, Cortex Cinnamomi 5-45 part, Fructus Lycii 70-130 part, Penis et testis cervi 20-80 part, snow chrysanthemum 45-100 part, Stichopus japonicus 20-80 part.
Compositions the most according to claim 1, it is characterised in that it is made up of the component of following weight portion: Radix Ginseng 40-60 part, Cortex Cinnamomi 15-35 part, Fructus Lycii 90-110 part, Penis et testis cervi 40-60 part, snow chrysanthemum 65-85 part, Stichopus japonicus 40-60 part.
3. the preparation method of compositions described in claim 1 or 2, it is characterised in that it is prepared:
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus directly pulverize to obtain medicinal powder；Or add water or the ethanol extraction of variable concentrations, extracting solution concentrate drying obtains crude extract；Or use further decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation one or more be used in combination suitably refine after extract；Above-mentioned medicinal powder or crude extract or extract are not added with or add appropriate amount of auxiliary materials, and technique makes the preparation accepted on pharmaceutics routinely.
Preparation method the most according to claim 3, it is characterised in that described preparation refers to tablet, granule, capsule, pill, powder, tincture, medicated wine.
Preparation method the most according to claim 4, it is characterised in that described preparation refers to medicated wine.
Preparation method the most according to claim 5, it is characterised in that medicated wine is prepared:
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, broken, add 4-20 times amount 20-95% ethanol extraction, extracting solution filters, and adds appropriate amount of auxiliary materials, mixing, adjusts alcoholic strength, allocates to full dose, stands, filters, to obtain final product.
Preparation method the most according to claim 4, it is characterised in that medicated wine is prepared:
Take the Radix Ginseng of described weight portion, Cortex Cinnamomi, Fructus Lycii, Penis et testis cervi, snow chrysanthemum, Stichopus japonicus, add appropriate 20-95% ethanol and infiltrate 1-3 hour, load and percolate pot adds 20-95% alcohol dipping 12-48 hour, percolation, collect percolate, filter, add appropriate amount of auxiliary materials, mixing, adjust alcoholic strength, allocate to full dose, stand, filter, to obtain final product.
8. according to the preparation method described in claim 6 or 7, it is characterised in that described adjuvant refers to one or more in crystal sugar, sucrose, Mel.
Preparation method the most according to claim 8, it is characterised in that described adjuvant refers to crystal sugar.
10. compositions described in claim 1 or 2 is for preparing the application in the food or health food with function of physical fatigue alleviation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108523029A (en) * | 2017-12-15 | 2018-09-14 | 华南理工大学 | A kind of composition with deferring senility containing leaf melon conopsea extraction and its application |
| CN111227244A (en) * | 2020-03-09 | 2020-06-05 | 中科花鹿农业发展有限公司 | Multi-effect penis cervi pill and preparation method thereof |
| CN111304045A (en) * | 2020-03-13 | 2020-06-19 | 中科花鹿农业发展有限公司 | Deer penis wine and preparation method thereof |
-
2015
- 2015-05-06 CN CN201510224834.5A patent/CN106177166A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108523029A (en) * | 2017-12-15 | 2018-09-14 | 华南理工大学 | A kind of composition with deferring senility containing leaf melon conopsea extraction and its application |
| CN111227244A (en) * | 2020-03-09 | 2020-06-05 | 中科花鹿农业发展有限公司 | Multi-effect penis cervi pill and preparation method thereof |
| CN111304045A (en) * | 2020-03-13 | 2020-06-19 | 中科花鹿农业发展有限公司 | Deer penis wine and preparation method thereof |
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Application publication date: 20161207 |