A kind of compound Chinese medicinal preparation and application thereof physiology being had to multi-function action
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation and the application thereof that physiology are had to multi-function action (there is kidney invigorating and YANG supporting, the treatment of sexual dysfunction, slow down aging), described compound Chinese medicinal preparation is that crude drug is prepared from following Chinese medicine: Cornu Cervi Pantotrichum, Radix Ginseng, Hippocampus, Radix Morindae Officinalis, Herba Epimedii, Rhizoma Curculiginis, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, Herba Cistanches, Testis et Pentis Canis, Fructus Lycii, Radix Polygoni Multiflori Preparata, live Lumbricus, Folium Allii tuberosi (fresh), black tea.
Technical background
Along with the quickening of present rhythm of life and the increase of operating pressure, geromorphism, sexual hypofunction or obstacle, energy is not good, yang deficiency is weak, and sub-health state patient numbers increasingly increases and is rejuvenation trend.
Sexual function is a complicated physiological process.The maintenance of normal sexual function relies on the cooperation of human body multisystem, relates to the harmonious of nervous system, cardiovascular system, hormonal system and reproductive system, in addition, also must have the good mental status and healthy psychology.When said system or psychiatric aspect generation ANOMALOUS VARIATIONS, carry out while normal sexuality will be affected, affect the quality of sexual life, show sexual dysfunction.Sexual dysfunction is sexual behaviour and sexy obstacle of feeling, often showing as exception or the disappearance of sexual psychology and physiological reaction, is the general name of multiple different symptoms.Within 40 ~ 70 years old, have 52% to suffer from sexual dysfunction in various degree according to statistics in man, therefore the handicapped treatment of specific aim is a very large market.
In the Drug therapy of sexual dysfunction, Western medicine is different for the treatment of different symptoms: wherein treat erection disturbance, and first-selected PDE5 inhibitor, as sldenafil, Vardenafil, tadanafil etc.; Premature ejaculation can select selectivity 5-serotonin reuptake inhibitor, oral levodopa, ephedrine etc.; Tricyclic antidepressant is therapeutic phobia and depressed choice drug; Corresponding Drug therapy is carried out for having during the mental illness such as anxiety or depression.
Chinese medicine aspect, comprises and has tonifying YANG effect or the handicapped Chinese medicine of treatability.Its common method has Kidney-Nourishing, activating blood and removing stasis Method, method of dissipating heat and detoxifying etc.Wherein the cure mechanism of the conventional Chinese medicine of the treatment of sexual dysfunction has following:
1. the immunologic function of body is improved.Wherein the immunologic function of body comprises cellular immunization and the large class of immunity of organism two.
2. endocrine regulation function is improved.Most of deficient syndrome patient, often visible endocrine gland degeneration or atrophy on pathomorphism, antepituitary, adrenal cortex, thyroid, testis or ovary all present degeneration change in various degree.Also can there is atrophy, degeneration in other histiocytes, this is organ, organizes incompetent material base.
3. hemopoietic function of bone marrow is improved.Be main treatment chronic aplastic anemia with Kidney-Nourishing, curative effect significantly improves.
4. the substance metabolism of body is improved.Promote the biosynthesis of protein, DNA, RNA, improve the activity of RNA polymerase, improve serum albumin synthetic ratio, improve albumin and r-globulin content, promote the division of medullary cell, make erythrocyte, trend that leukocyte has rising.
5. strengthen anti-stress ability, regulating YIN and YANG balances.Many tonifying YANG Chinese medicines can improve the adaptability of body, and enhancing body, to the non-specific resistivity of various destructive stimulus, makes disorderly functional recovery normal.
6. regulating microelement.Research proves, trace element has many important physiological functions (as relevant to sexual function) and biological action, plays extremely important effect in human life activity and metabolic process.
" Plain Questions ancient times innocence opinion ": " husband eight years old, sthenia nephropathy send out dental transition long; Sixteen, kidney qi is contained, the menarche, spermatic ejeculation, negative and positive and, therefore can son be had; Three or eight, adepuate kidney-QI, powerful muscle and bone, therefore growth of wisdom tooth and mature development of the body; Four or eight, muscles and bones is abundant, vigorous and robust muscle; Five or eight, kidney qi declines, trichomadesis withering of teeth; Six or eight, yang-energy exhaustion is in upper, and wrinkly face, sends out temples and issue white; Seven or eight, irritability declines, the tendon being unable to move, exhaustion of kidney-essence with promoting reproductive function, oligospermia, and kidney is hidden and declined, physique and configuration of the body being very feeble and atrophied; Eight or eight, then tooth is sent out ".Point out that growth in humans is strong old, reproduction is multiplied, all led by kidney qi, if hack because giving up completely to natural impulse wound too, impairment of the kidney due to indulgence in sexual activities deficiency of kidney essence, the fire consumption of disorder of emotion phase is cloudy, ponder over overstrain, Qi Bu Photo essence all can cause deficiency of kidney-YIN, vital essence is not solid, decline of the fire from the gate of life, and causes geromorphism, sexual disorder, energy are not good, yang deficiency is weak, sub-health state.This class pathogenesis is kidney qi virtual loss, lose in hair growth promoting, warm, moisten caused by foster, Gu Photo.The suitable strengthening and nourishing marrow and essence of Therapeutic Principle, strong Yuanyang.
From ancient times to the present, the traditional Chinese medical science just record of targeted dysfunction treatment and discussion.Treatment by Chinese herbs comprises and has tonifying YANG effect or the handicapped prescriptions of Chinese medicine of treatability, and its common method has Kidney-Nourishing, activating blood and removing stasis Method, method of dissipating heat and detoxifying etc.
Now, still have many traditional Chinese medical science for the research for the treatment of of sexual dysfunctions, from prescription, preparation, each side such as clinical further investigation, and bear the prescriptions of Chinese medicine emerged in an endless stream accordingly, and applied for Patents.
Prescription of the present invention has certain historical origin, is originally prepared by " YUNNAN BAIYAO " founder Qu Huanzhang and specializes in the military-political important official's use in upper strata, have strengthening and nourishing marrow and essence, strong Yuanyang, the effect of slow down aging, Be very effective.But prescription at that time wherein to include Pericarpium Papaveris, Penis et testis Tigris etc. valuable or forbid medical material.After liberation, improved on original prescription basis by the sub-Qu Jiarui of Qu Huanzhang, abandon valuable with forbid medical material Penis et testis Tigris and Pericarpium Papaveris etc., ins conjunction with process conditions at that time, final formation is easy to obtained prescription and prescription of the present invention.
Summary of the invention
The object of this invention is to provide a kind of prescription of compound Chinese medicinal preparation with kidney invigorating and YANG supporting, the treatment of sexual dysfunction, slow down aging.
Wherein include in this prescription: the medical material such as Cornu Cervi Pantotrichum, Radix Ginseng, Hippocampus, Radix Morindae Officinalis, Herba Epimedii, Rhizoma Curculiginis, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, Herba Cistanches, Testis et Pentis Canis, Fructus Lycii, Radix Polygoni Multiflori Preparata.
Prescription of the present invention, according to the cure mechanism of above Chinese medicine, in conjunction with for the conventional Chinese medicine in mechanism treatment, according to monarch, minister, is helped, makes principles of formulating prescriptions reasonable compatibility and is obtained.Get kidney-Yang invigorating, the Cornu Cervi Pantotrichum of beneficial marrow, the Radix Ginseng of strongly invigorating primordial QI are monarch drug altogether, and QI invigorating tonifying YANG, fills up marrow." Bencao Jingshu " " Cornu Cervi Pantotrichum, report the matter of pure sun, the gas containing hair growth promoting ", " herbal classic is met former " " Cornu Cervi Pantotrichum function, mends fire supporing yang, spermatogenesis benefit marrow." get the Hippocampus of kidney invigorating and YANG supporting, Radix Morindae Officinalis, the Herba Epimedii of invigorating kidney-YANG, the Rhizoma Curculiginis of the kidney warming sun, Fructus Cnidii, the Semen Allii Tuberosi in warming middle-JIAO Yiyang is ministerial drug, to increase principal agent kidney invigorating and YANG supporting effect.Get the Semen Cuscutae of the kidney invigorating and essence nourishing, Herba Cistanches, Testis et Pentis Canis, the Fructus Lycii of Yin-nourishing and Yang-supporting, the Radix Polygoni Multiflori Preparata of kidney tonifying tonifying liver be adjuvant drug, kind YANG invigorating person must give treating YANG within YIN, infinite with aid yang qi biochemistry, can avoid again the scorching impairment of YIN of yang-energy; Get Lumbricus alive for making, the Lumbricus that lives is for having made triple merits, and one is that the full side of salty-cold restriction is warm, and two is that this moral character is walked to alter, and is longer than dredging the meridian QI and blood, and pathogen is evacuated to be had, and righting does not stay heresy, and three is that priming enters Liver and kidney.Make a general survey of full side, melt the reason of interdependence between yin and yang, reach the effect of strengthening vital QI to eliminate pathogenic factors, show the marrow of traditional Chinese medical science prescription fully, close and with play strengthening and nourishing marrow and essence altogether, strong Yuanyang, the merit of the gas of heavily bulging hair growth promoting.
The invention provides a kind of compound Chinese medicinal preparation, is that crude drug is prepared from the Chinese medicine of following weight proportion:
Title |
Number |
Title |
Number |
Title |
Number |
Cornu Cervi Pantotrichum |
0-1 part |
Radix Ginseng |
0-5 part |
Hippocampus |
0-5 part |
Radix Morindae Officinalis |
0-50 part |
Herba Epimedii |
0-30 part |
Rhizoma Curculiginis |
0-50 part |
Fructus Cnidii |
0-20 part |
Semen Allii Tuberosi |
0-50 part |
Herba Cistanches |
0-50 part |
Semen Cuscutae |
0-30 part |
Testis et Pentis Canis |
0-15 part |
Fructus Lycii |
0-50 part |
Radix Polygoni Multiflori Preparata |
0-60 part |
Live Lumbricus |
0-70 part |
Folium Allii tuberosi (fresh) |
0-280 part |
Black tea |
0-60 part |
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More than in composition, the weight of each taste medicine calculates with crude drug, can increase according to corresponding proportion when producing or reduce, as large-scale production can by kilogram in units of, or in units of ton, small-scale production also can by gram or milligram in units of, weight can increase or reduce, but the constant rate of raw medicinal herbs weight proportion between each composition.
As above ratio can to adopt gram as unit of weight according to practical situation, the raw material of Chinese medicine medicine of following weight proportion can prepare compound Chinese medicinal preparation 10000 doses:
Title |
Weight |
Title |
Weight |
Title |
Weight |
Cornu Cervi Pantotrichum |
100-150g |
Radix Ginseng |
400-650g |
Hippocampus |
400-650g |
Radix Morindae Officinalis |
4000-6500g |
Herba Epimedii |
2500-4500g |
Rhizoma Curculiginis |
4000-6500g |
Fructus Cnidii |
1300-2100g |
Semen Allii Tuberosi |
4000-6500g |
Herba Cistanches |
4000-6500g |
Semen Cuscutae |
2500-4500g |
Testis et Pentis Canis |
1100-1700g |
Fructus Lycii |
4000-6500g |
Radix Polygoni Multiflori Preparata |
5000-8500g |
Live Lumbricus |
6900-11000g |
Folium Allii tuberosi (fresh) |
25000-45000g |
Black tea |
5000-8500g |
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Most preferred proportioning is as follows:
Title |
Weight |
Title |
Weight |
Title |
Weight |
Cornu Cervi Pantotrichum |
120g |
Radix Ginseng |
500g |
Hippocampus |
500g |
Radix Morindae Officinalis |
5000g |
Herba Epimedii |
3340g |
Rhizoma Curculiginis |
5000g |
Fructus Cnidii |
1670g |
Semen Allii Tuberosi |
5000g |
Herba Cistanches |
5000g |
Semen Cuscutae |
3340g |
Testis et Pentis Canis |
1330g |
Fructus Lycii |
5000g |
Radix Polygoni Multiflori Preparata |
6670g |
Live Lumbricus |
8340g |
Folium Allii tuberosi (fresh) |
33400g |
Black tea |
6670g |
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|
|
|
Described 10000 agent formulations refer to: the Chinese medicine preparation 10000 doses that can be made into different dosage form, as 10000, tablet, and capsule 10000, granule 10000g, pill 10000 ball etc.
The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is constant.
Chinese medicine preparation of the present invention, being that the raw material of Chinese medicine medical material by being formed by above-mentioned formula is processed through extraction or other modes, making pharmaceutically active substance, subsequently, with this material for raw material, when needing, add medicine acceptable carrier, make according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can be obtained by the common raw material of Chinese medicine medical material that extracts, also can obtain by other means, as: by pulverizing, squeezing, grind, sieve, the material that method obtains, these active substances can be extractum form such as percolation, extraction, water extraction, alcohol extraction, ester carry, chromatography, can be dry extract also can be fluid extract, need to determine to make different concentration according to the difference of preparation.
Pharmaceutical preparation of the present invention, the preferably pharmaceutical dosage forms of unit dose, can make any pharmaceutically useful dosage form when making pharmaceutical preparation, these dosage forms are selected from: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, pill, powder, unguentum, sublimed preparation, suspensoid, solution, injection, suppository, ointment, plaster, cream, spray, patch.Preferably oral dosage form, most preferably capsule, granule.
Pharmaceutical preparation of the present invention, can add some medicine acceptable carriers as required, and galenic pharmacy routine techniques can be adopted to prepare this pharmaceutical preparation, as mixed with medicine acceptable carrier by pharmaceutically active substance.The acceptable carrier of described medicine is selected from: mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, vitamin E, vitamin D, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, soil temperature 60-80, span-80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, agar, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Pharmaceutical preparation of the present invention is in use according to the situation determination usage and dosage of patient.
Chinese medicine preparation of the present invention, when making medicament, the medicament of unit dose can contain pharmaceutically active substance 0.1-1000mg of the present invention, and all the other are pharmaceutically acceptable carrier.Pharmaceutically acceptable carrier can be the 0.1-99.9% of total formulation weight amount by weight.
Below by way of experimental data, beneficial effect of the present invention is described.
The object of this invention is to provide the clinical practice in all fields of this compound Chinese medicinal preparation.
The preparation obtained according to above-mentioned prescription, its major function has: strengthening and nourishing marrow and essence, strong Yuanyang, slow down aging, improves body's immunity and nervous physiology respond, the effects such as improvement hypofunction.Be applicable to the empty or ageing patients of body of kidney qi weakness, the clinical witness of decline of kidney-YANG, be also applicable to the prime of life fleshlinesss, geromorphism, lethargy, waist knee joint is weak, nocturia increases, have a dizzy spell, tinnitus, seminal emission premature ejaculation, Yuanyang thanks to and hyposexuality person.Wherein it is specifically intended that heart disease hypertension severe one forbidding; This effect is invalid to prostate patient.
For better describing the application clinically of the above-mentioned preparation of the present invention, corresponding clinical indication is as follows:
1, building body.To soreness of the waist and knees, extremity fear of cold, nocturia, insomnia and dreamful sleep, dizziness and tinnitus, spontaneous sweating, sensation of oppression over the chest with shortness of breath, emaciation and sallow complexion, inappetence, the diseases such as lethargy have special effect.
2, the kidney invigorating and essence nourishing.To the impotence erectile problem caused by insufficiency of kidney-YANG, spermatorrhea premature ejaculation; It is continuous that women leucorrhea drenches drop, and cold womb is infertile, and menoxenia and hyposexuality person have definite curative effect.
3, cardio and vascular function is improved.Strengthen myocardial contraction, blood vessel dilating, blood fat reducing, improves microcirculation, arrhythmia and the effect such as anti-cardiac muscle and cerebral anoxia.
4, remarkable slow down aging.Improve SOD active, remove LPO free radical, effectively reduce infirmities of age and occur.
5, comprehensive enhancing human body immunity function, increases leukocyte count, prevents and treats the leukocyte count minimizing that various disease causes.
6, improve nervous physiology respond, quick allaying tiredness, accelerate antisecosis, stamina intensifying and explosive force, strengthening the tendons and bones.
For further describing preparation application clinically, with the sample in embodiment 1, according to every twice-daily, each 1, taking 30 days is a course for the treatment of, has following clinical data:
1, kidney qi deficient syndrome
1) curative effect
Group |
Number of cases |
Effective routine % |
Effective routine % |
Invalid routine % |
Total effective rate % |
Expansion group |
13 |
7(53.85%) |
6(46.15%) |
0(0%) |
100% |
2) change for the treatment of front and back integration
Group |
Number of cases |
Before treatment |
After treatment |
Front and back difference |
P |
Expansion group |
13 |
17.1±13.56 |
5.55±5.52 |
11.55±9.15 |
<0.01 |
2, deficiency of kidney-YANG syndrome
1) curative effect
Group |
Number of cases |
Effective routine % |
Effective routine % |
Invalid routine % |
Total effective rate % |
Expansion group |
7 |
3(42.86%) |
3(42.86%) |
1(14.28%) |
85.71% |
2) change for the treatment of front and back integration
Group |
Number of cases |
Before treatment |
After treatment |
Front and back difference |
P |
Expansion group |
7 |
29.85±5.55 |
13.42±7.13 |
16.42±6.77 |
<0.01 |
3, hyposexuality symptom
1) curative effect
Group |
Number of cases |
Effective routine % |
Effective routine % |
Invalid routine % |
Total effective rate % |
Expansion group |
17 |
8(47.06%) |
7(41.18%) |
2(11.76%) |
88.24% |
4, old and feeble disease
1) curative effect
Group |
Number of cases |
Effective routine % |
Effective routine % |
Invalid routine % |
Total effective rate % |
Expansion group |
20 |
10(50%) |
9(45%) |
1(5%) |
95% |
2) change for the treatment of front and back integration
Group |
Number of cases |
Before treatment |
After treatment |
Front and back difference |
P |
Expansion group |
20 |
18.2±5.17 |
6.9±3.96 |
11.3±3.52 |
<0.01 |
5, analysis of adverse reactions
Occur xerostomia phenomenon once in a while in drug administration process, remaining without obvious adverse reaction, before and after above-mentioned example treatment, routine blood test, routine urianlysis have no abnormal changes.
Separately have multiple case as follows:
Case 1: Liu * *, male, 57 years old, first visit soreness of the waist and knees, lassitude and weak, spontaneous perspiration, hyposexuality, pale tongue is fat, thready and weak pulse, Chinese medical discrimination is kidney qi deficient syndrome, and controlling pronephridiostome qi deficiency integration is 24 points, and the old and feeble disease integration of the traditional Chinese medical science is 30 points, blood LPO:5.6nmol/ml, TSOD 40.2u, MnSOD 72u, CuZn SOD 32.2u, CD
350%, CD
429%, CD
820%.LH:13.7MIu/ml, FSH:28.9MIu/ml, through giving the embodiment of the present invention 1 capsule, each 1, every twice-daily, takes 30 days continuously.Control metanephros qi deficiency integration and be only 4 points, the old and feeble disease integration of the traditional Chinese medical science is 9 points, blood LPO:2.2nmol/ml, TSOD 43u, MnSOD 10u, CuZn SOD 35.1u, CD
356%, CD
432%, CD
825%.LH:6.7MIu/ml, FSH:13.1MIu/ml, clinical symptoms is obviously improved.
Case 2: Soviet Union * *, male, 52 years old, first visit asthenia facial edema, soreness of the waist and knees, aversion to cold and cold limbs, forgetful, hyposexuality, light red tongue is fat and moisten, tongue is thick in vain, deep-slow pulse, Chinese medical discrimination is deficiency of kidney-YANG syndrome, and controlling front deficiency of kidney-YANG syndrome integration is 21 points, the old and feeble disease integration of the traditional Chinese medical science is 27 points, blood LPO:5.2nmol/ml, TSOD 41.2u, MnSOD 8.0u, CuZn SOD 29u, CD
354%, CD
432%, CD
823%.LH:10.7MIu/ml, FSH:21.3MIu/ml, through giving the embodiment of the present invention 1 capsule, each 1, every twice-daily, takes 30 days continuously.Control rear deficiency of kidney-YANG syndrome integration and be only 5 points, the old and feeble disease integration of the traditional Chinese medical science is 7 points, blood LPO:1.9nmol/ml, TSOD 45u, MnSOD 11u, CuZn SOD 34u, CD
358%, CD
438%, CD
830%.LH:5.3MIu/ml, FSH:11.2MIu/ml, libido strengthens, and clinical symptoms is improved.
Case 3: Ruan * *, women, 59 years old, the symptoms such as spiritlessness and weakness, soreness of the waist and knees, spontaneous perspiration, hyposexuality of paying a home visit, Chinese medical discrimination was deficiency of kidney-QI 24 points, and the old and feeble disease integration of the traditional Chinese medical science is 28 points.Give the embodiment of the present invention 1 capsule, each 1, every twice-daily, takes 30 days continuously.Control rear deficiency of kidney-QI integration and only have 8 points, the old and feeble disease integration 6 points of the traditional Chinese medical science, clinical symptoms is obviously improved.
To sum up, compound Chinese medicinal preparation of the present invention has the following advantages clinically:
1, toxic and side effects is little, edible safety;
2, clinical practice is extensive, and unisex, drug effect is obvious;
3, compared with similar Chinese medicine, instant effect, the cycle of taking is short, and price is more popular;
4, compared with similar Western medicine, do not have drug dependence, toxic and side effects is little, without obvious adverse reaction.
Detailed description of the invention
Further illustrate the present invention below by several specific embodiment, the concrete data related to and operation etc. are not formed to the restriction of application claims protection domain in embodiment.
Embodiment 1 (capsule)
Prescription:
Title |
Weight |
Title |
Weight |
Title |
Weight |
Cornu Cervi Pantotrichum |
12g |
Radix Ginseng |
50g |
Hippocampus |
50g |
Radix Morindae Officinalis |
500g |
Herba Epimedii |
334g |
Rhizoma Curculiginis |
500g |
Fructus Cnidii |
167g |
Semen Allii Tuberosi |
500g |
Herba Cistanches |
500g |
Semen Cuscutae |
334g |
Testis et Pentis Canis |
133g |
Fructus Lycii |
500g |
Radix Polygoni Multiflori Preparata |
667g |
Live Lumbricus |
834g |
Folium Allii tuberosi (fresh) |
3340g |
Black tea |
667g |
Microcrystalline Cellulose |
90g |
Magnesium stearate |
30g |
1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, be ground into coarse powder, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, and filter, filtrate is for subsequent use;
2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate, for subsequent use;
3) get Folium Camelliae sinensis, decoct with water 1 hour, filter, filtrate is concentrated in right amount, then adds appropriate amount of ethanol precipitation, and filter, filtrate is for subsequent use.
4) get Folium Allii tuberosi, according to 3) method, filtrate is for subsequent use.
5) get Lumbricus alive, clean, soak 6 hours with hydromel (1:1), filter, filtrate sedimentation, gets supernatant for subsequent use.
6) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is for subsequent use.
7) by above-mentioned 1) ~ 6) extracting solution all merges, after mix homogeneously, reconcentration is to extractum shape, with extractum bucket splendid attire.By extractum, at 50-60 DEG C of microwave vacuum drying, dry extract is put into pulverizer and pulverizes, collect qualified dried cream powder.
8) dried cream powder, magnesium stearate and microcrystalline Cellulose are transferred in 3 D motion type high efficient mixer and mix, collecting granules, reinstalls in capsule shells.
Embodiment 2 (tablet)
Prescription: with embodiment 1
1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, be ground into coarse powder, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, and filter, filtrate is for subsequent use;
2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate, for subsequent use;
3) get Folium Camelliae sinensis, decoct with water 1 hour, filter, filtrate is concentrated in right amount, then adds appropriate amount of ethanol precipitation, and filter, filtrate is for subsequent use.
4) get Folium Allii tuberosi, according to 3) method, filtrate is for subsequent use.
5) get Lumbricus alive, clean, soak 6 hours with hydromel (1:1), filter, filtrate sedimentation, gets supernatant for subsequent use.
6) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is for subsequent use.
7) by above-mentioned 1) ~ 6) extracting solution all merges, after mix homogeneously, reconcentration is to extractum shape, with extractum bucket splendid attire.By extractum, at 50-60 DEG C of microwave vacuum drying, dry extract is put into pulverizer and pulverizes, collect qualified dried cream powder.
8) dried cream powder, magnesium stearate and microcrystalline Cellulose are transferred in 3 D motion type high efficient mixer and mix, Homogeneous phase mixing 1 hour, tabletting obtains tablet.
Instructions of taking: oral every day secondary, each a slice.
Embodiment 3 (granule)
Prescription:
Title |
Weight |
Title |
Weight |
Title |
Weight |
Cornu Cervi Pantotrichum |
12g |
Radix Ginseng |
50g |
Hippocampus |
50g |
Radix Morindae Officinalis |
250g |
Herba Epimedii |
200g |
Rhizoma Curculiginis |
200g |
Fructus Cnidii |
180g |
Semen Allii Tuberosi |
500g |
Herba Cistanches |
250g |
Semen Cuscutae |
350g |
Testis et Pentis Canis |
150g |
Fructus Lycii |
500g |
Radix Polygoni Multiflori Preparata |
500g |
Live Lumbricus |
625g |
Folium Allii tuberosi (fresh) |
2500g |
Black tea |
500g |
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Method for making: 1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, be ground into coarse powder, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, and filter, filtrate is for subsequent use;
2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate, for subsequent use;
3) get Folium Camelliae sinensis, decoct with water 1 hour, filter, filtrate is concentrated in right amount, then adds appropriate amount of ethanol precipitation, and filter, filtrate is for subsequent use.
4) get Folium Allii tuberosi, according to 3) method, filtrate is for subsequent use.
5) get Lumbricus alive, clean, soak 6 hours with hydromel (1:1), filter, filtrate sedimentation, gets supernatant for subsequent use.
6) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is for subsequent use.
7) by above-mentioned 1) ~ 6) extracting solution all merges, after mix homogeneously, reconcentration is to extractum shape, with extractum bucket splendid attire.By extractum, at 50-60 DEG C of microwave vacuum drying, dry extract is put into pulverizer and pulverizes, collect qualified dried cream powder.
8) dried cream powder, sucrose, magnesium stearate and microcrystalline Cellulose are transferred in 3 D motion type high efficient mixer mix, collecting granules.
Embodiment 4
Title |
Weight |
Title |
Weight |
Title |
Weight |
Cornu Cervi Pantotrichum |
100g |
Radix Ginseng |
400g |
Hippocampus |
400g |
Radix Morindae Officinalis |
4000g |
Herba Epimedii |
2500g |
Rhizoma Curculiginis |
4000g |
Fructus Cnidii |
1300g |
Semen Allii Tuberosi |
4000g |
Herba Cistanches |
4000g |
Semen Cuscutae |
2500g |
Testis et Pentis Canis |
1100g |
Fructus Lycii |
4000g |
Radix Polygoni Multiflori Preparata |
5000g |
Live Lumbricus |
6900g |
Folium Allii tuberosi (fresh) |
25000g |
Black tea |
5000g |
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Method for making: with embodiment 1,
Embodiment 5
Title |
Weight |
Title |
Weight |
Title |
Weight |
Cornu Cervi Pantotrichum |
150g |
Radix Ginseng |
650g |
Hippocampus |
650g |
Radix Morindae Officinalis |
6500g |
Herba Epimedii |
4500g |
Rhizoma Curculiginis |
6500g |
Fructus Cnidii |
2100g |
Semen Allii Tuberosi |
6500g |
Herba Cistanches |
6500g |
Semen Cuscutae |
4500g |
Testis et Pentis Canis |
1700g |
Fructus Lycii |
6500g |
Radix Polygoni Multiflori Preparata |
8500g |
Live Lumbricus |
11000g |
Folium Allii tuberosi (fresh) |
45000g |
Method for making: with embodiment 1.