CN104689025A - Chinese herbal medicine compound preparation for invigorating kidney and strengthening Yang, treating sexual dysfunction and delaying senescence and preparation method thereof - Google Patents
Chinese herbal medicine compound preparation for invigorating kidney and strengthening Yang, treating sexual dysfunction and delaying senescence and preparation method thereof Download PDFInfo
- Publication number
- CN104689025A CN104689025A CN201510046424.6A CN201510046424A CN104689025A CN 104689025 A CN104689025 A CN 104689025A CN 201510046424 A CN201510046424 A CN 201510046424A CN 104689025 A CN104689025 A CN 104689025A
- Authority
- CN
- China
- Prior art keywords
- ethanol
- radix
- hours
- title
- chinese medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a prescription of a Chinese herbal medicine compound preparation for invigorating kidney and strengthening Yang, treating sexual dysfunction and delaying senescence and a preparation method thereof. The Chinese herbal medicine compound preparation is prepared from the following raw material medicines: cartialgenous, ginseng, sea horse, morinda officinalis, herba epimedii, rhizoma curculiginis, fructus cnidii, semen allii tuberosi, semen cuscutae, cistanche, dog kidney, wolfberry and prepared fleeceflower root.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation and preparation method thereof with kidney invigorating and YANG supporting, the treatment of sexual dysfunction, slow down aging, described compound Chinese medicinal preparation is that crude drug is prepared from: Cornu Cervi Pantotrichum, Radix Ginseng, Hippocampus, Radix Morindae Officinalis, Herba Epimedii, Rhizoma Curculiginis, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, Herba Cistanches, Testis et Pentis Canis, Fructus Lycii, Radix Polygoni Multiflori Preparata with following Chinese medicine.
Technical background
Sexual function is a complicated physiological process.The maintenance of normal sexual function relies on the cooperation of human body multisystem, relates to the harmonious of nervous system, cardiovascular system, hormonal system and reproductive system, in addition, also must have the good mental status and healthy psychology.When said system or psychiatric aspect generation ANOMALOUS VARIATIONS, carry out while normal sexuality will be affected, affect the quality of sexual life, show sexual dysfunction.Sexual dysfunction is sexual behaviour and sexy obstacle of feeling, often showing as exception or the disappearance of sexual psychology and physiological reaction, is the general name of multiple different symptoms.Within 40 ~ 70 years old, have 52% to suffer from sexual dysfunction in various degree according to statistics in man, therefore the handicapped treatment of specific aim is a very large market.
In the Drug therapy of sexual dysfunction, Western medicine is different for the treatment of different symptoms: wherein treat erection disturbance, and first-selected PDE5 inhibitor, as sldenafil, Vardenafil, tadanafil etc.; Premature ejaculation can select selectivity 5-serotonin reuptake inhibitor, oral levodopa, ephedrine etc.; Tricyclic antidepressant is therapeutic phobia and depressed choice drug; Corresponding Drug therapy is carried out for having during the mental illness such as anxiety or depression.
Chinese medicine aspect, comprises and has tonifying YANG effect or the handicapped Chinese medicine of treatability.Its common method has Kidney-Nourishing, activating blood and removing stasis Method, method of dissipating heat and detoxifying etc.Wherein the cure mechanism of the conventional Chinese medicine of the treatment of sexual dysfunction has following:
1. the immunologic function of body is improved.Wherein the immunologic function of body comprises cellular immunization and the large class of immunity of organism two.
2. endocrine regulation function is improved.Most of deficient syndrome patient, often visible endocrine gland degeneration or atrophy on pathomorphism, antepituitary, adrenal cortex, thyroid, testis or ovary all present degeneration change in various degree.Also can there is atrophy, degeneration in other histiocytes, this is organ, organizes incompetent material base.
3. hemopoietic function of bone marrow is improved.Be main treatment chronic aplastic anemia with Kidney-Nourishing, curative effect significantly improves.
4. the substance metabolism of body is improved.Promote the biosynthesis of protein, DNA, RNA, improve the activity of RNA polymerase, improve serum albumin synthetic ratio, improve albumin and r-globulin content, promote the division of medullary cell, make erythrocyte, trend that leukocyte has rising.
5. strengthen anti-stress ability, regulating YIN and YANG balances.Many tonifying YANG Chinese medicines can improve the adaptability of body, and enhancing body, to the non-specific resistivity of various destructive stimulus, makes disorderly functional recovery normal.
6. regulating microelement.Research proves, trace element has many important physiological functions (as relevant to sexual function) and biological action, plays extremely important effect in human life activity and metabolic process.
From ancient times to the present, the traditional Chinese medical science just record of targeted dysfunction treatment and discussion.Treatment by Chinese herbs comprises and has tonifying YANG effect or the handicapped prescriptions of Chinese medicine of treatability, and its common method has Kidney-Nourishing, activating blood and removing stasis Method, method of dissipating heat and detoxifying etc.
Now, still have many traditional Chinese medical science for the research for the treatment of of sexual dysfunctions, from prescription, preparation, each side such as clinical further investigation, and bear the prescriptions of Chinese medicine emerged in an endless stream accordingly, and applied for Patents.
Prescription of the present invention is the secret prescription handed down in the family from generation to generation prepared by " YUNNAN BAIYAO " founder Qu Huanzhang, after arrange preparation by its sub-Qu Jiarui, according to the cure mechanism of above Chinese medicine, in conjunction with for mechanism treatment in conventional Chinese medicine, according to monarch, minister, help, make principles of formulating prescriptions reasonable compatibility and obtain, then improve improvement further by bent family descendant and obtain prescription of the present invention.
Prescription of the present invention has certain historical origin, is originally prepared by " YUNNAN BAIYAO " founder Qu Huanzhang and is supplied to the health product of Yunnan governor specially, however prescription at that time wherein to include Pericarpium Papaveris, Penis et testis Tigris etc. valuable or forbid medical material.After liberation, improved on original prescription basis by the sub-Qu Jiarui of Qu Huanzhang, abandon valuable with forbid medical material Penis et testis Tigris and Pericarpium Papaveris etc., ins conjunction with process conditions at that time, final formation is easy to obtained prescription and prescription of the present invention.
Summary of the invention
The object of this invention is to provide a kind of prescription of compound Chinese medicinal preparation with kidney invigorating and YANG supporting, the treatment of sexual dysfunction, slow down aging.
Wherein include in this prescription: Cornu Cervi Pantotrichum, Radix Ginseng, Hippocampus, Radix Morindae Officinalis, Herba Epimedii, Rhizoma Curculiginis, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, Herba Cistanches, Testis et Pentis Canis, Fructus Lycii, Radix Polygoni Multiflori Preparata be totally ten three taste Chinese medicines.
This prescription according to monarch, minister, help, make principles of formulating prescriptions reasonable compatibility, get kidney-Yang invigorating, the Cornu Cervi Pantotrichum of beneficial marrow, the Radix Ginseng of strongly invigorating primordial QI are monarch drug altogether, and QI invigorating tonifying YANG, fills up marrow; Get the Hippocampus of kidney invigorating and YANG supporting, Radix Morindae Officinalis, the Herba Epimedii of invigorating kidney-YANG, the Rhizoma Curculiginis of the kidney warming sun, Fructus Cnidii, warming middle-JIAO Yiyang Semen Allii Tuberosi be ministerial drug, to increase main kidney invigorating and YANG supporting effect; Get the Semen Cuscutae of the kidney invigorating and essence nourishing, Herba Cistanches, Testis et Pentis Canis, the Fructus Lycii of Yin-nourishing and Yang-supporting, the Radix Polygoni Multiflori Preparata of kidney tonifying tonifying liver be adjuvant drug, kind YANG invigorating person must give treating YANG within YIN, to help principal agent life essence-filling, marrow-benefitting.In addition, Radix Polygoni Multiflori Preparata can also play effect of pathogenic fire reducing, prevents other taste Chinese medicines of this prescription from causing the side effect of getting angry.
The invention provides a kind of compound Chinese medicinal preparation, is that crude drug is prepared from the Chinese medicine of following weight proportion:
Title | Number | Title | Number | Title | Number |
Cornu Cervi Pantotrichum | 0-1 part | Radix Ginseng | 0-5 part | Hippocampus | 0-5 part |
Radix Morindae Officinalis | 0-50 part | Herba Epimedii | 0-40 part | Rhizoma Curculiginis | 0-50 part |
Fructus Cnidii | 0-20 part | Semen Allii Tuberosi | 0-50 part | Herba Cistanches | 0-50 part |
Semen Cuscutae | 0-40 part | Testis et Pentis Canis | 0-20 part | Fructus Lycii | 0-50 part |
Radix Polygoni Multiflori Preparata | 0-60 part | Microcrystalline Cellulose | 0-10 part | Magnesium stearate | 0-5 part |
Compound Chinese medicinal preparation of the present invention, if preferred employing gram is unit of weight, is that crude drug is prepared from the Chinese medicine of following weight proportion:
Title | Weight | Title | Weight | Title | Weight |
Cornu Cervi Pantotrichum | 100-150g | Radix Ginseng | 400-600g | Hippocampus | 400-600g |
Radix Morindae Officinalis | 4000-6000g | Herba Epimedii | 4000-5000g | Rhizoma Curculiginis | 4000-6000g |
Fructus Cnidii | 1500-2000g | Semen Allii Tuberosi | 4000-6000g | Herba Cistanches | 4000-6000g |
Semen Cuscutae | 3000-4000g | Testis et Pentis Canis | 1200-1600g | Fructus Lycii | 4000-6000g |
Radix Polygoni Multiflori Preparata | 5000-7000g |
Compound Chinese medicinal preparation of the present invention, if most preferred employing gram is unit of weight, is that crude drug is prepared from the Chinese medicine of following weight proportion:
Title | Weight | Title | Weight | Title | Weight |
Cornu Cervi Pantotrichum | 120g | Radix Ginseng | 500g | Hippocampus | 500g |
Radix Morindae Officinalis | 5000g | Herba Epimedii | 3500g | Rhizoma Curculiginis | 5000g |
Fructus Cnidii | 1800g | Semen Allii Tuberosi | 5000g | Herba Cistanches | 5000g |
Semen Cuscutae | 3500g | Testis et Pentis Canis | 1500g | Fructus Lycii | 5000g |
Radix Polygoni Multiflori Preparata | 6000g |
More than in composition, the weight of each taste medicine calculates with crude drug, can increase according to corresponding proportion when producing or reduce, as large-scale production can by kilogram in units of, or in units of ton, small-scale production also can by gram or milligram in units of, weight can increase or reduce, but the constant rate of raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is constant.
Chinese medicine preparation of the present invention, being that the raw material of Chinese medicine medical material by being formed by above-mentioned formula is processed through extraction or other modes, making pharmaceutically active substance, subsequently, with this material for raw material, when needing, add medicine acceptable carrier, make according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can be obtained by the common raw material of Chinese medicine medical material that extracts, also can obtain by other means, as: by pulverizing, squeezing, grind, sieve, the material that method obtains, these active substances can be extractum form such as percolation, extraction, water extraction, alcohol extraction, ester carry, chromatography, can be dry extract also can be fluid extract, need to determine to make different concentration according to the difference of preparation.
Pharmaceutical preparation of the present invention, the preferably pharmaceutical dosage forms of unit dose, can make any pharmaceutically useful dosage form when making pharmaceutical preparation, these dosage forms are selected from: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, pill, powder, unguentum, sublimed preparation, suspensoid, solution, injection, suppository, ointment, plaster, cream, spray, patch.Preferably oral dosage form, most preferably capsule, granule.
Pharmaceutical preparation of the present invention, can add some medicine acceptable carriers as required, and galenic pharmacy routine techniques can be adopted to prepare this pharmaceutical preparation, as mixed with medicine acceptable carrier by pharmaceutically active substance.The acceptable carrier of described medicine is selected from: mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, vitamin E, vitamin D, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, soil temperature 60-80, span-80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, agar, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Pharmaceutical preparation of the present invention is in use according to the situation determination usage and dosage of patient.
Chinese medicine preparation of the present invention, when making medicament, the medicament of unit dose can contain pharmaceutically active substance 0.1-1000mg of the present invention, and all the other are pharmaceutically acceptable carrier.Pharmaceutically acceptable carrier can be the 0.1-99.9% of total formulation weight amount by weight.
Pharmaceutical preparation of the present invention, its pharmaceutically active substance is through that to extract processing obtained, as following processing method:
Its preparation method, its step is as follows:
1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, filters, is concentrated into appropriate extractum I for subsequent use;
2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate extractum II, for subsequent use;
3) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is concentrated into appropriate extractum III, for subsequent use.
4) after above-mentioned I ~ III extractum concentrated solution all being merged mix homogeneously with 90% ethanol, reconcentration is to smart paste; load in stainless steel disc; dry 48 hours of 50 ~ 60 DEG C of reduced vacuum in vacuum drying oven, rear taking-up is poured in granulator to granulate and is weighed, and obtains granule for subsequent use.
5) get microcrystalline Cellulose, magnesium stearate, pulverize with high speed disintegrator and cross 100 mesh sieves, in 100 DEG C of drying under reduced pressure more than 10 hours, be chilled to room temperature for subsequent use.
6) mix with the adjuvant of 5 steps according to the granule of prescription ratio by 4 step gained, pour mixer Homogeneous phase mixing after mixing into 1 hour, rear taking-up is distributed into the preparation of respective numbers, target product.
Below by way of experimental data, beneficial effect of the present invention is described.
The present invention is with the sample in embodiment 1, and according to every twice-daily, each 1, taking 30 days is a course for the treatment of, has following clinical therapeutic efficacy:
1, kidney qi deficient syndrome
1) curative effect
Group | Number of cases | Effective routine % | Effective routine % | Invalid routine % | Total effective rate % |
Expansion group | 13 | 7(53.85%) | 6(46.15%) | 0(0%) | 100% |
2) change for the treatment of front and back integration
Group | Number of cases | Before treatment | After treatment | Front and back difference | P |
Expansion group | 13 | 17.1±13.56 | 5.55±5.52 | 11.55±9.15 | <0.01 |
2, deficiency of kidney-YANG syndrome
1) curative effect
Group | Number of cases | Effective routine % | Effective routine % | Invalid routine % | Total effective rate % |
Expansion group | 7 | 3(42.86%) | 3(42.86%) | 1(14.28%) | 85.71% |
2) change for the treatment of front and back integration
Group | Number of cases | Before treatment | After treatment | Front and back difference | P |
Expansion group | 7 | 29.85±5.55 | 13.42±7.13 | 16.42±6.77 | <0.01 |
3, hyposexuality symptom
1) curative effect
Group | Number of cases | Effective routine % | Effective routine % | Invalid routine % | Total effective rate % |
Expansion group | 17 | 8(47.06%) | 7(41.18%) | 2(11.76%) | 88.24% |
4, old and feeble disease
1) curative effect
Group | Number of cases | Effective routine % | Effective routine % | Invalid routine % | Total effective rate % |
Expansion group | 20 | 10(50%) | 9(45%) | 1(5%) | 95% |
2) change for the treatment of front and back integration
Group | Number of cases | Before treatment | After treatment | Front and back difference | P |
Expansion group | 20 | 18.2±5.17 | 6.9±3.96 | 11.3±3.52 | <0.01 |
5, analysis of adverse reactions
Occur xerostomia phenomenon once in a while in drug administration process, remaining without obvious adverse reaction, before and after above-mentioned example treatment, routine blood test, routine urianlysis have no abnormal changes.
Show according to above-mentioned clinical practice data, the preparation obtained according to this prescription is verified really effectively and successful in multinomial clinical practice, and malicious attached effect is little.
Separately have multiple case as follows:
Case 1: Liu * *, male, 57 years old, first visit soreness of the waist and knees, lassitude and weak, spontaneous perspiration, hyposexuality, pale tongue is fat, thready and weak pulse, Chinese medical discrimination is kidney qi deficient syndrome, and controlling pronephridiostome qi deficiency integration is 24 points, and the old and feeble disease integration of the traditional Chinese medical science is 30 points, blood LPO:5.6nmol/ml, TSOD 40.2u, MnSOD 72u, CuZn SOD 32.2u, CD
350%, CD
429%, CD
820%.LH:13.7MIu/ml, FSH:28.9MIu/ml, through giving the embodiment of the present invention 1 capsule, each 1, every twice-daily, takes 30 days continuously.Control metanephros qi deficiency integration and be only 4 points, the old and feeble disease integration of the traditional Chinese medical science is 9 points, blood LPO:2.2nmol/ml, TSOD 43u, MnSOD 10u, CuZn SOD 35.1u, CD
356%, CD
432%, CD
825%.LH:6.7MIu/ml, FSH:13.1MIu/ml, clinical symptoms is obviously improved.
Case 2: Soviet Union * *, male, 52 years old, first visit asthenia facial edema, soreness of the waist and knees, aversion to cold and cold limbs, forgetful, hyposexuality, light red tongue is fat and moisten, tongue is thick in vain, deep-slow pulse, Chinese medical discrimination is deficiency of kidney-YANG syndrome, and controlling front deficiency of kidney-YANG syndrome integration is 21 points, the old and feeble disease integration of the traditional Chinese medical science is 27 points, blood LPO:5.2nmol/ml, TSOD 41.2u, MnSOD 8.0u, CuZn SOD 29u, CD
354%, CD
432%, CD
823%.LH:10.7MIu/ml, FSH:21.3MIu/ml, through giving the embodiment of the present invention 1 capsule, each 1, every twice-daily, takes 30 days continuously.Control rear deficiency of kidney-YANG syndrome integration and be only 5 points, the old and feeble disease integration of the traditional Chinese medical science is 7 points, blood LPO:1.9nmol/ml, TSOD 45u, MnSOD 11u, CuZn SOD 34u, CD
358%, CD
438%, CD
830%.LH:5.3MIu/ml, FSH:11.2MIu/ml, libido strengthens, and clinical symptoms is improved.
Case 3: Ruan * *, women, 59 years old, the symptoms such as spiritlessness and weakness, soreness of the waist and knees, spontaneous perspiration, hyposexuality of paying a home visit, Chinese medical discrimination was deficiency of kidney-QI 24 points, and the old and feeble disease integration of the traditional Chinese medical science is 28 points.Give the embodiment of the present invention 1 capsule, each 1, every twice-daily, takes 30 days continuously.Control rear deficiency of kidney-QI integration and only have 8 points, the old and feeble disease integration 6 points of the traditional Chinese medical science, clinical symptoms is obviously improved.
In sum, Chinese medicine preparation prescription of the present invention has the following advantages in prescription, technique:
1, prescription medical material is all easy to get, and collocation rationally, not easily gets angry;
2, processing procedure is simple to operation, without the need to special installation, is applicable to amplifying commercial production;
3, multi-flavor medicine can process simultaneously, without the need to processing every taste prescription one, saves operation;
4, concocting process single solvent ethanol, recycling capable of circulation, reduces environmental protection and production cost;
5, whole processing procedure meets the requirement of modernization process, can produce the product that quality is secure.
Detailed description of the invention
Further illustrate the present invention below by several specific embodiment, the concrete data related to and operation etc. are not formed to the restriction of application claims protection domain in embodiment.
Embodiment 1 (capsule)
Prescription:
Title | Weight | Title | Weight | Title | Weight |
Cornu Cervi Pantotrichum | 12g | Radix Ginseng | 50g | Hippocampus | 50g |
Radix Morindae Officinalis | 500g | Herba Epimedii | 350g | Rhizoma Curculiginis | 500g |
Fructus Cnidii | 180g | Semen Allii Tuberosi | 500g | Herba Cistanches | 500g |
Semen Cuscutae | 350g | Testis et Pentis Canis | 150g | Fructus Lycii | 500g |
Radix Polygoni Multiflori Preparata | 600g | Microcrystalline Cellulose | 80g | Magnesium stearate | 20g |
1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, filters, is concentrated into appropriate extractum I for subsequent use;
2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate extractum II, for subsequent use;
3) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is concentrated into appropriate extractum III, for subsequent use.
4) after above-mentioned I ~ III extractum concentrated solution all being merged mix homogeneously with 90% ethanol, reconcentration is to smart paste; load in stainless steel disc; dry 48 hours of 50 ~ 60 DEG C of reduced vacuum in vacuum drying oven, rear taking-up is poured in granulator to granulate and is weighed, and obtains granule for subsequent use.
5) get microcrystalline Cellulose, magnesium stearate, pulverize with high speed disintegrator and cross 100 mesh sieves, in 100 DEG C of drying under reduced pressure more than 10 hours, be chilled to room temperature for subsequent use.
6) mix with the adjuvant of 5 steps according to the granule of prescription ratio by 4 step gained, pour mixer Homogeneous phase mixing into 1 hour after mixing, rear taking-up is distributed into the capsule 1000 of respective numbers.
Instructions of taking: oral every day secondary, each one.
Embodiment 2 (tablet)
Prescription: with embodiment 1
1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, filters, is concentrated into appropriate extractum I for subsequent use;
2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate extractum II, for subsequent use;
3) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is concentrated into appropriate extractum III, for subsequent use.
4) after above-mentioned I ~ III extractum concentrated solution all being merged mix homogeneously with 90% ethanol, reconcentration is to smart paste; load in stainless steel disc; dry 48 hours of 50 ~ 60 DEG C of reduced vacuum in vacuum drying oven, rear taking-up is poured in granulator to granulate and is weighed, and obtains granule for subsequent use.
5) get microcrystalline Cellulose, magnesium stearate, pulverize with high speed disintegrator and cross 100 mesh sieves, in 100 DEG C of drying under reduced pressure more than 10 hours, be chilled to room temperature for subsequent use.
6) mix with the adjuvant of 5 steps according to the granule of prescription ratio by 4 step gained, pour mixer Homogeneous phase mixing into 1 hour after mixing, tabletting obtains 1000, tablet.
Instructions of taking: oral every day secondary, each a slice.
Embodiment 3 (capsule)
Prescription:
Title | Weight | Title | Weight | Title | Weight |
Cornu Cervi Pantotrichum | 12g | Radix Ginseng | 50g | Hippocampus | 50g |
Radix Morindae Officinalis | 250g | Herba Epimedii | 200g | Rhizoma Curculiginis | 200g |
Fructus Cnidii | 180g | Semen Allii Tuberosi | 500g | Herba Cistanches | 250g |
Semen Cuscutae | 350g | Testis et Pentis Canis | 150g | Fructus Lycii | 500g |
Radix Polygoni Multiflori Preparata | 500g | Microcrystalline Cellulose | 80g | Magnesium stearate | 20g |
Method for making: with embodiment 1.
Instructions of taking: oral every day three times, each one.
Embodiment 4 (granule)
Prescription:
Title | Weight | Title | Weight | Title | Weight |
Cornu Cervi Pantotrichum | 12g | Radix Ginseng | 50g | Hippocampus | 50g |
Radix Morindae Officinalis | 250g | Herba Epimedii | 200g | Rhizoma Curculiginis | 200g |
Fructus Cnidii | 180g | Semen Allii Tuberosi | 500g | Herba Cistanches | 250g |
Semen Cuscutae | 350g | Testis et Pentis Canis | 150g | Fructus Lycii | 500g |
Radix Polygoni Multiflori Preparata | 500g |
1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, filters, is concentrated into appropriate extractum I for subsequent use;
2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate extractum II, for subsequent use;
3) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is concentrated into appropriate extractum III, for subsequent use.
4) after above-mentioned I ~ III extractum concentrated solution all being merged mix homogeneously with 90% ethanol, reconcentration is to smart paste; load in stainless steel disc; dry 48 hours of 50 ~ 60 DEG C of reduced vacuum in vacuum drying oven, rear taking-up is poured in granulator to granulate and is weighed, and obtains granule for subsequent use.
5) get microcrystalline Cellulose, magnesium stearate, pulverize with high speed disintegrator and cross 100 mesh sieves, in 100 DEG C of drying under reduced pressure more than 10 hours, be chilled to room temperature for subsequent use.
6) mix with the adjuvant of 5 steps according to the granule of prescription ratio by 4 step gained, pour mixer Homogeneous phase mixing after mixing into 1 hour, be distributed into granule.
Instructions of taking: taken with boiled water once a day, each one bag.
Embodiment 5 (capsule)
Title | Weight | Title | Weight | Title | Weight |
[0111]
Cornu Cervi Pantotrichum | 100g | Radix Ginseng | 400g | Hippocampus | 400g |
Radix Morindae Officinalis | 4000g | Herba Epimedii | 4000g | Rhizoma Curculiginis | 4000g |
Fructus Cnidii | 1500g | Semen Allii Tuberosi | 4000g | Herba Cistanches | 4000g |
Semen Cuscutae | 3000g | Testis et Pentis Canis | 1200g | Fructus Lycii | 4000g |
Radix Polygoni Multiflori Preparata | 5000g |
Method for making: with embodiment 1, is prepared into 10000.
Instructions of taking: oral every day three times, each one.
Embodiment 6 (capsule)
Title | Weight | Title | Weight | Title | Weight |
Cornu Cervi Pantotrichum | 150g | Radix Ginseng | 600g | Hippocampus | 600g |
Radix Morindae Officinalis | 6000g | Herba Epimedii | 5000g | Rhizoma Curculiginis | 6000g |
Fructus Cnidii | 2000g | Semen Allii Tuberosi | 6000g | Herba Cistanches | 6000g |
Semen Cuscutae | 4000g | Testis et Pentis Canis | 1600g | Fructus Lycii | 6000g |
Radix Polygoni Multiflori Preparata | 7000g |
Method for making: with embodiment 1, is prepared into 10000.
Instructions of taking: oral every day three times, each one.
Claims (8)
1. a compound Chinese medicinal preparation is that crude drug is prepared from the Chinese medicine of following weight proportion:
。
2. compound Chinese medicinal preparation according to claim 1 is that crude drug is prepared from the Chinese medicine of following weight proportion:
。
3. compound Chinese medicinal preparation according to claim 1 is that crude drug is prepared from the Chinese medicine of following weight proportion:
。
4. compound Chinese medicinal preparation according to claim 1 is peroral dosage form.
5. compound Chinese medicinal preparation according to claim 1 is tablet, capsule, granule.
6. compound Chinese medicinal preparation according to claim 1 is capsule.
7. compound Chinese medicinal preparation according to claim 1,10000 seed lac wafers are prepared from order to lower weight proportion raw material:
。
8. the preparation method of compound Chinese medicinal preparation according to claim 1, its step is as follows:
1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, filters, is concentrated into appropriate extractum I for subsequent use;
2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate extractum II, for subsequent use;
3) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is concentrated into appropriate extractum III, for subsequent use.
4) after above-mentioned I ~ III extractum concentrated solution all being merged mix homogeneously with 90% ethanol, reconcentration is to smart paste; load in stainless steel disc; dry 48 hours of 50 ~ 60 DEG C of reduced vacuum in vacuum drying oven, rear taking-up is poured in granulator to granulate and is weighed, and obtains granule for subsequent use.
5) get microcrystalline Cellulose, magnesium stearate, pulverize with high speed disintegrator and cross 100 mesh sieves, in 100 DEG C of drying under reduced pressure more than 10 hours, be chilled to room temperature for subsequent use.
6) mix with the adjuvant of 5 steps according to the granule of prescription ratio by 4 step gained, pour mixer Homogeneous phase mixing after mixing into 1 hour, rear taking-up is distributed into the preparation of respective numbers, target product.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510046424.6A CN104689025A (en) | 2015-01-29 | 2015-01-29 | Chinese herbal medicine compound preparation for invigorating kidney and strengthening Yang, treating sexual dysfunction and delaying senescence and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510046424.6A CN104689025A (en) | 2015-01-29 | 2015-01-29 | Chinese herbal medicine compound preparation for invigorating kidney and strengthening Yang, treating sexual dysfunction and delaying senescence and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104689025A true CN104689025A (en) | 2015-06-10 |
Family
ID=53336849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510046424.6A Pending CN104689025A (en) | 2015-01-29 | 2015-01-29 | Chinese herbal medicine compound preparation for invigorating kidney and strengthening Yang, treating sexual dysfunction and delaying senescence and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104689025A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105412353A (en) * | 2015-09-11 | 2016-03-23 | 皮山御盛金茂生物科技有限公司 | Traditional Chinese medicine combination with functions of resisting senility, improving immunity, resisting fatigue and keeping healthy |
CN105770392A (en) * | 2016-02-18 | 2016-07-20 | 西安圣威制药有限公司 | Traditional Chinese medicine composition for invigorating kidney and strengthening Yang and enriching essence and supplementing marrow and preparation method thereof |
CN107349314A (en) * | 2017-07-11 | 2017-11-17 | 东新皓特(北京)生化科技有限公司 | Application and pharmaceutical composition of the tetraodotoxin in the middle-aged and old hypogona dism disorder agent compositions for the treatment of are prepared |
CN112089788A (en) * | 2020-10-21 | 2020-12-18 | 江西五麟祥生物科技有限公司 | Cynomorium songaricum and epimedium yang strengthening spray for men |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1634296A (en) * | 2004-09-30 | 2005-07-06 | 广州华博生物制药研究所 | Medicine for treating male infertility |
EP1862171A1 (en) * | 2006-06-02 | 2007-12-05 | Hebei Yiling Medicine Research Institute Co., Ltd. | A medicine composition for treating muscular atrophy and myasthenia gravis and method of preparing the same |
-
2015
- 2015-01-29 CN CN201510046424.6A patent/CN104689025A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1634296A (en) * | 2004-09-30 | 2005-07-06 | 广州华博生物制药研究所 | Medicine for treating male infertility |
EP1862171A1 (en) * | 2006-06-02 | 2007-12-05 | Hebei Yiling Medicine Research Institute Co., Ltd. | A medicine composition for treating muscular atrophy and myasthenia gravis and method of preparing the same |
Non-Patent Citations (4)
Title |
---|
周长坚等: "曲氏健男春的补肾壮阳作用", 《福建中医学院学报》 * |
国家食品药品监督管理局执业药师资格认证中心: "《中药学专业知识.1》", 31 January 2014 * |
李谦等: "《中老年虚证补益调治良方》", 30 November 1998, 人民卫生出版社 * |
潘馨: "健男春质量标准研究", 《海峡药学》 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105412353A (en) * | 2015-09-11 | 2016-03-23 | 皮山御盛金茂生物科技有限公司 | Traditional Chinese medicine combination with functions of resisting senility, improving immunity, resisting fatigue and keeping healthy |
CN105770392A (en) * | 2016-02-18 | 2016-07-20 | 西安圣威制药有限公司 | Traditional Chinese medicine composition for invigorating kidney and strengthening Yang and enriching essence and supplementing marrow and preparation method thereof |
CN105770392B (en) * | 2016-02-18 | 2020-06-09 | 西安圣威制药有限公司 | A Chinese medicinal composition for invigorating kidney, supporting yang, replenishing essence and replenishing marrow, and its preparation method |
CN107349314A (en) * | 2017-07-11 | 2017-11-17 | 东新皓特(北京)生化科技有限公司 | Application and pharmaceutical composition of the tetraodotoxin in the middle-aged and old hypogona dism disorder agent compositions for the treatment of are prepared |
CN112089788A (en) * | 2020-10-21 | 2020-12-18 | 江西五麟祥生物科技有限公司 | Cynomorium songaricum and epimedium yang strengthening spray for men |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104547467A (en) | Traditional Chinese medicine compound preparation with functions of invigorating kidneys, strengthening yang, treating sexual dysfunction and delaying senescence and application of traditional Chinese medicine compound preparation | |
CN105267943A (en) | Lumbricus bioactive small peptide effective part composition | |
CN104689025A (en) | Chinese herbal medicine compound preparation for invigorating kidney and strengthening Yang, treating sexual dysfunction and delaying senescence and preparation method thereof | |
CN102293927B (en) | Compound Chinese medicinal preparation with antifatigue and antioxidation effects, and preparation method thereof | |
CN101053621B (en) | Traditional Chinese medicinal composition for treating obesity and its preparation method | |
CN103099833A (en) | Soft capsule helpful for relieving sports fatigue and delaying aging and preparation method thereof | |
CN1109554C (en) | Medicine for treating allergic purpura | |
CN102078569A (en) | Traditional Chinese medicine preparation for treating liver cancer and preparation method thereof | |
CN104840706B (en) | A kind of to physiology compound Chinese medicinal preparation having multi-function action and preparation method thereof | |
CN100421699C (en) | Compound Chinese medicinal preparation for treating male sterility | |
CN102526444A (en) | Traditional Chinese medicine composition for invigorating kidney and strengthening yang and preparation method thereof | |
CN104815134B (en) | A kind of pair of physiology has the compound Chinese medicinal preparation and its application of multi-function action | |
CN113456778A (en) | Composition for improving energy and preparation method thereof | |
CN1192789C (en) | 'Shenhuaxiaokecha' tea and preparing method thereof | |
CN105477465A (en) | Chinese herb preparation with liver protection function and preparing technology of Chinese herb preparation | |
KR20020023456A (en) | Granular food composition for health comprising kalopanacis cortex as main ingredient | |
CN106421200B (en) | A kind of Chinese medicine composition for treating infertility | |
CN103877513A (en) | Chinese herbal compound composition with blood fat reduction effect, and applications thereof | |
CN101642541B (en) | Composition with hepatoprotective effect, preparation method and application thereof | |
CN105079463A (en) | Chinese herbal preparation used for treating cardiovascular diseases and preparation method of Chinese herbal preparation | |
CN104491762A (en) | Medicine composition for treating traumatic injury and preparation method | |
CN101088555B (en) | Medicine preparation for inhibiting tumor angiogenesis and cancer cell and enhancing immunity | |
CN104107308A (en) | Medicament for treating haemorrhoids and preparation method thereof | |
CN104324332A (en) | Traditional Chinese medicine preparation for treating liver-qi stagnation type chloasma and production method of traditional Chinese medicine preparation | |
CN104173521B (en) | A kind of pharmaceutical composition and its preparation method giving birth to able-bodied sun |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150610 |
|
RJ01 | Rejection of invention patent application after publication | ||
DD01 | Delivery of document by public notice |
Addressee: Fu Chongan Document name: Notification of Termination of Procedure |
|
DD01 | Delivery of document by public notice |