CN104547467A - Traditional Chinese medicine compound preparation with functions of invigorating kidneys, strengthening yang, treating sexual dysfunction and delaying senescence and application of traditional Chinese medicine compound preparation - Google Patents

Abstract

The invention relates to a traditional Chinese medicine compound preparation with functions of invigorating the kidneys, strengthening yang, treating sexual dysfunction and delaying senescence and application of the traditional Chinese medicine compound preparation. The traditional Chinese medicine compound preparation is prepared from the following traditional Chinese medicines as raw materials: corn cervi pantotrichum, ginseng, hippocampus, morinda officinalis, herba epimedii, curculigo orchioides, fructus cnidii, semen allii tuberose, semen cuscutae, cistanche salsa, madindarby canine kidney, wolfberry and processed polygonum multiflorum. The application specifically comprises clinical application in invigorating the kidneys, strengthening yang, treating sexual dysfunction and delaying senescence. The traditional Chinese medicine compound preparation has the main functions of strengthening and nourishing marrow and essence, strengthening kidney-yang, delaying senescence, improving the organism immune function and neural physiological reaction ability, and improving sexual under-function.

Description

A kind of have kidney invigorating and YANG supporting, the treatment of sexual dysfunction, the compound Chinese medicinal preparation of slow down aging and application thereof

Technical field

The present invention relates to a kind of compound Chinese medicinal preparation and preparation method thereof with kidney invigorating and YANG supporting, the treatment of sexual dysfunction, slow down aging, described compound Chinese medicinal preparation is that crude drug is prepared from: Cornu Cervi Pantotrichum, Radix Ginseng, Hippocampus, Radix Morindae Officinalis, Herba Epimedii, Rhizoma Curculiginis, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, Herba Cistanches, Testis et Pentis Canis, Fructus Lycii, Radix Polygoni Multiflori Preparata with following Chinese medicine.

Technical background

Sexual function is a complicated physiological process.The maintenance of normal sexual function relies on the cooperation of human body multisystem, relates to the harmonious of nervous system, cardiovascular system, hormonal system and reproductive system, in addition, also must have the good mental status and healthy psychology.When said system or psychiatric aspect generation ANOMALOUS VARIATIONS, carry out while normal sexuality will be affected, affect the quality of sexual life, show sexual dysfunction.Sexual dysfunction is sexual behaviour and sexy obstacle of feeling, often showing as exception or the disappearance of sexual psychology and physiological reaction, is the general name of multiple different symptoms.Within 40 ~ 70 years old, have 52% to suffer from sexual dysfunction in various degree according to statistics in man, therefore the handicapped treatment of specific aim is a very large market.

In the Drug therapy of sexual dysfunction, Western medicine is different for the treatment of different symptoms: wherein treat erection disturbance, and first-selected PDE5 inhibitor, as sldenafil, Vardenafil, tadanafil etc.; Premature ejaculation can select selectivity 5-serotonin reuptake inhibitor, oral levodopa, ephedrine etc.; Tricyclic antidepressant is therapeutic phobia and depressed choice drug; Corresponding Drug therapy is carried out for having during the mental illness such as anxiety or depression.

Chinese medicine aspect, comprises and has tonifying YANG effect or the handicapped Chinese medicine of treatability.Its common method has Kidney-Nourishing, activating blood and removing stasis Method, method of dissipating heat and detoxifying etc.Wherein the cure mechanism of the conventional Chinese medicine of the treatment of sexual dysfunction has following:

1. the immunologic function of body is improved.Wherein the immunologic function of body comprises cellular immunization and the large class of immunity of organism two.

2. endocrine regulation function is improved.Most of deficient syndrome patient, often visible endocrine gland degeneration or atrophy on pathomorphism, antepituitary, adrenal cortex, thyroid, testis or ovary all present degeneration change in various degree.Also can there is atrophy, degeneration in other histiocytes, this is organ, organizes incompetent material base.

3. hemopoietic function of bone marrow is improved.Be main treatment chronic aplastic anemia with Kidney-Nourishing, curative effect significantly improves.

4. the substance metabolism of body is improved.Promote the biosynthesis of protein, DNA, RNA, improve the activity of RNA polymerase, improve serum albumin synthetic ratio, improve albumin and r-globulin content, promote the division of medullary cell, make erythrocyte, trend that leukocyte has rising.

5. strengthen anti-stress ability, regulating YIN and YANG balances.Many tonifying YANG Chinese medicines can improve the adaptability of body, and enhancing body, to the non-specific resistivity of various destructive stimulus, makes disorderly functional recovery normal.

6. regulating microelement.Research proves, trace element has many important physiological functions (as relevant to sexual function) and biological action, plays extremely important effect in human life activity and metabolic process.

From ancient times to the present, the traditional Chinese medical science just record of targeted dysfunction treatment and discussion.Treatment by Chinese herbs comprises and has tonifying YANG effect or the handicapped prescriptions of Chinese medicine of treatability, and its common method has Kidney-Nourishing, activating blood and removing stasis Method, method of dissipating heat and detoxifying etc.

Now, still have many traditional Chinese medical science for the research for the treatment of of sexual dysfunctions, from prescription, preparation, each side such as clinical further investigation, and bear the prescriptions of Chinese medicine emerged in an endless stream accordingly, and applied for Patents.

Prescription of the present invention is the secret prescription handed down in the family from generation to generation prepared by " YUNNAN BAIYAO " founder Qu Huanzhang, after arrange preparation by its sub-Qu Jiarui, according to the cure mechanism of above Chinese medicine, in conjunction with for mechanism treatment in conventional Chinese medicine, according to monarch, minister, help, make principles of formulating prescriptions reasonable compatibility and obtain, then improve improvement further by bent family descendant and obtain prescription of the present invention.

Qu Huanzhang (1880 ~ 1938), YUNNAN BAIYAO founder, the famous doctor of Republic traditional Chinese medical science external wounds, duty asks the much traumatology good medicine of local doctor among the people, good recipe, do painstaking research test, develops traumatology panacea cure-all (i.e. YUNNAN BAIYAO) in 1902.Nineteen twenty-seven, successfully have developed the refining BAIYAO of " the red son of a medicine three " (common BAIYAO is red, heavily rises cure-all, three liters of cure-alls and insurance).The reputation of YUNNAN BAIYAO, moves towards the ground such as port, Australia, Singapore, Jakarta, Rangoon, Bangkok, Japan by domestic.1938, Qu Huanzhang was access to Chongqing by Kuomintang, and because refusal offers BAIYAO secret recipe, August in the same year is killed.In February, 1956, after liberation, Qu Huanzhang widow Miao Lanying has dedicated new China to BAIYAO secret recipe, is produced by Kunming pharmaceutical factory, and Qu Shi BAIYAO is renamed as " YUNNAN BAIYAO " in the whole nation.

The son of Qu Jiarui, YUNNAN BAIYAO contriver Qu Huanzhang, uniquely to pass on a skill of craft to others.The pharmacy history of practising medicine of many decades, in the process of the various difficult miscellaneous diseases for the treatment of, constantly explores the practical application of secret prescription handed down in the family from generation to generation.Explore the Particular craft of good medicine of curing the disease, once medical treatment, R&D institution's tenure, Zeng Ren Yunnan Baiyao Plant vice factory director, Kunming pharmaceutical factory of traditional Chinese medicine factory director, chief engineer.1985, take wife's belt and carry out Sanming, Fujian Province development, government of Fujian Province, Sanming City government attached the importance cares, settle down Sanming City, establishment Sanming City pharmaceutical factory of traditional Chinese medicine (being incorporated to state-run factory afterwards).Mr. Qu Jiarui is contemporary Chinese medicine circle famous person, and Development Research Center of the State Council awards with epoch personage title, is the development person of multiple new drug.In January, 2002 is due to illness dead.Its wife Li Rong peak is taken son and is held unfulfilled wish altogether, continues Developing TCM cause.Qu Luoyun, Qu Luokun, Qu Luomin are that the children of Qu Jiarui are all an apprentice of father from little, have the experience of years of work in pharmacy corporation, R&D institution, medical institutions.Under the care of Sanming City relevant department helps, within 2005, establish the pharmacy spirit of Qu Jiarui (Sanming City) Chinese medicine study institute development based on inheritance ancestors, work hard to complete the long-cherished wish that elder generation are unfinished, secret recipe handed down from one's ancestors for Qu Shi is continually developed, offer as a tribute society.

Prescription of the present invention has certain historical origin, is originally prepared by " YUNNAN BAIYAO " founder Qu Huanzhang and is supplied to the health product of Yunnan governor specially, however prescription at that time wherein to include Pericarpium Papaveris, Penis et testis Tigris etc. valuable or forbid medical material.After liberation, improved on original prescription basis by the sub-Qu Jiarui of Qu Huanzhang, abandon valuable with forbid medical material Penis et testis Tigris and Pericarpium Papaveris etc., ins conjunction with process conditions at that time, final formation is easy to obtained prescription and prescription of the present invention.

Summary of the invention

The object of this invention is to provide a kind of prescription of compound Chinese medicinal preparation with kidney invigorating and YANG supporting, the treatment of sexual dysfunction, slow down aging.

Wherein include in this prescription: Cornu Cervi Pantotrichum, Radix Ginseng, Hippocampus, Radix Morindae Officinalis, Herba Epimedii, Rhizoma Curculiginis, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, Herba Cistanches, Testis et Pentis Canis, Fructus Lycii, Radix Polygoni Multiflori Preparata be totally ten three taste Chinese medicines.

This prescription according to monarch, minister, help, make principles of formulating prescriptions reasonable compatibility, get kidney-Yang invigorating, the Cornu Cervi Pantotrichum of beneficial marrow, the Radix Ginseng of strongly invigorating primordial QI are monarch drug altogether, and QI invigorating tonifying YANG, fills up marrow; Get the Hippocampus of kidney invigorating and YANG supporting, Radix Morindae Officinalis, the Herba Epimedii of invigorating kidney-YANG, the Rhizoma Curculiginis of the kidney warming sun, Fructus Cnidii, warming middle-JIAO Yiyang Semen Allii Tuberosi be ministerial drug, to increase main kidney invigorating and YANG supporting effect; Get the Semen Cuscutae of the kidney invigorating and essence nourishing, Herba Cistanches, Testis et Pentis Canis, the Fructus Lycii of Yin-nourishing and Yang-supporting, the Radix Polygoni Multiflori Preparata of kidney tonifying tonifying liver be adjuvant drug, kind YANG invigorating person must give treating YANG within YIN, to help principal agent life essence-filling, marrow-benefitting.In addition, Radix Polygoni Multiflori Preparata can also play effect of pathogenic fire reducing, prevents other taste Chinese medicines of this prescription from causing the side effect of getting angry.

The invention provides a kind of compound Chinese medicinal preparation, is that crude drug is prepared from the Chinese medicine of following weight proportion:

Title	Number	Title	Number	Title	Number
						Cornu Cervi Pantotrichum	0-1 part	Radix Ginseng	0-5 part	Hippocampus	0-5 part
Radix Morindae Officinalis	0-50 part	Herba Epimedii	0-40 part	Rhizoma Curculiginis	0-50 part
						Fructus Cnidii	0-20 part	Semen Allii Tuberosi	0-50 part	Herba Cistanches	0-50 part
Semen Cuscutae	0-40 part	Testis et Pentis Canis	0-20 part	Fructus Lycii	0-50 part
						Radix Polygoni Multiflori Preparata	0-60 part	Microcrystalline Cellulose	0-10 part	Magnesium stearate	0-5 part

Compound Chinese medicinal preparation of the present invention, if preferred employing gram is unit of weight, is that crude drug is prepared from the Chinese medicine of following weight proportion:

Title	Weight	Title	Weight	Title	Weight
						Cornu Cervi Pantotrichum	100-150g	Radix Ginseng	400-600g	Hippocampus	400-600g
Radix Morindae Officinalis	4000-6000g	Herba Epimedii	4000-5000g	Rhizoma Curculiginis	4000-6000g
						Fructus Cnidii	1500-2000g	Semen Allii Tuberosi	4000-6000g	Herba Cistanches	4000-6000g
Semen Cuscutae	3000-4000g	Testis et Pentis Canis	1200-1600g	Fructus Lycii	4000-6000g
						Radix Polygoni Multiflori Preparata	5000-7000g

Compound Chinese medicinal preparation of the present invention, if most preferred employing gram is unit of weight, is that crude drug is prepared from the Chinese medicine of following weight proportion:

Title	Weight	Title	Weight	Title	Weight
						Cornu Cervi Pantotrichum	120g	Radix Ginseng	500g	Hippocampus	500g
Radix Morindae Officinalis	5000g	Herba Epimedii	3500g	Rhizoma Curculiginis	5000g
						Fructus Cnidii	1800g	Semen Allii Tuberosi	5000g	Herba Cistanches	5000g
Semen Cuscutae	3500g	Testis et Pentis Canis	1500g	Fructus Lycii	5000g
						Radix Polygoni Multiflori Preparata	6000g

More than in composition, the weight of each taste medicine calculates with crude drug, can increase according to corresponding proportion when producing or reduce, as large-scale production can by kilogram in units of, or in units of ton, small-scale production also can by gram or milligram in units of, weight can increase or reduce, but the constant rate of raw medicinal herbs weight proportion between each composition.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is constant.

Chinese medicine preparation of the present invention, being that the raw material of Chinese medicine medical material by being formed by above-mentioned formula is processed through extraction or other modes, making pharmaceutically active substance, subsequently, with this material for raw material, when needing, add medicine acceptable carrier, make according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can be obtained by the common raw material of Chinese medicine medical material that extracts, also can obtain by other means, as: by pulverizing, squeezing, grind, sieve, the material that method obtains, these active substances can be extractum form such as percolation, extraction, water extraction, alcohol extraction, ester carry, chromatography, can be dry extract also can be fluid extract, need to determine to make different concentration according to the difference of preparation.

Pharmaceutical preparation of the present invention, the preferably pharmaceutical dosage forms of unit dose, can make any pharmaceutically useful dosage form when making pharmaceutical preparation, these dosage forms are selected from: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, pill, powder, unguentum, sublimed preparation, suspensoid, solution, injection, suppository, ointment, plaster, cream, spray, patch.Preferably oral dosage form, most preferably capsule, granule.

Pharmaceutical preparation of the present invention, can add some medicine acceptable carriers as required, and galenic pharmacy routine techniques can be adopted to prepare this pharmaceutical preparation, as mixed with medicine acceptable carrier by pharmaceutically active substance.The acceptable carrier of described medicine is selected from: mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, vitamin E, vitamin D, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, soil temperature 60-80, span-80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, agar, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.

Pharmaceutical preparation of the present invention is in use according to the situation determination usage and dosage of patient.

Chinese medicine preparation of the present invention, when making medicament, the medicament of unit dose can contain pharmaceutically active substance 0.1-1000mg of the present invention, and all the other are pharmaceutically acceptable carrier.Pharmaceutically acceptable carrier can be the 0.1-99.9% of total formulation weight amount by weight.

Pharmaceutical preparation of the present invention, its pharmaceutically active substance is through that to extract processing obtained, as following processing method:

Its preparation method, its step is as follows:

1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, filters, is concentrated into appropriate extractum I for subsequent use;

2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate extractum II, for subsequent use;

3) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is concentrated into appropriate extractum III, for subsequent use.

4) after above-mentioned I ~ III extractum concentrated solution all being merged mix homogeneously with 90% ethanol, reconcentration is to smart paste; load in stainless steel disc; dry 48 hours of 50 ~ 60 DEG C of reduced vacuum in vacuum drying oven, rear taking-up is poured in granulator to granulate and is weighed, and obtains granule for subsequent use.

5) get microcrystalline Cellulose, magnesium stearate, pulverize with high speed disintegrator and cross 100 mesh sieves, in 100 DEG C of drying under reduced pressure more than 10 hours, be chilled to room temperature for subsequent use.

6) mix with the adjuvant of 5 steps according to the granule of prescription ratio by 4 step gained, pour mixer Homogeneous phase mixing after mixing into 1 hour, rear taking-up is distributed into the preparation of respective numbers, target product.

Below by way of experimental data, beneficial effect of the present invention is described.

The object of this invention is to provide the clinical practice in all fields of this compound Chinese medicinal preparation.

The preparation obtained according to above-mentioned prescription, its major function has: strengthening and nourishing marrow and essence, strong Yuanyang, slow down aging, improves body's immunity and nervous physiology respond, the effects such as improvement hypofunction.Be applicable to the empty or ageing patients of body of kidney qi weakness, the clinical witness of decline of kidney-YANG, be also applicable to the prime of life fleshlinesss, geromorphism, lethargy, waist knee joint is weak, nocturia increases, have a dizzy spell, tinnitus, seminal emission premature ejaculation, Yuanyang thanks to and hyposexuality person.Wherein it is specifically intended that heart disease hypertension severe one forbidding; This effect is invalid to prostate patient.

For better describing the application clinically of the above-mentioned preparation of the present invention, corresponding clinical indication is as follows:

1, building body.To soreness of the waist and knees, extremity fear of cold, nocturia, insomnia and dreamful sleep, dizziness and tinnitus, spontaneous sweating, sensation of oppression over the chest with shortness of breath, emaciation and sallow complexion, inappetence, the diseases such as lethargy have special effect.

2, the kidney invigorating and essence nourishing.To the impotence erectile problem caused by insufficiency of kidney-YANG, spermatorrhea premature ejaculation; It is continuous that women leucorrhea drenches drop, and cold womb is infertile, and menoxenia and hyposexuality person have definite curative effect.

3, cardio and vascular function is improved.Strengthen myocardial contraction, blood vessel dilating, blood fat reducing, improves microcirculation, arrhythmia and the effect such as anti-cardiac muscle and cerebral anoxia.

4, remarkable slow down aging.Improve SOD active, remove LPO free radical, effectively reduce infirmities of age and occur.

5, comprehensive enhancing human body immunity function, increases leukocyte count, prevents and treats the leukocyte count minimizing that various disease causes.

6, improve nervous physiology respond, quick allaying tiredness, accelerate antisecosis, stamina intensifying and explosive force, strengthening the tendons and bones.

For further describing preparation application clinically, with the sample in embodiment 1, according to every twice-daily, each 1, taking 30 days is a course for the treatment of, has following clinical data:

1, kidney qi deficient syndrome

1) curative effect

Group	Number of cases	Effective routine %	Effective routine %	Invalid routine %	Total effective rate %
						Expansion group	13	7(53.85％)	6(46.15％)	0(0％)	100％

2) change for the treatment of front and back integration

Group	Number of cases	Before treatment	After treatment	Front and back difference	P
						Expansion group	13	17.1±13.56	5.55±5.52	11.55±9.15	<0.01

2, deficiency of kidney-YANG syndrome

1) curative effect

Group	Number of cases	Effective routine %	Effective routine %	Invalid routine %	Total effective rate %
						Expansion group	7	3(42.86％)	3(42.86％)	1(14.28％)	85.71％

2) change for the treatment of front and back integration

Group	Number of cases	Before treatment	After treatment	Front and back difference	P
						Expansion group	7	29.85±5.55	13.42±7.13	16.42±6.77	<0.01

3, hyposexuality symptom

1) curative effect

Group	Number of cases	Effective routine %	Effective routine %	Invalid routine %	Total effective rate %
						Expansion group	17	8(47.06％)	7(41.18％)	2(11.76％)	88.24％

4, old and feeble disease

1) curative effect

Group	Number of cases	Effective routine %	Effective routine %	Invalid routine %	Total effective rate %
						Expansion group	20	10(50％)	9(45％)	1(5％)	95％

2) change for the treatment of front and back integration

Group	Number of cases	Before treatment	After treatment	Front and back difference	P
						Expansion group	20	18.2±5.17	6.9±3.96	11.3±3.52	<0.01

5, analysis of adverse reactions

Occur xerostomia phenomenon once in a while in drug administration process, remaining without obvious adverse reaction, before and after above-mentioned example treatment, routine blood test, routine urianlysis have no abnormal changes.

To sum up, compound Chinese medicinal preparation of the present invention has the following advantages clinically:

1, toxic and side effects is little, edible safety, not easily gets angry;

2, clinical practice is extensive, and unisex, drug effect is obvious.

Separately have multiple case as follows:

Case 1: Liu * *, male, 57 years old, first visit soreness of the waist and knees, lassitude and weak, spontaneous perspiration, hyposexuality, pale tongue is fat, thready and weak pulse, Chinese medical discrimination is kidney qi deficient syndrome, and controlling pronephridiostome qi deficiency integration is 24 points, and the old and feeble disease integration of the traditional Chinese medical science is 30 points, blood LPO:5.6nmol/ml, TSOD 40.2u, MnSOD 72u, CuZn SOD32.2u, CD ₃50%, CD ₄29%, CD ₈20%.LH:13.7MIu/ml, FSH:28.9MIu/ml, through giving the embodiment of the present invention 1 capsule, each 1, every twice-daily, takes 30 days continuously.Control metanephros qi deficiency integration and be only 4 points, the old and feeble disease integration of the traditional Chinese medical science is 9 points, blood LPO:2.2nmol/ml, TSOD 43u, MnSOD10u, CuZn SOD 35.1u, CD ₃56%, CD ₄32%, CD ₈25%.LH:6.7MIu/ml, FSH:13.1MIu/ml, clinical symptoms is obviously improved.

Case 2: Soviet Union * *, male, 52 years old, first visit asthenia facial edema, soreness of the waist and knees, aversion to cold and cold limbs, forgetful, hyposexuality, light red tongue is fat and moisten, tongue is thick in vain, deep-slow pulse, Chinese medical discrimination is deficiency of kidney-YANG syndrome, and controlling front deficiency of kidney-YANG syndrome integration is 21 points, the old and feeble disease integration of the traditional Chinese medical science is 27 points, blood LPO:5.2nmol/ml, TSOD 41.2u, MnSOD8.0u, CuZn SOD 29u, CD ₃54%, CD ₄32%, CD ₈23%.LH:10.7MIu/ml, FSH:21.3MIu/ml, through giving the embodiment of the present invention 1 capsule, each 1, every twice-daily, takes 30 days continuously.Control rear deficiency of kidney-YANG syndrome integration and be only 5 points, the old and feeble disease integration of the traditional Chinese medical science is 7 points, blood LPO:1.9nmol/ml, TSOD45u, MnSOD 11u, CuZn SOD 34u, CD ₃58%, CD ₄38%, CD ₈30%.LH:5.3MIu/ml, FSH:11.2MIu/ml, libido strengthens, and clinical symptoms is improved.

Case 3: Ruan * *, women, 59 years old, the symptoms such as spiritlessness and weakness, soreness of the waist and knees, spontaneous perspiration, hyposexuality of paying a home visit, Chinese medical discrimination was deficiency of kidney-QI 24 points, and the old and feeble disease integration of the traditional Chinese medical science is 28 points.Give the embodiment of the present invention 1 capsule, each 1, every twice-daily, takes 30 days continuously.Control rear deficiency of kidney-QI integration and only have 8 points, the old and feeble disease integration 6 points of the traditional Chinese medical science, clinical symptoms is obviously improved.

In sum, Chinese medicine preparation prescription of the present invention has the following advantages in prescription, technique:

1, prescription medical material is all easy to get, and collocation rationally, not easily gets angry;

2, processing procedure is simple to operation, without the need to special installation, is applicable to amplifying commercial production;

3, multi-flavor medicine can process simultaneously, without the need to processing every taste prescription one, saves operation;

4, concocting process single solvent ethanol, recycling capable of circulation, reduces environmental protection and production cost;

5, whole processing procedure meets the requirement of modernization process, can produce the product that quality is secure.

Detailed description of the invention

Further illustrate the present invention below by several specific embodiment, the concrete data related to and operation etc. are not formed to the restriction of application claims protection domain in embodiment.

Embodiment 1 (capsule)

Prescription:

Title

Weight

Title

Weight

Title

Weight

Cornu Cervi Pantotrichum	12g	Radix Ginseng	50g	Hippocampus	50g
						Radix Morindae Officinalis	500g	Herba Epimedii	350g	Rhizoma Curculiginis	500g
Fructus Cnidii	180g	Semen Allii Tuberosi	500g	Herba Cistanches	500g
						Semen Cuscutae	350g	Testis et Pentis Canis	150g	Fructus Lycii	500g
Radix Polygoni Multiflori Preparata	600g	Microcrystalline Cellulose	80g	Magnesium stearate	20g

1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, filters, is concentrated into appropriate extractum I for subsequent use;

2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate extractum II, for subsequent use;

3) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is concentrated into appropriate extractum III, for subsequent use.

4) after above-mentioned I ~ III extractum concentrated solution all being merged mix homogeneously with 90% ethanol, reconcentration is to smart paste; load in stainless steel disc; dry 48 hours of 50 ~ 60 DEG C of reduced vacuum in vacuum drying oven, rear taking-up is poured in granulator to granulate and is weighed, and obtains granule for subsequent use.

5) get microcrystalline Cellulose, magnesium stearate, pulverize with high speed disintegrator and cross 100 mesh sieves, in 100 DEG C of drying under reduced pressure more than 10 hours, be chilled to room temperature for subsequent use.

6) mix with the adjuvant of 5 steps according to the granule of prescription ratio by 4 step gained, pour mixer Homogeneous phase mixing into 1 hour after mixing, rear taking-up is distributed into the capsule 1000 of respective numbers.

Instructions of taking: oral every day secondary, each one.

Embodiment 2 (tablet)

Prescription: with embodiment 1

1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, filters, is concentrated into appropriate extractum I for subsequent use;

2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate extractum II, for subsequent use;

3) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is concentrated into appropriate extractum III, for subsequent use.

4) after above-mentioned I ~ III extractum concentrated solution all being merged mix homogeneously with 90% ethanol, reconcentration is to smart paste; load in stainless steel disc; dry 48 hours of 50 ~ 60 DEG C of reduced vacuum in vacuum drying oven, rear taking-up is poured in granulator to granulate and is weighed, and obtains granule for subsequent use.

5) get microcrystalline Cellulose, magnesium stearate, pulverize with high speed disintegrator and cross 100 mesh sieves, in 100 DEG C of drying under reduced pressure more than 10 hours, be chilled to room temperature for subsequent use.

6) mix with the adjuvant of 5 steps according to the granule of prescription ratio by 4 step gained, pour mixer Homogeneous phase mixing into 1 hour after mixing, tabletting obtains 1000, tablet.

Instructions of taking: oral every day secondary, each a slice.

Embodiment 3 (capsule)

Prescription:

Title	Weight	Title	Weight	Title	Weight
						Cornu Cervi Pantotrichum	12g	Radix Ginseng	50g	Hippocampus	50g
Radix Morindae Officinalis	250g	Herba Epimedii	200g	Rhizoma Curculiginis	200g
						Fructus Cnidii	180g	Semen Allii Tuberosi	500g	Herba Cistanches	250g
Semen Cuscutae	350g	Testis et Pentis Canis	150g	Fructus Lycii	500g
						Radix Polygoni Multiflori Preparata	500g	Microcrystalline Cellulose	80g	Magnesium stearate	20g

Method for making: with embodiment 1.

Instructions of taking: oral every day three times, each one.

Embodiment 4 (granule)

Prescription:

Title	Weight	Title	Weight	Title	Weight
						Cornu Cervi Pantotrichum	12g	Radix Ginseng	50g	Hippocampus	50g
Radix Morindae Officinalis	250g	Herba Epimedii	200g	Rhizoma Curculiginis	200g

Fructus Cnidii	180g	Semen Allii Tuberosi	500g	Herba Cistanches	250g
						Semen Cuscutae	350g	Testis et Pentis Canis	150g	Fructus Lycii	500g
Radix Polygoni Multiflori Preparata	500g

1) get Radix Polygoni Multiflori Preparata, Radix Morindae Officinalis, Rhizoma Curculiginis, Fructus Lycii, Herba Epimedii, Fructus Cnidii, Semen Allii Tuberosi, Semen Cuscutae, the clean medicine of Herba Cistanches nine taste, add 70-80% ethanol submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution; Residue adds 70-80% ethanol, extracts once with method, merges secondary raffinate, is concentrated into appropriate, and concentrated solution adds the long-pending water precipitation of diploid, filters, is concentrated into appropriate extractum I for subsequent use;

2) get Hippocampus, Cornu Cervi Pantotrichum, the mixing of Testis et Pentis Canis three taste, be ground into coarse powder, add ethanol to submergence medical material, be heated to 80 DEG C, insulation dipping 2 hours, divides and gets extracting solution, and residue adds ethanol and extracts once with method, merges secondary raffinate, is concentrated into appropriate extractum II, for subsequent use;

3) get Radix Ginseng powder, add soak with ethanol 24 hours, filter, collect filtrate, residue added 50% soak with ethanol after 4 hours, then refluxed 2 hours, and filter, residue adds 50% ethanol again, and extract once with method, merge extractive liquid, is concentrated into appropriate extractum III, for subsequent use.

4) after above-mentioned I ~ III extractum concentrated solution all being merged mix homogeneously with 90% ethanol, reconcentration is to smart paste; load in stainless steel disc; dry 48 hours of 50 ~ 60 DEG C of reduced vacuum in vacuum drying oven, rear taking-up is poured in granulator to granulate and is weighed, and obtains granule for subsequent use.

5) get microcrystalline Cellulose, magnesium stearate, pulverize with high speed disintegrator and cross 100 mesh sieves, in 100 DEG C of drying under reduced pressure more than 10 hours, be chilled to room temperature for subsequent use.

6) mix with the adjuvant of 5 steps according to the granule of prescription ratio by 4 step gained, pour mixer Homogeneous phase mixing after mixing into 1 hour, be distributed into granule.

Instructions of taking: taken with boiled water once a day, each one bag.

Embodiment 5 (capsule)

Title	Weight	Title	Weight	Title	Weight
						Cornu Cervi Pantotrichum	100g	Radix Ginseng	400g	Hippocampus	400g
Radix Morindae Officinalis	4000g	Herba Epimedii	4000g	Rhizoma Curculiginis	4000g
						Fructus Cnidii	1500g	Semen Allii Tuberosi	4000g	Herba Cistanches	4000g
Semen Cuscutae	3000g	Testis et Pentis Canis	1200g	Fructus Lycii	4000g
						Radix Polygoni Multiflori Preparata	5000g

Method for making: with embodiment 1, is prepared into 10000.

Instructions of taking: oral every day three times, each one.

Embodiment 6 (capsule)

Title	Weight	Title	Weight	Title	Weight
						Cornu Cervi Pantotrichum	150g	Radix Ginseng	600g	Hippocampus	600g
Radix Morindae Officinalis	6000g	Herba Epimedii	5000g	Rhizoma Curculiginis	6000g
						Fructus Cnidii	2000g	Semen Allii Tuberosi	6000g	Herba Cistanches	6000g
Semen Cuscutae	4000g	Testis et Pentis Canis	1600g	Fructus Lycii	6000g
						Radix Polygoni Multiflori Preparata	7000g

Method for making: with embodiment 1, is prepared into 10000.

Instructions of taking: oral every day three times, each one.

Claims (6)

1. a compound Chinese medicinal preparation is preparing strengthening and nourishing marrow and essence, strong Yuanyang, slow down aging, improve body's immunity and nervous physiology respond, application in the medicine of improvement hypofunction, described compound Chinese medicinal preparation is that crude drug is prepared from the Chinese medicine of following weight proportion:

。

2. application according to claim 1, wherein said compound Chinese medicinal preparation is that crude drug is prepared from the Chinese medicine of following weight proportion:

3. application according to claim 1, compound Chinese medicinal preparation is wherein that crude drug is prepared from the Chinese medicine of following weight proportion:

。

4. application according to claim 1, comprises 1) building body; 2) the kidney invigorating and essence nourishing; 3) cardio and vascular function is improved.

5. application according to claim 1, comprises the body void for kidney qi weakness, the clinical witness of decline of kidney-YANG or ageing patients.

6. application according to claim 1, comprises for prime of life fleshliness, geromorphism, lethargy, waist knee joint is weak, nocturia increases, has a dizzy spell, tinnitus, seminal emission premature ejaculation, Yuanyang lost and hyposexuality person.