CN106031418A - Composition having physical power fatigue releasing function, and preparation method thereof - Google Patents
Composition having physical power fatigue releasing function, and preparation method thereof Download PDFInfo
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- CN106031418A CN106031418A CN201510115278.8A CN201510115278A CN106031418A CN 106031418 A CN106031418 A CN 106031418A CN 201510115278 A CN201510115278 A CN 201510115278A CN 106031418 A CN106031418 A CN 106031418A
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Abstract
The present invention discloses a composition having a physical power fatigue releasing function, and a preparation method thereof. The composition is prepared from ginseng, cornu cervi pantotrichum, chinese wolfberry, gastrodia elata, and eucommia ulmoides according to a certain weight ratio, and can be prepared into any one of commonly used preparations, preferably oral preparations. The composition of the present invention has the physical power fatigue releasing function.
Description
Technical field
The present invention relates to a kind of compositions with function of physical fatigue alleviation and preparation method thereof, belong to health care
The technical field of food.
Background technology
Fatigue is the physiological acoustic signals process of body load.The 5th international movement biochemistry meeting pair of nineteen eighty-two
The definition of tired concept is: " its technical ability can not be continued at a specified level or each organ by organism physiology process
Its predetermined exercise intensity can not be maintained.”
Modern medicine thinks that fatigue is that body crosses use (transfiniting) and the function that causes reduces and the shape of discomfort occurs
State, mainly shows as tired sleepy, may occur in which degradation simultaneous phenomenon under dizziness, forgetful, sleep quality.Tired
The generation of labor and energy substance consumption, metabolite accumulation, homeostasis sexual maladjustment, free radical impact etc.
Factor relation is close.Cause reason generally speaking can be summarized as: 1. energy substance consumes excessively, as ATP, CP,
Muscle glycogen and hepatic glycogen consume excessively；2. fatigue substances is piled up in vivo, and lactic acid and protein breakdown products are big
Amount remains in internal；The disorder of interior environment, except lactic acid pile up in addition to, body osmotic pressure, ion distribution,
Changes in environmental conditions in pH, moisture, temperature etc., makes body acid-base balance, Osmotic balance, water balance lack of proper care,
Ability to work is caused to decline and fatigue occurs；4. nervous system, enzyme, hormone are to metabolic regulation imbalance during motion
Deng.
" tired " belongs to the categories such as the traditional Chinese medical science " empty ", " asthenia ", " deficient ", in Huangdi's Internal Classics,
Tired many referred to as " tired ", " lassitude and weariness ", " tired thin ", " heavy sensation of the body ", " body weight " etc.." Plain Questions. show a calm opinion piece "
In point out " deficiency of the liver, suffer from a deficiency of the kidney insufficiency of the spleen, all make us body weight feeling of restlessness and irritation ", according to the traditional Chinese medical science theory of visceral outward manifestation, tired and the five internal organs
All be related, main duty in spleen, liver, kidney, also relevant with the heart, lung.Tired generation and gas, blood,
The loss of yin, yang has close relationship.It addition, in motor process, Qi, sweating Qi, impairment of body fluid consumption liquid, easily
Cause YIN-fluid being insufficient, it is seen that fatigue also wasting QI-blood body fluid.In a word, the traditional Chinese medical science thinks tired mainly by various former
Because causing spleen, liver, the dirty dysfunction of kidney three, the heart, lung are caused by involving negative and positive of qi and blood imbalance.
Along with raising and the enhancing of people's health consciousness of Levels of Social Economic Development, people recognize more and more
Knowing the importance to alleviating physical fatigue, the product of alleviating physical fatigue receives people's the most more and more
Pay close attention to.The mankind re-recognize for health so that the theory of " diseases prevention be better than cure the disease " is rooted in the hearts of the people, and protect
The advantage that health food can be taken with long-term safety with it, firmly gets the approval of people.Thus, exploitation has alleviation
The product of physical fatigue function has wide market prospect.
Summary of the invention
It is an object of the present invention to provide a kind of compositions with function of physical fatigue alleviation.
Another object of the present invention there is provided the preparation method of said composition.
The present invention is achieved by the following technical solutions:
The present invention is made up of the raw material of following weight parts:
Radix Ginseng 5-30 part, cervus elaphus linnaeus 1-15 part, Fructus Lycii 10-50 part, Rhizoma Gastrodiae 10-50 part, Cortex Eucommiae 10-50
Part.
It is preferably:
Radix Ginseng 10-20 part, cervus elaphus linnaeus 3-8 part, Fructus Lycii 25-35 part, Rhizoma Gastrodiae 25-35 part, Cortex Eucommiae 25-35
Part.
More preferably:
Radix Ginseng 15 parts, cervus elaphus linnaeus 5 parts, Fructus Lycii 30 parts, 30 parts of Rhizoma Gastrodiae, the Cortex Eucommiae 30 parts.
The present invention relates to a kind of compositions, it is on the basis of existing theory of Chinese medical science, and filtering out can be the most slow
The prescription of physical fatigue, carries out scientific compatibility, plays its mutual synergism, thus obtains one and have
The formula of function of physical fatigue alleviation.
In the present invention, the mechanism of action of each component is as follows:
Radix Ginseng: for the dry root and rhizome of Araliaceae Radix Ginseng.Property hardship sweet, micro-, flat, return spleen, lung,
Heart channel.Having strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, the effect calmed the nerves.It is intended to for body void
Taking off, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear
Insomnia, sexual impotence cold womb；Heart failure, cardiogenic shock.Modern study shows, in Radix Ginseng containing saponins,
Saccharide, volatile ingredient, organic acid and ester thereof, several amino acids, protein, enzyme, sterol and glycosides thereof,
Many peptides, nitrogen-containing compound, lignin, flavonoid, vitamins, inorganic elements etc..There is nourishing strong
Strengthen, improve muscle power and mental work ability, reduce fatigue, regulate the effect of central nervous system.Radix Ginseng can
Improve thinking and body activities ability, not only can strengthen neural excitation, also can strengthen its suppression
Process, makes suppression tend to concentrating, and differentiation is complete so that excitement and two kinds of nervous process of suppression are balanced,
Improve intelligence and the labor efficiency of muscle power of people.It is proved panaxoside Rg1Effect is notable, to old rats abdomen
Chamber injection 20,40mg/kg panaxoside Rg110d continuously, finds to walk number of times between rat grid secondary with upright
Number substantially increases, and result points out it can improve the mobility of older animals decline.Utilize Radix Ginseng extractive solution couple
Endurance is studied, and experimental result finds that Radix Ginseng extractive solution can significantly extend the mice burden swimming time,
Continuing swimming time and averagely extend 31.84% than matched group, persistently swimming maximum duration averagely improves 7.93min；
Swimming time averagely extends 30.64% than matched group, and power exhausts swimming maximum duration and averagely improves than matched group
7.27%.Illustrate that Radix Ginseng can improve endurance and motor capacity, reduce nervus centralis fatigue reaction.
Cervus elaphus linnaeus: for the unossified close raw young pilose antler of stag of animal in deer family Cervus elaphus linnaeus Cervus elaphus Linnaeus
The processed product of the young horn of hair.Cornu Cervi Pantotrichum is warm in nature, sweet-salty.Return liver, kidney two warp.Qi-restoratives is thin for tool, strengthening bone and muscle,
Spermatogenesis mends marrow, the effect in Yiyang of nourishing blood.Clinical pharmacology confirms, Cornu Cervi Pantotrichum can improve the ability to work of body,
Improve sleep and appetite, to asthenia universalis, the patient after prolonged illness, present good rejuvenation effect.China
In ancient medicine books, early have Cornu Cervi Pantotrichum can " the strong will of QI invigorating ", mend " foot knee joint is unable ", have " spermatogenesis mend marrow,
Strong muscles and bones " etc. the description of effect.Reflect that Cornu Cervi Pantotrichum is early used in the rejuvenation aspect of body.This with modern age pharmacology
The research learned is the most close.Antler polypeptide (PAP) can dramatically increase mice normobaric hypoxia time-to-live, broken end
Breathing time, pole-climbing time and walking weight load；And the increments of serum lactic after swimming can be significantly reduced.
Illustrate that PAP can improve the ability of mice anoxia enduring and resisting fatigue.
Fructus Lycii: for the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Nature and flavor
Sweet, flat, return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.Cure mainly asthenia damage of essence, soreness of waist and knee joint, dizziness
Tinnitus, interior-heat quenches one's thirst, blood deficiency and yellow complexion, and blurred vision is not clear waits disease.Modern pharmacology research confirms that Fructus Lycii has
Regulation immunity of organism, anti-fatigue effect, it addition, Fructus Lycii can also effectively suppress tumor growth and cell mutation,
There is the effect of the aspects such as slow down aging.The mechanism of Fructus Lycii resisting fatigue is: Fructus Lycii can dramatically increase inose
Former, the stockage of hepatic glycogen, improves human activity, and has the effect of resisting fatigue.
Rhizoma Gastrodiae: for the dry tuber of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Nature and flavor are sweet, flat, return
Liver Channel, suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.For infantile convulsion, epilepsy clonus, tetanus, dizziness of having a headache, limbs fiber crops
Wood, rheumatic arthralgia.Shennong's Herbal is classified as Rhizoma Gastrodiae top grade, and Compendium of Material Medica records Rhizoma Gastrodiae can be " main
All migratory arthralgia, take QI invigorating for a long time, make light of one's life by commiting suicide all the year round ", medicinal history is long, for tradition rare Chinese medicine.Rhizoma Gastrodiae contains
Gastrodine, gastrodia elata genin (p-Hydroxybenzylalcohol), gastrodia elata polysaccharide, hydroxy benzaldehyde, citric acid, Fructus Citri Limoniae
Acid mono-methyl, sitosterol etc., its modern study shows that Rhizoma Gastrodiae has calmness, hypnosis, convulsion, improves machine
Body immunity, anti peroxidation of lipid, improves the pharmacological actions such as memory.
The Cortex Eucommiae: for the dry bark of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv..Nature and flavor are sweet,
Temperature, returns Liver and kidney warp, invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.For deficiency of the liver and kindey, soreness of waist and knee joint, muscles and bones is unable,
Have a dizzy spell, blood leaking in gestation, frequent fetal movement.Result of study shows both at home and abroad, and the pharmacological action of the Cortex Eucommiae mainly has:
Blood pressure lowering, regulates blood fat, blood sugar lowering, enhancing immunity, anticancer, press down cancer, and blood fat reducing suppression cholesterol rises,
Mutation, anticomplementary activity, antioxidation, preventing bone rarefaction, promote skeleton machine matter metabolism, resisting fatigue
With wound healing effect.
Instant component can use the conventional method of Chinese medicine preparation to be prepared as the preparation of any routine, including mouth
Formulation, external preparation, injection etc..These crude drug such as can be ground into powder mix homogeneously；Can
To be added water respectively by the crude drug of described weight portion or the ethanol extraction of variable concentrations, extracting solution concentrate drying obtains
Crude extract, or use process for purification, such as, decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography,
Carbon dioxide supercritical extraction method, steam distillation carry out being refining to obtain extract.
When using said medicine, both can use with the medicine being equivalent to described weight proportion for raw material respectively
Clean, be dried, pulverize, be mixed to get and meet the granule of formulation requirements granularity or powder is directly taken.Also may be used
Through suitably process after add medicinal auxiliary with the medicine being equivalent to described weight proportion relation for raw material with employing
Material, is made into various preparation as required.During being prepared as preparation by above-mentioned raw materials medicine, above-mentioned former
Material medicine can be adopted and process with the following method: the crude drug of described weight portion is directly pulverized to obtain medicinal powder；
Add water respectively or the ethanol extraction of variable concentrations or use decoction and alcohol sedimentation technique, centrifuging, steam distillation
Extract to obtain extract；Adoptable concrete operations and/or use when above-mentioned effective medicinal ingredient is extracted
Method, both can be with the ingredient of described each proportional quantities as raw material, extract its effective medicinal one-tenth respectively
Decomposite mode after point, it would however also be possible to employ the most jointly extract after mixing by each medicine material of described proportional quantities
Mode.Ideal required when using different extraction means, equipment and extract or optimal Extracting temperature,
The actual conditionses such as solvent load, extraction time, extraction time, then can be sieved by test according to practical situation
Select and find.
A kind of method of any of the above all can prepare the active component of the present composition, this active component
Can directly be used as medicine and take or add acceptable adjuvant on pharmaceutics required preparation is produced in conventional fashion into.
As conventional tablet (dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, effervescent can be made
Sheet), capsule (hard capsule, soft capsule), granule, pill (drop pill), the solid preparation such as powder
The oral drugs of form, it is also possible to make the mouth of the liquid forms such as syrup, medicated wine, tincture, oral liquid
Take medicine thing；Can also make unguentum, gel, ointment, cataplasma, emplastrum, liniment, lotion,
The external used medicine of the external preparation forms such as liniment.Therefore, in this pharmaceutical composition in addition to effective ingredient, also
Can be containing pharmaceutically acceptable adjuvant.
The preparation technology of the preparations such as tablet described here, capsule, granule relates to adopting of granulating process
With wet granulation or one-step palletizing.
Adjuvant described here, can be different according to different preparations, as tablet, capsule,
Live in diluent conventional in the solid preparations such as granule, disintegrating agent, excipient, binding agent, lubricant, surface
Property agent, filler etc.；Surfactant conventional in the liquid forms such as syrup, oral liquid, dilution
Agent, preservative, stabilizer, correctives, thickening agent, fluidizer etc.；In the external such as gel, ointment
Acceptable oil base conventional in dosage form, aqueous matrix, preservative, antioxidant, wetting agent, transdermal
Absorption enhancer, surfactant etc..
Its conventional adjuvant such as starch, lactose, sucrose, dextrin, Icing Sugar, microcrystalline Cellulose, mannitol, wood
Sugar alcohol, Polyethylene Glycol, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, modified starch, sorbitol, polyethylene pyrrole
Pyrrolidone, Heavy Magnesium Carbonate, sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, methylcellulose, ethyl
Cellulose, carboxymethylstach sodium, hydroxypropyl cellulose, PVP K30, kaolin, pregelatinized Starch, tristearin
Acid magnesium, Pulvis Talci, micropowder silica gel, stevioside, glycine betaine, aspartame, glycyrrhizin, saccharin sodium,
Crystal sugar, Mel, citric acid, sodium bicarbonate, sodium carbonate, carrageenan, agar, gelatin, sodium alginate,
Xanthan gum, guar gum, tragcanth, arabic gum, locust bean gum, POLY-karaya, stearic acid, list are hard
Glycerol, polyacrylamide, cross linked sodium polyacrylate, polyvinyl alcohol, carbomer, sorbic acid,
Potassium sorbate, ethyl hydroxybenzoate, benzyl alcohol, nipalgin, thimerosal, dimethyl sulfoxide, azone, three ethanol
Amine, sodium hydroxide, glycerol, propylene glycol, BHT, BHA, sodium lauryl sulphate, Tweens, spans
Deng.
In order to make each component of said composition can preferably play drug effect, preferably weight portion of the present invention is joined
The component of ratio takes following preparation method, but cannot be used for limiting the scope of the invention.
The preparation method of present composition medicated wine is as follows:
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 1-3 times
Measure 30 ° of-60 ° of Chinese liquor to infiltrate 1-3 hour, load and percolate pot adds 30 ° of-60 ° of Chinese liquor dipping 12-48
Hour, percolation, collect appropriate percolate, filter, add appropriate amount of auxiliary materials, mixing, adjust alcoholic strength to 30 °
-40 °, allocate to full dose, cold preservation, filter, to obtain final product.
The preparation method of present composition medicated wine is preferably:
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 2 times amount
50 ° of Chinese liquor infiltrate 2 hours, load and add 50 ° of Chinese liquor dippings in percolate pot 24 hours, and percolation is collected suitable
Measuring percolate, filter, add appropriate amount of auxiliary materials, mixing, adjustment alcoholic strength, to 35 ° ± 1 °, is allocated to full dose,
Cold preservation, filters, to obtain final product.
Wherein, one or more during adjuvant refers to crystal sugar, sucrose, Mel；It is preferably crystal sugar.
The preparation method of present composition tablet is:
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, add water or variable concentrations
Ethanol extraction, extracting solution merge, filter, filtrate decompression dry, pulverize into fine powder, add appropriate filler,
Disintegrating agent, correctives, mixing, pelletize, be dried, add magnesium stearate, mixing, tabletting, coating or not
Coating, obtains tablet.
The preparation method of present composition granule is:
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, add water or variable concentrations
Ethanol extraction, extracting solution merges, and filters, and filtrate decompression dry, pulverize into fine powder, adds appropriate amount of auxiliary materials,
Mixing, alcohol granulation, it is dried, granulate, obtains granule.
Only obtained through refining to the present invention method of above-mentioned preparation method is enumerated, but this should not be interpreted as system of the present invention
Preparation Method is only limited to above-mentioned cited method.
The detailed description of the invention of form by the following examples, makees the most in detail the foregoing of the present invention
Describe in detail bright.But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to below example.All bases
The technology realized in foregoing of the present invention belongs to the scope of the present invention.
Detailed description of the invention
Embodiment 1
Radix Ginseng 15g, cervus elaphus linnaeus 5g, Fructus Lycii 30g, Rhizoma Gastrodiae 30g, Cortex Eucommiae 30g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 2 times amount
50 ° of Chinese liquor infiltrate 2 hours, load and add 50 ° of Chinese liquor dippings in percolate pot 24 hours, and percolation is collected suitable
Amount percolate, filters, adds appropriate crystal sugar, mixing, and adjustment alcoholic strength, to 35 ° ± 1 °, is allocated to full dose,
Cold preservation, filters, to obtain final product.
Embodiment 2
Radix Ginseng 10g, cervus elaphus linnaeus 8g, Fructus Lycii 25g, Rhizoma Gastrodiae 35g, Cortex Eucommiae 25g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 2 times amount
50 ° of Chinese liquor infiltrate 2 hours, load and add 50 ° of Chinese liquor dippings in percolate pot 24 hours, and percolation is collected suitable
Amount percolate, filters, adds appropriate crystal sugar, mixing, and adjustment alcoholic strength, to 35 ° ± 1 °, is allocated to full dose,
Cold preservation, filters, to obtain final product.
Embodiment 3
Radix Ginseng 20g, cervus elaphus linnaeus 3g, Fructus Lycii 35g, Rhizoma Gastrodiae 25g, Cortex Eucommiae 35g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 2 times amount
50 ° of Chinese liquor infiltrate 2 hours, load and add 50 ° of Chinese liquor dippings in percolate pot 24 hours, and percolation is collected suitable
Amount percolate, filters, adds appropriate crystal sugar, mixing, and adjustment alcoholic strength, to 35 ° ± 1 °, is allocated to full dose,
Cold preservation, filters, to obtain final product.
Embodiment 4
Radix Ginseng 5g, cervus elaphus linnaeus 15g, Fructus Lycii 10g, Rhizoma Gastrodiae 50g, Cortex Eucommiae 10g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 2 times amount
50 ° of Chinese liquor infiltrate 2 hours, load and add 50 ° of Chinese liquor dippings in percolate pot 24 hours, and percolation is collected suitable
Amount percolate, filters, adds appropriate crystal sugar, mixing, and adjustment alcoholic strength, to 35 ° ± 1 °, is allocated to full dose,
Cold preservation, filters, to obtain final product.
Embodiment 5
Radix Ginseng 30g, cervus elaphus linnaeus 1g, Fructus Lycii 50g, Rhizoma Gastrodiae 10g, Cortex Eucommiae 50g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 2 times amount
50 ° of Chinese liquor infiltrate 2 hours, load and add 50 ° of Chinese liquor dippings in percolate pot 24 hours, and percolation is collected suitable
Amount percolate, filters, adds appropriate crystal sugar, mixing, and adjustment alcoholic strength, to 35 ° ± 1 °, is allocated to full dose,
Cold preservation, filters, to obtain final product.
Embodiment 6
Radix Ginseng 15g, cervus elaphus linnaeus 10g, Fructus Lycii 20g, Rhizoma Gastrodiae 32g, Cortex Eucommiae 28g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 1 times amount
60 ° of Chinese liquor infiltrate 3 hours, load and add 60 ° of Chinese liquor dippings in percolate pot 12 hours, and percolation is collected suitable
Amount percolate, filters, adds appropriate crystal sugar, mixing, and adjustment alcoholic strength is to 30 °, and allotment is to full dose, cold
Hide, filter, to obtain final product.
Embodiment 7
Radix Ginseng 18g, cervus elaphus linnaeus 4g, Fructus Lycii 22g, Rhizoma Gastrodiae 27g, Cortex Eucommiae 20g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 3 times amount
30 ° of Chinese liquor infiltrate 1 hour, load and add 30 ° of Chinese liquor dippings in percolate pot 48 hours, and percolation is collected suitable
Amount percolate, filters, and adds proper honey, crystal sugar, mixing, and adjustment alcoholic strength is to 40 °, and allotment is to entirely
Amount, cold preservation, filter, to obtain final product.
Embodiment 8
Radix Ginseng 12g, cervus elaphus linnaeus 10g, Fructus Lycii 15g, Rhizoma Gastrodiae 40g, Cortex Eucommiae 40g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 2 times amount
40 ° of Chinese liquor infiltrate 3 hours, load and add 40 ° of Chinese liquor dippings in percolate pot 30 hours, and percolation is collected suitable
Amount percolate, filters, and adds suitable amount of sucrose, mixing, and adjustment alcoholic strength is to 35 °, and allotment is to full dose, cold
Hide, filter, to obtain final product.
Embodiment 9
Radix Ginseng 25g, cervus elaphus linnaeus 7g, Fructus Lycii 20g, Rhizoma Gastrodiae 40g, Cortex Eucommiae 20g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, add 10 times amount water extraction 3
Secondary, each 2 hours, extracting solution merged, and filtered, and filtrate decompression dry, pulverize into fine powder, added appropriate
Carboxymethyl starch sodium, micropowder silica gel, microcrystalline Cellulose, polyvinylpolypyrrolidone, xylitol, be sufficiently mixed,
Alcohol granulation, is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, and film coating obtains sheet
Agent.
Embodiment 10
Radix Ginseng 15g, cervus elaphus linnaeus 6g, Fructus Lycii 30g, Rhizoma Gastrodiae 20g, Cortex Eucommiae 40g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, add 10 times amount 70% ethanol
Extracting 3 times, each 2 hours, extracting solution merged, and filtered, and reclaims ethanol, filtrate reduced in volume, is dried,
It is ground into fine powder, adds appropriate mannitol, lactose, dextrin, aspartame, be sufficiently mixed, ethanol system
Grain, is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, and film coating obtains tablet.
Embodiment 11
Radix Ginseng 20g, cervus elaphus linnaeus 4g, Fructus Lycii 20g, Rhizoma Gastrodiae 40g, Cortex Eucommiae 20g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, add 10 times amount water extraction 3
Secondary, each 2 hours, extracting solution merged, and filtered, and filtrate decompression dry, pulverize into fine powder, add lactose,
Mannitol is appropriate, mixing, and alcohol granulation is dried, granulate, obtains granule.
Embodiment 12
Radix Ginseng 13g, cervus elaphus linnaeus 7g, Fructus Lycii 28g, Rhizoma Gastrodiae 32g, Cortex Eucommiae 28g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, add 10 times amount 70% ethanol
Extracting 3 times, each 2 hours, extracting solution merged, and filtered, and reclaims ethanol, filtrate reduced in volume, is dried,
Being ground into fine powder, add sucrose, aspartame, dextrin is appropriate, mixing, and alcohol granulation is dried, granulate,
Obtain granule.
Embodiment 13
Radix Ginseng 17g, cervus elaphus linnaeus 4g, Fructus Lycii 32g, Rhizoma Gastrodiae 28g, Cortex Eucommiae 32g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, add 12 times amount water extraction 2
Secondary, each 2 hours, extracting solution merged, and filtered, and filtrate decompression dry, pulverize into fine powder, added appropriate
Adjuvant, mixing, pelletize, be dried, encapsulated, obtain capsule.
Embodiment 14
Radix Ginseng 20g, cervus elaphus linnaeus 10g, Fructus Lycii 25g, Rhizoma Gastrodiae 25g, Cortex Eucommiae 35g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, add 8 times amount 70% ethanol and carry
Taking 2 times, each 2 hours, extracting solution merges, and filters, and reclaims ethanol, filtrate reduced in volume, is dried,
It is ground into fine powder, adds appropriate amount of auxiliary materials, mixing, make pill.
Embodiment 15
Radix Ginseng 25g, cervus elaphus linnaeus 5g, Fructus Lycii 15g, Rhizoma Gastrodiae 45g, Cortex Eucommiae 15g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, add 10 times amount 60% ethanol
Extracting 3 times, each 1.5 hours, extracting solution merged, and filtered, and reclaims ethanol, filtrate reduced in volume, does
Dry, it is ground into fine powder, makes powder.
Embodiment 16
Radix Ginseng 15g, cervus elaphus linnaeus 8g, Fructus Lycii 35g, Rhizoma Gastrodiae 35g, Cortex Eucommiae 25g
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, add 10 times amount 70% ethanol
Extracting 2 times, each 2 hours, extracting solution merged, and filtered, recovery ethanol, filtrate reduced in volume, according to
Common process makes tincture.
According to foregoing, without departing under basic fundamental thought premise of the present invention, common according to this area
Technological know-how and customary means, it is clear that the amendment of other various ways can also be made, replace and change.
The beneficial effect of of the present invention compositions be expanded on further by following experiment:
1, test material
Test group: prepared by the embodiment of the present invention 1；Matched group: placebo.
2, experimental animal
Adult mice, body weight 18-22g, male and female half and half.
3, test apparatus
Swimming trunk (50cm × 50cm × 40cm), electronic balance, sheet lead.
4, test method
Mice being randomly divided into 2 groups, i.e. test group and matched group, often group 10, sub-cage rearing, freely drink
Food, room temperature (28 ± 2 DEG C), relative humidity 45%-48%, timing every night gavage, every day 1 time, continuously
Gavage 30 days.After last gavage, the mice of root of the tail portion load 5% body weight sheet lead is placed in swimming trunk went swimming.
The depth of water is no less than 30cm, water temperature 25 DEG C ± 1.0 DEG C, and record mice starts to the dead time from swimming, i.e.
The mice burden swimming time.
5, result of the test
The walking weight load of test group mice compares with matched group, and difference has significance (P ＜ 0.05), tool
Body is shown in Table 1.
The table 1 mice burden swimming time
*: compare with matched group, difference has significance, P ＜ 0.05.
Embodiment of the present invention 2-16 has carried out similar test, result and the above results phase the most according to the method described above
With.
6, conclusion
After the mouse stomach present composition, comparing with blank group, walking weight load is obviously prolonged,
Difference has significance (P ＜ 0.05).The prompting present composition has function of relieving physical fatigue.
Claims (10)
1. a compositions with function of physical fatigue alleviation, it is characterised in that it is by following weight portion
Component composition: Radix Ginseng 5-30 part, cervus elaphus linnaeus 1-15 part, Fructus Lycii 10-50 part, Rhizoma Gastrodiae 10-50 part,
Cortex Eucommiae 10-50 part.
Compositions the most according to claim 1, it is characterised in that it is by the component of following weight portion
Composition: Radix Ginseng 10-20 part, cervus elaphus linnaeus 3-8 part, Fructus Lycii 25-35 part, Rhizoma Gastrodiae 25-35 part, the Cortex Eucommiae
25-35 part.
3. the preparation method of compositions described in claim 1 or 2, it is characterised in that it is prepared:
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae and directly pulverize to obtain medicinal powder；
Or add water or the ethanol extraction of variable concentrations, extracting solution concentrate drying obtains crude extract；Or use water to carry further
Alcohol deposition method, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation
One or more be used in combination suitably refine after extract；Above-mentioned medicinal powder or crude extract or essence
Extract is not added with or adds appropriate amount of auxiliary materials, and technique makes acceptable preparation on pharmaceutics routinely.
Preparation method the most according to claim 3, it is characterised in that described preparation refer to tablet,
Granule, capsule, pill, powder, tincture, medicated wine.
Preparation method the most according to claim 4, it is characterised in that described preparation refers to medicated wine.
Preparation method the most according to claim 5, it is characterised in that medicated wine is prepared:
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 1-3 times
Measure 30 ° of-60 ° of Chinese liquor to infiltrate 1-3 hour, load and percolate pot adds 30 ° of-60 ° of Chinese liquor dipping 12-48
Hour, percolation, collect appropriate percolate, filter, add appropriate amount of auxiliary materials, mixing, adjust alcoholic strength to 30 °
-40 °, allocate to full dose, cold preservation, filter, to obtain final product.
Preparation method the most according to claim 6, it is characterised in that medicated wine is prepared:
Take the Radix Ginseng of described weight portion, cervus elaphus linnaeus, Fructus Lycii, Rhizoma Gastrodiae, the Cortex Eucommiae, broken, add 2 times amount
50 ° of Chinese liquor infiltrate 2 hours, load and add 50 ° of Chinese liquor dippings in percolate pot 24 hours, and percolation is collected suitable
Measuring percolate, filter, add appropriate amount of auxiliary materials, mixing, adjustment alcoholic strength, to 35 ° ± 1 °, is allocated to full dose,
Cold preservation, filters, to obtain final product.
8. according to the preparation method described in claim 6 or 7, it is characterised in that described adjuvant refers to ice
One or more in sugar, sucrose, Mel.
Preparation method the most according to claim 8, it is characterised in that described adjuvant refers to crystal sugar.
10. compositions described in claim 1 or 2 has the health care food of function of physical fatigue alleviation for preparation
Application in product.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107279984A (en) * | 2017-07-18 | 2017-10-24 | 吉林青晨药业有限公司 | Technology of preparing with the gentle physical fatigue functional health product of strengthen immunity |
| CN107997166A (en) * | 2016-11-01 | 2018-05-08 | 北京振东光明药物研究院有限公司 | A kind of health products and preparation method for improving sleep, relieving fatigue strengthen immunity |
| CN108065351A (en) * | 2016-11-18 | 2018-05-25 | 吉林省东鳌鹿业集团有限公司 | It is a kind of to have the function of to alleviate physical fatigue, the composition and preparation method thereof of strengthen immunity |
| CN108208814A (en) * | 2018-02-02 | 2018-06-29 | 习水红四渡仙人掌产业有限公司 | A kind of health product of cactus and preparation method thereof |
| CN110269897A (en) * | 2019-07-12 | 2019-09-24 | 成都中医药大学 | Composition and application thereof that is a kind of antifatigue and improving sleep |
| CN112494569A (en) * | 2020-12-30 | 2021-03-16 | 森隆药业有限公司 | Traditional Chinese medicine composition for improving immunity and preparation method and application thereof |
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| CN102586066A (en) * | 2012-03-14 | 2012-07-18 | 济南宏济堂制药有限责任公司 | Health-care wine and preparation method thereof |
| CN104336593A (en) * | 2013-07-25 | 2015-02-11 | 浙江天一堂创业投资有限公司 | Ginseng, hairy antler and dendrobium health food and its making method |
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| CN102586066A (en) * | 2012-03-14 | 2012-07-18 | 济南宏济堂制药有限责任公司 | Health-care wine and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107997166A (en) * | 2016-11-01 | 2018-05-08 | 北京振东光明药物研究院有限公司 | A kind of health products and preparation method for improving sleep, relieving fatigue strengthen immunity |
| CN108065351A (en) * | 2016-11-18 | 2018-05-25 | 吉林省东鳌鹿业集团有限公司 | It is a kind of to have the function of to alleviate physical fatigue, the composition and preparation method thereof of strengthen immunity |
| CN107279984A (en) * | 2017-07-18 | 2017-10-24 | 吉林青晨药业有限公司 | Technology of preparing with the gentle physical fatigue functional health product of strengthen immunity |
| CN108208814A (en) * | 2018-02-02 | 2018-06-29 | 习水红四渡仙人掌产业有限公司 | A kind of health product of cactus and preparation method thereof |
| CN110269897A (en) * | 2019-07-12 | 2019-09-24 | 成都中医药大学 | Composition and application thereof that is a kind of antifatigue and improving sleep |
| CN110269897B (en) * | 2019-07-12 | 2021-04-13 | 成都中医药大学 | Composition for resisting fatigue and improving sleep and application thereof |
| CN112494569A (en) * | 2020-12-30 | 2021-03-16 | 森隆药业有限公司 | Traditional Chinese medicine composition for improving immunity and preparation method and application thereof |
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