CN104352552B - A kind of food, health products or pharmaceutical composition - Google Patents
A kind of food, health products or pharmaceutical composition Download PDFInfo
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- CN104352552B CN104352552B CN201410544921.4A CN201410544921A CN104352552B CN 104352552 B CN104352552 B CN 104352552B CN 201410544921 A CN201410544921 A CN 201410544921A CN 104352552 B CN104352552 B CN 104352552B
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- hickory chick
- kudzuvine root
- root starch
- food
- health products
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- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 150000001896 cresols Chemical class 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 1
- 229960000452 diethylstilbestrol Drugs 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000005305 organ development Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000036259 sexual stimuli Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008783 wuzi yanzong Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of food, health products or pharmaceutical composition, its raw material contains the component of following weight proportion：4~10 parts of 1~3 part of hickory chick, kudzuvine root starch or pueraria lobata；The hickory chick is selected from Morchella esculenta (L.) Pers sporophore or Morchella esculenta (L.) Pers mycelium.Present invention also offers the preparation method and purposes of said composition.Present invention research finds that after hickory chick and kudzuvine root starch are used in combination, its establishing-Yang effect gets a promotion, show that the establishing-Yang effect of kudzuvine root starch to hickory chick has facilitation, also, two taste raw materials can be used as food, security is high, and new selection is provided for clinical application.
Description
Technical field
The present invention relates to a kind of food, health products or pharmaceutical composition.
Background technology
Hickory chick, latin name：Morehella esculenta (L.) Pers classifies：Mycology classification belongs to Pezizale, sheep tripe
Cordycepps, morchella.Hickory chick is also known as sheep tripe mushroom, sheep liver dish, compiles large bamboo hat with a conical crown and broad brim bacterium.Mycology classification belongs to Pezizale, Morchellaceae, sheep tripe
Pseudomonas.Also known as sheep tripe dish, sheep mushroom.Hickory chick (Morchella), also known as morel, are a kind of precious edible mushroom and medicinal fungus.
Hickory chick was found in 1818.Its structure is similar to cup fungi, and top is netted in fold, both as a honeycomb, also like a sheep tripe, because
And gain the name.Hickory chick yield in 2 to three years after mountain fire is extra-high, therefore the picker of North America can gather according to mountain fire
Hickory chick.However, after fire is controlled, in same area, its growth population can be reduced year in year out.Hickory chick
By sheep tripe shape can pregnant capitulum cap and an infertile stem form.There is a hymenium of netted rib on cap surface, edge with
Stem is connected.Stem is cylindric, hollow, smooth surface or fluted.Hickory chick is foremost delicious food bacterium in sac fungus, its
It is needed by human that 7 kinds of isoleucine, leucine, lysine, methionine, phenylalanine, threonine and valine are contained in cap part
Amino acid, it is sweet cold nontoxic, have beneficial stomach, phlegm-eliminiating and qi-regulating drug effect.
Kudzuvine root starch mainly has lipid-loweringing, decompression, fall fire, clearing heat and detoxicating, rising Yang expelling pathogenic factors from muscles and skin, spasmolysis and analgesia, promoting eruption antidiarrheal and other effects, uses
In a variety of diseases such as prevention hypertension, hyperlipidemia, coronary heart diseases and angina pectoris, diabetes, cerebral thrombus, enterogastritis, while have to women
Adjusting endocrine, cosmetology and health, chest enlarge etc. has special efficacy, this may be with phytoestrogen --- the different Huang that contains in kudzuvine root starch
Ketone is related.However, isoflavones is phytoestrogen, there is estrogen-like action, most researchs existing at present show, phytoestrogen
A large amount of intakes can influence male reproductive organ development, reducing thefunction of male reproduction, (Jiang Chunxia, Nanjing Normal University, 2008 is large
Scholar's paper；Sun Mei, Chinese experimental diagnostics, the phase of volume 2005,9 1), this may be also to have to strengthen at present there is no literature reported on kudzuvine root starch
The reason for sun effect.
The content of the invention
It is an object of the invention to provide a kind of new food, health products or pharmaceutical composition.
Specifically, the present invention provides a kind of food, health products or pharmaceutical composition, its raw material to contain Morchella esculenta (L.) Pers sporophore
Or mycelia and kudzuvine root starch or pueraria lobata.
Wherein, its raw material contains the component of following weight proportion：
4~10 parts of 1~3 part of hickory chick, kudzuvine root starch or pueraria lobata.
Further, its raw material contains the component of following weight proportion：
4 parts of 1 part of hickory chick, kudzuvine root starch or pueraria lobata.
Further, its raw material is made of the component of following weight proportion：
4~10 parts of 1~3 part of hickory chick, kudzuvine root starch or pueraria lobata.
Further, its raw material is made of the component of following weight proportion：
4 parts of 1 part of hickory chick, kudzuvine root starch or pueraria lobata.
Wherein, it by the powder of hickory chick, water extract or ethanol extract and kudzuvine root starch or pueraria lobata is active ingredient that it, which is, is added
The formulation that acceptable auxiliary material or complementary component are prepared in food, health products or medicine.
Preferably using kudzuvine root starch in the present invention.The kudzuvine root starch, i.e. pueraria starch.
Pharmaceutically acceptable auxiliary material of the present invention, refers to the material being included in addition to the active ingredient (s in formulation, bag
Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersant, wetting agent, adhesive, adjusting
Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifying agent, disintegrant etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite,
Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose
Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its
Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb
Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second
Glycol etc.；Disintegrant includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake
Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate
Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes
0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Conditioning agent includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron
Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.；Emulsifying agent includes Tween-80, aliphatic acid sorb
Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerine etc..
The pharmaceutically acceptable complementary component, it has certain physiological activity, but the addition of the component will not change
Become the leading position of above-claimed cpd or derivative in treatment of diseases, and only play auxiliary effect, these auxiliary work(
Effect is only the utilization to the component known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary into
Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Further, the formulation is through intestines and stomach absorption type.
Wherein, the hickory chick is selected from Morchella esculenta (L.) Pers sporophore or Morchella esculenta (L.) Pers mycelium.
Further, the Morchella esculenta (L.) Pers mycelium is the Morchella esculenta (L.) Pers mycelium of pueraria root residue culture.
Further, in the Morchella esculenta (L.) Pers mycelium, general flavone content is not less than 7% in terms of Puerarin.
In a concrete mode of the invention, the cultural method of the Morchella esculenta (L.) Pers mycelium of pueraria root residue culture is as follows：
(1) culture medium is prepared
Make potato culture medium：Potato (peeling) 200g, glucose 20g, agar 20g, water 1000ml.Potato is cut
It is put into fritter in pot, adds water 1000ml, boiled 20 minutes, with filtered through gauze, moisturizing to 1000ml, is put into agar and grape
Sugar, after heating dissolving, adjusts PH6.0 (potassium dihydrogen phosphate, dipotassium hydrogen phosphate solution), culture medium is dispensed in conical flask, every bottle
Load 1/3 capacity culture medium, 0.1-0.15MPa steam high-voltage sterilizings 30min；
(2) actication of culture
Strain is taken out from strain library, in being inoculated with aseptic operating platform, uses shaking table shaken cultivation.Rotating speed 60-150r/
Min, 20-25-30 DEG C of temperature, is cultivated 5-7 days；
(3) seed culture
Make seed culture fluid：Glucose 20g, gypsum 2g, analysis for soybean powder 10g, malt flour 2g, 20% potato juice 1000ml
PH6.0 (potassium dihydrogen phosphate, dipotassium hydrogen phosphate solution) is adjusted after preparation, is sub-packed in the triangular flask of 500ml, it is high per bottled 150ml
Pressure sterilizing.In the strain 5-10ml that activation is inoculated with aseptic operating platform, shaking table shaken cultivation is used.Rotating speed 60-120r/min,
20-25-30 DEG C, cultivate 5-7 days；
(4) inoculation and culture
Fresh pueraria root residue (or dry pueraria root residue adds 3-6 times of water saturates) is fitted into culture vessel, pueraria root residue volume accounts for culture and holds
The 1/4-2/3 of device, through 121 DEG C of sterilizing 20-30min, after taking out culture vessel, is aseptically inoculated with and aseptically connects
Kind seed culture fluid, inoculum concentration 1-10%：20-25-30 DEG C, cultivate 5-30 days.After being covered with Deng mycelia, through 121 DEG C of sterilizing 20-
30min, uses after 50-100 DEG C dry.
Further, the raw material further includes ganoderma lucidum or lucidum spore powder.
Further, the lucidum spore powder is selected from wall-breaking lucidum robe powder.
Ganoderma spove powder can be prepared according to current conventional ganoderma lucidum wall-broken method.
Wherein, in the food, health products or pharmaceutical composition, its raw material is made of the component of following weight proportion：
Component A：Ganoderma lucidum or lucidum spore powder=2~4：2~8w/w；Wherein, component A raw materials are 1~3 part of hickory chick, Pueraria lobota
4~10 parts of powder or pueraria lobata.
Further, component A raw materials are 4 parts of 1 part of hickory chick, kudzuvine root starch or pueraria lobata.
Wherein, the component A is made of the ethanol extract and kudzuvine root starch or pueraria lobata of hickory chick.
Wherein, concentration of alcohol is in more than 40%v/v.In an embodiment of the invention, concentration of alcohol for 70~
90%.
Wherein, the lucidum spore powder is preferably wall-breaking lucidum robe powder.
Present invention also offers the preparation method of above-mentioned food, health products or pharmaceutical composition, it includes following operation and walks
Suddenly：
(1) raw material is weighed by proportioning；
(2) powder, water extract or ethanol extract of hickory chick are taken, food, health care are mixed with kudzuvine root starch or pueraria lobata
Product or medicine.
Further, concentration of alcohol is in more than 40%v/v.In an embodiment of the invention, concentration of alcohol 70
~90%.
Present invention also offers above-mentioned food, health products or pharmaceutical composition to prepare antifatigue, prevention, treatment or auxiliary
Treat the purposes in the food, health products or medicine of male reproductive function obstacle.
Further, the male reproductive function obstacle is impotence.
It is used to prepare and controls present invention also offers above-mentioned food, health products or pharmaceutical composition and ganoderma lucidum or lucidum spore powder
Treat antifatigue, the purposes in the combination medicine of prevention, treatment or auxiliary treatment male reproductive function obstacle.
In the food, health products or pharmaceutical composition, its raw material is made of the component of following weight proportion：
4~10 parts of 1~3 part of hickory chick, kudzuvine root starch or pueraria lobata.
Further, its raw material is made of the component of following weight proportion：4 parts of 1 part of hickory chick, kudzuvine root starch or pueraria lobata.
Further, the food, health products or pharmaceutical composition are using the ethanol extract of hickory chick and kudzuvine root starch as activity
Component；The lucidum spore powder is preferably wall-breaking lucidum robe powder.
Wherein, concentration of alcohol is in more than 40%v/v.In an embodiment of the invention, concentration of alcohol for 70~
90%.
Further, the food, health products or pharmaceutical composition and the consumption proportion of ganoderma lucidum or lucidum spore powder are：
2~4：2~8w/w.
Currently the research report to kudzuvine root starch shows wherein to contain osajin component, and generally acknowledged osajin component is at present
Phytoestrogen, can reduce thefunction of male reproduction, if according to prior art inference, kudzuvine root starch should not have establishing-Yang effect, or even can
It can reduce thefunction of male reproduction.However, present invention research has been surprisingly found that, and after hickory chick and kudzuvine root starch are used in combination, hickory chick
Establishing-Yang effect gets a promotion, and shows that the establishing-Yang effect of kudzuvine root starch to hickory chick does not have the effect of antagonism not only, the anti-work(for having promotion, it is controlled
It is even suitable with classical prescribed preparation remittance benevolence SHENBAO HEJI to treat impotence effect.It is presently believed that kudzuvine root starch is mainly pueraria starch class
Material, wherein in addition to isoflavones components, also promotes hickory chick to strengthen containing the other compositions such as carbohydrate, amino acid, trace element, kudzuvine root starch
Positive this effect of activity may be closely related with the other compositions beyond institute's isoflavone-containing in kudzuvine root starch.
In addition, converge 20 pleasant impression Chinese medicines of the full side of benevolence SHENBAO HEJI, be《Danxi's experiential therapy》" wuzi yanzong pills " that record,《With
Agent office side》" Sijunzi Tang " recorded, and《Jing Yue's complete work》Plus-minus side on the basis of " the five happinesses drink " that records and obtain, especially add
The product of the warm kidney strengthening the essence such as Herba Epimedii, faenum graecum, saline cistanche, fleece-flower root, it is curative for effect, impotence and seminal emission can be treated.Present invention research
It has also been found that only hickory chick kudzuvine root starch and three medicine of ganoderma lucidum are combined, it becomes possible to be obviously improved to diseases such as male reproductive function obstacles
The effect of, and the positive control medicine remittance benevolence SHENBAO HEJI containing 20 pleasant impression Chinese medicines is significantly better than, and each taste medicine security pole
Height, new selection is provided for clinical application.
Obviously, the above according to the present invention, according to the ordinary technical knowledge and means of this area, is not departing from this hair
Under the premise of bright above-mentioned basic fundamental thought, the modification, replacement or change of other diversified forms can also be made.
Below by way of the form of specific embodiment, the above of the present invention is described in further detail again.But no
The scope that this should be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.It is all to be realized based on the above of the present invention
Technology belong to the scope of the present invention.
Embodiment
It is prepared by 1 kudzuvine root starch of embodiment
1st, Pueraria lobota is washed：Fresh pueraria lobata cleans peeling, is cut into small pieces (2-6cm is sized for being homogenized).
2nd, it is homogenized：The pueraria lobata block cut is weighed, adds the water of 2-6 times of pueraria lobata weight to be homogenized.Filter-cloth filtering, obtains Pueraria lobota juice
Liquid.By the pueraria root residue after all filterings merge again with the water washing of 2-4 times of pueraria lobata weight once, filtering, with obtaining before
Pueraria lobota juice merges.Pueraria lobota juice centrifuges 10-30min, obtains wet kudzuvine root starch, Pueraria lobota juice, pueraria root residue, kudzuvine root starch through 1000-3000r/min
50-70 DEG C of drying, to obtain the final product.
In addition, Pueraria lobota juice is used for Puerariae drink processed, pueraria root residue is used to cultivate edible mushroom or drying for standby.
It is prepared by 2 hickory chick kudzuvine root starch of embodiment
1-3 parts of dry hickory chick (Morehella esculenta (L.) Pers) is taken to crush and kudzuvine root starch 4-10 parts of mixings, powder
It is broken to cross 60-200 mesh sieves.As hickory chick kudzuvine root starch, sold after packing directly as product, or as processing tablet, capsule etc.
The raw material of formulation.Or as raw-food materials such as soft sweets, jelly.
It is prepared by 3 hickory chick kudzuvine root starch of embodiment
Take dry hickory chick (Morehella esculenta (L.) Pers) 10-20 times of water of 1-3 parts of crushing or 10-20
Times 40-100% (volume ratio) edible ethanol extracts 1-3 time, and extracting solution filtering, recycling ethanol, is concentrated to density 1-1.2 and kudzuvine root starch
4-10 parts of mixings, 50-70 DEG C of drying, crushed 60-200 mesh sieves.Usage is the same as embodiment 2.
It is prepared by 4 hickory chick kudzuvine root starch of embodiment
Take dry hickory chick (Morehella esculenta (L.) Pers) 10-20 times of water of 1-3 parts of crushing or 10-20
Times 70-90% (volume ratio) edible ethanol extracts 1-3 time, and extracting solution filtering, recycling ethanol, is concentrated to density 1-1.2 and kudzuvine root starch
4-10 parts of mixings, 50-70 DEG C of drying, crushed 60-200 mesh sieves.Usage is the same as embodiment 2.
It is prepared by 5 hickory chick kudzuvine root starch of embodiment
Take hickory chick (Morehella esculenta (L.) Pers) to be inoculated into pueraria root residue, take cultured growth to have
The pueraria root residue of Morchella esculenta (L.) Pers mycelium replaces hickory chick (fructification) in embodiment 2,3,4, prepares hickory chick kudzuvine root starch.
Morchella esculenta (L.) Pers mycelium cultural method is as follows：
The activation of 1 strain
1.1 culture mediums are prepared
Make potato culture medium：Potato (peeling) 200g, glucose 20g, agar 20g, water 1000ml.Potato is cut
It is put into fritter in pot, adds water 1000ml, boiled 20 minutes, with filtered through gauze, moisturizing to 1000ml, is put into agar and grape
Sugar, after heating dissolving, adjusts PH6.0 (potassium dihydrogen phosphate, dipotassium hydrogen phosphate solution), culture medium is dispensed in conical flask, every bottle
Load 1/3 capacity culture medium, 0.1-0.15MPa steam high-voltage sterilizings 30min.
1.2 actication of culture
Strain (Mianyang City edible mushroom research institute of Sichuan Province, Morehella esculenta (L.) are taken out from strain library
Pers), in being inoculated with aseptic operating platform, shaking table shaken cultivation is used.Rotating speed 60-150r/min, 20-25-30 DEG C of temperature, culture
5-7 days.
1.3 seed culture
Make seed culture fluid：Glucose 20g, gypsum 2g, analysis for soybean powder 10g, malt flour 2g, 20% potato juice 1000ml
PH6.0 (potassium dihydrogen phosphate, dipotassium hydrogen phosphate solution) is adjusted after preparation, is sub-packed in the triangular flask of 500ml, it is high per bottled 150ml
Pressure sterilizing.In the strain 5-10ml that activation is inoculated with aseptic operating platform, shaking table shaken cultivation is used.Rotating speed 60-120r/min,
20-25-30 DEG C, cultivate 5-7 days.
1.4 inoculations and culture
Fresh pueraria root residue (or dry pueraria root residue adds 3-6 times of water saturates) is fitted into culture vessel, pueraria root residue volume accounts for culture and holds
The 1/4-2/3 of device, through 121 DEG C of sterilizing 20-30min, after taking out culture vessel, is aseptically inoculated with edible mushroom seed liquor 1-
10% seed culture fluid.20-25-30 DEG C, cultivate 5-30 days.After being covered with Deng mycelia, through 121 DEG C of sterilizing 20-30min, through 50-
Used after 100 DEG C of dryings.
Total triterpene, the assay of general flavone in 1.5 Morchella esculenta (L.) Pers mycelium cultures
Color developing agent (5% vanillic aldehyde-glacial acetic acid, perchloric acid).Oleanolic acid, Puerarin reference substance (middle inspection institute).
1.5.1, total triterpene contents measure
The preparation of reference substance solution：Precision weighs oleanolic acid 5.0mg and is placed in 25ml measuring bottles.Methanol is added to dissolve and dilute
To scale, shake up, it is spare.
The preparation of standard curve：Accurate reference substance solution 0.3,0.4,0.5,0.6,0.7ml of drawing is respectively placed in tool plug
In test tube, solvent is flung in water-bath, cooling, accurate to add 5% vanillic aldehydes of 0.4ml-glacial acetic acid and 1.8ml perchloric acid, is mixed, close
Plug.It is placed in 70 DEG C of waters bath with thermostatic control and heats 20min.Take out, be cooled to room temperature, acetic acid 5ml on the rocks.Surveyed after shaking up at 530nm
Determine absorption value.Drafting standard curve.
Sample size measures：Dry Morchella esculenta (L.) Pers mycelium culture powder (crossing 80 mesh sieves) about 1.0g is taken, it is accurately weighed, put
In conical flask, precision adds 95% ethanol 100mL, and weighed weight, is heated to reflux 30min, lets cool, then weighed weight, with 95%
Ethanol supplies the weight of less loss, shakes up, and filtration, takes subsequent filtrate 0.2ml, is respectively placed in the test tube of tool plug, and solvent is flung in water-bath,
Cooling, the accurate 0.4ml that adds is 5% vanillic aldehyde-glacial acetic acid and 1.8ml perchloric acid, is mixed, close plug.It is placed in 70 DEG C of waters bath with thermostatic control
Middle heating 20min.Take out, be cooled to room temperature, acetic acid 5ml on the rocks.Absorption value is measured after shaking up at 530nm, with average value table
Total triterpene contents in sample product.Total triterpene contents are in terms of oleanolic acid in results sample, not less than 5%.
1.5.2, the assay of general flavone
The preparation of reference substance solution：Precision weighs 80 DEG C of dryings to the Puerarin reference substance 5.0mg of constant weight, puts 25mL capacity
In bottle, dissolved with 95% ethanol and be diluted to scale.
The preparation of standard curve：
Sample size measures：Dry Morchella esculenta (L.) Pers mycelium culture powder (crossing 80 mesh sieves) about 1.0g is taken, it is accurately weighed, put
In conical flask, precision adds 30% ethanol 100mL, and weighed weight, is heated to reflux 30min, lets cool, then weighed weight, with 30%
Ethanol supplies the weight of less loss, shakes up, and filtration, takes subsequent filtrate appropriate, 250nm.Place's measure absorption value, sample is represented with average value
The content of middle general flavone.The content of general flavone is in terms of Puerarin in results sample, not less than 7%.
The preparation of 6 composition of embodiment
Take dry hickory chick (Morehella esculenta (L.) Pers) 10-20 times of water of 1-3 parts of crushing or 10-20
Times 40-100% (volume ratio) edible ethanol extracts 1-3 time, and extracting solution filtering, recycling ethanol, is concentrated to density 1-1.2 and kudzuvine root starch
4-10 parts of mixings, 50-70 DEG C of drying, crushed 60-200 mesh sieves, obtain mixture 1.
It is by consumption proportion with ganoderma spove powder by mixture 1：2~4：2~4w/w is mixed, encapsulated, obtains capsule
Agent.
Illustrate beneficial effects of the present invention below by way of test example.
The functional evaluation of 1 hickory chick kudzuvine root starch of test example
1st, antifatigue experiment
1.1st, experiment material
Mouse:Kunming system male mice, weight 18-22g.(production licence is provided by SanXia University's animal experimental center：
SCXK (Hubei Province) 2011-0012；Use licensing：SYXK (Hubei Province) 2011-0061).
Primary Chemical:MDA kits, BUN kits, Bioengineering Research Institute is built up by Nanjing.Other reagents
It is that analysis is pure.
1.2nd, experimental method and result
After experimental animal adaptability is fed 2 days, random packet, every group 8, be respectively control group, hickory chick powder group is (by sheep
Tripe bacterium directly crushes, and crosses 80 mesh sieves, is mixed with 1% sodium carboxymethylcellulose, dosage 1.5g/kg (refers to and is equal to hickory chick powder
The crude drug amount of the medicinal material of 1.5g/kg), hickory chick water extract group (equivalent 1.5g/kg hickory chicks, after concentration, per 20g gavages
0.2ml, similarly hereinafter), hickory chick alcohol take thing group, hickory chick silk powder group (Morchella esculenta (L.) Pers mycelium of pueraria root residue culture, with culture medium together
It dry, pulverize, cross 80 mesh sieves, mixed with 1% sodium carboxymethylcellulose, dosage 1.5g/kg, refers to and be equal to hickory chick powder
The crude drug amount of the medicinal material of 1.5g/kg), hickory chick silk powder water extract group, hickory chick silk powder 70~90%v/v alcohol take thing group, sheep tripe
Bacterium kudzuvine root starch group (hickory chick powder and kudzuvine root starch 1：4 mix, and dosage 1.5g/kg, refers to the life for the medicinal material for being equal to hickory chick powder 1.5g/kg
Dose), hickory chick 70~90%v/v alcohol takes thing kudzuvine root starch group (alcohol equivalent to 1 part of hickory chick takes thing and 4 parts of kudzuvine root starch to mix, agent
Amount is suitable with hickory chick kudzuvine root starch group), hickory chick thread 70~90%v/v alcohol take thing kudzuvine root starch (equivalent to the sheep tripe of 1 part of pueraria root residue culture
The alcohol of bacterium culture takes thing and 4 parts of kudzuvine root starch to mix, and dosage is suitable with hickory chick kudzuvine root starch group) group.Gastric infusion, control group mice
With isometric sodium carboxymethylcellulose gavage, continuous gavage 7 days.30min after the last administration, mouse tail load relative to
The sheet lead of weight 5%, is then placed in the disposable swimming of progress in 30 ± 2 DEG C of water by mouse and is exhausted to power, record swimming time.
The criterion that power exhausts:Mouse submerged is more than 10s.Mouse is placed in dry mouse cage, eyeball blood sampling is plucked after recovering 24h.
3000r/min is centrifuged 15 minutes, is suctioned out serum, is put in 4 DEG C of refrigerators and save backup.By kit method measure MDA (malonaldehyde),
BUN (blood urea nitrogen) content.It the results are shown in Table 1.
1 hickory chick kudzuvine root starch of table to tired mouse movement endurance influence (N=8)
Note：* p compared with the control group<0.05,**P<0.01.
Experiment shows：Each medication group can significantly increase mouse movement endurance, reduce Serum MDA, blood urea nitrogen content.
With significantly to antifatigue effect.Wherein hickory chick or hickory chick silk alcohol takes thing effect preferable, and effect enhancing is shared with kudzuvine root starch.
2nd, impotence experiment is treated
Male white mouse is grouped at random, every group 8.Cause male white mouse sexual function vigor low by suspention, so
Effect of the medicine to the model is observed afterwards.Normal group control group, daily free diet are without any processing；Model group daily will
Two back legs of small white mouse are suspended to the top of sink with rope bolt jail, the built-in people's tap water of groove (water temperature is controlled at 20 ± 2 DEG C),
The head of small white mouse is set to force small white mouse constantly to come back, struggle just close to the water surface, each 30min, one time a day.Totally 7 days.
Gastric infusion, control group the isometric sodium carboxymethylcellulose gavage of model group mouse.Each group is opened for first day in experiment
Begin, after each suspension stress, male white mouse and female small white mouse are pressed 1:1 mates to divide, and observes riding for male white mouse
Across or mating incubation period, and ride and number of copulations.Daily stilbestrol is subcutaneously injected in mating first 3 days in female small white mouse
1mg/kg, mates daily hypodermic injection progesterone 10mg/kg after beginning.Experiment is mated respectively to carry out 1 time within the 4th, 6 day in experiment.7th
30min after its administration, plucks eyeball blood sampling.3000r/min is centrifuged 15 minutes, is suctioned out serum, is put in 4 DEG C of refrigerators and save backup.Press
Kit method measures Testosterone Content in Serum, the results are shown in Table 2,3
The influence preclinical on sexual disorder mouse of 2 hickory chick kudzuvine root starch of table (N=8)
Note：* p compared with the control group<0.05,**P<0.01.
Experiment shows：Each medication group can significantly shorten sexual disorder mouse incubation period.Wherein hickory chick or hickory chick silk
Alcohol takes thing effect preferably, and after being shared with kudzuvine root starch, effect has enhancing trend.Kudzuvine root starch is currently known without yang invigorating functions, it is contained therein very
After may extremely have reduces the influence of reproductive function, but both share, establishing-Yang increased activity, shows that kudzuvine root starch has and promotes hickory chick to have
Improve the effect of sexual disorder.
Sexual disorder mouse is ridden 3 hickory chick kudzuvine root starch of table or the influence of number of copulations (N=8)
Note：* p compared with the control group<0.05,**P<0.01.
Experiment shows：Each medication group can dramatically increase sexual disorder mouse and ride or number of copulations.Wherein hickory chick or
Hickory chick silk alcohol takes thing effect preferably, and after being shared with kudzuvine root starch, effect has enhancing trend.Kudzuvine root starch is currently known without yang invigorating functions, but
After both share, establishing-Yang increased activity, shows that kudzuvine root starch plays the role of promoting hickory chick to have improvement sexual disorder.
4 hickory chick kudzuvine root starch of table to sexual disorder mice serum testosterone levels influence (N=8)
Experiment shows：Each medication group can improve sexual disorder mice serum testosterone concentration.But with model group comparing difference
It is not notable.
3rd, impotence clinical observation is treated
3.1st, 60 outpatient services of Yichang City's traditional Chinese medical science courtyard or in hospital impotent patient are at random treatment group, compareed by general information
The data comparing differences such as group, every group of 20 people, each group age, the course of disease, severity extent are without conspicuousness (P>0.05), it is comparable.
3.1.1, diagnostic criteria is with reference to compilings such as Wu Jieping professors《Sex medicine》In related standard draft.That is adult man
Property is under effective sexual stimulus, though penis anorthosis has sexual intercourse or penis can erect the hardness that cannot remain enough and complete
Sexual intercourse.
3.1.2, inclusive criteria (1) is married, and the male of 20~60 years old that living conditions are good.(2) because medicine causes sun
Wither, but disable now in relation to the medicine for influencing sexual function up to more than 3 months.
3.1.3, the organic impotence patient that exclusion standard (1) has been made a definite diagnosis.(2) Drug impotent patient.(3) spouse has entirely
The serious organic disease person of body.(4) severe primary such as angiocarpy, liver, kidney and hemopoietic system disease and cyclothymic are associated with
Person.(5) inclusive criteria is not met, not by regulation medication, can not judge that congruent affect the treatment is not sentenced with security for curative effect or data
Disconnected person.
3.2nd, treatment method
Treat 1 group：Thing kudzuvine root starch is taken to treat using hickory chick silk alcohol.Each 2-4g, takes 1 time, warm water is sent after dinner every night
Clothes.
Treat 2 groups：Thing kudzuvine root starch is taken to add Reishi sporule treated powder using hickory chick silk alcohol.Thing Pueraria lobota is taken each taking hickory chick silk alcohol
Powder 2-4g, takes 1 time, warm water delivery service after dinner every night.It is 1-2 times daily at the same time each taking ganoderma spove powder 2-4g, early,
Late warm water delivery service.
Control group：Remittance benevolence SHENBAO HEJI is taken orally, every time 10~20m, 3 times a day.
Three groups of the above, for 1 course for the treatment of, curative effect is counted after 2 courses for the treatment of with 1 month.And it is right during two groups of treatments to disable other
The medicative Chinese and western drugs of impotence and cause sexual excitement, other therapeutic method of traditional Chinese and western medicine of sex dysfunction.
In this experiment, hickory chick silk alcohol takes thing kudzuvine root starch with test example 1.
3.3rd, treatment results
3.3.1, criterion of therapeutical effect.Cure in the recent period:After treatment within 3 months, telotism>90 degree, the 75% of sexual intercourse chance
Above can success；It is effective:Telotism after treatment>90 degree, the 50% of sexual intercourse chance can success；Effectively:Telotism after treatment
There is improvement, more than the 25% of sexual intercourse chance can success；It is invalid:Pretherapy and post-treatment indices are without improvement.Treatment results are shown in Table 5.
5 hickory chick kudzuvine root starch of table to treat impotent patient influence (N=8)
Note：* * P compared with the control group<0.01.
Clinical observation result shows：Hickory chick silk alcohol takes thing kudzuvine root starch, hickory chick silk alcohol to take thing kudzuvine root starch to add lucidum spore powder to control
Treat impotence satisfactory effect.Hickory chick silk alcohol takes thing kudzuvine root starch with lucidum spore powder use in conjunction in recent cure rate and total effective rate side
Face is significantly better than that control group.Hickory chick silk alcohol take thing kudzuvine root starch in terms of recent cure rate and total effective rate with control group phase
When.Show that hickory chick is shared with treatment impotence effect with kudzuvine root starch, hickory chick, kudzuvine root starch and lucidum spore powder use in conjunction effect are more
It is good.
Claims (4)
1. a kind of antifatigue food, health products or pharmaceutical composition, it is characterised in that：Its raw material by following weight proportion group
It is grouped into：4 parts of 1 part of hickory chick, kudzuvine root starch or pueraria lobata；
The hickory chick is selected from Morchella esculenta (L.) Pers sporophore；
It by the ethanol extract and kudzuvine root starch or pueraria lobata of hickory chick is active ingredient that it, which is, plus can in food, health products or medicine
The formulation that the auxiliary material of receiving or complementary component are prepared.
2. the preparation method of food, health products or pharmaceutical composition described in claim 1, it is characterised in that：It includes following behaviour
Make step：
（1）Raw material is weighed by proportioning；
（2）The ethanol extract of Morchella esculenta (L.) Pers sporophore is taken, food, health products or medicine are mixed with kudzuvine root starch or pueraria lobata.
3. preparation method according to claim 2, it is characterised in that：Concentration of alcohol is in more than 40%v/v.
4. food, health products or pharmaceutical composition are in antifatigue food, health products or medicine is prepared described in claim 1
Purposes.
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| CN106262515A (en) * | 2016-08-12 | 2017-01-04 | 四川清和正本生物科技有限公司 | A kind of have relieving constipation and promote the food of sleep effect, health product or pharmaceutical composition and its production and use |
| CN107997123A (en) * | 2017-11-28 | 2018-05-08 | 北京康比特体育科技股份有限公司 | A kind of composition for promoting lactic acid to remove |
| TWI661830B (en) * | 2017-12-13 | 2019-06-11 | 葡萄王生技股份有限公司 | An active substance ofmorchella, its use and a composition thereof for improving the reproductive function |
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| CN116173089B (en) * | 2023-03-15 | 2024-05-24 | 曲阜师范大学 | Application of Morchella fermentation epimedium extract in enhancing macrophage activity and anti-tumor activity |
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| CN103550827A (en) * | 2013-10-31 | 2014-02-05 | 江南大学 | Preparation method and application of edible and medicinal fungus nanofilm |
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