KR101855821B1 - Composition for relieving of menopausal symptoms and improving blood circulation - Google Patents

Abstract

The present invention relates to a health food composition for relieving menopausal symptoms of women and improving blood circulation, which is obtained by adding a mixture including 4 kg of onions, 1,200 g of red ginseng, 200 g of Eucommia ulmoides, 200 g of Achyranthes aspera, 100 g of Angelica gigas, 100 g of Rehmannia glutinosa, 200 g of Paeonia lactiflora, 200 g of Ligusticum striatum, 200 g of Lycium chinense fruit, and 150 g of Cornus officinalis fruit to 20 L of water, and extracting the mixture for 48 hours at 90°C.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a composition for relieving menopausal symptoms and improving blood circulation in women,

The present invention relates to a health food composition for improving female menopausal symptoms and improving blood circulation. More particularly, the present invention relates to an improved composition for improving female climacteric symptoms and blood circulation which can produce a synergistic effect based on red ginseng, ≪ / RTI >

The term "climacteric" refers to a type of endocrine syndrome that is characterized by a general and gradual decrease in ovarian function, resulting in a decrease in physiological function and sexual function. The term "climacteric" refers to a period of menopause which is a permanent stoppage of menstruation (menopause) will come. Postmenopausal women may have acute chronic symptoms due to changes in hormones, such as decreased estrogen production, follicular stimulating hormone (FSH), and elevated luteininzing hormone (LH). That is, the initial symptoms may include vasomotor symptoms such as hot flush and night sweat, psychological symptoms such as anxiety, loss of concentration, and depression, and within a few years after menopause There may be cases of osteoporosis, cardiovascular and cerebrovascular disease after menopausal years and menopausal and epidermal manifestations.

Hormone replacement therapy and non-steroid therapy have been developed to improve women's menopausal symptoms. Among them, estrogen replacement therapy is known to be the most effective method. However, the use of long-term medicines according to the above-mentioned therapeutic regimen can cause endometrial cancer, breast cancer, hypertension, thrombosis, gallbladder stone, etc., and also may cause mild bleeding and ovarian hyperstimulation, There is a problem that it can not be taken without prescription.

In order to overcome the problems caused by the therapeutic treatment of these drugs, development of an agent for improving the symptoms of female menopausal symptoms based on natural herbal medicine has been attempted, and it is known that red ginseng is useful for the improvement of various menopausal symptoms (The Society for Korean Ginseng 1990; 20p - 24p)

In addition, it is known that the herbal medicine, which has been introduced from ancient times, is effective for the menopausal symptom of women, and the clinical example of the combination treatment of Dangguo peach acid and red ginseng (The Ginseng Review, 1991; vol 18: 95p-97p).

Korean Patent Laid-Open Publication No. 2003-0023297 discloses a composition for improving menopausal syndrome containing soybean extract and red ginseng extract containing isoflavin. Particularly, the inventors of the present invention have found that red ginseng, isoflavone, The Korean Society of Postmenopausal Sciences, Journal of the Korean Society of Menopause, Vol. 8, No. 1, 2002. 3. p46-p58)

On the other hand, the prior art based on the above-mentioned herbal medicines can reduce side effects rather than therapeutic treatment with drugs, but the medicinal effect for improving the symptoms of women's menopause is insignificant. Therefore, Development of a functional food has been attempted so as to effectively prevent women's menopausal symptoms without fear of drug poisoning or side effects while preventing imbalance.

In addition, the circulation of blood (blood circulation around the heart around the blood vessels in our body to supply oxygen to the body tissues, carbon dioxide emissions, nutrients, and release metabolism, It transports hormones from various endocrine glands to regulate the functions of specific organs, as well as to regulate pathogens, regulate body temperature, control osmotic pressure, and regulate moisture.

The blood vessels consist of camellias, capillaries, and veins. The artery is composed of an outer membrane composed of an external elastic plate and connective tissue, a middle membrane containing many smooth muscles and a large number of elastic fibers therein, an inner membrane of the innermost endothelial cells, a connective tissue surrounding the inner membrane, Lt; / RTI > The capillary blood vessels are connected by a small artery and a small artery. They have a narrow net shape and are thin tubes with a diameter of 0.008-0.02mm. They are passed through 1 or 2 lines of red blood cells and are not visible to the naked eye. And nutrients are sent into the tissues and the CO ₂ or waste produced by the tissues enters the blood vessels. The outer membrane of the vein is relatively thick, the inner membrane and the middle membrane are thin, and there is a valve to prevent backflow because there is no pressure and there is a risk of backflow in the vein lower than the heart due to weaker blood flow than other blood vessels.

Blood circulation disorder means that blood vessels lose their elasticity and cholesterol is deposited on the inner wall to narrow blood vessel lumen, resulting in poor blood circulation. Stroke [paralysis, wind], which is considered to be one of the most typical circulatory diseases, is a cerebrovascular disorder or clogging of blood clots or fat. Stroke, along with cancer and heart disease, is one of the three causes of death in Koreans. Stroke is caused by hemorrhagic stroke caused by pressure rupture of the wall of the cerebral artery due to pressure and formation of hematoma inside the brain tissue and peripheral cerebral tissue, and a part of the cerebral artery becomes narrowed or blocked, oxygen and nutrients are supplied through the artery, There are two types of ischemic stroke. Hemorrhagic stroke is classified into two categories: cerebral hemorrhage and subarachnoid hemorrhage. Ischemic stroke is further divided into cerebral infarction and transient ischemic attack.

The more common symptoms that lead to hemorrhage are hypertension and atherosclerosis. Hypertension refers to a disorder in which the systolic blood pressure is greater than 140 or the diastolic blood pressure is greater than 90. It is classified as severe hypertension when the diastolic blood pressure is 90 to 104, severe hypertension when the blood pressure is 105 to 110, and severe hypertension when the blood pressure is 110 or more. Ninety percent of patients with total hypertension are baseline (primary, primary) hypertension whose cause is unknown, and the most obvious cause is secondary (secondary) hypertension. Blood pressure increases with age and has a high genetic tendency. It is caused by abrupt personality, obesity, high salt intake, mental stress, smoking, drinking, kidney disease, pheochromocytoma, oral contraceptive use, primary hyperaldosteronism Hypertension occurs.

Arteriosclerosis is a phenomenon in which arterial walls are hardened, elasticity is reduced, fat is trapped on the inner surface, and abnormal tissue grows to narrow the inner diameter. Some of the atherosclerosis phenomenon is aging phenomenon. As the aging progresses, the incidence of arteriosclerosis increases, and at the same time, many organs are invaded. If this phenomenon occurs in the cerebral blood vessels, it becomes a stroke. In addition, heart disease and diabetes are closely related to hypertension and atherosclerosis.

The mechanism of the stiffness is not clear yet, but excessive stiffness of the nerve, muscle fatigue and autonomic dystonia cause excessive shrinkage of the peripheral blood vessels, blood circulation in the muscles, and congestion. Therefore, it is effective to improve blood circulation in order to eliminate the muscle rigidity phenomenon. It is difficult to obtain a desired effect as a therapeutic method such as massage, warm bath treatment, use of a poultice, electric stimulation and drug administration, or it is troublesome that some of them have to go to a hospital for professional treatment.

1. Korean Patent Publication No. 2003-0023297 2. Korean Patent Publication No. 2007-0070292

Accordingly, an object of the present invention is to provide a health food composition for improving female menopausal symptoms and promoting blood circulation.

According to an aspect of the present invention,

A mixture prepared by adding 4 kg of onion, 1,200 g of red ginseng, 200 g of persimmon, 200 g of horse mackerel, 100 g of Angelica gigas, 100 g of Ganoderma lucidum, 100 g of Ganoderma lucidum, 100 g of Ganoderma lucidum, 200 g of Ganoderma lucidum, 200 g of Gugija and 150 g of Sansui oil to 20 ℓ of water is extracted at 90 캜 for 48 hours A health food composition for improving female menopausal symptoms and promoting blood circulation.

In a health food composition for improvement of female climacteric symptoms and improvement of blood circulation according to the present invention, a sweet potato juice and a chicory juice are mixed at a weight ratio of 1: 1, and a starch is decomposed by adding a-amylase Next Aspergillus oryzae var. oryzae fungus is inoculated in the juice by 10% by weight, fermented at 50 ° C for 48 hours, added with 5ℓ of the filtered fermentation broth, and then fermented at 50 ° C for 48 hours, followed by extraction.

In the health food composition for improvement of female menopausal symptoms and improvement of blood circulation according to the present invention, the water is preferably hydrogenated water.

The composition according to the present invention is an excellent health food composition for middle-aged women because it is very useful and effective for improving female menopausal symptoms and improving blood circulation.

Hereinafter, the present invention will be described in detail.

Basically,

A mixture prepared by adding 4 kg of onion, 1,200 g of red ginseng, 200 g of persimmon, 200 g of horse mackerel, 100 g of Angelica gigas, 100 g of Ganoderma lucidum, 100 g of Ganoderma lucidum, 100 g of Ganoderma lucidum, 200 g of Ganoderma lucidum, 200 g of Gugija and 150 g of Sansui oil to 20 ℓ of water is extracted at 90 캜 for 48 hours A health food composition for improving female menopausal symptoms and promoting blood circulation.

The onion used in the present invention is presumed to be originated in West Asia or the Mediterranean coast, but it is not certain because wild type was not found yet. The cultivation history is so long that there are records that ancient Egyptian burial mounds around 3000 BC fed garlic and onion to pyramid workers, and grew in Greece from the 7th to 8th centuries BC. Scale stem is somewhat different according to varieties, but it has a flat round or round shape. It has thin purple color (semitransparent like translucent film) on its surface. Its inner scales are thick, This is fascinating. Leaves are hollow cylinders, dark green, dry when flowers are bloomed, and sculpted at the bottom. The flower blooms in September, and the flower stalk which comes out from the leaf forms a mountain inflorescence, and many numbers are round like a ball. The flower stalks are cylindrical and have a height of 50 ~ 100cm and the lower part is swollen with 2 ~ 3 leaves under it. The horns are divided into 6 pieces, and the split pieces are basically shaped like inverted eggs and spread horizontally. There are six stamens, of which there are three on each side under the operating table, and one pistil. The varieties are divided into a round shape of the stem of the scales, a flat round shape, a red color of the scales stem, a yellow one, and a white one. It is also divided into sweet onion and spicy onion depending on taste. Generally, edible onion varieties are four varieties of yellow onion, red onion, white onion and small onion. The harvest is mainly from June to July when the leaves fall down and have a little green color. Some of the leaves of the scales are picked before the leaves are edited. Onion is mainly used for edible scales. The unique odor from scales is due to compounds such as disulfide propyl sulfide and allyl sulfide. It physiologically promotes the secretion of digestive juices and has effects such as excitement, sweating, and diuretic. In addition, the scales stem contains various vitamins and minerals such as calcium and phosphoric acid, and it has action to remove harmful substances in blood. Scale stalk is used in salads, soups, and meat dishes, and is used as a spice for various dishes. The leaf contains 5,000 IU of vitamin A, 45 mg of vitamin C, 80 mg of calcium, 24 mg of magnesium, and 220 mg of potassium in 100 g of leaves. In the present invention, the onion means a stem of a scales including a shell.

The red ginseng used in the present invention refers to dried red ginseng by steaming ginseng, and the ginseng refers to the roots of the ginseng and ginseng plants. It is called as Korean Ginseng (Korean peninsula), American Sampler (USA and Canada), Jeollanam (China), Jangseum Sam (Japan) according to the cultivation area. According to the first processing method of maintaining the original shape of ginseng, White ginseng, sugar, and sesame seeds. Research on ginseng began by Garriques of the United States. Garriques separated the amorphous saponin mixture from ginseng in 1854 and named it panaquilon. Shibada and Tanaka (1963, 1966) in Japan in the 1960s separated 12 individual saponin components (ginsenosides) from Korean ginseng and revealed their chemical structure And it was possible to study the pharmacological effects of ginseng by single components. Korean ginseng (Panax ginseng C.A. Meyer) has been widely used for promotion of health in Korea, China, and Japan. The effective components of ginseng are known to be significantly different depending on the type of ginseng, root area, harvest age, harvesting time, and manufacturing method. The ginseng root is generally known to have a high sugar content in low-grade roots and a high saponin content in high roots . In addition, it is known that there is a difference between crude saponin content and ginsenoside type between red ginseng and white ginseng steamed with steam. In general, crude saponin is reported to be 10 to 15% or more crude saponin and 3 to 5% in fuselage. In other words, crude saponin contains about 13% in the fine root, 6.5% in the root, and 4% in the fuselage, and the non-saponin active ingredient is contained in the body much more than the fine root. The 'red ginseng' used in health functional foods is ginseng (Panax ginseng C.A. Meyer) as a raw material and steamed or otherwise steamed the uncooked ginseng to be boiled and dried. It should be powdered, extracted with water or alcohol, concentrated or fermented to make it suitable for edible use, and the sum of ginsenosides Rg1 and Rb1 should be controlled to be 0.8 to 34 mg / g. The standard of ginsenosides was as follows: Powder Rg1: 2.0-4.0 mg / g, Rb1: 4.0-12.0 mg / g / water extract Rg1: 0.3-6.0 mg / g, Rb1: 0.5-10.0 mg / g / Extract Rg1: 0.3 to 13.0 mg / g, Rb1: 0.5 to 21.0 dmg / g). Ginseng roots used as raw materials should conform to the 'Ginseng Industrial Act' and should not be used for more than 4 years old. Chungsam, Seomyeom, Sampy, Ginseng roots can not be used. Red ginseng has been recognized as "functional for restoring fatigue", "improving immunity" and "helping blood flow through inhibition of platelet aggregation". In the West, the function of ginseng is sometimes referred to as ergogenic. Ergogenic is a synonym for Ergo and Genetics in Greek, meaning that it usually improves the potential to work. Bahrke et al. (2000) analyzed the ergogenic effects of ginseng on exercise, Stress response effect, cognitive ability, and psychological stability. As a result of examining the functional data of ginseng, it can be concluded that ginseng and red ginseng can be recognized only by the recovery effect on physical fatigue, and that the function concerning stress and psychological stability is not sufficiently studied in the human body Respectively. In this study, the effects of ginseng on corticotropin (corticotropin, ACTH) and cortisol in experimental animals and humans were investigated by the method of Popov et al. (1973), Hu et al. (1976), Li et al. (1973), Perry et al. (1980) and Baranov et al. And that the body's ability to resist external stimuli such as increased secretion of hormones were reported. In fact, Liang et al. (2005) observed that the average blood pressure decreased and the maximum oxygen uptake and exercise duration increased during the exercise period by taking 1350 mg of ginseng extract per day for 29 healthy people aged 20 to 35 years, Marasco et al. (1996) found that the intake of 200 mg of ginseng extract for 12 weeks increased the quality of life associated with fatigue recovery in 501 healthy subjects. Cherdrungsi et al. (1995) reported that the intake of 300 mg of ginseng extract for eight weeks to 45 college students increased maximum oxygen uptake and increased leg strength compared to the control group. Kim et al. (2004) reported that red ginseng extract ingested 50 mg / kg daily for 3 weeks and continued running in a treadmill with a slope, the recovery of creatinine kinase level in the blood could be quicker to recover after muscle injury. In addition, the results of analyzing the other body application tests revealed that the ingestion of dried ginseng more than 2g / day for more than 8 weeks confirmed significant fatigue recovery function (Popov et al., 1973; Revers et al., 1976; Dorling et al. Forgo et al., 1980; Forgo et al., 1981; Forgo et al., 1982). However, no improvement was observed in tests consisting of low dose, short duration administration, small number of subjects, and the like. In Allen et al. (1998) who consumed 200 mg of ginseng extract for three weeks per day in 28 healthy volunteers with an average age of 23 years, no significant improvement was observed in exercise time and blood lactate concentration. Lifton et al. (1997), Engels et al. (1995), Engels et al. (1996) and Engels et al. Therefore, it can be said that the ginseng extract improves muscle strength and aerobic exercise volume when appropriate conditions are met. Ginseng as an immunoregulatory effect is classified as adaptogen or immunostimulator. "Adaptogen" refers to a substance that makes our body resistant to physiological or biological stimuli, while "immunostimulant" refers to a substance that activates a nonspecific defense against a foreign body such as infectious agents of the body. (1990) observed that the ingestion of 200 mg of ginseng extract for 8 weeks resulted in an increase in the phagocytic activity of PBMC. In a 1996 study, 227 patients received 100 mg / day for 12 weeks, Gerald et al. (2005) found that 400 mg of the extract made from American ginseng was consumed in 323 patients with weak immunity for 4 months, reducing the frequency of colds. (1998) reported that patients who underwent digestive organs surgery received red ginseng at a dose of 4,500 mg per day for six months The number of T cells, NK cells, and number of activated T cells were significantly increased after immunocytochemical examinations. Yu et al. (2006) treated red ginseng extract with platelets in this animal, Dose-dependent inhibition of platelet aggregation induced by substances (collagen, arachidonic acid, thrombin, etc.), and did not affect APTT (Proportional Thromboplastin Time) or PT (Prothrombin Time) In addition, Park et al. (1993) reported that panaxadiol saponins in red ginseng reduced TXA2 production by thrombin in normal adult platelets. . In the control group, the platelet aggregation was significantly decreased and the APTT was not significantly different In the study of Lee, Jung-Hee, et al. (1998) comparing red ginseng products to those who did not take long-term ingestion for 4 to 5 years, platelet aggregation response in the long-term intake group decreased significantly and blood coagulation time Respectively.

The diapause used in the present invention is a drug used to dry the bark of Eucommia ulmoides Oliver, which is a name given to a person who once eats DuPont and eats it, , And the name tsun (仙 仙) comes from the same story. Quercus mongolica is often called cotton because it has a lot of transparent fibers like silk in leaves and bark. The taste of this medicine is very sweet and its quality is warm. There is an effect of lowering blood pressure by treating low back pain due to lack of function of liver (kidney), knee pain, numbness of body, coldness of lower abdomen, urinary frequency, early anxiety, uterine bleeding. Antihypertensive action, anti-aging, cholesterol lowering, anti-inflammation, sedation, pain relief, immune control, blood clotting, uterine contraction, antiallergic and antibacterial activity have been reported. The outer surface is gray or dark gray. There are many cell wrinkles, small pores in the skin, and the inner surface is smooth and dark brown. When broken, a thin, white fiber yarn with tenacity is formed. Duchong 's tinnitus is 仲 中, 四 仲, 四 仙, 綿, masseon, and 運 皮.

The worm used in the present invention refers to the root of Achyranthes japonica Nakai or Achyranthes bidentata Blume in Korea and in Acyranthes bidentata Blume (牛膝) and Achyranthes fauriei H. Lev. & Vaniot). China recognizes only the Achyranthes bidentata Blume (牛 膝). There was a doctor who treated old bone or muscle disease, liver and kidney disease patients well, and decided to try to find a true disciple who was his successor. He decided to stay at the disciples' house with a fleeting pattern and watch their attitude. As a result, only the youngest disciple treated this moneyless mentally. The senator who applauded him told him the efficacy of herbal medicine and said, "He will save many people with this medicine because it is medicine to treat diseases of liver and kidney as well as bones and muscles." The disciples used this herb as a master 's will and became a name, and the appearance of the herb' s knuckles was like a cow 's knee and called' 牛 '. This medicine has little odor and is mucoid. The taste is a little bit spicy, and the quality is flat without any bias. If you use raw whiskey, you can eliminate the ejaculation and boils, and if you grind it, you will see the liver and the gods and strengthen the muscles and skeleton. It removes eosinophilia, and it is used for physiological impoverishment, postpartum abdominal pain. It replenishes bone marrow, it is used for arthritis with good sound, and it treats the mouth and tongue rash caused by the diarrhea. The pharmacological effects of uterine stimulation, cholesterol lowering, diuretic action, hypoglycemic action, and liver function improvement have been reported. Appearance is a long, long, circumferential circular root, or a circular root with a side root. The root head is attached or removed with a little rhizome. The roots are usually rod-shaped or slightly curved, and the outer surface is yellow or yellowish brown with many vertical wrinkles and sparse ridges. Other names include 牛 莖, hundredfold, mountain prefecture, 節节 菜, and 鷄 膠 骨. Especially in China, it is said that the mountain of Huanggang, It is called "虚 牛膝".

The Angelica gigas Nakai used in the present invention refers to the dried root of Angelica gigas Nakai in Korea and the mountain type and Angelica sinensis (Oliv.) Diels in China. In Japan, the roots of Angelica acutiloba (Siebold. & Zucc.) Kitag. Or Angelica acutiloba (Siebold. & Zucc.) Kitag. Var. Sugiyamae Hikino) are dried and used. It is said that it is named 'Dangwi (当归)' with the intention of wanting to return. This is because the belief that long ago, in China, the wife put Angelica in her arms while worrying about her husband going to the battlefield, believing that when she was full of energy on the battlefield, her energy could be recovered again after eating Angelicae. Sometimes it is said to be named after "When you take this medicine, your blood will return to its original position." This medicinal herb is warm and tastes sweet and spicy. In general, Chrysanthemum angustifolia is stronger than Chinese Angelica and why it is sweet and has a pungent taste. The efficacy of angiosperms is due to the blood-producing (blood-clotting) action of producing blood when blood is scarce. Chinese Angelica, why Angelica, made from the root of Angelica gigas, is excellent in blood circulation. However, Angelica root, made from the root of Angelica gigas, has better anticancer effect and blood pressure lowering effect than antihypertensive action. Pharmacologically, Angelica promotes the blood flow of the coronary arteries and stimulates red blood cell production. Chinese angelica has a yellowish brown color in the skin of the medicinal material. Angelica and Angelica are dark brown. The cross section of the medicinal material shows clear yellowish yellow and yellowish color of Chinese angelica, but why the angelica is yellowish white or grayish white, and the angelica is dark yellow or milky white. In addition, in the case of Chinese Angelica gigas, the oil component can be observed in the cross section of the medicinal material compared to Angelica gigas and Angelica gigas. It is also called Chongryounggi, Chungsangganggu, and Chrysanthemum chinensis in Chinese. It is known that Chinese angelica (chrysanthemum) It is also called "仙 仙", and it is also called "귀 귀 일".

As used in the present invention, Sukjihwang is a medicinal herb that is steamed and dried by the roots of Zhiwang (地 黄). Sichuan is a medicinal plant of perennial plant attached to the ginseng root, and its roots are used as medicines in one medicine. Especially in Sukjipguk, it is said that it is made by repeating 9 times of steaming and drying after soaking in alcohol. It has a bitter taste with a bitter taste, but it has a warm temperament, and it replenishes its blood and replenishes its essence (a substance that is fundamental to life and activity). It causes back and knee pain, sore symptoms, menstrual disorder, dizziness It has the efficacy to cure the head and darken the head. Sukjipang is the main medicinal material of Sangmangtang, and it is used for symptoms such as inner heat, sore throat, and thirst which are manifested by weakness of various chronic diseases. Samtang is widely used for excessive bleeding, weakness and dizziness caused by women's birth or menstruation. It has been effective in treating Huhdam (虛 痰) for a long time and drank for a long time by tea. It was used with cough and asthma in combination with gyeongryeong (茯 笭) and half-summer (half summer). In addition, boiled pork with broth is effective when taking habitual constipation. It has a lot of nutrients and it is greasy. If you take it for a long time, it causes digestive disorder and causes side effects such as diarrhea and repetition. Therefore, it should be used with caution in patients with no appetite, no digestion, and diarrhea.

The peony used in the present invention refers to the root of a perennial herbaceous plant belonging to the family Ranunculaceae, There are a variety of varieties, such as peanuts, herbal medicines, herbal medicines, and medicines. The ingredient is a glycoside containing paeoniflorin and alkaloid paeonine, and tannin, resin and benzoic acid. The pharmacological actions of the rats weakened the contraction of the gastrointestinal tract and uterine smooth muscle, and showed a gastric (spasmodic) effect in the intestinal tract of the rabbit. The glycoside component inhibits the central nervous system. In addition, it has antimicrobial action, and it inhibits the development of Staphylococcus aureus, Disease, hemolytic streptococcus, and pneumococcus. The weakness is cold, the taste is bitter and bitter. It is effective when there is abdominal pain, diarrhea and abdominal pain due to gastroenteritis and gastrointestinal spastic pain, and it is effective even when there is abdominal pain after abdominal pain and diarrhea. It shows the efficacy of blood, pain, and blood transfusion in the menstrual irregularity and uterine bleeding. It is also used for chronic hepatitis and is also used for the pain of the liver. In addition, muscle spasms of the arms and legs caused by anemia, especially epigastric seizures, have epilepsy and analgesic effects. It belongs to medicine which is widely used in oriental medicine, and it is used for anemia in civilian. If the fever is severe in the postpartum period, do not take it. A typical prescription is peony liquorice (藥药 甘草 汤).

As used in the present invention, it is a perennial plant of perennials. It is cultivated as a medicinal plant. Leaves are bifurcated in two thirds, with lanceolate lanceolate and somewhat deep sawtooth. It is 30 ~ 60cm in height, hollow inside and branch slightly. Leaves are alternate, two-folded three-queen-folded compound leaf, and the forked pieces are egg-shaped, with a slightly deep sawtooth. The leaves of the root and the bottom have long petiole, and the lower part forms a sheath, wrapping the stem. Flowers bloom from August to September, white and double-inflorescence. There are 5 petals and the inside is dry. There are 5 stamens and 1 pistil. The guns and the guns are 5 ~ 6 each in the shape of a line. The fruit is open but not mature. The nodules in the ground are like a lump of 5-10cm in length and 3-5cm in diameter and have a strong smell. It has efficacy for jeong, anal and tongue, and is used to treat headache, anemia, and women's diseases. Remove the leaves and stems from September to November, remove the stems, and dry them in the sun, then use 3 to 6g dalyeoseo, or use as a pill or powder.

As used in the present invention, the goji is a fruit of the gadfly tree belonging to the gadget family. The gadfly tree is a deciduous broad-leaved shrub (broad leaf bifurcated tree) with a stem of about 1 to 1.5 m in length, There are no thorns with small branches, but there are no thorns. The leaves have no hairs, and they are alternate phyllotaxis, ovate or ovate lanceolate, with pointed end and petiole about 1㎝. In June-September, purple flowers bloom on the sides of leaves with 1 to 4 blooms, corolla (corolla) is usually bell-shaped (like bell-shaped bell) and the end is divided into five branches . The fruit is a round or elliptical berry (fruit with lots of flesh and water and seeds) and ripens red in August and September. The length is 10 mm and the diameter is about 5 mm. It is sweet at first and bitter afterwards. When it is dry, it crumble on the outside, and there are many seeds inside. The seeds are flat, kidney-shaped, about 2mm in diameter and yellowish white. Because the shape and color of the fruit is pretty and small, it is said to be the "좃좃 木 夏" in ancient times. Currently, Cheongyang County in Chungcheongnam-do is the distribution center in Korea. Ingredients include betaine, zeazanthin, carotene, thiamine, and vitamins A, B1, B2, and C. Animal studies have shown that beta-linolenic acid is one of the in vivo metabolites of lipid (parent lipid). It inhibits the accumulation of fat in the liver, promotes hepatocyte development, and lowers blood pressure. Medicinal (medicinal) is mediocre and not poisonous. Efficacy of chronic hepatitis, liver cirrhosis, etc., when the inflammation is removed and the function is activated. Generally, the reproductive function is weak, and the back and the knee are sore, and it is effective for the symptoms such as the oiliness, the fatigue, and the fever. It is effective for the reduction of visual acuity due to ophthalmologic diseases and it is applied to the early symptoms of cataract in the elderly. Long-term use of gojija lighter and stronger energy, strengthening the legs and waist strength and has the effect of inhibiting the aging of cells. In the private sector, it is used as 枸杞 茶 or 기 酒. Do not administer to people with fever. In one room, it is used as a tonic, and as a typical prescription, there is a Kigyu Hwanghwang (杞 菊 地 黄 丸).

The myrrh oil used in the present invention is the fruit of the stratum corneum and the myrtle tree. It is oval-shaped nucleus and is green at first, but ripens reddish from October to October. Seeds are long oval and have ridges. It has a bitter sweetness and strong acidity. It is harvested after the frost fall in mid-October. The flesh is separated from the seeds and the meat is used as a material for sake, tea and Chinese medicine. The pulp contains the glycosides such as cornin, Morroniside, Loganin, tannin and saponin and organic acids such as wine, malic acid and tartaric acid. In addition, it contains vitamin A and a large amount of sugars. Seeds include palmitic acid, oleic acid, linoleic acid and the like. Among the components, cornin is known to have an excitatory action of parasympathetic nerves. From the past, the pulp was weakened in one batch. According to the "Dongbibogam" and the "Fragrant Bulgari", it is said that it has effects such as strengthening of 阴 阴, 肾 精 and 肾气, and convergence. It is used as a medicinal product for headache, tinnitus, sea water, fever and menstrual overuse. It is also used for folk remedies such as cold sweat and enuresis. There are effects such as stopping sweat, consonance and so on. Sansui is native to Korea and China, and is planted in the middle of South Korea. In Korea, Shandong, Gyeonggi Province, Gyeonggi Province, Gyeonggi Province, and Gyeongsangbukdo, Yusung Gun, and other local products are shipped every year.

The content of each component and the temperature and time of extraction, as described above, in the various tests of the present inventors prescribe optimal contents for improvement of female menopausal symptoms and promotion of blood circulation.

In addition, in order to sufficiently achieve the desired function of the present invention even though it is manufactured as a hot water export by mixing with water as described above, in order to further improve effects such as improvement of women's menopausal symptoms and improvement of blood circulation, can do.

After washing and cutting the potatoes, the potato juice was poured using an untreated juice to make a potato juice. Then, the chicory was washed, and then the juice was poured using a green juice to make a chicory juice. The juice was mixed at a weight ratio of 1: , The insoluble matter is removed by centrifuging the juice solution, and 1% by weight of a-amylase is added to the juice solution by centrifugation to decompose the starch.

Thereafter, the starch-decomposed juice was sterilized through a sterilizer, and the sterilized juice was centrifuged to obtain only the supernatant. Aspergillus oryzae var. oryzae fungus was inoculated at 10% by weight and fermented at 50 ° C for 48 hours to produce Aspergillus oryzae var. oryzae (KCTC No. 6596) Produces a juice solution in which fungi have been cultured.

Subsequently, 5 L of the fermentation broth obtained by filtering the fermented juice solution was added to a mixture of water and a pharmaceutical agent, and the fermentation was further continued at 50 ° C for 48 hours, followed by hot water extraction to prepare a health food composition according to the present invention .

In order to increase the efficacy of the health food composition according to the present invention, the water used may be hydrogenated water. The hydrogenated water of the present invention may be used in a method such as magnetization treatment, ultrasonic treatment, ore treatment, mineral treatment, Lt; / RTI > Among these methods, electrolysis method is mainly used, and hydrogen water produced by electrolysis is referred to as electrolytic hydrogen water. Electrolytic hydrogen water is referred to as alkaline ion water or hydrogen rich water, and it is used for water, beauty, industrial and agricultural use . Specifically, electrolytic water has an effect on dermatitis such as atopic dermatitis, skin whitening, aging, lifestyle-related diseases, and can be used in cosmetics with anti-aging and moisturizing effects, and has excellent effects in long-term preservation of foods.

When the above-mentioned water is used, the efficacy of the health food composition according to the present invention can be remarkably increased.

Hereinafter, the present invention will be described in detail with reference to examples.

< Example  One; Preparation of the composition according to the present invention &gt;

A mixture of 4 kg of onion, 1200 g of red ginseng, 200 g of ginseng, 200 g of Ganoderma lucidum, 100 g of Angelica gigas, 100 g of Ganoderma lucidum, 100 g of Ganoderma lucidum, 100 g of Ganoderma lucidum, 200 g of Ganoderma lucidum, 200 g of Gugija and 150 g of corn oil were added to 20 ℓ of water, A composition was prepared.

< Example  2: Preparation of composition according to the present invention &gt;

After washing and cutting the potatoes, the potato juice was poured using an untreated juice to make a potato juice. Then, the chicory was washed, and then the juice was poured using a green juice to make a chicory juice. The juice was mixed at a weight ratio of 1: And the insoluble matter was removed by centrifuging the juice solution. The starch was decomposed by adding 1 wt% of a-amylase to the juice solution by centrifugation. Thereafter, the starch-decomposed juice was sterilized through a sterilizer, and the sterilized juice was centrifuged to obtain only the supernatant. Aspergillus oryzae var. oryzae fungus was inoculated at 10% by weight and fermented at 50 ° C for 48 hours to produce Aspergillus oryzae var. oryzae (KCTC No. 6596) mold juice was cultured. Then, 5 liters of the fermentation broth filtered through the fermentation juice was added to the mixture of water and the pharmaceutical agent of Example 1, followed by further fermentation at 50 DEG C for 48 hours.

The fermented mixture was extracted at 90 DEG C for 48 hours and filtered to prepare a composition according to the present invention.

< Example  3: Preparation of composition according to the present invention &gt;

The same procedure as in Example 1 was used except that water was used instead of purified water. Hydrophobic water was prepared by using a solvent dispenser (SHD-100) manufactured by Solbi Biomedical Dispenser.

< Example  4: Preparation of composition according to the present invention &gt;

The same procedure as in Example 3 was used except that water was used instead of purified water. Hydrophobic water was prepared by using a solvent dispenser (SHD-100) manufactured by Solbiomedical Dispenser.

< Comparative Example : Preparation of Comparative Composition &gt;

The composition to be used as a comparative example was prepared by extracting 3 kg of red ginseng, 200 g of red ginseng and 300 g of peony root in 20 L of purified water at the same temperature and time as in Example 1.

<Experimental Example 1: Experimental Effect of Blood Circulation Promotion>

In order to measure the vasodilating effect of the health food composition for promoting blood circulation according to the present invention, expansion effect on KCl-induced vasoconstriction was measured by physiography using the rats' lower limb artery.

As experimental animals, Sprague-Dawley rats weighing 20 ~ 25g were acclimated for more than 1 week in a constant temperature and humidity-maintained animal breeding room, The control group was fed with Ginkgo biloba extract and the experimental groups were dissolved in saline to give 0.14 mg per 250 g of body weight per day to the abdomen. Respectively.

The results of the expansion experiment for KCl 72.7 mM induced vasoconstriction are shown in Table 1 below.

Shrinkage (%) for 72.7 mM KCl Mean ±
Standard Deviation 1 time Episode 2 3rd time 4 times Ginkgo biloba extract 47.3 60.2 52.8 66.1 56.60 + - 7.14 Example 1 Composition 93.7 75.1 86.4 81.8 84.25 + - 6.78 Example 2 Composition 94.2 76.1 88.2 83.5 85.50 + - 7.25 Example 3 Composition 94.1 74.8 88.0 82.8 84.92 + 9.38 Example 4 Composition 96.7 85.2 92.4 87.5 90.45 ± 3.19 Comparative Example Composition 45.2 57.8 52.8 64.2 55.00 ± 6.21

As shown in Table 1, it was confirmed that the health food composition of the present invention against KCl 72.7 mM induced vasoconstriction had better vasodilating effect than Ginkgo biloba extract, whereas the comparative composition showed better vascular expansion than Ginkgo biloba extract Respectively. In addition, the composition according to the present invention was superior to the composition using hydrogen peroxide and the composition obtained by fermentation.

Experimental Example 2: Measurement of inhibitory effect on arteriosclerosis [

Ten male rats selected in Experimental Example 1 were group 1, and cholesterol 40 m / kg and cholacilliprole 3200 IU / kg were dissolved in olive oil at the same time, and they were orally administered once a day for 28 days to induce arteriosclerosis . Herein, Examples 1 to 4 and Comparative Example compositions were each post-treated for 7 days at a concentration of 0.250 g / kg. The treatment method was orally administered once a day, and only the same amount of physiological saline was orally administered to the control group in the same manner.

On the last day of the experiment, the control group and the experimental group were fasted for 12 hours and blood was drawn from the abdominal artery under anesthesia. The obtained blood was centrifuged at 3000 rpm for 15 minutes to collect non-hemolyzed serum. Then, the total cholesterol content and the content of HDL-cholesterol contained in total cholesterol were measured by an enzymatic method, and the content of triglyceride and calcium content Were each measured using a measurement kit. The experimental results are shown in Table 2 below.

Total cholesterol Triglyceride calcium Control group 73.8 ± 4.2 53.9 ± 4.02 20.7 ± 0.8 Example 1 Composition 72.1 ± 5.4 43.2 ± 3.78 17.4 ± 0.2 Example 2 Composition 70.5 ± 6.2 41.5 ± 8.01 16.2 ± 0.1 Example 3 Composition 70.2 ± 5.7 40.9 ± 9.18 15.9 ± 0.5 Example 4 Composition 68.4 ± 8.2 38.1 + - 2.54 14.1 ± 0.6 Comparative Example Composition 73.1 ± 9.1 45.1 ± 3.05 18.6 ± 1.4

The results are shown in Table 2. As shown in Table 2, the group administered with the composition of the present invention showed an excellent effect as compared with the control group.

< Experimental Example  3: 17? estradiol Concentration measurement experiment>

Five Sprague Dawley female rats at 21 days of age (average body weight: 50 g) were prepared for each group, and five rats at 5 to 6 months of age were also prepared for each group (average body weight: 350 g) to prepare the compositions of Examples 1 to 4 and Comparative Examples at 30 mg / kg body wt / day for 3 days.

The concentration of 17 [beta] estradiol in the blood before and 3 days after administration of the sample was measured. The average values of the results are shown in Table 3 below.

21-day old mouse 6 months old mouse Before administration (pg / ml) After administration (pg / ml) Before administration (pg / ml) After administration (pg / ml) Example 1 Composition 5.20 0.35 6.75 + - 0.69 6.51 + - 0.74 7.65 ± 0.55 Example 2 Composition 5.22 ± 0.31 6.89 + - 0.41 6.47 ± 0.37 7.97 + - 0.12 Example 3 Composition 5.21 + - 0.38 6.91 + 0.24 6.52 ± 0.72 7.97 + - 0.37 Example 4 Composition 5.23 ± 0.59 7.34 ± 0.27 6.51 ± 0.39 8.43 + - 0.59 Comparative Example Composition 5.20 ± 0.24 5.70 ± 0.35 6.52 ± 0.11 7.04 0.32

As shown in Table 3, it was confirmed that the total amount of the group administered with the composition of the present invention was significantly higher than that of the composition of the comparative example. In particular, the fermented example of the present invention showed more excellent effects, The use of hydrofluoric acid also showed a significant effect.

< Experimental Example  4: TRAP (an indicator of osteoporosis) Tartrate -resistant acid 포스화제 ) Effect on activity>

In this Experimental Example, effects of the compositions prepared in Examples 1 to 4 and Comparative Examples on the activity of TRAP (Tartrate-resistant acid phosphatase) were examined. Tartrate-resistant acid phosphatase (TRAP) is an indicator of osteoclast. Low activity of TRAP indicates that osteoclast differentiation is suppressed.

In order to differentiate MC3T3-E1 cells into osteoclasts, femoral bone marrow cells of 7 week old C57BL / 6 female mice were harvested and cultured in MC3T3-E1 cells in MEM medium (10% FBS, 100% U / ml penicillin and 100 g / ml streptomycin).

And MC3T3-E1 cells ^{(1.5 × 10 4 cells / well} ), bone marrow (bone marrow) cells ^{(5 × 10 5 cells / well} ) 10 to the seeding (seeding), and MEM culture medium in 24-well plate (well plate) ^{- 8} M 1,25 (OH) ₂ vitamin D ₃ , and 10 ^-7 M dexamethasone were treated at a concentration of 50 μg / ml in each of the samples (Examples 1 to 4, Comparative Example). The culture medium was changed every 3 days, and the cells were cultured for 7 days.

After 7 days of incubation, the cells were washed twice with phosphate buffered saline (PBS), the cells were scraped using a lysis buffer, sonicated at 10 second intervals Cell lysate was obtained 4 times.

TRAP activity measurement kit was purchased from Lifespan Biosciences, and ELISA kit was purchased and measured at 450 nm according to the manufacturer's method.

(1,25 (OH) ₂ vitamin D ₃ ') were treated as a normal group, and the control group was treated with 1,25 (OH) ₂ vitamin D ₃ , And the results are shown in Table 4 below. Significant differences between the experimental groups were analyzed using 'ANOVA' and significance was p <0.05.

TRAP (% of control) General group 69 ± 11.4 Control group 109.2 ± 2.86 Example 1 Composition 89.6 ± 4.28 Example 2 Composition 85.7 ± 3.24 Example 3 Composition 84.2 ± 2.74 Example 4 Composition 80.6 + 4.51 Comparative Example Composition 95.6 ± 3.43

As shown in Table 3, it was confirmed that the total amount of the group administered with the composition of the present invention was significantly lower than that of the control group and the comparative composition. In particular, the present invention was more effective in the fermentation of the present invention , And the use of hydrogen peroxide as an extraction solvent was also found to have a significant effect.

As described above, it can be seen that the composition according to the present invention exerts an excellent effect in improving female menopausal symptoms and promoting blood circulation.

Claims (3)

To the mixture of 4 kg of onion, 1200 g of red ginseng, 200 g of ginseng, 200 g of Ganoderma lucidum, 100 g of Ganoderma lucidum, 100 g of Ganoderma lucidum, 100 g of Ganoderma lucidum, 200 g of Ganoderma lucidum, 200 g of ganoderma lucidum, 200 g of Gugija and 150 g of corn oil were added to 20 ℓ of water, After mixing with the weight ratio, a-amylase was added to decompose the starch, and then Aspergillus oryzae var. The oryzae fungus was inoculated with 10% by weight of the starch in the digestion solution and fermented at 50 DEG C for 48 hours. Then, 5 L of the fermented filtrate was added and the fermented product fermented at 50 DEG C for 48 hours was extracted at 90 DEG C for 48 hours The composition according to claim 1 or 2, wherein the composition is a composition for improving the symptoms of female menopausal symptoms and improving blood circulation.
The health food composition according to claim 1, wherein the water is hydrogenated to improve female menopausal symptoms and improve blood circulation.
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