KR102243873B1 - Fermented pills for reducing and preventing premature dementia and manufacturing methods thereof - Google Patents

Abstract

The present invention relates to a fermented relief Aquilaria agallocha pill for alleviating and preventing early dementia and a manufacturing method thereof and, more specifically, to a fermented relief Aquilaria agallocha pill for alleviating and preventing early dementia with excellent effects to dementia, reduced bitter tastes and charcateristc flavors of herbal medicines and facilitation of storage and ingestion by kneading yeast, composite fermented powder and herbal medicine powder containing Aquilaria agallocha, Stachys sieboldii and Taraxacum platycarpum to an extracted concentrate obtained by decocting any one or more medicines selected from the group consisting of Acorus gramineus, Wolfiporia extensa, Polygala tenuifolia and Schizonepeta tenuifolia to mix and ferment the ingredients, and to a manufacturing method thereof.

Description

Fermented relief acupuncture for alleviation and prevention of early dementia and its manufacturing method {FERMENTED PILLS FOR REDUCING AND PREVENTING PREMATURE DEMENTIA AND MANUFACTURING METHODS THEREOF}

The present invention relates to a fermented relief acupuncture for the alleviation and prevention of early dementia, and a method for manufacturing the same, and more particularly, to an extract obtained by boiling a medicinal material effective for dementia, kneading herbal medicine powder, complex fermented powder and new grains to ferment By doing so, it relates to a fermented relief acupuncture for premature dementia alleviation and prevention and a method of manufacturing the same, which reduces bitter taste and peculiar aroma of herbal medicinal herbs while having excellent efficacy against dementia, and facilitates storage and intake.

Dementia is a wide range of brain damage diseases that affects daily life by maintaining a normal intellectual level during the growth phase, but by acquiring cognitive impairment and changes in personality. It has been commonly known as a senile disease that most of the people over 65 years of age, but even before the age of 65, cases of dementia symptoms appearing in the form of'early dementia' have been reported steadily. In addition, as it enters an aging society, dementia is emerging as a serious medical, social and economic problem.

As for the type of dementia, Alzheimer's dementia has the highest frequency in the whole, and dementia develops in the order of vascular dementia, Lewy body disease, Parkinson's disease, and Creutz-Yakov's disease, and multiple forms of dementia can appear in a single patient.

As a general herbal remedy for Alzheimer's-type dementia, there is donee cortex, which is known to function to maintain normal acetylcholine, a neurotransmitter that plays an important role in memory and cognitive functions in the brain.

However, in patients with advanced Alzheimer's disease, side effects such as indigestion and increased aggression have been reported as the dose increases for the Western Cortex treatment.

As a part of reducing the side effects of the herbal remedy, interest in herbal prescriptions formulated with herbal ingredients consisting of herbal ingredients is increasing, and in recent years, herbal prescriptions related to dementia have been gradually identified through scientific clinical trials.

As an example, prior art document 1 reports that ingredients useful for Parkinson's disease are included in Baekbokryeong, Baekjak, Jeon, Cheongung, Jogu, etc., and efforts are being made to develop pharmaceuticals in various formulations containing the above ingredients. .

On the other hand, in some reports, a formulation as a food is proposed along with access to prescription drugs including herbal ingredients.

Prior Art Literature 2 discloses a health drink that helps prevent dementia through an herbal extract obtained by mixing ginseng, cornus, quince, and schisandra into distilled water and then heating it in a hot water extractor.

In addition, prior art document 3 is a memory composed of an inner layer comprising musk powder, antler powder, angelica powder, and cheonsam powder, and an outer layer comprising at least one kind of Baekbokryong powder, Cassia tora powder and Astragalus powder formed on the outer surface of the inner layer. The public diagnosis team for improving learning ability is being launched.

The musk ingredient is obtained from musk powder, a secretion obtained by drying the musk gland of musk deer, and is a medicinal material mainly used as a cardiac or stimulant to clear the stomach and mind.

However, since the price of the musk ingredient is set at a high price and it is difficult to supply and demand, there is a limit to mass production by registering Gongjindan containing musk as a food product.

Therefore, research in which the musk component is replaced with aloes and applied as a food is in progress.In prior art document 4, in disclosing a conjugate composition containing aloes and a method for manufacturing the same, a law was made in which aloes were pulverized and immersed in an aqueous ethanol solution. And stacking the legally formulated medicinal material on an extraction cloth, mixing a solvent to prepare a medicinal material extract, and then concentrating the medicinal material extract and mixing it with sugars.

However, in order to prepare the herbal extract, it includes a first and second extraction step in which extraction is performed for a long time (up to 26 hours), and an ultrasonic extraction step between the first and second extraction steps. In addition, since a separate solvent extraction step and a sterilization step are included, there is an inconvenience of having to go through several steps in the process.

Accordingly, as a result of the present inventors trying to improve the conventional problems, if expensive musk has arousal and excitatory action in the process of searching for herbal ingredients, a relatively inexpensive yet soothing, stabilizing action can be used instead of acupuncture, acupuncture, Herbal medicine powder, complex fermented powder, and new grains containing Choseokjam and Pogongyeong are kneaded with extracts extracted from medicinal materials effective against dementia to provide fermented relief acupuncture after mixing and fermentation, and early dementia relief of the fermented relief acupuncture. And by confirming the excellent efficacy for prevention, the present invention was completed.

Republic of Korea Patent Registration No. 1610459 (2016.04.20 announcement) Republic of Korea Patent Registration No. 0744015 (announced on 2007.07.30) Korean Patent Registration No. 1974886 (announced on May 3, 2019) Korean Patent Registration No. 1888587 (announced on August 14, 2018)

An object of the present invention is to provide a fermented relief acupuncture group for alleviation and prevention of early dementia.

Another object of the present invention is to provide a method for preparing fermented relief acupuncture for early dementia alleviation and prevention.

In order to achieve the above object, the present invention is a herbal medicine powder, complex fermented powder containing acupuncture, choseokjam and pogongyeong in the extract obtained by using at least one or more medicinal materials selected from the group consisting of Seokchangpo, Baekbokshin, Wonji and Hyunggae. And it provides a fermented safe acupuncture group for relieving and preventing early dementia, which is mixed with new grains and reconstituted after fermentation.

Specifically, the extract concentrate is extracted from seokchangpo 20 to 40% by weight, baekbokshin 20 to 40% by weight, base paper 20 to 40% by weight, and mold number 5 to 10% by weight.

In addition, herbal medicinal powders include acupuncture, choseokjam and pogongyeong, cheonggukjang fermented powder, deer antler fermented concentrated powder, cornus milk, angelica, dermis, gilkyung, schisandra, sukjihwang, red ginseng, galgeun, bokryeong, gugija, creation, red guk, ginger, cheonmaro. Any one or more selected from the group consisting of may be further included.

In the fermented safe acupuncture group for alleviation and prevention of early dementia of the present invention, the compound fermented powder is one or more selected from the group consisting of yeast and Bacillus bacillus. At this time, the yeast is one or more selected from the group consisting of Saccharomyces, sp., Shizosaccharomyces, sp., and Klureromyces sp. .

In addition, the present invention is a first step of obtaining an extract concentrate using at least one or more medicinal materials selected from the group consisting of Seokchangpo, Baekbokshin, Wonji and Hyunggae; A second step of kneading and fermenting the herbal medicine powder, complex fermented powder and new grains containing acupuncture, choseokjam and pogongyeong in the extract concentrate; A third step of drying and pulverizing the fermented dough to obtain a fermented medicinal powder; And it provides a method for manufacturing a fermented relief acupuncture step comprising a fourth step of blending the fermented medicinal powder and honey.

In the production method of the present invention, the extract concentrate is extracted from 20 to 40% by weight of seokchangpo, 20 to 40% by weight of baekbokshin, 20 to 40% by weight of the base paper, and 5 to 10% by weight of the number of molds.

In addition, the extract may contain herbal medicine powder, and the herbal medicine powder is cheonggukjang fermented powder, antler fermented concentrated powder, cornus milk, angelica, dermis, gilgyeong, schisandra chinensis, sukjihwang, red ginseng, galgeun, bokryeong, gugija, jinja, red ginseng , Ginger, any one or more selected from the group consisting of cheonma is further mixed.

The complex fermented powder is any one or more selected from the group consisting of yeast and Bacillus bacillus. The yeast is any one or more selected from the group consisting of Saccharomyces, sp., Shizosaccharomyces, sp., and Klureromyces sp.

In addition, with respect to 100 parts by weight of the extract concentrate, 1 to 3 parts by weight of the complex fermented powder is mixed, and 10 to 30 parts by weight of new grains are mixed.

According to the manufacturing method of the present invention, the mixed fermentation is performed at 30 to 50° C. for 48 to 96 hours.

The fermented dough is dried and the pulverized fermented medicinal powder is pulverized into 180 to 220 particles.

Thereafter, 60 to 90% by weight of the fermented medicinal powder and 10 to 40% by weight of honey are blended to form a pill.

According to the present invention, a fermented relief acupuncture dan having an early dementia alleviation and prevention effect can be provided by kneading and fermenting herbal medicine powder, complex fermented powder, and new grains in the extract obtained by distilling a medicinal material effective for dementia.

In particular, acupuncture used as an effective medicine for dementia is economical as it can replace conventionally expensive musk, while musk has arousal and excitatory action, whereas acupuncture exhibits soothing and stabilizing effects, so that early dementia relief of the present invention And it is useful for fermented relief acupuncture dan having a preventive effect.

In addition, the present invention is a mixture of herbal ingredients, which are herbal ingredients By fermentation, it improves the active ingredient, reduces the bitter taste and peculiar aroma of herbal medicines, relieves the burden on the stomach, liver, and intestines, and provides fermented relief acupuncture with excellent storage and intake by adding appropriate amount of honey can do.

Hereinafter, the present invention will be described in detail.

The present invention is after fermentation by mixing the herbal medicine powder containing acupuncture, choseokjam and pogongyeong, complex fermented powder and new grains in the extract obtained using at least one or more medicinal materials selected from the group consisting of Seokchangpo, Baekbokshin, Wonji and Hyeonggaesu. Provides fermented safe acupuncture groups for alleviation and prevention of early dementia.

Specifically, the medicinal material used to obtain the extract of the present invention may include at least one or more selected from the group consisting of Seokchangpo, Baekbokshin, Wonji, and Hyeonggaesu.

Seokchangpo is the dried rhizome of Acorus gramineus , a perennial plant belonging to the Chunnamdae family. It is named because it grows naturally in the cracks of rocks in mountain valleys. It has a warm and spicy taste. Leaves and flowers have a unique scent, and the roots are mainly used for medicinal purposes.

Seokchangpo is known to brighten ears and eyes, cure forgetfulness, awaken the mind, and make the brain healthy. It was a major component of Chongmyeong-tang, traditionally used to treat neuropsychiatric diseases.

In particular, it has been used to treat diseases such as dementia by improving memory and cognitive ability. Among the main components of Seokchangpo, eugenol and beta-asarone block the influx of calcium from brain cells to protect brain nerves and help against dementia.

According to the thesis introduced in the Journal of the Korean Journal of Pharmaceutical Sciences Vol. 51, No. 6 463~468p (2007), the active ingredients of Seokchangpo are (E), (Z)-Asarone, Sekshon, and caryophyllene. Caryophyllene), humulene, and methyleugenol are all reported to be involved in memory enhancement.

Wonji (遠志) literally means a medicinal herb that retains its meaning for a long time. It is used for medicinal purposes by drying the root of Polygala tenuifolia Willd., a perennial herb belonging to the Wonji family. Wonji is also the main ingredient of Chongmyeongtang, and has been used to improve learning and memory.

Constituents of the base paper include polysaccharides, saponins, glycosides such as xanthone o-glycosides, polygalitol, and tenuigenen. These ingredients alleviate dementia, Parkinson's symptoms, protect nerve cells, and improve memory. In addition, it treats nervous stability, expectorance, and insomnia, and is also used as a tonic and gangrene.

Baekbokshin refers to the penetration of the roots through the sclerotia of Poria cocos Wolf , a parasitic plant on the root of a pine tree. Fortune is mainly used to calm the mind and clear the head. It is also used to resolve the symptoms of heart palpitations caused by nervousness, forgetfulness, oil wells, and swelling of the stomach and whole body. As pharmacological action, diuresis, antibacterial action, intestinal relaxation action, ulcer prevention effect, blood sugar lowering action, heart contraction increase, immunity enhancing action, anti-tumor action, etc. have been reported.

Hyeonggaesu is a flower of the lamiaceae plant Hyeonggae (Schizonepeta tenuifolia var. japonica Kitagawa ), and it is named because the flower has a spike shape. It has a bitter taste and is slightly warm. Among the essential oil ingredients, d-Menthene and limonene are contained, and these ingredients cause excellent bronchodilating action to alleviate asthma, so it is used clinically as a treatment for chronic bronchitis. In addition, it sedates and lowers body temperature.

In pharmacological experiments, it has been reported that Hyeonggaesu-tang has a mild antipyretic effect, a sweat secretion promoting effect, a rapid effect of peripheral blood circulation, a spasmodic effect, a digestive effect, and a hemostasis effect. In addition, it shows a strong antibacterial action against Staphylococcus aureus and diphtheria, and also shows certain inhibitory action against anthrax, streptococci, influenza, dysentery, Pseudomonas aeruginosa and Mycobacterium tuberculosis.

The extract concentrate according to an embodiment of the present invention is preferably extracted from seokchangpo 20 to 40% by weight, baekbokshin 20 to 40% by weight, base paper 20 to 40% by weight, and mold number 5 to 10% by weight.

By combining Seokchangpo, Baekbokshin, Wonji, and Hyeonggaesu, each having different effective ingredients for dementia, it is possible to present a comprehensive therapeutic effect for the dementia group with various causes and lesions. In addition, it is possible to increase the efficacy in relieving and preventing early dementia through the combination of the Seokchangpo, Baekbokshin, Wonji, and Hyeonggaesu. However, the composition and content of the medicinal material used according to the embodiment of the present invention are exemplary and are not limited thereto.

The herbal medicine powder according to the present invention is characterized by containing acupuncture, choseokjam and pogongyeong.

Here, aloes refers to a juniper that sinks in water as the bestial tree in which the resin of Aquilaria Crassna is deposited. The quality is determined by the degree of sinking in water, and the smaller the content of the component resin that is the core of acupuncture, the more it floats without sinking.

According to <Donguibogam>, it is recorded that acupuncture removes bad energy, calms the mind, and has a smooth circulation of energy.

Specifically, acupuncture includes agarosepyrol (Agarospirol) that relaxes the central nervous system and clears the head, agarofuran (Agarofuran) that stabilizes the central nervous system, and dehydrofukinone (Dehydrofukinone), which has an anticonvulsant effect. Terpineol is contained, through which it can calm and stabilize nerves, and improve memory and cognition.

In addition, acupuncture makes the body's energy go from head to toe to every corner, so if it is mixed with other medicinal materials, it is well delivered to the place where the medicinal effect is needed.

Recently, acupuncture has been found to have sedative, anti-tumor, and anti-cancer effects, and has been effective in Alzheimer's and Parkinson's disease in animal experiments, which has provided evidence that it can be applied to cerebrovascular diseases such as stroke and stroke. No. 2019-151547].

In particular, acupuncture used as an effective medicine for dementia is economical as it can replace conventionally expensive musk, while musk has an arousal and excitatory action, whereas acupuncture has a soothing and stabilizing action, so the early dementia alleviation of the present invention and It is useful for fermented relief acupuncture with preventive effect.

Choseokjam ( Stachys sieboldii MIQ. ) is the root of Seokjampul, belonging to the perennial of the genus Lamiaceae. Because the roots are silkworm-shaped, they are called cordyceps of plants.

It is widely distributed in mountains and fields of Korea, eastern Siberia, northeastern China, Japan, and Kamchatka Peninsula.

Choseokjam is rich in antioxidant, anti-aging, and anti-cancer properties. In particular, oriental medicine has been recognized for its efficacy in enhancing brain strength, preventing senile dementia, and preventing cerebral infarction, so it is widely used for related purposes. Specifically, it is known to have medicinal effects such as dementia prevention, air circulation, stroke, neuralgia, hypertension, diabetes, arteriosclerosis, liver cirrhosis, and fatty liver prevention because it has the effect of activating brain cells, enhancing memory, and promoting blood circulation.

Pogongyeong refers to the above-ground outpost of the dandelion ( Taraxacum platycarpum H. Dahlstedt ). It has been mainly used in dermatology and inflammatory diseases. Pogongyoung extract relieves atopic dermatitis by inhibiting inflammatory substances, acts as an antibacterial against Helicobacter pylori, and protects the gastrointestinal mucosa by removing active oxygen.

In recent years, a patent document showing that Pogongyoung extract has the effect of treating, improving, and preventing degenerative brain diseases accompanying memory cognitive impairment such as forgetfulness, dementia, Alzheimer's disease, Parkinson's disease, stroke, stroke, or Huntington's disease. No. 1380568 (announced on April 02, 2014) has been known.

Herbal medicine powder containing acupuncture, choseokjam and pogongyeong of the present invention is cheonggukjang fermented powder, deer antler fermented concentrated powder, cornus milk, angelica, dermis, gilkyung, schisandra chinensis, sukjihwang, red ginseng, galgeun, bokryeong, gojija, jingeung, red ginseng, ginger, Any one or more selected from the group consisting of cheonma may be further included. It may be ideal for realizing excellent efficacy that all the composition of the herbal medicine powder is included, but is not limited thereto.

Cheonggukjang fermented powder is powdered by fermenting cheonggukjang made by fermenting soybeans in a traditional way. Rich in nutrients, it helps anti-cancer, inflammation, immunity, constipation, diet and anti-aging.

In particular, Cheonggukjang fermented powder increases the amount of a neurotransmitter called acetylcholine, which is insufficient in dementia patients, and is helpful in preventing senile dementia.

Nattokinase is effective in reducing blood clots, relieving hypertension, and regulating blood sugar. In addition, strong proteolytic enzymes produced by fermenting bacteria facilitate digestion, and the content of vitamin B2 and calcium increases during the fermentation process, and a sticky, mucous substance mainly composed of polyglutamic acid is produced, which is calcium. Aids in absorption. When isoflavone, a physiologically active substance, is fermented, it changes into a structure that is easily absorbed, improving availability compared to unfermented soybeans, which helps to inhibit and prevent the progression of osteoporosis.

The antlers are cut before the horns of the stag of plum and marok are hardly keratinized. Deer antler contains minerals including collagen, ash, calcium, protein, fat, glycosaminoglycans, sialic acid, uronic acid, insulin-like growth factor, milk secretion hormone, luteinizing hormone. , Follicle-stimulating hormone and testosterone.

In addition, deer antler has long been used as an excellent tonic in oriental medicine, and has been frequently used in the treatment and prevention of weak constitutions. The pharmacological effects of deer antler include nervous breakdown, tonic effect, anemia, arthritis, sexual function improvement, anti-aging, immunity strengthening, hematopoietic effect, antithrombosis, lowering blood pressure, anti-fatigue, anti-stress, anti-inflammatory, cholesterol lowering, and increasing immune activity. have.

Cornus is the fruit of a deciduous tree, a deciduous tree belonging to the dogwood family, and contains various organic acids, iridoid glycosides such as loganin and sweroside, tannins, and vitamins. Has been. Cornus milk digests protein, diuresis, and protects the liver. In particular, it has been found that loganin relieves oxidative stress and has cognitive enhancement functions. It has the effect of improving diabetes and enhancing immunity.

Angelica refers to the root of Angelica Angelica, which is in the parsley family. Ingredients of Angelicae include organic acids, Phhalides, and polysaccharides. It has memory improvement, hematopoietic activity, immunomodulatory activity, antioxidant activity, liver protection, gastrointestinal protection activity, and antidiabetic activity.

The dermis is the fruit bark of the mature fruit of the tangerine tree, and contains compounds such as vitamins, limonoids and flavonoids.In particular, hesperidin, as a major component of flavonoids, Naringin and others. The dermis is a tendon placebo and has gastrointestinal smooth muscle relaxation, gastric juice secretion, anti-allergic effect, anti-gastric ulcer action, ear sputum, vascular permeability inhibition, and antioxidant activity.

Gilkyung is the root of bellflower and contains a large amount of saponin. Among them, a component called Platycodin D has anti-cancer activity, anti-inflammatory effect, anti-obesity effect, and cholesterol-lowering effect. In oriental medicine, plantain is used as a representative expectorant antitussive for respiratory diseases.

Schisandra chinensis is mainly used for medicinal purposes, and the representative component of the fruit composed of moisture, protein, and fat is schizandrin. Pharmacologically, it has dementia prevention effect, liver function improvement effect, anti-obesity effect, antitussive expectorant effect, and anti-stress effect. In particular, Gomisin A and schizandrin components of Schisandra chinensis are known to be helpful in the prevention and treatment of Alzheimer's disease.

Sukjihwang is the root of Rehmannia (九蒸九曝; steamed and dried nine times), catapol, lemanin, carotene, beta-sitosterol, 5- It contains hydroxymethylfurfural (5-Hydroxymethylfurfural), vitamin A, and sugars including glucose, raffinose and mannotriose as main components.

It is mainly used as a blood tonic, hemostatic and antipyretic agent, and is also used for anemia, pulmonary tuberculosis, weakness, and male infertility. It has anti-wrinkle effect, whitening effect, and blood pressure lowering effect.

Red ginseng refers to the process of steaming and drying fresh ginseng, the root of ginseng, without peeling the epidermis. Ginsenoside R0, Ginsenoside Ra1~3, Rb1~3, Rc, Rd, Rg3, Rh2, Rs1, Rs2, notoginsenoside R4 (notoginsenoside R4), ginseng saponin Re, Rf, Rg1~2, Rh3 and It contains major components of saponin, such as Rh4, and also contains saccharides, enzymes, and inorganic elements.

Ginseng is a representative adaptogen, and has central nervous excitation and anti-fatigue effects in relation to the nervous system. In addition, it has an effect of lowering blood pressure, anti-diabetes, and improving cholesterol metabolism in relation to the circulatory system, and has anti-ulcer, anti-inflammatory, and anti-tumor effects related to the immune system.

Brown root is the root of arrowroot and contains ingredients such as puerarin, daidzein, daidzin, and genistein.

Accordingly, it exhibits antioxidant, antifungal, anti-inflammatory, anti-cancer and hepatoprotective functions, and helps in the treatment of cardiovascular diseases such as hypertension. In particular, it is effective in improving brain function, and has the effect of reducing diabetes and cholesterol.

Bokryeong is a fungus parasitic to pine trees, and the texture is slightly thick and soft, and the taste is sweet and flat. Diuresis, suppression, sedation, intestinal relaxation, blood sugar lowering, immunity enhancing and anti-tumor effects.

Goji is the fruit of the goji tree or subzero goji. Carotenoids such as betaine, cerebroside, zeaxanthin, and physalien, various pyrrole derivatives, cyperone, vitamin B1, dihydroactinidine (dehydroactinidiolide), safranal, beta-ionone, megastigmatrienone, 3-hydroxy-beta-ionone, sco Scopoletin, N9-formylharman, 1-carbomethoxy-beta-carboline,

It contains components such as alkaloids such as perlolyrine and betaine.

Betaine, one of the choline metabolites, inhibits fatty liver, lowers the concentration of triglycerides in the blood, and regulates the osmotic pressure of hepatic kidney cells. In addition, goji japonica acts to inhibit liver damage by inhibiting antioxidant activity and CYP2E1 expression. In addition, it suppresses insulin resistance and improves diabetes, promotes immunity, anti-aging, anti-arteriosclerosis, female hormone-like action, anti-tumor action and hematopoietic function. In addition, as the fermentation takes place, goji can promote the growth of lactic acid bacteria.

Creation is the root of sapju, and the taste is spicy and bitter. It strengthens the stomach, prevents obesity, protects the kidneys, helps to excrete urine, and has the effect of eliminating fatigue and thirst, and eliminating poison and pain in the body.

Hongguk is red rice made by fermentation with yeast fungus. It has a koji scent similar to makgeolli, is mild and non-toxic, relieves indigestion and diarrhea, promotes blood circulation, and strengthens digestive function. It also lowers cholesterol.

Ginger has a spicy taste and fragrant odor, and promotes secretion of gastric juice, improves digestion, excites the heart, promotes blood circulation, and inhibits it.

Chunma is a perennial herb belonging to the Orchidaceae family, and is made of tubers like potatoes. It has properties that cannot be photosynthesized and does not have roots, so it grows by receiving nutrients from the parasitic basidiomycete, Armillaria Mellea.

Representative ingredients of Chunma include gastrodin and Parsinin C. Traditionally, it has been used as an antiepileptic drug, and in particular, it improves memory, prevents dementia, promotes blood circulation, has anticonvulsant action, lowers blood pressure, and has antioxidant properties.

It is preferable that the herbal medicine powder of the present invention specifically includes 3 to 9 parts by weight of acupuncture, 6 to 18 parts by weight of Choseokjam, and 2 to 6 parts by weight of Pogongyeong, based on 100 parts by weight of the medicinal material.

In addition, the herbal medicine powder is based on 100 parts by weight of the medicinal material, 2 to 6 parts by weight of cheonggukjang fermented powder, 5 to 15 parts by weight of antler fermented concentrated powder, 5 to 15 parts by weight of cornus oil, 5 to 15 parts by weight of Angelicae, 4 to 12 parts by weight of the dermis Parts by weight, Gilkyung 2 to 6 parts by weight, Schisandra chinensis 2 to 6 parts by weight, Sukjihwang 2 to 6 parts by weight, Red ginseng 2 to 6 parts by weight, Galgeun 2 to 6 parts by weight, Bokryeong 2 to 6 parts by weight, Gugija 2 to 6 parts by weight Any one selected from the group consisting of parts, creation 2 to 4 parts by weight, hongguk 2 to 4 parts by weight, 3 to 7 parts by weight of ginger, and 1 to 3 parts by weight of cheonma may be further included.

In the present invention, the compound fermented powder contained in order to improve fermentation efficiency is preferably fermented with at least one selected from the group consisting of yeast and Bacillus bacillus.

Preferably, the yeast is any one selected from the group consisting of Saccharomyces, sp. , Shizosaccharomyces, sp. , and Klureromyces sp. It can be more than that.

Specifically, the yeast is Saccharomyces cerevisiae (Saccharomycescerevisiae), Shijo caromyces pombe (Schizosaccharomycespombe ), Klureromyces lactis (Klureromyceslactis) and Saccharomyces boulardii (Saccharomyces boulardii). Any one or more selected from the group may be included.

The fermented relief acupuncture of the present invention contains new grains as food for the yeast and Bacillus bacillus.

New grain is a natural fermentation agent mainly used to make alcohol in the traditional way. It is fermented with yeast by floating grains such as wheat, rice or steamed beans. It is also called the so-called Shinguk or Nuruk.

New grains contain various yeast bacteria, and contain ingredients such as essential oils, glycosides, fatty oils, and vitamin B. In oriental medicine, it is mainly used as a digestive agent. It strengthens the digestive system and promotes digestion when ingested. It can also be used for sudden body, abdominal pain, jaundice, and stomach cramps.

New grains serve as food for yeast and Bacillus bacillus, helping the growth of bacteria and promoting the fermentation process. In addition, it facilitates the digestion and absorption of active ingredients of the fermented relief acupuncture stage disclosed by the present invention.

The combination of the complex fermented powder and the new grain can further improve the fermentation efficiency. When fermentation is activated, the nutrients of the fermented safe acupuncture are further strengthened, and the absorption of effective ingredients for dementia can be maximized, the bitter taste and peculiar aroma of the herbal medicine are reduced, and the burden on the stomach, liver, and intestines is relieved, making it easier for the intaker to take. do.

In the present invention, in addition to the complex fermented powder and new grains, purified water, fructooligosaccharide or organic unrefined sugar may be further added.

Fructoligosaccharides and organic unrefined sugars play a role in helping fermenting bacteria to actively work during the fermentation process. Specifically, they serve as food for beneficial bacteria and can promote the growth of bacteria. In addition, it facilitates the digestion and absorption of the fermented relief acupuncture stage disclosed by the present invention.

The number of microorganisms living in the human intestine is about 100 to 700 trillion, and the main food for these microorganisms is glucose. When ingesting oligosaccharides or unrefined sugar, it is not decomposed in the small intestine and is transferred to the large intestine, making it a good food for the beneficial colonies. Eventually, by maintaining or increasing the amount of beneficial bacteria in the intestine, it activates intestinal movement to facilitate digestion and absorption.

The present invention provides a method of manufacturing a fermented safe acupuncture dan.

Specifically, the first step of obtaining an extract concentrate using at least one or more medicinal materials selected from the group consisting of Seokchangpo, Baekbokshin, Wonji, and Hyunggae;

A second step of kneading and fermenting the herbal medicine powder, complex fermented powder and new grains containing acupuncture, choseokjam and pogongyeong in the extract concentrate;

A third step of drying and pulverizing the fermented dough to obtain a fermented medicinal powder; And

It includes a fourth step of blending the fermented medicinal powder and honey to make a ring.

In the present invention, in the method of manufacturing a fermented relief acupuncture, the first step is to obtain an extract concentrate using at least one or more medicinal materials selected from the group consisting of Seokchangpo, Baekbokshin, Wonji, and Hyeonggaesu. After separating the medicinal material and the tang liquid, the tang solution is concentrated to obtain an extract concentrate.

The medicinal material may include at least one or more selected from the group consisting of Seokchangpo, Baekbokshin, Wonji, and Hyunggaesu. According to an embodiment of the present invention, an extract concentrate is prepared using a medicinal material consisting of 20 to 40% by weight of seokchangpo, 20 to 40% by weight of baekbokshin, 20 to 40% by weight of the base paper, and 5 to 10% by weight of the number of molds.

By uniformly mixing Seokchangpo, Baekbokshin, Wonji, and Hyeonggaesu, which have different effective ingredients for dementia, it is possible to present a comprehensive treatment effect for the dementia group with various causes and lesions. In addition, it is possible to increase the efficacy in relieving and preventing early dementia through the above combination.

When the seokchangpo and the base paper are out of the range of 20 to 40% by weight, respectively, the memory improvement or dementia prevention effect may be lowered. If the amount of Baekbokshin is less than 20% by weight, the nerve stabilizing effect may decrease, and if it exceeds 40% by weight, excessive urine may come out. If the number of molds is out of the range of 5 to 10% by weight, the overall blending ratio may be broken, resulting in a decrease in memory improvement and dementia prevention effect.

In the first step, it is preferable to add purified water of 8 to 11 times the weight of the medicine when putting the medicine into the water heater. The amount of purified water should take into account both the degree to which the dried medicinal material absorbs water (absorption) and the amount by which water evaporates (evaporation) during the heating process.

If the amount of purified water added is less than 8 times the weight of the medicine, the active ingredient may not be completely leached, and the active ingredient may be destroyed during the evaporation of water. On the other hand, when the added purified water exceeds 10 times the weight of the medicine, the extraction rate of the active ingredient may increase, but after that, it takes a long time to concentrate and the content of the active ingredient is also lowered, resulting in a decrease in functionality.

In the first step, after putting the medicine and purified water in a water heater, it is preferable to hot water for 100 to 150 minutes at 80 to 100°C according to this embodiment.

This is because when proceeding to the heating temperature as described above, the diffusion rate may be improved and the extraction rate of the active ingredient may be increased.

If the hot water temperature is less than 80°C, the extraction efficiency is lowered, so that the active ingredient may be insufficient in the hot water, and there is a risk that the possibility of microbial growth is also increased. On the other hand, when the temperature exceeds 100°C, it may be effective in terms of sterilization, but the efficacy of the medicinal material may be degraded due to destruction of proteins or colloids, or elution of unnecessary components not related to the efficacy such as starch or fiber.

In addition, the hot water is performed within the time range of 100 to 150 minutes. This is desirable in terms of time, economy and efficacy. The above range is ideal when considering not only the extraction rate of the active ingredient but also the flavor, color, taste, and brix of the extract.

In this case, when the heating time is less than 100 minutes, the extraction rate may decrease. If it exceeds 150 minutes, the active ingredients of the medicinal herb cannot be completely extracted. In particular, since essential oil components or specific compounds have the property of being destroyed by extraction for a long time, maintaining an appropriate heating time is an important factor that can increase the active ingredients of medicinal materials.

After boiling the medicinal material, separate the medicinal material from the bath liquid. At this time, it is preferable to concentrate the bath liquid to 2 to 3 times the total amount of the medicine. For example, on the basis of 1 kg of medicinal herbs, the bath liquid obtained by defrosting medicinal herbs is concentrated into an extract of 2000 to 3000 cc.

The second step refers to a step of mixing and fermenting the extract obtained in the first step by kneading the herbal medicine powder, complex fermented powder and new grains containing acupuncture, choseokjam and pogongyeong.

Here, the herbal medicinal powder containing acupuncture, choseokjam and pogongyeong is cheonggukjang fermented powder, antler fermented concentrated powder, cornus milk, angelica, dermis, gilgyeong, schisandra chinensis, sukjihwang, red ginseng, galgeun, bokryeong, gugija, creation, hongguk, ginger, cheonmaro. Any one or more selected from the group consisting of may be further mixed. It may be ideal for realizing excellent efficacy that all the composition of the herbal medicine powder is included, but is not limited thereto.

Specifically, it is preferable that the herbal medicine powder contains 3 to 9 parts by weight of acupuncture, 6 to 18 parts by weight of Choseokjam, and 2 to 6 parts by weight of Pogongyeong, based on 100 parts by weight of the medicinal material according to this embodiment.

In addition, the herbal medicine powder is based on 100 parts by weight of the medicinal material, 2 to 6 parts by weight of cheonggukjang fermented powder, 5 to 15 parts by weight of antler fermented concentrated powder, 5 to 15 parts by weight of cornus oil, 5 to 15 parts by weight of Angelicae, 4 to 12 parts by weight of the dermis Parts by weight, Gilkyung 2 to 6 parts by weight, Schisandra chinensis 2 to 6 parts by weight, Sukjihwang 2 to 6 parts by weight, Red ginseng 2 to 6 parts by weight, Galgeun 2 to 6 parts by weight, Bokryeong 2 to 6 parts by weight, Gugija 2 to 6 parts by weight Any one selected from the group consisting of parts, creation 2 to 4 parts by weight, hongguk 2 to 4 parts by weight, 3 to 7 parts by weight of ginger, and 1 to 3 parts by weight of cheonma may be further included.

The complex fermented powder of the present invention is characterized in that at least one selected from the group consisting of yeast and Bacillus bacillus.

Preferably, the yeast is any one selected from the group consisting of Saccharomyces, sp. , Shizosaccharomyces, sp. , and Klureromyces sp. It is characterized by the above.

Specifically, the yeast is Saccharomyces cerevisiae (Saccharomyces cerevisiae), Shijo caromyces pombe (Schizosaccharomycespombe ), Klureromyces lactis (Klureromyceslactis), Saccharomyces boulardii (Saccharomyces boulardii). Includes any one or more selected from the group.

By fermenting using the composite fermented powder configured as described above, fermentation efficiency can be further improved.

According to this embodiment, with respect to 100 parts by weight of the extract concentrate, the complex fermented powder is preferably mixed in an amount of 1 to 3 parts by weight. More preferably, it is mixed with 2 parts by weight of the complex fermented powder relative to 100 parts by weight of the extract concentrate.

In this case, when the amount of the complex fermented powder is less than 1 part by weight, the number of fermenting bacteria may be insufficient, and an increase in the content of active ingredients by fermentation may also be insignificant. If it exceeds 3 parts by weight, the fermentation bacteria may proliferate excessively, or the content of the active ingredient may not reach the target value, resulting in a decrease in efficacy.

The fermented relief acupuncture of the present invention contains new grains as food for the yeast and Bacillus bacillus.

The new grain helps the growth of bacteria to further activate the fermentation process, and facilitates the digestion and absorption of active ingredients by the fermentation safe acupuncture stage disclosed by the present invention. According to this embodiment, it is preferable to mix 10 to 30 parts by weight of new grains based on 100 parts by weight of the extract concentrate.

In the present invention, in order to improve fermentation efficiency, in addition to the complex fermented powder and new grains, purified water, fructooligosaccharide or organic unrefined sugar may be further added.

When fermentation is activated, the nutrients of the fermented safe acupuncture are further strengthened, and the absorption of effective ingredients for dementia can be maximized, the bitter taste and peculiar aroma of the herbal medicine are reduced, and the burden on the stomach, liver, and intestines is relieved, making it easier for the intaker to take. do.

In the second step, mixed fermentation is performed by combining the liquid extract and the solid herbal medicine powder, complex fermentation powder, and new grains.

Herbal medicine has been limited in its use due to its bitter taste and peculiar aroma compared to its functionality. In addition, there is a problem in that it is difficult to change the formulation such as beverages and extracts.

As part of a method for overcoming this, the present invention is to perform mixed fermentation for maximizing the efficacy and effect of the herbal medicine, and for ease of administration.

Specifically, the mixed fermentation is preferably performed at 30 to 50° C. for 48 to 96 hours according to this embodiment. More preferably, fermentation is performed at 37 to 43°C, and most preferably at 40°C for 72 hours.

Specifically, the temperature condition of 30 to 50°C is an appropriate range in which solid fermentation can be performed. Solid fermentation may provide convenience of a process since fermentation can be performed at a temperature that is easy to handle.

In this case, when the fermentation temperature and time are less than the above range, the fermentation strain may be insufficient, and when it is exceeded, the fermentation strain may be insufficient or death. Through the fermentation conditions of 48 to 96 hours at 30 to 50° C., the bitter taste and peculiar aroma of the herbal medicine can be reduced, and the active ingredient and its absorption rate can be increased.

The second step may further add a sterilization step before the mixed fermentation. The sterilization may be performed at 115 to 121°C for 10 to 20 minutes, and preferably at 121°C for 15 minutes.

The third step is to dry and crush the fermented dough to obtain fermented medicinal powder. In order to reduce the moisture content of the fermented dough to produce a powder, it is dried for 8 to 12 hours at 50 to 60°C according to this embodiment. Preferably, it can be carried out at 60° C. for 10 hours.

Here, when the drying temperature and time are less than 8 hours and 50° C., the drying may not be sufficient and thus the powdering operation may be difficult. In addition, if it exceeds 12 hours and 60 ℃, the fermentation strain may be killed and the loss of active ingredients may occur.

The dried product preferably has a moisture content of 8% or less, and more preferably 5% or less. The smaller the moisture content, the better the powdering is, and it is suitable for use in the fourth step.

In the third step, the dried product may be pulverized to obtain a fermented medicinal powder. According to this embodiment, the fermented medicinal powder is characterized in that obtained by pulverizing the dried product into 180 to 220 particles.

The third step may further include filtering the obtained fermented medicinal powder using a sieve having a size of 180 or more. The selected fermented medicinal powder facilitates dough manufacturing in the fourth step and improves moldability.

The fourth step is to combine the fermented medicinal powder obtained in the third step and honey to make a pill. The fourth step is characterized in that it consists of a kneading step and a molding step.

The kneading step is a step of kneading by mixing honey with the fermented medicinal powder obtained in the third step.

It is preferable to mix and knead 60 to 90% by weight of fermented medicinal powder and 10 to 40% by weight of honey according to this embodiment.

By mixing honey with fermented medicinal powder, it is possible to make dough, improve moldability, and reduce the bitter taste and peculiar aroma of medicinal materials.

Compared to its functionality, herbal medicine has a limit on its use due to its bitter taste and unique aroma. In particular, in the case of infant products, there has been a problem of low dosage preference. In the processing of herbal medicines, there is a difficulty in changing the formulation of beverages and extracts.

Accordingly, in the present invention, by blending honey with the fermented medicinal powder, sweetness is given to the pill and the unique taste and bitter aroma of the medicinal material are reduced, thereby improving the intake of the pill. Furthermore, it is possible to impart an appropriate viscosity so that it can be molded and maintained in a ring shape.

If the amount of honey to be blended is less than 10%, the pill may become hard and ingestion may become uncomfortable.If the amount of honey to be blended is more than 40%, the dough may stick to the machine during the pulping operation or stick to the wrapping paper during packaging work. .

The molding step is to shape the dough obtained in the kneading step into a ring shape. The size of the ring may be 15 to 20 mm, and the weight may be 3 to 5 g. Preferably, to prepare a ring with 18mm, 4g. The molding step may include both the process of forming the shape of the ring and the process of coating.

Wrap the finally prepared pill.

Hereinafter, the present invention will be described in more detail through examples.

The present examples are for explaining the present invention in more detail, and the scope of the present invention is not limited to these examples.

<Example 1>

After boiling 30.8% by weight of Seokchangpo, 30.8% by weight of Baekbokshin, 30.8% by weight of raw paper, and 7.6% by weight of the number of molds, the medicinal material and the bath were separated, and the bath was concentrated to prepare an extract concentrate.

With respect to 9.1 parts by weight of the extract concentrate, 4.3 parts by weight of acupuncture, 8.7 parts by weight of Choseokjam, 2.9 parts by weight of Pogongyeong, 2.9 parts by weight of cheonggukjang fermented powder, 7.2 parts by weight of fermented deer antler powder, 7.2 parts by weight of cornus oil, 7.2 parts by weight of angelica angelica, Dermis 5.8 parts by weight, Gilgyeong 2.9 parts by weight, Schisandra chinensis 2.9 parts by weight, Sukjihwang 2.9 parts by weight, Red ginseng 2.9 parts by weight, Galgeun 2.9 parts by weight, Bokryeong 2.9 parts by weight, Gugija 2.9 parts by weight, Jinseong 2.2 parts by weight, Hongguk 2.2 parts by weight, Ginger 3.6 parts by weight, herbal medicine powder including 0.7 parts by weight of cheonma, 1.4 parts by weight of complex fermented powder, and 14.4 parts by weight of new grain were mixed.

After the mixing, the solid was fermented at 40° C. for 72 hours, dried at 60° C. for 10 hours so that the moisture content was 5% or less, and then pulverized to a particle size of 180 to 220 to prepare a fermented medicinal powder.

The fermented medicinal powder 80% by weight and 20% by weight of honey were mixed and kneaded, and then formed into a ring shape of 15 to 18 mm and 4 to 5 g to prepare a fermented relief acupuncture.

<Comparative Example 1>

After boiling 30.8% by weight of Seokchangpo, 30.8% by weight of Baekbokshin, 30.8% by weight of raw paper, and 7.6% by weight of the number of molds, the medicinal material and the bath were separated, and the bath was concentrated to prepare an extract concentrate.

82.9% by weight of the fermented medicinal powder, 5% by weight of the extract concentrate, and 12.1% by weight of honey were mixed, kneaded, molded into a ring, and dried after sugar to prepare a ring.

<Comparative Example 2>

After boiling 30.8% by weight of Seokchangpo, 30.8% by weight of Baekbokshin, 30.8% by weight of raw paper, and 7.6% by weight of the number of molds, the medicine and the bathing liquid were separated.

The separated medicinal material was fermented with fermented water, dried and pulverized to prepare a fermented medicinal powder. The fermented medicinal powder 88.1 wt%, mixed powder paste 6.9 wt%, and honey 5 wt% were mixed, kneaded, molded into a ring shape, and dried after sugar to prepare a fermented pill.

<Experimental Example 1> Sensory evaluation

Sensory evaluation was performed for Example 1 and Comparative Examples 1 and 2.

Among trained professional sensory test personnel (50 people [25 men, 25 women] with experience in sensory testing for more than 2 years), 30 people with relatively excellent taste were selected and analyzed for quantitative description of taste, aroma, texture, and preference. (Quantitative Descriptive Analysis: QDA) was performed. The sensory test was performed with a 5-point measurement method (1: very bad, 2: bad, 3: moderate, 4: good, 5: very good), and preference was investigated and the rank was calculated as an average.

In Example 1 and Comparative Examples 1 and 2, one was taken and evaluated, and then the mouth was rinsed with water, and the other was taken and evaluated.

The results are shown in Table 1 below.

As can be seen from Table 1, it was confirmed that Example 1 was superior to Comparative Examples 1 and 2 in all items as a whole.

<Experimental Example 2> Clinical trial evaluation

The fermented relief acupuncture dan prepared in Example 1 was evaluated for efficacy against dementia in elderly patients.

As an index of dementia symptoms, the level of harmful free radicals having the same type of toxicity as oxygen was measured. Harmful free radicals are known as one of the main causes of aging, and the higher the level of harmful activated carbon in the human body, the higher the probability of occurrence of dementia, various cancers, vascular diseases, hepatitis, gastritis, arthritis and autoimmune diseases. At this time, if the level of harmful active oxygen was less than 500, it was judged as "normal".

In order to conduct a clinical experiment on dementia symptoms, after taking the fermented relief acupuncture group prepared in Example 1 for elderly patients visiting the hospital, scores according to the Korean Simple Mental State Test (K-MMSE) method The degree of improvement was evaluated by measuring. At this time, the K-MMSE test result was based on a total of 30 points, and 14 points or less were classified as severe dementia, 15 to 19 points were mild dementia, 20 to 23 points were suspected of dementia, and 24 points or more were classified as normal.

The results are shown in Table 2 below.

In the above 7 patients (2 severe dementia, 5 mild dementia), fermented relief acupuncture group was taken once a day for 2 months, and K-MMSE test was conducted once a month. It was confirmed that the score increased by 4 points.

In addition, the number of patients converted from mild dementia patients (15 points to 19 points) to suspected patients was 3 out of 5, and the remaining 2 were also 18 points and 19 points, respectively, which was close to the standard score of 20 points.

From the above results, the fermented relief acupuncture dan prepared in Example 1 was confirmed to have excellent efficacy against dementia according to the Korean simplified mental state test (K-MMSE) method.

The embodiments of the present invention have been described above with reference to the accompanying drawings, but those of ordinary skill in the art to which the present invention pertains can be implemented in other specific forms without changing the technical spirit or essential features of the present invention. You will be able to understand. Therefore, the embodiments described above are illustrative in all respects and are not limited thereto.

Claims (15)

In the extract concentrate obtained using at least one or more medicinal materials selected from the group consisting of Seokchangpo, Baekbokshin, Wonji, and Hyeonggaesu,
Acupuncture, Choseokjam, Pogongyeong, Cheonggukjang fermented powder, Deer antler fermented concentrated powder, Cornus milk, Angelicae, dermis, Gilgyeong, Schisandra chinensis, Sukjihwang, Red ginseng, Galgeun, Bokryeong, Gugija, Jeung, Hongguk, Ginger and Cheonma,
A fermented relief acupuncture for the alleviation or prevention of early dementia that is reconstituted after fermentation by mixing at least one selected from the group consisting of yeast and Bacillus bacillus. The method of claim 1, wherein the extract concentrate is extracted from 20 to 40% by weight of Seokchangpo, 20 to 40% by weight of Baekbokshin, 20 to 40% by weight of the base paper, and 5 to 10% by weight of the number of molds. Fermented Safe Acupuncture Group. delete delete The method of claim 1, wherein the yeast is selected from the group consisting of Saccharomyces, sp. , Shizosaccharomyces, sp ., and Klureromyces sp. Fermented relief acupuncture for alleviation or prevention of early dementia, characterized in that one or more. A first step of obtaining an extract concentrate using at least one or more medicinal materials selected from the group consisting of Seokchangpo, Baekbokshin, Wonji, and Hyunggae;
In the extract concentrate, acupuncture, choseokjam, pogongyeong, cheonggukjang fermented powder, antler fermented concentrated powder, cornus milk, angelica, dermis, gilkyung, schisandra chinensis, sukjihwang, red ginseng, galgeun, bokryeong, gugija, seonghwa, red ginseng, ginger and cheonma are contained. A second step of kneading and fermenting at least one selected from the group consisting of herbal medicine powder, yeast and Bacillus bacillus and kneading new grains;
A third step of drying and pulverizing the fermented dough to obtain a fermented medicinal powder; And
A method of manufacturing a fermented relief acupuncture step comprising a fourth step of blending the fermented medicinal powder and honey to make a pill. The method of claim 6, wherein the extract concentrate is extracted from 20 to 40% by weight of Seokchangpo, 20 to 40% by weight of Baekbokshin, 20 to 40% by weight of raw paper, and 5 to 10% by weight of the number of molds. Way. delete delete The method of claim 6, wherein the yeast is selected from the group consisting of Saccharomyces, sp ., Shizosaccharomyces, sp. , and Klureromyces sp. A method of manufacturing a fermented safe acupuncture dan, characterized in that at least one. The method of claim 6, wherein the complex fermented powder is mixed in an amount of 1 to 3 parts by weight based on 100 parts by weight of the extract concentrate. The method of claim 6, wherein the new grains are mixed in an amount of 10 to 30 parts by weight based on 100 parts by weight of the extract concentrate. The method of claim 6, wherein the mixed fermentation is performed at 30 to 50°C for 48 to 96 hours. The method of claim 6, wherein the fermented medicinal powder is pulverized to a particle size of 180 to 220. The method of claim 6, wherein the pill is blended with 60 to 90% by weight of fermented medicinal powder and 10 to 40% by weight of honey.