KR101974886B1 - Gongjindan for memory enhancement and learning capabilities and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a resonance stage for improving memory and learning ability and a method of manufacturing the same. More particularly, the present invention relates to an inner layer comprising a musk powder, an antler powder, a corn oil powder, a Angelica keiskei powder and a ginseng powder, Wherein the inner layer and the outer layer each comprise an adhesive material, and the adhesive material of the inner layer is a liquid omega-3 material, and the inner layer and the outer layer each include an adhesive material, And the adhesive material of the outer layer comprises any one of honey, oligosaccharide and millet. The resonance end according to the present invention is advantageous in that it is safer without side effects, has anti-fatigue activity and improves learning ability by helping brain activity, especially memory enhancement.

Description

[0001] Gongjindan for memory enhancement and learning capabilities and manufacturing method [

The present invention relates to a resonance stage for improving memory capacity and learning ability, and more particularly, to a resonance stage for improving learning ability by having excellent activity for brain activity, particularly memory enhancement, and a manufacturing method thereof.

In Donguibogam, the resonance group said, "Even if the constitution is inherently fragile, this medicine will harden Tianjin 一日 (天元 一氣), causing water to rise and causing anger, so no white disease will occur." , Which is interpreted as having a meaning of preventive treatment for a patient's disease that is inherently weak and is frequently infected with disease. In other words, the resonance stage prevents aging, prevents disease, causes weakness in surgery or a big disease, weakness in mental and physical exertion, chronic fatigue is severe and recovery is slow, It is known to be useful in cases where the blood circulation is weak, the body is heavy, the nerves are sensitive, dizziness and insomnia are present, excessive stress and alcohol have weakened the liver function.

Therefore, the resonance stage helps to improve the physical and mental health by helping the circulation of blood clogged by the stress, which is called the origin of the panic disease, .

In addition, recently, with the polluted atmospheric conditions such as fine dust and dust, there is an increasing tendency of allergic diseases due to the immune system abnormality due to the eating habit of busy modern man's instant, Rhinitis, atopic dermatitis, chronic asthma, and symptoms of immunosuppression. With regard to the diseases that can be caused by weakening of the immune system, the resonance group can be helpful in that it is important to see the immune system and strengthen the immune system.

On the other hand, as the social environment is diversified, people are exposed to more stimuli and prompt brain activities to accommodate these stimuli. In particular, with the recent economic growth, environmental destruction caused by industrialization and industrialization, water pollution, and flooding of instant foods are threatening our health condition, and excessive consumption of nutrition due to meat diet centered on meat- And the absolute lack of exercise due to the development of civilization not only promotes obesity but also causes chronic degenerative diseases such as atherosclerosis, hypertension, coronary heart disease, myocardial infarction, angina pectoris, and stroke due to these obesity. In addition, adolescents, especially examinees, have long-term learning activities that not only cause their brains, mental and physical fatigue, but are also seriously affected by the healthy development of their brains.

Therefore, it is urgently required to develop a method of clearing the tired brain by improving the memory and promoting the recovery of fatigue as the society becomes complicated and the entrance competition becomes intense. In the recent growing period, .

In order to stimulate the brain and stimulate the brain, synthetic compounds have been used to improve the learning ability and memory. However, various kinds of side effects In recent years, development of products using natural products has been attempted.

A description of a product-related technology developed using natural products is disclosed in Korean Patent No. 10-524385, which discloses a composition for improving memory performance and improving learning ability of young children, which contains a herbal extract of Yongtan, And Korean Patent No. 10-530211 discloses a method for producing a Chinese cabbage such as a Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, , And Korean Patent No. 10-484416 discloses a health functional food composition which improves learning and memory-enhancing herbal composition containing Lycii fructus extract as an active ingredient. Is disclosed.

However, there were no cases of using memory resonance to improve memory and learning ability.

KR 10-524385 B1 KR 10-484416 B1

As described above, the present invention has been proposed in order to solve the problems of the prior art. The object of the present invention is to provide a safe, non-invasive, anti-fatigue activity and brain activity, And a method for producing the same.

In order to attain the above object, the resonance end for improving memory and learning ability of the present invention includes an inner layer including musk powders, antlerstock powder, corn oil powder, Angelica keiskei powder, and ginseng powder, a white bodied powder formed on the outer surface of the inner layer, Wherein the inner layer and the outer layer each comprise an adhesive material, wherein the adhesive material of the inner layer comprises omega-3 in the liquid phase, and the outer layer comprises at least one of an outer layer , And the adhesive material of the outer layer comprises any one of honey, oligosaccharide and millet.

Wherein the inner layer further comprises a ginseng powder, a groundnut powder, and a flower larva.

The method for manufacturing a resonance end for improving memory and learning ability according to the present invention comprises the steps of: (a) applying a liquid omega-3-containing adhesive to an inner layer powder comprising musk powders, antlerstock powder, corn oil powder, Angelica keiskei powder, (B) a step of mixing and kneading the materials, and (b) any one of honey, oligosaccharides and syrups is contained in the outer layer powder including at least one of Baebongrise powder, ground rice powder, Seokjangpo powder, Gejiae powder, (C) forming the dough of step (a) into a ring-shaped inner layer; and (d) mixing the outer layer of the inner layer of step (c) And forming an outer layer with the dough of the dough.

Wherein the inner layer powder of step (a) further comprises a ginseng powder, a groundnut powder and a flower larval powder, and after step (c), the outer layer of the inner layer of step (c) (D) a step of inoculating the outer layer of step (d) with a Lactobacillus strain; and (c) inoculating the Lactobacillus strain to the inner layer to which the adhesive substance has been applied. A step of fermenting the molded product inoculated with the lactobacillus fungus at 20 to 40 ° C for 5 to 30 days and applying an adhesive material containing any one of honey, oligosaccharide and lactose to the surface of the fermented molded product And further comprising:

The resonance end according to the present invention is advantageous in that it is safer without side effects, has anti-fatigue activity and improves learning ability by helping brain activity, especially memory enhancement.

Hereinafter, the present invention will be described in detail.

The resonance end according to the present invention is characterized in that the resonance end includes an inner layer including musk powders, antlerstock powder, corn oil powder, Angelica keiskei powder, and ginseng powder, and an outer layer formed on the outer surface of the inner layer, such as white bamboo powder, ground powder, Wherein the inner layer and the outer layer each comprise an adhesive material, the adhesive material of the inner layer comprises a liquid omega-3, and the adhesive material of the outer layer comprises honey, oligosaccharide and starch syrup And has an anti-fatigue and memory-enhancing action effect through the resonance end.

First, each material used as the inner layer and the outer layer will be described.

The musk powders are musk powders, which are secretions obtained by drying the musk glands of musk deer, which is a medicinal substance which cleanses the stomach and mind, and is mainly used as a cardiotonic and a stimulant.

The above-mentioned antler powder refers to a crushing of a male horn which is slightly soft and soft and covered with hair evenly if it is not yet keratinized within 2 months of its beginning of growth. The antler contains not only therapeutic effects such as a tonic action, a blood-related action, a strong exercise action, an analgesic action, a hematopoietic action, a growth-promoting action, a treatment for heart failure and a functional hyperactivity, as well as a fatigue recovery, Effects and so on.

The powder of corn oil is obtained by pulverizing dried pulp of Cornus officinalis which is a bough of Cornaceae and is cornin, Morroniside, Loganin, tannin , Saponin, etc., and organic acids such as wine, malic acid, tartaric acid and the like, and also contains vitamin A and a large amount of saccharides. The seeds contain palmitic acid, oleic acid, linoleic acid, etc., and the cornin ingredient has the excitatory action of the parasympathetic nerve.

The Angelica sinensis D. powder of Angelica sinensis D., which is a perennial plant of Umbelliferae, is a mixture of Bergaptene, butylidenephthalide and fatty oils, vitamins, It contains analgesics, analgesics, drainage, hemostasis, and tonic action.

The above-mentioned ginseng powder refers to a powder dried at the highest grade of red ginseng, and contains a large amount of active ingredient such as saponin, which is useful for enhancing physical strength.

The above-mentioned Baekbongryong powder is obtained by pulverizing sclerotia of Poria cocas wolf. It has been used as a tonic for a long time, and has been used as a medicament for treating a fragile person or a chronic gastrointestinal patient after suffering from a disease.

The ground powder is dried and pulverized roots of raw paper, and is used as an expectorant, a tonic agent, and a proprietary agent.

The above-mentioned Seokchangpo powder is made by pulverizing the roots of Seokchangpo, cleanses the mind, promotes blood circulation, and eliminates customs and phlegm.

The above-mentioned ginger powder is pulverized by pulverizing the fruit of the ginger tree, and has non-specific immune enhancing action, hematopoietic action, cholesterol lowering action, anti-hepatic action, blood pressure lowering, blood glucose lowering, growth promotion and anti-cancer action.

The saccharide powder is obtained by pulverizing the seeds of the seeds, and it treats the symptoms of liver flushing, congestion of the eyes, swelling, sickness and tears.

The hwanggi powder is dried and crushed by the roots of the hwanggi period, and has a tendon action, an immune function regulating action, and an anti-inflammatory action.

The resonance end of the present invention using the above-described materials is composed of an inner layer and an outer layer. The material or basic essential material having strong fragrance and poor taste and unpleasant feeling upon ingestion is composed of an inner layer, This improves learning ability by allowing young people to easily ingest, restoring fatigue, improving physical fitness, and increasing brain activity. In addition, since the base material is composed of the inner layer, even if the constitution and the state of the consuming person are different, only the outer layer is formed differently so that it can be easily manufactured.

That is, the present invention basically comprises an inner layer of musk powders, antler grains, corn oil powders, Angelica keiskei powder, and Angelica griseus powder as inner layers so as to have anti-fatigue effect and have excellent activity in brain activity. The outer layer is composed of at least one of a white bream powder, a ground powder, a seaweed powder, a ginger powder, a lucifer powder, and a yellow powder, and the powder constituting the outer layer is determined according to the constitution, health condition and the like of the recipient. In the present invention, it is preferable to use all of the above-mentioned materials as powders. The size of the powder is not limited, but it is sufficient if it is about 50 to 200 mesh.

In addition, the inner layer and the outer layer each include an adhesive material, and the adhesive material of the inner layer includes omega-3 in a liquid state, and the adhesive material of the outer layer includes any one of honey, oligosaccharide, and syrup. Further, the adhesive material may further include water. The omega-3 has a strong taste and can not be easily ingested. The omega-3 is used only in the inner layer to block the malodorous taste. Honey, oligosaccharide and starch syrup, which are used as adhesive materials for the outer layer, .

Herein, the omega-3 is a kind of unsaturated fat containing carbon-carbon double bonds, and representative examples thereof include DHA (Docosahexaenoicacid) or EPA (Eicosapentaenoic acid), which is contained in fish oil and known to have an effect of improving hair . These omega-3s are found in animal and vegetable foods, which are rich in fish oil, plankton, seafood, soybean oil, and breast milk. They help normal brain growth and brain function development and lower heart disease risk. Therefore, in the present invention, omega-3 is used as an inner layer adhesive material, thereby blocking brain tastes and assisting brain activity. In the present invention, omega-3 is a liquid omega-3 which can be used irrespective of vegetable, animal, and specific species.

In the present invention, the inner layer and the outer layer may be composed of 1: 0.01 to 0.5 weight ratio, and the inner layer may contain 50 to 100 parts by weight of antler grains, 50 to 100 parts by weight of corn oil powder, 50 to 100 parts by weight of powder, 50 to 100 parts by weight of ginseng powder, and 50 to 500 parts by weight of adhesive material.

In addition, the outer layer includes 10 to 50 parts by weight of an adhesive material based on 100 parts by weight of at least one of white bamboo powder, ground powder, jasmine powder, ginger powder, lucifer powder and hwanggi powder.

The inner layer may further contain 50 to 100 parts by weight of the ginseng powder, 50 to 100 parts by weight of the groundnut powder, and 50 to 100 parts by weight of the flower powder. The ginseng powder, the groundnut powder and the flower larva powder It replenishes insufficient nutrients and fibrin, improves physical fitness, and increases brain activity.

Herein, the ginseng powder is obtained by drying the roots of the ginseng root and pulverizing the ginseng root, which is effective for the digestion failure, neuralgia, hepatitis and the like.

The soybean powder is obtained by drying and crushing the head portion of the seaweed, and the dietary fiber is abundant to prevent constipation.

The above-mentioned flower larvae are harvested for 1 to 2 days, washed, boiled in boiling water at 80 to 100 ° C for 1 to 10 minutes, microwaved at 700 to 800 W, It is dried for a minute and then pulverized. It is rich in vitamins and is also good for detoxification.

The ginseng powder, the groundnut powder and the flower larva powder are also not limited in their particle size, but it is sufficient that the powder is about 50 to 200 mesh.

The resonance end configured as described above can be taken 1 to 3 times a day, and the amount of the once-consumed dose may be 5 to 10 g or so.

On the other hand, the above resonance end can be taken as it is without fermentation, or it can be fermented and taken in a state in which an inner layer and an outer layer are formed.

Hereinafter, the production method thereof will be described in detail.

The method of manufacturing a resonance end according to the present invention comprises the steps of: (a) mixing an adhesive material containing omega-3 in liquid phase with an inner layer powder containing musk powders, antler seeds powder, corn oil powder, Angelica keiskei powder, And (b) an adhesive material containing any one of honey, oligosaccharide and syrup to an outer layer powder containing at least one of Baebongryeong powder, ground powder, Seokpan powder, Gejiae powder, (D) forming an outer layer of the dough of step (b) on the outer surface of the inner layer of step (c); and The method comprising the steps of:

(a) adding a liquid omega-3 fatty acid salt to an inner layer powder containing musk powders, antler grains, corn oil powders, 3  Mixing and kneading the adhesive material.

First, a powder for inner layer is prepared. As described above, the inner layer powder may further include a musk powder, an antler powder, a corn oil powder, a Angelica keiskei powder, and a ginseng powder, and may further comprise a ginseng powder, an immature powder, and a flower larva. At this time, the particle size of the inner layer powder is not limited, and it is enough if it is about 50 mesh to 200 mesh.

And an adhesive material containing omega-3 in a liquid phase is mixed with the inner layer powder. In this case, the adhesive material may further comprise water. The liquid omega-3 and water may be mixed at a weight ratio of 1: 0.1 ~ 0.5.

The mixing ratio of the batter is 50-100 parts by weight of antler grass powder, 50-100 parts by weight of corn oil powder, 50-100 parts by weight of Angelica powder, 50-100 parts by weight of ginseng powder, 50 to 100 parts by weight of the groundnut powder, 50 to 100 parts by weight of the flower fly larva powder and 50 to 500 parts by weight of the adhesive material.

(b) Baebongryeong powder, ground powder, Seokchangpo  Mixing and kneading an adhesive material comprising any one of honey, oligosaccharide, and millet in an outer layer powder comprising at least one of powder, ginger powder,

Next, an outer layer powder containing at least one powder selected from the group consisting of Baebongrise Powder, Ground Powder, Seokgupo Powder, Gugija Powder, Cucumber Powder, and Hwanggi Powder is prepared. At this time, the particle size of the powder for outer layer is not limited, and it is enough if it is about 50 mesh to 200 mesh.

Then, an adhesive material containing any one of honey, oligosaccharide and millet is mixed with the outer layer powder. At this time, the adhesive material may further include water. Any one of the honey, the oligosaccharide, and the syrup can be mixed with water at a weight ratio of 1: 0.1-0.5.

The mixing ratio of the dough is preferably in the range of 10 to 50 parts by weight based on 100 parts by weight of the outer layer powder.

(c) molding the dough of step (a) into a ring-shaped inner layer.

Next, the kneading in the step (a), that is, the inner layer kneading, is formed into a ring shape to produce an inner layer. At this time, the molding method is not limited and the size is not limited.

(d) forming an outer layer by dough of the step (b) on the outer surface of the inner layer of the step (c).

Next, an outer layer is formed on the outer surface of the molded inner layer. At this time, the method of forming the outer layer is not limited, and the outer surface of the inner layer may be coated or sprayed with a brush or the like.

At this time, the inner layer and the outer layer should be in a weight ratio of 1: 0.01 to 0.5.

Then, it can be naturally dried to complete the manufacture of the resonance stage.

After the step (c), the adhesive material containing any one of honey, oligosaccharide, and millet may be applied to the outer surface of the inner layer of step (c) (D) inoculating the outer layer of step (d) with a Lactobacillus strain; and (c) inoculating the Lactobacillus strain with the outer layer of step (d) A step of fermenting the molded product at 20 to 40 ° C for 5 to 30 days, and a step of applying an adhesive material containing any one of honey, oligosaccharide and millet to the surface of the fermented molded product.

That is, after step (c), an adhesive material including any one of honey, oligosaccharide, and millet is applied to the outer surface of the inner layer in step (c). At this time, the amount of application and the application method are not limited. For the smooth fermentation, Lactobacillus strains such as Lactobacillus brevis, Lactobacillus casei and Lactobacillus delbrueckii subsp. Strains are added to the inner layer coated with the adhesive material. Bactaricus, Lactobacillus fermentum, Lactobacillus helveticus, and Lactobacillus plantarum are inoculated. At this time, the amount of inoculation is not limited, but the inoculum can be inoculated at a concentration of 10 ⁵ to 10 ⁸ cfu / g to the inner layer.

After step (d), the outer layer of step (d) is inoculated with the lactobacillus strain, and the molded product inoculated with the lactobacillus fungus is fermented at 20 to 40 ° C for 5 to 30 days. The amount of the inoculum of the strain on the outer layer is also not limited. The outer layer may be inoculated at a concentration of 10 ⁵ to 10 ⁸ cfu / g.

Finally, in order to increase the degree of preference, an adhesive material containing any one of honey, oligosaccharide and millet is applied to the surface of the fermented molding. At this time, the application amount of the adhesive material is not limited.

Hereinafter, the present invention will be described in more detail with reference to specific examples.

(Example 1)

10 g of the musk powder, 10 g of the antler powder, 10 g of the fermented milk powder, 10 g of the Angelica powder, and 10 g of the ginseng powder were prepared and mixed. Then, 20 g of omega-3 in the liquid phase was mixed with the mixed powder to complete the inner layer kneading. Next, 15 g of honey was mixed with 50 g of white bream powder to complete the outer layer kneading.

The inner layer paste was formed into a ring. At that time, the weight of the ring was 4 g. Next, 1 g of the outer layer paste was applied to the outer surface of the ring and dried.

Here, commercially available dried products were purchased from the above-mentioned musk, antler, corn oil, angelica, ginseng, and bacon, and they were pulverized to have a particle size of about 100 to 150 mesh.

(Example 2)

10 g of the ginseng powder, 10 g of the ground powder, and 10 g of the flower larva powder were further mixed as the inner layer powder. At this time, commercially available dried ginseng and non-ginseng products were purchased and ground to a particle size of about 100 to 150 mesh. The larvae of the above-mentioned flowers are larvae which are washed for 1 day, washed, boiled in boiling water at 80 to 100 ° C for 5 minutes, dried for 10 minutes per 100g using a microwave of 700W, By weight.

(Example 3)

After molding the ring, 0.3 g of honey was applied to the outer surface of the ring, and Lactobacillus casei was inoculated at a concentration of 10 ⁵ cfu / g to the ring. After the application of the outer layer dough, the outer layer dough was inoculated with the lactobacillus casein at a concentration of 10 ⁵ cfu / g to the outer layer dough and fermented at 30 ° C for 20 days. Then, 0.3 g of the honey was again applied, and then it was naturally dried at room temperature.

(Example 4)

The same procedure as in Example 3 was carried out except that 10 g of the ginseng powder, 10 g of the ground powder and 10 g of the flower larva powder were further mixed as the inner layer powder. At this time, each powder was prepared in the same manner as in Example 2.

(Test Example 1) Experiments for improving memory performance in Examples 1 and 2

The ADAS-cog assay (Mohs et al., Psychopharmacol. Bull., 19) was used to determine whether the effect of memory and / or memory loss was protective after oral administration of the resonance terminal prepared in Examples 1 and 2 to people of 20 to 40 for 4 weeks. (3): 448-450, 1983). The test consisted of six areas (word recall, word delay recall, word recall, remembering test instructions, difficulty in finding words, listening comprehension, and summing up the scores of each area). 60 people were randomly assigned to the control group (20 patients), the treatment group (20 patients), and the treatment group (20 patients). The treated group 1 received the resonance end produced in Example 1 twice a day (one animal) for 12 weeks, and the treated group 2 received the resonance end produced in Example 2 twice a day (one aliquot) for 12 weeks The control group was made from wheat flour, and the honey on the surface was applied twice a day (one egg (about 5 g)) for 12 weeks. The results of the evaluation for effectiveness were respectively measured before administration and at 4 weeks after administration, and the results are shown in Table 1 below.

Test Example 1 Results. division
Control group Treatment group 1 (Example 1) Treatment group 2 (Example 2) Before administration After 4 weeks Before administration After 4 weeks Before administration After 4 weeks Word recall 5.30 5.28 5.32 4.22 5.29 4.01 Word delay recall 6.37 6.30 6.35 4.45 6.43 4.13 Word Recognition 4.50 4.48 4.51 3.73 4.35 3.31 Remember inspection instructions 0.38 0.40 0.39 0.17 0.31 0.14 Difficult to find words 0.21 0.15 0.25 0.00 0.25 0.00 Listening 0.15 0.13 0.17 0.02 0.15 0.00 Total score 16.91 16.74 16.99 12.59 16.79 11.59

As can be seen in the above Table 1, the ADAS-cog index was significantly decreased in all the treatment groups, while the control group showed almost no index variation.

(Test Example 2) Experiments for improving memory effect in Examples 3 and 4

In addition, the memory enhancing effect of Examples 3 and 4 was tested in the same manner as above, and the results are shown in Table 2 below.

Test Example 2 Results. division term Total score Treatment group 3 (Example 3)
Before administration 16.98 After 4 weeks 11.01 Treatment group 4 (Example 4)
Before administration 17.21 After 4 weeks 10.62 Control group
Before administration 17.05 After 4 weeks 16.25

As can be seen in Table 2, the ADAS-cog indexes were significantly reduced in all of the treatment groups, while the control group showed almost no index variation.

Therefore, it can be confirmed that the resonance end according to the present invention can improve the recognition ability and memory ability, and thus the learning ability can be improved.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the scope of the present invention is not limited to the disclosed exemplary embodiments. It will also be appreciated that many modifications and variations will be apparent to those skilled in the art without departing from the scope of the present invention.

Claims (4)

delete delete (a) an adhesive material containing omega-3 in liquid form is mixed and kneaded in an inner layer powder containing musk powder, antler powder, corn oil powder, Angelica keiskei powder, ginseng powder, ginseng powder, Step,
(b) mixing and kneading an adhesive material containing any one of honey, oligosaccharide, and syrup into an outer layer powder containing at least one of Baebongrise Powder, ground rice powder, Seokgupo Powder, Gugija Powder, Wow,
(c) molding the dough of step (a) into a ring-shaped inner layer,
(d) forming an outer layer by dough of the step (b) on the outer surface of the inner layer of the step (c)
After the step (c)
Further comprising the step of applying an adhesive material comprising any one of honey, oligosaccharide, and millet to the outer surface of the inner layer in step (c), and inoculating the Lactobacillus strain into the inner layer coated with the adhesive material,
After the step (d)
Inoculating the outer layer of step (d) with a lactobacillus strain;
Fermenting the molded product inoculated with the lactobacillus fungus at 20 to 40 DEG C for 5 to 30 days,
Further comprising the step of applying an adhesive material comprising any one of honey, oligosaccharide and millet to the surface of the fermented molding,
(A) comprises 50 to 100 parts by weight of antler grass powder, 50 to 100 parts by weight of corn oil powder, 50 to 100 parts by weight of Angelica powder, 50 to 100 parts by weight of ginseng powder, 50 to 100 parts by weight of the powder, 50 to 100 parts by weight of the ground powder, 50 to 100 parts by weight of the flower larvae, and 50 to 500 parts by weight of the adhesive material are mixed.
A resonance end for improving memory and learning ability, which is manufactured according to claim 3.