CN102793792B - Traditional Chinese medicine composition for treating porcine circovirus disease and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating porcine circovirus disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof. The traditional Chinese medicine composition comprises the following traditional Chinese medicines: astragalus root, iastis root, forsythia fruit, honeysuckle, cordyceps polysaccharide, codonopsitis, atractylodes rhizome, angelica, fresh rehmannia root, Chinese goldthread, grifola umbrellata, tuckahoe, white atractylodes rhizome, tangerine peel, and epimedium. The preparation method comprises the following steps: 1) respectively attritioning and screening various components except the cordyceps polysaccharide; 2) uniformly mixing the astragalus root, codonopsitis, forsythia fruit, atractylodes rhizome, angelica, grifola umbellate, tuckahoe with the cordyceps polysaccharide; 3) uniformly mixing the iastis root, honeysuckle, fresh rehmannia root, Chinese goldthread, white atractylodes rhizome, tangerine peel, and the epimedium; 4) uniformly mixing the medicine power obtained from the step 2) and the step 3), so as to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition is simply prepared, safe and reliable, and has no toxic and side effect, high bioavailability, and reliably and effectively prevents and treats the porcine circovirus disease, and moreover promotes the growth of the pit and is widely used in clinical.
Description
Technical field
The invention belongs to the veterinary drug technical field, be specifically related to a kind of Chinese medicine composition that is used for the treatment of Porcine circovirus desease and preparation method thereof.
Background technology
Porcine circovirus desease is the pig transmissible disease that is caused by porcine circovirus 2 type (PCV2), is newfound another important epidemic disease after pig breeding and breathing syndrome.Since Clark in 1997 etc. were separated to porcine circovirus 2 type first, this disease had caused huge economic loss for whole world pig industry.In the 20th international swine diseases conference in 2008, people more classify it as the No.1 epidemic disease of current harm pig industry development.China is since 2000 exist the serological evidence of PCV2 infection in the report swinery, and each department report that successively Epidemic Scope affects the whole country, swinery average positive rate 38.47%, and the pig farm positive rate is more than 58.75%, and harm is on the rise.
Pig circular ring virus is mainly encroached on the immune system of pig: virus accompanies with macrophage, mononuclear cell, histiocyte, nuclear thymus macrophage, causing suffering from the pig body condition descends, form immunosuppressant, owing to immunosuppressant causes immunodeficiency, its clinical manifestation is: the microorganism of low pathogenicity or attenuated vaccine can be diseases induced; Repeat morbidity to the treatment unresponsiveness; Vaccination there is not abundant immunne response; In a brood of pig, have unaccountable birth phase morbidity and dead occurs more than one; There is simultaneously the various diseases syndrome to occur in the swinery.Pig circular ring virus resistance to external world is stronger, is not inactivated for a long time in pH is 3 sour environment, and this virus is insensitive to chloroform, also can survive a period of time in hot environment.
At present, for Porcine circovirus desease mainly so that An ounce of prevention is worth a pound of cure.Be used for the undesirable and loose malicious danger of existence of the most effect of vaccine of prevention Porcine circovirus desease, the treatment Porcine circovirus desease generally adopts antimicrobial drug, such as florfenicol, gentamycin and sulfa drugs etc., produce easily drug residue and drug resistance, and antiviral agents such as ribavirin, amantadine etc. have been forbidden by the Ministry of Agriculture, and novel antiviral medicine such as interferon, immunoglobulin and transfer factor etc. exist that cost is high, effect is undesirable, have the defective such as potential risk.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition that is used for the treatment of Porcine circovirus desease, effectively prevent and treat Porcine circovirus desease, drug residue free has no side effect, and can promote the growth of pig.
Second purpose of the present invention provides a kind of preparation method that is used for the treatment of the Chinese medicine composition of Porcine circovirus desease.
In order to realize above purpose, the technical solution adopted in the present invention is: a kind of Chinese medicine composition that is used for the treatment of Porcine circovirus desease, the Chinese medicine compound of described compositions forms and mass fraction is: 10～25 parts of the Radixs Astragali, 10～25 parts of Radix Isatidis, 10～25 parts of Fructus Forsythiaes, 10～25 parts of Flos Loniceraes, 10～20 parts of Cordyceps polysaccharides, 5～10 parts of Radix Codonopsis, 5～10 parts of Rhizoma Atractylodis, 5～10 parts of Radix Angelicae Sinensis, 5～10 parts of Radix Rehmanniae, 5～10 parts of Rhizoma Coptidis, 3～5 parts of Polyporus, 3～5 parts in Poria, 3～5 parts of the Rhizoma Atractylodis Macrocephalaes, 3～5 parts of Pericarpium Citri Reticulataes, 3～5 parts of Herba Epimedii.
The Chinese medicine compound of described compositions forms and the preferred version of mass fraction is: 20 parts of the Radixs Astragali, 15 parts of Radix Isatidis, 10 parts of Fructus Forsythiaes, 20 parts of Flos Loniceraes, 15 parts of Cordyceps polysaccharides, 5 parts of Radix Codonopsis, 5 parts of Rhizoma Atractylodis, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Rehmanniae, 8 parts of Rhizoma Coptidis, 3 parts of Polyporus, 5 parts in Poria, 3 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts of Pericarpium Citri Reticulataes, 5 parts of Herba Epimedii.
A kind of preparation method that is used for the treatment of the Chinese medicine composition of Porcine circovirus desease may further comprise the steps:
1) except the various compositions that required Chinese medicine compound formed, Cordyceps polysaccharide, crosses screen cloth after the micronizing respectively;
2) take by weighing respectively in proportion the medicated powder Radix Astragali, Radix Codonopsis, Fructus Forsythiae, Rhizoma Atractylodis, Radix Angelicae Sinensis, Polyporus, Poria after sieving, evenly mix 10～15min with Cordyceps polysaccharide;
3) take by weighing respectively in proportion medicated powder Radix Isatidis, Flos Lonicerae, Radix Rehmanniae, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Herba Epimedii after sieving, evenly mix 10～15min;
4) with step 2) evenly mix 25～30min with the medicated powder of step 3) gained, namely get described Chinese medicine composition.
Described screen cloth is 800 orders.
Quality adding proportion when Chinese medicine composition of the present invention uses in feedstuff is 0.05～0.1%.
The compound recipe component drug characteristic of Chinese medicine composition of the present invention is as follows:
Cordyceps polysaccharide: one of main active of Cordyceps, can stimulate antibody to produce by activated macrophage, improve immunity of organisms, have in addition the respiratory system of improvement, suppress tumor growth, anti-stress, the pharmacological actions such as blood sugar lowering and slow down aging.
The Radix Astragali: sweet in the mouth, the feeble QI temperature, gas is thin and distinguish the flavor of densely, can rise and can fall, and the yang aspect of yang is also, and is nontoxic.Return lung, spleen, liver, kidney channel.Have enhancing human body immunity function and hemopoietic function, improve substance metabolism, the effects such as anti-stress and antiviral.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst.
Flos Lonicerae: the sweet cold of property fragrance, have the effects such as antibiotic, antiinflammatory, analgesic, enhancing immunity and antiendotoxin, be used for heat-clearing and toxic substances removing, diuresis is induced sweat.
Radix Isatidis: hardship, cold, cold, nontoxic.Return liver, the stomach warp.Have heat clearing away, antibiotic, antiviral, removing heat from blood, sore-throat relieving effect.Cure mainly anemopyretic cold, laryngopharynx swelling and pain, skin ulcer general edema with yellowish skin poison etc.
Fructus Forsythiae: bitter in the mouth, cold nature.Enter heart channel, lung meridian, small intestine meridian.Have heat-clearing and toxic substances removing, antibiotic, antiendotoxin protects the liver diuresis, and the effects such as analgesia, mass dissipating and swelling eliminating, dispelling wind and heat pathogens are told in the town.Cure mainly anemopyretic cold, laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore etc.
Radix Codonopsis: nature and flavor are sweet flat, little acid.Enter spleen channel, lung meridian.Invigorating the spleen and replenishing QI is arranged, the spleen invigorating lung benefiting, enhancing immunity strengthens the effects such as hematopoietic potential and anti-stress.Cure mainly weakness of the spleen and stomach, few food diarrhoea, the deficiency of vital energy are hung down and are taken off etc.
Rhizoma Coptidis: cold in nature, bitter in the mouth.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Have heat clearing and damp drying, eliminating fire and detoxication, antibiotic, the effects such as protozoacide.Be mainly used in damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire etc.
Herba Epimedii: hot, sweet, warm.Return liver, kidney channel.Has kidney-replenishing, bone and muscle strengthening, enhancing immunity, anti-inflammatory, antibacterial, the effect of wind-damp dispelling.It is soft to cure mainly the muscles and bones flaccidity, rheumatic arthralgia, numbness contracture etc.
Radix Rehmanniae: sweet, cold.Clearing away heat and cooling blood is arranged, the effects such as YIN nourishing and the production of body fluid promoting.Be mainly used in yin asthenia generating intrinsic heat, interior-heat is quenched one's thirst, laryngopharynx swelling and pain etc.
Rhizoma Atractylodis: hot, bitter, warm.Return spleen, stomach, Liver Channel.Have drying damp and strengthening spleen, expelling wind and cold, antibiotic antitumor, the effect such as make eye bright.Be used for the treatment of distension and fullness in the abdomen, the edema of having loose bowels, anemofrigid cold, nyctalopia etc.
Radix Angelicae Sinensis: sweet, hot, warm.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, enhancing immunity, loosening bowel to relieve constipation, the effect such as antiinflammatory is antibacterial.Be mainly used in blood deficiency and yellow complexion, dizzy cardiopalmus, dryness of the intestine constipation, the symptoms such as rheumatic arthralgia.
Polyporus: sweet, light, flat.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, immunostimulant, antibacterial, antitumor and hepatoprotective effect.The primary treatment dysuria, is had loose bowels at edema, and stranguria with turbid discharge is with inferior.
Poria: sweet, light, flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Have the eliminating dampness by diuresis diuresis, calmness, antibacterial, immunostimulant, antitumor, effect such as anticancer grade.Cure mainly: dysuria, the edema distension, the phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite is had loose bowels, and cough due to fluid-retention is anticancer etc.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antibiotic are arranged, antitumor, calmness, antiabortive effect.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Pericarpium Citri Reticulatae: temperature, hot, bitter.Enter spleen channel, stomach warp, lung meridian.Have regulating qi-flowing for strengthening spleen, in the accent, dampness is reduced phlegm, antiinflammatory, antiulcer effect.Cure mainly the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia, abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in the turbid damp resistance, phlegm-damp is stopped up the cough and asthma of lung.
The Chinese medicine composition that is used for the treatment of Porcine circovirus desease of the present invention has no side effect drug residue free, safe and reliable, micronizing in the preparation process, substep mixes, and medicament mixed is even, bioavailability is high, Porcine circovirus desease is had significant curative effect, and promote the growth of pig, preparation is simple, the medicine source is extensive, clinically extensive use.
The specific embodiment
The invention will be further described below in conjunction with embodiment:
Embodiment 1
A kind of Chinese medicine composition that is used for the treatment of Porcine circovirus desease, Chinese medicine compound consists of: Radix Astragali 10g, Radix Isatidis 10g, Fructus Forsythiae 10g, Flos Lonicerae 10g, Cordyceps polysaccharide 10g, Radix Codonopsis 5g, Rhizoma Atractylodis 5g, Radix Angelicae Sinensis 5g, Radix Rehmanniae 5g, Rhizoma Coptidis 5g, Polyporus 3g, Poria 3g, Rhizoma Atractylodis Macrocephalae 3g, Pericarpium Citri Reticulatae 3g, Herba Epimedii 3g.
The preparation method of this Chinese medicine composition may further comprise the steps:
1) except the various compositions that required Chinese medicine compound formed, Cordyceps polysaccharide, crosses 800 eye mesh screens after the micronizing respectively;
2) take by weighing respectively in proportion medicated powder Radix Astragali 10g, Radix Codonopsis 5g, Fructus Forsythiae 10g, Rhizoma Atractylodis 5g, Radix Angelicae Sinensis 5g, Polyporus 3g, Poria 3g after sieving, evenly mix 10min with Cordyceps polysaccharide 10g;
3) take by weighing respectively in proportion medicated powder Radix Isatidis 10g, Flos Lonicerae 10g, Radix Rehmanniae 5g, Rhizoma Coptidis 5g, Rhizoma Atractylodis Macrocephalae 3g, Pericarpium Citri Reticulatae 3g, Herba Epimedii 3g after sieving, evenly mix 10min;
4) with step 2) evenly mix 25min with the medicated powder of step 3) gained, namely get described Chinese medicine composition.
Embodiment 2
A kind of Chinese medicine composition that is used for the treatment of Porcine circovirus desease, Chinese medicine compound consists of: Radix Astragali 20g, Radix Isatidis 20g, Fructus Forsythiae 20g, Flos Lonicerae 20g, Cordyceps polysaccharide 15g, Radix Codonopsis 7g, Rhizoma Atractylodis 7g, Radix Angelicae Sinensis 7g, Radix Rehmanniae 7g, Rhizoma Coptidis 7g, Polyporus 4g, Poria 4g, Rhizoma Atractylodis Macrocephalae 4g, Pericarpium Citri Reticulatae 4g, Herba Epimedii 4g.
The preparation method of this Chinese medicine composition may further comprise the steps:
1) except the various compositions that required Chinese medicine compound formed, Cordyceps polysaccharide, crosses 800 eye mesh screens after the micronizing respectively;
2) take by weighing respectively in proportion medicated powder Radix Astragali 20g, Radix Codonopsis 7g, Fructus Forsythiae 20g, Rhizoma Atractylodis 7g, Radix Angelicae Sinensis 7g, Polyporus 4g, Poria 4g after sieving, evenly mix 13min with Cordyceps polysaccharide 15g;
3) take by weighing respectively in proportion medicated powder Radix Isatidis 20g, Flos Lonicerae 20g, Radix Rehmanniae 7g, Rhizoma Coptidis 7g, Rhizoma Atractylodis Macrocephalae 4g, Pericarpium Citri Reticulatae 4g, Herba Epimedii 4g after sieving, evenly mix 13min;
4) with step 2) evenly mix 28min with the medicated powder of step 3) gained, namely get described Chinese medicine composition.
Embodiment 3
A kind of Chinese medicine composition that is used for the treatment of Porcine circovirus desease, Chinese medicine compound consists of: Radix Astragali 25g, Radix Isatidis 25g, Fructus Forsythiae 25g, Flos Lonicerae 25g, Cordyceps polysaccharide 20g, Radix Codonopsis 10g, Rhizoma Atractylodis 10g, Radix Angelicae Sinensis 10g, Radix Rehmanniae 10g, Rhizoma Coptidis 10g, Polyporus 5g, Poria 5g, Rhizoma Atractylodis Macrocephalae 5g, Pericarpium Citri Reticulatae 5g, Herba Epimedii 5g.
The preparation method of this Chinese medicine composition may further comprise the steps:
1) except the various compositions that required Chinese medicine compound formed, Cordyceps polysaccharide, crosses 800 eye mesh screens after the micronizing respectively;
2) take by weighing respectively in proportion medicated powder Radix Astragali 25g, Radix Codonopsis 10g, Fructus Forsythiae 25g, Rhizoma Atractylodis 10g, Radix Angelicae Sinensis 10g, Polyporus 5g, Poria 5g after sieving, evenly mix 15min with Cordyceps polysaccharide 20g;
3) take by weighing respectively in proportion medicated powder Radix Isatidis 25g, Flos Lonicerae 25g, Radix Rehmanniae 10g, Rhizoma Coptidis 10g, Rhizoma Atractylodis Macrocephalae 5g, Pericarpium Citri Reticulatae 5g, Herba Epimedii 5g after sieving, evenly mix 15min;
4) with step 2) evenly mix 30min with the medicated powder of step 3) gained, namely get described Chinese medicine composition.
Embodiment 4
As preferred version of the present invention, the compound recipe of Chinese medicine composition consists of: Radix Astragali 20g, Radix Isatidis 15g, Fructus Forsythiae 10g, Flos Lonicerae 20g, Cordyceps polysaccharide 15g, Radix Codonopsis 5g, Rhizoma Atractylodis 5g, Radix Angelicae Sinensis 5g, Radix Rehmanniae 5g, Rhizoma Coptidis 8g, Polyporus 3g, Poria 5g, Rhizoma Atractylodis Macrocephalae 3g, Pericarpium Citri Reticulatae 3g, Herba Epimedii 5g.
The preparation method of this Chinese medicine composition may further comprise the steps:
1) except the various compositions that required Chinese medicine compound formed, Cordyceps polysaccharide, crosses 800 eye mesh screens after the micronizing respectively;
2) take by weighing respectively in proportion medicated powder Radix Astragali 20g, Radix Codonopsis 5g, Fructus Forsythiae 10g, Rhizoma Atractylodis 5g, Radix Angelicae Sinensis 5g, Polyporus 3g, Poria 5g after sieving, evenly mix 15min with Cordyceps polysaccharide 15g;
3) take by weighing respectively in proportion medicated powder Radix Isatidis 15g, Flos Lonicerae 20g, Radix Rehmanniae 5g, Rhizoma Coptidis 8g, Rhizoma Atractylodis Macrocephalae 3g, Pericarpium Citri Reticulatae 3g, Herba Epimedii 5g after sieving, evenly mix 15min;
4) with step 2) evenly mix 30min with the medicated powder of step 3) gained, namely get described Chinese medicine composition.
Clinical trial
The generation Porcine circovirus desease has been made a definite diagnosis through means such as clinical symptoms diagnosis, laboratory diagnosiss in the pig farm, Henan.Random choose is 100 from sick swinery, male and female has concurrently, and pig individual weight and the mental status selected are similar, is divided into four groups, record respectively the body weight of every group of pig, use the embodiment of the invention 1～4 made Chinese medicine composition and commercially available Western medicine (breathing heavily the gram element) to treat.Commercially available Western medicine operates in strict accordance with its explanation, and the use amount of Chinese medicine composition of the present invention is: every 200kg feedstuff adds Chinese medicine composition 100g, every day 3～4 times, is used in conjunction 14.
Commercially available Western medicine and this preparation clinical trial situation statistical table
This clinical test results by statistics Epidemiological Analysis is found: Chinese medicine composition of the present invention and commercially available Western medicine be difference on effect extremely remarkable (P＜0.01) aspect the treatment Porcine circovirus desease.Chinese medicine composition of the present invention to the cure rate of circovirus disease more than 70%, and to ill pig more after recover to have good facilitation.
Claims (4)
1. Chinese medicine composition that is used for the treatment of Porcine circovirus desease is characterized in that: the Chinese medicine compound of described compositions forms and mass fraction is: 10～25 parts of the Radixs Astragali, 10～25 parts of Radix Isatidis, 10～25 parts of Fructus Forsythiaes, 10～25 parts of Flos Loniceraes, 10～20 parts of Cordyceps polysaccharides, 5～10 parts of Radix Codonopsis, 5～10 parts of Rhizoma Atractylodis, 5～10 parts of Radix Angelicae Sinensis, 5～10 parts of Radix Rehmanniae, 5～10 parts of Rhizoma Coptidis, 3～5 parts of Polyporus, 3～5 parts in Poria, 3～5 parts of the Rhizoma Atractylodis Macrocephalaes, 3～5 parts of Pericarpium Citri Reticulataes, 3～5 parts of Herba Epimedii.
2. the Chinese medicine composition that is used for the treatment of Porcine circovirus desease according to claim 1 is characterized in that: the Chinese medicine compound of described compositions forms and the preferred version of mass fraction is: 20 parts of the Radixs Astragali, 15 parts of Radix Isatidis, 10 parts of Fructus Forsythiaes, 20 parts of Flos Loniceraes, 15 parts of Cordyceps polysaccharides, 5 parts of Radix Codonopsis, 5 parts of Rhizoma Atractylodis, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Rehmanniae, 8 parts of Rhizoma Coptidis, 3 parts of Polyporus, 5 parts in Poria, 3 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts of Pericarpium Citri Reticulataes, 5 parts of Herba Epimedii.
3. preparation method that is used for the treatment of the Chinese medicine composition of Porcine circovirus desease as claimed in claim 1 or 2 is characterized in that: may further comprise the steps:
1) except the various compositions that required Chinese medicine compound formed, Cordyceps polysaccharide, crosses screen cloth after the micronizing respectively;
2) take by weighing respectively in proportion the medicated powder Radix Astragali, Radix Codonopsis, Fructus Forsythiae, Rhizoma Atractylodis, Radix Angelicae Sinensis, Polyporus, Poria after sieving, evenly mix 10～15min with Cordyceps polysaccharide;
3) take by weighing respectively in proportion medicated powder Radix Isatidis, Flos Lonicerae, Radix Rehmanniae, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Herba Epimedii after sieving, evenly mix 10～15min;
4) with step 2) evenly mix 25～30min with the medicated powder of step 3) gained, namely get described Chinese medicine composition.
4. the preparation method that is used for the treatment of the Chinese medicine composition of Porcine circovirus desease according to claim 3, it is characterized in that: described screen cloth is 800 orders.
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| CN104161209B (en) * | 2013-07-22 | 2016-06-08 | 河南联合英伟饲料有限公司 | A kind of have the feed additive of immunological enhancement, preparation method and application |
| CN105079177A (en) * | 2014-05-13 | 2015-11-25 | 重庆美德实业集团有限公司 | Chinese herbal preparation capable of preventing and controlling porcine cytomegaloviral disease and porcine circovirus disease |
| CN104522364A (en) * | 2014-12-14 | 2015-04-22 | 河南联合英伟饲料有限公司 | Medicine-core type feed resistant to swine viral diseases and preparation method of medicine-core type feed |
| CN107875253A (en) * | 2017-11-30 | 2018-04-06 | 南宁学院 | A kind of composition for treating Porcine circovirus desease and preparation method thereof |
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Effective date of registration: 20211216 Address after: 463000 Zhumadian Industrial Park, Henan Province Patentee after: HENAN HOUYI PHARMACY CO.,LTD. Address before: 451162 Henan Zhengzhou Zhengzhou airport comprehensive economic experimentation area, Xingang Avenue East Patentee before: HENAN HOUYI INDUSTRIAL GROUP CO.,LTD. |
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