CN103211985B - Traditional Chinese medicine for treating infectious serositis of duck - Google Patents
Traditional Chinese medicine for treating infectious serositis of duck Download PDFInfo
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- CN103211985B CN103211985B CN201310162466.7A CN201310162466A CN103211985B CN 103211985 B CN103211985 B CN 103211985B CN 201310162466 A CN201310162466 A CN 201310162466A CN 103211985 B CN103211985 B CN 103211985B
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Abstract
The invention provides a traditional Chinese medicine for treating infectious serositis of duck. The raw material medicines of the traditional Chinese medicine comprise jasmine, radix scrophulariae, root of common peony, Coptis chinensis, cassia twig, Rhizoma Osmundae, solanum lyratum, asiatic toddalia root, tabasheer, Philippine flemingia root, hedyotis hedyotidea, Rhizoma Atractylodis Macrocephalae, Angelica sinensis, honeysuckle, seed of feather cockscomb, acanthopanax, abrus cantoniensis hance, Polygonum cuspidatum, sargentgloryvine stem, groundsel, glossy privet fruit, verbena, Brucea javanica, Chinese Tamarisk Twig, moutan bark, madder, pericarpium citri reticulatae, sealwort and sealwort. The traditional Chinese medicine has the advantages of no toxicity, no harmful residue, environmental friendliness and no tolerance, and has remarkable effect for treating infectious serositis of duck.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind for the treatment of Chinese medicine of infectious serositis in duck.
Background technology
Infectious serositis in duck is that one of duck industry infectious disease the most serious is supported in the harm caused by riemerella anatipestifer (Riemerella anatipestifer, RA).This disease makes duck mortality rate high, acute or chronic septicemia process, with fibrinous pericarditis, perihepatitis, airsacculitis, meningitis and caseous salpingitis for feature, 1-8 duck in age in week is responsive, rugged environment condition can inspire primary disease, and mortality rate reaches as high as 75%.The duck main manifestations of chronic disease is meningitis symptom, i.e. torticollis, causes residual duck or stiff duck, supports duck industry cause huge economic loss to the whole world.It is reported, external infectious serositis in duck has 21 kinds of serotypes, and China at least exists 25 kinds of serotypes.Because the serotype of this bacterium is more, resistant rate high and extensively, cross resistance is many, after the course for the treatment of of a kind of drug use, its effect has reduced or without much effects, vaccine, medical treatment effect are still undesirable greatly.
This sick clinical manifestation is that most acute is often without any symptom sudden death.Acute case is more common in the young duck in 2 ~ 3 week age, shows as cough, sneeze.Eye, nose flow out serosity or sticky discharge, and feather adhesion or come off around eye socket, forms eyelet.Feces is thin in green or yellow green.Movement disorder, head and neck trembles or lethargy, the nervous symptoms before occurring opisthotonus on one's deathbed or turn-take, the course of disease 1 ~ 3d.Subacute or chronic cases, is more common in children duck in 4 ~ 6 week age, about course of disease 15d.Show as lassitude, peel off slow-witted vertical, somnolence, necking down or mouth support ground, and lower limb is soft, is reluctant to walk about, and ataxia not easily resets after overturning.Shake the head or nod, also showing head and neck crooked, constantly piping when meeting agitation, loss of appetite or do not eat, to become thin gradually and dead.Although the survival had, dysplasia.
The most obvious naked eyes pathological changes of this pathology suffers from duck whole body serosal surface to have fibrinous exudate, the most obvious with fibrinous pericarditis, perihepatitis, airsacculitis.Have the meningitis seen and the cerebrovascular hyperemia of nervous symptoms, pericardial fluid increases, in cotton-shaped.Hepatomegaly, in khaki, matter is crisp.Air bag is muddy, and airbag wall thickens.Gollbladder dilation, tarsal joint swelling, that touches has fluctuation, and joint fluid increases, sticky, is creamy white.Chronic cases can see cellulosic suppurative hepatitis and meningitis, splenomegaly, and there are canescence speckle and cheesy salpingitis and arthritis etc. in surface.
Relative to Western medicine, it is high that Chinese medicine has overall curative effect, not easily produce the advantages such as drug resistance, significant inhibitory action is had to the growth and reproduction of the cause of disease such as antibacterial, virus, even reach the pharmacological effect killing cause of disease, and can regulate, promote the immunologic function of body, there is the effect of non-specific resisting pathogenic microbes.In recent years, Chinese herb prevention livestock and poultry has obtained certain achievement, causes the great attention of researcher.
Chinese herbal medicine all has inhibitory action in various degree to the staphylococcus causing duck to infect, escherichia coli, Bacillus typhi, dysentery bacterium etc., riemerella anatipestifer is the bacillus of a kind of gram-negative, anaerobic type and anodontia spore, much antipyretic and antidotal type Chinese medicine all has antibacterial activity to gram positive bacteria or gram negative bacteria, and it is nontoxic, imperative without hazard residue, environmental protection, the Chinese medicine not producing patience or tcm product thus to develop.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine preparation being used for the treatment of infectious serositis in duck, its have nontoxic, without hazard residue, environmental protection, do not produce the advantage of patience, to the treatment of infectious serositis in duck, there is remarkable result.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine being used for the treatment of infectious serositis in duck, its crude drug comprises Fructus Gardeniae, Radix Scrophulariae, Radix Paeoniae Rubra, Rhizoma Coptidis, Ramulus Cinnamomi, Rhizoma Osmundae Japonicae, Herba Solani Lyrati, Radix Toddaliae Asiaticae, Concretio Silicea Bambusae, Radix Flemingiae Philippinensis, Caulis et Folium hedyotis hedyotideae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Flos Lonicerae, Semen Celosiae, Radix Et Caulis Acanthopanacis Senticosi, Herba Abri, Rhizoma Polygoni Cuspidati, Caulis Sargentodoxae, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Verbenae, Fructus Bruceae, Cacumen Tamaricis, Cortex Moutan, Radix Rubiae, Pericarpium Citri Reticulatae, Rhizoma Polygonati and Radix Glycyrrhizae.
Wherein, the weight portion of each crude drug is respectively Fructus Gardeniae 50 weight portion ~ 60 weight portion, Radix Scrophulariae 25 weight portion ~ 35 weight portion, Radix Paeoniae Rubra 30 weight portion ~ 40 weight portion, Rhizoma Coptidis 80 weight portion ~ 90 weight portion, Ramulus Cinnamomi 30 weight portion ~ 40 weight portion, Rhizoma Osmundae Japonicae 50 weight portion ~ 60 weight portion, Herba Solani Lyrati 20 weight portion ~ 30 weight portion, Radix Toddaliae Asiaticae 35 weight portion ~ 45 weight portion, Concretio Silicea Bambusae 30 weight portion ~ 40 weight portion, Radix Flemingiae Philippinensis 20 weight portion ~ 30 weight portion, Caulis et Folium hedyotis hedyotideae 35 weight portion ~ 45 weight portion, the Rhizoma Atractylodis Macrocephalae 45 weight portion ~ 55 weight portion, Radix Angelicae Sinensis 30 weight portion ~ 40 weight portion, Flos Lonicerae 65 weight portion ~ 75 weight portion, Semen Celosiae 20 weight portion ~ 30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion ~ 45 weight portion, Herba Abri 25 weight portion ~ 35 weight portion, Rhizoma Polygoni Cuspidati 40 weight portion ~ 50 weight portion, Caulis Sargentodoxae 25 weight portion ~ 35 weight portion, Herba Senecionis Scandentis 15 weight portion ~ 25 weight portion, Fructus Ligustri Lucidi 25 weight portion ~ 35 weight portion, Herba Verbenae 20 weight portion ~ 30 weight portion, Fructus Bruceae 30 weight portion ~ 40 weight portion, Cacumen Tamaricis 30 weight portion ~ 40 weight portion, Cortex Moutan 25 weight portion ~ 35 weight portion, Radix Rubiae 20 weight portion ~ 30 weight portion, Pericarpium Citri Reticulatae 10 weight portion ~ 20 weight portion, Rhizoma Polygonati 50 weight portion ~ 60 weight portion and Radix Glycyrrhizae 20 weight portion ~ 30 weight portion.
Wherein, the weight portion of each crude drug is respectively Fructus Gardeniae 53 weight portion ~ 57 weight portion, Radix Scrophulariae 28 weight portion ~ 32 weight portion, Radix Paeoniae Rubra 33 weight portion ~ 37 weight portion, Rhizoma Coptidis 83 weight portion ~ 87 weight portion, Ramulus Cinnamomi 33 weight portion ~ 37 weight portion, Rhizoma Osmundae Japonicae 53 weight portion ~ 57 weight portion, Herba Solani Lyrati 23 weight portion ~ 27 weight portion, Radix Toddaliae Asiaticae 38 weight portion ~ 42 weight portion, Concretio Silicea Bambusae 33 weight portion ~ 37 weight portion, Radix Flemingiae Philippinensis 23 weight portion ~ 27 weight portion, Caulis et Folium hedyotis hedyotideae 38 weight portion ~ 42 weight portion, the Rhizoma Atractylodis Macrocephalae 48 weight portion ~ 52 weight portion, Radix Angelicae Sinensis 33 weight portion ~ 37 weight portion, Flos Lonicerae 68 weight portion ~ 72 weight portion, Semen Celosiae 23 weight portion ~ 27 weight portion, Radix Et Caulis Acanthopanacis Senticosi 38 weight portion ~ 42 weight portion, Herba Abri 28 weight portion ~ 32 weight portion, Rhizoma Polygoni Cuspidati 43 weight portion ~ 47 weight portion, Caulis Sargentodoxae 28 weight portion ~ 32 weight portion, Herba Senecionis Scandentis 18 weight portion ~ 22 weight portion, Fructus Ligustri Lucidi 28 weight portion ~ 32 weight portion, Herba Verbenae 23 weight portion ~ 27 weight portion, Fructus Bruceae 33 weight portion ~ 37 weight portion, Cacumen Tamaricis 33 weight portion ~ 37 weight portion, Cortex Moutan 28 weight portion ~ 32 weight portion, Radix Rubiae 23 weight portion ~ 27 weight portion, Pericarpium Citri Reticulatae 13 weight portion ~ 17 weight portion, Rhizoma Polygonati 53 weight portion ~ 57 weight portion and Radix Glycyrrhizae 23 weight portion ~ 27 weight portion.
Wherein, the weight portion of each crude drug is respectively Fructus Gardeniae 55 weight portion, Radix Scrophulariae 30 weight portion, Radix Paeoniae Rubra 35 weight portion, Rhizoma Coptidis 85 weight portion, Ramulus Cinnamomi 35 weight portion, Rhizoma Osmundae Japonicae 55 weight portion, Herba Solani Lyrati 25 weight portion, Radix Toddaliae Asiaticae 40 weight portion, Concretio Silicea Bambusae 35 weight portion, Radix Flemingiae Philippinensis 25 weight portion, Caulis et Folium hedyotis hedyotideae 40 weight portion, the Rhizoma Atractylodis Macrocephalae 50 weight portion, Radix Angelicae Sinensis 35 weight portion, Flos Lonicerae 70 weight portion, Semen Celosiae 25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 40 weight portion, Herba Abri 30 weight portion, Rhizoma Polygoni Cuspidati 45 weight portion, Caulis Sargentodoxae 30 weight portion, Herba Senecionis Scandentis 20 weight portion, Fructus Ligustri Lucidi 30 weight portion, Herba Verbenae 25 weight portion, Fructus Bruceae 35 weight portion, Cacumen Tamaricis 35 weight portion, Cortex Moutan 30 weight portion, Radix Rubiae 25 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Rhizoma Polygonati 55 weight portion and Radix Glycyrrhizae 25 weight portion.
Present invention also offers the preparation method of above-mentioned Chinese medicine, described Chinese drug preparation becomes decocting liquid, it is specially and described component is mixed in proportion, and decocts with water three times after pulverizing, and first time adds the pure water relative to raw medicinal material quality 10 ~ 12 times amount, second and third time is the pure water of 8 ~ 10 times amount, each decoction 1 hour, collecting decoction, filters, concentrated remove portion water, obtaining crude drug concentration is the decocting liquid of 1g/ml ~ 2g/ml.
Present invention also offers the preparation method of above-mentioned Chinese medicine, described Chinese drug preparation becomes Chinese medicinal powder feed additive, it is specially and described component is mixed in proportion, the pure water relative to raw medicinal material quality 10 ~ 12 times amount is added after pulverizing, after jolting mixing, soak 30 ~ 40min, connect reflux condensing tube, be heated to boiling, and keep 100 DEG C micro-ly to boil 2 hours, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the first filtrate, filtering residue adds relative to raw medicinal material quality 8 ~ 10 times of quality pure water again, after jolting mixing, soak 30min ~ 40min, connect reflux condensing tube, be heated to 100 DEG C of boilings, and keep 1 hour, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, when being evaporated to 70 DEG C, relative density is the clear paste of 1.10 ~ 1.15, be cooled to room temperature, add determining alcohol be 70% ~ 80% ethanol make alcohol content reach 70 ~ 80wt%, stir evenly, leave standstill and be no less than 12h, filter precipitation, during supernatant recovery ethanol to 70 DEG C, relative density is the clear paste of 1.20 ~ 1.25, use cyclohexane extraction, ethyl acetate, n-butyl alcohol extracts it successively, and reclaim under reduced pressure wherein organic solvent, obtain and get dry extract, be ground into powder, dry, obtain Chinese medicinal powder feed additive.
Present invention also offers a kind of feedstuff being used for the treatment of infectious serositis in duck, it comprises: Semen Maydis, bean cake, Sal, calcium carbonate, calcium hydrogen phosphate, vitamin mixtures additive, trace mineral supplement, ispol additive and above-mentioned Chinese medicinal powder feed additive.
In described feedstuff, the weight portion of each component is Semen Maydis 60 ~ 70 weight portion, bean cake 15 ~ 25 weight portion, Sal 1 ~ 3 weight portion, calcium carbonate 3 ~ 6 weight portion, calcium hydrogen phosphate 2 ~ 4 weight portion, vitamin mixtures additive 2 ~ 4 weight portion, trace mineral supplement 1 ~ 3 weight portion, ispol additive 2 ~ 4 weight portion and Chinese medicinal powder feed additive 10 ~ 14 weight portion.
Present invention also offers the preparation method of above-mentioned feedstuff, be specially:
The first step, is mixed in proportion Semen Maydis and bean cake, and the water adding 1/3 ~ 1/2 of the mixture quality formed relative to Semen Maydis and bean cake stirs, be heated to 60 ~ 100 DEG C, be sprinkled into Sal in proportion, after cooling, load in container, put into 20 ~ 30cm depths, underground, said mixture layering loads in container, compacting layer by layer, until 10 ~ 25 centimetres above ground level, plastic covering film phonograph seal, ferments 4 ~ 8 days, obtains fermentation product;
Second step, prepares Chinese medicinal powder feed additive according to the method described above;
3rd step, by fermentation product prepared by calcium carbonate, calcium hydrogen phosphate, vitamin mixtures additive, trace mineral supplement, ispol additive and the first step, Chinese medicinal powder feed additive prepared by second step is sent in blender in proportion and is stirred, send in pulverizer subsequently and carry out primary comminution, mixture after pulverizing is sent in super micron mill and carries out separating twice, obtain fine grained, the fine grained after pulverizing to get product feedstuff after sterilization, sealing, pack.
Beneficial effect of the present invention:
The Chinese medicine preparation being used for the treatment of infectious serositis in duck provided by the invention have nontoxic, without hazard residue, environmental protection, do not produce the advantage of patience, to the treatment of infectious serositis in duck, there is remarkable result.
Detailed description of the invention
The invention provides a kind of Chinese medicine being used for the treatment of infectious serositis in duck, its crude drug comprises Fructus Gardeniae, Radix Scrophulariae, Radix Paeoniae Rubra, Rhizoma Coptidis, Ramulus Cinnamomi, Rhizoma Osmundae Japonicae, Herba Solani Lyrati, Radix Toddaliae Asiaticae, Concretio Silicea Bambusae, Radix Flemingiae Philippinensis, Caulis et Folium hedyotis hedyotideae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Flos Lonicerae, Semen Celosiae, Radix Et Caulis Acanthopanacis Senticosi, Herba Abri, Rhizoma Polygoni Cuspidati, Caulis Sargentodoxae, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Verbenae, Fructus Bruceae, Cacumen Tamaricis, Cortex Moutan, Radix Rubiae, Pericarpium Citri Reticulatae, Rhizoma Polygonati and Radix Glycyrrhizae.
Preferably, described Chinese medicine is only made up of above-mentioned raw materials medicine.
Wherein, the weight portion of each crude drug is respectively Fructus Gardeniae 50 weight portion ~ 60 weight portion, Radix Scrophulariae 25 weight portion ~ 35 weight portion, Radix Paeoniae Rubra 30 weight portion ~ 40 weight portion, Rhizoma Coptidis 80 weight portion ~ 90 weight portion, Ramulus Cinnamomi 30 weight portion ~ 40 weight portion, Rhizoma Osmundae Japonicae 50 weight portion ~ 60 weight portion, Herba Solani Lyrati 20 weight portion ~ 30 weight portion, Radix Toddaliae Asiaticae 35 weight portion ~ 45 weight portion, Concretio Silicea Bambusae 30 weight portion ~ 40 weight portion, Radix Flemingiae Philippinensis 20 weight portion ~ 30 weight portion, Caulis et Folium hedyotis hedyotideae 35 weight portion ~ 45 weight portion, the Rhizoma Atractylodis Macrocephalae 45 weight portion ~ 55 weight portion, Radix Angelicae Sinensis 30 weight portion ~ 40 weight portion, Flos Lonicerae 65 weight portion ~ 75 weight portion, Semen Celosiae 20 weight portion ~ 30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion ~ 45 weight portion, Herba Abri 25 weight portion ~ 35 weight portion, Rhizoma Polygoni Cuspidati 40 weight portion ~ 50 weight portion, Caulis Sargentodoxae 25 weight portion ~ 35 weight portion, Herba Senecionis Scandentis 15 weight portion ~ 25 weight portion, Fructus Ligustri Lucidi 25 weight portion ~ 35 weight portion, Herba Verbenae 20 weight portion ~ 30 weight portion, Fructus Bruceae 30 weight portion ~ 40 weight portion, Cacumen Tamaricis 30 weight portion ~ 40 weight portion, Cortex Moutan 25 weight portion ~ 35 weight portion, Radix Rubiae 20 weight portion ~ 30 weight portion, Pericarpium Citri Reticulatae 10 weight portion ~ 20 weight portion, Rhizoma Polygonati 50 weight portion ~ 60 weight portion and Radix Glycyrrhizae 20 weight portion ~ 30 weight portion.
Wherein, the weight portion of each crude drug is preferably respectively Fructus Gardeniae 53 weight portion ~ 57 weight portion further, Radix Scrophulariae 28 weight portion ~ 32 weight portion, Radix Paeoniae Rubra 33 weight portion ~ 37 weight portion, Rhizoma Coptidis 83 weight portion ~ 87 weight portion, Ramulus Cinnamomi 33 weight portion ~ 37 weight portion, Rhizoma Osmundae Japonicae 53 weight portion ~ 57 weight portion, Herba Solani Lyrati 23 weight portion ~ 27 weight portion, Radix Toddaliae Asiaticae 38 weight portion ~ 42 weight portion, Concretio Silicea Bambusae 33 weight portion ~ 37 weight portion, Radix Flemingiae Philippinensis 23 weight portion ~ 27 weight portion, Caulis et Folium hedyotis hedyotideae 38 weight portion ~ 42 weight portion, the Rhizoma Atractylodis Macrocephalae 48 weight portion ~ 52 weight portion, Radix Angelicae Sinensis 33 weight portion ~ 37 weight portion, Flos Lonicerae 68 weight portion ~ 72 weight portion, Semen Celosiae 23 weight portion ~ 27 weight portion, Radix Et Caulis Acanthopanacis Senticosi 38 weight portion ~ 42 weight portion, Herba Abri 28 weight portion ~ 32 weight portion, Rhizoma Polygoni Cuspidati 43 weight portion ~ 47 weight portion, Caulis Sargentodoxae 28 weight portion ~ 32 weight portion, Herba Senecionis Scandentis 18 weight portion ~ 22 weight portion, Fructus Ligustri Lucidi 28 weight portion ~ 32 weight portion, Herba Verbenae 23 weight portion ~ 27 weight portion, Fructus Bruceae 33 weight portion ~ 37 weight portion, Cacumen Tamaricis 33 weight portion ~ 37 weight portion, Cortex Moutan 28 weight portion ~ 32 weight portion, Radix Rubiae 23 weight portion ~ 27 weight portion, Pericarpium Citri Reticulatae 13 weight portion ~ 17 weight portion, Rhizoma Polygonati 53 weight portion ~ 57 weight portion and Radix Glycyrrhizae 23 weight portion ~ 27 weight portion.
Wherein, the weight portion of each crude drug is most preferably respectively Fructus Gardeniae 55 weight portion, Radix Scrophulariae 30 weight portion, Radix Paeoniae Rubra 35 weight portion, Rhizoma Coptidis 85 weight portion, Ramulus Cinnamomi 35 weight portion, Rhizoma Osmundae Japonicae 55 weight portion, Herba Solani Lyrati 25 weight portion, Radix Toddaliae Asiaticae 40 weight portion, Concretio Silicea Bambusae 35 weight portion, Radix Flemingiae Philippinensis 25 weight portion, Caulis et Folium hedyotis hedyotideae 40 weight portion, the Rhizoma Atractylodis Macrocephalae 50 weight portion, Radix Angelicae Sinensis 35 weight portion, Flos Lonicerae 70 weight portion, Semen Celosiae 25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 40 weight portion, Herba Abri 30 weight portion, Rhizoma Polygoni Cuspidati 45 weight portion, Caulis Sargentodoxae 30 weight portion, Herba Senecionis Scandentis 20 weight portion, Fructus Ligustri Lucidi 30 weight portion, Herba Verbenae 25 weight portion, Fructus Bruceae 35 weight portion, Cacumen Tamaricis 35 weight portion, Cortex Moutan 30 weight portion, Radix Rubiae 25 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Rhizoma Polygonati 55 weight portion and Radix Glycyrrhizae 25 weight portion.
Present invention also offers the preparation method of above-mentioned Chinese medicine, described Chinese drug preparation becomes decocting liquid, it is specially and described component is mixed in proportion, and decocts with water three times after pulverizing, and first time adds the pure water relative to raw medicinal material quality 10 ~ 12 times amount, second and third time is the pure water of 8 ~ 10 times amount, each decoction 1 hour, collecting decoction, filters, concentrated remove portion water, obtaining crude drug concentration is the decocting liquid of 1g/ml ~ 2g/ml.
Present invention also offers the preparation method of above-mentioned Chinese medicine, described Chinese drug preparation becomes Chinese medicinal powder feed additive, it is specially and described component is mixed in proportion, the pure water relative to raw medicinal material quality 10 ~ 12 times amount is added after pulverizing, after jolting mixing, soak 30 ~ 40min, connect reflux condensing tube, be heated to boiling, and keep 100 DEG C micro-ly to boil 2 hours, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the first filtrate, filtering residue adds relative to raw medicinal material quality 8 ~ 10 times of quality pure water again, after jolting mixing, soak 30min ~ 40min, connect reflux condensing tube, be heated to 100 DEG C of boilings, and keep 1 hour, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, when being evaporated to 70 DEG C, relative density is the clear paste of 1.10 ~ 1.15, be cooled to room temperature, add determining alcohol be 70% ~ 80% ethanol make alcohol content reach 70 ~ 80wt%, stir evenly, leave standstill and be no less than 12h, filter precipitation, during supernatant recovery ethanol to 70 DEG C, relative density is the clear paste of 1.20 ~ 1.25, use cyclohexane extraction, ethyl acetate, n-butyl alcohol extracts it successively, and reclaim under reduced pressure wherein organic solvent, obtain and get dry extract, be ground into powder, dry, obtain Chinese medicinal powder feed additive.
Present invention also offers a kind of feedstuff being used for the treatment of infectious serositis in duck, it comprises: Semen Maydis, bean cake, Sal, calcium carbonate, calcium hydrogen phosphate, vitamin mixtures additive, trace mineral supplement, ispol additive and above-mentioned Chinese medicinal powder feed additive.
Preferably, described feedstuff is only made up of said components.
In described feedstuff, the weight portion of each component is Semen Maydis 60 ~ 70 weight portion, bean cake 15 ~ 25 weight portion, Sal 1 ~ 3 weight portion, calcium carbonate 3 ~ 6 weight portion, calcium hydrogen phosphate 2 ~ 4 weight portion, vitamin mixtures additive 2 ~ 4 weight portion, trace mineral supplement 1 ~ 3 weight portion, ispol additive 2 ~ 4 weight portion and Chinese medicinal powder feed additive 10 ~ 14 weight portion.
In described feedstuff, the weight portion of each component most preferably is Semen Maydis 65 weight portion, bean cake 20 weight portion, Sal 2 weight portion, calcium carbonate 5 weight portion, calcium hydrogen phosphate 3 weight portion, vitamin mixtures additive 3 weight portion, trace mineral supplement 2 weight portion, amino-acid trace element complex 2 weight portion, ispol additive 3 weight portion and Chinese medicinal powder feed additive 12 weight portion.
Described trace mineral supplement comprises one or more mixing in ferrous sulfate, curpic carbonate, manganese sulfate, zinc sulfate, sodium selenite.
Described trace mineral supplement also uses composite additive of trace elements, as M-P (microelement pre-mix material that Qingdao and company of U.S. produce).
Described vitamin mixtures additive comprises vitamin D, vitamin B6, vitamin B2, one or more mixing in vitamin K, vitamin A, folic acid, nicotinic acid.
Described vitamin mixtures additive also can adopt vitamin mixtures premix material, as LV62 (vitamin premix that Qingdao and company of U.S. produce).
Described ispol additive comprises one or more mixing in lysine, methionine, threonine, tryptophan, cystine or arginine.
Present invention also offers the preparation method of above-mentioned feedstuff, be specially:
The first step, is mixed in proportion Semen Maydis and bean cake, and the water adding 1/3 ~ 1/2 of the mixture quality formed relative to Semen Maydis and bean cake stirs, be heated to 60 ~ 80 DEG C, be sprinkled into Sal in proportion, after cooling, load in container, put into 20 ~ 30cm depths, underground, said mixture layering loads in container, compacting layer by layer, until 10 ~ 25 centimetres above ground level, plastic covering film phonograph seal, ferments 4 ~ 8 days, obtains fermentation product;
Second step, prepares Chinese medicinal powder feed additive according to the method described above;
3rd step, by fermentation product prepared by calcium carbonate, calcium hydrogen phosphate, vitamin mixtures additive, trace mineral supplement, ispol additive and the first step, Chinese medicinal powder feed additive prepared by second step is sent in blender in proportion and is stirred, send in pulverizer subsequently and carry out primary comminution, mixture after pulverizing is sent in super micron mill and carries out separating twice, obtain fine grained, the fine grained after pulverizing to get product feedstuff after sterilization, sealing, pack.
Embodiment 1 decocting liquid 1
By Fructus Gardeniae 55g, Radix Scrophulariae 30g, Radix Paeoniae Rubra 35g, Rhizoma Coptidis 85g, Ramulus Cinnamomi 35g, Rhizoma Osmundae Japonicae 55g, Herba Solani Lyrati 25g, Radix Toddaliae Asiaticae 40g, Concretio Silicea Bambusae 35g, Radix Flemingiae Philippinensis 25g, Caulis et Folium hedyotis hedyotideae 40g, Rhizoma Atractylodis Macrocephalae 50g, Radix Angelicae Sinensis 35g, Flos Lonicerae 70g, Semen Celosiae 25g, Radix Et Caulis Acanthopanacis Senticosi 40g, Herba Abri 30g, Rhizoma Polygoni Cuspidati 45g, Caulis Sargentodoxae 30g, Herba Senecionis Scandentis 20g, Fructus Ligustri Lucidi 30g, Herba Verbenae 25g, Fructus Bruceae 35g, Cacumen Tamaricis 35g, Cortex Moutan 30g, Radix Rubiae 25g, Pericarpium Citri Reticulatae 15g, Rhizoma Polygonati 55g and Radix Glycyrrhizae 25g mixes, three times are decocted with water after pulverizing, add the pure water of 12kg for the first time, second, be the pure water of 10kg for three times, each decoction 1 hour, collecting decoction, filter, concentrated remove portion water, obtain the decocting liquid 1 that crude drug concentration is 1g/ml.
Embodiment 2 decocting liquid 2
By Fructus Gardeniae 53g, Radix Scrophulariae 28g, Radix Paeoniae Rubra 33g, Rhizoma Coptidis 83g, Ramulus Cinnamomi 33g, Rhizoma Osmundae Japonicae 53g, Herba Solani Lyrati 23g, Radix Toddaliae Asiaticae 38g, Concretio Silicea Bambusae 33g, Radix Flemingiae Philippinensis 23g, Caulis et Folium hedyotis hedyotideae 38g, Rhizoma Atractylodis Macrocephalae 48g, Radix Angelicae Sinensis 33g, Flos Lonicerae 68g, Semen Celosiae 23g, Radix Et Caulis Acanthopanacis Senticosi 38g, Herba Abri 28g, Rhizoma Polygoni Cuspidati 43g, Caulis Sargentodoxae 28g, Herba Senecionis Scandentis 18g, Fructus Ligustri Lucidi 32g, Herba Verbenae 27g, Fructus Bruceae 37g, Cacumen Tamaricis 37g, Cortex Moutan 32g, Radix Rubiae 27g, Pericarpium Citri Reticulatae 17g, Rhizoma Polygonati 57g and Radix Glycyrrhizae 27g mixes, three times are decocted with water after pulverizing, add the pure water of 12kg for the first time, second, be the pure water of 10kg for three times, each decoction 1 hour, collecting decoction, filter, concentrated remove portion water, obtain the decocting liquid 2 that crude drug concentration is 1g/ml.
Embodiment 3 decocting liquid 3
By Fructus Gardeniae 57g, Radix Scrophulariae 32g, Radix Paeoniae Rubra 37g, Rhizoma Coptidis 87g, Ramulus Cinnamomi 37g, Rhizoma Osmundae Japonicae 57g, Herba Solani Lyrati 27g, Radix Toddaliae Asiaticae 42g, Concretio Silicea Bambusae 37g, Radix Flemingiae Philippinensis 27g, Caulis et Folium hedyotis hedyotideae 42g, Rhizoma Atractylodis Macrocephalae 52g, Radix Angelicae Sinensis 37g, Flos Lonicerae 72g, Semen Celosiae 27g, Radix Et Caulis Acanthopanacis Senticosi 42g, Herba Abri 32g, Rhizoma Polygoni Cuspidati 47g, Caulis Sargentodoxae 32g, Herba Senecionis Scandentis 22g, Fructus Ligustri Lucidi 28g, Herba Verbenae 23g, Fructus Bruceae 33g, Cacumen Tamaricis 33g, Cortex Moutan 28g, Radix Rubiae 23g, Pericarpium Citri Reticulatae 13g, Rhizoma Polygonati 53g and Radix Glycyrrhizae 23g mixes, three times are decocted with water after pulverizing, add the pure water of 12kg for the first time, second, be the pure water of 10kg for three times, each decoction 1 hour, collecting decoction, filter, concentrated remove portion water, obtain the decocting liquid 3 that crude drug concentration is 1g/ml.
Embodiment 4 Chinese medicinal powder feed additive 1
By Fructus Gardeniae 55g, Radix Scrophulariae 30g, Radix Paeoniae Rubra 35g, Rhizoma Coptidis 85g, Ramulus Cinnamomi 35g, Rhizoma Osmundae Japonicae 55g, Herba Solani Lyrati 25g, Radix Toddaliae Asiaticae 40g, Concretio Silicea Bambusae 35g, Radix Flemingiae Philippinensis 25g, Caulis et Folium hedyotis hedyotideae 40g, Rhizoma Atractylodis Macrocephalae 50g, Radix Angelicae Sinensis 35g, Flos Lonicerae 70g, Semen Celosiae 25g, Radix Et Caulis Acanthopanacis Senticosi 40g, Herba Abri 30g, Rhizoma Polygoni Cuspidati 45g, Caulis Sargentodoxae 30g, Herba Senecionis Scandentis 20g, Fructus Ligustri Lucidi 30g, Herba Verbenae 25g, Fructus Bruceae 35g, Cacumen Tamaricis 35g, Cortex Moutan 30g, Radix Rubiae 25g, Pericarpium Citri Reticulatae 15g, Rhizoma Polygonati 55g and Radix Glycyrrhizae 25g mixes, the pure water of 12kg is added after pulverizing, after jolting mixing, soak 40min, connect reflux condensing tube, be heated to boiling, and keep 100 DEG C micro-ly to boil 2 hours, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the first filtrate, filtering residue adds the pure water of 10kg again, after jolting mixing, soak 40min, connect reflux condensing tube, be heated to 100 DEG C of boilings, and keep 1 hour, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, when being evaporated to 70 DEG C, relative density is the clear paste of 1.15, be cooled to room temperature, add determining alcohol be 80% ethanol make alcohol content reach 80wt%, stir evenly, leave standstill and be no less than 12h, filter precipitation, during supernatant recovery ethanol to 70 DEG C, relative density is the clear paste of 1.25, use 10L cyclohexane extraction, 10L ethyl acetate, 5L n-butyl alcohol extracts it successively, and reclaim under reduced pressure wherein organic solvent, obtain and get dry extract, be ground into powder, dry, obtain Chinese medicinal powder feed additive 1.
Embodiment 5 feedstuff 1
By 6.5kg Semen Maydis and the mixing of 2kg bean cake, the water adding 4kg stirs, be heated to 70 DEG C, be sprinkled into 200g Sal, after cooling, load in container, put into 30cm depths, underground, said mixture layering loads in container, compacting layer by layer, until 20 centimetres above ground level, plastic covering film phonograph seal, ferment 6 days, obtain fermentation product, by 400g calcium carbonate, 300g calcium hydrogen phosphate, 400g vitamin mixtures additive LV62, 200g composite additive of trace elements M-P, methionine 200g, threonine 100g and the fermentation product prepared above, Chinese medicinal powder feed additive 1 prepared by 1.2kg embodiment 4 is sent in blender and is stirred, send in pulverizer subsequently and carry out primary comminution, mixture after pulverizing is sent in super micron mill and carries out separating twice, obtain fine grained, fine grained after pulverizing is through sterilization, sealing, get product after pack feedstuff 1.
Embodiment 6 Chinese medicinal powder feed additive 2
By Fructus Gardeniae 50g, Radix Scrophulariae 25g, Radix Paeoniae Rubra 30g, Rhizoma Coptidis 80g, Ramulus Cinnamomi 30g, Rhizoma Osmundae Japonicae 50g, Herba Solani Lyrati 20g, Radix Toddaliae Asiaticae 35g, Concretio Silicea Bambusae 30g, Radix Flemingiae Philippinensis 20g, Caulis et Folium hedyotis hedyotideae 35g, Rhizoma Atractylodis Macrocephalae 45g, Radix Angelicae Sinensis 30g, Flos Lonicerae 65g, Semen Celosiae 20g, Radix Et Caulis Acanthopanacis Senticosi 35g, Herba Abri 25g, Rhizoma Polygoni Cuspidati 40g, Caulis Sargentodoxae 25g, Herba Senecionis Scandentis 15g, Fructus Ligustri Lucidi 25g, Herba Verbenae 20g, Fructus Bruceae 30g, Cacumen Tamaricis 30g, Cortex Moutan 25g, Radix Rubiae 20g, Pericarpium Citri Reticulatae 10g, Rhizoma Polygonati 50g and Radix Glycyrrhizae 20g mixes, the pure water of 10kg is added after pulverizing, after jolting mixing, soak 40min, connect reflux condensing tube, be heated to boiling, and keep 100 DEG C micro-ly to boil 2 hours, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the first filtrate, filtering residue adds the pure water of 9kg again, after jolting mixing, soak 40min, connect reflux condensing tube, be heated to 100 DEG C of boilings, and keep 1 hour, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, when being evaporated to 70 DEG C, relative density is the clear paste of 1.15, be cooled to room temperature, add determining alcohol be 80% ethanol make alcohol content reach 80wt%, stir evenly, leave standstill and be no less than 12h, filter precipitation, during supernatant recovery ethanol to 70 DEG C, relative density is the clear paste of 1.25, use 10L cyclohexane extraction, 10L ethyl acetate, 5L n-butyl alcohol extracts it successively, and reclaim under reduced pressure wherein organic solvent, obtain and get dry extract, be ground into powder, dry, obtain Chinese medicinal powder feed additive 2.
Embodiment 7 Chinese medicinal powder feed additive 3
By Fructus Gardeniae 65g, Radix Scrophulariae 40g, Radix Paeoniae Rubra 45g, Rhizoma Coptidis 95g, Ramulus Cinnamomi 45g, Rhizoma Osmundae Japonicae 65g, Herba Solani Lyrati 35g, Radix Toddaliae Asiaticae 50g, Concretio Silicea Bambusae 45g, Radix Flemingiae Philippinensis 35g, Caulis et Folium hedyotis hedyotideae 50g, Rhizoma Atractylodis Macrocephalae 60g, Radix Angelicae Sinensis 45g, Flos Lonicerae 80g, Semen Celosiae 35g, Radix Et Caulis Acanthopanacis Senticosi 50g, Herba Abri 40g, Rhizoma Polygoni Cuspidati 55g, Caulis Sargentodoxae 40g, Herba Senecionis Scandentis 30g, Fructus Ligustri Lucidi 40g, Herba Verbenae 35g, Fructus Bruceae 45g, Cacumen Tamaricis 45g, Cortex Moutan 40g, Radix Rubiae 35g, Pericarpium Citri Reticulatae 25g, Rhizoma Polygonati 65g and Radix Glycyrrhizae 35g mixes, the pure water of 13kg is added after pulverizing, after jolting mixing, soak 40min, connect reflux condensing tube, be heated to boiling, and keep 100 DEG C micro-ly to boil 2 hours, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the first filtrate, filtering residue adds the pure water of 11kg again, after jolting mixing, soak 40min, connect reflux condensing tube, be heated to 100 DEG C of boilings, and keep 1 hour, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, when being evaporated to 70 DEG C, relative density is the clear paste of 1.15, be cooled to room temperature, add determining alcohol be 80% ethanol make alcohol content reach 80wt%, stir evenly, leave standstill and be no less than 12h, filter precipitation, during supernatant recovery ethanol to 70 DEG C, relative density is the clear paste of 1.25, use 10L cyclohexane extraction, 10L ethyl acetate, 5L n-butyl alcohol extracts it successively, and reclaim under reduced pressure wherein organic solvent, obtain and get dry extract, be ground into powder, dry, obtain Chinese medicinal powder feed additive 3.
Embodiment 8 Viral Assay
8.1 material
Strain: test riemerella anatipestifer is given by Shandong Agricultural University's veterinary college.
Medicine: decocting liquid 1 prepared by the embodiment of the present invention 1.
The separation of cause of disease: asepticly take die of illness Sanguis Anas domestica, liver, blood agar plate is rule, and candle jar method cultivates 24h, observes bacterial growth characteristic.By colonies typical, streak inoculation is dull and stereotyped in blood agar plate, tryptic soy agar flat board (TSA), maconkey agar flat board and plain agar respectively, every strain bacterium inoculates two flat boards, a dull and stereotyped candle jar method is cultivated, and another is directly put into 37 DEG C of calorstats and cultivates.Observe colonial morphology after 48h and microscopy, the suspicious bacterium colony of picking preserves qualification after purification on tryptic soy agar flat board.
Bacterial culture and count: the riemerella anatipestifer through qualification is inoculated in TSA flat board, 1 ~ 2 colony inoculation is got in tryptic soy broth medium after cultivation, be placed on 200r/min, 24h is cultivated in (36.9 ± 0.1) DEG C constant-temperature table, then bacterium liquid sample is got, survey its OD600 value, be adjusted to about 0.15, 10 times of serial dilutions are carried out again with sterile saline, getting 100 μ L dilution bacterium liquid is added on TSA flat board, even with the coating of aseptic glass rake, and horizontal rest 10min, each dilution factor does 3 repetitions, observe counting cultivate 18 ~ 24h in 37 DEG C of candle cylinders after and (control bacterial population 10
8individual/mL).
Odontothrips loti drug sensitivity test: drawing with liquid-transfering gun the concentration prepared is 10
8cfu/mL(OD600=0.15) bacteria suspension 500 μ L, on tryptic soy agar flat board, even with the coating of aseptic glass rake, horizontal rest 10min, then clamps aseptic Oxford cup with aseptic nipper, is placed on gently equably on flat board.Draw in above-mentioned traditional Chinese medicine decoction 1 to the Oxford cup prepared of 100 μ L, candle jar method cultivates 24h, measures and records inhibition zone size (mm).It is drug resistance that antibacterial circle diameter is less than 10mm; 10 ~ 15mm is less sensitive; 16 ~ 20mm is medium sensitivity; More than 20mm is extremely sensitive.
Result of the test:
Drug sensitivity test result
The decocting liquid 1 pair of riemerella anatipestifer adopting the embodiment of the present invention 1 to prepare is antibacterial circle diameter is 40.0mm, is high sensitive.
Embodiment 9 Animal experiment
Animal data: in JIUYUE, 2011, in succession there is epidemic situation in adjacent duck factory of two, Linyi county, two groups of ducks are the newly-hatched duckling of buying on the same day, in 20 age in days left and right phase secondary diseases, ill duck totally 1271, sick duck show as spirit depressed, suffer from diarrhoea, wave on foot, the symptom such as head and neck trembles, once the unsatisfactory curative effect such as penicillin, amoxicillin was used, 100 in heaven of 3 day time, through Clinical anatomic, tentative diagnosis is that infectious serositis in duck infects.
Clinical symptoms and case change
Ill duck fundamental symptoms of institute is consistent: normal sudden onset, in earlier stage lassitude, appetite is bad, eye, nose flows out a small amount of serosity secretions, moistening near the eyes, arrange yellow green or white water sample loose stool subsequently, be reluctant to walk or ataxia, both feet paralysis, head and neck trembles, lose weight, some nasal sinuses swelling, dyspnea, some arthroncuss, last exhaustion is dead, the course of disease 1 ~ 3 day, dissect and mainly see: pericardial effusion, be mixed with fibroid floccule, epicardial surface is coarse, serious pericardium and thoracic wall stick together, liver surface covers one deck translucent or opaque lark fibroid pseudomembrane, very easily peel off, liver becomes yellowish red color or khaki, gollbladder dilation, balloon membranes is muddy or thicken, spleen enlargement is mottling, there is the orange-yellow clear liquid of volume in abdominal cavity, according to incidence, clinical symptoms and pathological change are diagnosed as infectious serositis in duck.
Therapeutic Method
1171 ducks of survival are divided into 4 groups, first group adopts the former treated powder of enrofloxacin, adds in drinking water, for the free diet of duck according to 10g/100kg, second group of decocting liquid 1 adopting the embodiment of the present invention 1 to prepare, every day gavages 30ml, and the 3rd group of feedstuff 1 adopting the embodiment of the present invention 5 to prepare, for duck free choice feeding, 4th group only adopts conventional feeds method feeding, do not add any medicine, each group is raised 5 days continuously, observed result.
Criterion
In medication 5 days, cardinal symptom disappears or is obviously improved as effectively, is invalidly not improved for sings and symptoms.
The results are shown in Table 1.
Table 1 medicine is to the therapeutic effect of infectious serositis in duck
| Group | Treatment number (only) | Significant figure (only) | Effective percentage (%) | Death toll (only) | Mortality rate (%) |
| First group | 300 | 257 | 85.7 | 43 | 14.3 |
| Second group | 300 | 292 | 97.3 | 8 | 2.7 |
| 3rd group | 300 | 288 | 96 | 12 | 4 |
| 4th group | 271 | 0 | 0 | 247 | 91.1 |
As can be seen from Table 1, Chinese medicine of the present invention is adopted to have significant curative effect to infectious serositis in duck.
Fructus Gardeniae: bitter in the mouth, cold in nature, enter the heart, lung, three burnt, have the effect of relieving restlessness pathogenic fire purging, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, be mainly used in the vexed uneasiness of epidemic febrile disease heat stagnation breast gastral cavity, bother not peaceful; Stagnation of liver-QI is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, conjunctival congestion dry pharynx; Jaundice due to damp-heat; The symptoms such as the abdominal distention of qi depression to blood stasis.
Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel, have clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing supports effect of kidney, cure mainly pathogenic warmth to join the army, cave in pericardium, maculae caused by violent heat pathogen, and consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin hinder the cards such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Radix Paeoniae Rubra: bitter in the mouth, micro-hardship, returns Liver Channel, has removing fire from the liver, clearing away heat and cooling blood, effect of stasis-dispelling and pain-killing, cure mainly the conjunctival congestion and swelling pain of high liver fire, have a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, and macule is hemorrhage, and blood stasis amenorrhea; The haematemesis hematuria of the absurd row of burning hot flourishing forcing blood; The trip of women's heat in blood is through too much; Various pain caused by blood retardance; The cards such as the furuncle carbuncle of heat in blood poison Sheng.
Rhizoma Coptidis: bitter in the mouth, cold in nature, enters the heart, lung, gallbladder, stomach, large intestine channel, has the effect of heat clearing and damp drying, eliminating fire and detoxication, cooling blood for improving eyesight, be longer than the fire of removing pathogen in the heart stomach, have preventing or arresting vomiting concurrently to disappear the merit of painful abdominal mass, can be used for the prosperous caused dysphoria and insomnia for the treatment of heart-fire, and the high fever coma of epidemic febrile disease, vexed, thirsty; Also can be used for damp and hot caused dysentery, tenesmus; The cards such as pyretic toxicity carbuncle sore, eczema, aphtha of the mouth and tongue, epidemic hemorrhagic conjunctivitis, the effect that Rhizoma Coptidis has function of gallbladder promoting, expansion thin vessels, reduces blood pressure, and can leukocytic phagocytic activity be strengthened, there is stronger bacteriostasis to staphylococcus aureus, Hemolytic streptococcus, streptococcus pneumoniae, meningococcus, vibrio cholera, anthrax bacillus, dysentery bacterium.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel, have diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effect of dispersing cold for relieving pain, Ramulus Cinnamomi warming the meridian and promoting blood circulation, horizontal logical podomere, for affection of exogenous wind-cold exterior syndrome, no matter have antiperspirant, losslessly all can to apply, also for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea, rheumatic arthralgia, the cards such as shoulder arm podomere cold type of pain, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, cough with dyspnea dizziness waits phlegm retention syndrome.
Rhizoma Osmundae Japonicae: bitter in the mouth, cold nature, returns spleen, and stomach warp, has heat-clearing and toxic substances removing, hemostasis by removing blood stasis, and effect of parasite killing, for influenza; Epidemic encephalitis; Encephalitis b parotitis; Carbuncle pyogenic infections from tumour or sore; Measles; Chickenpox; Dysentery; Spit blood; Epistaxis; Have blood in stool; Metrorrhagia; Leukorrhagia; Pinworm; The cards such as cestode.
Herba Solani Lyrati: latin name Solanum lyratumThunb, bitter in the mouth, property is put down, and have clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, anticancer effect, cures mainly cold, fever, icterohepatitis, cholecystitis, cholelithiasis, cancer, uterine erosion, leucorrhea, oedema due to nephritis; External is controlled carbuncle furuncle and phyma poison and is waited card.
Radix Toddaliae Asiaticae: latin name Radix Toddaliae Asiaticae, acrid in the mouth, micro-hardship, warm in nature, there is dissipating blood stasis hemostasis, expelling wind and removing dampness, effect of subduing swelling and detoxicating, cure mainly rheumatalgia, stomachache, traumatic injury, spit blood, epistaxis, sub-official is hemorrhage, knife injury is hemorrhage, amenorrhea, dysmenorrhea, intercostal neuralgia, the cards such as furuncle toxic swelling.
Concretio Silicea Bambusae: sweet in the mouth, cold in nature, have clear heat and eliminate phlegm, effect of cool heart arresting convulsion, cures mainly calentura coma delirium, and middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.The cards such as phlegm-heat cough.
Radix Flemingiae Philippinensis: sweet in the mouth, slightly warm in nature, flat, return lung, kidney, urinary bladder channel, have expelling wind and removing dampness, effect of repercussive removing toxic substances, cures mainly rheumatic arthralgia, chronic nephritis, traumatic injury, carbuncle, the cards such as throat moth.
Caulis et Folium hedyotis hedyotideae: latin name Argyreia pierreana, sweet in the mouth, light, cool in nature, there is clearing away summer-heat, wind-damp dispelling, effect of reuniting the fractured tendons and bones.Cure mainly heatstroke, cold cough, gastroenteritis, rheumatic arthritis, traumatic injury, fracture, skin eczema.
The Rhizoma Atractylodis Macrocephalae: latin name Attractylodis Macrocephalae Rhizoma, sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, there is spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cures mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, has regulating action to gastrointestinal function.
Radix Angelicae Sinensis: sweet in the mouth, pungent, warm in nature, enters liver, the heart, spleen channel, enriches blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation, be mainly used in having a dizzy spell of deficiency of heart-blood, fatigue and weakness, shortness of breath and palpitation, and other syndrome of deficiency of blood; The sea of blood is hollow, the menoxenia of the cold and deficiency of CHONG and REN meridians or congestion retardance, dysmenorrhoea, produces or suffers from abdominal pain, and other blood stasis are had a pain and the symptom such as the constipation of deficiency of YIN insufficiency of blood dryness of the intestine.
Flos Lonicerae: sweet in the mouth, cold in nature, enters the heart, lung, stomach, large intestine channel, has the effect of heat-clearing and toxic substances removing, and holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is comparatively contained, or when epidemic febrile disease is still not descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of pathogenic heat; Pyretic toxicity dysentery, stool hematochezia; Fever disease in summer is demonstrate,proved; The carbuncle sore that pyretic toxicity gathers is from the beginning of the, inflammation heat person of swelling and ache etc., Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, can leukocytic phagocytic function be promoted, have stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, tubercule bacillus etc., the pyretic toxicity that Flos Lonicerae is divided QI and blood battalion is all effective, and has broad-spectrum antibacterial action.
Semen Celosiae: bitter in the mouth, cold nature, returns Liver Channel, has purging liver-fire, effect of improving acuity of vision and removing nebula, cures mainly liver-heat conjunctival congestion, the raw nebula film of order, blurring of vision, the cards such as dizziness due to liver-fire.
Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature, enters spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.
Herba Abri: sweet in the mouth, hardship, cool in nature, GUIXIN; Lung; Liver; Stomach; Kidney channel, has clearing away heat-damp and promoting diuresis, effect of eliminating stasis to stop pain, main treatment icterohepatitis, stomachache, rheumatic ostalgia, traumatic injury stasis of blood pain, the cards such as mastalgia.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, enters liver, gallbladder, lung meridian, has expelling wind and removing dampness, dissipating blood stasis analgesic therapy, the effect of preventing phlegm from forming and stopping coughing, for rheumatic arthralgia, jaundice due to damp-heat, dysentery, stranguria with turbid discharge leukorrhagia, blood stasis amenorrhea, traumatic injury, the cards such as cough due to lung-heat's abundant expectoration.
Caulis Sargentodoxae: bitter in the mouth, property is put down, and returns liver, large intestine channel, has the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cure mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.
Herba Senecionis Scandentis: latin name Senecionis Scandentis Hebra, cold in nature, bitter in the mouth, returns lung, Liver Channel, has effect of heat-clearing and toxic substances removing, improving eyesight dampness removing, has the cards such as carbuncle sore tumefacting virus, cold, fever, conjunctival congestion and swelling pain, dysentery, skin eczema.
Fructus Ligustri Lucidi: sweet in the mouth, hardship, be slightly cold, enters liver, kidney channel, has strong liver kidney tonifying, the effect of clearing away heat to improve acuity of vision, is mainly used in treating hepatic and renal YIN deficiency, and the head loses foster dizzy tinnitus, the symptoms such as yin asthenia generating intrinsic heat.Fructus Ligustri Lucidi can promote leukocyte, strengthens effect of immunologic function, has stronger inhibitory action to staphylococcus aureus, dysentery bacterium.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods, has heart tonifying, diuresis and hepatoprotective effect, the leukopenia quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, escherichia coli.
Herba Verbenae: latin name Verbenae Herba, bitter in the mouth, cool in nature, return liver, spleen channel, have promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, effect of inducing diuresis to remove edema, cures mainly the cards such as lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria.
Fructus Bruceae: latin name Bruceae Fructus, bitter in the mouth, cold in nature, return large intestine channel, Liver Channel, have heat-clearing and toxic substances removing, dysentery relieving, preventing the attack (or recurrence) of malaria, effect of corrosion wart, cures mainly dysentery, malaria; The cards such as external treatment wart, clavus.
Cacumen Tamaricis: latin name Cacumen Tamaricis, property is put down, sweet in the mouth, pungent, enters the heart, lung, stomach warp, has loose wind, and removing toxic substances, delivers effect of rash, cure mainly measles without adequate eruption, the cards such as rheumatic arthralgia.
Cortex Moutan: latin name Moutan Cortex, bitter in the mouth, pungent, cold nature, enters the heart, liver, kidney channel, has the effect of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, for the card such as fever due to yin deficiency, the acute appendicitis of damp and hot knot poison, depressed blood stasis, xerostomia, deep red tongue of excessive noxious heat; And liver-fire conjunctival congestion and swelling pain, stomach-fire gingiva pain.
Radix Rubiae: cold in nature, bitter in the mouth, returns Liver Channel, effect: cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling, cards such as curing mainly heat in blood spitting of blood, haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia, jaundice, carbuncle sore, hemorrhoid are swollen.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, spleen lung can be entered, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gather around stagnant, chest and diaphragm feeling of fullness and the disease such as stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the card such as abundant expectoration cough.
Rhizoma Polygonati: sweet in the mouth, property is put down, and enters lung, spleen, kidney channel, has enriching qi and yin, spleen invigorating lung moistening, the effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
Radix Glycyrrhizae: sweet in the mouth, property put down, enter 12 warps, have heat-clearing and toxic substances removing, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. be used for the treatment of a Chinese medicine for infectious serositis in duck, it is characterized in that: the crude drug of described Chinese medicine is only made up of Fructus Gardeniae, Radix Scrophulariae, Radix Paeoniae Rubra, Rhizoma Coptidis, Ramulus Cinnamomi, Rhizoma Osmundae Japonicae, Herba Solani Lyrati, Radix Toddaliae Asiaticae, Concretio Silicea Bambusae, Radix Flemingiae Philippinensis, Caulis et Folium hedyotis hedyotideae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Flos Lonicerae, Semen Celosiae, Radix Et Caulis Acanthopanacis Senticosi, Herba Abri, Rhizoma Polygoni Cuspidati, Caulis Sargentodoxae, Herba Senecionis Scandentis, Fructus Ligustri Lucidi, Herba Verbenae, Fructus Bruceae, Cacumen Tamaricis, Cortex Moutan, Radix Rubiae, Pericarpium Citri Reticulatae, Rhizoma Polygonati and Radix Glycyrrhizae;
In described Chinese medicine, the weight portion of each crude drug is respectively Fructus Gardeniae 50 weight portion ~ 60 weight portion, Radix Scrophulariae 25 weight portion ~ 35 weight portion, Radix Paeoniae Rubra 30 weight portion ~ 40 weight portion, Rhizoma Coptidis 80 weight portion ~ 90 weight portion, Ramulus Cinnamomi 30 weight portion ~ 40 weight portion, Rhizoma Osmundae Japonicae 50 weight portion ~ 60 weight portion, Herba Solani Lyrati 20 weight portion ~ 30 weight portion, Radix Toddaliae Asiaticae 35 weight portion ~ 45 weight portion, Concretio Silicea Bambusae 30 weight portion ~ 40 weight portion, Radix Flemingiae Philippinensis 20 weight portion ~ 30 weight portion, Caulis et Folium hedyotis hedyotideae 35 weight portion ~ 45 weight portion, the Rhizoma Atractylodis Macrocephalae 45 weight portion ~ 55 weight portion, Radix Angelicae Sinensis 30 weight portion ~ 40 weight portion, Flos Lonicerae 65 weight portion ~ 75 weight portion, Semen Celosiae 20 weight portion ~ 30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion ~ 45 weight portion, Herba Abri 25 weight portion ~ 35 weight portion, Rhizoma Polygoni Cuspidati 40 weight portion ~ 50 weight portion, Caulis Sargentodoxae 25 weight portion ~ 35 weight portion, Herba Senecionis Scandentis 15 weight portion ~ 25 weight portion, Fructus Ligustri Lucidi 25 weight portion ~ 35 weight portion, Herba Verbenae 20 weight portion ~ 30 weight portion, Fructus Bruceae 30 weight portion ~ 40 weight portion, Cacumen Tamaricis 30 weight portion ~ 40 weight portion, Cortex Moutan 25 weight portion ~ 35 weight portion, Radix Rubiae 20 weight portion ~ 30 weight portion, Pericarpium Citri Reticulatae 10 weight portion ~ 20 weight portion, Rhizoma Polygonati 50 weight portion ~ 60 weight portion and Radix Glycyrrhizae 20 weight portion ~ 30 weight portion.
2. Chinese medicine as claimed in claim 1, is characterized in that: in described Chinese medicine, the weight portion of each crude drug is respectively Fructus Gardeniae 53 weight portion ~ 57 weight portion, Radix Scrophulariae 28 weight portion ~ 32 weight portion, Radix Paeoniae Rubra 33 weight portion ~ 37 weight portion, Rhizoma Coptidis 83 weight portion ~ 87 weight portion, Ramulus Cinnamomi 33 weight portion ~ 37 weight portion, Rhizoma Osmundae Japonicae 53 weight portion ~ 57 weight portion, Herba Solani Lyrati 23 weight portion ~ 27 weight portion, Radix Toddaliae Asiaticae 38 weight portion ~ 42 weight portion, Concretio Silicea Bambusae 33 weight portion ~ 37 weight portion, Radix Flemingiae Philippinensis 23 weight portion ~ 27 weight portion, Caulis et Folium hedyotis hedyotideae 38 weight portion ~ 42 weight portion, the Rhizoma Atractylodis Macrocephalae 48 weight portion ~ 52 weight portion, Radix Angelicae Sinensis 33 weight portion ~ 37 weight portion, Flos Lonicerae 68 weight portion ~ 72 weight portion, Semen Celosiae 23 weight portion ~ 27 weight portion, Radix Et Caulis Acanthopanacis Senticosi 38 weight portion ~ 42 weight portion, Herba Abri 28 weight portion ~ 32 weight portion, Rhizoma Polygoni Cuspidati 43 weight portion ~ 47 weight portion, Caulis Sargentodoxae 28 weight portion ~ 32 weight portion, Herba Senecionis Scandentis 18 weight portion ~ 22 weight portion, Fructus Ligustri Lucidi 28 weight portion ~ 32 weight portion, Herba Verbenae 23 weight portion ~ 27 weight portion, Fructus Bruceae 33 weight portion ~ 37 weight portion, Cacumen Tamaricis 33 weight portion ~ 37 weight portion, Cortex Moutan 28 weight portion ~ 32 weight portion, Radix Rubiae 23 weight portion ~ 27 weight portion, Pericarpium Citri Reticulatae 13 weight portion ~ 17 weight portion, Rhizoma Polygonati 53 weight portion ~ 57 weight portion and Radix Glycyrrhizae 23 weight portion ~ 27 weight portion.
3. Chinese medicine as claimed in claim 1, it is characterized in that: in described Chinese medicine, the weight portion of each crude drug is respectively Fructus Gardeniae 55 weight portion, Radix Scrophulariae 30 weight portion, Radix Paeoniae Rubra 35 weight portion, Rhizoma Coptidis 85 weight portion, Ramulus Cinnamomi 35 weight portion, Rhizoma Osmundae Japonicae 55 weight portion, Herba Solani Lyrati 25 weight portion, Radix Toddaliae Asiaticae 40 weight portion, Concretio Silicea Bambusae 35 weight portion, Radix Flemingiae Philippinensis 25 weight portion, Caulis et Folium hedyotis hedyotideae 40 weight portion, the Rhizoma Atractylodis Macrocephalae 50 weight portion, Radix Angelicae Sinensis 35 weight portion, Flos Lonicerae 70 weight portion, Semen Celosiae 25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 40 weight portion, Herba Abri 30 weight portion, Rhizoma Polygoni Cuspidati 45 weight portion, Caulis Sargentodoxae 30 weight portion, Herba Senecionis Scandentis 20 weight portion, Fructus Ligustri Lucidi 30 weight portion, Herba Verbenae 25 weight portion, Fructus Bruceae 35 weight portion, Cacumen Tamaricis 35 weight portion, Cortex Moutan 30 weight portion, Radix Rubiae 25 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Rhizoma Polygonati 55 weight portion and Radix Glycyrrhizae 25 weight portion.
4. the preparation method of Chinese medicine described in claim 1, it is characterized in that: described Chinese drug preparation becomes decocting liquid, it is specially and described component is mixed in proportion, and decocts with water three times after pulverizing, and first time adds the pure water relative to raw medicinal material quality 10 ~ 12 times amount, second and third time is the pure water of 8 ~ 10 times amount, each decoction 1 hour, collecting decoction, filters, concentrated remove portion water, obtaining crude drug concentration is the decocting liquid of 1g/ml ~ 2g/ml.
5. the preparation method of Chinese medicine described in claim 1, it is characterized in that: described Chinese drug preparation becomes Chinese medicinal powder feed additive, it is specially and described component is mixed in proportion, the pure water relative to raw medicinal material quality 10 ~ 12 times amount is added after pulverizing, after jolting mixing, soak 30 ~ 40min, connect reflux condensing tube, be heated to boiling, and keep 100 DEG C micro-ly to boil 2 hours, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the first filtrate, filtering residue adds relative to raw medicinal material quality 8 ~ 10 times of quality pure water again, after jolting mixing, soak 30min ~ 40min, connect reflux condensing tube, be heated to 100 DEG C of boilings, and keep 1 hour, stop heating, be cooled to room temperature, to wherein pour out by medical filtration, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, when being evaporated to 70 DEG C, relative density is the clear paste of 1.10 ~ 1.15, be cooled to room temperature, add determining alcohol be 70% ~ 80% ethanol make alcohol content reach 70 ~ 80wt%, stir evenly, leave standstill and be no less than 12h, filter precipitation, during supernatant recovery ethanol to 70 DEG C, relative density is the clear paste of 1.20 ~ 1.25, use cyclohexane extraction, ethyl acetate, n-butyl alcohol extracts it successively, and reclaim under reduced pressure wherein organic solvent, obtain and get dry extract, be ground into powder, dry, obtain Chinese medicinal powder feed additive.
6. one kind is used for the treatment of the feedstuff of infectious serositis in duck, it is characterized in that, comprising: Semen Maydis, bean cake, Sal, calcium carbonate, calcium hydrogen phosphate, vitamin mixtures additive, trace mineral supplement, ispol additive and the Chinese medicine according to claim 1 as fodder additive.
7. feedstuff as claimed in claim 6, is characterized in that: in described feedstuff, the weight portion of each component is Semen Maydis 60 ~ 70 weight portion, bean cake 15 ~ 25 weight portion, Sal 1 ~ 3 weight portion, calcium carbonate 3 ~ 6 weight portion, calcium hydrogen phosphate 2 ~ 4 weight portion, vitamin mixtures additive 2 ~ 4 weight portion, trace mineral supplement 1 ~ 3 weight portion, ispol additive 2 ~ 4 weight portion and Chinese medicine according to claim 1 10 ~ 14 weight portion as fodder additive.
8. the preparation method of feedstuff described in claim 6 or 7, is characterized in that: be specially,
The first step, is mixed in proportion Semen Maydis and bean cake, and the water adding 1/3 ~ 1/2 of the mixture quality formed relative to Semen Maydis and bean cake stirs, be heated to 60 ~ 100 DEG C, be sprinkled into Sal in proportion, after cooling, load in container, put into 20 ~ 30cm depths, underground, said mixture layering loads in container, compacting layer by layer, until 10 ~ 25 centimetres above ground level, plastic covering film phonograph seal, ferments 4 ~ 8 days, obtains fermentation product;
Second step, prepares Chinese medicinal powder feed additive according to method described in claim 5;
3rd step, by fermentation product prepared by calcium carbonate, calcium hydrogen phosphate, vitamin mixtures additive, trace mineral supplement, ispol additive and the first step, Chinese medicinal powder feed additive prepared by second step is sent in blender in proportion and is stirred, send in pulverizer subsequently and carry out primary comminution, mixture after pulverizing is sent in super micron mill and carries out separating twice, obtain fine grained, the fine grained after pulverizing to get product feedstuff after sterilization, sealing, pack.
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| CN103859156B (en) * | 2014-04-01 | 2015-03-25 | 山东新希望六和集团有限公司 | Feed for controlling duck pulp conjunctivitis, Chinese medicine composition and preparation method |
| CN104431607A (en) * | 2014-12-22 | 2015-03-25 | 郝智慧 | Feed capable of preventing and treating infectious serositis of duck |
| CN104435468A (en) * | 2014-12-22 | 2015-03-25 | 郝智慧 | Traditional Chinese medicine powder for preventing and controlling infectious serositis of ducks |
| CN105055586B (en) * | 2015-08-11 | 2018-10-23 | 河南科技大学 | A kind of Chinese medicine preparation of prevention kind duck infectious serositis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101297882A (en) * | 2007-10-25 | 2008-11-05 | 天津生机集团有限公司 | Chinese medicine preparation for treating infectious serositis of duck and preparation method thereof |
| CN101314026A (en) * | 2008-06-27 | 2008-12-03 | 雷清莲 | Serositis in duckling vaccine oral liquid synergistic agent for poultry biology and preparation method thereof |
| CN101475639A (en) * | 2008-08-19 | 2009-07-08 | 福州大北农生物技术有限公司 | Mixed yolk antibody for preventing and treating duck infectious serositis and preparation thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101297882A (en) * | 2007-10-25 | 2008-11-05 | 天津生机集团有限公司 | Chinese medicine preparation for treating infectious serositis of duck and preparation method thereof |
| CN101314026A (en) * | 2008-06-27 | 2008-12-03 | 雷清莲 | Serositis in duckling vaccine oral liquid synergistic agent for poultry biology and preparation method thereof |
| CN101475639A (en) * | 2008-08-19 | 2009-07-08 | 福州大北农生物技术有限公司 | Mixed yolk antibody for preventing and treating duck infectious serositis and preparation thereof |
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