CN102641366A - Traditional Chinese medicine composition for preventing and treating proventriculitis and gizzard erosion of poultry - Google Patents
Traditional Chinese medicine composition for preventing and treating proventriculitis and gizzard erosion of poultry Download PDFInfo
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- CN102641366A CN102641366A CN2012101553436A CN201210155343A CN102641366A CN 102641366 A CN102641366 A CN 102641366A CN 2012101553436 A CN2012101553436 A CN 2012101553436A CN 201210155343 A CN201210155343 A CN 201210155343A CN 102641366 A CN102641366 A CN 102641366A
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Abstract
The invention relates to a traditional Chinese medicine composition for preventing and treating proventriculitis and gizzard erosion of poultry. The traditional Chinese medicine takes swordlike atractylodes rhizome with the effects of eliminating dampness, invigorating spleen, expelling wind and dispelling cold as a monarch, membranous milkvetch root with the effects of tonifying qi, consolidating exterior, supporting sores and growing muscles as a minister, Indian buead with the effects of inducing diuresis, eliminating dampness, invigorating spleen and calming heart and tangerine peel with the effects of regulating qi and invigorating spleen as assistants, and liquorice root with the effects of reinforcing spleen and tonifying qi for coordinating all the medicines and is further suitable for prevention and treatment requirements of the proventriculitis and the gizzard erosion in different pathogenesis stages. The traditional Chinese medicine composition has the characteristics of invigorating spleen, nourishing stomach and treating both manifestation and root causes of diseases, and a large number of clinical applications for treating the diseases of the poultry show that the traditional Chinese medicine composition has the advantages of exact effects, no toxic or side effects, no residue of the medicines and the like.
Description
Technical field
The invention belongs to veterinary drug preparation production and application, relate to a kind of Chinese prescription, especially relate to a kind of Chinese medicine composition of preventing and treating poultry proventriculitis gizzard erosion.
Background technology
In recent years, the most of commercial meat bird of China culture the compact district popular gradually a kind of be the disease of principal character with proventriculitis, gizzard erosion.Morbidity chicken all living creatures is long to be obstructed, the chicken body weight is uneven, and feed intake is low, becomes thin, depleted dead, cut open the inspection symptom mainly show as glandular stomach swelling, muscular stomach cutin membrane downright bad, come off intestinal swelling, Catarrhal or hemorrhagic inflammation.This sick cause of disease is complicated, with ambient humidity, feed mould, virus, antibacterial etc. relation is arranged all.Because the complexity of the cause of disease, general antibiotic, antiviral treatment are difficult to receive produce effects, and between the death rate 10-50%, other the infecteds of secondary even full crowd eliminate.
Chinese veterinarian's theory thinks, this disease belongs to dysfunction of the spleen in transportation, the taste card of becoming estranged.The poultry internal organs are tender and lovely, and hedge is loose, and yin and yang 2 Qi is all more childish and tender; Lung, spleen, kidney three dirty deficiencies, it is weak to defend outer function, poor to the resistance of exopathogen.Spleen is lunar wet soil, and state placed in the middle and main fortuneization receive water paddy with stomach is same, and defeated cloth is precise and tiny.The dry evil of its property happiness is wet, and in damp and hot season, poultry very easily dysfunction of the spleen in transportation occurs, taste are become estranged.Damp is stranded in middle Jiao, and spleen fortune is unstrong, and mechanism of qi is obstructed, and damp perfusion the intestines and stomach causes glandular stomach, muscular stomach, intestinal ulcer, inflammation for a long time.
To the control of proventriculitis, gizzard erosion,, the on probation of some Chinese traditional patent formulations also arranged, but still has following problem at present though reported that some are antibiotic, the antiviral comprehensive therapeutic plan:
1. owing to the complexity of this disease cause of disease, antibiotic, antiviral therapy often is difficult to obtain produce effects, and has increased the risk of poultry product food safety.2. the Chinese prescription of being reported, or the medicine of Chinese medicine and western medicine coupling only are the apparent symptom prescriptions to proventriculitis, gizzard erosion, on the principles of formulating prescriptions, do not consider the base therapy principle that nourishing the stomach must first spleen invigorating, thereby are difficult to radical cure.
Summary of the invention
In view of the deficiency of prior art, the objective of the invention is to provides a kind of Chinese medicine composition of preventing and treating poultry proventriculitis, gizzard erosion through prescription again after the Chinese medicine pharmacology is studied.Said composition is as a kind of pure Chinese medicinal preparation, to effective control poultry proventriculitis, gizzard erosion, and reduce antibacterials in the poultry farming process use, to reduce drug residue etc. significant.
In order to solve the existing problem of background technology, the present invention adopts following technical scheme:
A kind ofly be used to prevent and treat that poultry is evil violates the Chinese medicine composition that lung is defended card, be prepared from the active component of following weight portion: Rhizoma Atractylodis 30-60 part, Radix Astragali 30-50 part, Poria 15-30 part, Pericarpium Citri Reticulatae 15-30 part, Radix Glycyrrhizae 10-25 part.
Preferably, describedly be used to prevent and treat that poultry is evil violates the Chinese medicine composition that lung is defended card, be prepared from the active component of following weight portion: Rhizoma Atractylodis 40-50 part, Radix Astragali 30-45 part, Poria 15-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Glycyrrhizae 10-20 part.
Further preferably, describedly be used to prevent and treat that poultry is evil violates the Chinese medicine composition that lung is defended card, be prepared from the active component of following weight portion: Rhizoma Atractylodis 40-50 part, Radix Astragali 30-40 part, Poria 20-25 part, Pericarpium Citri Reticulatae 20-25 part, Radix Glycyrrhizae 15-20 part.
The present invention presses the general production technology of veterinary drug powder and produces the Chinese powder medicine of preparation, feeds or boiled water dashes stewing, the poultry of feeding after decocting through spice, in case manage a household fowl proventriculitis, gizzard erosion.
The present invention is prepared into oral liquid by the general production technology production of veterinary drug oral liquid, also can produce the granule of preparation according to the veterinary drug granule technological process of production.
Therefore, the described Chinese medicine composition that is used to prevent and treat poultry proventriculitis, gizzard erosion, it is powder, granule or oral liquid.Described poultry is chicken, duck, goose or Carnis Coturnicis japonicae.
According to the record of Chinese medicine historical data, above-mentioned 5 flavor Chinese crude drugs have following pharmacologically active and function cures mainly:
Rhizoma Atractylodis: the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodes lancea (Thunb.) DC. or Atractylis chinensis Atractylodes chinensis (DC.) Koidz. is used as medicine.The property hot, bitter, temperature is returned spleen, stomach, Liver Channel.Function is drying damp and strengthening spleen, and expelling wind and cold cures mainly diseases such as the spleen and stomach being stranded by dampness, inappetence, damp invasion of lower energizer.
The Radix Astragali: have benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak to be used to treat the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.
Poria: the dry sclerotia with Polyporaceae fungus Poria Poria cocos (Schw.) Wolf is used as medicine.The property sweet, light, flat, GUIXIN, lung, spleen, kidney channel.The function promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming.Be used for insufficiency of the spleen lack of appetite, loose stool disease such as have loose bowels.
Pericarpium Citri Reticulatae: have regulating qi-flowing for strengthening spleen, in the accent, dampness, expectorant effect.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in the turbid damp resistance.Phlegm-damp is stopped up the cough and asthma of lung.Select dry mature skin for use for rutaceae orange and variety thereof.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Select Fisch. for use, Glycyrrhiza inflata Bat. G. inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G. glabra L. for dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis.
Compared with prior art; The Chinese medicine composition that being used to of the present invention relates to prevented and treated poultry proventriculitis, gizzard erosion has following advantage and marked improvement: 1. according to the dialectical relationship that The spleen and the stomach are interior-exteriorly related; To poultry proventriculitis, gizzard erosion symptom at gastrointestinal tract and root in the characteristics of dysfunction of the spleen in transportation; With the strengthening the spleen and nourishing the stomach is basic principle, through the spleen invigorating QI invigorating, realizes the target of treating both the principal and secondary aspects of a disease.2. Chinese medicine composition disclosed by the invention is prepared from 5 flavor Chinese crude drugs, and raw material is simple and easy to, and cost is lower, and is economic and practical.3. this prescription is monarch with Rhizoma Atractylodis drying damp and strengthening spleen, expelling wind and cold; The Radix Astragali with benefiting QI for strengthening the superficies, holder skin ulcer granulation promoting is a minister; Assistant is with the Poria of promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming and have the Pericarpium Citri Reticulatae of regulating qi-flowing for strengthening spleen; With the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription of invigorating the spleen and replenishing QI, be adapted to the control needs in proventriculitis, gizzard erosion different onset stage.4. the present invention is a pure Chinese medicinal preparation, and to the effectively antibiotic use of minimizing in the poultry farming process, and it is significant to reduce drug residue.
The specific embodiment
Below be specific embodiment of the present invention, technical scheme of the present invention is done further the description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment one: the preparation of Chinese powder medicine
Chinese medicine composition is by 30 parts of the Radixs Astragali, 50 parts of the Rhizoma Atractylodis Macrocephalaes, windproof 15 parts, 30 parts of Pericarpium Citri Reticulataes, 10 parts of compositions of Radix Glycyrrhizae.The said Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary drug allusion quotation " related standards, and each ratio is weight portion.Each Chinese medicine is mixed pulverizing, cross 60 orders and revolve the sieve that shakes, thicker Chinese medicinal granule is pulverized once more, always mixes the Chinese medicine fine powder, is packed as the 1kg/ bag, promptly gets.Chinese powder medicine by this method production; The mode of generally feeding through spice is used for the evil lung of violating of poultry such as broiler, laying hen, duck and defends the card control; When being used to treat, can also this powder doubly being measured boiled water with 8-10 and dash supernatant drinking-water stewing 30 minutes; The medicinal residues spice is for the respiratory tract infection total effective rate more than 92% of outbreak repeatedly.
Embodiment two: the preparation of Chinese medicine oral liquid
Chinese medicine composition is by 60 parts of the Radixs Astragali, 30 parts of the Rhizoma Atractylodis Macrocephalaes, windproof 30 parts, 15 parts of Pericarpium Citri Reticulataes, 25 parts of compositions of Radix Glycyrrhizae.The said Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary drug allusion quotation " related standards, and each ratio is weight portion.Each Chinese medicine is added 10 times of amounts (weight ratio) purified water soaked 5 hours, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches; Add 8 times of amounts (weight ratio) purified water again and be heated to boiling, be incubated 1 hour, filter, merge filtrating twice; Heating is concentrated into crude drug than for 0.5kg/L, adds ethanol to 75% (volume ratio), precipitates 12 hours, supernatant heating recovery ethanol; And medicinal liquid is concentrated into crude drug than for 1kg/L, and it is anticorrosion to add 0.3% sodium benzoate, and fill, gland promptly get.By the Chinese medicine oral liquid that this method is produced, can directly use through drinking-water, because Chinese medicine is handled through extracting, have onset characteristics rapidly.
Embodiment three: the preparation of Chinese medicine granules
Chinese medicine composition is by 50 parts of the Radixs Astragali, 40 parts of the Rhizoma Atractylodis Macrocephalaes, windproof 25 parts, 25 parts of Pericarpium Citri Reticulataes, 20 parts of compositions of Radix Glycyrrhizae.The said Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary drug allusion quotation " related standards, and each ratio is weight portion.Each Chinese medicine is added 10 times of amounts (weight ratio) purified water soaked 5 hours, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches; Add 8 times of amounts (weight ratio) purified water again and be heated to boiling, be incubated 1 hour, filter, merge filtrating twice; Heating is concentrated into crude drug than for 0.5kg/L, adds ethanol to 75% (volume ratio), precipitates 12 hours, supernatant heating recovery ethanol; And medicinal liquid is concentrated into crude drug than for 5kg/L, and add an amount of sucrose or glucose, granulate; The granule that crude drug content is 1kg/kg is processed in oven dry, and packing promptly gets.Characteristics such as by the Chinese medicine granules of this method preparation, the aquation of can heating during application is opened, and feeds through drinking-water, and it is rapid to have an onset, and accumulating is convenient.
Embodiment four: the evil criminal of traditional Chinese medicine composition for treating chicken of the present invention lung is defended the clinical practice example of card
For verifying the clinical efficacy of Chinese prescription according to the invention, select amoxicillin and cimetidine (cimetidine) that veterinary drug market has good result as the positive control medicine, carried out contrast test.In view of proventriculitis, gizzard erosion are difficult to set up the animal model of poultry through artificial challenge's mode, and such disease is multiple on the veterinary clinic, makes an experiment so selection possesses the morbidity animal of the plant of contrast test condition, natural occurrence.
1. materials and methods
1.1 test material
Chinese powder medicine is pressed embodiment 1 said method preparation; Chinese medicine oral liquid is pressed embodiment 2 said method preparations; Chinese medicine granules is pressed embodiment 3 said method preparations.
The positive control medicine: amoxicillin, cimetidine soluble powder, by plant available from Lukang Medical Co., Ltd., Shandong.
Experimental animal is 21 age in days commercial meat birds of morbidity, meets proventriculitis, gizzard erosion disease through cuing open the inspection diagnosis.
1.2 test method
Luo Si 308 commodity white plumage broiler 24634 plumages of generation of 24 age in days natural infections morbidity are diagnosed as proventriculitis, gizzard erosion through cuing open inspection, are divided into 4 groups at random.Wherein, two hen houses of positive controls, totally 9867 plumages, cimetidine soluble powder, the administration of amoxicillin by specification drinking-water, every day 1 time, logotype 5 days was a course of treatment.
1 hen house 4906 plumage of Chinese powder medicine group are pressed the 1.5g/kg body weight and are calculated dosage.Chinese medicine is directly admixed feedstuff and is fed, and every day 1 time, logotype 5 days was a course of treatment.
Each 1 hen house of Chinese medicine oral liquid group and Chinese medicine granules group, amount of livestock on hand is respectively 4963 plumages and 4898 plumages, with the crude drug cubage, presses the 1.5g/kg body weight and calculates dosage.Every day 1 time, logotype 5 days was a course of treatment.
2. result of the test
2.1 morbidity chicken public sentiment condition and diagnosis
Therapeutic test is that the Shandong Pingdu is cultured 24 age in days Luo Si, the 308 commodity white plumage broiler of generation of raising the sub-district with animal.This breed sub-district has 6 hen houses, every about 5000 plumages of hen house livestock on hand broiler.Raising to 14 age in days carries out a little less than the fabricius bursa after the malicious Seedling immunity, and wherein 5 hen houses material occurs increasing slowly or material reducing, fragmentary dead successively, the incidence that thin and weak chicken is increased.Adopt astragalus polysaccharides, ciprofloxacin control course of treatment (7 days), fail effectively to improve advancing of disease.Death is increased to about 2% suddenly during to 23 ages in days.The chicken that dies of illness is cutd open the visible glandular stomach height swelling of inspection, outward appearance is creamy white, and severe patient is aubergine; Glandular stomach nipple mucosa edema, serious erosion or ulcer; The muscular stomach atrophy, no food or small amounts of food is arranged separates with the flesh layer; Digestive tract has petechia in various degree, pancreas, gallbladder enlargement; Larynx, tracheorrhagia, toughness secretions in the nasal cavity.Chicken crowd's incidence and cut open the inspection symptom and meet the performance of proventriculitis, gizzard erosion disease.
2.2 contrast test
This plant this type of disease habitually in the past is also multiple, adopts broad spectrum antibiotic to combine cimetidine antiviral Comprehensive Treatment traditionally, and what may command was dead to a certain extent continues to increase, but the course of treatment is longer, and the later stage death rate is high.Warp is consulted with the technical staff of plant, and 5 hen houses of falling ill are carried out the curative effect contrast test.Wherein, 2 hen houses adopt cimetidine to cooperate the amoxicillin, as positive controls; Other 3 hen houses are selected to use Chinese powder medicine, Chinese medicine granules and Chinese medicine oral liquid as experimental group respectively at random.The mortality rate that matched group and each experimental group were all added up in the course of treatment (5 days) is as shown in table 1.
Table 1 herbal mixture and antibacterial therapy result (5 days statistical datas)
| Group | Sample number (plumage) * | Death toll (plumage) | Mortality rate (%) |
| Positive controls I | 4972 | 401 | 8.1% |
| Positive controls II | 4895 | 372 | 7.6% |
| Chinese powder medicine | 4906 | 98 | 2.0% |
| Chinese medicine oral liquid | 4963 | 89 | 1.8% |
| Chinese medicine granules | 4898 | 77 | 1.6% |
* each experimental group sample number system is advanced young number by each hen house, deducts the dead number of washing in a pan of accumulative total and calculates and get
That two positive controls adopt is antibiotic, behind the antiviral therapy, mortality rate descends to some extent, until medication the 5th day, each hen house still has 8-10 death only.Chinese powder medicine experimental group, medication death basically occurs after the 4th day again, and Chinese medicine oral liquid, the medication of Chinese medicine granules experimental group basically occur dead after the 3rd day.Show that Chinese drug-treated group of the present invention is the development of control disease effectively, and Chinese medicine is after extracting, onset is very fast.
After answer plant's requirement, two positive controls also adopt the Chinese powder medicine treatment, death has effectively been controlled in logotype after 3 days.When after this raising to 35 ages in days, 6 hen houses of plant are with Chinese powder medicine spice prevention, and dosage reduces by half, and logotype 5 days was delivered for sale to 45 days and similar conditions not occurred, had further verified the effect of this Chinese medicine.
Claims (5)
1. Chinese medicine composition that is used to prevent and treat poultry proventriculitis gizzard erosion; It is characterized in that: this Chinese medicine composition is prepared from the active component of following weight portion: Rhizoma Atractylodis 30-60 part, Radix Astragali 30-50 part, Poria 15-30 part; Pericarpium Citri Reticulatae 15-30 part, Radix Glycyrrhizae 10-25 part.
2. the Chinese medicine composition that is used to prevent and treat poultry proventriculitis gizzard erosion according to claim 1; It is characterized in that: this Chinese medicine composition is prepared from the active component of following weight portion: Rhizoma Atractylodis 40-50 part, Radix Astragali 30-45 part, Poria 15-25 part; Pericarpium Citri Reticulatae 15-25 part, Radix Glycyrrhizae 10-20 part.
3. the Chinese medicine composition that is used to prevent and treat poultry proventriculitis gizzard erosion according to claim 2; It is characterized in that: this Chinese medicine composition is prepared from the active component of following weight portion: Rhizoma Atractylodis 40-50 part, Radix Astragali 30-40 part, Poria 20-25 part; Pericarpium Citri Reticulatae 20-25 part, Radix Glycyrrhizae 15-20 part.
4. according to each described Chinese medicine composition that is used to prevent and treat poultry proventriculitis gizzard erosion of claim 1-3, it is characterized in that: this Chinese medicine composition is powder, granule or oral liquid.
5. according to each described Chinese medicine composition that is used to prevent and treat poultry proventriculitis gizzard erosion of claim 1-3, it is characterized in that: described poultry is chicken, duck, goose or Carnis Coturnicis japonicae.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860890A (en) * | 2012-12-13 | 2014-06-18 | 辽宁农业职业技术学院 | Traditional Chinese medicine for treating chicken proventriculitis and ventriculitis |
| CN104489417A (en) * | 2015-01-14 | 2015-04-08 | 安徽科技学院 | Chinese herbal medicine feed additive capable of promoting growth of muscles of broiler chickens |
| CN105168811A (en) * | 2015-08-06 | 2015-12-23 | 黄淮学院 | Traditional Chinese medicine soluble powder for controlling infectious proventriculitis and ventriculitis in broiler chicken and preparation method thereof |
| CN105194163A (en) * | 2015-10-21 | 2015-12-30 | 北京康华远景科技股份有限公司 | Medicine composition for preventing and treating proventriculitis of chicken and preparation method thereof |
| CN105412803A (en) * | 2016-01-20 | 2016-03-23 | 山东迅达康生物科技有限公司 | Medicinal composition and preparation for treating poultry proventriculitis |
| CN106421036A (en) * | 2016-08-31 | 2017-02-22 | 旌德县德源农业开发有限公司 | Traditional Chinese medicinal composition for treating chicken gizzard erosion |
| CN110755492A (en) * | 2019-10-23 | 2020-02-07 | 潍坊市华程生物科技有限公司 | Medicinal plant essential oil composition for preventing and treating poultry gastrointestinal damp-heat disease |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860890A (en) * | 2012-12-13 | 2014-06-18 | 辽宁农业职业技术学院 | Traditional Chinese medicine for treating chicken proventriculitis and ventriculitis |
| CN104489417A (en) * | 2015-01-14 | 2015-04-08 | 安徽科技学院 | Chinese herbal medicine feed additive capable of promoting growth of muscles of broiler chickens |
| CN105168811A (en) * | 2015-08-06 | 2015-12-23 | 黄淮学院 | Traditional Chinese medicine soluble powder for controlling infectious proventriculitis and ventriculitis in broiler chicken and preparation method thereof |
| CN105168811B (en) * | 2015-08-06 | 2018-05-01 | 黄淮学院 | A kind of Chinese medicine soluble powder for preventing broiler chicken chicken infectious provenculitis-ventriculitis and preparation method thereof |
| CN105194163A (en) * | 2015-10-21 | 2015-12-30 | 北京康华远景科技股份有限公司 | Medicine composition for preventing and treating proventriculitis of chicken and preparation method thereof |
| CN105412803A (en) * | 2016-01-20 | 2016-03-23 | 山东迅达康生物科技有限公司 | Medicinal composition and preparation for treating poultry proventriculitis |
| CN106421036A (en) * | 2016-08-31 | 2017-02-22 | 旌德县德源农业开发有限公司 | Traditional Chinese medicinal composition for treating chicken gizzard erosion |
| CN110755492A (en) * | 2019-10-23 | 2020-02-07 | 潍坊市华程生物科技有限公司 | Medicinal plant essential oil composition for preventing and treating poultry gastrointestinal damp-heat disease |
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Application publication date: 20120822 |