CN105168811A - Traditional Chinese medicine soluble powder for controlling infectious proventriculitis and ventriculitis in broiler chicken and preparation method thereof - Google Patents
Traditional Chinese medicine soluble powder for controlling infectious proventriculitis and ventriculitis in broiler chicken and preparation method thereof Download PDFInfo
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Abstract
The invention relates to traditional Chinese medicine soluble powder for controlling infectious proventriculitis and ventriculitis in broiler chicken and a preparation method thereof. The soluble powder is made from, by weight, 8% of Astragalus root, 8% of root of hairy Asiabell, 8% of fried licorice root, 8% of common Anemarrhena rhizome, 8% of lightyellow Sophora root, 8% of Baical skullcap root, 8% of Chinese cork tree bark, 8% of jasmine fruit, 8% of cuttlebone, 4.8% of Chinese Atractylodes rhizome, 4.8% of fried peony root, 4.8% of weeping Forsythiae capsule, 4.8% of figwort root, 4.8% of Chinese goldthread rhizome, and 4% of tangerine peel. The raw materials are decocted, filtered, frozen and crushed into the soluble powder. The soluble powder as a traditional Chinese medicine preparation is capable of effectively controlling the occurrence and development of infectious proventriculitis and ventriculitis in broiler chicken, capable of treating both symptoms and root causes, high in cure rate, convenient to dose and free of drug resistance and drug residue; the soluble powder helps improve gastrointestinal function and immunity of the chicken, decrease death rate and feed conversion ratio and increase slaughter weight.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, specifically the Chinese medicine soluble powder of birds, is further a kind ofly prevent and treat Chinese medicine soluble powder of broiler infectious proventriculitis-ventriculitis and preparation method thereof.
Background technology
Since two thousand six, white meat-type chickens cultivation City Regions on Liaoning of China, Shandong, Hebei, Jilin, Heilungkiang, Henan and other places occurs that broiler feed intake is low, poor growth, chicken feet turn white successively, glandular stomach wall thickening, the enlargement of glandular stomach nipple, the symptoms such as serious appearance Endothelium Corneum Gigeriae Galli ulcer are main a kind of disease.Animal and veterinary practitioner finally unification is named as broiler infectious proventriculitis (InfectiousProventriculitis, IP).The ventriculitis (MuscleGastritis) of this disease and secondary thereof is very large to broiler harm, improves feedstuff-meat ratio, reduces the premunition of broiler.
The fact that relevant animal medicine manufacturer extremely raises for acidity in the broiler gastric juice of this disease of trouble, the infectious proventriculitis medicine released, mainly with the compound preparation of cimetidine, antibiotic, antiviral drugs, reparation mucous membrane agent composition, but the effect of the development delaying broiler infectious proventriculitis can only be played, obviously can not reach the effect hindering broiler infectious proventriculitis that development occurs.But since in March, 2014 " The Ministry of Agriculture of the People's Republic of China, MOA announces No. 2071 " file performs, forbid the regulation of " change prescription adds other veterinary drug compositions ", the effect of drugs for the treatment of broiler infectious proventriculitis is declined, cause the harm of infectious proventriculitis to broiler increasing, cause serious economic loss to broiler breeding industry.
Because IP has morbidity early, the feature that the persistent period is long, brings very burden to control.Medicine is the Main Means of control broiler infectious proventriculitis-ventriculitis, and in order to the generation of effective this disease of prevention and corntrol, the control of current broiler breeding field (family) to broiler infectious proventriculitis-ventriculitis has all dropped into a large amount of funds.Due to the cause of disease of broiler infectious proventriculitis-ventriculitis or the multiformity (uncertainty) of the cause of disease, there is no effective prevention method.Existing protective agents mainly for broiler infectious proventriculitis, but develops without effectively preventing method the generation of ventriculitis.
Traditional Chinese veterinary medicine is of extensive knowledge and profound scholarship, disease therapy is particular about entirety and treating both the principal and secondary aspects of a disease, Chinese medicine is more and more applied to the control of animal epidemic due to its efficient, low drug residue, therefore, a Chinese prescription is worked out to prevent and treat the main task that broiler infectious proventriculitis-ventriculitis becomes veterinary industry.Although the control that Chinese medicine is used for IP there has been a large amount of research work, but be main mainly with powder in the prescription reported, dispensing is inconvenient, and affect the treatment, certain difficulty is had to broiler infectious proventriculitis-ventriculitis control, therefore, develop collection symptomatic treatment, antitoxin, antibacterial, antiulcer, efficient, nontoxic, be convenient to the novel protective agents tool that intensive culture is used in one and be of great significance.
Since 2008, the first inventor as the technical specialist of certain well-known animal health-care product enterprise domestic, the technical service in primary responsibility broiler market.The case of broiler infectious proventriculitis-ventriculitis that to have utilized Chinese medicinal formulae to cure a large amount of.In the research of education department of the Henan Province scientific and technical research key project that school carries out, find the mechanism that the gastric acid secretion that infectious proventriculitis brings out ventriculitis increases, and the reason causing muscular stomach class cutin membrane self-protection power to decline.Explore can the Chinese medicinal formulae of the above-mentioned factor of antagonism preventing and treating broiler infectious proventriculitis-ventriculitis.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, and provide a kind for the treatment of both the principal and secondary aspects of a disease, cure rate high, and dispensing is convenient, does not develop immunity to drugs, drug residue free; Can improve broiler gastrointestinal function and immunocompetence, reduce mortality rate, reduce feedstuff-meat ratio, raising is delivered weigh a kind of for sale and is prevented and treated Chinese medicine soluble powder of broiler infectious proventriculitis-ventriculitis and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
A kind of Chinese medicine soluble powder preventing and treating broiler infectious proventriculitis-ventriculitis, it is made up of the raw material of Chinese medicine of following weight percentage ratio: the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae Preparata, the Rhizoma Anemarrhenae, Radix Sophorae Flavescentis, Radix Scutellariae, Cortex Phellodendri, Fructus Gardeniae, Os Sepiae each 8%, Rhizoma Atractylodis, process Radix Paeoniae, Fructus Forsythiae, Radix Scrophulariae, Rhizoma Coptidis each 4.8%, Pericarpium Citri Reticulatae 4%.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, comprise the steps: to take raw material of Chinese medicine 1 part by weight ratio, decoct twice.First time decocts: 1 part, Chinese medicine, 8 parts, water, and soak 30min, intense fire boils, and changes slow fire boiling 60min into, filtering liquid medicine; Second time decocts: in first time medicinal residues, add water 6 parts, intense fire boils, and changes slow fire boiling 45min into; Collecting decoction, filters, solidifies, in frozen vacuum dryer, make powder in-20 DEG C of environment.Chinese medicine powder 68 parts, adjuvant 32 parts, whole mistake 80 object pulverizer, makes soluble powder.Every 150g soluble powder is a packaging unit.
Aforesaid adjuvant is glucose powder.
Prevention usage and dosage: 1-5 age in days, every packaging unit is the dosage that 5000 chickling use 1d, and whole day is drunk, and 2-3h changes and once drinks water, and faces and is added to the water with by soluble powder.9-11 age in days, every packaging unit is the dosage that 2500 broiler use 1d, with the 1-2h that front cuts off the water, concentrates 2-3h to drink, is used in conjunction 3d.
Treatment usage and dosage: every packaging unit is the dosage (being equivalent to add in daily ration the Chinese powder medicine of 0.4%) of the heavy broiler 1d of 500 1.5Kg.With the 1-2h that front cuts off the water, concentrate 2-3h to drink, be used in conjunction 3-5d.
This Chinese prescription has effect of heat-clearing and toxic substances removing, invigorating the spleen to arrest diarrhea, QI invigorating stomach function regulating, antiulcer, relieving gastric hyperacidity to alleviate stomachache.
Have replenishing QI to invigorate the spleen in prescription, the medicine of regulating qi-flowing for harmonizing stomach function has the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae Preparata, Rhizoma Atractylodis, Pericarpium Citri Reticulatae.By the use in conjunction of these Chinese medicines, reach the object improving glandular stomach, muscular stomach function, promote glandular stomach functional recovery, reduce gastric acid secretion.Wherein Radix Glycyrrhizae Preparata has inhibitory action to gastroxia in addition; And have effect that is antiacid and alleviation gastrointestinal smooth muscle spasm.Have heat-clearing and toxic substances removing, the Chinese medicine of antibiosis and antiviral functions has: Radix Sophorae Flavescentis, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Gardeniae, Fructus Forsythiae, Radix Scrophulariae.Can coordinate to resist the microorganism cause of disease that may cause broiler infectious proventriculitis, prevent deuteropathic development simultaneously.Wherein Rhizoma Coptidis and Cortex Phellodendri also have antiulcer action, contribute to the healing of the erosion of muscular stomach class cutin membrane, ulcer.There is the Rhizoma Anemarrhenae of clearing heat in QI system pathogenic fire purging effect and have the Radix Rehmanniae of nourishing and enriching blood effect, process Radix Paeoniae, better can play effect of drugs.There is astringing to arrest bleeding, relieving gastric hyperacidity to alleviate stomachache, the Os Sepiae of removing dampness sore effect, on the basis contributing to Endothelium Corneum Gigeriae Galli ulcer healing, nurse one's health the acid-base value in muscular stomach, glandular stomach together with Radix Glycyrrhizae Preparata.
The present invention is according to the pathogenesis of broiler infectious proventriculitis-ventriculitis and disease symptom; Chinese prescription is drafted in conjunction with Chinese veterinarian's organic conception and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs theory; then to treat and prevention & protection test shows suffering from the broiler of infectious proventriculitis-ventriculitis with feeding experiment Study of Traditional Chinese Medicine prescription; this invention obviously can reduce the generation of broiler infectious proventriculitis-ventriculitis, and can significantly improve the meat feed ratio of broiler and deliver for sale heavily.To the treatment of suffering from infectious proventriculitis-ventriculitis broiler, curative effect is obvious.This soluble powder preparation technique is simple, with low cost, facilitates pharmaceutical manufacturer to produce in enormous quantities; Soluble in water, easy to use and safety, facilitates broiler intensive manufacture to use.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1 safety testing
A kind of Chinese medicine soluble powder preventing and treating broiler infectious proventriculitis-ventriculitis, it is made up of the raw material of Chinese medicine of following weight percentage ratio: the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae Preparata, the Rhizoma Anemarrhenae, Radix Sophorae Flavescentis, Radix Scutellariae, Cortex Phellodendri, Fructus Gardeniae, Os Sepiae each 8%, Rhizoma Atractylodis, process Radix Paeoniae, Fructus Forsythiae, Radix Scrophulariae, Rhizoma Coptidis each 4.8%, Pericarpium Citri Reticulatae 4%.
The preparation method of above-mentioned Chinese medicine preparation, comprises the steps: to take raw material of Chinese medicine 1 part by weight ratio, decocts twice.First time decocts: 1 part, Chinese medicine, 8 parts, water, and soak 30min, intense fire boils, and changes slow fire boiling 60min into, filtering liquid medicine; Second time decocts: in first time medicinal residues, add water 6 parts, intense fire boils, and changes slow fire boiling 45min into; Collecting decoction, filters, solidifies, in frozen vacuum dryer, make powder in-20 DEG C of environment.Chinese medicine powder 68 parts, adjuvant 32 parts, whole mistake 80 object pulverizer, makes soluble powder.Every 150g soluble powder is a packaging unit.
Aforementioned adjuvant is glucose powder.
1.1 acute toxicity test
18-22g Kunming white mice 10, male and female half and half.White mice fasting 12h, freely drinks water.Soluble powder is mixed with the aqueous solution of 10%, gavages administration, each 0.4mL, interval 2h is administered once, successive administration 3 times.Observe 24h, do not find mice dying.Total dosage 0.12g/20gBW (6000mg/kgBW).Repeating 2 times, all not there is death in white mice.
Soluble powder LD of the present invention is described
50> 5000mg/kgBW.
1.2 subchronic toxicity test
18-22g Kunming white mice 80, male and female half and half.White mice is divided at random 4 groups, often organizes 20, male and female half and half.White mice fasting 12h, freely drinks water.
Soluble powder distilled water of the present invention gavages white mice after dissolving.The processing method of each group of white mice, refers to table 1.
The processing method of white mice respectively organized by table 1
The process of each group of timing every day gavage.Each group of continuous gavage 14d, continuous observation 14d again after drug withdrawal.Observe the general status of mice every day, measure body weight change situation weekly.
1.2.1 the method for subchronic toxicity test
After drug withdrawal the 1st day and the 14th day, randomly draw 10 blood samplings, measure total white blood cells, lymphocyte number, mononuclear cell number, hemoglobin, platelet, packed cell volume and Erythrocytes content immediately for each group.
After drug withdrawal the 1st day and 14 days, often group randomly drawed 10 blood samplings, separation of serum.
Enzymic creatinine assay method is utilized to measure the content of creatinine; Reitman-frankel method is utilized to measure the content of glutamate pyruvate transaminase; Microplate method is utilized to measure the content of glutamic oxaloacetic transaminase, GOT; Urease method is utilized to measure the content of blood urea nitrogen.
1.2.2 subchronic toxicity test results and analysis
Experimental session does not find that each group of white mice has abnormal conditions to occur.Compared with matched group, experimental group I, experimental group II and experimental group III body weight slightly raise, but each group difference is not significantly (P > 0.05).
The determination data of statistics software to each group of white mice routine blood test part index number is utilized to analyze.Particular content refers to table 2.
Within after table 2 drug withdrawal 1 day, respectively organize the measurement result of white mice routine blood test part index number
As shown in Table 2, compared with matched group, the total white blood cells of each experimental mice, lymphocyte number, mononuclear cell number, hemoglobin, platelet, packed cell volume and Erythrocytes slightly increase, but difference is not significantly (P > 0.05).
After drug withdrawal 14 days, compared with matched group, the total white blood cells of each experimental mice, lymphocyte number, mononuclear cell number, hemoglobin, platelet, packed cell volume and Erythrocytes difference are not significantly (P > 0.05).
The determination data of statistics software to each group of mouse serum biochemical indicator is utilized to analyze.Particular content refers to table 3.
Within after table 3 drug withdrawal 1 day, respectively organize the measurement result of mouse serum biochemical indicator
As shown in Table 3, compared with matched group, each experimental mice serum alt, AST, Cr, BUN slightly increase, but difference is not significantly (P > 0.05).
After drug withdrawal 14 days, compared with matched group, the serum alt of each experimental mice, AST, Cr, BUN difference were not significantly (P > 0.05).
1.2.3 conclusion
During subchronic toxicity testing, observe each experimental group white mice growth promoter good, various sign is acted normally.Soluble powder of the present invention does not all make significant difference to white mice body weight, blood glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST), blood urea nitrogen (BUN) and creatinine (Cr).
1.3 long term toxicity test
1.3.1 long term toxicity test method
Soluble powder of the present invention adds in basal diet by the ratio in 4%, makes the feedstuff containing soluble powder of the present invention.
18-22g Kunming white mice 40, male and female half and half.White mice is divided at random 2 groups, often organizes 20, male and female half and half.The processing method of each group of white mice, refers to table 4.
The processing method of white mice respectively organized by table 4
Each group every day timing feeding.After experiment starts, observe every day and record the general performance of animal, behavior, poisoning manifestations and death condition.Fasting at dusk in 60th day, can't help water.
Fasting 12h eye socket gets blood, separation of serum, measures the content of glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT, blood urea nitrogen, creatinine.
After mice dying, be separated organ, measure the weight of liver, kidney and spleen.
1.3.2 long term toxicity test result
Experimental session does not find that each group of white mice has abnormal conditions to occur.Compared with matched group, experimental group weight differences is not significantly (P > 0.05).
The measurement result of each group of mouse serum biochemical indicator refers to table 5.
The measurement result of mouse serum biochemical indicator respectively organized by table 5
As shown in Table 5, compared with matched group, experimental mice serum alt, AST, Cr, BUN difference are not significantly (P > 0.05).
The measurement result of each group of white mice organ weight refers to table 6.
The measurement result of white mice organ weight respectively organized by table 6
As shown in Table 6, compared with matched group, the weight differences of experimental mice liver, kidney and spleen is not significantly (P > 0.05).
1.3.3 long term toxicity test conclusion
During long term toxicity test, observation experiment group white mice growth promoter is good, and various sign is acted normally.Soluble powder of the present invention does not all make significant difference to the body weight of white mice body weight, part internal organs, blood glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST), blood urea nitrogen (BUN) and creatinine (Cr).
The conclusion of 1.4 safety testings
Proved by the safety test (acute toxicity test, subchronic toxicity test and long term toxicity test) of soluble powder of the present invention, soluble powder of the present invention is safe and reliable, can relieved use in animal productiong.
Embodiment 2 prevents and treats the test of broiler infectious proventriculitis-ventriculitis
The raw material of Chinese medicine of Chinese medicine soluble powder is made with preparation method with embodiment 1.
The test method of 2.1 control broiler infectious proventriculitis-ventriculitis
160 omnidistance free choice feedings of broiler, 50 broiler are matched group, male and female half and half.50 broiler are prevention group, male and female half and half.60 broiler are treatment group, male and female half and half.
Prevention group 1-5 age in days, every 1.5 grams of soluble powders of the present invention use the dosage of 1d, and whole day is drunk, and 2-3h changes and once drinks water, and faces and is added to the water with by soluble powder.9-11 age in days, every 3 grams of soluble powders of the present invention use the dosage of 1d, with the 1-2h that front cuts off the water, concentrate 2-3h to drink, are used in conjunction 3d.
The glandular stomach supernatant 1.5mL/ that prevention group and treatment group 5-9 age in days broiler chicken start to gavage infectious proventriculitis broiler is only secondary, and 2 times/day, feedstuff 3% vinegar sprays, micro-tide.Free choice feeding, 24h illumination.Each group of broiler chicken processing method, refers to table 7.
Table 7 is group broiler chicken processing method respectively
Note: each group broiler each stage daily ration is certain same batch products of well-known feed companies domestic.
Experimental group broiler 8 age in days feed intake does not increase, and 9 ages in days are not of uniform size as seen, contracting neck, and beak and lower limb yellow go down, and feedstuff just or fine strip shape feces.Matched group and prevention group broiler without exception.Only have the broiler chicken of clinical symptoms to cut open inspection to experimental group 10, find glandular stomach enlargement, nipple is obvious, and muscular stomach class cutin membrane thickens.Experimental group broiler can be made a definite diagnosis and suffer from infectious proventriculitis.
The result of the test of 2.2 control broiler infectious proventriculitis-ventriculitis
Add up the broiler that each group has infectious proventriculitis clinical symptoms, obtain the sickness rate of each group, refer to table 8.
Table 8 is group incidence statistical table respectively
As shown in Table 8, prevention group broiler is not suffered from broiler and is suffered from infectious proventriculitis.And the broiler of the counteracting toxic substances group (experimental group) of not preventing suffers from the sickness rate of infectious proventriculitis up to 90%.
10 ages in days start to treat experimental group 50 broiler, and soluble powder of the present invention 5 grams is the dosage of 50 broiler 1d.With the 1-2h that front cuts off the water, concentrate 2-3h to drink, be used in conjunction 3-5d.12 age in days feed intakes start to recover, and 14 age in days feed intakes return to the same with prevention group with matched group.The clinical symptom disappearance of infectious proventriculitis suffered from by broiler.
The conclusion (of pressure testing) of 2.3 control broiler infectious proventriculitis-ventriculitis
Soluble powder of the present invention uses at 1-5 age in days, 9-11 age in days, and broiler can be prevented to suffer from the generation of infectious proventriculitis.Be used for after morbidity treating, also achieve obvious curative effect.
Above one embodiment of the present of invention have been described in detail, but described content being only preferred embodiment of the present invention, can not being considered to for limiting practical range of the present invention.All equivalent variations of doing according to the present patent application scope and improvement, all due within covering scope of the present invention.
Claims (4)
1. prevent and treat the Chinese medicine soluble powder of broiler infectious proventriculitis-ventriculitis for one kind, it is characterized in that: formed by the raw material of Chinese medicine compatibility of following weight percentage ratio: the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae Preparata, the Rhizoma Anemarrhenae, Radix Sophorae Flavescentis, Radix Scutellariae, Cortex Phellodendri, Fructus Gardeniae, Os Sepiae each 8%, Rhizoma Atractylodis, process Radix Paeoniae, Fructus Forsythiae, Radix Scrophulariae, Rhizoma Coptidis each 4.8%, Pericarpium Citri Reticulatae 4%.
2. the preparation method of Chinese medicine soluble powder, is characterized in that, comprises the steps:
1) take raw material of Chinese medicine 1 part by weight ratio, decoct twice;
2) first time decocts: 1 part, Chinese medicine, 8 parts, water, and soak 30min, intense fire boils, and changes slow fire boiling 60min into, filtering liquid medicine;
3) second time decocts: in first time medicinal residues, add water 6 parts, intense fire boils, and changes slow fire boiling 45min into;
4) collecting decoction, filters;
5) solidify in-20 DEG C of environment, in frozen vacuum dryer, make powder;
6) Chinese medicine powder 68 parts, adjuvant 32 parts, whole mistake 80 object pulverizer, makes soluble powder;
7) every 150g soluble powder is a packaging unit.
3. the preparation method of Chinese medicine soluble powder according to claim 2, is characterized in that: described packaging unit is vacuum packaging, moistureproof storage.
4. the preparation method of Chinese medicine soluble powder according to claim 2, is characterized in that: described adjuvant is glucose powder.
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| CN107184702B (en) * | 2017-07-27 | 2020-07-17 | 北京生泰尔科技股份有限公司 | Traditional Chinese medicine composition for preventing and treating proventriculitis and myogastritis of poultry and preparation method thereof |
| CN107890531A (en) * | 2017-11-17 | 2018-04-10 | 锦州景良动物药业有限公司 | A kind of traditional Chinese medicine oral liquid for treating avian infectious proventriculitis and preparation method thereof |
| CN114246940A (en) * | 2020-09-23 | 2022-03-29 | 洛阳惠中兽药有限公司 | Application of pharmaceutical composition containing kuh-seng mahonia granules |
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