CN107184702A - A kind of Chinese medicine composition for preventing and treating poultry proventriculitis ventriculitis and preparation method thereof - Google Patents
A kind of Chinese medicine composition for preventing and treating poultry proventriculitis ventriculitis and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
The invention discloses a kind of Chinese medicine composition for preventing and treating poultry proventriculitis ventriculitis and preparation method thereof.The Chinese medicine composition is made up of following bulk drug：Honeysuckle, the Radix Astragali, the root of kudzu vine, radix glycyrrhizae, dried orange peel, cape jasmine and corydalis tuber.The Chinese medicine composition that the present invention is provided has clearing heat and detoxicating, regulating qi-flowing for strengthening spleen, damp-heat dysentery, the effect of promoting qi circulation and relieving pain, gastric acid secretion can effectively be adjusted, damage gastric mucosa is repaired, reduction damages loss caused by caused performance of poultry declines and be dead by glandular stomach muscular stomach, be poultry farming increase economic benefit.And medicine, feed or feed addictive can be further made up in the Chinese medicine composition of conventional method, with low cost, the characteristics of convenient for production.
Description
(1) technical field
The invention belongs to technical field of Chinese veterinary medicine, and in particular to a kind of Chinese medicine composition of preventing and treating poultry proventriculitis ventriculitis
And preparation method thereof.
(2) background technology
Proventriculitis ventriculitis is the one kind occurred in China's broiler breeding industry based on the enlargement of glandular stomach inflammatory, gizzard erosion
The illness of feature is wanted, pathological characters show as Hypertrophic, hemorrhagic, gangrenosum acne proventriculitis, the swelling of glandular stomach nipple, soft edge not
Clearly, there is obvious ulcer, necrosis region in muscular stomach.Clinical symptoms show as low feed intake, growth retardation, depauperation, colony
Regularity is poor, feed digestion is bad, waste is serious, immunity of organism is suppressed, it is easy to infect various secondary diseases, from multiple
Aspect causes serious economic loss to aquaculture.Poultry proventriculitis ventriculitis can be by avian infectious proventriculitis virus, Glandular Stomach Type
The many factors such as infectious bronchitis virus, bird pox virus, reovirus, histamine, biogenic amine and mycotoxin contamination cause.
In infection, originally there is feed conversion rate decline in chicken group after being ill, and growth retardation is even stagnated, production performance reduction, easily secondary other diseases
Disease, huge economic loss is brought to culturist.
Effective clinical treatment medicine is had no currently for poultry proventriculitis ventriculitis, the remedy measures mainly taken are to make
With antibiotics, antimicrobial DP finish and H2Receptor antagonist class medicine (such as Cimetidine) is delayed to clinical symptoms
Solution, it is impossible to eradicate and cure.Moreover, pharmaceutical dosage form is mainly the solid dosage forms such as rough machined pulvis.Patent of invention《One kind preventing and treating
The Chinese medicine preparation of poultry proventriculitis ventriculitis》(number of patent application：201310513889.9) disclosed in, by cuttlebone, golden cypress,
It is also pulvis that rheum officinale, the bark of ash, Radix Codonopsis, the Chinese bulbul, the bighead atractylodes rhizome, Poria cocos, radix glycyrrhizae constitute Chinese medicine preparation by certain part by weight, is processed into powder
It is not appropriate for for the agent symptom that feed intake is remarkably decreased when the short physiological characteristic of poultry alimentary canal and morbidity, after use not
Only absorb less, and therapeutic effect is poor.Therefore provide a kind of pure natural, symptom during for poultry physilogical characteristics and morbidity,
And it is extremely urgent fundamentally to treat this sick medicine.
(3) content of the invention
To solve the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition for preventing and treating poultry proventriculitis ventriculitis
And preparation method thereof, the weak point of existing medicine can be not only made up, while having with low cost, suitable poultry physiology concurrently
The characteristics of structure, suitable plant layout metaplasia are produced, while having outstanding therapeutic effect, suitably carrying out clinic in multiple fields pushes away
Wide application.
To reach above-mentioned purpose, this invention takes following technical scheme：
A kind of Chinese medicine composition for preventing and treating poultry proventriculitis ventriculitis and preparation method thereof, it is characterized in that by honeysuckle, Huang
Stilbene, the root of kudzu vine, radix glycyrrhizae, dried orange peel, cape jasmine and corydalis tuber composition, by its listed as parts by weight：10~20 parts of honeysuckle, the Radix Astragali 10~20
Part, 25~40 parts of the root of kudzu vine, 15~35 parts of radix glycyrrhizae, 5~15 parts of dried orange peel, 10~20 parts of cape jasmine, 10~20 parts of corydalis tuber.
As a preferred embodiment of the present invention, each raw material is calculated by weight in Chinese medicine composition：Honeysuckle 10~15
Part, 10~15 parts of the Radix Astragali, 25~30 parts of the root of kudzu vine, 15~25 parts of radix glycyrrhizae, 5~10 parts of dried orange peel, 10~15 parts of cape jasmine, corydalis tuber 10~
15 parts.
As a preferred embodiment of the present invention, each raw material is calculated by weight in Chinese medicine composition：15 parts of honeysuckle, it is yellow
15 parts of stilbene, 30 parts of the root of kudzu vine, 25 parts of radix glycyrrhizae, 10 parts of dried orange peel, 15 parts of cape jasmine, 15 parts of corydalis tuber.
As a preferred embodiment of the present invention, each raw material is calculated by weight in Chinese medicine composition：10 parts of honeysuckle, it is yellow
10 parts of stilbene, 25 parts of the root of kudzu vine, 15 parts of radix glycyrrhizae, 5 parts of dried orange peel, 10 parts of cape jasmine, 10 parts of corydalis tuber.
As a preferred embodiment of the present invention, each raw material is calculated by weight in Chinese medicine composition：20 parts of honeysuckle, Huang
20 parts of stilbene, 40 parts of the root of kudzu vine, 35 parts of radix glycyrrhizae, 15 parts of dried orange peel, 20 parts of cape jasmine, 20 parts of corydalis tuber.
As the preferred plan of the present invention, each raw material is calculated by weight in Chinese medicine composition：14 parts of honeysuckle, the Radix Astragali 14
Part, 26 parts of the root of kudzu vine, 20 parts of radix glycyrrhizae, 7 parts of dried orange peel, 14 parts of cape jasmine, 12 parts of corydalis tuber.
Another object of the present invention, is to provide the preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
(1) the weight relation is pressed, honeysuckle, the Radix Astragali, the root of kudzu vine, radix glycyrrhizae, dried orange peel, cape jasmine and corydalis tuber medicine is weighed
Material.7 taste medicinal materials are distinguished into impurity elimination, weighed, are cleaned, it is 180 μm~600 μm of coarse powder to crush and particle diameter is made, add 3 after merging~
The water of 5 times of weight, soaks 1h-3h；
(2) medicinal material and soak after immersion are added into purified water to 10~15 times of medicinal material weight, carries out ultrasonic extraction；
(3) merge herbal extract, carry out decoction concentration using negative pressure of vacuum method for concentration, be concentrated into the 1~3 of medicinal material amount
After times, pour out, herbal extract is stood into 24h in Cool Room 4 DEG C；
(4) 4 DEG C of standing 24h herbal extract is taken out, online high speed centrifugation is carried out with 10000rpm~16000rpm；
(5) pH value range of centrifugate is adjusted to after 4~6, filtered using miillpore filter, collect filtered solution, plus
Enter auxiliary material to be prepared, filling, sterilizing is carried out after preparation, is got product.
Ultrasonic extraction power is 25kHz~50kHz wherein in step (2), and Extracting temperature is 80 DEG C~100 DEG C, during extraction
Between be 0.5h~1.5h, extraction time be 1~3 time.In step (3) negative pressure of vacuum concentrate vacuum for -0.06Mpa~-
0.1Mpa, temperature is 80 DEG C~90 DEG C.The pore size of miillpore filter is 0.22 μm~0.45 μm in step (5).
It can be extracted during extraction by the way of water or alcohol or the extraction of some drugs water, some drugs alcohol extracting, preferably second
Alcohol.
The Chinese medicine composition of preventing and treating poultry proventriculitis ventriculitis obtained by the present invention can be used for medicine, feed and feed
The fields such as additive.Medicine, feed and feed addictive can be prepared by this area any conventional method.Its formulation includes oral
Liquid, pulvis, granule, powder, Ultramicro-powder, injection, tablet, decoction, pill；Preferably oral liquid.
The Chinese medicine composition of preventing and treating poultry proventriculitis ventriculitis of the present invention is preparing medicine or feed and feed adds
Plus during agent, can by weight, by the pharmaceutically acceptable carrier of Chinese medicine composition 1%~99% and 1%~99% or auxiliary material
Mixing or by the oral liquid customary adjuvant or feed of Chinese medicine composition 50%~80% and 20%~50% and feed addictive
Customary adjuvant is mixed, and oral liquid or pulvis is made using conventional method.Oral liquid customary adjuvant is antioxidant, pH regulations
Agent, preservative and purified water；The customary adjuvant of feed and feed addictive is diluent and preservative.Wherein, antioxidant contains
There are the one or more in sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, sodium thiosulfate, natrium adetate；PH adjusting agent
Contain the one or more such as hydrochloric acid, phosphoric acid and phosphoric acid salt, citric acid and citrate, glacial acetic acid, lactic acid, sodium hydroxide；It is anti-
Rotten agent contains the one or more in benzoic acid, sodium benzoate, parabens, sorbic acid, potassium sorbate；Diluent
Including the one or more in maltodextrin, soluble starch, glucose.
As the traditional Chinese medicine oral liquid obtained by prepared by the Chinese medicine composition of preventing and treating poultry proventriculitis ventriculitis of the present invention
Consumption allows chicken freely to drink to be mixed in 0.2% (v/v) ratio in drinking-water, and it 3~5 days is a course for the treatment of to be used in conjunction.
It is of the invention with it is existing prevention and treatment poultry proventriculitis ventriculitis technique and prescription compared with, with following excellent
Gesture：
1. the present invention process such as crushes, sieved, soak in advance using medicinal material, the removal of impurity, the ratio table of increase medicinal material are effectively gone
Area, significant increase effective substance dissolution rate, while being extracted using ultrasound assisted extraction technique, is a significant increase medicine and carried
The bioactivity of liquid is taken, and technique is easy, saves, efficient, time saving, with short production cycle, greatly reduces production cost.
2. the present invention is with clearing heat and detoxicating, tonifying Qi promoting the circulation of qi be medicine in the rules for the treatment of, prescription selection and consumption by system
Pharmacodynamic study, it is scientific and reasonable, for treatment poultry proventriculitis ventriculitis, with significant effect.
3. the present invention extracts preparation for pure Chinese medicine, chemical drug and antibiotic, nontoxic, drug residue free, environmental protection are not contained.
4. the raw material that the present invention is applied is the common medicinal material of in the market, cheap and easy to get, cost is low, is adapted to clinical expansion
Use.
5. the present invention carries out prescription in herbal medicine theoretical foundation, with clinic of the prior art only for proventriculitis ventriculitis
Symptom carries out treatment difference, is treated by verifying, dispels the cause of disease, reaches and thoroughly cures disease, the treatment mesh no longer recurred
's.
6. the present invention can lift body's immunity, and improve growth conditions while disease is cured.
7. the present invention can increase the gastrointestinal motility ability of poultry, increase poultry feed intake, lift feed conversion rate.
8. the present invention is optimized according to birds food feature, easy to use using drinking water administration mode.
9. the present invention can suppress the growth and breeding of pathogen, pathogenic bacteria, toxin are reduced to gastrointestinal irritation, promotes intestines and stomach to glue
The reparation of film.
(4) embodiment
In order to be better understood from and implement the present invention, the present invention is further illustrated with reference to specific embodiment.
1. prescription medicine compliance test result test.
Embodiment 1 is a preferred embodiment of the present invention, and each raw material is calculated by weight in Chinese medicine composition：Honeysuckle 15
Part, 15 parts of the Radix Astragali, 30 parts of the root of kudzu vine, 25 parts of radix glycyrrhizae, 10 parts of dried orange peel, 15 parts of cape jasmine, 15 parts of corydalis tuber.
Comparative example 1-4 is chooses conventional antiulcer and anti-inflammatory drug, as obtained by random combine.
Comparative example 5 comes from granted patent《A kind of Chinese medicine preparation for preventing and treating poultry proventriculitis ventriculitis》(patent application
Number：201310513889.9) compositing formula.
Medicine is constituted by weight ratio in embodiment 1, comparative example 1-5, such as table 1 below.
Table 1 be grouped and prescription in medicine constitute
The preparation method of embodiment 1 and comparative example 1-4 Chinese medicine composition：(1) the weight relation is pressed
Medicinal material is weighed, medicinal material is distinguished into impurity elimination, is weighed, is cleaned, the coarse powder for being made that particle diameter is 180 μm~600 μm is crushed, is added after merging
The water of 4 times of weight, soaks 2h；(2) medicinal material and soak after immersion are added after purified water to 12 times of medicinal material weight, entered
Row ultrasonic extraction；(3) merge herbal extract, carry out decoction concentration using negative pressure of vacuum method for concentration, be concentrated into medicinal material amount
After 2 times, pour out, herbal extract is stood into 24h in Cool Room 4 DEG C；(4) 4 DEG C of standing 24h herbal extract is taken out, with
12000rpm carries out online high speed centrifugation；(5) pH value range of centrifugate is adjusted to after 5, it is micro- using 0.22 μm~0.45 μm
Hole filter membrane is filtered, and collects filtered solution, is added auxiliary material and is prepared, and filling, sterilizing is carried out after preparation, is got product.
Comparative example 5 is with reference to granted patent《A kind of Chinese medicine preparation for preventing and treating poultry proventriculitis ventriculitis》(patent application
Number：201310513889.9) compositing formula, weighs cuttlebone 12, golden cypress 8, rheum officinale 6, the bark of ash 8 by weight, Radix Codonopsis 10,
The Chinese bulbul 34, the bighead atractylodes rhizome 10, Poria cocos 9, radix glycyrrhizae 3, are processed into pulvis, produce.
Clinical test 1
Tangshan 13 aa broiler chickens of a certain feeding chicken in largely scale occur feed intake and declined, and feed occurs in growth retardation
Just, occur compared with high mortality.Found after dissecting diseased chicken, glandular stomach swelling is serious, glandular stomach nipple severe haemorrhage.With reference to prevalence
Disease is learned, clinical symptoms and diseased chicken cut open inspection situation are diagnosed as broiler chicken proventriculitis ventriculitis.
1600 morbidity chickens are randomly selected, approximate according to body weight, the approximate principle of illness degree is randomly divided into 8 groups, every group
200 chickens.Embodiment 1 and comparative example 1-4 are mixed in drinking-water according to the ratio in 0.2% (v/v), allow chicken freely to drink
With being used in conjunction 5 days.Comparative example 5 allows chicken free choice feeding according to 0.1% (w/w) ratio uniform spice, is used in conjunction 5 days.It is positive
Control group is treated using 10% amoxicillin soluble powder, and consumption is to add 600mg per in 1L water, continuous to use 5 days.
Blank control group not medication.After medication 5 days, with death and culling rate, Average weight increasing a day, glandular stomach muscular stomach degree of injury, efficient and cure rate
For inspection target, therapeutic effect is counted, statistical analysis is carried out using SAS9.0 softwares.
Curative effect determinate standard is as follows：
Cure rate：After the completion of experiment, feed intake, amount of drinking water, every clinical symptoms such as the state of mind are recovered to normal water
The ratio of this group of chicken number shared by flat diseased chicken.
It is efficient：After the completion of experiment, feed intake, amount of drinking water, the disease that every clinical symptoms such as the state of mind have taken a turn for the better
The ratio of this group of chicken number shared by chicken.
Death and culling rate：Dead during experiment, medication loses the ratio of this group of chicken number shared by the diseased chicken of symptom improvement.
The result of the test of each group treatment is shown in Table 2.
The each group therapeutic effect of table 2
| Packet | Case load (only) | Glandular stomach muscular stomach degree of injury | Average weight increasing a day (g) | Death and culling rate | Cure rate | It is efficient |
| Embodiment 1 | 200 | - | 75±9.32A | 3% | 86.5% | 97% |
| Comparative example 1 | 200 | ++ | 22±3.99D | 14% | 67% | 86% |
| Comparative example 2 | 200 | ++ | 17±4.48E | 16.5% | 61 | 83.5% |
| Comparative example 3 | 200 | + | 31±7.21C | 15.5% | 72% | 84.5% |
| Comparative example 4 | 200 | ++ | 36±3.16C | 18% | 62.5% | 82% |
| Comparative example 5 | 200 | ++ | 43±5.80B | 21% | 53% | 79% |
| Positive controls | 200 | + | 52±3.26B | 10.5% | 79% | 89.5% |
| Blank control group | 200 | ++ | 8±0.74F | 27% | — | — |
Note：Alphabetical different expression differences are extremely significantly (P ＜ 0.01)."-" glandular stomach not damaged；The damage of "+" glandular stomach is obvious；“++”
Glandular stomach damage is serious.
Result of the test shows that embodiment 1 extremely significantly reduces the death and culling rate (P ＜ 0.01) of morbidity chicken, extremely significantly carried
Cure rate and effective percentage (P ＜ 0.01) are risen, pole is a significant increase Average weight increasing a day (P ＜ 0.01), has reversed growth inhibiting
State, and significantly alleviate the degree of injury of muscular stomach glandular stomach.
Result of the test shows, the prescription in the embodiment of the present invention 1 and random selection are with promoting the circulation of qi tonifying Qi, clearing heat and detoxicating, anti-
The combination of scorching and medicament for anti-gastric ulcer compares, with significantly superior effect；With granted patent《One kind preventing and treating poultry proventriculitis flesh
The Chinese medicine preparation of gastritis》(number of patent application：201310513889.9) Chinese medicine preparation announced compares, also with significant
Clinical efficacy, while the short physiological characteristic of oral liquid poultry alimentary canal more preferably than pulvis is also further demonstrate, it is especially right
For the symptom that feed intake is remarkably decreased when poultry falls ill, oral liquid treatment is better.
2. prescription medicine ratio optimization and compliance test result test
In order to which whether the various drug ratio relations determined in embodiment 1 are optimal cases, therefore of the present invention group is carried out
The screening of drug dose in compound, specific usage ratio is as shown in table 3 below, table 4.
The embodiment 1-7 components by weight percent ratios of table 3
The comparative example composition by weight ratio of table 4
The preparation method of embodiment 1-6 and comparative example 6-12 Chinese medicine composition：(1) closed by the weight
System weighs medicinal material, and medicinal material is distinguished into impurity elimination, weighed, and cleans, and crushes the coarse powder for being made that particle diameter is 180 μm~600 μm, adds after merging
Enter the water of 4 times of weight, soak 2h；(2) medicinal material and soak after immersion are added after purified water to 12 times of medicinal material weight, entered
Row ultrasonic extraction；(3) merge herbal extract, carry out decoction concentration using negative pressure of vacuum method for concentration, be concentrated into the 2 of medicinal material amount
After times, pour out, herbal extract is stood into 24h in Cool Room 4 DEG C；(4) 4 DEG C of standing 24h herbal extract is taken out, with
12000rpm carries out online high speed centrifugation；(5) pH value range of centrifugate is adjusted to after 5, it is micro- using 0.22 μm~0.45 μm
Hole filter membrane is filtered, and collects filtered solution, is added auxiliary material and is prepared, and filling, sterilizing is carried out after preparation, is got product.
Clinical test 2
It is continuing with plant in clinical test 1 and has made a definite diagnosis the AA broiler chicken for occurring glandular stomach ventriculitis, randomly selects 2800
Fall ill chicken, and approximate according to body weight, the approximate principle of illness degree is randomly divided into 14 groups, every group of 200 chickens.Embodiment 1-6 according to
Mixed in 0.2% (v/v) ratio in drinking-water, allow chicken freely to drink, be used in conjunction 5 days.Blank control group not medication.Medication 5 days
Afterwards, with death and culling rate, Average weight increasing a day, glandular stomach muscular stomach degree of injury, efficient and cure rate are inspection target, count therapeutic effect,
Statistical analysis is carried out using SAS9.0 softwares.Evaluation index is shown in Table 5 with clinical test 1, the result of the test of each group treatment.
The each group therapeutic effect of table 5
| Packet | Case load (only) | Glandular stomach muscular stomach degree of injury | Average weight increasing a day (g) | Death and culling rate | Cure rate | It is efficient |
| Embodiment 1 | 200 | - | 72±6.56B | 3% | 86.5% | 97% |
| Embodiment 2 | 200 | - | 67±4.27B | 3.5% | 85.5% | 96.5% |
| Embodiment 3 | 200 | - | 68±2.95B | 1.5% | 90.5% | 98.5% |
| Embodiment 4 | 200 | - | 80±5.93A | 0.5% | 95% | 99.5% |
| Embodiment 5 | 200 | - | 69±3.13B | 1.5% | 90.5% | 98.5% |
| Embodiment 6 | 200 | - | 64±2.38C | 4% | 83% | 96% |
| Comparative example 6 | 200 | + | 62±1.33C | 5% | 82.5% | 95% |
| Comparative example 7 | 200 | + | 60±2.46C | 6.5% | 80.5% | 93.5% |
| Comparative example 8 | 200 | + | 52±1.74D | 9% | 79% | 91% |
| Comparative example 9 | 200 | + | 51±3.25D | 10% | 78% | 90% |
| Comparative example 10 | 200 | + | 62±4.31C | 5.5% | 83.5% | 94.5% |
| Comparative example 11 | 200 | + | 57±2.42D | 7% | 80% | 93% |
| Comparative example 12 | 200 | + | 59±3.57C | 6% | 81.5% | 94% |
| Blank control group | 200 | ++ | 12±0.59E | 25% | — | — |
Note：Alphabetical different expression differences are extremely significantly (P ＜ 0.01)."-" glandular stomach not damaged；The damage of "+" glandular stomach is obvious；“++”
Glandular stomach damage is serious.
Result of the test is shown, death and culling rate, lifting cure rate and effective percentage can be reduced after embodiment 1-6 uses, improves life
Long holddown, wherein embodiment 4 are preferred plan.Embodiment 4 extremely significantly reduces death and culling rate (the P ＜ of morbidity chicken
0.01), pole has been obviously improved cure rate and effective percentage (P ＜ 0.01), and pole is a significant increase Average weight increasing a day (P ＜ 0.01),
Growth inhibiting state has been reversed, and has significantly alleviated the degree of injury of glandular stomach muscular stomach.
By embodiment 1-6 and comparative example 6-12 results showed thats when honeysuckle, the Radix Astragali, the root of kudzu vine, radix glycyrrhizae, dried orange peel,
The oral liquid that cape jasmine and corydalis tuber are prepared from after being combined with specific ratio quantity can significantly mitigate poultry proventriculitis flesh
The lesion and damage degree of gastritis, and growth inhibition state is significantly improved, and also cure rate is compared with comparative example,
With extremely significant difference.The medicine of this non-combination and ratio has larger otherness with this composition of medicine.
3. optimal prescription (embodiment 4) is in other regional compliance test result tests
Drug ratio to verify preferred scheme embodiment 4 has carried out clinical examination in the Clinical practice effect of different regions
Test 3-5.
Clinical test 3
3 hen houses of a certain feeding chicken in largely scale in Hebei province Qinhuangdao, more than totally 11000 only 19 aa broiler chickens search for food
Amount declines, growth retardation, and feed just, occurs compared with high mortality.Found after dissecting diseased chicken, glandular stomach swelling is serious, glandular stomach
Nipple severe haemorrhage.Broiler chicken proventriculitis ventriculitis is diagnosed as with reference to epidemiology, clinical symptoms and diseased chicken cut open inspection situation.
4 groups of embodiment, control group 1 and control group 2 are used as using 3 hen houses are random.4 groups of embodiment in embodiment 4 using carrying
Take the traditional Chinese medicine oral liquid of preparation；Control group 1 is using glandular stomach health (10% amoxicillin soluble powder), and consumption is to be added per in 1L water
600mg, it is continuous to use 5 days；Control group 2 is treated using Cimetidine, and consumption is to add 1g per in 10kg feeds, is continuously made
With 5 days.Treatment results are as follows：
The each group therapeutic effect of table 6
| Group | Sum | Glandular stomach degree of injury | Daily gain (g) | Death and culling rate |
| 4 groups of embodiment | 3635 | - | 82±3.11A | 0.58% |
| Control group 1 | 3940 | ++ | 10±0.57C | 9.15% |
| Control group 2 | 3841 | ++ | 20±0.38B | 8.33% |
Note：Alphabetical different expression differences are extremely significantly (P ＜ 0.01)；"-" glandular stomach not damaged；The damage of "+" glandular stomach is obvious；“++”
Glandular stomach damage is serious.
Embodiment 4 is substantially mitigated using symptom after 1 day, and feeding recovers, and after 3 days, feed intake has recovered normal, spirit
In good condition, there is proventriculitis symptom in small part, after 5 days, all cure.
Symptom after 3 days, has part chicken symptom to alleviate, after 5 days still without significant change after control group 1-2 medications 1 day
So with the presence of more chicken proventriculitis symptom, and the death rate is higher.
Result of the test shows that present invention treatment chicken proventriculitis ventriculitis has preferable therapeutic effect, and better than A Moxi
Woods soluble powder and Cimetidine.
Clinical test 4
There is feed intake decline in 5000 21 aa broiler chickens of a certain feeding chicken in largely scale in Daliang City of Liaoning Province, feed just,
Occur compared with high mortality.Found after dissecting diseased chicken, glandular stomach swelling is serious, glandular stomach nipple severe haemorrhage.With reference to epidemic disease
Learn, clinical symptoms and diseased chicken cut open inspection situation are diagnosed as broiler chicken proventriculitis ventriculitis.It is random that chicken group is divided into 2 groups, every group 2500,
One group is treatment group, and mixed drink is carried out using the oral liquid prepared by the embodiment of the present invention 4；Another group is control group, using 10%
Amoxicillin soluble powder is treated.Comparing result is as follows after 5 days：
The each group therapeutic effect of table 7
| Group | Glandular stomach muscular stomach degree of injury | Daily gain (g) | Death and culling rate |
| 4 groups of embodiment | - | 78±2.01A | 0.52% |
| Control group | ++ | 34±1.86B | 8.91% |
Note：Alphabetical different expression differences are extremely significantly (P ＜ 0.01)；"-" glandular stomach not damaged；The damage of "+" glandular stomach is obvious；“++”
Glandular stomach damage is serious.
Embodiment 4 is substantially mitigated using symptom after 1 day, and feeding recovers, after 2 days, and feed intake recovers normal, spiritual shape
State is good, partly there is proventriculitis symptom, after 4 days, all cures.
Symptom is without significant change after 1 day for control group medicine, after 4 days, has part chicken symptom to alleviate, still has after 5 days
There is proventriculitis symptom in more chicken, and the death rate is higher.
Result of the test shows that present invention treatment chicken proventriculitis ventriculitis has preferable therapeutic effect, and better than A Moxi
Woods soluble powder.
Clinical test 5
Only there is feed intake decline to a certain feeding chicken in largely scale more than 8000 in level in Anshan city, liaoning province in 16 aa broiler chickens, and feed is just
Situations such as, while occurring compared with high mortality.Found after dissecting diseased chicken and chicken of being at death's door, glandular stomach swelling is serious, glandular stomach
Nipple severe haemorrhage.Broiler chicken proventriculitis ventriculitis is diagnosed as with reference to epidemiology, clinical symptoms and diseased chicken cut open inspection situation.At random will
Chicken group is divided into 4 groups of embodiment and control group.4 groups of embodiment is treated using the traditional Chinese medicine oral liquid that preparation is extracted in embodiment 4,
It is continuous to use 5 days；Control group is treated using 10% amoxicillin soluble powder, and (consumption is to add 600mg per in 1L water, even
It is continuous to use 5 days), treatment results are as follows：
The each group therapeutic effect of table 8
| Group | Sum | Glandular stomach muscular stomach degree of injury | Daily gain (g) | Death and culling rate |
| 4 groups of embodiment | 4133 | - | 85±4.77A | 0.48% |
| Control group | 4095 | ++ | 28±4.19B | 9.26% |
Note：Alphabetical different expression differences are extremely significantly (P ＜ 0.01)；"-" glandular stomach not damaged；The damage of "+" glandular stomach is obvious；“++”
Glandular stomach damage is serious.
4 groups of embodiment is substantially mitigated using symptom after 1 day, and feeding recovers, after 2 days, and feed intake recovers normal, spirit
It is in good condition, partly there is proventriculitis symptom, after 4 days, all cure.
Symptom after 4 days, has part chicken symptom to alleviate, after 5 days still without significant change after control group medication 1 day
With the presence of more chicken proventriculitis symptom, and the death rate is higher.
Result of the test shows that present invention treatment chicken proventriculitis ventriculitis has preferable therapeutic effect, and pole is significantly better than
Amoxicillin soluble powder.
Where the advantage that the general principle for illustrating the present invention, technical characteristics and the present invention are shown and described above.
The technical staff of the industry is described in above-described embodiment and specification it is to be appreciated that the present invention is not limited to the above embodiments
Simply to illustrate that the present invention principle, without departing from the spirit and scope of the present invention, the present invention also have it is various
Changes and improvements, these changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by institute
Attached claims and its equivalent thereof.
Claims (10)
1. a kind of Chinese medicine composition for preventing and treating poultry proventriculitis ventriculitis, it is characterised in that：The Chinese medicine composition is by following weight
The Chinese medicine composition of part：10~20 parts of honeysuckle, 10~20 parts of the Radix Astragali, 25~40 parts of the root of kudzu vine, 15~35 parts of radix glycyrrhizae, dried orange peel 5~
15 parts, 10~20 parts of cape jasmine, 10~20 parts of corydalis tuber.
2. the Chinese medicine composition of preventing and treating poultry proventriculitis ventriculitis according to claim 1, it is characterised in that：The Chinese medicine group
Compound is made up of the Chinese medicine of following parts by weight：10~15 parts of honeysuckle, 10~15 parts of the Radix Astragali, 25~30 parts of the root of kudzu vine, radix glycyrrhizae 15
~25 parts, 5~10 parts of dried orange peel, 10~15 parts of cape jasmine, 10~15 parts of corydalis tuber.
3. the Chinese medicine composition of preventing and treating poultry proventriculitis ventriculitis according to claim 2, it is characterised in that：The Chinese medicine group
Compound is made up of the Chinese medicine of following parts by weight：10 parts of honeysuckle, 10 parts of the Radix Astragali, 25 parts of the root of kudzu vine, 15 parts of radix glycyrrhizae, 5 parts of dried orange peel, Cape jasmine
10 parts of son, 10 parts of corydalis tuber.
4. the Chinese medicine composition of preventing and treating poultry proventriculitis ventriculitis according to claim 2, it is characterised in that：The Chinese medicine group
Compound is made up of the Chinese medicine of following parts by weight：14 parts of honeysuckle, 14 parts of the Radix Astragali, 26 parts of the root of kudzu vine, 20 parts of radix glycyrrhizae, 7 parts of dried orange peel, Cape jasmine
14 parts of son, 12 parts of corydalis tuber.
5. the Chinese medicine composition of preventing and treating poultry proventriculitis ventriculitis according to claim 2, it is characterised in that：The Chinese medicine group
Compound is made up of the Chinese medicine of following parts by weight：15 parts of honeysuckle, 15 parts of the Radix Astragali, 30 parts of the root of kudzu vine, 25 parts of radix glycyrrhizae, 10 parts of dried orange peel,
15 parts of cape jasmine, 15 parts of corydalis tuber.
6. the Chinese medicine composition described in any one of Claims 1 to 5 is preparing medicine, the feed of preventing and treating poultry proventriculitis ventriculitis
Or the application in feed addictive.
7. a kind of preparation method of the Chinese medicine composition of the preventing and treating poultry proventriculitis ventriculitis described in any one of Claims 1 to 5,
It is characterized in that：Comprise the following steps：
(1) the taste medicinal material of honeysuckle, the Radix Astragali, the root of kudzu vine, radix glycyrrhizae, dried orange peel, cape jasmine and corydalis tuber etc. 7 is distinguished into impurity elimination, weighed, cleaned,
The coarse powder for being made that particle diameter is 180 μm~600 μm is crushed, the water of 3~5 times of weight is added after merging, 1h-3h is soaked；
(2) medicinal material and soak after immersion are added after purified water to 10~15 times of medicinal material weight, carries out ultrasonic extraction；
(3) merge herbal extract, carry out decoction concentration using negative pressure of vacuum method for concentration, be concentrated into 1~3 times of medicinal material amount
Afterwards, pour out, herbal extract is stood into 24h in Cool Room 4 DEG C；
(4) 4 DEG C of standing 24h herbal extract is taken out, online high speed centrifugation is carried out with 10000rpm~16000rpm；
(5) pH value range of centrifugate is adjusted to after 4~6, filtered using miillpore filter, collect filtered solution, added auxiliary
Material is prepared, and filling, sterilizing is carried out after preparation, is produced.
8. the preparation method of the Chinese medicine composition of preventing and treating poultry proventriculitis ventriculitis according to claim 7, its feature exists
In：Ultrasonic extraction power is 25kHz~50kHz in the step (2), and Extracting temperature is 80 DEG C~100 DEG C, and extraction time is
0.5h~1.5h, extraction time is 1~3 time；The vacuum that negative pressure of vacuum is concentrated in step (3) is -0.06Mpa~-0.1Mpa,
Temperature is 80 DEG C~90 DEG C；The pore size of miillpore filter is 0.22 μm~0.45 μm in step (5).
9. the preparation method of the Chinese medicine composition of the preventing and treating poultry proventriculitis ventriculitis according to any one of claim 7~8,
It is characterized in that：Optionally, corresponding auxiliary material is added, the finished product preparation of medicine, feed or feed addictive can be further made.
10. the preparation method of the Chinese medicine composition of preventing and treating poultry proventriculitis ventriculitis according to claim 9, its feature exists
In：The formulation of the finished product preparation being made includes oral liquid, pulvis, granule, powder, Ultramicro-powder, injection, tablet, soup
Agent, pill.
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| CN110302276A (en) * | 2019-07-12 | 2019-10-08 | 北京生泰尔科技股份有限公司 | It is a kind of for preventing and treating the Chinese medicine composition and preparation method thereof of chicken pneumonia |
| CN112616777A (en) * | 2021-01-20 | 2021-04-09 | 山东省农业科学院家禽研究所（山东省无特定病原鸡研究中心） | Method for quickly constructing chicken glandular myositis model |
| CN115517321A (en) * | 2021-05-25 | 2022-12-27 | 山东德聚仁合生物工程有限公司 | Preparation method for improving proventriculitis and muscular gastritis of poultry by using natural feed raw materials |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302276A (en) * | 2019-07-12 | 2019-10-08 | 北京生泰尔科技股份有限公司 | It is a kind of for preventing and treating the Chinese medicine composition and preparation method thereof of chicken pneumonia |
| CN112616777A (en) * | 2021-01-20 | 2021-04-09 | 山东省农业科学院家禽研究所（山东省无特定病原鸡研究中心） | Method for quickly constructing chicken glandular myositis model |
| CN112616777B (en) * | 2021-01-20 | 2022-04-19 | 山东省农业科学院家禽研究所（山东省无特定病原鸡研究中心） | Method for quickly constructing chicken glandular myositis model |
| CN115517321A (en) * | 2021-05-25 | 2022-12-27 | 山东德聚仁合生物工程有限公司 | Preparation method for improving proventriculitis and muscular gastritis of poultry by using natural feed raw materials |
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