CN104739960B - Stomach antibacterial combination, the stomach antibacterials containing said composition and preparation - Google Patents
Stomach antibacterial combination, the stomach antibacterials containing said composition and preparation Download PDFInfo
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- CN104739960B CN104739960B CN201310729624.2A CN201310729624A CN104739960B CN 104739960 B CN104739960 B CN 104739960B CN 201310729624 A CN201310729624 A CN 201310729624A CN 104739960 B CN104739960 B CN 104739960B
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Abstract
The present invention relates to a kind of stomach antibacterial combination, the stomach antibacterials containing said composition and its preparation.Described pharmaceutical composition is by 100~300 parts of the coptis（Weight）, 50~150 parts of rheum officinale（Weight）, 50~150 parts（Weight）Composition.The stomach antibacterials are made of pharmaceutical adjuvants such as aforementioned pharmaceutical compositions and pharmaceutically acceptable carriers.The stomach antibacterials by be by the coptis, rheum officinale and 3 taste Chinese medicine of radix glycyrrhizae is extracted be processed into medicinal extract after, be mixed according to a certain percentage with pharmaceutical adjuvant.The stomach antibacterial combination and stomach antibacterials of the present invention simplifies existing four yellow Zhili granule prescriptions, reduces production cost, and clinical efficacy is good.It is suitable with existing four yellow Zhili granule therapeutic effects that stomach antibacterial medicine preparation is made in stomach antibacterial combination.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, is related to a kind of stomach antibacterial combination, the stomach antibacterial containing said composition
Medicine and its preparation.
Background technology
A kind of preparation for the treatment for being conventionally used to damp-heat dysentery and chicken colibacillosis is four yellow Zhili granules, said preparation by
The coptis, Cortex Phellodendri, rheum officinale, radix scutellariae, Radix Isatidis, 6 taste Chinese medicine of radix glycyrrhizae is extracted be processed into medicinal extract after, with sucrose, dextrin by certain
The particle that ratio is mixed, has effects that clearing heat-fire, stop dysentery, and clinic is mainly used for damp-heat dysentery and chicken colibacillosis
Treatment, damp and hot rushed down as caused by the Escherichia coli of chicken, Pasteurella, Salmonella infection and viral disease scabies secondary infection
Dysentery, dysentery characterized by white mucous stool, yellow-white dysentery, water sample rush down dysentery etc.；Diarrhea, yellowish-white dysentery, infectiousness intestines caused by swine escherichia coli, Salmonella
Spurting watery diarrhea etc. caused by the viral diseases such as gastritis, epidemic diarrhea, rotavirus diarrhea.Because its it is definite the effect of
And good reputation, successively it is included in 2005 editions, 2010 editions Republic of China Veterinary Pharmacopoeia.But four yellow Zhili granule components
Complexity, non-principal component is more, and quality is difficult to control, and limits the application of four yellow Zhili granules clinically to a certain extent.
Chinese patent CN102008585B discloses yellow stop dysentery effervescence granular of one kind four and preparation method thereof, by following weight
The raw material and auxiliary material of part are prepared：The coptis 200, Cortex Phellodendri 200, rheum officinale 100, radix scutellariae 200, Radix Isatidis 200, radix glycyrrhizae 100, carbonic acid
Hydrogen sodium 108~132, fumaric acid 90~110, diluent 549~671, flavouring 18~22.Separately pelletized using soda acid at the same time
Method prepares effervescence granular.For the present invention using sodium acid carbonate as alkaline agent, fumaric acid adds other auxiliary materials as acidizer
Supplementary product consumption can be reduced by preparing four yellow stop dysentery effervescence granulars, and preparation process is simple, easily molded, not easy to moisture absorption, and rate of effervescence is fast, bubble
It is good to rise effect, melting is good, after effervesce liquid clarity it is good, without breeze foreign matter etc..Said preparation there is also complicated component, it is unknown into
Divide more, quality problem rambunctious.
Therefore, the problem of presently, there are is to need to research and develop a kind of composition simply, and quality is easily controllable, and eutherapeutic
Stomach antibiotic preparation.
The content of the invention
The technical problems to be solved by the invention are in view of the deficiencies of the prior art, there is provided a kind of stomach antibacterials combination
Thing, it is made of the coptis, rheum officinale and 3 taste Chinese medicine of radix glycyrrhizae.Present invention also offers a kind of stomach antibacterials, it is by said medicine
The pharmaceutical adjuvant such as composition and pharmaceutically acceptable carrier forms.The stomach antibacterials are by 3 taste of the coptis, rheum officinale and radix glycyrrhizae
Chinese medicine is extracted be processed into medicinal extract after, be mixed according to a certain percentage with pharmaceutical adjuvant.The stomach antibacterials group of the present invention
Compound and stomach antibacterials simplify existing four yellow Zhili granule prescriptions, reduce production cost, and clinical efficacy is good.
For this reason, first aspect present invention provides a kind of stomach antibacterial combination, in parts by weight, by following components
Composition：
100~300 parts of the coptis,
50~150 parts of rheum officinale, and
50~150 parts of radix glycyrrhizae.
Second aspect of the present invention provides a kind of stomach antibacterials, its medicine group provided by first aspect present invention
Compound and pharmaceutical adjuvant composition, wherein, the pharmaceutical adjuvant includes 200~300 parts pharmaceutically acceptable by weight
Carrier.
According to the present invention, the pharmaceutically acceptable carrier includes soluble starch, dextrin, glucose or sucrose.
In one embodiment of the invention, the pharmaceutical adjuvant further includes and is calculated as 8~12 parts of saccharin sodium by weight.
In another embodiment of the present invention, the stomach antibacterials are graininess.
Third aspect of the present invention provides a kind of stomach antibacterials according to second aspect of the right present invention
Preparation method, it includes：
Step A, prepares the coptis-rheum officinale-licorice root ointment：Soak the coptis, rheum officinale, radix glycyrrhizae and carry out first time decoction, so
After filter, obtain the coptis, rheum officinale, radix glycyrrhizae mixing decoction liquor I, into the remaining dregs of a decoction plus water and carry out second and decoct, then mistake
Filter, obtains the coptis, rheum officinale, radix glycyrrhizae mixing decoction liquor II, merges mixing decoction liquor I and II, filter, stand, supernatant is depressurized
Concentration, to obtain the final product；
Step B, prepares stomach antibacterials：Pharmaceutical adjuvant is added into the coptis-rheum officinale-extract of licorice root, it is spray-dried
Granulation, sieving, to obtain the final product.
According to the present invention, the coptis-relative density of the rheum officinale-extract of licorice root under the conditions of 20 DEG C is 1.32~1.35.
In the specific embodiment of the present invention, in step, according to 8 times of the coptis, rheum officinale and radix glycyrrhizae gross weight
The coptis, rheum officinale, radix glycyrrhizae 4h are soaked, carries out first time decoction, filtering, obtains the coptis, rheum officinale, radix glycyrrhizae mixing decoction liquor I, press
1h is added water to cook according to 8 times of remaining dregs of a decoction weight, is filtered, the coptis, rheum officinale, radix glycyrrhizae mixing decoction liquor II is obtained, merges mixing and decoct
Boil liquid I and II, is filtered, and stands, supernatant is concentrated under reduced pressure, and the coptis-rheum officinale-licorice root ointment is made.
In the another embodiment of the present invention, in stepb, pharmacy is added into the coptis-rheum officinale-licorice root ointment
Upper acceptable carrier and saccharin sodium, spray-dried granulation, crosses 16 mesh sieves, and stomach antibacterials are made.
It is prepared by the pharmaceutical composition that the 4th aspect of the present invention is provided described in a kind of the first aspect according to the present invention
The application in medicine for treating damp-heat dysentery and chicken colibacillosis.
Heretofore described term " medicinal extract " refers to extract of the Chinese medicine extract after concentration, because being cream
Shape, so being medicinal extract.
Heretofore described term " decoction " refers to the method for atmospheric boiling extraction traditional Chinese medicine ingredients.
Stomach antibacterial combination provided by the present invention is made of the coptis, rheum officinale and 3 taste Chinese medicine of radix glycyrrhizae.The present invention's
The pharmaceutical adjuvant such as stomach antibacterials pharmaceutical composition provided by the present invention and pharmaceutically acceptable carrier forms.The stomach
Antibacterials be by the coptis, rheum officinale and 3 taste Chinese medicine of radix glycyrrhizae is extracted be processed into medicinal extract after, mixed according to a certain percentage with pharmaceutical adjuvant
Conjunction is made.The stomach antibacterial combination and stomach antibacterials of the present invention simplifies existing four yellow Zhili granule prescriptions,
Production cost is reduced, and clinical efficacy is good.By stomach antibacterial combination be made stomach antibacterial medicine preparation with it is existing
Four yellow Zhili granule therapeutic effects are suitable.
Embodiment
To make the present invention easier to understand, below in conjunction with embodiment, the present invention will be described in detail, these embodiments are only
Serve illustrative, it is not limited to application range of the invention, unmentioned specific experiment method in the following example, usually
Carried out according to normal experiment method.
The coptis, rheum officinale, licorice medicinal materials and saccharin sodium source used in the embodiment of the present invention：The coptis, rheum officinale, radix glycyrrhizae, are purchased from Bo
Thousand herbal medicine industry medicine materical crude slice factory of state；Saccharin sodium, content 99.1%, Zhengzhou Jingde chemical products Co., Ltd.Embodiment
Embodiment 1：
A kind of Chinese medicine compound prescription antimicrobial, includes the component of following parts by weight：The coptis 200, rheum officinale 100, radix glycyrrhizae 100 can
Soluble starch 250g.Its preparation method is as follows：
1st, the 200g coptiss, 100g rheum officinales, 100g radix glycyrrhizaes are weighed, soaks 4h by the water of 8 times of amount medicinal material weight, heating decocts,
First time 2h, the water that second of dregs of a decoction adds 8 times of amount medicinal material weight decoct 1h, merge decoction liquor, filter, stands, take supernatant
Relative density is 1.32~1.35 thick paste when being concentrated under reduced pressure into 20 DEG C.
2nd, added into thick paste, 250g soluble starches, spray-dried granulation, cross 16 mesh sieves, to obtain the final product.
Embodiment 2：
A kind of Chinese medicine compound prescription antimicrobial, includes the component of following parts by weight：The coptis 100, rheum officinale 50, radix glycyrrhizae 50, grape
Sugar 200.Its preparation method is as follows：
1st, the 100g coptiss, 50g rheum officinales, 50g radix glycyrrhizaes are weighed, soaks 4h by the water of 8 times of amount medicinal material weight, heating decocts, the
2h, the water that second of dregs of a decoction adds 8 times of amount medicinal material weight decoct 1h, merge decoction liquor, filter, stands, take supernatant to subtract
Relative density is 1.32~1.35 thick paste when pressure is concentrated into 20 DEG C.
2nd, 200g glucose is added into thick paste, spray-dried granulation, crosses 16 mesh sieves, to obtain the final product.
Embodiment 3：
A kind of Chinese medicine compound prescription antimicrobial, includes the component of following parts by weight：The coptis 300, rheum officinale 150, radix glycyrrhizae 150, paste
Essence 100, sucrose 200g.Its preparation method is as follows：
1st, the 300g coptiss, 150g rheum officinales, 150g radix glycyrrhizaes are weighed, soaks 4h by the water of 8 times of amount medicinal material weight, heating decocts,
First time 2h, the water that second of dregs of a decoction adds 8 times of amount medicinal material weight decoct 1h, merge decoction liquor, filter, stands, take supernatant
Relative density is 1.32~1.35 thick paste when being concentrated under reduced pressure into 20 DEG C.
2nd, added into thick paste, 300g dextrin, sucrose 200g, spray-dried granulation, cross 16 mesh sieves, to obtain the final product.
Embodiment 4：Clinical effect trial of the Chinese medicine compound prescription antimicrobial to artificial challenge's colibacillosis
Control drug：Four yellow granulation particles, self-control.
Four yellow Zhili granule preparation methods：
（1）Coptis 200g, Cortex Phellodendri 200g, rheum officinale 100g, radix scutellariae 200g, Radix Isatidis 200g, radix glycyrrhizae 100g are weighed respectively, are added
Enter into 8000ml purified waters and soak 4h, decoct 2 times, first time 2h, second of dregs of a decoction adds the purifying decocting of 8 times of medicinal material weight
1h is boiled, merges decoction liquor, is filtered, is stood, takes supernatant to be concentrated under reduced pressure into the thick paste that relative density is 1.31~1.35.
（2）Dextrin, the sucrose of 25% thick paste quality of 2 times of thick paste quality are added in thick paste, is uniformly mixed, is made softwood, 16
Mesh sieve is pelletized, dry under the conditions of 70~80 DEG C, whole grain, to obtain the final product.
20 age in days SPF chickens 180 are chosen, are randomly divided into 6 groups, every group 30, every group is weighed.The packet of experimental animal and
Dosage regimen is shown in Table 1.
Table 1
| Group | Number of animals/only | First weight/g | Dosage regimen |
| 1st group：Embodiment 1 | 30 | 191.4 | Infection, 1mg/ml concentrate drinking-water, 5d are used in conjunction |
| 2nd group：Embodiment 2 | 30 | 178.9 | Infection, 1mg/ml concentrate drinking-water, 5d are used in conjunction |
| 3rd group：Embodiment 3 | 30 | 184.2 | Infection, 1mg/ml concentrate drinking-water, 5d are used in conjunction |
| 4th group：Drug control group | 30 | 176.5 | Infection, 1mg/ml concentrate drinking-water, 5d are used in conjunction |
| 5th group：Positive controls | 30 | 185.2 | Infection, is not administered |
| 6th group：Healthy control group | 30 | 187.8 | Do not infect, be not administered |
Escherichia coli are subcutaneously injected in 1st~5 group of chicken neck（ChickenE coliO2 reference culture, Chinese veterinary medicament prison
Examine and provided）Nutrient solution（5 × 108CFU/ml of bacterial concentration）0.5ml.1st~4 group start when occurring symptom after attacking poison to
Medicine, prohibits water 2h, 5d is used in conjunction before medication.The clinical symptoms such as each group chicken state of mind, appetite, breathing are observed daily after attacking poison, and
Record morbidity and death condition, dissect are died of illness chicken, are observed lesion degree, are made bacteria distribution culture, determine the cause of the death, continue after drug withdrawal
Observation 14 days.
Index of assessment of curative effect is as follows：
Cure：During experiment, after drinking water administration, Escherichia coli disease symptoms fade away, the state of mind, appetite, breathing etc.
Recover normal.Cure rate=healing chicken number/morbidity chicken number.
Effectively：During experiment, after drinking water administration, the symptom such as diarrhea mitigates, and the state of mind, appetite, breathing etc. progressively recover
Normally.Efficient=effective chicken number/morbidity chicken number.
It is dead：Occur Escherichia coli disease symptoms during experiment and death, dissect have typical characteristics of lesion, pathological material of disease can separate
Go out Escherichia coli, be judged to infecting bacterium death.The death rate=death chicken number/test chicken number.
Weightening：On-test and at the end of weigh chicken weight respectively, calculate average weight gain and body weight increase rate.With health
Average weight gain of the control group chicken during experiment is 100%, calculates the body weight increase rate of other each group chickens.
Each group incidence, the death rate, effective percentage, cure rate and body weight increase rate are counted, to the death rate, effective percentage, healing
Rate carries out Chi-square Test, and t inspections are carried out to body weight increase rate.
Blank control group chicken spirit during experiment is good, and appetite is normal, No respiratory, bowel symptoms, off-test
Dissect is without lesion afterwards.1st~5 group of chicken attack after malicious 5h start to occur it is cold, flock together, lassitude, feeding are reduced or not eaten, abdomen
The symptom such as rush down, incidence attacks up to 90% or so and occurs acute death chicken after malicious 12h successively, dead chicken dissect is found blind
Typical case's colibacillosis lesion such as intestines, duodenal hemorrhage, makes a definite diagnosis chicken ehec infection.Specific test result is shown in Table 2.
Table 2
Conclusion：Compared with positive controls, the 1st~4 group of chicken death rate is significantly lower than positive controls, and effective percentage, control
More rate is extremely notable apparently higher than positive controls, difference；1st~3 group of chicken death rate is less than drug control group, and effective percentage, control
More rate is higher than drug control group, no significant difference.
Body weight increase rate statistical result is shown in Table 3.
Table 3
Conclusion, the 1st~4 group of chicken body weight increase rate is apparently higher than positive controls, significant difference；Nothing between 1st~4 group
Significant difference.
Conclusions illustrate that Chinese medicine compound prescription antimicrobial prepared by the present invention is suitable with four yellow Zhili granule therapeutic effects.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on, should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of pharmaceutical composition of chicken colibacillosis resisting, in parts by weight, composed of the following components：
100~300 parts of the coptis,
50~150 parts of rheum officinale, and
50~150 parts of radix glycyrrhizae.
2. a kind of medicine of chicken colibacillosis resisting, it is made of pharmaceutical composition as claimed in claim 1 and pharmaceutical adjuvant, its
In, the pharmaceutical adjuvant includes 200~300 parts by weight of pharmaceutically acceptable carrier.
3. medicine according to claim 2, it is characterised in that the pharmaceutically acceptable carrier includes soluble form sediment
Powder, dextrin, glucose or sucrose.
4. the medicine according to Claims 2 or 3, it is characterised in that the pharmaceutical adjuvant further includes and is calculated as 8 by weight~
12 parts of saccharin sodium.
5. the medicine according to Claims 2 or 3, it is characterised in that the medicine is graininess.
6. a kind of preparation method of the medicine of chicken colibacillosis resisting according to any one in claim 2~5, it is wrapped
Include：
Step A, prepares the coptis-rheum officinale-licorice root ointment：Soak the coptis, rheum officinale, radix glycyrrhizae and carry out first time decoction, then mistake
Filter, the acquisition coptis, rheum officinale, radix glycyrrhizae mixing decoction liquor I, water is added into the remaining dregs of a decoction and carries out second of decoction, then filters, obtains
The coptis, rheum officinale, radix glycyrrhizae mixing decoction liquor II are obtained, merges mixing decoction liquor I and II, filters, standing, supernatant is concentrated under reduced pressure,
To obtain the final product；
Step B, prepares the medicine of chicken colibacillosis resisting：Pharmaceutical adjuvant is added into the coptis-rheum officinale-extract of licorice root, it is dry through spraying
Dry granulation, sieving, to obtain the final product.
7. preparation method according to claim 6, it is characterised in that the coptis-rheum officinale-extract of licorice root is in 20 DEG C of conditions
Under relative density be 1.32~1.35.
8. a kind of pharmaceutical composition according to claim 1 is being prepared for treating answering in the medicine of chicken colibacillosis
With.
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| CN104622989A (en) * | 2015-01-15 | 2015-05-20 | 西安医学院 | Traditional Chinese medicine compound sterilizing agent and preparation method thereof |
| CN108186752A (en) * | 2018-03-22 | 2018-06-22 | 山西福瑞沃农大生物技术工程有限公司 | A kind of herbal medicine for treating fowl bacterial diarrhea and preparation method thereof |
| CN110954645B (en) * | 2019-09-09 | 2020-09-29 | 山东琪康生物技术有限公司 | Detection method of high-quality Sihuang dysentery stopping granules |
| CN115154427B (en) * | 2022-08-15 | 2023-07-11 | 保定冀中药业有限公司 | Preparation method for improving effect of Sihuang dysentery stopping particles in treating damp-heat dysentery |
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| CN1099278A (en) * | 1993-08-22 | 1995-03-01 | 段永聚 | Compound tri-sulfonamide perlingual tablet |
| CN103110694A (en) * | 2011-11-17 | 2013-05-22 | 广东紫金正天药业有限公司 | Composition for widely treating viral diseases and application thereof |
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| KR100879032B1 (en) * | 2007-05-09 | 2009-01-15 | (주)한스킨 | Natural antibacterial extracts and cosmetic composition comprising the extracts |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099278A (en) * | 1993-08-22 | 1995-03-01 | 段永聚 | Compound tri-sulfonamide perlingual tablet |
| CN103110694A (en) * | 2011-11-17 | 2013-05-22 | 广东紫金正天药业有限公司 | Composition for widely treating viral diseases and application thereof |
Non-Patent Citations (1)
| Title |
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| 二十二种中草药对四种常见病原菌的体外抗菌活性;马俊英等;《中兽医医药杂志》;20061231(第3期);第39-41页 * |
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