CN102895378B - Pharmaceutical compound preparation for treating livestock respiratory diseases and method for preparing pharmaceutical compound preparation for treating livestock respiratory diseases - Google Patents
Pharmaceutical compound preparation for treating livestock respiratory diseases and method for preparing pharmaceutical compound preparation for treating livestock respiratory diseases Download PDFInfo
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Abstract
The invention provides a pharmaceutical compound preparation for treating livestock respiratory diseases and a method for preparing the pharmaceutical compound preparation for treating livestock respiratory diseases. The pharmaceutical compound preparation consists of exocarpium citri grandis extract, poria extract, radix glycyrrhizae extract and water-soluble florfenicol, wherein the exocarpium citri grandis extract accounts for 8-15 parts by weight, the poria extract accounts for 2-10 parts by weight, the radix glycyrrhizae extract accounts for 1-5 parts by weight, the water-soluble florfenicol accounts for 5-20 parts by weight, and the pharmaceutical compound preparation is prepared through a mixing mode. According to the pharmaceutical compound preparation for treating livestock respiratory diseases, traditional Chinese medicine and western medicine are reasonably compounded, so that the effective treatment drug for preventing livestock respiratory diseases is provided for the breeding industry; the pharmaceutical compound preparation has the functions of relieving coughs and asthma, resisting bacteria and virus, improving the immunity of the organism and the like and treats both the manifestation and root causes, the curative process is shortened, and the occurrence probability of drug resistance is greatly reduced; and the method for preparing the pharmaceutical compound preparation is simple, is convenient to use and meets the requirements of mass industrial production.
Description
Technical field
The present invention relates to a kind of drug compound preparation and preparation method thereof, especially a kind of drug compound preparation of preventing and treating livestock and birds respiratory disease and preparation method thereof.
Background technology
Livestock and birds respiratory disease increased popularity and aggravation, the development of aquaculture in serious threat, and popular area and the constantly expansion especially of outburst number of times in recent years, especially some zoonosiss are threatening the mankind's health.
Livestock and birds respiratory disease reason is various, is generally divided into three aspects: the one, non-spreading venereal diseases because of, comprise the factors such as harmful gas, stocking density in poultry house be excessive; The 2nd, spreading venereal diseases because of, comprise antibacterial, virus, parasite; The 3rd, immunosuppressive agent, comprises immunosuppressant that some viruses, physics, chemical factor cause etc.
Why important livestock and birds respiratory disease is, is due to this disease, to be present in each period in growth of animals or poultry stage on the one hand, and the fowl poultry kind of each age in days all can occur, and has a strong impact on fowl poultry kind fertility performance and product quality, and the economic loss causing is thus serious; This sick M & M is all high on the other hand, and easy other disease of secondary, it is reported, pig farm sickness rate is 30%～60%, and mortality rate reaches 5%～30%, and the mortality rate of chicken house is 10%～20%, if mixed infection Other diseases mortality rate reach more than 50%.So it is most important that the medicine of livestock and birds respiratory disease is effectively treated in exploitation.
The medicine for the treatment of respiratory tract disease be take antibiotic as main at present, but these antibiotics are mainly for pathogenic bacterium, this class medicine is often to control for the moment, easily recurrence, and the respiratory symptoms such as cough, asthma are lost control of, therefore in order to control the respiratory symptoms such as cough, always need to extend medication, this has also increased drug residue when having increased the weight of raiser's aquaculture cost, and the danger of antibacterial generation drug resistance, caused antibiotic more and more undesirable to the therapeutic effect of such disease.On the other hand, although Chinese medicine has the feature of good alleviation respiratory symptom, because it takes effect slowly, take length, be usually limited to use.Visible, a kind of medicine that can fundamentally solve respiratory tract disease is provided, can control rapidly cause of disease and can well alleviate respiratory symptom again, there is very important production practices meaning.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of drug compound preparation of preventing and treating livestock and birds respiratory disease.
Another technical problem to be solved by this invention is to provide the preparation method of the drug compound preparation of above-mentioned control livestock and birds respiratory disease.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A kind of drug compound preparation of preventing and treating livestock and birds respiratory disease, by Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract and water-solubility florfenicol, formed, by 8～15 parts of its parts by weight Exocarpium Citri Grandis extracts, 2～10 parts of Poria extracts, 1～5 part of Radix Glycyrrhizae extract, 5～20 parts of water-solubility florfenicols.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, by 9～12 parts of its parts by weight Exocarpium Citri Grandis extracts, 5～8 parts of Poria extracts, 3～4 parts of Radix Glycyrrhizae extracts, 8～13 parts of water-solubility florfenicols.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, by 10 parts of its parts by weight Exocarpium Citri Grandis extracts, 6 parts of Poria extracts, 3.5 parts of Radix Glycyrrhizae extracts, 10 parts of water-solubility florfenicols.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, by Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, water-solubility florfenicol and solubility pharmaceutic adjuvant, formed, wherein the percentage by weight of each component is Exocarpium Citri Grandis extract 8%～15%, Poria extract 2%～10%, Radix Glycyrrhizae extract 1%～5%, water-solubility florfenicol 5%～20%, solubility pharmaceutic adjuvant polishing to 100%.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, the percentage by weight of each component is Exocarpium Citri Grandis extract 9～12%, Poria extract 5～8%, Radix Glycyrrhizae extract 3～4%, water-solubility florfenicol 8～13%, solubility pharmaceutic adjuvant polishing to 100%.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, the percentage by weight of each component is Exocarpium Citri Grandis extract 10%, Poria extract 6%, Radix Glycyrrhizae extract 3.5%, water-solubility florfenicol 10%, solubility pharmaceutic adjuvant polishing to 100%.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, described Exocarpium Citri Grandis extract obtains by water boiling and extraction technique.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, the water boiling and extraction technique of described Exocarpium Citri Grandis extract comprises the steps:
(1) Exocarpium Citri Grandis raw material is blocked, shredded;
(2) add 6～8 times of water gagings of weight ratio, decoct 1h, extract for the first time, filter to obtain filtrate and filtering residue for the first time;
(3) filtering residue adds 6～8 times of water gagings more for the first time, extracts for the second time, filters to obtain filtrate and filtering residue for the second time, and filtering residue discards;
(4) mix filtrate and for the second time filtrate for the first time, being concentrated into relative density is 1.14～1.18(80 ℃), deepfreeze;
(5) obtain powdered Exocarpium Citri Grandis extract after being dried.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, described Poria extract obtains by water boiling and extraction technique.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, the water boiling and extraction technique of described Poria extract comprises the steps:
(1) Poria raw material is blocked, shredded;
(2) add 6～8 times of water gagings, decoct 1h, extract for the first time, filter to obtain filtrate and filtering residue for the first time;
(3) filtering residue adds 6～8 times of water gagings more for the first time, extracts for the second time, filters to obtain filtrate and filtering residue for the second time, and filtering residue discards;
(4) mix filtrate and for the second time filtrate for the first time, being concentrated into relative density is 1.14～1.18(80 ℃), deepfreeze;
(5) obtain powdered Poria extract after being dried.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, described Radix Glycyrrhizae extract obtains by water boiling and extraction technique.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, the water boiling and extraction technique of described Radix Glycyrrhizae extract comprises the steps:
(1) licorice raw material is blocked, shredded;
(2) add 6～8 times of water gagings, decoct 1h, extract for the first time, filter to obtain filtrate and filtering residue for the first time;
(3) filtering residue adds 6～8 times of water gagings more for the first time, extracts for the second time, filters to obtain filtrate and filtering residue for the second time, and filtering residue discards;
(4) mix filtrate and for the second time filtrate for the first time, being concentrated into relative density is 1.14～1.18(80 ℃), deepfreeze;
(5) obtain powdered Radix Glycyrrhizae extract after being dried.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, described water-solubility florfenicol is florfenicol sodium succinate, the molten florfenicol of 90% frozen water or 70% water-solubility florfenicol.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, described water-solubility florfenicol is florfenicol sodium succinate.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, described solubility pharmaceutic adjuvant is a kind of or any combination in auxiliary U.S. powder, glucose, anhydrous glucose, sucrose, shallow lake dimension powder, dextrin, starch, sodium bicarbonate.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, dosage form is peroral dosage form, usage spice drinking-water all can.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, dosage form is powder, tablet, granule or oral liquid.
Preferably, the drug compound preparation of above-mentioned control livestock and birds respiratory disease, described drug compound preparation is powder.
The preparation method of the drug compound preparation of above-mentioned control livestock and birds respiratory disease, concrete preparation process is as follows:
(1) said ratio being taken to Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract and water-solubility florfenicol is raw material;
(2) mix, stir, obtain.
Preferably, the preparation method of the drug compound preparation of above-mentioned control livestock and birds respiratory disease, concrete preparation process is as follows:
(1) said ratio being taken to Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, water-solubility florfenicol and solubility pharmaceutic adjuvant is raw material;
(2) mix, stir, obtain.
The consumption of the drug compound preparation of above-mentioned control livestock and birds respiratory disease, for by every 1kg feedstuff, adds drug compound preparation 1g of the present invention, mixed feeding, and being used in conjunction 3 is a course for the treatment of.
The invention has the beneficial effects as follows:
The drug compound preparation of above-mentioned control livestock and birds respiratory disease; by Chinese medicine and Western medicine reasonable formula; for aquaculture provides a kind of effective medicine of preventing and treating livestock and birds respiratory disease; there is cough-relieving, relieving asthma, the effect such as anti-bacteria and anti-virus, lifting immunity of organisms; treating both the principal and secondary aspects of a disease, shortening treatment have greatly reduced the occurrence probability of drug resistance in the time of the course for the treatment of; its preparation method is simple, easy to use, is applicable to the needs that large-scale industrial is produced.
The specific embodiment
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of drug compound preparation of preventing and treating livestock and birds respiratory disease, by Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, florfenicol sodium succinate and anhydrous glucose, formed, Exocarpium Citri Grandis extract 10kg wherein, Poria extract 6kg, Radix Glycyrrhizae extract 3.5kg, florfenicol sodium succinate 10kg, anhydrous glucose 70.5kg.
The preparation method of the drug compound preparation of above-mentioned control livestock and birds respiratory disease, concrete preparation process is as follows:
(1) taking above-mentioned Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, florfenicol sodium succinate and anhydrous glucose is raw material;
(2) mix, stir, obtain.
Wherein, described Exocarpium Citri Grandis extract can be obtained by following method:
(1) Exocarpium Citri Grandis raw material is blocked, shredded;
(2) add 7 times of water gagings of weight ratio, decoct 1h, extract for the first time, filter to obtain filtrate and filtering residue for the first time;
(3) filtering residue adds 7 times of water gagings more for the first time, extracts for the second time, filters to obtain filtrate and filtering residue for the second time, and filtering residue discards;
(4) mix filtrate and for the second time filtrate for the first time, being concentrated into relative density is 1.16(80 ℃), deepfreeze;
(5) obtain powdered Exocarpium Citri Grandis extract after being dried.
Described Poria extract can be obtained by following method:
(1) Poria raw material is blocked, shredded;
(2) add 7 times of water gagings, decoct 1h, extract for the first time, filter to obtain filtrate and filtering residue for the first time;
(3) filtering residue adds 7 times of water gagings more for the first time, extracts for the second time, filters to obtain filtrate and filtering residue for the second time, and filtering residue discards;
(4) mix filtrate and for the second time filtrate for the first time, being concentrated into relative density is 1.16(80 ℃), deepfreeze;
(5) obtain powdered Poria extract after being dried.
Described Radix Glycyrrhizae extract can be obtained by following method:
(1) licorice raw material is blocked, shredded;
(2) add 7 times of water gagings, decoct 1h, extract for the first time, filter to obtain filtrate and filtering residue for the first time;
(3) filtering residue adds 7 times of water gagings more for the first time, extracts for the second time, filters to obtain filtrate and filtering residue for the second time, and filtering residue discards;
(4) mix filtrate and for the second time filtrate for the first time, being concentrated into relative density is 1.16(80 ℃), deepfreeze;
(5) obtain powdered Radix Glycyrrhizae extract after being dried.
Embodiment 2
A kind of drug compound preparation of preventing and treating livestock and birds respiratory disease, by Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract and the molten florfenicol of 90% frozen water, formed Exocarpium Citri Grandis extract 8kg wherein, Poria extract 2kg, Radix Glycyrrhizae extract 1kg, the molten florfenicol 20kg of 90% frozen water.
The preparation method of the drug compound preparation of above-mentioned control livestock and birds respiratory disease, concrete preparation process is as follows:
(1) taking above-mentioned Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract and the molten florfenicol of 90% frozen water is raw material;
(2) mix, stir, obtain.
Described Exocarpium Citri Grandis extract, Poria extract and Radix Glycyrrhizae extract all obtain by water boiling and extraction technique.
Embodiment 3
A kind of drug compound preparation of preventing and treating livestock and birds respiratory disease, by Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract and 70% water-solubility florfenicol, formed Exocarpium Citri Grandis extract 15kg wherein, Poria extract 10kg, Radix Glycyrrhizae extract 5kg, 70% water-solubility florfenicol 5kg.
The preparation method of the drug compound preparation of above-mentioned control livestock and birds respiratory disease, concrete preparation process is as follows:
(1) taking above-mentioned Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract and 70% water-solubility florfenicol is raw material;
(2) mix, stir, obtain.
Described Exocarpium Citri Grandis extract, Poria extract and Radix Glycyrrhizae extract all obtain by water boiling and extraction technique.
Embodiment 4
A kind of drug compound preparation of preventing and treating livestock and birds respiratory disease, by Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, florfenicol sodium succinate and auxiliary U.S. powder, formed, Exocarpium Citri Grandis extract 9kg wherein, Poria extract 8kg, Radix Glycyrrhizae extract 3kg, florfenicol sodium succinate 13kg, auxiliary U.S. powder 67kg.
The preparation method of the drug compound preparation of above-mentioned control livestock and birds respiratory disease, concrete preparation process is as follows:
(1) taking above-mentioned Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, florfenicol sodium succinate and auxiliary U.S. powder is raw material;
(2) mix, stir, obtain.
Described Exocarpium Citri Grandis extract, Poria extract and Radix Glycyrrhizae extract all obtain by water boiling and extraction technique.
Embodiment 5
A kind of drug compound preparation of preventing and treating livestock and birds respiratory disease, by Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, florfenicol sodium succinate and starch, formed, Exocarpium Citri Grandis extract 12kg wherein, Poria extract 5kg, Radix Glycyrrhizae extract 4kg, florfenicol sodium succinate 8kg, starch 71kg.
The preparation method of the drug compound preparation of above-mentioned control livestock and birds respiratory disease, concrete preparation process is as follows:
(1) taking above-mentioned Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, florfenicol sodium succinate and starch is raw material;
(2) mix, stir, obtain.
Described Exocarpium Citri Grandis extract, Poria extract and Radix Glycyrrhizae extract all obtain by water boiling and extraction technique.
Embodiment 6
A kind of drug compound preparation of preventing and treating livestock and birds respiratory disease, by Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract and florfenicol sodium succinate, formed Exocarpium Citri Grandis extract 10kg wherein, Poria extract 7kg, Radix Glycyrrhizae extract 4kg, florfenicol sodium succinate 11kg.
The preparation method of the drug compound preparation of above-mentioned control livestock and birds respiratory disease, concrete preparation process is as follows:
(1) taking above-mentioned Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, florfenicol sodium succinate and solubility pharmaceutic adjuvant is raw material;
(2) mix, stir, obtain.
Described Exocarpium Citri Grandis extract, Poria extract and Radix Glycyrrhizae extract all obtain by water boiling and extraction technique.
Embodiment 7
A kind of drug compound preparation of preventing and treating livestock and birds respiratory disease, by Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, the molten florfenicol of 90% frozen water, shallow lake dimension powder and sodium bicarbonate, formed, Exocarpium Citri Grandis extract 11kg wherein, Poria extract 6kg, Radix Glycyrrhizae extract 4kg, the molten florfenicol 9kg of 90% frozen water, the dimension of forming sediment powder 60kg, sodium bicarbonate 10kg.
The preparation method of the drug compound preparation of above-mentioned control livestock and birds respiratory disease, concrete preparation process is as follows:
(1) taking above-mentioned Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, the molten florfenicol of 90% frozen water, shallow lake dimension powder and sodium bicarbonate is raw material;
(2) mix, stir, obtain.
Described Exocarpium Citri Grandis extract, Poria extract and Radix Glycyrrhizae extract all obtain by water boiling and extraction technique.
The described Chinese crude drug of one of embodiment 1-7 is commercially available prod, and each amounts of components is increased or reduced according to same ratio, and the parts by weight relation of each component of gained all belongs to protection scope of the present invention.
Described in embodiment 1-7, Chinese crude drug all meets < < Chinese veterinary pharmacopoeia > > version two ministerial standards in 2010.
The composition principle of drug compound preparation of the present invention is: in side Exocarpium Citri Grandis extract there is expelling phlegm for arresting cough, the effect such as the relieving dyspepsia of regulating the flow of vital energy, antiinflammatory, antioxidation; Poria extract has promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming, immunostimulant, the effects such as sterilizing and anti-virus antitumor; Radix Glycyrrhizae extract have the effect of preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, also can coordinating the actions of various ingredients in a prescription; Water-solubility florfenicol, is broad spectrum antibiotic, and the respiratory system disease that livestock and poultry caused by sensitive bacteria is caused and intestinal infection disease have specially good effect.All medicines share, and mutually Synergistic, remarkably productive to control livestock and birds respiratory disease, be embodied in following some:
(1) in drug compound preparation of the present invention, but Western medicine kills the cause of disease that causes respiratory tract disease rapidly, plays the effect effecting a permanent cure, Chinese medicine by cough-relieving, relieving asthma, the effect such as lung moistening and assisting sterilisation antiviral, play the effect taking stopgap measures, the two combination, complement each other, treating both the principal and secondary aspects of a disease, improves curative effect;
(2) in side, Poria extract has the effect that promotes immunity of organisms, solves immunity of organisms low, is subject to the problem that pathogen is attacked;
(3) by the synergism of Chinese medicine and Western medicine, antibacterial effect is remarkable, and rapidly, Shorten the Treatment Process, has reduced the generation of drug resistance in effect;
(4) spice, drinking-water all can be used, easy to use, because Chinese medicine ingredients adopts extract, have solved Chinese medicine content of cellulose high, the heavy problem of poultry simultaneously.
Clinical trial example:
(1) experimental animal
300 20 age in days broiler chicken, Tianjin chicken house provides, and ataxia, dyspnea appear in this batch of chicken, stretch neck dehisces to breathe; Pathological changes is mainly: in nasal cavity, trachea, bronchus, have faint yellow translucent viscosity exudate.Be infectious bronchitis of chicken after diagnosing.
(2) trial drug
The powder that the embodiment of the present invention 1 is prepared.
(3) EXPERIMENTAL DESIGN and method
300 chickens of morbidity are divided into 3 groups, 100 every group at random.
Test group 1 is blank group, not medication;
Test group 2 is treatment matched group, commercially available moroxydine+commercially available water-solubility florfenicol (florfenicol sodium succinate, Hui Meng bio tech ltd, Jinan), mixed feeding, wherein usage ratio is closed and is: every moroxydine 1g+ winestone water-solubility florfenicol 0.5g spice 1kg, is used in conjunction 3;
Test group 3 is treatment group, mixed feeding, and drug compound preparation described in the embodiment of the present invention 1, wherein usage ratio is closed and is: every 1g drug compound preparation spice 1kg, is used in conjunction 3.
In duration of test, chicken is conventional to be raised, and free choice feeding and drinking-water, observe and record treatment situation.Test grouping and disposition are in Table 1.
Table 1 test grouping and disposition
(4) the standard of curative effect evaluation
Inefficiency: at duration of test, occur dead or and do not feel any better or become even more serious sick chicken number and account for this and organize total ratio.
Effective percentage: after off-test, spirit, respiratory symptom, appetite etc. obviously occur that the sick chicken number taking a turn for the better accounts for this and organizes total ratio.
Cure rate: after off-test, spirit, respiratory symptom, appetite etc. are recovered normal sick chicken number completely and accounted for this and organize total ratio.
(4) result of the test.Result of the test is in Table 2.
Table 2 result of the test
| Group | Test number | Death toll (only) | Cure rate (%) | Effective percentage (%) | Inefficiency (%) |
| Test group 1 | 100 | 75 | 6 | 7 | 87 |
| Test group 2 | 100 | 6 | 83 | 6 | 11 |
| Test group 3 | 100 | 2 | 95 | 2 | 3 |
As seen from the results in Table 2, take the test group 3 chicken group cure rates of drug compound preparation described in the embodiment of the present invention 1 and be significantly higher than test group 1, compared with test group 2, also embodied obvious healing advantage simultaneously.
Above-mentioned detailed description of this kind of drug compound preparation of preventing and treating livestock and birds respiratory disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (10)
1. a drug compound preparation of preventing and treating livestock and birds respiratory disease, it is characterized in that: by Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract and water-solubility florfenicol, formed, by 8～15 parts of its parts by weight Exocarpium Citri Grandis extracts, 2～10 parts of Poria extracts, 1～5 part of Radix Glycyrrhizae extract, 5～20 parts of water-solubility florfenicols, described Exocarpium Citri Grandis extract obtains by water boiling and extraction technique, described Poria extract obtains by water boiling and extraction technique, and described Radix Glycyrrhizae extract obtains by water boiling and extraction technique.
2. the drug compound preparation of control livestock and birds respiratory disease according to claim 1, is characterized in that: by 9～12 parts of its parts by weight Exocarpium Citri Grandis extracts, and 5～8 parts of Poria extracts, 3～4 parts of Radix Glycyrrhizae extracts, 8～13 parts of water-solubility florfenicols.
3. the drug compound preparation of control livestock and birds respiratory disease according to claim 2, is characterized in that: by 10 parts of its parts by weight Exocarpium Citri Grandis extracts, and 6 parts of Poria extracts, 3.5 parts of Radix Glycyrrhizae extracts, 10 parts of water-solubility florfenicols.
4. the drug compound preparation of control livestock and birds respiratory disease according to claim 1, is characterized in that: described water-solubility florfenicol is florfenicol sodium succinate, the molten florfenicol of 90% frozen water or 70% water-solubility florfenicol.
5. a drug compound preparation of preventing and treating livestock and birds respiratory disease, it is characterized in that: by Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, water-solubility florfenicol and solubility pharmaceutic adjuvant form, wherein the percentage by weight of each component is Exocarpium Citri Grandis extract 8%～15%, Poria extract 2%～10%, Radix Glycyrrhizae extract 1%～5%, water-solubility florfenicol 5%～20%, solubility pharmaceutic adjuvant polishing to 100%, described Exocarpium Citri Grandis extract obtains by water boiling and extraction technique, described Poria extract obtains by water boiling and extraction technique, described Radix Glycyrrhizae extract obtains by water boiling and extraction technique.
6. the drug compound preparation of control livestock and birds respiratory disease according to claim 5, it is characterized in that: the percentage by weight of each component is Exocarpium Citri Grandis extract 9～12%, Poria extract 5～8%, Radix Glycyrrhizae extract 3～4%, water-solubility florfenicol 8～13%, solubility pharmaceutic adjuvant polishing to 100%.
7. the drug compound preparation of control livestock and birds respiratory disease according to claim 6, it is characterized in that: the percentage by weight of each component is Exocarpium Citri Grandis extract 10% Poria extract 6%, Radix Glycyrrhizae extract 3.5%, water-solubility florfenicol 10%, solubility pharmaceutic adjuvant polishing to 100%.
8. the drug compound preparation of control livestock and birds respiratory disease according to claim 5, is characterized in that: described drug compound preparation is powder.
9. the preparation method of the drug compound preparation of the described control livestock and birds respiratory disease of one of claim 1-3, concrete preparation process is as follows:
(1) said ratio being taken to Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract and water-solubility florfenicol is raw material;
(2) mix, stir, obtain.
10. the preparation method of the drug compound preparation of the described control livestock and birds respiratory disease of one of claim 5-7, is characterized in that: concrete preparation process is as follows:
(1) said ratio being taken to Exocarpium Citri Grandis extract, Poria extract, Radix Glycyrrhizae extract, water-solubility florfenicol and solubility pharmaceutic adjuvant is raw material;
(2) mix, stir, obtain.
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| CN103520211B (en) * | 2013-10-23 | 2015-10-07 | 天津市中升挑战生物科技有限公司 | A kind of compound florfenicol injection and preparation method thereof and application |
| CN105030882A (en) * | 2015-07-06 | 2015-11-11 | 四川省畜牧科学研究院 | Medicine compound preparation for preventing and treating respiratory diseases of livestock and poultry, and preparation method thereof |
| CN105168444B (en) * | 2015-10-10 | 2019-02-19 | 湖北武当动物药业有限责任公司 | One kind is for preventing and treating livestock and poultry respiratory syndrome drug |
| CN105748656A (en) * | 2016-03-02 | 2016-07-13 | 江西傲新生物科技有限公司 | Medicine preparation for preventing and treating bacterial respiratory diseases of livestock and poultry and preparation method thereof |
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| CN102755431A (en) * | 2012-07-26 | 2012-10-31 | 山东百德生物科技有限公司 | Chinese medicinal preparation for treating porcine respiratory disease syndrome and preparation method thereof |
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