CN102940722B - A kind ofly treat Chinese medicine composition of fowl bacterial disease and preparation method thereof - Google Patents
A kind ofly treat Chinese medicine composition of fowl bacterial disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses and a kind ofly treat Chinese medicine composition of fowl bacterial disease and preparation method thereof.This Chinese medicine composition contains active component, and described active component is made up of Herba Houttuyniae, Herba Portulacae, Herba Plantaginis, Radix Platycodonis, Herba Taraxaci, Fructus Trichosanthis, Fructus Rosae Laevigatae and Mahonia fortunei (Lindl.) Fedde.Chinese medicine of the present invention can be effective to the diseases such as yellow and white dysentery of piglet, Pullorum Disease, avian Escherichia coli disease, chicken staphylococcosis, infectious laryngotracheitis of chicken, Riemerellosis Anatipestifer disease, there is safety, environmental protection, have no side effect, the features such as preparation technology is simple, production cost is low.
Description
Technical field
The present invention relates to and a kind ofly treat Chinese medicine composition of fowl bacterial disease and preparation method thereof, belong to field of veterinary.
Background technology
Current, China is intensive, the development that deepens continuously of large-scale cultivation industry, in recent years the puzzlement of the extremely various infectiousness epidemic disease of aquaculture.Livestock and poultry takes place frequently, and causes massive losses to China's aquaculture, and becomes the key factor of impact restriction China animal husbandry development.China is one of egg production state the biggest in the world, but the various diseases of poultry cause huge loss to China's aviculture, and the bacterial disease as chicken comprises that Pullorum Disease, chicken colibacillosis, chicken staphylococcosis are sick, infectious coryza of chicken etc.Animal derived pathogen passes to people by food chain, causes food-safety problem, the serious threat health of the mankind.In addition, also can affect export abroad trade, cause aquaculture cost constantly to rise, peasant burden increases the weight of.
At present, the medicine great majority of control fowl bacterial disease are antibiotic and chemosynthesis antibacterials, as enrofloxacin, streptomycin, gentamycin, amoxicillin, sulfonamides etc.Although veterinary clinic according to circumstances carries out alternately or conbined usage medicine, because the extensive use of antibacterials is even abused, Resistant strain gets more and more.As Drug Resistance of E. coli develops rapidly, propagates extensive, intensity increase, fastbacteria develops into multidrug resistant by single drug resistance.20 century 70s four are resistance to, five resistance to bacterial strains are in the majority, and the eighties five is resistance to, six resistance to, seven resistance to bacterial strains account for the overwhelming majority, and the nineties seven, resistance to above bacterial strain ratio was close to 90%.Because bacterial resistance sexual development is rapid, drug resistance intensity increases, and causes medication effect to decline, and make disease be difficult to control, bacterial disease has become the main infectious disease in chicken farm now.For fowl bacterial disease, still mainly use antibiotic or chemosynthesis antibacterials to treat at present, but antibacterial easily produces drug resistance to chemicals, and chemicals toxic and side effects is larger, often only cure the symptoms, not the disease, unfavorable factor is brought to the entirety control of disease.Meanwhile, the use of chemicals also affects the safety of animal food, and harm humans is healthy.
Chinese herbal medicine belongs to pure natural substance, containing multiple biological effective components, has antibacterial, antiinflammatory, not easily produces the features such as bacterial drug resistance, low toxicity, noresidue or low-residual, have medicine and nutrition dual-use function concurrently, not only take stopgap measures but also effect a permanent cure.Therefore, Chinese herbal medicine is substituted chemicals, to prevent and treat fowl bacterial disease, there is larger economic benefit and environment protection significance.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, the Chinese medicine composition for the treatment of fowl bacterial disease of a kind of safety, environmental protection, good effect, no drug residue and drug resistance is provided.
Another object of the present invention is to provide the preparation method of this treatment fowl bacterial disease Chinese medicine composition.
The invention provides a kind of Chinese medicine composition for the treatment of fowl bacterial disease, containing active component, described active component is made up of Herba Houttuyniae, Herba Portulacae, Herba Plantaginis, Radix Platycodonis, Herba Taraxaci, Fructus Trichosanthis, Fructus Rosae Laevigatae and Mahonia fortunei (Lindl.) Fedde.。
Wherein, Herba Houttuyniae 10-30 part, Herba Portulacae 10-30 part, Herba Plantaginis 5-25 part, Radix Platycodonis 5-25 part, Herba Taraxaci 5-25 part, Fructus Trichosanthis 5-25 part, Fructus Rosae Laevigatae 3-20 part, Mahonia fortunei (Lindl.) Fedde 3-20 part.
Further, Herba Houttuyniae 15-25 part, Herba Portulacae 15-25 part, Herba Plantaginis 10-20 part, Radix Platycodonis 10-20 part, Herba Taraxaci 10-20 part, Fructus Trichosanthis 10-20 part, Fructus Rosae Laevigatae 5-15 part, Mahonia fortunei (Lindl.) Fedde 5-15 part.
Further, Herba Houttuyniae 20 parts, Herba Portulacae 20 parts, Herba Plantaginis 15 parts, Radix Platycodonis 15 parts, Herba Taraxaci 15 parts, Fructus Trichosanthis 15 parts, Fructus Rosae Laevigatae 10 parts, Mahonia fortunei (Lindl.) Fedde 10 parts.
Wherein, the dosage form of described Chinese medicine composition can be: pre-mixing agent, powder, powder, tablet, granule, oral liquid or injection.
Present invention also offers the preparation method of this treatment fowl bacterial disease Chinese medicine composition, comprise the steps:
(1) each medicine material is taken by weight ratio;
(2) each medicine material claimed is pulverized, sieve after maybe by each medicine material of claiming through water or alcohol extraction, concentrated after, then add pharmacy can adjuvant or complementary composition, be prepared from.
Wherein, the Chinese powder medicine of the treatment fowl bacterial disease obtained by described preparation method, its diameter of aspirin particle is below 50 microns.
The present invention also provides the Chinese medicine composition of described treatment fowl bacterial disease for the preparation of in treatment fowl bacterial disease medicament or for the preparation of the application in anti-fowl bacterial disease feedstuff.
Each drug component in Chinese medicine of the present invention and consumption thereof be according to Chinese veterinarian's prescription dialectical treatmert principle, gets by repeatedly practising in a large number.Chinese medicine of the present invention has heat-clearing and toxic substances removing, the function of eliminating pathogenic heat from blood to cure dysentery, after being prepared into pharmaceutically conventional preparation, cures mainly fowl bacterial disease.Chinese medicine of the present invention also can add in feedstuff, is prepared into the feedstuff of anti-fowl bacterial disease.
Advantage and the beneficial effect of medicine of the present invention are:
1) medicine of the present invention plays Chinese medicine organic conception and dialectically treats theory, good effect, instant effect, treating both the principal and secondary aspects of a disease, can be used for the diseases such as control yellow and white dysentery of piglet, Pullorum Disease, avian Escherichia coli disease, chicken staphylococcosis, infectious laryngotracheitis of chicken, Riemerellosis Anatipestifer disease;
2) Chinese medicine of the present invention adopts modern pharmaceutical technology to be prepared, and uses modern means of science and technology to carry out qualitative and quantitative detection to Effective Component of Chinese Medicine, constant product quality, controlled, has the stronger market competitiveness;
3) medicine of the present invention is pure Chinese medicinal preparation, and toxic and side effects is little, the drug residue that can not produce harm humans health, not easily produce drug resistance, free from environmental pollution;
4) medicine of the present invention can be absorbed fast and be played due drug effect in animal body, the modes such as mixed drink, mixed feeding can be adopted simultaneously to concentrate administration, be beneficial to mass prevention and mass treatment;
5) medicine material wide material sources of the present invention, production technology is simple, easy to use, with low cost, has saved medication expense widely.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1 medicine preparation of the present invention and use
1) raw material containing following weight is taken:
Herba Houttuyniae 30 parts, Herba Portulacae 30 parts, Herba Plantaginis 25 parts, Radix Platycodonis 25 parts, Herba Taraxaci 25 parts, Fructus Trichosanthis 25 parts, Fructus Rosae Laevigatae 20 parts, Mahonia fortunei (Lindl.) Fedde 20 parts
2), after being pulverized by each weight crude drug claimed in step 1), sieving, fully powder is mixed with into.
3) drug use method of the present invention: bacterial disease, mixed feeding: poultry, fowl, every 1kg feedstuff adds Chinese medicine 5-10g of the present invention, is used in conjunction 5-7 day.
Embodiment 2 medicine preparation of the present invention and use
1) raw material containing following weight is taken:
Herba Houttuyniae 10 parts, Herba Portulacae 10 parts, Herba Plantaginis 5 parts, Radix Platycodonis 5 parts, Herba Taraxaci 5 parts, Fructus Trichosanthis 5 parts, Fructus Rosae Laevigatae 3 parts, Mahonia fortunei (Lindl.) Fedde 3 parts
2) after each weight proportion crude drug claimed in step 1) being pulverized, after first medical material being soaked 2 hours with ethanol, alcohol reflux 2 times, each 2 hours, merging filtrate was also condensed into paste; Filtering residue uses water extraction 2 times again, and first time extracts 2.5 hours, and second time is extracted 1.5 hours, and filter, merging filtrate is also condensed into paste; Merge extractum, finally add appropriate amount of starch and dextrin (or other adjuvant), mix homogeneously, makes soft material, granulates, and dries, is namely prepared into granule (every 1g is equivalent to crude drug in whole 1g).
3) drug use method of the present invention: bacterial disease, mixed drink: poultry, fowl, every 1L water adds medicine 2-5g of the present invention, freely drinks, and is used in conjunction 5-7 day.
Embodiment 3 medicine preparation of the present invention and use
1) raw material containing following weight is taken:
Herba Houttuyniae 25 parts, Herba Portulacae 25 parts, Herba Plantaginis 20 parts, Radix Platycodonis 20 parts, Herba Taraxaci 20 parts, Fructus Trichosanthis 20 parts, Fructus Rosae Laevigatae 15 parts, Mahonia fortunei (Lindl.) Fedde 15 parts
2) after each weight proportion crude drug claimed in step 1) being pulverized, after first medical material being soaked 2 hours with ethanol, alcohol reflux 2 times, each 2 hours, merging filtrate was also condensed into paste; Filtering residue uses water extraction 2 times again, and first time extracts 2.5 hours, and second time is extracted 1.5 hours, and filter, merging filtrate is also condensed into paste; Merge extractum, finally add appropriate amount of starch and dextrin (or other adjuvant), mix homogeneously, dry, pulverize, be namely prepared into powder (every 1g is equivalent to crude drug in whole 1g).
3) drug use method of the present invention: bacterial disease, mixed feeding: poultry, fowl, every 1kg feedstuff adds medicine 5-10g of the present invention, is used in conjunction 5-7 day.
Embodiment 4 medicine preparation of the present invention and use
1) raw material containing following weight is taken:
Herba Houttuyniae 15 parts, Herba Portulacae 15 parts, Herba Plantaginis 10 parts, Radix Platycodonis 10 parts, Herba Taraxaci 10 parts, Fructus Trichosanthis 10 parts, Fructus Rosae Laevigatae 5 parts, Mahonia fortunei (Lindl.) Fedde 5 parts
2) after being pulverized by each weight proportion crude drug claimed in step 1), after medical material being soaked 1-2 hour with water, then decoct to boiling with high heat, then use slow fire boiling 30 minutes, filter, filtering residue adds water with slow fire boiling twice, each 1 hour.Merging filtrate, is concentrated into 160 milliliters by filtrate, adding ethanol content in ethanol to filtrate is 70%, and filter, filtrate recycling ethanol, be concentrated into every 1ml and be equivalent to crude drug in whole 0.5g, filtration, embedding, sterilizing, be namely prepared into oral liquid.
3) drug use method of the present invention: bacterial disease, mixed drink: poultry, fowl, every 1L water adds medicine 5-10ml of the present invention, freely drinks, and is used in conjunction 7.
Embodiment 5 medicine preparation of the present invention and use
(1) raw material containing following weight is taken:
Herba Houttuyniae 20 parts, Herba Portulacae 20 parts, Herba Plantaginis 15 parts, Radix Platycodonis 15 parts, Herba Taraxaci 15 parts, Fructus Trichosanthis 15 parts, Fructus Rosae Laevigatae 10 parts, Mahonia fortunei (Lindl.) Fedde 10 parts.
(2), after each weight proportion crude drug claimed in step (1) being pulverized, after medical material being soaked 1-2 hour with water, then decoct to boiling with high heat, then use slow fire boiling 30 minutes, filter, filtering residue slow fire boiling twice, each 1 hour.Merging filtrate, is concentrated into 120 milliliters by filtrate, adding ethanol content in ethanol to filtrate is 70%, and filter, filtrate recycling ethanol, be concentrated into every 1ml and be equivalent to crude drug in whole 1g, cold preservation, filtration, fine straining, embedding, sterilizing, be namely prepared into injection.
(3) drug use method of the present invention: bacterial disease, intramuscular injection, each every 1kg body weight, sheep, pig 0.1-0.2ml/kg, rabbit, fowl 0.2ml, 2 times on the one, be used in conjunction 5-7 day.Embodiment 6 medicine preparation of the present invention and use
1) raw material containing following weight is taken:
Herba Houttuyniae 30 parts, Herba Portulacae 30 parts, Herba Plantaginis 20 parts, Radix Platycodonis 20 parts, Herba Taraxaci 20 parts, Fructus Trichosanthis 15 parts, Fructus Rosae Laevigatae 15 parts, Mahonia fortunei (Lindl.) Fedde 10 parts.
2) after each weight proportion crude drug claimed in step 1) being pulverized, after first medical material being soaked 2 hours with ethanol, alcohol reflux 2 times, each 2 hours, merging filtrate was also condensed into extractum; Filtering residue uses water extraction 2 times again, and first time extracts 2.5 hours, and second time is extracted 1.5 hours, filter, merging filtrate is also condensed into extractum, finally adds appropriate amount of starch, magnesium stearate, granulation, tabletting, the every 1g of every sheet 0.2g(is equivalent to crude drug in whole 2g), be namely prepared into tablet.
3) drug use method of the present invention: bacterial disease, rabbit, fowl 1-2 sheet, be used in conjunction 5-7 day.
For showing the prevention effect of medicine of the present invention to fowl bacterial disease, clinical observation on the therapeutic effect test being carried out to medicine of the present invention, sets forth the beneficial effect of medicine of the present invention below by way of test example further.
Test example 1
In May, 2012, Macheng City of Hubei Province newly buys on pig farm piglet 120, and body weight is about 15kg, raises after 5 days, and white, the faint yellow or canescence thickness of part piglet milk ejection has the symptoms such as special stench pasty state feces, and affected pig spirit still can.According to epidemiology, clinical symptoms diagnosis, be diagnosed as piglet pujos blancos.Adopt embodiment 5 to prepare medicine of the present invention, drug administration by injection, every 3.0ml, continuous use 5 days, drug withdrawal was paid a return visit after 4 days, and raiser reflects that affected pig has stopped diarrhoea, and appetite, mental restoration are normal.
Test example 2
In November, 2011, Rongchang County, Chongqing chicken house newly introduces 600 plumage 14 Japanese instar chicklings, and diarrhoea appears in part chicken, arranges thin white paste sample feces, perianal tomentum fecal pollution, seals anus, affect defecation after dry.Blind or the arthritis of some generations, limping, the many symptoms of waiting indefinitely because of dyspnea and heart failure of sick chickling.According to epidemiology, clinical symptoms, cut open inspection change and laboratory diagnosis, be diagnosed as white diarrhea disease.200 of wherein serious symptom chickling are selected to be divided into 8 groups for examination.
Test grouping and administration: test is divided into 8 groups, test 1 group and adopt embodiment 1 to prepare, mixed feeding administration, per kilogram feedstuff adds Chinese medicine 10g of the present invention; Testing 2 groups adopts embodiment 2 to prepare, the administration of mixed drink, and every 1L water adds Chinese medicine 5g of the present invention, freely drinks; Testing 3 groups adopts embodiment 3 to prepare, mixed feeding administration, and per kilogram feedstuff adds Chinese medicine 10g of the present invention; Testing 4 groups adopts embodiment 4 to prepare, the administration of mixed drink, and every 1L water adds Chinese medicine 10ml of the present invention; Testing 5 groups adopts embodiment 5 to prepare, intramuscular injection, every plumage 0.05ml; Testing 6 groups adopts embodiment 6 to prepare, 1, every plumage; Test 7 groups and adopt herbal medicine Radix Pulsatillae powders, mixed feeding administration, per kilogram feedstuff adds the Radix Pulsatillae and to fall apart 10g; The not administration of blank group; Each test group is used in conjunction 7.Continue observation after off-test 2, statistical results, in table 2.
Table 2 medicine of the present invention is added up Pullorum Disease curative effect
Result of the test shows: medicine of the present invention and the Radix Pulsatillae fall apart and have good prevention effect to Pullorum Disease; Between each test group of medicine of the present invention, be best to test 5 groups of curative effects, test 3 groups and take second place with test 4 groups; Curative effect of medication of the present invention significantly will be better than the Radix Pulsatillae and fall apart.
Test example 3
In July, 2012, there is chest and the subcutaneous generation edema of thigh in the chicken of the chicken house of Inner Mongol raiser, outward appearance is aubergine or atropurpureus, there is fluctuation, local sheds feathers, and wing, chest, the subcutaneous of back have serous exudate, skin edema, fester, the symptom such as stench.According to epidemiology, clinical symptoms, cut open inspection change and laboratory diagnosis, be diagnosed as chicken staphylococcosis.The sick chicken selecting the wherein state of an illness more serious 240, is divided into 4 test group: test 1 group and adopt embodiment 2 to prepare, the administration of mixed drink, every 1L water adds Chinese medicine 5g of the present invention; Testing 2 groups adopts embodiment 3 to prepare, mixed feeding administration, and per kilogram feedstuff adds Chinese medicine 10g of the present invention; Test 3 groups and adopt the loose mixed feeding administrations of the white dragon of herbal medicines, per kilogram feedstuff Jia Bailong falls apart 10g; Blank group does not add any medicine; Each test group is used in conjunction 7.Continue observation after off-test 4, statistical results, in table 3.
Table 3 Chinese medicine of the present invention is added up the curative effect of chicken staphylococcosis
Result of the test shows: compared with blank group, and drug test group of the present invention and white dragon fall apart and have good prevention effect to chicken staphylococcosis, and curative effect of medication of the present invention is significantly better than Bai Long and falls apart.
Test example 4
In November, 2011, the duck in Liu Panshui duck field, Guizhou 6-8 age in week is sudden death without any manifest symptom, and main clinic symptoms is somnolence, necking down, and beak supports ground, and bipod is weak, is reluctant to walk about, is slow in action, ataxia, loss of appetite or anorexia.Eye have serosity or mucus secretions, often make two near the eyes feather adhesion come off, also flow out serosity or mucus secretions in nostril.Feces is thin, and in green or yellow green, part duckling abdominal distension, the symptom of nervous disorder appears in agonal stage, and as shaken the head, nod or carrying on the back neck, two limbs stretch in opisthotonus state, and tarsal joint swelling appears in some cases, walk lamely, can not lie prostrate.Riemerellosis Anatipestifer disease is diagnosed as according to epidemiology, clinical symptoms.The duck isolated rearing be in a bad way, adopt embodiment 6 to prepare medicine of the present invention to 109 ducks of isolated rearing and treat, 1, every plumage; Only adopt embodiment 1 to prepare medicine of the present invention to all the other ducks, mixed feeding administration, per kilogram feedstuff adds Chinese medicine 10g of the present invention.Through using medicine of the present invention to pay a return visit after 7 days continuously, except 11 serious sick duck death, all the other 98 sick ducks are almost recovered, and disease does not appear in all the other groups.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
1. treat the Chinese medicine composition of fowl bacterial disease for one kind, containing active component, described active component is made up of Herba Houttuyniae, Herba Portulacae, Herba Plantaginis, Radix Platycodonis, Herba Taraxaci, Fructus Trichosanthis, Fructus Rosae Laevigatae and Mahonia fortunei (Lindl.) Fedde, it is characterized in that, Herba Houttuyniae 10-30 part, Herba Portulacae 10-30 part, Herba Plantaginis 5-25 part, Radix Platycodonis 5-25 part, Herba Taraxaci 5-25 part, Fructus Trichosanthis 5-25 part, Fructus Rosae Laevigatae 3-20 part, Mahonia fortunei (Lindl.) Fedde 3-20 part.
2. the Chinese medicine composition for the treatment of fowl bacterial disease according to claim 1, it is characterized in that, Herba Houttuyniae 15-25 part, Herba Portulacae 15-25 part, Herba Plantaginis 10-20 part, Radix Platycodonis 10-20 part, Herba Taraxaci 10-20 part, Fructus Trichosanthis 10-20 part, Fructus Rosae Laevigatae 5-15 part, Mahonia fortunei (Lindl.) Fedde 5-15 part.
3. the Chinese medicine composition for the treatment of fowl bacterial disease according to claim 2, is characterized in that, Herba Houttuyniae 20 parts, Herba Portulacae 20 parts, Herba Plantaginis 15 parts, Radix Platycodonis 15 parts, Herba Taraxaci 15 parts, Fructus Trichosanthis 15 parts, Fructus Rosae Laevigatae 10 parts, Mahonia fortunei (Lindl.) Fedde 10 parts.
4. the Chinese medicine composition of the treatment fowl bacterial disease according to any one of claim 1-3, it is pre-mixing agent.
5. the Chinese medicine composition of the treatment fowl bacterial disease described in any one of claim 1-3, it is powder, powder, tablet, granule, oral liquid or injection.
6. the preparation method of the Chinese medicine composition of the treatment fowl bacterial disease described in any one of claim 1-5, comprises the steps:
1) each medicine material is taken by weight ratio;
2) each medicine material claimed is pulverized, sieve after maybe by each medicine material of claiming through water or alcohol extraction, concentrated after, then add pharmacy can adjuvant, be prepared from.
7. the Chinese medicine composition composition powders made of preparation method according to claim 6, it is characterized in that, its diameter of aspirin particle is below 50 microns.
8. the Chinese medicine composition of the treatment fowl bacterial disease described in any one of claim 1-5 is for the preparation of the application in treatment fowl bacterial disease medicament.
9. the Chinese medicine composition of the treatment fowl bacterial disease described in any one of claim 1-5 is for the preparation of the application in anti-fowl bacterial disease feedstuff.
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| CN104012464B (en) * | 2014-05-15 | 2016-08-31 | 安顺市湘香养殖有限责任公司 | A kind of prevention and the cultural method for the treatment of duck disease |
| CN104222637B (en) * | 2014-09-12 | 2016-08-24 | 无锡肽旗生物科技有限公司 | A kind of ablactational baby pig mixed feed |
| CN105053646A (en) * | 2015-08-07 | 2015-11-18 | 杨珊洪 | Mandarin fish disease resistance improving feed additive |
| CN105168516A (en) * | 2015-10-13 | 2015-12-23 | 钟云仙 | Compound Chinese herbal medicinal powder for treating chronic respiratory disease of livestock and poultry and preparation method of compound Chinese herbal medicinal powder |
| CN109170224A (en) * | 2018-11-28 | 2019-01-11 | 江西中成人药业有限公司 | A kind of natural compounding type Chinese medicine fodder of substitute antibiotics |
| CN113940966B (en) * | 2021-11-09 | 2023-07-07 | 江西普正制药股份有限公司 | Callicarpa nudiflora composition for treating escherichia coli infection and preparation method and application thereof |
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Effective date of registration: 20220706 Address after: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee after: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee after: Shaoshan Da Bei Nong Animal Pharmaceutical Co., Ltd. Address before: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee before: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee before: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd. Patentee before: Shaoshan Dabeinong Animal Medicine Co.,Ltd. |