CN102940722A - Chinese medicinal composition for treating bacterial diseases of animals and preparation method thereof - Google Patents
Chinese medicinal composition for treating bacterial diseases of animals and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating bacterial diseases of animals and a preparation method thereof. The Chinese medicinal composition contains an active ingredient which is prepared from houttuynia, purslane, plantain herb, platycodon grandiflorum, dandelion, snakegourd fruit, cherokee rose fruit and mahonia fortunei. The composition can be effectively used for treating the diseases such as piglet's yellow-white dysentery, pullorum disease, chicken colibacillosis, avian staphylocosis, chicken's infectious laryngotracheitis and riemerella anatipestifersis, has the characteristics of safety, environment friendliness, simple preparation process, low production cost and the like, and does not have toxic or side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of the fowl bacterial disease and preparation method thereof, belong to field of veterinary.
Background technology
Current, China is intensive, the development that deepens continuously of large-scale cultivation industry, the in recent years puzzlement of the extremely various infectiousness epidemic diseases of aquaculture.Livestock and poultry takes place frequently, and has caused massive losses for China's aquaculture, and becomes the key factor of impact restriction China animal husbandry development.China is one of egg production state the biggest in the world, but the various diseases of poultry has caused huge loss to China's aviculture, as the bacterial disease of chicken comprise that Pullorum Disease, chicken colibacillosis, chicken staphylococcosis are sick, infectious coryza of chicken etc.Animal derived pathogen passes to the people by food chain, has caused food-safety problem, serious threat human health.In addition, also can affect the export abroad trade, cause the aquaculture cost constantly soaring, peasant burden increases the weight of.
At present, the medicine great majority of control fowl bacterial disease are antibiotic and chemosynthesis antibacterials, such as enrofloxacin, streptomycin, gentamycin, amoxicillin, sulfonamides etc.Although veterinary clinic according to circumstances replaces or unites the use medicine, because extensive use even the abuse of antibacterials, Resistant strain is more and more.Develop rapidly, propagate extensive, strength increase such as Drug Resistance of E. coli, fastbacteria develops into multidrug resistant by single drug resistance.20 century 70s are four anti-, five anti-bacterial strains are in the majority, and the eighties is five anti-, six anti-, seven anti-bacterial strains account for the overwhelming majority, and the nineties seven, anti-above bacterial strain ratio was near 90%.Because the bacterial resistance sexual development is rapid, the drug resistance strength increase causes medication effect to descend, so that disease is difficult to control, bacterial disease has become the main infectious disease in chicken farm now.For the fowl bacterial disease, still mainly use at present antibiotic or chemosynthesis antibacterials to treat, but antibacterial easily produces drug resistance to chemicals, and the chemicals toxic and side effects is larger, often only cure the symptoms, not the disease, the integral body of disease is prevented and treated bring unfavorable factor.Simultaneously, the use of chemicals also affects the safety of animal food, and harm humans is healthy.
Chinese herbal medicine belongs to pure natural substance, contains multiple biological effective components, has antibiotic, antiinflammatory, is difficult for producing the characteristics such as bacterial drug resistance, low toxicity, noresidue or low-residual, has medicine and nutrition dual-use function concurrently, not only takes stopgap measures but also effect a permanent cure.Therefore, Chinese herbal medicine instead of chemical medicine is prevented and treated the fowl bacterial disease and have larger economic benefit and environment protection significance.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, the Chinese medicine composition of the treatment fowl bacterial disease of a kind of safety, environmental protection, good effect, no drug residue and drug resistance is provided.
Another object of the present invention provides the preparation method of this treatment fowl bacterial disease Chinese medicine composition.
The invention provides a kind of Chinese medicine composition for the treatment of the fowl bacterial disease, contain active component, described active component is made by Herba Houttuyniae, Herba Portulacae, Herba Plantaginis, Radix Platycodonis, Herba Taraxaci, Fructus Trichosanthis, Fructus Rosae Laevigatae and Mahonia fortunei (Lindl.) Fedde.。
Wherein, Herba Houttuyniae 10-30 part, Herba Portulacae 10-30 part, Herba Plantaginis 5-25 part, Radix Platycodonis 5-25 part, Herba Taraxaci 5-25 part, Fructus Trichosanthis 5-25 part, Fructus Rosae Laevigatae 3-20 part, Mahonia fortunei (Lindl.) Fedde 3-20 part.
Further, Herba Houttuyniae 15-25 part, Herba Portulacae 15-25 part, Herba Plantaginis 10-20 part, Radix Platycodonis 10-20 part, Herba Taraxaci 10-20 part, Fructus Trichosanthis 10-20 part, Fructus Rosae Laevigatae 5-15 part, Mahonia fortunei (Lindl.) Fedde 5-15 part.
Further, 20 parts of Herba Houttuyniae, 20 parts of Herba Portulacaes, 15 parts of Herba Plantaginiss, 15 parts of Radix Platycodoniss, 15 parts of Herba Taraxacis, 15 parts of Fructus Trichosanthis, 10 parts of Fructus Rosae Laevigatae, 10 parts of Mahonia fortunei (Lindl.) Fedde.
Wherein, the dosage form of described Chinese medicine composition can be: pre-mixing agent, powder, powder, tablet, granule, oral liquid or injection.
The present invention also provides the preparation method of this treatment fowl bacterial disease Chinese medicine composition, comprises the steps:
(1) takes by weighing by weight ratio each medicine material;
(2) will claim each medicine material maybe will claim after pulverizing, sieving each medicine material through water or alcohol extraction, concentrated after, add again adjuvant or complementary composition that pharmacy can be used, be prepared from.
Wherein, the Chinese powder medicine of the treatment fowl bacterial disease that is made by described preparation method, its diameter of aspirin particle is below 50 microns.
The present invention also provides the Chinese medicine composition of described treatment fowl bacterial disease aspect treatment fowl bacterial disease medicament or in the application aspect anti-fowl bacterial disease feedstuff.
Each drug component in the Chinese medicine of the present invention and consumption thereof be to control principle according to the dialectical opinion of Chinese veterinarian's prescription, gets by repeatedly practising in a large number.Chinese medicine of the present invention has heat-clearing and toxic substances removing, the function of eliminating pathogenic heat from blood to cure dysentery, be prepared into preparation pharmaceutically commonly used after, cure mainly the fowl bacterial disease.Chinese medicine of the present invention also can add in the feedstuff, is prepared into the feedstuff of anti-fowl bacterial disease.
Advantage and the beneficial effect of medicine of the present invention are:
1) medicine performance Chinese medicine organic conception of the present invention and dialectical executing are administered opinion, good effect, instant effect, treating both the principal and secondary aspects of a disease can be used for preventing and treating the diseases such as yellow and white dysentery of piglet, Pullorum Disease, avian Escherichia coli disease, chicken staphylococcosis, infectious laryngotracheitis of chicken, Riemerellosis Anatipestifer disease;
2) Chinese medicine of the present invention adopts the modern pharmaceutical technology to be prepared, and uses modern means of science and technology that Effective Component of Chinese Medicine is carried out qualitative and quantitative detection, and constant product quality, controlled has the stronger market competitiveness;
3) medicine of the present invention is pure Chinese medicinal preparation, the drug residue that toxic and side effects is little, can not produce harm humans health, is difficult for producing drug resistance, free from environmental pollution;
4) medicine of the present invention can be absorbed and bring into play due drug effect in animal body fast, can adopt the modes such as mixed drink, mixed feeding to concentrate administration simultaneously, is beneficial to mass prevention and mass treatment;
5) medicine material wide material sources of the present invention, production technology is simple, and is easy to use, with low cost, saved widely medication expense.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Embodiment 1 medicine preparation of the present invention and use
1) take by weighing the raw material that contains following weight:
30 parts of Herba Houttuyniae, 30 parts of Herba Portulacaes, 25 parts of Herba Plantaginiss, 25 parts of Radix Platycodoniss, 25 parts of Herba Taraxacis, 25 parts of Fructus Trichosanthis, 20 parts of Fructus Rosae Laevigatae, 20 parts of Mahonia fortunei (Lindl.) Fedde
2) with claim in the step 1) each weight crude drug pulverize, sieve after, fully be mixed with into powder.
3) drug use method of the present invention: bacterial disease, mixed feeding: poultry, fowl, every 1kg feedstuff adds Chinese medicine 5-10g of the present invention, is used in conjunction 5-7 day.
Embodiment 2 medicine preparation of the present invention and uses
1) take by weighing the raw material that contains following weight:
10 parts of Herba Houttuyniae, 10 parts of Herba Portulacaes, 5 parts of Herba Plantaginiss, 5 parts of Radix Platycodoniss, 5 parts of Herba Taraxacis, 5 parts of Fructus Trichosanthis, 3 parts of Fructus Rosae Laevigatae, 3 parts of Mahonia fortunei (Lindl.) Fedde
2) with claim in the step 1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours first after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue is used water extraction 2 times again, extracts 2.5 hours for the first time, extracts 1.5 hours for the second time, filters, and merging filtrate also is condensed into the thick paste shape; Merge extractum, add at last appropriate amount of starch and dextrin (or other adjuvant), mix homogeneously is made soft material, granulates, and oven dry namely is prepared into granule (every 1g is equivalent to crude drug in whole 1g).
3) drug use method of the present invention: bacterial disease, mixed drink: poultry, fowl, every 1L water adds medicine 2-5g of the present invention, freely drinks, and is used in conjunction 5-7 day.
Embodiment 3 medicine preparation of the present invention and uses
1) take by weighing the raw material that contains following weight:
25 parts of Herba Houttuyniae, 25 parts of Herba Portulacaes, 20 parts of Herba Plantaginiss, 20 parts of Radix Platycodoniss, 20 parts of Herba Taraxacis, 20 parts of Fructus Trichosanthis, 15 parts of Fructus Rosae Laevigatae, 15 parts of Mahonia fortunei (Lindl.) Fedde
2) with claim in the step 1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours first after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue is used water extraction 2 times again, extracts 2.5 hours for the first time, extracts 1.5 hours for the second time, filters, and merging filtrate also is condensed into the thick paste shape; Merge extractum, add at last appropriate amount of starch and dextrin (or other adjuvant), mix homogeneously,, oven dry is pulverized, and namely is prepared into powder (every 1g is equivalent to crude drug in whole 1g).
3) drug use method of the present invention: bacterial disease, mixed feeding: poultry, fowl, every 1kg feedstuff adds medicine 5-10g of the present invention, is used in conjunction 5-7 day.
Embodiment 4 medicine preparation of the present invention and uses
1) take by weighing the raw material that contains following weight:
15 parts of Herba Houttuyniae, 15 parts of Herba Portulacaes, 10 parts of Herba Plantaginiss, 10 parts of Radix Platycodoniss, 10 parts of Herba Taraxacis, 10 parts of Fructus Trichosanthis, 5 parts of Fructus Rosae Laevigatae, 5 parts of Mahonia fortunei (Lindl.) Fedde
2) with claim in the step 1) each weight proportion crude drug pulverize after, after water soaks 1-2 hour with medical material, then decoct to boiling with high heat, used again slow fire boiling 30 minutes, filter, filtering residue adds water with slow fire boiling twice, each 1 hour.Merging filtrate is concentrated into 160 milliliters with filtrate, and adding ethanol ethanol content to the filtrate is 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 0.5g, and filtration, embedding, sterilization namely are prepared into oral liquid.
3) drug use method of the present invention: bacterial disease, mixed drink: poultry, fowl, every 1L water adds medicine 5-10ml of the present invention, freely drinks, and is used in conjunction 7.
Embodiment 5 medicine preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
20 parts of Herba Houttuyniae, 20 parts of Herba Portulacaes, 15 parts of Herba Plantaginiss, 15 parts of Radix Platycodoniss, 15 parts of Herba Taraxacis, 15 parts of Fructus Trichosanthis, 10 parts of Fructus Rosae Laevigatae, 10 parts of Mahonia fortunei (Lindl.) Fedde.
(2) with claim in the step (1) each weight proportion crude drug pulverize after, after water soaks 1-2 hour with medical material, then decoct to boiling with high heat, used again slow fire boiling 30 minutes, filter, filtering residue was with slow fire boiling twice, each 1 hour.Merging filtrate is concentrated into 120 milliliters with filtrate, and adding ethanol ethanol content to the filtrate is 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 1g, and cold preservation, filtration, fine straining, embedding, sterilization namely are prepared into injection.
(3) drug use method of the present invention: bacterial disease, intramuscular injection, each every 1kg body weight, sheep, pig 0.1-0.2ml/kg, rabbit, fowl 0.2ml 2 times on the one, are used in conjunction 5-7 day.Embodiment 6 medicine preparation of the present invention and uses
1) take by weighing the raw material that contains following weight:
30 parts of Herba Houttuyniae, 30 parts of Herba Portulacaes, 20 parts of Herba Plantaginiss, 20 parts of Radix Platycodoniss, 20 parts of Herba Taraxacis, 15 parts of Fructus Trichosanthis, 15 parts of Fructus Rosae Laevigatae, 10 parts of Mahonia fortunei (Lindl.) Fedde.
2) with claim in the step 1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours first after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into extractum; Filtering residue is used water extraction 2 times again, extracts 2.5 hours for the first time, extracts 1.5 hours for the second time, filter, merging filtrate also is condensed into extractum, adds at last appropriate amount of starch, magnesium stearate, granulation, tabletting, the every every 1g of 0.2g(is equivalent to crude drug in whole 2g), namely be prepared into tablet.
3) drug use method of the present invention: bacterial disease, rabbit, fowl 1-2 sheet are used in conjunction 5-7 day.
For showing medicine of the present invention to the prevention effect of fowl bacterial disease, medicine of the present invention is carried out the clinical observation on the therapeutic effect test, below further set forth the beneficial effect of medicine of the present invention by test example.
Test example 1
In May, 2012, Macheng City, Hubei Province newly buys on the pig farm 120 of piglets, and body weight is 15kg approximately, raises after 5 days, and white, the faint yellow or canescence thickness of part piglet milk ejection has the special stench symptoms such as pasty state feces, suffers from pig spirit and still can.According to epidemiology, clinical symptoms diagnosis, be diagnosed as piglet pujos blancos.Adopt embodiment 5 preparations medicine of the present invention, drug administration by injection, every 3.0ml, continuous use 5 days, drug withdrawal was paid a return visit afterwards on the 4th, and the raiser reflects that suffering from pig has stopped diarrhoea, and appetite, mental restoration are normal.
Test example 2
In November, 2011, new 600 plumages, 14 Japanese instar chicklings of introducing of Rongchang County, Chongqing chicken house, diarrhoea appears in the part chicken, arranges thin white paste sample feces, and perianal tomentum fecal pollution seals anus after drying up, and affects defecation.Blind or the arthritis of some generations, limping, sick chickling is many because of dyspnea and the heart failure symptom of waiting indefinitely.According to epidemiology, clinical symptoms, cut open inspection and change and laboratory diagnosis, be diagnosed as white diarrhea disease.Selecting wherein, 200 chickling of serious symptom are divided into 8 groups for examination.
Test grouping and administration: test is divided into 8 groups, and test 1 group and adopt embodiment 1 preparation, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 10g of the present invention; Test 2 groups and adopt embodiment 2 preparations, the administration of mixed drink, every 1L water adds Chinese medicine 5g of the present invention, freely drinks; Test 3 groups and adopt embodiment 3 preparations, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 10g of the present invention; Test 4 groups and adopt embodiment 4 preparations, the administration of mixed drink, every 1L water adds Chinese medicine 10ml of the present invention; Test 5 groups and adopt embodiment 5 preparations, intramuscular injection, every plumage 0.05ml; Test 6 groups and adopt embodiment 6 preparations, 1 on every plumage; Test 7 groups and adopt the loose powder of the herbal medicine Radix Pulsatillae, the mixed feeding administration, the per kilogram feedstuff adds the loose 10g of the Radix Pulsatillae; The not administration of blank group; Each test group is used in conjunction 7.Continue after the off-test to observe 2, statistical results see Table 2.
Table 2 medicine of the present invention is added up the Pullorum Disease curative effect
Result of the test shows: medicine of the present invention and the Radix Pulsatillae are loose to have good prevention effect to Pullorum Disease; Between each test group of medicine of the present invention, to test 5 groups of curative effects as best, test 3 groups and the test 4 groups take second place; It is loose that curative effect of medication of the present invention will significantly be better than the Radix Pulsatillae.
Test example 3
In July, 2012, chest and the subcutaneous generation edema of thigh appear in the chicken of Inner Mongol raiser's chicken house, and outward appearance is aubergine or atropurpureus, fluctuation is arranged, the part sheds feathers, and wing, chest, back subcutaneous has the serosity transudate, the skin edema, fester, the symptom such as stench.According to epidemiology, clinical symptoms, cut open inspection and change and laboratory diagnosis, be diagnosed as chicken staphylococcosis.Select 240 of the sick chickens that wherein state of an illness is more serious, be divided into 4 test group: test 1 group and adopt embodiment 2 preparations, the administration of mixed drink, every 1L water adds Chinese medicine 5g of the present invention; Test 2 groups and adopt embodiment 3 preparations, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 10g of the present invention; Test 3 groups and adopt the loose mixed feeding administrations of the white dragon of herbal medicines, the per kilogram feedstuff Jia Bailong 10g that falls apart; The blank group is not added any medicine; Each test group is used in conjunction 7.Continue after the off-test to observe 4, statistical results see Table 3.
Table 3 Chinese medicine of the present invention is to the curative effect statistics of chicken staphylococcosis
Result of the test shows: compare with the blank group, drug test group of the present invention and white dragon fall apart chicken staphylococcosis are had good prevention effect, and it is loose that curative effect of medication of the present invention significantly is better than Bai Long.
Test example 4
In November, 2011, the duck in age in Liu Panshui duck field, Guizhou 6-8 week is sudden death without any manifest symptom, and main clinic symptoms is somnolence, necking down, and beak supports ground, and bipod is weak, is reluctant to walk about, and is slow in action ataxia, loss of appetite or anorexia.The eye serosity or mucus secretions are arranged, often make two near the eyes the feather adhesion come off, also flow out serosity or mucus secretions in the nostril.Feces is thin, is green or yellow green, part duckling abdominal distension, and the symptom of nervous disorder appears in agonal stage, as shakes the head, nods or carry on the back neck, and two limbs stretch and are the opisthotonus state, and tarsal joint swelling appears in some cases, walks lamely, and can not lie prostrate.Be diagnosed as Riemerellosis Anatipestifer disease according to epidemiology, clinical symptoms.The duck isolated rearing that is in a bad way, adopt embodiment 6 preparations medicine of the present invention to treat 1 on every plumage to 109 ducks of isolated rearing; All the other ducks are only adopted embodiment 1 preparation medicine of the present invention, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 10g of the present invention.Through using continuously medicine of the present invention to pay a return visit after 7 days, except 11 serious sick duck death, all the other 98 sick ducks are almost recovered, and disease does not appear in all the other groups.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
1. a Chinese medicine composition for the treatment of the fowl bacterial disease contains active component, and described active component is made by Herba Houttuyniae, Herba Portulacae, Herba Plantaginis, Radix Platycodonis, Herba Taraxaci, Fructus Trichosanthis, Fructus Rosae Laevigatae and Mahonia fortunei (Lindl.) Fedde.
2. the Chinese medicine composition for the treatment of fowl bacterial disease according to claim 1, it is characterized in that Herba Houttuyniae 10-30 part, Herba Portulacae 10-30 part, Herba Plantaginis 5-25 part, Radix Platycodonis 5-25 part, Herba Taraxaci 5-25 part, Fructus Trichosanthis 5-25 part, Fructus Rosae Laevigatae 3-20 part, Mahonia fortunei (Lindl.) Fedde 3-20 part.
3. the Chinese medicine composition for the treatment of fowl bacterial disease according to claim 2, it is characterized in that Herba Houttuyniae 15-25 part, Herba Portulacae 15-25 part, Herba Plantaginis 10-20 part, Radix Platycodonis 10-20 part, Herba Taraxaci 10-20 part, Fructus Trichosanthis 10-20 part, Fructus Rosae Laevigatae 5-15 part, Mahonia fortunei (Lindl.) Fedde 5-15 part.
4. the Chinese medicine composition for the treatment of fowl bacterial disease according to claim 3 is characterized in that, 20 parts of Herba Houttuyniae, 20 parts of Herba Portulacaes, 15 parts of Herba Plantaginiss, 15 parts of Radix Platycodoniss, 15 parts of Herba Taraxacis, 15 parts of Fructus Trichosanthis, 10 parts of Fructus Rosae Laevigatae, 10 parts of Mahonia fortunei (Lindl.) Fedde.
5. the Chinese medicine composition of each described treatment fowl bacterial disease according to claim 1-4, it is pre-mixing agent, powder, powder, tablet, granule, oral liquid or injection.
6. the preparation method of the Chinese medicine composition of each described treatment fowl bacterial disease of claim 1-5 comprises the steps:
1) takes by weighing by weight ratio each medicine material;
2) will claim each medicine material maybe will claim after pulverizing, sieving each medicine material through water or alcohol extraction, concentrated after, add again adjuvant or complementary composition that pharmacy can be used, be prepared from.
7. the Chinese medicine composition composition powders made of preparation method according to claim 6 is characterized in that, its diameter of aspirin particle is below 50 microns.
8. the Chinese medicine composition of each described treatment fowl bacterial disease of claim 1-5 is in the application aspect treatment fowl bacterial disease medicament.
9. the Chinese medicine composition of each described treatment fowl bacterial disease of claim 1-5 is in the application aspect anti-fowl bacterial disease feedstuff.
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| CN104645033A (en) * | 2013-11-21 | 2015-05-27 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition for treating staphylococcosis in chickens and preparation method thereof |
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| CN105053646A (en) * | 2015-08-07 | 2015-11-18 | 杨珊洪 | Mandarin fish disease resistance improving feed additive |
| CN105168516A (en) * | 2015-10-13 | 2015-12-23 | 钟云仙 | Compound Chinese herbal medicinal powder for treating chronic respiratory disease of livestock and poultry and preparation method of compound Chinese herbal medicinal powder |
| CN109170224A (en) * | 2018-11-28 | 2019-01-11 | 江西中成人药业有限公司 | A kind of natural compounding type Chinese medicine fodder of substitute antibiotics |
| CN113940966A (en) * | 2021-11-09 | 2022-01-18 | 江西普正制药股份有限公司 | Callicarpa nudiflora composition for treating escherichia coli infection and preparation method and application thereof |
| CN113940966B (en) * | 2021-11-09 | 2023-07-07 | 江西普正制药股份有限公司 | Callicarpa nudiflora composition for treating escherichia coli infection and preparation method and application thereof |
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Effective date of registration: 20220706 Address after: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee after: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee after: Shaoshan Da Bei Nong Animal Pharmaceutical Co., Ltd. Address before: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee before: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee before: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd. Patentee before: Shaoshan Dabeinong Animal Medicine Co.,Ltd. |