CN101317879B - Medicament for treating eperythrozoon diseases of cattle, sheep and pig - Google Patents
Medicament for treating eperythrozoon diseases of cattle, sheep and pig Download PDFInfo
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- CN101317879B CN101317879B CN2008101326309A CN200810132630A CN101317879B CN 101317879 B CN101317879 B CN 101317879B CN 2008101326309 A CN2008101326309 A CN 2008101326309A CN 200810132630 A CN200810132630 A CN 200810132630A CN 101317879 B CN101317879 B CN 101317879B
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Abstract
The present invention discloses a medicine used for curing eperythrozoonosis of cattle, sheep and pig, which is pure Chinese traditional medicine preparation made from a great variety of traditional Chinese medicinal materials in definite weight proportions. The present invention has good curatorial synergistic effect and strong killing effect on the eperythrozoonosis of cattle, sheep and pig. The medicine can rapidly enhance body resistance and detoxification capacity of cattle, sheep and pig. The medicine can prevent secondary infection and other diseases, promote rehabilitation, improve anemia, remove heat from the blood and reduce fever, promote functional recovery of erythrocyte and thrombocyte and guarantee the curative effect.
Description
Technical field
The present invention relates to the veterinary and use medicine, a kind of specifically veterinary drug for the treatment of cattle, sheep, eperythrozoon suis disease.
Background technology
Along with the raising of living standards of the people, the animal husbandry of China is in government, and scientific research department and large-scale plant make joint efforts, and development circumstances is good down.Yet the eperythrozoonosis of cattle, sheep, pig has the situation that is tending towards serious in recent years, and therefore suffer heavy losses on a lot of cattle farms, Yang Chang, pig farm.Eperythrozoonosis parasitizes erythrocyte surface, and blood plasma, tissue fluid and brain chi chung cause that a kind of people, animal of symptoms such as anemia, jaundice, heating, fowl are total to ill.People's infection positive rate can reach 86%, and cattle, sheep infection rate reach 85%, and the infection rate of the pig in each stage reaches 80-90%.Present be widely current world many countries and area of primary disease.Also there has been the history in more than 30 year in China.This disease is very harmful to aquaculture, and acute case can cause serious clinical symptoms and death, and chronic case then can cause production capacity to descend breast, the minimizing of meat product amount etc.And inapparent infection rate that should disease is high, and the people, animal of inapparent infection not only break out when stress easily, and easily concurrent with other disease, even death, brings difficulty to diagnosis and treatment.
At present, treating this disease, often to use chemical drugss such as " sulfamonomethoxine ", " Benny you ", " oxytetracycline ", " doxycycline " be main, but the development cost costliness of chemical drugs, toxic and side effects is big, mutagenesis toxicity is in various degree arranged more, milk, meat, egg are residual big, and external government tends to as breast, meat, the egg product of excuse refusal import China.In addition, do not meet the product of export standard in a large number,, caused potential harm China consumer is healthy then by domestic market oneself digestion.
Summary of the invention
Purpose of the present invention just provides the pure Chinese medicinal preparation medicine of a kind of good effect, short treating period, consumption is few, residual less, cost is low treatment cattle, sheep, swine eperythrozoonosis.Is the epoch at center now with back to nature with life sciences, and research directions that some developed countries propose from synthetics turn to the medicine of seeking treatment in natural Chinese medicinal herb.So we take active action, again through clinical trial for many years, develop prescription with pure Chinese medicine extraction effective ingredient, repeatedly small quantities of demonstration test shows according to available data: evident in efficacy, treating both the principal and secondary aspects of a disease, safely, have no side effect noresidue, do not influence milk matter, meat does not have this melancholy of commodity inspection, favored by numerous raisers, helps improving the physique of the nation people.
The present invention be directed to cattle, sheep eperythrozoon suis disease, choose and have good synergistic medicine and carry out compatibility preparation.
Herba Artemisiae Annuae contains artesunate, Artemether, arteether, dihydroarteannuin, wherein artesunate has the powerful ability of killing to Eperythrozoon.Folium Isatidis heat-clearing and toxic substances removing, the clear pestilence of removing heat from blood; The Chinese angelica blood supplementing nourshing blood and promoting blood circulation, Folium Isatidis, when being classified as ministerial drug, assistant makes the Radix Astragali improve machine immunity, and the auxilliary the monarch and his subjects of common association wipe out focus.It is remarkable that Herba Artemisiae Annuae and Folium Isatidis, Radix Angelicae Sinensis, the Radix Astragali have the synergistic function effect.
The present invention is made by the following weight proportion raw material: Herba Artemisiae Annuae 5-15 part, Folium Isatidis 4-8 part, Radix Angelicae Sinensis 3-7 part, Radix Astragali 2-6 part.
The specific embodiment
The present invention can be prepared into powder, oral liquid, granule, injection, wherein with injection treatment directly, rapidly, should deposit.
With treatment cattle of the present invention, sheep, eperythrozoon suis injection, trade name " attached red excellent " test: according to this disease clinical symptoms, cooperate blood tabletting and the painted method of blood push jack, 60 of the positive milch cows of milch cow Eperythrozoon of selection natural infection case are divided three groups (20 every group).The I group is doxycycline hydrochloride injection treatment group, consumption 15-20mg/ kg body weight, every day 1 time, intramuscular injection logotype 5 days; II group Benny's that 6mg/ kg body weight, once a day, intramuscular injection logotype 5 days; III group intramuscular injection " attached red excellent " 5mg/ kg body weight, once a day, logotype 3 days.Carry out clinical observation to all milch cows of participating in test every day, and be 10 days observing time, and the blood smear microscopy is done in blood sampling, the record result.Duration of test, test is unified feeding and management with positive milch cow.
Criterion: clinical symptom disappearance, diet recover normal, and the normal person that urinates is for curing.Simultaneously to whether there being Eperythrozoon to detect in the blood.
Result of the test
The treatment Niu Xiaoguo of three kinds of medicines sees the following form:
| Medicine | Clinical cure (head) | Clinical cure rate (%) | Peripheral blood detects the routine number of Eperythrozoon | Peripheral blood detects the ratio (%) of Eperythrozoon | The state of an illness is rate (%) repeatedly |
| Sulfamonomethoxine sodium | 14 | 70 | 8 | 40 | 25 |
| Benny's that | 15 | 75 | 6 | 30 | 10 |
| Attached red excellent | 19 | 95 | 0 | 0 | 0 |
Clinical trial certificate, " attached red excellent " to the effect of milch cow Eperythrozoon significantly better than Benny you and sulfamonomethoxine sodium injection.State of an illness phenomenon does not repeatedly all take place in 19 cow heads during the medication, and your group of Benny and sulfamonomethoxine sodium have 2 and the 5 cow head generation state of an illness repeatedly respectively.
As can be seen from the above table, attached red excellent injection for treating effect is best, only has 1 example to cause death because of serious anemia, and all the other are all cured, and detect less than Eperythrozoon in the blood.Your clinical cure rate of Benny is 70%, and the case that treatment back peripheral blood detects Eperythrozoon is 30%.The clinical cure rate of sulfamonomethoxine sodium is 65%, and the case that treatment back peripheral blood detects Eperythrozoon is 40%.
Three kinds of Drug therapy eperythrozoon suis effects see the following form.
| Medicine | An experiment number | Clinical cure (head) | Clinical cure rate (%) | Peripheral blood detects the routine number of Eperythrozoon | Peripheral blood detects the ratio (%) of Eperythrozoon | The state of an illness is rate (%) repeatedly |
| Doxycycline hydrochloride | 30 | 21 | 70 | 12 | 40 | 20 |
| Benny's that | 30 | 23 | 76 | 9 | 30 | 10 |
| Attached red excellent | 30 | 29 | 96 | 0 | 0 | 0 |
Experiment effect obviously is better than other medicines, can substitute other similar drugs, and toxic and side effects is few. and milk, meat do not have the melancholy of commodity inspection, and cost is low, helps improving the overall quality of the population, and favourable animal husbandry develops in a healthy way.
Innovative point:
1 according to motherland's Chinese medicine theory, and in conjunction with knowledge such as modern Chinese medicine, reasonable compatibility cooperation potentiation is set up prescription and determined most preferred dosage form.
2 according to infective pathogen, directly selects medicine, from the active anti-Eperythrozoon material of extracted form natural plant, with strong points.
3 according to clinical symptoms, and from the dynamic change of molecular biology horizontal adjustment body related immune competent cell and cytokine, careful to the basic mechanism of this treatment of diseases, effect is remarkable.
4, by research to pharmacokinetics, selected the dosage form that the most suitable body absorbs, be optimal treatment approach and Therapeutic Method at type.
5, this product is a pure Chinese medicinal preparation, does not contain any antibiotic, chemical hormone etc., and noresidue has no side effect, and is safe, is the environmental type preparation.
Claims (1)
1. medicine for the treatment of cattle, sheep, eperythrozoon suis disease, the component that it is characterized in that its crude drug is that Herba Artemisiae Annuae, Folium Isatidis, Radix Angelicae Sinensis, the Radix Astragali and its described composition weight proportioning are Herba Artemisiae Annuae 5-15 part, Folium Isatidis 4-8 part, Radix Angelicae Sinensis 3-7 part, Radix Astragali 2-6 part.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101326309A CN101317879B (en) | 2008-07-08 | 2008-07-08 | Medicament for treating eperythrozoon diseases of cattle, sheep and pig |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101326309A CN101317879B (en) | 2008-07-08 | 2008-07-08 | Medicament for treating eperythrozoon diseases of cattle, sheep and pig |
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| CN101317879A CN101317879A (en) | 2008-12-10 |
| CN101317879B true CN101317879B (en) | 2011-04-13 |
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| CN2008101326309A Expired - Fee Related CN101317879B (en) | 2008-07-08 | 2008-07-08 | Medicament for treating eperythrozoon diseases of cattle, sheep and pig |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104666558A (en) * | 2013-11-26 | 2015-06-03 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for preventing and treating swine eperythrozoonosis and preparation method of traditional Chinese medicinal composition |
| CN104784167B (en) * | 2015-04-02 | 2017-08-15 | 河南黑马动物药业有限公司 | A kind of medicine for treating animal eperythrozoonosis and preparation method thereof |
| RU2639771C1 (en) * | 2016-10-04 | 2017-12-22 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московская государственная академия ветеринарной медицины и биотехнологии - МВА имени К.И. Скрябина" (ФГБОУ ВО МГАВМиБ - МВА имени К.И. Скрябина) | Method for prevention and treatment of iron deficiency anemia of calves under conditions of arid zones |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100371461C (en) * | 2006-02-27 | 2008-02-27 | 浙江大学 | Swine red cell body PCR detecting method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100371461C (en) * | 2006-02-27 | 2008-02-27 | 浙江大学 | Swine red cell body PCR detecting method |
Non-Patent Citations (2)
| Title |
|---|
| 刘德福.奶牛附红细胞体病并发弓形虫病的诊断报告.《畜牧与兽医》.2004,第36卷(第5期),34-35. * |
| 程秀荀.应用中药青蒿治疗附红细胞体病.《兽药疫苗》.2007,(第11期),90. * |
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